Eurosurveillance最新文献

{"title":"First results of a national deployment of a fully automated central-line-associated bloodstream infection (CLABSI) surveillance system, Switzerland, 2022 to 2023.","authors":"Gaud Catho, Jason Toko, Loïc Fortchantre, Elia Lo Priore, Carlo Balmelli, Lauro Damonti, Philipp Jent, Estelle Moulin, Bruno Grandbastien, Peter W Schreiber, Sarah Tschudin-Sutter, Jan Adam Roth, Lorenzo Ciullini, Claudine Reiber, Walter Zingg, Alexandra U Scherrer, Stephan Harbarth, Niccolò Buetti","doi":"10.2807/1560-7917.ES.2026.31.18.2500650","DOIUrl":"10.2807/1560-7917.ES.2026.31.18.2500650","url":null,"abstract":"<p><p>BACKGROUNDAccurate, fully automated systems may increase efficiency of healthcare-associated infections (HAI) surveillance.AIMWe aimed to validate the performance of a fully automated surveillance system for central-line-associated bloodstream infections (CLABSI) in critically ill patients in Switzerland.METHODSWe conducted a multicentre retrospective study across six secondary and tertiary care hospital networks' intensive care units (ICU). A centrally hosted, fully automated algorithm was implemented to detect catheter-related bloodstream infections (CRBSI), CLABSI and ICU-onset bloodstream infections (ICU-BSI). Algorithm performance was validated against an anonymised manual review of random samples of positive blood cultures. Incidence data were computed for each hospital.RESULTSFrom January 2022 to December 2023, we analysed 131,166 patient days, 108,719 catheter days and 7,832 positive blood cultures from 1,931 ICU patients. Median age was 65 years (interquartile range (IQR): 53-73), 458 (23.7%) were female. For CLABSI and CRBSI, the algorithm demonstrated a specificity of 95.3% (95% confidence interval (CI): 92.7-97.0), sensitivity of 86.5% (95% CI: 79.8-91.2), positive predictive value of 87.0% (95% CI: 80.4-91.7) and negative predictive value of 95.1% (95% CI: 92.5-96.8). CRBSI/CLABSI and ICU-BSI incidence rates were 3.23/1,000 catheter days (95% CI: 2.91-3.57) and 2.42/1,000 patient days (95% CI: 2.17-2.70), respectively. Most identified microorganisms for CRBSI/CLABSI were <i>Staphylococcus epidermidis</i> (15.1%; 53/351), <i>Enterococcus faecium</i> (9.1%; 32/351) and <i>E. faecalis</i> (5.7%; 20/351).CONCLUSIONSWe demonstrate feasibility and external validity of a fully automated system for CLABSI surveillance in critically ill patients, supporting its integration into national HAI prevention and control strategies.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 18","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global influenza epidemiology after 2020: patterns of circulation, epidemic timing and duration, and implications for vaccination strategies.","authors":"Marco Del Riccio, Saverio Caini","doi":"10.2807/1560-7917.ES.2026.31.21.2500743","DOIUrl":"10.2807/1560-7917.ES.2026.31.21.2500743","url":null,"abstract":"<p><p>INTRODUCTIONThere remains uncertainty whether global influenza seasonality, viral dynamics and epidemic duration have re-established after 2021.AIMWe describe global circulation patterns of influenza viruses from 2021 to 2025 and discuss implications for prevention and surveillance.METHODSWe analysed World Health Organization (WHO) FluNet sentinel and non-sentinel/not-defined virological data from week 1/2021 to 26/2025, stratifying by latitude, region and season. We calculated influenza positivity rate, proportion of virus (sub)types, typical peak timing and duration of influenza epidemics (applying the 75% annual average percentage method).RESULTSSentinel surveillance in 120 countries reported 500,870 detections in this period; positivity rate rose globally from 3.0% in 2021 to 23.7% in 2024. Type A viruses caused over two-thirds of cases, with variability across WHO Regions and seasons. Among A subtypes, A(H3N2) dominated in 2021/22 and A(H1N1)pdm09 in 2023/24, while all but three influenza B cases were B/Victoria. Epidemic peaks typically occurred from December to March and May to August in northern and southern hemispheres countries, respectively, while tropical countries showed highly heterogeneous timing. The median epidemic duration was ca 10 weeks above 30° north, and it varied between 15 and 30 weeks at more southern latitudes. Non-sentinel/not-defined feeds showed stronger A-skew and lower characterisation.CONCLUSIONInfluenza virus circulation shows convergence toward seasonal architectures described before the COVID-19 pandemic, although changes in lineage ecology and epidemic duration persist. Our results confirm the need for latitude-tailored vaccination schedules, consolidation of trivalent vaccines, and strengthened surveillance to better anticipate changes in influenza circulation and support preparedness.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 21","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13221616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extensively drug-resistant (XDR) <i>Neisseria gonorrhoeae</i> cured with ceftriaxone 2 g intravenous monotherapy in Croatia, March 2026.","authors":"Tajana Juzbašić, Tatjana Nemeth Blažić, Nilia Volarević, Ivana Bešlić, Daniela Glažar Ivče, Ivana Ferenčak, Dragan Jurić, Ljiljana Žmak, Dolores Peruč, Susanne Jacobsson, Daniel Golparian, Ivana Božičević, Iskra Alexandra Nola, Magnus Unemo","doi":"10.2807/1560-7917.ES.2026.31.21.2600422","DOIUrl":"10.2807/1560-7917.ES.2026.31.21.2600422","url":null,"abstract":"<p><p>In early 2026 in Croatia, a male heterosexual patient of Croatian origin was diagnosed with extensively drug-resistant (XDR) gonorrhoea after unprotected vaginal intercourse with a Croatian female. The <i>Neisseria gonorrhoeae</i> HR027 isolate (genomic lineage B, MLST sequence type (ST)9903) exhibited high-level azithromycin, ceftriaxone, cefixime, benzylpenicillin, ciprofloxacin and tetracycline resistance. It had the mosaic <i>penA</i>-60.001 allele, and A2045G mutations in 23S rRNA. A single dose of ceftriaxone 2 g administered intravenously cured the infection. HR027 showed zoliflodacin and gepotidacin wild-type minimum inhibitory concentrations.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 21","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13235652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state and potential of hospitals for automated healthcare-associated infection surveillance: data from 24 European countries, 2022 to 2023.","authors":"Ferenc Darius Rüther, Mariana Guedes, Elisabeth Presterl, Carl Suetens, Diamantis Plachouras, Maaike Sm van Mourik, Stephanie van Rooden","doi":"10.2807/1560-7917.ES.2026.31.19.2500736","DOIUrl":"10.2807/1560-7917.ES.2026.31.19.2500736","url":null,"abstract":"<p><p>BACKGROUNDAlthough electronic health records are increasingly used for automated surveillance (AS) of healthcare-associated infections (HAIs), implementation is still a challenge. To develop more targeted implementation initiatives across Europe, knowledge about the current state of AS and potential to implement AS systems is needed.AIMTo assess the adoption and feasibility of AS based on the 2022-2023 European Centre for Disease Prevention and Control (ECDC) Point Prevalence Survey (PPS).METHODSThe 2022-2023 ECDC PPS included questions on the degree of AS and digital data storage for seven HAIs. Descriptive analyses of the responses were performed and stratified by geographic region and hospital characteristics. Categorical variables were analysed as such and converted to ordinal scales.RESULTSOverall, 992 hospitals from 24 European countries participated. Across all seven HAIs, fully manual surveillance was the most common method (from healthcare-associated pneumonia (HAP) 38.8% to <i>Clostridioides difficile</i> infection (CDI) 45.4%). A considerable proportion, i.e. 19.3% (HAP) to 29.8% (CDI), employed some form of automation (automated denominator 5.3-11.3%; semi-automated 12.2-16.9%; fully automated 1.8-2.9%). Many hospitals not employing AS had required source data digitally stored. Generally, tertiary hospitals had higher levels of automation and digital data storage compared with other hospital types. Smaller hospitals (≤ 250 beds) had lower levels of automation, but a similar level of digital data storage compared with larger hospitals.CONCLUSIONThis study highlights variability in AS implementation and digital potential across European hospitals and underscores the need for targeted strategies to advance AS adoption and optimise surveillance.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 19","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13179479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic landscape of <i>Candidozyma auris</i> in Italy, 2019 to 2025: emerging diversity of clade I sub-lineages associated with inter-facility transmission and cross-border transfers.","authors":"Vincenzo Di Pilato, Edward Willison, Luca Calabrese, Elisa Matarazzo, Laura Magnasco, Elisa Costa, Paola Morici, Daniele Roberto Giacobbe, Chiara Vismara, Malgorzata Mikulska, Gian Maria Rossolini, Matteo Bassetti, Anna Marchese","doi":"10.2807/1560-7917.ES.2026.31.18.2500730","DOIUrl":"10.2807/1560-7917.ES.2026.31.18.2500730","url":null,"abstract":"<p><p>BACKGROUND<i>Candidozyma auris</i> is a fungal pathogen of major concern, that frequently exhibits multidrug resistance and causes healthcare-related outbreaks worldwide. Italy experienced a large nosocomial outbreak in early 2020, with subsequent sporadic cases or small clusters in different regions.AIMTo provide an overview of the <i>C. auris</i> population structure, genomic diversity, and spread in Italy.METHODSGenome sequences from Italian <i>C. auris</i> isolates (n = 68) were obtained either from public databases, or by whole-genome sequencing of available isolates (n = 17) from previously uncharacterised and/or recently emerged (2025) cases. The sequence dataset was complemented with whole genome sequences of international isolates (n = 139) to conduct a global phylogenetic analysis based on core-genome single nucleotide polymorphisms. Genetic mutations associated with antifungal resistance were investigated.RESULTSAll Italian isolates belonged to clade I (South Asian) but were interspersed among different subclades. Subclade Ic isolates were of a single lineage, characterised by the <i>HMG1</i>P238H mutation. This lineage spread over four regions. Subclade Ib members were more diverse, and associated with local or imported single cases, as well as nosocomial clusters following sporadic, independent <i>C. auris</i> introductions from countries in southern Europe. A putative new subclade (Id) was identified, involving isolates from Italy and an eastern European country. Subclades Ib-c-d exhibited lineage-specific genetic signatures in antifungal-resistance-associated loci (<i>CDR1, ERG11, TAC1B</i>).CONCLUSIONSIn Italy, <i>C. auris</i> strains form a complex population, resulting from emergence or evolution of clade I sub-lineages following, in some instances, sporadic introductions from other European countries. Strengthened screening protocols remain essential for inter-facility transfers and for patients with prior healthcare exposure abroad.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 18","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-reactive human antibody responses to H9N2 influenza virus, New York, United States, 2025.","authors":"Gagandeep Singh, Disha Bhavsar, Lucas M Ferreri, Jessica R Nardulli, Charles Gleason, Neko Lyttle, Yuexing Chen, Anice C Lowen, Viviana Simon, Florian Krammer","doi":"10.2807/1560-7917.ES.2026.31.20.2600375","DOIUrl":"10.2807/1560-7917.ES.2026.31.20.2600375","url":null,"abstract":"<p><p>Understanding population immunity to emerging viruses is critical for risk assessment. We characterised antibody responses to avian influenza A(H9N2) viruses in 298 human sera from adults in New York City. We observed widespread cross-reactive H9-binding antibodies, albeit at lower levels (GMT = 371.3) than against seasonal H3 (GMT = 1,398.0), with low to undetectable haemagglutination inhibition and neutralising antibodies. In contrast, NA-binding and neuraminidase inhibition responses were moderate (GMT = 149.5 and 34.2) and comparable to those against human seasonal N2 (GMT = 259.0 and 42.2).</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 20","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of chikungunya viral transmission, French Guiana, 2026.","authors":"Marion Petit Sinturel, Dominique Rousset, Antoine Enfissi, Tsiriniaina Ramavoson, Crepin Kezza, Frédéric Jourdain, Félix Djossou, Tiphanie Succo","doi":"10.2807/1560-7917.ES.2026.31.20.2600296","DOIUrl":"10.2807/1560-7917.ES.2026.31.20.2600296","url":null,"abstract":"<p><p>In January 2026, French Guiana detected its first confirmed chikungunya case, initiating a second outbreak after the first one which occurred in 2014/15. The expected seroprevalence for 2026 is estimated at 16.2%, with the virus likely spreading eastward from the west of French Guiana. The causative East/Central/South African (ECSA) strain, lacking the vector-adaptive E1-A226V mutation, may reduce transmission risk in mainland France and Europe, but Caribbean Islands remain vulnerable due to the vector's presence.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 20","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197738/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surveillance of invasive pneumococcal disease in Germany: surge in PCV13 serotypes and new challenges, 2017 to 2024.","authors":"Mark Pg van der Linden, Mathias W Pletz, Andreas Itzek","doi":"10.2807/1560-7917.ES.2026.31.21.2500576","DOIUrl":"10.2807/1560-7917.ES.2026.31.21.2500576","url":null,"abstract":"<p><p>BACKGROUNDPneumococcal vaccination has been recommended in Germany for adults aged ≥ 60 years (1998) and children aged < 2 years (2006), resulting in a reduction of pneumococcal disease incidence in vaccinated children and unvaccinated individuals through herd protection.AIMWe aimed to investigate serotype distribution of invasive pneumococcal disease (IPD) among children and adults in 2017-2024.METHODSWe analysed data of an ongoing nationwide surveillance of IPD. All isolates were serotyped by Neufeld's Quellung reaction.RESULTSIn total, 24,122 IPD isolates were analysed by the German Reference Laboratory for Streptococci. Over the study period, case numbers were lower during the COVID-19 pandemic and increased afterwards with higher proportion of pneumococcal conjugate vaccine (PCV)13 serotypes. Serotypes 22F and 33F, included in PCV15 and PCV20, showed only minor variations, whereas PCV20 unique serotypes were less frequently observed in 2022-2024. Serotype 3 persisted in IPD across all age groups, while serotype 4 disappeared in children and adolescents, but increased in adults, most prominently in 18-49-year-olds. Serotype 38 steeply increased in 2023/24, among children aged < 2 years and older adults.CONCLUSIONThe concerning increase of PCV13 serotype IPD in Germany might be related to low vaccination uptake, resulting in inefficient herd protection. The dominance of serotype 3 and the rise of serotype 4 among adults highlight the importance of direct protection and support the current national vaccination recommendation for adults aged ≥ 60 years. The increase in serotype 38 IPD among young children and older adults might indicate a replacement phenomenon, highlighting the importance of IPD serotype surveillance.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 21","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13221618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148053698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeted monitoring informed by mapping the ongoing spread of tick-borne encephalitis virus, the Netherlands.","authors":"Sara R Wijburg, Dedeke Rockx-Brouwer, Megan K Herbert, Jolianne M Rijks, Paulina M Lesiczka, Miriam Maas, Andrea Gröne, Renate W Hakze-van der Honing, Maya Holding, Helen J Esser, Hein Sprong, Egil Aj Fischer","doi":"10.2807/1560-7917.ES.2026.31.20.2500767","DOIUrl":"10.2807/1560-7917.ES.2026.31.20.2500767","url":null,"abstract":"<p><p>BACKGROUNDTick-borne encephalitis virus (TBEV) was detected in the Netherlands in 2015. Current monitoring through serology in deer, tick collection and reported human cases, may underestimate areas of virus circulation. Including estimates of suitability of the habitat for TBEV can guide risk-based monitoring.AIMWe aimed to improve the accuracy of the TBEV distribution map by adding estimates of TBEV habitat suitability to guide targeted tick monitoring in newly identified risk regions.METHODSHabitat suitability for TBEV was assessed by calculating the basic reproduction number (R₀) for 1 km2 grid cells aggregating various data sources for tick hosts such as mice or voles, tick abundance and TBEV transmission. The importance of different tick hosts was determined in scenario analyses. The baseline scenario was validated against data on seropositive roe deer and TBEV-positive ticks and rodents.RESULTSThe suitability (R₀ ≥ 1) was associated with tick habitat suitability and the abundance of competent host species. Variation in competent host densities had a greater effect on R₀ estimates than incompetent hosts. Monitoring data corresponded well with model-predicted high-risk areas and confirmed further spread of TBEV.CONCLUSIONThe TBEV suitability map is a useful tool for targeted sentinel surveillance by identifying new risk areas, informing local municipal health services of endemic areas for potential human exposure. Our results support targeted efforts for awareness, preparedness and outbreak response, even in regions where TBEV has not yet been detected. Integrating One Health monitoring with spatial modelling can strengthen preparedness in emerging TBEV regions.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 20","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13197735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147987193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of carbapenamase production in <i>Shigella flexneri</i> isolated in Ireland, 2025.","authors":"Christina Clarke, Alma Tuohy, Erica Duignan, Paul Mullane, Ann Marie Carolan, Orla Craig, Georgios Miliotis, Christina Dillon, Martin Cormican","doi":"10.2807/1560-7917.ES.2026.31.18.2600351","DOIUrl":"10.2807/1560-7917.ES.2026.31.18.2600351","url":null,"abstract":"<p><p><i>Shigella flexneri</i> producing OXA-181 was detected from a patient in Ireland in October 2025. The isolate had a meropenem minimum inhibitory concentration (MIC) of 0.12 mg/L. Carbapenemase production was detected by lateral flow immunoassay. The sequence type was ST245 and closely related to sequences previously reported from Ireland and other countries but not previously linked to presence of the <i>bla</i> _OXA-181 gene_. Carbapenemase production in <i>Shigella</i> spp. has implications for laboratory detection and empiric treatment.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"31 18","pages":""},"PeriodicalIF":8.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147948163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}