Eurosurveillance最新文献

{"title":"Epidemiology of <i>Staphylococcus haemolyticus</i> nosocomial bacteraemia in neonatal intensive care units, France, 2019 to 2023: predominance of the ST29 (CC3) multidrug-resistant lineage.","authors":"Patricia Martins Simões, Nathalie van der Mee-Marquet, Benjamin Youenou, Anne-Gaelle Ranc, Céline Dupieux-Chabert, Guillaume Menard, Clarisse Dupin, Marine Butin, François Vandenesch, Frédéric Laurent, Anne Berger-Carbonne, Camille Kolenda, Anne Tristan","doi":"10.2807/1560-7917.ES.2025.30.11.2400309","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.2400309","url":null,"abstract":"<p><p>Background<i>Staphylococcus haemolyticus</i> (SH) is an opportunistic pathogen associated with nosocomial infections, particularly bacteraemia in neonates. Epidemiological trends and genetic diversity of these infections worldwide are largely unknown.AimTo investigate an increase in SH vascular catheter-related bacteraemia in neonates and describe the molecular epidemiology in France between 2019 and 2023.MethodsWe analysed clinical and microbiological surveillance data from the French national surveillance network for central catheter-related (venous and umbilical) infections between 2019 and 2023. We also performed genomic and phylogenetic analyses of 496 strains isolated both inside (n = 383 from neonates, staff and environmental samples) and outside (n = 113 from adults) the neonatal intensive care unit (NICU) settings.ResultsThe proportion of SH among the 474 reported cases of nosocomial bacteraemia increased from about 20% to 30% over 5 years, mainly affecting very low birth weight preterm neonates (≤ 1,500 g). The ST29 sequence type (ST) not prevalent in previous studies was predominant, accounting for 74% of NICU strains. ST29 was characterised by phenotypic multidrug resistance to at least six classes of antibiotics (oxacillin, quinolones, gentamicin, cotrimoxazole, clindamycin and rifampicin), which distinguished it with good sensitivity and specificity from other prevalent multidrug-resistant STs identified (ST1 and ST25). ST29 strains more frequently harboured the <i>drfG</i>, <i>vga-LC</i> and <i>mupA</i> genes and a triple point mutation (D471E, I527M and S532N) in the <i>rpoB</i> gene.ConclusionsThe present study highlights the success of a highly resistant ST29 lineage in French NICUs mainly affecting very low birth weight premature neonates.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global meta-analysis of short-term associations between ambient temperature and pathogen-specific respiratory infections, 2004 to 2023.","authors":"Xue Shang, Ruhao Zhang, Junyao Zheng, Yi Luo, Kangle Guo, Qingqing Zhou, Xu Guang, Ning Zhang, Hao Xue, Haidong Wang, Chunfu Yang, Zhen Zhang, Bin Zhu","doi":"10.2807/1560-7917.ES.2025.30.11.2400375","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.2400375","url":null,"abstract":"<p><p>BackgroundAmbient temperature may affect respiratory health, while the temperature sensitivity of respiratory infections may be pathogen-dependent.AimsWe sought to explore pathogen-specific associations between ambient temperature and respiratory infections.MethodsWe searched nine databases for a random-effects meta-analysis to pool the relative risk (RR) of respiratory infection by pathogen per 1° C temperature rise, compared to populations unexposed to the same temperature. We conducted pathogen-specific analyses, sensitivity analyses, subgroup analyses and meta-regression.ResultsA total of 137 studies were eligible for meta-analysis. The pooled and single-study estimates revealed that the incidence of respiratory syncytial virus (RR = 0.14; 95% confidence interval (CI): 0.09-0.23), influenza virus (IV) (RR = 0.40; 95% CI: 0.27-0.61), human metapneumovirus (RR = 0.48; 95% CI: 0.32-0.73), human coronavirus (HCoV) (RR = 0.21; 95% CI: 0.07-0.61) and SARS-CoV-2 (RR = 0.52; 95% CI: 0.35-0.78) decreased per 1° C temperature rise, while that of human parainfluenza virus (HPIV) (RR = 2.35; 95% CI: 1.46-3.77), human bocavirus (HBoV) (RR = 1.86; 95% CI: 1.04-3.32) and MERS-CoV (RR = 1.05; 95% CI: 1.04-1.07) increased. The risk of infection was lower for IVA, IVB, HCoV-229E and HCoV-OC43, while HPIV-3, and HBoV-1 were at increased risk. The risk of <i>Streptococcus pyogenes</i> pharyngitis (RR = 0.46; 95% CI: 0.30-0.69) decreased per 1° C temperature rise, while <i>Pseudomonas aeruginosa</i> (RR = 1.04; 95% CI: 1.03-1.05) and <i>Legionella pneumophila</i> infections (RR = 2.69; 95% CI: 1.11-6.53) increased.ConclusionsTemperature sensitivity of respiratory infections can vary with the specific pathogen type and subtype that causes the infection. As the climatic conditions will become warmer, public health policy makers should act to develop pathogen adaptation strategies.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case series of the first five human infections with monkeypox virus clade Ib and report on the public health response, United Kingdom, October to November 2024.","authors":"Muhammad Ibaad Alvi, Merav Kliner, William Welfare, N Claire Gordon, Sherine Thomas, Simon Padfield, Hannah E Emmett, Ellen Heinsbroek, Gareth J Hughes, Natalie Groves, Eileen Gallagher, Steven Pullan, Amy Belfield, Catherine F Houlihan, Tommy Rampling, Geraldine O'Hara, Anne Tunbridge, Jake Dunning, Elizabeth Whittaker, Alejandra Alonso, Mike Beadsworth, Brendan Ai Payne, Meera Chand, Susan Hopkins, Gillian Armstrong","doi":"10.2807/1560-7917.ES.2025.30.10.2500131","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2500131","url":null,"abstract":"<p><p>We report two importations of monkeypox virus clade Ib infection to the United Kingdom in 2024. The first was a traveller returning from Tanzania, Rwanda and Uganda, the second from Uganda. Both presented with fever and typical skin lesions; 147 contacts were followed up, 19 vaccinated with MVA-BN. Three household contacts of the first individual, including two children, became infected. These are the first reported autochthonous transmissions of clade Ib in Europe, and first paediatric cases outside the African continent.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case report of a cat infected with European bat lyssavirus type 1, the Netherlands, October 2024.","authors":"Phaedra Eblé, Aldo Dekker, Sanne van den End, Vanessa Visser, Marc Engelsma, Frank Harders, Lucien van Keulen, Erik van Weezep, Melle Holwerda","doi":"10.2807/1560-7917.ES.2025.30.10.2500154","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2500154","url":null,"abstract":"<p><p>In October 2024, an infection of European bat lyssavirus type 1 was confirmed in a domestic cat in the Netherlands. Several weeks before, the owners had found a dead bat considered to be caught by the cat. Nine persons exposed to the cat received post-exposure prophylaxis and four domestic animals from the same household were quarantined. This report stresses the need for vigilance for rabies in domestic animals in countries where lyssavirus infections in bats are endemic.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National survey of the rat hepatitis E virus in rodents in Spain, 2022 to 2023.","authors":"Javier Caballero-Gómez, Tomás Fajardo-Alonso, Lucía Ríos-Muñoz, Adrián Beato-Benítez, María Casares-Jiménez, Ignacio García-Bocanegra, Raúl Cuadrado-Matías, Alba Martí-Marco, Javier Martínez, Remigio Martínez, Eva Martínez Nevado, Francisco Ruiz-Fons, João Rodrigo Mesquita, Màrius Fuentes, Diana Corona-Mata, Moisés Gonzálvez, Víctor Lizana, Pilar Soriano, Pilar Foronda, Dietmar Crailsheim, Antonio Rivero-Juárez, Antonio Rivero","doi":"10.2807/1560-7917.ES.2025.30.12.2400473","DOIUrl":"10.2807/1560-7917.ES.2025.30.12.2400473","url":null,"abstract":"<p><p>BackgroundRat hepatitis E virus (ratHEV) is an emerging virus causing acute and chronic hepatitis in humans. Rats are the main natural reservoir of this pathogen. Large-scale studies assessing ratHEV circulation in rodents in Spain are lacking.AimWe aimed to determine the prevalence of ratHEV in rats in Spain and evaluate potential transmission risk to humans.MethodsWe designed a cross-sectional nationwide study where black (<i>Rattus rattus</i>) and Norway (<i>R. norvegicus</i>) rats were collected and analysed between 2022 and 2023 for ratHEV infection using real-time (RT)-qPCR testing of liver tissue. Sequencing and analysis of ratHEV shedding in faeces were carried out in positive animals.ResultsRatHEV was detected in 125 of the 481 rats analysed, supposing a prevalence of 26.0% (95 CI%: 22.3-30.1). Positive rats were found in urban (25.6%), and farm (29.8%) settings. Black rats (31.3%) had 1.5 times higher odds of being infected by the virus than Norway rats (22.5%) (p = 0.049). Significantly higher prevalence of ratHEV was detected in rodents sampled from southern (31.9%) than northern (17.8%) Spain (p = 0.003). Viral RNA was detected in faeces from 45.5% of infected rats. Phylogenetic analysis evidenced a wide genetic diversity of ratHEV sequences, some showing high homology with ratHEV strains found in patients from Spain.ConclusionsCirculation of ratHEV appears to be heterogeneous and the virus appears to be endemic among rat populations in Spain, highlighting the possible risk of zoonotic transmission of this emerging virus in this country.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 12","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of SARS-CoV-2 variant mutations on susceptibility to monoclonal antibodies and antiviral drugs: a non-systematic review, April 2022 to October 2024.","authors":"Maja Vukovikj, Angeliki Melidou, Priyanka Nannapaneni, Tanja Normark, Annette Kraus, Eeva K Broberg","doi":"10.2807/1560-7917.ES.2025.30.10.2400252","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2400252","url":null,"abstract":"<p><p>BackgroundMonoclonal antibodies (mAbs) and antiviral drugs have emerged as additional tools for treatment of COVID-19.AimWe aimed to review data on susceptibility of 14 SARS-CoV-2 variants to mAbs and antiviral drugs authorised in the European Union/European Economic Area (EU/EEA) countries.MethodsWe constructed a literature review compiling 298 publications from four databases: PubMed, Science Direct, LitCovid and BioRxiv/MedRxiv preprint servers. We included publications on nirmatrelvir and ritonavir, remdesivir and tixagevimab and cilgavimab, regdanvimab, casirivimab and imdevimab, and sotrovimab approved by the European Medicines Agency (EMA) by 1 October 2024.ResultsThe mutations identified in the open reading frame (ORF)1ab, specifically nsp5:H172Y, nsp5:H172Y and Q189E, nsp5:L50F and E166V and nsp5:L50F, E166A and L167V, led to a decrease in susceptibility to nirmatrelvir and ritonavir, ranging from moderate (25-99) to high reductions (> 100). Casirivimab and imdevimab exhibited highly reduced neutralisation capacity across all Omicron sub-lineages. Sub-lineages BA.1, BA.2 and BA.5 had decreased susceptibility to regdanvimab, while sotrovimab showed decreased efficacy for BA.2, BA.4, BQ.1.1 and BA.2.86. Tixagevimab and cilgavimab exhibited highly reduced neutralisation activity against BQ.1, BQ.1.1, XBB, XBB.1.5 and BA.2.86 sub-lineages.ConclusionsThe emergence of new variants, some with altered antigenic characteristics, may lead to resistance against mAbs and/or antiviral drugs and evasion of immunity induced naturally or by vaccination. This summary of mutations, combination of mutations and SARS-CoV-2 variants linked to reduced susceptibility to mAbs and antiviral drugs, should aid the selection of appropriate treatment strategies and/or phasing out therapies that have lost their effectiveness.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisation due to respiratory syncytial virus in a population-based cohort of older adults in Spain, 2016/17 to 2019/20.","authors":"Noelia Vera-Punzano, Camino Trobajo-Sanmartín, Ana Navascués, Aitziber Echeverria, Itziar Casado, Carmen Ezpeleta, Jesús Castilla, Iván Martínez-Baz","doi":"10.2807/1560-7917.ES.2025.30.10.2400364","DOIUrl":"10.2807/1560-7917.ES.2025.30.10.2400364","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 10","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for Euro Surveill. 2025;30(7).","authors":"","doi":"10.2807/1560-7917.ES.2025.30.11.240320c","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.240320c","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"14 years of rotavirus A surveillance: unusual dominance of equine-like G3P[8] genotype with DS-1-like genotype constellation after the pandemic, Belgium, 2009 to 2023.","authors":"Mustafa Karataş, Mandy Bloemen, Lize Cuypers, Elke Wollants, Marc Van Ranst, Jelle Matthijnssens","doi":"10.2807/1560-7917.ES.2025.30.12.2400442","DOIUrl":"10.2807/1560-7917.ES.2025.30.12.2400442","url":null,"abstract":"<p><p>IntroductionDespite vaccine availability, rotavirus persists as a leading cause of gastroenteritis in children younger than 5 years.AimWe aimed to evaluate temporal changes in rotavirus epidemiology in Belgium between 2009 and 2023, including the period of the COVID-19 pandemic.MethodsWe collected 8,024 rotavirus-positive stool samples throughout Belgium. For 6,352 samples, we determined the G and/or P genotypes through sequencing of the genes encoding the outer capsid proteins VP7 and VP4.ResultsBefore the COVID-19pandemic, we received on average 622 samples per rotavirus epidemiological year, which decreased to 114 and 111 samples during the two pandemic rotavirus epidemiological years, followed by a peak of 1,048 samples in the first post-pandemic year. Notably, the proportion of cases in the age group 2-5-years increased from 20.3% before to 33% after the pandemic (p < 0.001). Over the 14-year study period, the most common genotypes were G2P[4], G3P[8] and G9P[8]. Post-pandemic data show an unusually strong dominance of the equine-like G3P[8] genotype which carried a DS-1-like genotype constellation in the period 2021 to 2023. Additionally, vaccinated individuals were significantly overrepresented among patients infected with the equine-like VP7 carrying G3P[8] rotavirus compared with other genotypes, including typical human VP7 G3P[8].ConclusionDespite the presence of typical yearly genotype fluctuations, several epidemiological changes were associated with the COVID-19 pandemic, including the unusual dominance of an emerging rotavirus strain against which current vaccines may be less effective. It is essential to closely monitor this strain to determine if the phenomenon is temporary.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 12","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tuberculosis rates in migrants in low-incidence European countries, according to country of origin, reporting country and recency of immigration, 2014 to 2020.","authors":"Teresa Domaszewska, Anders Koch, Sarah Jackson, Brit Häcker, Jerker Jonsson, Kristina Langholz Kristensen, Hanna Soini, Wouter Arrazola de Oñate, Jean-Paul Guthmann, Barbara Hauer, Mary O Meara, Karine Nordstrand, Vinciane Sizaire, Gerard de Vries","doi":"10.2807/1560-7917.ES.2025.30.11.2400489","DOIUrl":"10.2807/1560-7917.ES.2025.30.11.2400489","url":null,"abstract":"<p><p>BackgroundAs tuberculosis (TB) incidence rates decrease faster in native than migrant populations in European countries, addressing migrant health becomes increasingly important in TB programmes.AimTo inform European TB prevention and control policies, we analysed data on TB in migrants in low TB-incidence European countries (TB incidence < 10/100,000 population) during 2014-2020 by migrant origin, destination, and recent vs non-recent immigration.MethodsData on migrant TB patients were derived from the European Surveillance System (TESSy) and data on migrant populations from Eurostat or national statistical offices. We calculated annual migrant TB crude incidence rates (CIRs) per country of origin, destination country and year, for all migrants with TB and recently arrived migrants with TB, the latter defined by TB diagnosis within 1 year after arrival in the destination country.ResultsIn 2014-2020, 104,371 migrants with TB were reported to TESSy by 20 destination countries. Average annual migrant CIRs were highest in the United Kingdom (43/100,000). Origin countries of most migrant TB patients were India (n = 9,561), Romania (n = 8,345), and Pakistan (n = 7,300). The highest CIRs were found among migrants from Eritrea (480/100,000), Somalia (414/100,000) and The Gambia (343/100,000), and were higher than estimated World Health Organization incidences for those countries. The CIRs among recently arrived migrants appeared higher than in the overall migrant population.ConclusionsWe found substantially higher CIRs in certain migrant subpopulations than others. TB rates in recent migrants appeared to be up to 11 times higher than in corresponding origin countries. Tailored and regularly adapted TB prevention and control strategies are needed.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 11","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}