Eurosurveillance最新文献

{"title":"Adenovirus type 7d outbreak associated with severe clinical presentation, Finland, February to June 2024.","authors":"Santtu Heinonen, Elina Erra, Richard Lundell, Aino Nyqvist, Pilvi Hepo-Oja, Laura Mannonen, Hanna Jarva, Raisa Loginov, Erika Lindh, Leif Lakoma, Petri Kangaspunta, Ilkka Laaksi, Marjaana Pitkäpaasi, Carita Savolainen-Kopra, Simo Nikkari, Hanna Nohynek, Otto Helve, Eeva Ruotsalainen, Niina Ikonen","doi":"10.2807/1560-7917.ES.2025.30.7.2500061","DOIUrl":"10.2807/1560-7917.ES.2025.30.7.2500061","url":null,"abstract":"<p><p>We report an adenovirus outbreak with unusually severe clinical presentation, particularly in military conscripts and their close contacts. During 1 February-30 June 2024, 129 patients with adenovirus infection were hospitalised, 30 were admitted to ICU, 10 required ECMO treatment and six died. Cases consisted of 75 conscripts (58.1%) and 54 civilians (41.9%). Most samples were type 7 (97/108; 89.8%); all 24 sequenced samples were subtype 7d. During 1 August-30 November 2024, 274 additional hospitalised cases were identified from registries.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 7","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 vaccine effectiveness in the paediatric population aged 5-17 years: a multicentre cohort study using electronic health registries in six European countries, 2021 to 2022.","authors":"Patrícia Soares, Ausenda Machado, Nathalie Nicolay, Susana Monge, Chiara Sacco, Christian Holm Hansen, Hinta Meijerink, Iván Martínez-Baz, Susanne Schmitz, James Humphreys, Massimo Fabiani, Aitziber Echeverria, Ala'a AlKerwi, Anthony Nardone, Alberto Mateo-Urdiales, Jesús Castilla, Esther Kissling, Baltazar Nunes","doi":"10.2807/1560-7917.ES.2025.30.8.2400450","DOIUrl":"10.2807/1560-7917.ES.2025.30.8.2400450","url":null,"abstract":"<p><p>BackgroundDuring the first year of the COVID-19 pandemic, vaccination programmes targeted children and adolescents to prevent severe outcomes of SARS-CoV-2 infection.AimTo estimate COVID-19 vaccine effectiveness (VE) against hospitalisation due to COVID-19 in the paediatric population, among those with and without previously documented SARS-CoV-2 infection.MethodsWe established a fixed cohort followed for 12 months in Denmark, Norway, Italy, Luxembourg, Navarre (Spain) and Portugal using routine electronic health registries. The study commenced with paediatric COVID-19 vaccination campaign at each site between June 2021 and January 2022. The outcome was hospitalisation with a laboratory-confirmed SARS-CoV-2 infection or COVID-19 as the main diagnosis. Using Cox proportional hazard models, VE was estimated as 1 minus the confounder-adjusted hazard ratio of COVID-19 hospitalisation between vaccinated and unvaccinated. A random-effects meta-analysis was used to pool VE estimates.ResultsWe included 4,144,667 5-11-year-olds and 3,861,841 12-17-year-olds. In 12-17-year-olds without previous infection, overall VE was 69% (95% CI: 40 to 84). VE declined with time since vaccination from 77% ≤ 3 months to 48% 180-365 days after immunisation. VE was 94% (95% CI: 90 to 96), 56% (95% CI: 3 to 80) and 41% (95% CI: -14 to 69) in the Delta, Omicron BA.1/BA.2 and BA.4/BA.5 periods, respectively. In 12-17-year-olds with previous infection, one dose VE was 80% (95% CI: 18 to 95). VE estimates were similar for 5-11-year-olds but with lower precision.ConclusionVaccines recommended for 5-17-year-olds provided protection against COVID-19 hospitalisation, regardless of a previously documented infection of SARS-CoV-2, with high levels of protection in the first 3 months of the vaccination.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 8","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early vaccine effectiveness estimates against medically attended laboratory-confirmed influenza based on influenza surveillance, Beijing, China, 2024/25 season.","authors":"Ying Sun, Weixian Shi, Daitao Zhang, Chunna Ma, Zhaomin Feng, Jiaojiao Zhang, Dan Wu, Li Zhang, Jia Li, Wei Duan, Yingying Wang, Jiaxin Ma, Lu Zhang, Xiaodi Hu, Peng Yang, Quanyi Wang","doi":"10.2807/1560-7917.ES.2025.30.7.2500084","DOIUrl":"10.2807/1560-7917.ES.2025.30.7.2500084","url":null,"abstract":"<p><p>We estimated early influenza vaccine effectiveness (VE) for the 2024/25 season in outpatients, in Beijing using a test-negative design. A(H1N1)pdm09 dominated (99.3%), all sequenced strains (n = 38) clustered in clade 6B.1A.5a.2a, and 37 of 38 antigenically similar to the vaccine strain. VE against any influenza virus infection was 48.5% (95% CI: 34.8-59.5) and 48.7% (95% CI: 35.1-59.7) against A(H1N1)pdm09. Vaccination in the current or previous season against any influenza showed a VE of 52.5% to 54.9%, compared to no vaccination in both seasons.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 7","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interim 2024/25 influenza vaccine effectiveness: eight European studies, September 2024 to January 2025.","authors":"Angela Mc Rose, Héloïse Lucaccioni, Kimberly Marsh, Freja Kirsebom, Heather Whitaker, Hanne-Dorthe Emborg, Amanda Bolt Botnen, Mark G O'Doherty, Francisco Pozo, Safraj Shahul Hameed, Nick Andrews, Mark Hamilton, Ramona Trebbien, Karina Lauenborg Møller, Diogo Fp Marques, Siobhan Murphy, Ross McQueenie, Jamie Lopez-Bernal, Simon Cottrell, Magda Bucholc, Esther Kissling","doi":"10.2807/1560-7917.ES.2025.30.7.2500102","DOIUrl":"10.2807/1560-7917.ES.2025.30.7.2500102","url":null,"abstract":"<p><p>The 2024/25 influenza season in Europe is currently characterised by co-circulation of influenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses, with influenza A(H1N1)pdm09 predominating. Interim vaccine effectiveness (VE) estimates from eight European studies (17 countries) indicate an all-age influenza A VE of 32-53% in primary care and 33-56% in hospital settings, with some signals of lower VE by subtype and higher VE against influenza B (≥ 58% across settings). Where feasible, influenza vaccination should be encouraged and other prevention measures strengthened.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 7","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inferring transmission risk of respiratory viral infection from the viral load kinetics of SARS-CoV-2, England, 2020 to 2021 and influenza A virus, Hong Kong, 2008 to 2012.","authors":"Jakob Jonnerby, Joe Fenn, Seran Hakki, Jie Zhou, Kieran J Madon, Aleksandra Koycheva, Sean Nevin, Rhia Kundu, Michael A Crone, Timesh D Pillay, Shazaad Ahmad, Nieves Derqui, Emily Conibear, Robert Varro, Constanta Luca, Paul S Freemont, Graham P Taylor, Maria Zambon, Wendy S Barclay, Jake Dunning, Neil M Ferguson, Benjamin J Cowling, Ajit Lalvani","doi":"10.2807/1560-7917.ES.2025.30.6.2400234","DOIUrl":"10.2807/1560-7917.ES.2025.30.6.2400234","url":null,"abstract":"<p><p>BackgroundInfectiousness of respiratory viral infections is quantified as plaque forming units (PFU), requiring resource-intensive viral culture that is not routinely performed. We hypothesised that RNA viral load (VL) decline time (e-folding time) in people might serve as an alternative marker of infectiousness.AimThis study's objective was to evaluate the association of RNA<b> </b>VL decline time with RNA and PFU<b> </b>VL area under the curve (AUC) and transmission risk for SARS-CoV-2 and influenza A virus.MethodsIn SARS-CoV-2 and influenza A virus community cohorts, viral RNA was quantified by reverse transcription quantitative PCR in serial upper respiratory tract (URT)-samples collected within households after an initial household-member tested positive for one virus. We evaluated correlations between RNA<b> </b>VL decline time and RNA and PFU-VL AUC. Associations between VL decline time and transmission risk in index-contact pairs were assessed.ResultsIn SARS-CoV-2 cases, we observed positive correlations between RNA<b> </b>VL decline time and RNA and PFU<b> </b>VL AUC with posterior probabilities 1 and 0.96 respectively. In influenza A cases a positive correlation between RNA<b> </b>VL decline time and RNA<b> </b>VL AUC was observed, with posterior probability of 0.87. Index case VL decline times one standard deviation above the cohort-mean showed a relative increase in secondary attack rates of 39% (95%<b> </b>credible interval (CrI):<b> </b>-6.9<b> </b>to<b> </b>95%) for SARS-CoV-2 and 25% (95% CrI:<b> </b>-11 to 71%) for influenza A virus.ConclusionWe identify VL decline time as a potential marker of infectiousness and transmission risk for SARS-CoV-2 and influenza A virus. Early ascertainment of VL kinetics as part of surveillance of new viruses or variants could inform public health decision making.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 6","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular screening to track ceftriaxone-resistant FC428-like <i>Neisseria gonorrhoeae</i> strains' dissemination in four provinces of China, 2019 to 2021.","authors":"Leshan Xiu, Liqin Wang, Yamei Li, Lihua Hu, Jia Huang, Gang Yong, Youwei Wang, Wenling Cao, Yang Yang, Weiming Gu, Junping Peng","doi":"10.2807/1560-7917.ES.2025.30.6.2400166","DOIUrl":"10.2807/1560-7917.ES.2025.30.6.2400166","url":null,"abstract":"<p><p>BackgroundThe global dissemination of ceftriaxone-resistant <i>Neisseria gonorrhoeae</i> FC428-like strains poses a public health concern. To assess and follow their spread, establishing effective antimicrobial resistance (AMR) surveillance systems is essential.AimThis study aimed to track ceftriaxone-resistant FC428-like strains in parts of China, using a molecular screening tool.MethodsSamples were collected from Sichuan, Zhejiang, Shanghai, and Guangdong provinces between 2019 and 2021. We employed a rapid molecular tool - the high-resolution melting analysis-based FC428 (HRM-FC428) assay, to screen for FC428-like strains. All FC428-like strains detected were further characterised by genotyping and PCR-sequencing.ResultsOf 1,042 tested samples, 44 harboured the <i>penA</i>-60.001 allele linked to ceftriaxone resistance, revealing a 4.2% prevalence of FC428-like strains. The HRM-FC428 assay additionally uncovered six strains with mosaic <i>penA</i>-195.001 or <i>penA</i>-232.001 alleles, both bearing the A311V mutation, a ceftriaxone resistance marker. During the study, the prevalence of FC428-like strains among overall samples appeared to increase, with rates of 2.8% (11/395) in 2019, 4.2% (16/378) in 2020, and 6.3% (17/269) in 2021. Some strains' sequence types (ST)s were identified across provinces (e.g. ST1903, ST1600) and most strains (24/44) were ST1903, an ST also reported in other regions/countries, suggesting local evolution and global transmission.ConclusionOur work underscores the value of culture-independent antimicrobial resistance monitoring and validates the use of molecular diagnostic tools, like the HRM-FC428 assay for this purpose. This study offers insights into the complex landscape of ceftriaxone-resistant <i>N. gonorrhoeae</i>, emphasising the importance of continued surveillance and global collaboration to mitigate this growing public health threat.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 6","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detections of rare enterovirus C105 linked to an emerging novel clade, Spain, 2019 to 2024.","authors":"Maria Dolores Fernandez-Garcia, Juan Camacho, Francisco Diez-Fuertes, Estrella Ruiz de Pedro, Nerea García-Ibañez, Ana Navascués, Carla Berengua, Pedro Antequera-Rodriguez, Montserrat Ruiz-García, Maria Teresa Pastor-Fajardo, María Cabrerizo","doi":"10.2807/1560-7917.ES.2025.30.6.2500073","DOIUrl":"10.2807/1560-7917.ES.2025.30.6.2500073","url":null,"abstract":"<p><p>Enterovirus (EV)-C105 is a rare genotype not previously detected in Spain. Between 2019 and 2024, we detected EV-C105 in respiratory samples of five patients, through routine EV surveillance. Three cases had respiratory illness and two were hospitalised for neurological illness. Four of the five sequenced strains belonged to an emerging clade (C1), defined by four novel nonsynonymous mutations in key antigenic epitopes. We recommend reinforced clinical awareness and EV genomic surveillance, including respiratory samples, even when symptoms are neurological.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 6","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outbreak of listeriosis associated with consumption of deli meats in a hospital, Germany, February to March 2023.","authors":"Lena Feige, Nicole Walter, Ahmad Fawzy, Tilman Schultze, Melanie Hassel, Manfred Vogt, Philipp Zanger, Anja Schoeps","doi":"10.2807/1560-7917.ES.2025.30.7.2400316","DOIUrl":"10.2807/1560-7917.ES.2025.30.7.2400316","url":null,"abstract":"<p><p><i>Listeria monocytogenes</i> can cause severe illness in individuals with weakened immune systems. In March 2023, <i>L. monocytogenes</i> was isolated from blood (n = 2) or pleural fluid (n = 1) of three febrile patients receiving synthetic glucocorticoids in a tertiary hospital in Germany. Food supply records suggested sliced parboiled sausage as the likely source, and <i>L. monocytogenes</i> was isolated from four samples of sealed packaged sliced sausages and ham from one manufacturer. The patient and food isolates clustered within 0-4 allelic differences. Counts of <i>L. monocytogenes</i> in all four food samples were < 100 colony-forming units (CFU)/g, a threshold in the European Union legislation for ready-to-eat products with specific conditions. Our findings, aligned with previous evidence, highlight that persons with weakened immune systems should not be exposed to <i>L. monocytogenes</i> in food. We advocate for a clear communication of deli meats as high-risk foods, so individuals with weakened immune systems can adjust their diet to reduce their risk for invasive listeriosis. We recommend an update of dietary and hygiene guidelines for care settings and private homes where food is prepared, handled and stored for persons with weakened immune systems.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 7","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate public health surveillance response to cyclone Chido, Mayotte, 14 December 2024.","authors":"Marion Soler, Annabelle Lapostolle, Quiterie Mano, Maxime Ransay-Colle, Julie Durand, Louis Collet, Tanguy Cholin, Karima Madi, Laurent Filleul, Yvan Souares, Patrick Rolland, Hassani Youssouf","doi":"10.2807/1560-7917.ES.2025.30.6.2500060","DOIUrl":"10.2807/1560-7917.ES.2025.30.6.2500060","url":null,"abstract":"<p><p>On 14 December 2024, Cyclone Chido caused extensive damage to infrastructures in Mayotte, including water, electricity and communication networks. Health surveillance systems were no longer functional. Santé publique France provided health risk analyses to support local control measures. Malnutrition and dehydration, follow-up care, pregnancy and post-partum complications, mental health, gastrointestinal diseases, bacterial wound superinfections and bronchiolitis were the main risk identified. The preliminary ad hoc surveillance systems confirmed our analyses. We also present lessons learnt 1 month after the event.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 6","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143412832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Eurosurveillance</i> reviewers in 2024.","authors":"","doi":"10.2807/1560-7917.ES.2025.30.1.2501097","DOIUrl":"10.2807/1560-7917.ES.2025.30.1.2501097","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 1","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11719807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}