Eurosurveillance最新文献

{"title":"Prioritisation of infectious diseases from a public health perspective: a multi-criteria decision analysis study, France, 2024.","authors":"Dominique Ploin, Mathilde Alexandre, Bruno Ventelou, Didier Che, Bruno Coignard, Nathalie Boulanger, Christophe Burucoa, François Caron, Pierre Gallian, Yves Hansmann, Christian Lienhardt, Philippe Minodier, Henri Partouche, Matthieu Revest, Nadia Saidani, Gilles Salvat, Nicolas Vignier, Sylvie Floreani, Sabine Henry, Bruno Pozzetto, Bruno Hoen","doi":"10.2807/1560-7917.ES.2024.29.50.2400074","DOIUrl":"10.2807/1560-7917.ES.2024.29.50.2400074","url":null,"abstract":"<p><p>BackgroundWithin the International Health Regulations framework, the French High Council for Public Health was mandated in 2022 by health authorities to establish a list of priority infectious diseases for public health, surveillance and research in mainland and overseas France.AimOur objective was to establish this list.MethodsA multi-criteria decision analysis was used, as recommended by the European Centre for Disease Prevention and Control. A list of 95 entities (infectious diseases or groups of these, including the World Health Organization (WHO)-labelled 'Disease X') was established by 17 infectious disease experts. Ten criteria were defined to score entities: incidence rate, case fatality rate, potential for emergence and spread, impact on the individual, on society, on socially vulnerable groups, on the healthcare system, and need for new preventive tools, new curative therapies, and surveillance. Each criterion was assigned a relative weight by 77 multidisciplinary experts. For each entity, 98 physicians from various specialties rated each criterion against the entity, using a four-class Likert-type scale; the ratings were converted into numeric values with a nonlinear scale and respectively weighted to calculate the entity score.ResultsFifteen entities were ranked as high-priorities, including Disease X and 14 known pathologies (e.g. haemorrhagic fevers, various respiratory viral infections, arboviral infections, multidrug-resistant bacterial infections, invasive meningococcal and pneumococcal diseases, prion diseases, rabies, and tuberculosis).ConclusionThe priority entities agreed with those of the WHO in 2023; almost all were currently covered by the French surveillance and alert system. Repeating this analysis periodically would keep the list updated.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 50","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons for difficulties in isolating the causative organism during food-borne outbreak investigations using STEC as a model pathogen: a systematic review, 2000 to 2019.","authors":"Christina Anthony, Karen Pearson, Rebecca Callaby, Lesley Allison, Claire Jenkins, Alison Smith-Palmer, Marianne James","doi":"10.2807/1560-7917.ES.2024.29.49.2400193","DOIUrl":"10.2807/1560-7917.ES.2024.29.49.2400193","url":null,"abstract":"<p><p>IntroductionFood-borne disease outbreak investigations use epidemiological, microbiological and food chain evidence to identify the implicated food and inform risk management actions.AimsWe used Shiga toxin-producing <i>Escherichia coli</i> (STEC) as a model pathogen to investigate the success of outbreak strain isolation from food or environmental samples during outbreak investigations, and examined the factors influencing the chance of isolation.MethodsWe searched for reports of food-borne STEC outbreak investigations worldwide in peer-reviewed and grey literature in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.ResultsWe found a total of 223 outbreaks suitable for inclusion. Food and/or environmental samples were available for testing in 137 investigations, and the outbreak strain was isolated in 94 (42%) of investigations. We found no significant effect of STEC serovar or size of outbreak on likelihood of successful outbreak strain isolation. Isolation success ranged across different implicated commodities from 86% for beef-related outbreaks to 50% for salads and leafy greens. In 20% of outbreaks with samples available for testing, an additional STEC strain was isolated alongside the outbreak strain and in 6.6%, only an alternative STEC strain was isolated. Risk management action was taken on epidemiological evidence alone in 21 incidents.ConclusionThe principal reasons why the outbreak strain was not isolated were lack of sample availability and methodological issues concerned with laboratory isolation. We recommend strategies that could improve the likelihood of isolation including the rapid collection of samples based on epidemiological intelligence.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 49","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccinating against the absent: Risks of the B/Yamagata strain in the live attenuated vaccine.","authors":"Parvaiz A Koul","doi":"10.2807/1560-7917.ES.2024.29.49.2400766","DOIUrl":"10.2807/1560-7917.ES.2024.29.49.2400766","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 49","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macrolide-resistant <i>Bordetella pertussis</i> strain identified during an ongoing epidemic, Finland, January to October 2024.","authors":"Milja Miettinen, Alex-Mikael Barkoff, Aino Nyqvist, Carita Savolainen-Kopra, Jenni Antikainen, Jussi Mertsola, Lauri Ivaska, Qiushui He","doi":"10.2807/1560-7917.ES.2024.29.49.2400765","DOIUrl":"10.2807/1560-7917.ES.2024.29.49.2400765","url":null,"abstract":"<p><p>Since April 2024, a pertussis epidemic has been ongoing in Finland with 2,215 notified cases by end October. Of them, 30.1% (n = 667) were aged 10-14 years. Of the 462 <i>Bordetella pertussis</i> isolates characterised, one was macrolide-resistant (minimum inhibitory concentration (MIC) of erythromycin, azithromycin and clarithromycin > 256 μg/mL). The resistant isolate was serotype FIM2, vaccine antigen pertactin-deficient and harboured <i>ptxP3</i> allele. The emergence of macrolide-resistant <i>B. pertussis</i> in Europe is worrisome and its rapid identification is important.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 49","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' correction for Euro Surveill. 2024;29(48).","authors":"","doi":"10.2807/1560-7917.ES.2024.29.49.241205c","DOIUrl":"10.2807/1560-7917.ES.2024.29.49.241205c","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 49","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence of OXA-48-producing ST-22 <i>Citrobacter freundii</i> in patients and the hospital environment, Paris, France, 2016 to 2022.","authors":"Sarah Jolivet, Jeanne Couturier, Killian Le Neindre, Muriel Ehmig, Laurent Dortet, Cécile Emeraud, Frédéric Barbut","doi":"10.2807/1560-7917.ES.2024.29.49.2400262","DOIUrl":"10.2807/1560-7917.ES.2024.29.49.2400262","url":null,"abstract":"<p><p>In 2016-2019, hospital A's haematology ward experienced an outbreak of OXA-48-producing ST-22 <i>Citrobacter freundii</i> strains, with toilets identified as source of transmission. Between 2020 and 2022, 28 strains of OXA-48-producing ST-22 <i>C. freundii</i> were isolated on other wards. This study aimed to determine whether all OXA-48-producing ST-22 <i>C. freundii</i> strains belonged to the same clone and to investigate the persistence of this clone using whole genome sequencing. OXA-48-producing ST-22 <i>C. freundii</i> strains collected from patients (n = 33) and from the hospital environment (n = 20) of seven wards were sequenced using Illumina technology and clonal relationships were determined using single nucleotide polymorphism (SNP). Phylogenetic analyses were performed on 53 strains from hospital A and on 240 epidemiologically unrelated carbapenem-resistant ST-22 <i>C. freundii</i> isolated from elsewhere in France. SNP analysis suggested long-lasting persistence of the same clone for more than 6 years. Phylogenetic analysis showed that 52 of 53 strains isolated in hospital A belonged to the same cluster and were different from the 240 epidemiologically unrelated <i>C. freundii</i> ST-22. Our data suggest that this clone can persist in hospital environments for years, representing a risk for hospital-acquired infections and outbreaks. Reservoir management is essential to prevent further transmission.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 49","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142785056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive <i>Streptococcus pneumoniae</i> infections are associated with different serotypes than invasive infections, Belgium, 2020 to 2023.","authors":"Ioannis Passaris, Stéphanie Depickère, Toon Braeye, Marina Mukovnikova, Alexandra Vodolazkaia, Chloé Abels, Lize Cuypers, Stefanie Desmet, Pieter-Jan Ceyssens","doi":"10.2807/1560-7917.ES.2024.29.45.2400108","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400108","url":null,"abstract":"<p><p>BackgroundDespite widely implemented pneumococcal vaccination programmes, <i>Streptococcus pneumoniae</i> remains a global risk for human health. <i>Streptococcus pneumoniae</i> can cause invasive (IPD) or non-invasive pneumococcal disease (NIPD). Surveillance is mainly focusing on IPD, assessing the full impact of pneumococcal vaccination programmes on pneumococcal disease is challenging.AimWe aimed to prospectively investigate serotype distribution and antimicrobial resistance (AMR) of <i>S. pneumoniae</i> isolates from patients with NIPD and compare with data on IPD isolates and with a 2007-2008 dataset on NIPD.MethodsBetween September 2020 and April 2023, we collected isolates and patient data from patients with NIPD from 23 clinical laboratories in Belgium. Capsular typing was performed by a validated Fourier-Transform Infrared spectroscopic method, and AMR was assessed with broth microdilution, using the European Committee on Antimicrobial Susceptibility Testing (EUCAST) clinical breakpoints.ResultsWe received <i>S. pneumoniae</i> isolates from 1,008 patients with lower respiratory tract infections (n = 760), otitis media (n = 190) and sinusitis (n = 58). Serotype 3 was the most prevalent serotype among the NIPD isolates. Serotypes not included in the 20-valent pneumococcal conjugate vaccine (PCV20) were significantly more common among the NIPD than among the IPD isolates. Antimicrobial resistance levels were significantly higher among the NIPD isolates (n = 539; 2020-2022) compared with the IPD isolates (n = 2,344; 2021-2022). Resistance to several β-lactam antimicrobials had increased significantly compared with 15 years before.ConclusionsThe NIPD isolates were strongly associated with non-vaccine serotypes and with increased AMR levels. This underlines the importance of continued NIPD surveillance for informed policy making on vaccination programmes.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Setting thresholds to determine COVID-19 activity levels using the mean standard deviation (MSD) method, England, 2022-2024.","authors":"Mary A Sinnathamby, Tania Bourouphael, Jacob Boateng, Magali Collonnaz, Catherine Quinot, Nurin Abdul Aziz, Suzanne Elgohari, Rebecca E Green, Gavin Dabrera, Jamie Lopez-Bernal, Alex Allen","doi":"10.2807/1560-7917.ES.2024.29.45.2400696","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400696","url":null,"abstract":"<p><p>We developed a new activity level setting threshold method, the mean standard deviation (MSD) method to quantify COVID-19 activity levels. This has been validated against the moving epidemic method (MEM), which has been used for influenza for many years, and we observed very similar results. The MSD method can prove to be a tool to use for respiratory viruses with limited historical data or seasonality to quantify activity levels when other respiratory viruses are also circulating.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Escherichia coli</i> from six European countries reveals differences in profile and distribution of critical antimicrobial resistance determinants within One Health compartments, 2013 to 2020.","authors":"Håkon P Kaspersen, Michael Sm Brouwer, Javier Nunez-Garcia, Ingrid Cárdenas-Rey, Manal AbuOun, Nicholas Duggett, Nicholas Ellaby, Jose Delgado-Blas, Jens A Hammerl, Maria Getino, Carlos Serna, Thierry Naas, Kees T Veldman, Alex Bossers, Marianne Sunde, Solveig S Mo, Silje B Jørgensen, Matthew Ellington, Bruno Gonzalez-Zorn, Roberto La Ragione, Philippe Glaser, Muna F Anjum","doi":"10.2807/1560-7917.ES.2024.29.47.2400295","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400295","url":null,"abstract":"<p><p>BackgroundAntimicrobial resistance (AMR) is a global threat. Monitoring using an integrated One Health approach is essential to detect changes in AMR occurrence.AimWe aimed to detect AMR genes in pathogenic and commensal <i>Escherichia coli</i> collected 2013-2020 within monitoring programmes and research from food animals, food (fresh retail raw meat) and humans in six European countries, to compare vertical and horizontal transmission.MethodsWe whole genome sequenced (WGS) 3,745 <i>E. coli</i> isolates<b>,</b> detected AMR genes using ResFinder and performed phylogenetic analysis to determine isolate relatedness and transmission. A BLASTn-based bioinformatic method compared draft IncI1 genomes to conserved plasmid references from Europe.ResultsResistance genes to medically important antimicrobials (MIA) such as extended-spectrum cephalosporins (ESC) were widespread but predicted resistance to MIAs authorised for human use (carbapenem, tigecycline) was detected only in two human and three cattle isolates. Phylogenetic analysis clustered <i>E. coli</i> according to phylogroups; commensal animal isolates showed greater diversity than those from human patients. Only 18 vertical animal-food and human-animal transmission events of <i>E. coli</i> clones were detected. However, IncI1 plasmids from different sources and/or countries carrying resistance to ESCs were conserved and widely distributed, although these variants were rarely detected in human pathogens.ConclusionUsing WGS we demonstrated AMR is driven vertically and horizontally. Human clinical isolates were more closely related, but their IncI1 plasmids were more diverse, while animal or food isolates were less similar with more conserved IncI1 plasmids. These differences likely arose from variations in selective pressure, influencing AMR evolution and transmission.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583308/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of <i>Escherichia coli</i> ST131 carrying carbapenemase genes, European Union/European Economic Area, August 2012 to May 2024.","authors":"Anke Kohlenberg, Olov Svartström, Petra Apfalter, Rainer Hartl, Pierre Bogaerts, Te-Din Huang, Katerina Chudejova, Lucia Malisova, Jessica Eisfeld, Mirco Sandfort, Anette M Hammerum, Louise Roer, Kati Räisänen, Laurent Dortet, Rémy A Bonnin, Ákos Tóth, Kinga Tóth, Christina Clarke, Martin Cormican, Algirdas Griškevičius, Kirstin Khonyongwa, Marie Meo, Baiba Niedre-Otomere, Reinis Vangravs, Antoni Pa Hendrickx, Daan W Notermans, Ørjan Samuelsen, Manuela Caniça, Vera Manageiro, Vilhelm Müller, Barbro Mäkitalo, Urška Kramar, Mateja Pirs, Daniel Palm, Dominique L Monnet, Erik Alm, Marius Linkevicius","doi":"10.2807/1560-7917.ES.2024.29.47.2400727","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400727","url":null,"abstract":"<p><p>Analysis of 594 isolates of <i>Escherichia coli</i> sequence type (ST)131 and its single locus variants carrying carbapenemase genes from 17 European Union/European Economic Area countries revealed acquisition of 18 carbapenemase variants, mainly in ST131 clades A and C. Most frequent were <i>bla</i> _OXA-244 (n = 230) and <i>bla</i> _OXA-48 (n = 224), detected in 14 and 12 countries, respectively. Isolates carrying <i>bla</i> _OXA-244 have increased rapidly since 2021. The increasing detection of carbapenemase genes in the <i>E. coli</i> high-risk lineage ST131 is a public health concern.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}