Eurosurveillance最新文献

{"title":"Emergence of <i>Salmonella enterica</i> carrying <i>bla</i> _OXA-181 carbapenemase gene, Italy, 2021 to 2024.","authors":"Luca Bolzoni, Erika Scaltriti, Chiara Bracchi, Sara Angelone, Ilaria Menozzi, Roberta Taddei, Patricia Alba, Virginia Carfora, Elena Lavinia Diaconu, Marina Morganti, Alessandra Dodi, Melissa Berni, Laura Manni, Massimiliano Vinci, Martina Tambassi, Laura Mazzera, Irene Venturelli, Simone Ambretti, Antonio Battisti, Stefano Pongolini","doi":"10.2807/1560-7917.ES.2025.30.13.2500175","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2500175","url":null,"abstract":"<p><p>Between 2021 and 2024, we detected carbapenemase gene <i>blaOXA-181</i> in 16 of 11,398 <i>Salmonella enterica</i> (SE) isolates: 10 SE 1,4,[5],12:i:-, three Bovismorbificans, two London and one Rissen from pigs, humans, pork meat and wild roe deer. The gene was first detected in pig isolates, later in humans, suggesting zoonotic transmission. Phylogenetic analysis indicated that horizontal transfer, mainly through plasmids, contributed to the spread. These findings highlight a possible emerging public health threat and the importance of One Health surveillance.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying hotspots and risk factors for tick-borne encephalitis virus emergence at its range margins to guide interventions, Great Britain.","authors":"Richard Mj Hassall, Maya Holding, Jolyon M Medlock, Festus A Asaaga, Sophie O Vanwambeke, Roger Hewson, Bethan V Purse","doi":"10.2807/1560-7917.ES.2025.30.13.2400441","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2400441","url":null,"abstract":"<p><p>BackgroundTick-borne encephalitis virus (TBEV) is expanding its range in Europe, with increasing human cases reported. Since the first detection of TBEV in ticks in the United Kingdom in 2019, one possible, two probable and two confirmed autochthonous cases in humans have been reported.AimWe aimed to understand the environmental and ecological factors limiting TBEV foci at their range edge and predict suitable areas for TBEV establishment across Great Britain (GB) by modelling patterns of exposure to TBEV in deer.MethodsWe developed spatial risk models for TBEV by integrating data between 2018 and 2021 on antibodies against tick-borne flavivirus in fallow, muntjac, red and roe deer with data on potential risk factors, including climate, land use, forest connectivity and distributions of bank voles and yellow-necked mice. We overlayed modelled suitability for TBEV exposure across GB with estimations on number of visitors to predict areas of high human exposure risk.ResultsModels for fallow, muntjac and roe deer performed well in independent validation (Boyce index > 0.92). Probable exposure to TBEV was more likely to occur in sites with a greater percentage cover of coniferous woodland, with multiple deer species, higher winter temperatures and rates of spring warming.ConclusionThe resulting TBEV suitability maps can be used by public health bodies in GB to tailor surveillance and identify probable high-risk areas for human exposure to guide awareness raising and vaccination policy. Combining animal surveillance and iterative spatial risk modelling can enhance preparedness in areas of tick-borne disease emergence.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969960/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of integrated genomic surveillance by local public health authorities: Recommendations based on a mixed-methods study of current adoption, applications and success factors, Germany, 2023.","authors":"Anna Bludau, Alexander Jack, Nicole Fischer, Johannes Dreesman, Christian Drosten, Richard Egelkamp, Lutz Ehlkes, Fabian Feil, Adam Grundhoff, Hajo Grundmann, Pascal Kreuzer, Masyar Monazahian, Inga Overesch, Daniel Schmitt, Markus Tröger, Alexandra von Reiswitz, Jonas Weber, Alexander Dilthey, Claudia Hornberg, Sandra Reuter, Simone Scheithauer","doi":"10.2807/1560-7917.ES.2025.30.13.2400508","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2400508","url":null,"abstract":"<p><p>BackgroundIntegrated genomic surveillance (IGS), i.e. the integrated analysis of pathogen whole genome sequencing and classical epidemiological data, can contribute substantially to the disease surveillance and infection prevention activities of local public health authorities (LPHAs).AimOur aim was to characterise how LPHAs use IGS, and factors required or important for their implementation, in the context of the German public health system.MethodsWe employed a mixed-methods design combining a quantitative survey of 60 LPHAs in three German states with five qualitative case studies based on LPHAs in four German localities and one state-level public health authority.ResultsApproximately half of LPHAs reported adoption of IGS; applications included outbreak analysis (n = 25), targeting and evaluation of infection control measures (n = 25 and n = 18, respectively) and characterisation of pathogen transmission chains (n = 25). Factors identified as required or important for the implementation of IGS in LPHAs included fast sample-to-result turnaround times, organisational data interpretation capabilities and clearly defined surveillance sampling strategies. Based on the case studies in which the adoption of IGS was successful, we formulate recommendations for implementing IGS at the level of LPHAs, including establishment of dedicated IGS analysis teams within LPHAs, use of user-friendly digital solutions (e.g. browser-based dashboards) for data exchange and analysis, and implementation of IGS in collaboration with local academic institutions.ConclusionOur analysis paves the way for increasing the implementation of IGS by LPHAs in Germany and other countries with similarly structured public health systems.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fulminant infective endocarditis with toxin-negative <i>Corynebacterium diphtheriae</i> in people with substance use experiencing homelessness, England, 2024 to 2025.","authors":"Tara Patel, Tasnim Anwar, Eleni Mavrogiorgou, Natasa Utjesanovic, Anna Aryee, David J Litt, Joshua C D'Aeth, Christopher Primus, Satya Das, Nikolaos Karogiannis, Karthik Paranthaman, Gayatri Amirthalingam, Rebecca Cordery","doi":"10.2807/1560-7917.ES.2025.30.13.2500148","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2500148","url":null,"abstract":"<p><p>Between July 2024 and January 2025, five male patients in their early 20s to early 50s were confirmed with infective endocarditis associated with non-toxigenic <i>Corynebacterium diphtheriae</i> in England. Three were known to have experienced homelessness. All five used non-intravenous recreational drugs. Disease progression was rapid, four patients required surgical intervention, one died. Whole-genome sequencing and multilocus sequence type (MLST) analysis identified four individuals as ST559. Clinicians and substance use services have been alerted and enhanced surveillance implemented. A prevalence study is planned.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for antimicrobial stewardship and reduced antimicrobial resistance in the Mid-West of Ireland, 2012 to 2023: findings from a One Health study.","authors":"James Powell, Santosh Sharma, Alan Johnson, Siobhan Barrett, Caroline Garvan, Nuala H O'Connell, Colum P Dunne","doi":"10.2807/1560-7917.ES.2025.30.13.2400512","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.2400512","url":null,"abstract":"<p><p>Background<i>Escherichia coli</i>, a pathogen commonly infecting humans and bovines, is a prime sentinel indicator and predictor for antimicrobial resistance (AMR). Tracking epidemiological trends of AMR is essential to address this global One Health threat.AimTo perform a comprehensive retrospective epidemiological analysis of AMR trends in <i>E. coli</i> isolated from human urine and blood and bovine specimens, and compare with antimicrobial consumption or sales data for humans.MethodsAll <i>E. coli</i> isolates with susceptibility results from human urine (n = 122,419), blood (n = 2,373) and bovine specimens (n = 585) from 2012-23 in the Mid-West of Ireland were analysed. The resistance trends of nine commonly used antimicrobials were compared with their consumption by humans or sales in community and hospital settings.ResultsOver the 12-year period, resistance against common antimicrobials was lowest among the bovine isolates (range: 2-44%). Human urine isolates showed lower resistance (5-59%) than bloodstream isolates (12-69%). There was a downward trend in resistance to all antimicrobials between 2012 and 2023 in the human isolates (p < 0.001), except for piperacillin/tazobactam where resistance increased, in each case correlating with antimicrobial usage. Bovine isolates demonstrated reduced resistance to co-amoxiclav (p = 0.001), with no trend observed for other antimicrobials.ConclusionOur data showed reduced resistance to many antimicrobials for <i>E. coli</i> from human and bovine populations in our region. Increased use of 'preferred' antimicrobials in humans and reduced use of those 'to be avoided' was observed. The findings indicate the emerging effectiveness of AMR strategies and highlight the value of One Health AMR.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confirm your subscription to continue receiving our Table of contents.","authors":"","doi":"10.2807/1560-7917.ES.2025.30.13.250403m","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.250403m","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum for Euro Surveill. 2025;30(5).","authors":"","doi":"10.2807/1560-7917.ES.2025.30.13.250403e","DOIUrl":"10.2807/1560-7917.ES.2025.30.13.250403e","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 13","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's response: Viral load decline time offers theoretical insight rather than practical value.","authors":"Jakob Jonnerby, Ajit Lalvani","doi":"10.2807/1560-7917.ES.2025.30.9.2500155","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2500155","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health inequalities in incidence of bacteraemias: a national surveillance and data linkage study, England, 2018 to 2022.","authors":"Andrea Mazzella, Zahin Amin-Chowdhury, Amelia Andrews, Andre Charlett, Colin S Brown, Russell Hope, Dimple Chudasama","doi":"10.2807/1560-7917.ES.2025.30.9.2400312","DOIUrl":"10.2807/1560-7917.ES.2025.30.9.2400312","url":null,"abstract":"<p><p>BackgroundHealth inequalities exist globally, but limited data exist on this topic for bacteraemia.AimIn this study we investigated health inequalities surrounding bacteraemia in England, to identify high-risk population groups and areas of intervention.MethodsWe retrospectively analysed English surveillance data between 2018 and 2022 for <i>Escherichia coli</i>, <i>Klebsiella</i> species, <i>Pseudomonas aeruginosa</i>, and both meticillin-sensitive and resistant <i>Staphylococcus aureus</i> (MSSA, MRSA) bacteraemia. Crude incidence rates stratified by index of multiple deprivation and ethnic groups were calculated; age-adjusted rate ratios were estimated using negative binomial regression models.ResultsWe identified 342,787 bacteraemia cases. Across all pathogens, as the level of deprivation rose, so did the age-adjusted bacteraemia incidence rate ratio. Compared with residents of the 20% least deprived areas of England, residents of the 20% most deprived areas had a 2.68-fold increased bacteraemia rate for MRSA (95% CI: 2.29-3.13) and 1.95-fold for <i>E. coli</i> (95% CI: 1.84-2.05), and 15% higher odds of dying within 30 days of any bacteraemia (95% CI: 1.13-1.19). After age adjustment, the incidence of all bacteraemia was higher in the Asian and Black groups compared with the White group: for MRSA, 79% higher in the Asian (95% CI: 1.51-2.10) and 59% higher in the Black (95% CI: 1.29-1.95) groups. The exception was MSSA, whose incidence was highest in the White group.ConclusionDisproportionately higher age-adjusted incidence of bacteraemia occurred in deprived areas and ethnic minorities. These disparities are likely multifactorial, possibly including socioeconomic, cultural, and systemic risk factors and different burden of comorbidities. Better understanding these factors can enable targeted interventions.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 9","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Job vacancy at the European Centre for Disease Prevention and Control (ECDC).","authors":"","doi":"10.2807/1560-7917.ES.2025.30.12.25032705","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.12.25032705","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 12","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11951415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}