EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.13.250403e
{"title":"Erratum for Euro Surveill. 2025;30(5).","authors":"","doi":"10.2807/1560-7917.ES.2025.30.13.250403e","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.250403e","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.14.2500234
Christina Frank, Claire Jenkins, Jana-Marie Weis, Anja Brilmayer, Anja Schoeps, Susann Dupke, Hendrik Wilking, Parisha Katwa, Satheesh Nair, Clare Barker, Derren Ready, Gauri Godbole, Susan Hopkins, Hilary Kirkbride
{"title":"Cholera due to exposure in Europe associated with consumption of holy water from Ethiopia, January to February 2025.","authors":"Christina Frank, Claire Jenkins, Jana-Marie Weis, Anja Brilmayer, Anja Schoeps, Susann Dupke, Hendrik Wilking, Parisha Katwa, Satheesh Nair, Clare Barker, Derren Ready, Gauri Godbole, Susan Hopkins, Hilary Kirkbride","doi":"10.2807/1560-7917.ES.2025.30.14.2500234","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.14.2500234","url":null,"abstract":"<p><p>In February 2025, public health agencies in Germany and the United Kingdom (UK) reported four cases of domestically acquired cholera caused by consumption of holy water imported from Ethiopia, and a further three cases in travellers to Ethiopia. Multidrug-resistant <i>Vibrio cholerae</i> O1, linked to recent outbreaks in Eastern and Middle Africa, was detected in clinical specimens and the holy water. In cholera-endemic regions, visitors should drink potable water and should not bring bottled water back from their travels.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 14","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.16.2400684
David N Springer, Christian Borsodi, Jeremy V Camp, Monika Redlberger-Fritz, Heidemarie Holzmann, Michael Kundi, Judith H Aberle, Karin Stiasny, Lukas Weseslindtner
{"title":"Seroprevalence against measles, Austria, stratified by birth years 1922 to 2024.","authors":"David N Springer, Christian Borsodi, Jeremy V Camp, Monika Redlberger-Fritz, Heidemarie Holzmann, Michael Kundi, Judith H Aberle, Karin Stiasny, Lukas Weseslindtner","doi":"10.2807/1560-7917.ES.2025.30.16.2400684","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.16.2400684","url":null,"abstract":"<p><p>BackgroundVaccination programmes initiated in the early 1970s reduced the incidence of measles in Austria, which resulted in the interruption of endemic measles virus (MeV) circulation and the achievement of elimination status in 2018. However, large outbreaks occurred in 2023 and 2024.AimBy assessing MeV-specific IgG antibody levels, we analysed if immunity recently declined due to the COVID-19 pandemic, vaccine-induced immunity waned over long term or immunity gaps already pre-existed in the population.MethodsWe determined anti-MeV antibody levels in a retrospective dataset of 56,360 diagnostic samples (from 50,754 individuals) collected 2010-2024 and correlated antibody cutoffs to titres from a live-virus neutralisation test.ResultsIndividuals born before 1970 (n = 15,007) had antibody levels > 3,000 IU/L, persisting into higher age, and < 2% (n = 300) of them were seronegative. In contrast, individuals born after 1990 (n = 12,778) displayed seronegativity rates of 13-20% and lower median antibody concentrations in seropositive individuals (449-773 IU/L). In these individuals, antibody levels decreased noticeably between the ages of 2 and 10 years but remained stable between those aged 10 and 30 years. There was no significant difference in seronegativity rates at the age of 12-24 months in children born 2016-2019 and 2020-2022 (the years of the COVID-19 pandemic).ConclusionIn Austria, there are significant immunity gaps in individuals born after 1970, which pre-existed before the COVID-19 pandemic. Thus, young and middle-aged populations not immune against measles should be vaccinated to counteract a further decline of immunity at the population level and prevent outbreaks whenever MeV is imported.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 16","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.15.2400515
Emmanouil Alexandros Fotakis, Berta Grau-Pujol, David Kelly, Pedro Pinto Leite, João Vieira Martins, Maria João Alves, Marco Di Luca, Giulietta Venturi, Federica Ferraro, Florian Franke, Clément Pietin, Clémentine Calba, Tanja Charles, Flavia Riccardo, Paula Vasconcelos, Lauriane Ramalli
{"title":"Description and comparison of national surveillance systems and response measures for <i>Aedes</i>-borne diseases in France, Italy and Portugal: a benchmarking study, 2023.","authors":"Emmanouil Alexandros Fotakis, Berta Grau-Pujol, David Kelly, Pedro Pinto Leite, João Vieira Martins, Maria João Alves, Marco Di Luca, Giulietta Venturi, Federica Ferraro, Florian Franke, Clément Pietin, Clémentine Calba, Tanja Charles, Flavia Riccardo, Paula Vasconcelos, Lauriane Ramalli","doi":"10.2807/1560-7917.ES.2025.30.15.2400515","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.15.2400515","url":null,"abstract":"<p><p>BackgroundRegions of southern Europe are increasingly colonised by <i>Aedes albopictus,</i> with incidence of autochthonous dengue cases rising in recent years.AimWe describe and compare <i>Aedes</i>-borne disease (dengue, chikungunya and Zika) incidence from 2017 to 2023, and the surveillance systems and response measures operating in France, Italy and Portugal in 2023, to improve surveillance, prevention, preparedness and response in Europe.MethodsWe performed a benchmarking analysis to systematically capture the systems used in each country. We collected data from key-informant interviews, national guidelines, reports and scientific literature using a standardised questionnaire adapted from the European Centre for Disease Prevention and Control framework.ResultsAll three countries have an integrated surveillance system for <i>Aedes</i>-borne diseases and share similarities in surveillance type, geographic coverage and case definitions. Differences entail mainly event-based and active surveillance activities. Geographic coverage of vector surveillance is national in France and Portugal but regional in Italy. In response to autochthonous transmission, all countries implement/foresee active case-finding and blood safety protocols, while France and Italy strongly rely on vector control. Upon vector detection in non-colonised areas, the three countries implement ad hoc entomological surveillance and vector control.ConclusionsSurveillance systems and response measures in France, Italy and Portugal are broadly similar, with variations reflecting differences in healthcare system organisation (centralised in Portugal and France, regionalised in Italy), <i>Ae. albopictus</i> distribution and local transmission of <i>Aedes-</i>borne diseases. Risk-based surveillance, considering the national and cross-border epidemiological and entomological situations, can strengthen preparedness and early warning for <i>Aedes</i>-borne diseases in Europe.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 15","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007401/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.15.2400487
Michalis Koureas, Asimina Nasika, Athanasios G Lianos, Alexandros Vontas, Maria A Kyritsi, Ioanna Voulgaridi, Alexia Matziri, Zacharoula Bogogiannidou, Fani Kalala, Varvara A Mouchtouri, Matthaios Speletas, Christos Hadjichristodoulou
{"title":"Seroprevalence of West Nile virus, Greece, 2020.","authors":"Michalis Koureas, Asimina Nasika, Athanasios G Lianos, Alexandros Vontas, Maria A Kyritsi, Ioanna Voulgaridi, Alexia Matziri, Zacharoula Bogogiannidou, Fani Kalala, Varvara A Mouchtouri, Matthaios Speletas, Christos Hadjichristodoulou","doi":"10.2807/1560-7917.ES.2025.30.15.2400487","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.15.2400487","url":null,"abstract":"<p><p>BackgroundWest Nile virus (WNV) is a growing public health concern in Europe. Greece is one of the most affected countries in Europe, with the highest annual incidences.AimWe aimed at assessing IgG antibodies to WNV in the Greek population and compared the results with a nationwide survey conducted in the period 2012-2013.MethodsIn a geographically stratified sampling, 4,416 serum samples were collected and analysed for WNV-specific IgG antibodies using ELISA. Samples positive for WNV IgG were further tested with a WNV serum neutralisation test to detect false positives.ResultsThe weighted seroprevalence, adjusted for age, sex and region, was 2.83% (95% confidence interval (CI): 2.32-3.44) in the 4,416 samples tested, significantly higher than in the 2012-2013 survey (1.55%; 95% CI: 1.17-2.04). The seropositivity increased with age with the highest seroprevalence in persons aged ≥ 80 years (6.04%; 95% CI: 3.28-10.88). No significant differences in seropositivity were observed between sexes or regions. We estimated that 312 (95% CI: 256-379) persons had a WNV infection per a case of West Nile neuroinvasive disease (WNND). A certain degree of discordance was observed between areas with increased seroprevalence and those with an increased incidence of WNND.ConclusionOur study reveals a wider geographical spread of WNV infections in Greece compared with previous investigations. The nearly twofold increase in seroprevalence highlights the need for ongoing monitoring and preventive measures to mitigate the impact of WNV on public health in Greece.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 15","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.16.2400673
Emma J Heymer, Stephen A Clark, Helen Campbell, Sonia Ribeiro, Lloyd Walsh, Jay Lucidarme, Xilian Bai, Tom Irving, Anna Hoad, Jaime Morgan, Ray Borrow, Shamez N Ladhani
{"title":"Use of 4CMenB vaccine in the control of an outbreak of serogroup B invasive meningococcal disease in an elderly care home, England, November 2023.","authors":"Emma J Heymer, Stephen A Clark, Helen Campbell, Sonia Ribeiro, Lloyd Walsh, Jay Lucidarme, Xilian Bai, Tom Irving, Anna Hoad, Jaime Morgan, Ray Borrow, Shamez N Ladhani","doi":"10.2807/1560-7917.ES.2025.30.16.2400673","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.16.2400673","url":null,"abstract":"<p><p>In November 2023, a cluster of two invasive meningococcal disease (IMD) cases caused by serogroup B <i>Neisseria meningitidis</i> (MenB) occurred in elderly residents (≥ 70 years) of a dementia care home in England. An epidemiological investigation was conducted and public health actions, including infection control measures and antibiotic chemoprophylaxis, were implemented to prevent further cases. Nasopharyngeal swabbing before chemoprophylaxis identified three meningococcal carriers, including two carrying the outbreak strain, highlighting the importance of immediate antibiotic prophylaxis in such settings. Microbiological investigations showed that the outbreak strain belonged to the sequence type (ST)-9316 complex, potentially covered by the 4CMenB vaccine. Although 4CMenB is licensed for children and adults, there are no safety or reactogenicity data on use in older adults (≥ 65 years). Given the severity of IMD, residents (64-95 years) and staff (18-72 years) were offered 4CMenB for longer-term protection, with daily diary cards to monitor side effects. In total, 30 residents and 35 of 47 staff received the first dose, with completed diary cards for 26 residents and 32 staff. Twenty-six residents and 28 staff received the second dose, and all completed diary cards. Elderly residents reported fewer and less severe side effects after each dose than younger staff.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 16","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.14.2400399
Rebecca L Guy, Katie L Hopkins, Emma L Budd, Kate Wilson, Holly Fountain, Danièle Meunier, Rachel Pike, Sarah M Gerver, Roshina Gnanadurai, Colin S Brown, Susan Hopkins, Berit Muller-Pebody
{"title":"The importance of monitoring a new antibiotic: ceftazidime/avibactam usage and resistance experience from England, 2016 to 2020.","authors":"Rebecca L Guy, Katie L Hopkins, Emma L Budd, Kate Wilson, Holly Fountain, Danièle Meunier, Rachel Pike, Sarah M Gerver, Roshina Gnanadurai, Colin S Brown, Susan Hopkins, Berit Muller-Pebody","doi":"10.2807/1560-7917.ES.2025.30.14.2400399","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.14.2400399","url":null,"abstract":"<p><p>BackgroundCeftazidime/avibactam, launched in the United Kingdom (UK) in March 2017, is an antibiotic against multidrug-resistant Gram-negative pathogens. It was selected for the government's subscription model pilot, for incentivising new antibiotic development, which began in December 2020.AimAhead of the pilot, we assessed ceftazidime/avibactam testing, resistance (2016-2020) and usage (2017-2020) levels in England, as baselines for future surveillance.MethodsFrom routine surveillance samples, we retrieved reported ceftazidime/avibactam resistance categorisation. From reference laboratory samples, we reviewed minimum inhibitory concentration (MICs) and molecular data. Among surveillance samples, per cent resistance was estimated. Referred samples' MICs, by carbapenemase gene presence, were investigated. Ceftazidime/avibactam hospital use was measured in defined daily doses (DDDs).ResultsOverall, 6.3% (4,200/66,914; 95% confidence interval (95%CI): 6.1-6.4%) of surveillance-reported ceftazidime/avibactam-tested Gram-negative bacteria were resistant. Percentage resistance per bacterial species varied over time, somewhat stabilising as testing was established, with between April 2019 and March 2020, 1.3% <i>Escherichia coli</i> (288/22,736; 95%CI: 1.1-1.4%), 12.6% <i>Pseudomonas aeruginosa</i> (690/5,495; 95%CI: 11.7-13.5%) and 6.1% of <i>Klebsiella pneumoniae</i> (314/5,179; 95%CI: 5.4-6.7%) being resistant. For 8,437 referred Enterobacterales, MIC determination found 11.5% (968/8,437; 95%CI: 10.8-12.2%) resistant. Among resistant isolates, 89.3% (864/968; 95%CI: 87.1-91.1%) had metallo-β-lactamase (MBL) genes. Of 908 MBL-negative isolates, producing ≥ 1 non-metallo-carbapenemase(s), 2.1% (19/908; 95%CI: 1.3-3.2%) were resistant. Since March 2017, 69.5% (105/151) of English National Health Service Trusts used ceftazidime/avibactam. Monthly usage progressed from 21 to 744 DDDs in March 2020.ConclusionFor appropriate treatment, carbapenemase gene detection and variant identification in ceftazidime/avibactam surveillance matters. Detecting emerging resistant pathogens and preventing spread within healthcare settings requires vigilance.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 14","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-04-01DOI: 10.2807/1560-7917.ES.2025.30.16.2500025
Thomas Rowland, Robin Gopal, Monika Patel, Cristina Celma, Colin Nj Campbell, Nicholas Machin, Scott Taylor, Shauni-Lea Graham, Kathryn Harris, Spiro Pereira, Vanessa Saliba, Maria Zambon
{"title":"Community surveillance after detection of poliovirus in the environment in London, United Kingdom, October 2022 to April 2023.","authors":"Thomas Rowland, Robin Gopal, Monika Patel, Cristina Celma, Colin Nj Campbell, Nicholas Machin, Scott Taylor, Shauni-Lea Graham, Kathryn Harris, Spiro Pereira, Vanessa Saliba, Maria Zambon","doi":"10.2807/1560-7917.ES.2025.30.16.2500025","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.16.2500025","url":null,"abstract":"<p><p>BackgroundVaccine-derived polioviruses (VDPVs) continue to circulate internationally, causing sporadic cases and outbreaks of paralytic polio in countries certified as polio-free. In 2022, sustained detection of type 2 VDPVs was reported in environmental surveillance samples collected from London. Genetic mutations indicative of loss of attenuation of virulence were observed, consistent with community transmission events over several months.AimWe aimed to determine the extent of geographical spread of transmission in an area of environmental poliovirus detection.MethodsWe implemented an opportunistic, cross-sectional survey in areas where environmental surveillance indicated sustained VDPV transmission between October 2022 and April 2023. Residual stool samples taken from children < 16 years presenting to primary or secondary healthcare were examined for enteroviruses, including poliovirus. Methods for poliovirus detection recommended by the World Health Organization, including virus isolation in cell culture, PCR and molecular characterisation, were applied to residual stool material on a daily basis with real-time clinical reporting.ResultsWe examined 1,251 stool samples from 1,051 children presenting to healthcare with illness over a 6-month period. A range of enteroviruses from groups A, B and C were found, but no poliovirus was detected. Documented polio vaccination coverage was high, between 95% and 98% in under 5-year-olds.ConclusionPoliovirus was not widespread in the area of environmental poliovirus isolation. Opportunistic poliovirus testing of residual stool samples taken from children seeking healthcare was feasible and can be implemented rapidly in areas where poliovirus circulation is suspected, although untargeted sampling may not adequately capture populations at highest risk.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 16","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143987530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EurosurveillancePub Date : 2025-03-01DOI: 10.2807/1560-7917.ES.2025.30.9.2400312
Andrea Mazzella, Zahin Amin-Chowdhury, Amelia Andrews, Andre Charlett, Colin S Brown, Russell Hope, Dimple Chudasama
{"title":"Health inequalities in incidence of bacteraemias: a national surveillance and data linkage study, England, 2018 to 2022.","authors":"Andrea Mazzella, Zahin Amin-Chowdhury, Amelia Andrews, Andre Charlett, Colin S Brown, Russell Hope, Dimple Chudasama","doi":"10.2807/1560-7917.ES.2025.30.9.2400312","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2400312","url":null,"abstract":"<p><p>BackgroundHealth inequalities exist globally, but limited data exist on this topic for bacteraemia.AimIn this study we investigated health inequalities surrounding bacteraemia in England, to identify high-risk population groups and areas of intervention.MethodsWe retrospectively analysed English surveillance data between 2018 and 2022 for <i>Escherichia coli</i>, <i>Klebsiella</i> species, <i>Pseudomonas aeruginosa</i>, and both meticillin-sensitive and resistant <i>Staphylococcus aureus</i> (MSSA, MRSA) bacteraemia. Crude incidence rates stratified by index of multiple deprivation and ethnic groups were calculated; age-adjusted rate ratios were estimated using negative binomial regression models.ResultsWe identified 342,787 bacteraemia cases. Across all pathogens, as the level of deprivation rose, so did the age-adjusted bacteraemia incidence rate ratio. Compared with residents of the 20% least deprived areas of England, residents of the 20% most deprived areas had a 2.68-fold increased bacteraemia rate for MRSA (95% CI: 2.29-3.13) and 1.95-fold for <i>E. coli</i> (95% CI: 1.84-2.05), and 15% higher odds of dying within 30 days of any bacteraemia (95% CI: 1.13-1.19). After age adjustment, the incidence of all bacteraemia was higher in the Asian and Black groups compared with the White group: for MRSA, 79% higher in the Asian (95% CI: 1.51-2.10) and 59% higher in the Black (95% CI: 1.29-1.95) groups. The exception was MSSA, whose incidence was highest in the White group.ConclusionDisproportionately higher age-adjusted incidence of bacteraemia occurred in deprived areas and ethnic minorities. These disparities are likely multifactorial, possibly including socioeconomic, cultural, and systemic risk factors and different burden of comorbidities. Better understanding these factors can enable targeted interventions.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}