IL-17A在银屑病关节炎中的作用:机制、临床意义和治疗策略的进展

IF 3.9 3区 医学 Q2 IMMUNOLOGY
Francesco Caso, Anella Saviano, Noemi Marigliano, Gian Marco Casillo, Michele Peluso, Miriam Ciccone, Simona Serao Creazzola, Teresa D'Agostino, Adel Abo Mansour, Marco Tasso, Mario Cascone, Matteo Megna, Asif Jilani Iqbal, Raffaele Scarpa, Luisa Costa, Francesco Maione
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引用次数: 0

摘要

简介:银屑病关节炎(PsA)是一种涉及皮肤和滑膜-骨膜腔室的免疫炎性疾病。对IL-17生物学功能的了解彻底改变了对PsA发病机制的理解,从而改变了其治疗方法。涵盖领域:在这篇综述文章中,我们概述了关于IL-17A在PsA中的生物学功能的主要证据,并总结了PsA和银屑病的随机对照试验(rct)的数据,这些试验批准了secukinumab、ixekizumab、bimekizumab、brodalumab和新兴的IL-17抑制剂。专家意见:生物疾病改善抗风湿药物(bDMARDs), secukinumab和ixekizumab靶向白细胞介素- 17a (IL-17A),以及同时中和IL-17A和IL-17F的bimekizumab,已经证明在治疗PsA的周围和轴向关节表现,以及改善皮肤受损伤,鼻炎和指炎方面都有疗效。Brodalumab抑制IL-17受体A (IL-17RA),是治疗牛皮癣的有效策略。继续研究il -17在PsA发病机制中的作用对于提高我们对该疾病的理解和制定更有效的治疗策略至关重要。生物疗法的进一步研究和进展将完善IL-17抑制策略,可能改善PsA患者和其他免疫介导疾病的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
IL-17A in psoriatic arthritis: mechanistic insights, clinical implications, and advances in therapeutic strategies.

Introduction: Psoriatic arthritis (PsA) is an immune-inflammatory disease involving skin and synovial-entheseal compartments. The understanding of IL-17 biological function has revolutionized the understanding of PsA pathogenesis and, consequently, its therapeutic approach.

Areas covered: In this review article, we have outlined the primary evidence regarding the biological functions of IL-17A in PsA, and summarized data from randomized controlled trials (RCTs) on PsA and psoriasis approved secukinumab, ixekizumab, bimekizumab, brodalumab, and emerging IL-17 inhibitors.

Expert opinion: The biologic disease-modifying antirheumatic drugs (bDMARDs), secukinumab, and ixekizumab target interleukin-17A (IL-17A), and bimekizumab, which simultaneously neutralizes IL-17A and IL-17F, have demonstrated efficacy in treating both peripheral and axial articular manifestations of PsA, as well in improving skin involvement, enthesitis and dactylitis. Brodalumab, which inhibits the IL-17 receptor A (IL-17RA), represent an efficacious strategy for psoriasis.Continued research into the role of IL-17s in PsA pathogenesis is crucial for improving our understanding of the disease and developing more effective therapeutic strategies. Further research and advancements in biologic therapies will refine IL-17 inhibitory strategies, potentially improving outcomes for PsA patients, and other immune-mediated diseases.

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来源期刊
CiteScore
7.60
自引率
2.30%
发文量
221
审稿时长
6-12 weeks
期刊介绍: Expert Review of Clinical Immunology (ISSN 1744-666X) provides expert analysis and commentary regarding the performance of new therapeutic and diagnostic modalities in clinical immunology. Members of the International Editorial Advisory Panel of Expert Review of Clinical Immunology are the forefront of their area of expertise. This panel works with our dedicated editorial team to identify the most important and topical review themes and the corresponding expert(s) most appropriate to provide commentary and analysis. All articles are subject to rigorous peer-review, and the finished reviews provide an essential contribution to decision-making in clinical immunology. Articles focus on the following key areas: • Therapeutic overviews of specific immunologic disorders highlighting optimal therapy and prospects for new medicines • Performance and benefits of newly approved therapeutic agents • New diagnostic approaches • Screening and patient stratification • Pharmacoeconomic studies • New therapeutic indications for existing therapies • Adverse effects, occurrence and reduction • Prospects for medicines in late-stage trials approaching regulatory approval • Novel treatment strategies • Epidemiological studies • Commentary and comparison of treatment guidelines Topics include infection and immunity, inflammation, host defense mechanisms, congenital and acquired immunodeficiencies, anaphylaxis and allergy, systemic immune diseases, organ-specific inflammatory diseases, transplantation immunology, endocrinology and diabetes, cancer immunology, neuroimmunology and hematological diseases.
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