Eurosurveillance最新文献

{"title":"ESCAIDE 2025: call for abstracts.","authors":"","doi":"10.2807/1560-7917.ES.2025.30.15.250417m","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.15.250417m","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 15","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007404/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of an outbreak of novel hepatitis of unknown aetiology in children and adolescents, Ireland, 2021 to 2023.","authors":"Emer Liddy, Niamh Murphy, Jolita Mereckiene, Emer Fitzpatrick, Annemarie Broderick, Róisin Egan, Tiarnán Fallon Verbruggen, Julie-Anne Houlihan, Christine Campbell, Michael Carr, Gabriel Gonzalez, Jonathan Dean, Richard Hagan, Cillian De Gascun, Suzanne Cotter","doi":"10.2807/1560-7917.ES.2025.30.14.2400536","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.14.2400536","url":null,"abstract":"<p><p>An outbreak of severe acute hepatitis of unknown aetiology in children (HUAC) was reported by the United Kingdom (UK) in spring 2022. Within days, a corresponding increase was identified in Ireland. A multi-agency incident management team (IMT), led by the Health Protection Surveillance Centre (HPSC), established a national case definition, trawling questionnaire, testing protocol and communications plan. Between 1 October 2021 and 12 May 2023, 44 probable and three possible cases of HUAC were identified in Ireland with a median age of 3 years. Adeno-associated virus 2 (AAV2), detected in 18 of 31 probable cases, and SARS-CoV-2 antibodies in 22 of 37 of probable cases were the most common infectious agents, followed by human herpes virus 7 (18/33) and adenovirus (20/44). Immunological findings included the human leukocyte antigen (HLA) class II <i>HLA-DRB1*04:01</i> allele in 17 of 32 cases. Autoantibodies were found in 15 of 40 patients. Our findings corroborate those of the UK, which suggested a link between HUAC and AAV2 and another virus, in children predisposed due to presence of a particular HLA class II type. Close collaboration with the UK, the European Centre for Disease Prevention and Control (ECDC) and World Health Organization (WHO) was invaluable in the investigation.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 14","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying hotspots and risk factors for tick-borne encephalitis virus emergence at its range margins to guide interventions, Great Britain.","authors":"Richard Mj Hassall, Maya Holding, Jolyon M Medlock, Festus A Asaaga, Sophie O Vanwambeke, Roger Hewson, Bethan V Purse","doi":"10.2807/1560-7917.ES.2025.30.13.2400441","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2400441","url":null,"abstract":"<p><p>BackgroundTick-borne encephalitis virus (TBEV) is expanding its range in Europe, with increasing human cases reported. Since the first detection of TBEV in ticks in the United Kingdom in 2019, one possible, two probable and two confirmed autochthonous cases in humans have been reported.AimWe aimed to understand the environmental and ecological factors limiting TBEV foci at their range edge and predict suitable areas for TBEV establishment across Great Britain (GB) by modelling patterns of exposure to TBEV in deer.MethodsWe developed spatial risk models for TBEV by integrating data between 2018 and 2021 on antibodies against tick-borne flavivirus in fallow, muntjac, red and roe deer with data on potential risk factors, including climate, land use, forest connectivity and distributions of bank voles and yellow-necked mice. We overlayed modelled suitability for TBEV exposure across GB with estimations on number of visitors to predict areas of high human exposure risk.ResultsModels for fallow, muntjac and roe deer performed well in independent validation (Boyce index > 0.92). Probable exposure to TBEV was more likely to occur in sites with a greater percentage cover of coniferous woodland, with multiple deer species, higher winter temperatures and rates of spring warming.ConclusionThe resulting TBEV suitability maps can be used by public health bodies in GB to tailor surveillance and identify probable high-risk areas for human exposure to guide awareness raising and vaccination policy. Combining animal surveillance and iterative spatial risk modelling can enhance preparedness in areas of tick-borne disease emergence.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Germany, 2023.","authors":"Anna Bludau, Alexander Jack, Nicole Fischer, Johannes Dreesman, Christian Drosten, Richard Egelkamp, Lutz Ehlkes, Fabian Feil, Adam Grundhoff, Hajo Grundmann, Pascal Kreuzer, Masyar Monazahian, Inga Overesch, Daniel Schmitt, Markus Tröger, Alexandra von Reiswitz, Jonas Weber, Alexander Dilthey, Claudia Hornberg, Sandra Reuter, Simone Scheithauer","doi":"10.2807/1560-7917.ES.2025.30.13.2400508","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2400508","url":null,"abstract":"<p><p>BackgroundIntegrated genomic surveillance (IGS), i.e. the integrated analysis of pathogen whole genome sequencing and classical epidemiological data, can contribute substantially to the disease surveillance and infection prevention activities of local public health authorities (LPHAs).AimOur aim was to characterise how LPHAs use IGS, and factors required or important for their implementation, in the context of the German public health system.MethodsWe employed a mixed-methods design combining a quantitative survey of 60 LPHAs in three German states with five qualitative case studies based on LPHAs in four German localities and one state-level public health authority.ResultsApproximately half of LPHAs reported adoption of IGS; applications included outbreak analysis (n = 25), targeting and evaluation of infection control measures (n = 25 and n = 18, respectively) and characterisation of pathogen transmission chains (n = 25). Factors identified as required or important for the implementation of IGS in LPHAs included fast sample-to-result turnaround times, organisational data interpretation capabilities and clearly defined surveillance sampling strategies. Based on the case studies in which the adoption of IGS was successful, we formulate recommendations for implementing IGS at the level of LPHAs, including establishment of dedicated IGS analysis teams within LPHAs, use of user-friendly digital solutions (e.g. browser-based dashboards) for data exchange and analysis, and implementation of IGS in collaboration with local academic institutions.ConclusionOur analysis paves the way for increasing the implementation of IGS by LPHAs in Germany and other countries with similarly structured public health systems.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic inequalities in the epidemiology and vaccine uptake within a large outbreak of measles in Birmingham, England, 2023 to 2024.","authors":"Hannah Jary, Adam Pullen, David Howett, Erjola Hani, Shakeel Suleman, Lisa Byrne, Emma Booth, Richard Puleston, Vanessa Saliba, Colin Nj Campbell, Carol Chatt","doi":"10.2807/1560-7917.ES.2025.30.16.2400652","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.16.2400652","url":null,"abstract":"<p><p>Measles disproportionately affects under-vaccinated communities, and inequalities in vaccination coverage exist in the United Kingdom (UK). In Birmingham, England, 406 confirmed measles cases were notified to the UK Health Security Agency between 13 October 2023 and 12 April 2024. Public health case management system data and primary care vaccination data were used to describe the epidemiology of the outbreak. Cases had a median age of 5.5 years (interquartile range (IQR): 1-13); 53% (214/406) were male, 45% (183/406) female and sex was unknown for 2% (9/406). Most cases (89%; 362/406) were unvaccinated. While 78% (315/406) of cases occurred in the city's most deprived areas (quintile 1), none did in the least deprived. The measles rate per 100,000 was 47.6 in quintile 1 vs 13.8 in quintile 3. Across ethnicities, the rate was 86.3 in Black African vs 10.8 in White British. Increases in vaccination rates between the outbreak period and an equivalent prior non-outbreak period seemed higher in most deprived populations (0.5% in quintile 1 vs 0.3% in quintiles 5). Variations, however, were observed between ethnic groups. In this large outbreak, measles disproportionately affected individuals from socioeconomically deprived backgrounds and ethnic minorities. In underserved communities, continued tailored services and vaccinations are required.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 16","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustaining successes and addressing challenges to vaccination - a continued public health mission.","authors":"Piotr Kramarz, Ines Steffens","doi":"10.2807/1560-7917.ES.2025.30.16.2500284","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.16.2500284","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 16","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12023725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Authors' response: Statistical methodology critique and alternative approaches in H5Nx avian influenza seroprevalence study among French cats.","authors":"Brandon Hayes, Pierre Bessière, Jean-Luc Guérin","doi":"10.2807/1560-7917.ES.2025.30.15.2500247","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.15.2500247","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 15","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fulminant infective endocarditis with toxin-negative <i>Corynebacterium diphtheriae</i> in people with substance use experiencing homelessness, England, 2024 to 2025.","authors":"Tara Patel, Tasnim Anwar, Eleni Mavrogiorgou, Natasa Utjesanovic, Anna Aryee, David J Litt, Joshua C D'Aeth, Christopher Primus, Satya Das, Nikolaos Karogiannis, Karthik Paranthaman, Gayatri Amirthalingam, Rebecca Cordery","doi":"10.2807/1560-7917.ES.2025.30.13.2500148","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2500148","url":null,"abstract":"<p><p>Between July 2024 and January 2025, five male patients in their early 20s to early 50s were confirmed with infective endocarditis associated with non-toxigenic <i>Corynebacterium diphtheriae</i> in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of routine prophylaxis with monoclonal antibodies and maternal immunisation to prevent respiratory syncytial virus hospitalisations, Lombardy region, Italy, 2024/25 season.","authors":"Francesco Menegale, Luigi Vezzosi, Marcello Tirani, Simona Scarioni, Stefano Odelli, Federica Morani, Catia Borriello, Elena Pariani, Ilaria Dorigatti, Danilo Cereda, Stefano Merler, Piero Poletti","doi":"10.2807/1560-7917.ES.2025.30.14.2400637","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.14.2400637","url":null,"abstract":"<p><p>BackgroundRespiratory syncytial virus (RSV) is a leading cause of hospitalisation in children worldwide. Recent regulatory approval of monoclonal antibody (mAb) nirsevimab for infants and the RSVpreF vaccine for pregnant women offers promising approaches to mitigate RSV-associated morbidity.AimTo evaluate potential impacts of routine prophylactic campaigns (mAbs targeting infants or maternal vaccination) introduced in the 2024/25 season on hospitalisations from RSV lower respiratory tract infections in Lombardy, Italy.MethodsWe used a catalytic model informed by data from pre-COVID-19 pandemic (before 2020) and post-pandemic periods (until 2022) to quantify the number of cases and hospitalisations that could be averted by seasonal nirsevimab administration to infants and RSVpreF maternal vaccination, considering changes in susceptibility caused by reduced RSV circulation during the pandemic.ResultsAs a marked proportion of RSV hospitalisations occurs in infants aged ≤ 1 year, seasonal mAb administration to 80% of newborns (uptake levels observed in Spain) was estimated to avert 50.2% (95% CI: 43.5-55.8) of hospitalisations in the total population. Coverage levels close to those observed for childhood vaccines (95%) could result in an additional average 18% reduction in hospitalisations. Vaccination of 65% of pregnant women, resembling the diphtheria-tetanus-pertussis vaccine coverage in Lombardy for this population, was estimated to avert 30.5% (95% CI: 19.6-39.7) of hospitalisations. At influenza vaccine coverage (12%), less than 8% of hospitalisations could be averted by maternal immunisation.ConclusionRoutine nirsevimab administration to infants demonstrates clear potential to reduce RSV-associated hospitalisations. Maternal immunisation can help in achieving high protection in at-risk populations.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 14","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11987492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Statistical methodology critique and alternative approaches in H5Nx avian influenza seroprevalence study among French cats.","authors":"Yoshiyasu Takefuji","doi":"10.2807/1560-7917.ES.2025.30.15.2500237","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.15.2500237","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 15","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12007400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}