Eurosurveillance最新文献

{"title":"Genomic insights into the re-emergence of chikungunya virus on Réunion Island, France, 2024 to 2025.","authors":"Etienne Frumence, Géraldine Piorkowski, Nicolas Traversier, Rayane Amaral, Muriel Vincent, Ambroise Mercier, Nazli Ayhan, Laurent Souply, Laura Pezzi, Clément Lier, Gilda Grard, Guillaume André Durand, Xavier Deparis, Fabian Thouillot, Xavier de Lamballerie, Raphaelle Klitting, Marie-Christine Jaffar-Bandjee","doi":"10.2807/1560-7917.ES.2025.30.22.2500344","DOIUrl":"10.2807/1560-7917.ES.2025.30.22.2500344","url":null,"abstract":"<p><p>Chikungunya virus re-emerged on Réunion Island in August 2024, 18 years after a first major outbreak. Analysis of 173 genomes from the current epidemic reveals a monophyletic clade with mutations linked to adaptation to <i>Aedes albopictus</i> mosquitoes, including E1-A226V. Bayesian inference suggests only brief cryptic circulation before detection. The same lineage was also detected on Mayotte Island in March 2025. Continued spread and confirmed travel-related cases in mainland France and globally highlight the risk of wider regional and international dissemination.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 22","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143119/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond patient contact: combined short- and long read sequencing reveals continuous occurrence of genomically related carbapenemase-producing Enterobacterales and plasmid mobility in a hospital, Germany, 2018 to 2021.","authors":"Nora Helke Leder, Monika Cristofolini, Sandra Ehrenberg, Mara Lohde, Christian Brandt, Mathias W Pletz, Frank Kipp, Claudia Stein","doi":"10.2807/1560-7917.ES.2025.30.23.2400590","DOIUrl":"10.2807/1560-7917.ES.2025.30.23.2400590","url":null,"abstract":"<p><p>BACKGROUNDCarbapenemase-producing Enterobacterales (CPE) frequently cause nosocomial outbreaks. To investigate these, tracing focused on patients with related CPE strains and spatiotemporal contact (e.g. contact with each other in a room or on a ward during overlapping periods) has limitations. Moreover, as widely available molecular typing methods cannot detect plasmid-related transmissions, carbapenemase gene transfer across enteric bacteria through plasmids in hospitals remains poorly understood.AIMBecause whole-genome sequencing (WGS), particularly long-read sequencing, can offer insights into bacterial relationships both at core-genome and plasmid levels, we tested its utility, using VIM-CPE as example, to investigate plasmid and CPE spread in a hospital beyond outbreaks.METHODSWe included inpatient episodes from 2018 to 2021 involving <i>bla</i> _VIM-bearing CPE isolates. Short- and long-read WGS data were combined with patient movement information to identify genomically related hospital-acquired VIM-CPE and putative transmission routes.RESULTSAmong 43 included inpatient episodes, 27 isolates were hospital-acquired, with 23 genomically related based on core-genome or plasmid analyses. For 14 of these 23 isolates, patient movement data supported suspected transmission events. Plasmid and core-genome level analyses revealed that most transmission events did not temporally concur, occurring over up to 33 months. Thus, conventional infection tracing methods focusing on concurrent spatiotemporal contact missed a substantial proportion of transmission events.CONCLUSIONWith our findings, we advocate for broader epidemiological investigations of temporal connections if genomic data suggest relatedness. We emphasise considering plasmid transfer alongside analyses of core-genome relatedness of bacteria beyond patient contact events to study CPE and resistance spread, and guide infection control strategies.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 23","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of cell phone data to correct Île-de-France population estimates and SARS-CoV-2 incidence, July to September, 2021: a proof-of-concept exercise.","authors":"Arnaud Tarantola, Mohamed Hamidouche","doi":"10.2807/1560-7917.ES.2025.30.22.2400530","DOIUrl":"10.2807/1560-7917.ES.2025.30.22.2400530","url":null,"abstract":"<p><p>BackgroundDuring the COVID-19 pandemic, Santé publique France (SpF) published incidence (SpF<i>i</i>) rates based on census denominators. Denominators using cell phone connection (CPC) data can better reflect the population present and seasonal mobilities.AimGiven uncertainties regarding the actual number of Île-de-France (IdF) residents present in IdF during summer 2021, we aimed to better approximate true incidence rates from positive SARS-CoV-2 tests in IdF using CPC-derived population denominators.MethodThis longitudinal study used the daily number of positive tests (PCR and Ag) on IdF residents in IdF as the numerator and the estimated resident population present in IdF at midnight as the denominator. We computed the mean corrected incidence rate (MCIR) per moving week between 4 July and 9 September 2021.ResultsThe MCIR showed higher incidence rates than initially estimated, especially during August when residents had left IdF for the holidays. Incidence rates reached a peak on 16 August when the SpF<i>i</i> rate per moving week was 200.9 per 100,000 compared with 315.6 per 100,000 with the MCIR, representing a 57% increase.ConclusionUsing local SARS-CoV-2 testing data and real-time population denominators, we showed that indicators using non-geographically referenced test results and fixed population denominators that ignore seasonal mobility can significantly underestimate incidence rates in IdF. New data sources using CPC data provide the opportunity to calculate more accurate and dynamic incidence rates and to map epidemics more precisely and in real time.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 22","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author's correction for Euro Surveill. 2025;30(22).","authors":"","doi":"10.2807/1560-7917.ES.2025.30.23.250612c","DOIUrl":"10.2807/1560-7917.ES.2025.30.23.250612c","url":null,"abstract":"","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 23","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164282/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological changes in <i>Chlamydia pneumoniae</i> molecular detections before, during and after the COVID-19 pandemic in 27 European sites and Taiwan, 2018 to 2023.","authors":"Florian Tagini, Søren Anker Uldum, Carla Berengua, Branislav Ivan, Riccarda Capaul, Sophie Edouard, Adrien Fischer, Jacky Flipse, Diego García Martínez de Artola, Daniel Goldenberger, Edou Heddema, Mirjam Hermans, Frank Imkamp, Darja Keše, Clara Lejarraga, Reto Lienhard, Carola Maffioli, Veerle Matheeussen, Patrick M Meyer Sauteur, Irena Mitrovic, Onya Opota, Christina Orasch, Pavel Drevinek, Olivia Peuchant, Liu Po-Yu, Mirja Puolakkainen, Melissa Remy, Khoa Td Thai, Nadia Wohlwend, Gilbert Greub","doi":"10.2807/1560-7917.ES.2025.30.23.2400682","DOIUrl":"10.2807/1560-7917.ES.2025.30.23.2400682","url":null,"abstract":"<p><p>BackgroundDuring the COVID-19 pandemic, non-pharmaceutical interventions (NPIs) such as social distancing, lockdowns and enhanced hygiene led to a decrease in respiratory pathogens. However, as NPIs were relaxed, a resurgence in several respiratory pathogens was observed including one local <i>Chlamydia pneumoniae</i> outbreak in Switzerland, prompting the need for a better understanding of <i>C. pneumoniae</i> epidemiology.AimTo assess temporal and geographical variations in <i>C. pneumoniae</i> detection before, during and after the COVID-19 pandemic.MethodsData on <i>C. pneumoniae</i> PCR detection ratios (number of positive tests/ total number of tests) across pre-pandemic (2018-2019), pandemic (2020-2022) and post-pandemic (2023) periods were collected via a global survey disseminated through various professional networks.Results<i>C. pneumoniae</i> detection ratios were analysed across 28 sites (27 in Europe, one in Taiwan) in 2023 (Dataset A, n = 172,223 tests) and 20 sites from 2018 to 2023 (Dataset B, n = 693,106 tests). Twenty-seven sites were laboratories (hospital or clinical) and one a surveillance system (Denmark). A significant decrease in detection ratios was observed during the pandemic period (from 1.05% to 0.23%, p < 0.001). In 2023, detection ratios increased to 0.28% (p < 0.002). Notable regional variations were found, with statistically significant increases in detection ratios at six sites located in Switzerland and Slovenia, where ratios ranged from 0.52% to 3.25%.DiscussionThe study highlights how NPIs influenced <i>C. pneumoniae</i> epidemiology, with reduced detection during the pandemic and partial resurgence afterwards. Regional variations suggest differing NPI impacts and underscore the need for continued surveillance.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 23","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular detection of <i>Toxoplasma gondii</i> in ready-to-eat salad mixes: multi-country survey using a validated and harmonised standard operating procedure, Europe, 2021 to 2022.","authors":"Rafael Calero-Bernal, Martha Betson, Iva Slana, Barbora Bartosova, Gianluca Marucci, Alessia Possenti, Gema Álvarez-García, Nadja Bier, Anne Mayer-Scholl, Rebecca P Berg, Umer Chaudhry, Nadia M López-Ureña, Weronika Piotrowska, Jacek Sroka, Gro S Johannessen, Rebecca Davidson, Filip Dámek, Radu Blaga, Sandra Thoumire, Barbora Zalewská, Helga C Waap, Pikka Jokelainen, Marco Lalle","doi":"10.2807/1560-7917.ES.2025.30.22.2400594","DOIUrl":"10.2807/1560-7917.ES.2025.30.22.2400594","url":null,"abstract":"<p><p>BackgroundMost <i>Toxoplasma gondii</i> infections in humans are considered foodborne, but the relative importance of the various routes of infection is largely unknown. Consumption of green produce contaminated with <i>T. gondii</i> oocysts has been identified as a possible source.AimWe aimed to estimate the occurrence and prevalence of <i>T. gondii</i> oocysts in commercially available ready-to-eat (RTE) salad mixes in 10 European countries.MethodsA real-time PCR-based method for oocyst detection was developed and optimised by two laboratories and validated in an interlaboratory test. This detection method and a harmonised sampling strategy were applied in a multi-country study. Multivariable logistic regression was used to investigate risk factors for oocyst contamination of RTE salad.ResultsThe real-time PCR method had a detection limit of 10 oocysts per 30 g of salad. We collected 3,329 RTE salad samples (baby leaf and cut leaf mixes) from October 2021 to September 2022. The prevalence of <i>T. gondii</i> oocyst contamination was 4.1% (95% confidence interval (CI): 3.4-4.8%; n = 3,293). In multivariable regression analysis, winter season, sampling and packaging of salad in Northern Europe and production of salad in Western Europe were associated with detection of <i>T. gondii</i>, with no statistically significant differences between salad types.ConclusionWe estimated the prevalence of <i>T. gondii</i> oocysts in RTE leafy green salads using a validated and standardised procedure to assess the potential risk for human infection; highlighting the need to address this risk at each critical point of the salad production chain.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 22","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Swine influenza virus surveillance programme pilot to assess the risk for animal and public health, the Netherlands, 2022 to 2023.","authors":"Erhard van der Vries, Evelien A Germeraad, Annelies Kroneman, Lucía Dieste-Pérez, Dirk Eggink, Eveline Willems, Alexander Mp Byrne, Nicola Lewis, Manon Houben, Ron Fouchier, Adam Meijer, Joke van der Giessen","doi":"10.2807/1560-7917.ES.2025.30.22.2400664","DOIUrl":"10.2807/1560-7917.ES.2025.30.22.2400664","url":null,"abstract":"<p><p>BackgroundSwine influenza has a considerable impact on pig populations and poses a pandemic threat to humans. However, little is known about the influenza A viruses circulating among pigs in the Netherlands.AimWe piloted a surveillance programme aimed at enabling swine influenza A virus (swIAV) surveillance in the Netherlands: investigated prevalence, genomic characteristics and recent evolution of circulating swIAV variants and compared them with relevant human and swine influenza viruses from the Netherlands and other European countries.MethodsWe collected and tested respiratory samples from pigs (2019-2023) for swIAV, characterised the viruses with molecular and virological methods and shared molecular data of swine and relevant human influenza A viruses in a national platform.ResultsWe detected swIAV throughout the year in 342 (42%) of 824 respiratory samples from 90 farms. Complete genome sequencing identified 73 H1N1, 51 H1N2 and one H3N2 viruses. Phylogenetic analyses identified viruses from each of the three H1 swine lineages (1A/B/C) and four subclades. Viruses from the 1A lineage clustered into three subgroups with distinct antigenic properties, which seemed descendent from separate introductions of human seasonal A(H1N1)pdm09 viruses. Phenotypically, no reduced susceptibility to existing antiviral drugs oseltamivir and zanamivir was found.ConclusionWe provided insights into swIAVs in pigs in the Netherlands, including antiviral susceptibility and antigenic differences. It highlighted occasional virus transmission between humans and pigs. Sharing swIAV data at a national level will be continued to reduce influenza burden in swine and support identification and characterisation of emerging swIAVs with zoonotic potential.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 22","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccine effectiveness in Europe and the birth cohort effect against influenza A(H1N1)pdm09: VEBIS primary care multicentre study, 2023/24.","authors":"Esther Kissling, Marine Maurel, Francisco Pozo, Gloria Pérez-Gimeno, Silke Buda, Noémie Sève, Lisa Domegan, Mariëtte Hooiveld, Beatrix Oroszi, Iván Martínez-Baz, Raquel Guiomar, Neus Latorre-Margalef, Ivan Mlinarić, Mihaela Lazar, Jaume Giménez Duran, Ralf Dürrwald, Vincent Enouf, Adele McKenna, Marit de Lange, Gergő Túri, Camino Trobajo-Sanmartín, Verónica Gomez, Tove Samuelsson Hagey, Vesna Višekruna Vučina, Maria Carmen Cherciu, Miriam García Vazquez, Annika Erdwiens, Shirley Masse, Charlene Bennett, Adam Meijer, Katalin Kristóf, Jesús Castilla, Ana Paula Rodrigues, Sanja Kurečić Filipović, Alina Elena Ivanciuc, Sabrina Bacci, Marlena Kaczmarek","doi":"10.2807/1560-7917.ES.2025.30.23.2500011","DOIUrl":"10.2807/1560-7917.ES.2025.30.23.2500011","url":null,"abstract":"<p><p>IntroductionInfluenza A(H1N1)pdm09, A(H3N2) and B/Victoria viruses circulated in Europe in 2023/24, with A(H1N1)pdm09 dominance. First influenza infections in childhood may lead to different vaccine effectiveness (VE) in subsequent years.AimThe VEBIS primary care network estimated influenza VE in Europe using a multicentre test-negative study.MethodsPrimary care practitioners collected information and specimens from patients consulting with acute respiratory infection. We estimated VE against influenza (sub)type and clade, by age group and by year of age for A(H1N1)pdm09, using logistic regression.ResultsWe included 29,958 patients, with 3,054, 1,053 and 311 influenza A(H1N1)pdm09, A(H3N2) and B cases, respectively. All-age VE against influenza A(H1N1)pdm09 was 52% (95% CI: 44-59). By year of age, VE was 27% (95% CI: -2 to 47) at 44 years with peaks at 72% (95% CI: 52-84) and 54% (95% CI: 41-64) among children and those 65 years and older, respectively. All-age A(H1N1)pdm09 VE against clade 5a.2a was 41% (95% CI: 24-54) and -11% (95% CI: -69 to 26) against clade 5a.2a.1. The A(H3N2) VE was 35% (95% CI: 20-48) among all ages and ranged between 34% and 40% by age group. All-age VE against clade 2a.3a.1 was 38% (95% CI: 1-62). All-age VE against B/Victoria was 83% (95% CI: 65-94), ranging between 70 and 92% by age group.DiscussionThe 2023/24 VEBIS primary care VE against medically attended symptomatic influenza infection was high against influenza B/Victoria, but lower against influenza A(H1N1)pdm09 and A(H3N2). Clade- and age-specific effects may have played a role in the lower A(H1N1)pdm09 VE.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 23","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12164280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of healthcare services preceding HIV diagnosis - missed opportunities for earlier diagnosis, Finland, 1996 to 2019.","authors":"Sanna Isosomppi, Mikaela Mutru, Jukka Ollgren, Henrikki Brummer-Korvenkontio, Kirsi Liitsola, Jussi Sutinen, Inka Aho, Pia Kivelä","doi":"10.2807/1560-7917.ES.2025.30.18.2400610","DOIUrl":"https://doi.org/10.2807/1560-7917.ES.2025.30.18.2400610","url":null,"abstract":"<p><p>BackgroundHIV testing based on indicator conditions is recommended to diagnose HIV earlier.AimOur aim was to assess opportunities for earlier diagnosis of HIV.MethodThis is a retrospective study on people living with HIV (PLWH) included in the national HIV register. We collected data on public primary outpatient healthcare (PHC) (2011-2019), secondary and tertiary outpatient healthcare (STHC), and all inpatient care (1996-2019) from the Care Register for Health Care from the presumed acquisition, estimated by CD4+ T-cell count at diagnosis, until the diagnosis of HIV.ResultsOf 907 PLWH diagnosed between 2011 and 2019, 522 (58%) had ≥ 1 healthcare contact at any level between HIV acquisition and > 30 days before diagnosis. At least one European Centre for Disease Prevention and Control (ECDC) indicator condition was recorded for 119 (23% of 522), and 112 (21%) were born in a high-prevalence country. In total, 384 of 907 (42%) had visited a PHC physician, and 58% of those with CD4+ T-cell count < 200 cells/μL at diagnosis. Of 2,082 PLWH diagnosed between 1996 and 2019, 869 (42%) had STHC outpatient contacts > 30 days before diagnosis, 18% with ≥ 1 ECDC indicator condition, and 367 (18%) had been hospitalised, 20% with ≥ 1 ECDC indicator condition. The most common ECDC indicator conditions > 30 days before diagnosis at all levels of healthcare were pneumonia, sexually transmitted infections, unexplained fever, herpes zoster, pregnancy and lymphadenopathy.ConclusionWe recommend enhancing indicator condition-based HIV testing by all healthcare providers, particularly for gonorrhoea, syphilis and, for persons younger than 50 years, also herpes zoster and lymphadenopathy.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 18","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human infections with Eurasian avian-like swine influenza virus detected by coincidence via routine respiratory surveillance systems, the Netherlands, 2020 to 2023.","authors":"Dirk Eggink, Annelies Kroneman, Jozef Dingemans, Gabriel Goderski, Sharon van den Brink, Mariam Bagheri, Pascal Lexmond, Mark Pronk, Erhard van der Vries, Evelien Germeraad, Diederik Brandwagt, Manon Houben, Mariëtte van Hooiveld, Joke van der Giessen, Rianne van Gageldonk-Lafeber, Ron Fouchier, Adam Meijer","doi":"10.2807/1560-7917.ES.2025.30.19.2400662","DOIUrl":"10.2807/1560-7917.ES.2025.30.19.2400662","url":null,"abstract":"<p><p>BackgroundZoonotic influenza, including infections with avian and swine influenza A viruses (swIAV), is a notifiable disease in the Netherlands. Human cases infected with swIAV have previously been rarely detected in the Netherlands.AimWe aimed to describe detection and characterisation of Eurasian avian-like swIAV infections in humans in the Netherlands 2020-2023.MethodsThe Dutch National Influenza Center coordinates different activities to monitor respiratory infections and circulating human influenza viruses. This monitoring includes sentinel surveillance in general practitioner practices, community participatory surveillance and characterisation of influenza viruses received from diagnostic laboratories. A subset of the specimens positive for influenza A virus from the monitoring activities are sent for further characterisation. We characterised swIAV from human patients using whole genome sequencing, tested the viruses for antiviral susceptibility and in haemagglutination inhibition assays for antigenic characterisation and compared them with previous detections from humans and pigs.ResultsAvian-like swine influenza virus was detected in three persons presenting with mild respiratory symptoms, and all recovered fully. Only one patient had close contact with pigs shortly before the start of symptoms. Sequence analyses of the viruses showed clustering with swAIV from pigs in a recently initiated surveillance system on pig farms.ConclusionsThese human cases show that swIAV viruses with zoonotic potential are enzootic in the Netherlands. Finding them by coincidence suggests human infections might occur more frequently than noticed.</p>","PeriodicalId":12161,"journal":{"name":"Eurosurveillance","volume":"30 19","pages":""},"PeriodicalIF":9.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}