Eurosurveillance最新文献

{"title":"Likelihood of HIV and recent bacterial sexually transmitted infections among transgender and non-binary individuals in 20 European countries, October 2023 to April 2024.","authors":"Haoyi Wang, Johann Kolstee, Jules L Casalini, Samira Hakim, Hanne Ml Zimmermann, Kai J Jonas","doi":"10.2807/1560-7917.ES.2024.29.48.2400347","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400347","url":null,"abstract":"<p><p>BackgroundGlobal data highlight the disproportionate burden of HIV and sexually transmitted infections (STIs) among transgender individuals. However, scant data exist for both transgender and non-binary individuals in European HIV/STI surveillance.AimTo assess self-reported prevalence of HIV and bacterial STIs (syphilis, gonorrhoea, chlamydia) in the past 6 months among transgender and non-binary individuals, comparing the likelihoods of recent STIs between groups.MethodsUsing data from the cross-sectional PROTECT survey conducted in 20 European countries from October 2023 to April 2024, we analysed a subset of 452 participants, 178 transgender and 274 non-binary individuals. Logistic regression was used to compare the risk of each recent bacterial STI, and Poisson regression to compare the risk of the number of recent STIs.ResultsAmong transgender individuals, 5 (2.8%) self-reported HIV infection, and recent STI prevalence was 6.7% for syphilis, 15.6% for gonorrhoea and 19.6% for chlamydia. For non-binary individuals, 15 (5.5%) self-reported HIV infection and recent STI prevalence was 15.0% for syphilis, 18.7% for gonorrhoea and 20.8% for chlamydia. Non-binary individuals had significantly higher risk for syphilis (aOR: 1.81; 95% CI: 1.01-4.05) and multiple recent STIs (aOR: 1.46; 95% CI: 1.11-1.91) compared with transgender individuals.ConclusionWhile both transgender and non-binary individuals showed high self-reported prevalence of HIV and bacterial STIs, non-binary individuals showed greater prevalence of STIs, particularly syphilis. Efforts aimed at HIV/STI prevention and surveillance should encourage inclusion of those who identify as non-binary and other gender-diverse individuals alongside transgender individuals to enhance the provision of tailored prevention and treatment services in Europe.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of circulating type 3 vaccine-derived polioviruses in French Guiana, May to August 2024.","authors":"Stéphanie Raffestin, Ambre Tinard, Antoine Enfissi, Marie-Line Joffret, Timothée Lichtenstein, Sourakhata Tirera, Laura Zanetti, Marie Barrau, Francky Mubenga, Adrien Ortelli, Christophe N Peyrefitte, Anne Lavergne, Dominique Rousset, Maël Bessaud","doi":"10.2807/1560-7917.ES.2024.29.45.2400705","DOIUrl":"10.2807/1560-7917.ES.2024.29.45.2400705","url":null,"abstract":"<p><p>Circulating type 3 vaccine-derived polioviruses (cVDPV3s) were detected in three wastewater samples collected in French Guiana from May through August 2024. As the oral polio vaccine is not used in French Guiana, this event involved an import either of cVDPV3s themselves or of a vaccine strain from which the cVDPV3s emerged in French Guiana. This highlights the importance of environmental surveillance for the detection of silent poliovirus circulation. Eliminating any pockets of cVDPVs is crucial for the polio eradication programme.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 45","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agile, on-demand wastewater surveillance of virus infections to support pandemic and outbreak response in Rotterdam-Rijnmond, the Netherlands, 2020 to 2022.","authors":"Emma Besijn, Jane Whelan, Paul Bijkerk, Gregorius J Sips, Jeroen Langeveld, Ray W Izquierdo-Lara, Elvira van Baarle, Remy Schilperoort, Marion P G Koopmans, Miranda de Graaf, Gertjan Medema, Ewout Fanoy","doi":"10.2807/1560-7917.ES.2024.29.47.2400055","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400055","url":null,"abstract":"<p><p>BackgroundWastewater surveillance may support early and comprehensive detection of infectious diseases' community transmission, particularly in settings where other health surveillance systems provide biased or limited information. Amid the SARS-CoV-2 pandemic, deploying passive samplers to monitor targeted populations gained importance. Evaluation of the added public health value of this approach in the field can support its broader adoption.AimWe aimed to assess the feasibility and utility of on-demand wastewater surveillance, employing passive samplers, for SARS-CoV-2 and monkeypox virus (MPXV) in small/targeted populations, also considering ethical aspects.MethodsPilot case studies in the Rotterdam-Rijnmond region were used for a systematic assessment of the feasibility and utility of wastewater monitoring of SARS-CoV-2 (variants) and MPXV using passive sampling. Each case study was instigated by actual questions from the Public Health Service about disease transmission.ResultsCase study results demonstrated the feasibility and utility of on-demand wastewater surveillance with successful identification of a local peak in SARS-CoV-2 transmission, early detection of wider Omicron variant transmission after the first case was reported, as well as indication of no emerging local MPXV transmission. Ethical considerations led to the abandonment of one case study involving a displaced population.ConclusionsThe study confirms the feasibility and utility of passive sampling for real-time infectious disease surveillance, at desired spatiotemporal resolution. Ethical concerns and operational challenges were identified, highlighting the need for early stakeholder engagement and ethical guideline adherence. The method could be used to study under-surveyed populations and be extended beyond SARS-CoV-2 and MPXV to other pathogens.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First case of mpox with monkeypox virus clade Ib outside Africa in a returning traveller, Sweden, August 2024: public health measures.","authors":"Carl-Johan Treutiger, Finn Filén, Moa Rehn, Johan Aarum, Andreas Jacks, Magnus Gisslén, Erik Sturegård, Maria Lind Karlberg, Oskar Karlsson Lindsjö, Klara Sondén","doi":"10.2807/1560-7917.ES.2024.29.48.2400740","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400740","url":null,"abstract":"<p><p>An unprecedented upsurge in mpox, caused by clade I of the monkeypox virus (MPXV) was noted in Central Africa in 2024. The first mpox case with MPXV clade Ib outside Africa was reported in Sweden in mid-August. The case experienced a mild disease course after travelling to an affected country. No additional cases of this clade have been detected in Sweden. Strengthened public health measures and surveillance including whole genome sequencing are crucial to prevent establishment of novel MPXV clades.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in new HIV diagnoses and factors contributing to late diagnosis among migrant populations in EU/EEA countries, 2014 to 2023.","authors":"Juliana Reyes-Urueña, Giorgia Stoppa, Federica Pizzolato, Marieke J van der Werf, Charlotte Deogan, Vítor Cabral-Veríssimo, Helena Cortes-Martins, Jessika Deblonde, Asuncion Diaz, Victoria Hernando, Erna Milunka-Kojic, Joël Mossong, Kate O'Donnell, Eline Op de Coul, Chrysa Tsiara, Lilian van Leest, Dominique Van Beckhoven, Maria Wessman, Robert Whittaker","doi":"10.2807/1560-7917.ES.2024.29.48.2400759","DOIUrl":"10.2807/1560-7917.ES.2024.29.48.2400759","url":null,"abstract":"<p><p>We analysed trends in new HIV diagnoses and factors contributing to late diagnosis among migrants in countries in the European Union (EU)/European Economic Area (EEA) from 2014 to 2023. Of the total reported HIV diagnoses, 45.9% were in migrants, with 13.3% born in EU/EEA countries and 86.7% in non-EU/EEA countries. Late diagnosis was observed in 52.4% of migrants, particularly among non-EU/EEA migrants with heterosexual transmission, regardless of sex. Improved HIV prevention and testing strategies are essential for at-risk migrant populations.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 48","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing <i>Providencia stuartii</i> in hospitals, Romania, December 2021 to September 2023.","authors":"Marius Linkevicius, Sandra Witteveen, Mariana Buzea, Mirela Flonta, Marina Indreas, Maria Nica, Edit Székely, Daniela Tălăpan, Olov Svartström, Erik Alm, Daniel Palm, Dominique L Monnet, Antoni Pa Hendrickx, Anke Kohlenberg, Gabriel Adrian Popescu","doi":"10.2807/1560-7917.ES.2024.29.47.2400587","DOIUrl":"10.2807/1560-7917.ES.2024.29.47.2400587","url":null,"abstract":"<p><p>BackgroundNew Delhi metallo-beta-lactamase (NDM)-producing <i>Providencia stuartii</i> has been reported from European Union/European Economic Area (EU/EEA) countries with increasing frequency. During 2018 to 2022, 355 cases of NDM-producing <i>P. stuartii</i> were detected in seven hospitals reporting on NDM-production in Enterobacterales in Romania.AimOur aim was to determine the extent of spread of NDM-producing <i>P. stuartii</i> in hospitals in Romania.MethodsWe analysed whole genome sequences and epidemiological data of 74 <i>P. stuartii</i> isolates collected in six hospitals from December 2021 to September 2023.ResultsWe identified four multi-hospital clusters including isolates detected over more than a year, indicating sustained spread of <i>bla</i> _NDM-1-carrying <i>P. stuartii</i> within the healthcare system. These clusters consisted of isolates from up to four hospitals and three regions. Three multi-hospital clusters were caused by a specific multidrug-resistant <i>P. stuartii</i> sequence type 46 lineage carrying <i>bla</i> _NDM-1 and a large set of additional resistance markers. Investigation in an international context showed that this lineage had already been detected in nine countries (Bulgaria, France, Germany, Ireland, the Netherlands, Romania, Switzerland, United Kingdom, United States) since 2015.ConclusionOur results alert about the risk of carbapenem-resistant <i>P. stuartii</i> transmission in healthcare settings. Enhanced infection prevention and control measures should be instituted as soon as cases are detected in healthcare facilities. National surveillance systems in EU/EEA countries should, in addition to carbapenem-resistant and/or carbapenemase-producing <i>Klebsiella pneumoniae</i> and <i>Escherichia coli</i>, consider reporting carbapenem-resistant and/or carbapenemase-producing <i>P. stuartii</i> and other Enterobacterales where relevant.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 47","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Locally acquired malaria: a retrospective analysis of long-term surveillance data, European France, 1995 to 2022.","authors":"Hugues Delamare, Arnaud Tarantola, Marc Thellier, Clémentine Calba, Olivier Gaget, Paul-Henri Consigny, Frederic Simard, Sylvie Manguin, Elise Brottet, Marie-Claire Paty, Sandrine Houze, Henriette De Valk, Harold Noël","doi":"10.2807/1560-7917.ES.2024.29.41.2400133","DOIUrl":"10.2807/1560-7917.ES.2024.29.41.2400133","url":null,"abstract":"<p><p>BackgroundIn European France, the bulk of malaria cases are travel-related, and only locally acquired cases are notifiable to assess any risk of re-emergence.AimsWe aimed to contribute to assessing the health impact of locally acquired malaria and the potential of malaria re-emergence in European France by documenting modes of transmission of locally acquired malaria, the <i>Plasmodium</i> species involved and their incidence trends.MethodsWe retrospectively analysed surveillance and case investigation data on locally acquired malaria from 1995 to 2022. We classified cases by most likely mode of transmission using a classification derived from the European Centre for Disease Prevention and Control. A descriptive analysis was conducted to identify spatial and temporal patterns of cases.ResultsFrom 1995 to 2022, European France reported 117 locally acquired malaria cases, mostly due to <i>Plasmodium falciparum</i> (88%) and reported in Île-de-France (54%), Paris Region. Cases were classified as Odyssean malaria (n = 51), induced malaria (n = 36), cryptic malaria (n = 27) and introduced malaria (n = 3). Among the 117 patients, 102 (93%) were hospitalised, 24 (22%) had severe malaria and seven (7%) died.ConclusionLocally acquired malaria remains infrequent in European France, with four reported cases per year since 1995. However, with the recent increasing trend in Odyssean malaria and climate change, the risk of re-emergence in non-endemic countries should be monitored, particularly in areas with autochthonous competent vectors. The vital risk of delayed diagnosis should make physicians consider locally acquired malaria in all patients with unexplained fever, especially when thrombocytopenia is present, even without travel history.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 41","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing trends in hepatitis E hospitalisations in Spain, 1997 to 2019.","authors":"María Guerrero-Vadillo, Marina Peñuelas, Rocío Carmona, Inmaculada León-Gómez, Carmen Varela","doi":"10.2807/1560-7917.ES.2024.29.43.2400118","DOIUrl":"10.2807/1560-7917.ES.2024.29.43.2400118","url":null,"abstract":"<p><p>BackgroundHepatitis E, a viral hepatitis caused mainly by the ingestion of raw or undercooked food, is not a notifiable disease in Spain.AimTo analyse the temporal trends, epidemiological characteristics and factors associated with severe disease from hepatitis E hospitalisations in Spain from 1997 to 2019.MethodsHospitalisation records were obtained from the Spanish National Hospital Discharge Database. Temporal trends and seasonality were analysed by Poisson regression in years 1997-2015 and 2016-19, given changes in hospital discharge databases. Multivariate logistic regression was used to identify factors associated with severe disease.ResultsHepatitis E hospitalisation incidence increased from 0.22 cases per 1,000,000 inhabitants in 1997 to a maximum of 2.95 in 2018. Seasonality was observed during 2016-19 period, with more cases in the second and third quarters of the year. The incidence was higher in men vs women, and in the population aged over 40 years. Factors independently associated with death were age ≥ 50 years (adjusted odds ratio (aOR): 2.43), chronic liver disease (aOR: 4.29), HIV infection (aOR: 3.00) and hepatitis B/C (aOR: 2.11).ConclusionsHepatitis E hospitalisations have increased in Spain in recent years, being more severe in cases with older age, chronic hepatic diseases and HIV infection. A greater incidence in men over 40 years and a possible seasonality were observed. Further studies are needed to assess the seasonality, geographical distribution and impact of the disease to guide public health actions for prevention and control.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 43","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11513759/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142497705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attribution of invasive group A streptococcal infections (iGAS) to predisposing viral infections, the Netherlands, 2010 to 2023.","authors":"Brechje de Gier, Jan van de Kassteele, Liselotte van Asten, Annelot F Schoffelen, Mariette Hooiveld, Margreet Jm Te Wierik, Nina M van Sorge, Hester E de Melker","doi":"10.2807/1560-7917.ES.2024.29.40.2300739","DOIUrl":"10.2807/1560-7917.ES.2024.29.40.2300739","url":null,"abstract":"<p><p>BackgroundAfter most COVID-19 pandemic control measures were lifted in 2022, many infectious diseases re-emerged. An increase in invasive group A streptococcal (iGAS) infections among adults and young children was reported by several countries. Viral infections including influenza and varicella, known risk factors for iGAS infection, also increased.AimTo estimate the proportion of GAS skin and soft tissue infections (SSTI) and pneumonia/sepsis in children (≤ 5 years) attributable to varicella, and the proportion of GAS pneumonia/sepsis in children and adults attributable to potentially predisposing respiratory viruses influenza A and B, RSV, hMPV and SARS-CoV-2 in the Netherlands.MethodsWe performed time series regression using weekly data on respiratory viruses, varicella and non-invasive GAS infections and GAS isolates cultured from blood, lower airways, skin, pus and wounds, from January 2010 to March 2023.ResultsIn 2010-19, 50% (95% CI: 36-64) of GAS SSTI in children were attributable to varicella. Between January 2022 and March 2023, 34% (95% CI: 24-43) of GAS SSTI cases were attributable to varicella. Of iGAS pneumonia/sepsis between January 2022 and March 2023, 34% (95% CI: 20-49) and 25% (95% CI: 18-32) was attributable to respiratory virus infections in children and adults, respectively, with the largest contributor (17%) being influenza A.ConclusionsPredisposing viral infections likely contributed to, but cannot fully explain, the observed iGAS increase among children and adults in 2022-23 in the Netherlands. Public health measures to control viral infections, such as vaccination against varicella or influenza, might reduce the iGAS disease burden.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 40","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11451131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced laboratory surveillance of respiratory infection disclosed the rapid rise of enterovirus D68 cases, northern Italy, August to September 2024.","authors":"Elena Pariani, Antonio Piralla, Laura Pellegrinelli, Federica Giardina, Vincenzo Navobi Porrello, Greta Romano, Cristina Galli, Laura Sandri, Guglielmo Ferrari, Sandro Binda, Luigi Vezzosi, Gabriele Del Castillo, Sabrina Buoro, Danilo Cereda, Fausto Baldanti","doi":"10.2807/1560-7917.ES.2024.29.41.2400645","DOIUrl":"10.2807/1560-7917.ES.2024.29.41.2400645","url":null,"abstract":"<p><p>We report a considerable increase in enterovirus D68 (EV-D68) cases since July 2024, culminating in an ongoing outbreak of acute respiratory infections in northern Italy, accounting for nearly 90% of all enterovirus infections. The outbreak was identified by community- and hospital-based surveillance systems, detecting EV-D68 in individuals with mild-to-severe respiratory infections. These strains belonged to B3 and a divergent A2 lineage. An increase in adult cases was observed. Enhanced surveillance and molecular characterisation of EV-D68 across Europe are needed.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"29 41","pages":""},"PeriodicalIF":9.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142399845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}