肺炎克雷伯菌花叶耐药（OXA-48）和毒力（有氧肌动蛋白）质粒的跨界传播：欧洲抗微生物药物耐药性基因监测网络调查，欧洲，2019年2月至2024年10月

IF 9.9 2区医学 Q1 INFECTIOUS DISEASES

Eurosurveillance Pub Date : 2025-07-01 DOI:10.2807/1560-7917.ES.2025.30.27.2500439

Marius Linkevicius, Erik Alm, Louise Roer, Olov Svartström, Maria Dada-Olorunwa, Kati Räisänen, Felix Reichert, Sophie Möller, Christina Clarke, Martin Cormican, Baiba Niedre-Otomere, Reinis Vangravs, Paulius Greičius, Olga Burduniuc, Maria Anton, Antoni P A Hendrickx, Sandra Witteveen, Vilhelm Müller, Daniel Palm, Diamantis Plachouras, Dominique L Monnet, Henrik Hasman, Anke Kohlenberg

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引用次数: 0

摘要

对欧洲抗微生物药物耐药性基因监测网络（EURGen-Net）的调查发现，2019-2024年期间，来自8个欧盟国家的492株肺炎克雷伯菌分离株具有相同的mosaic IncHI1B（pNDM-MAR）耐药性（OXA-48）和毒力（aerobactin）质粒。不同肺炎克雷伯菌序列类型（st）的参与、多次引入以及随后在两个国家携带质粒的三种st （ST147、ST392、ST45）的大规模克隆暴发表明，这种质粒进一步传播的风险很高，并且难以治疗的肺炎克雷伯菌感染可能会上升。

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Cross-border spread of a mosaic resistance (OXA-48) and virulence (aerobactin) plasmid in Klebsiella pneumoniae: a European Antimicrobial Resistance Genes Surveillance Network investigation, Europe, February 2019 to October 2024.

An investigation of the European Antimicrobial Resistance Genes Surveillance Network (EURGen-Net) detected the same mosaic IncHI1B(pNDM-MAR) resistance (OXA-48) and virulence (aerobactin) plasmid in 492 Klebsiella pneumoniae isolates from eight European Union countries during 2019-2024. Involvement of various K. pneumoniae sequence types (STs), multiple introductions, followed by large clonal outbreaks of three STs (ST147, ST392, ST45) carrying the plasmid in two countries indicate a high risk for further spread of this plasmid and a potential for difficult-to-treat K. pneumoniae infections to rise.

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来源期刊

Eurosurveillance INFECTIOUS DISEASES-

CiteScore

32.70

自引率

2.10%

发文量

430

审稿时长

3-8 weeks

期刊介绍： Eurosurveillance is a European peer-reviewed journal focusing on the epidemiology, surveillance, prevention, and control of communicable diseases relevant to Europe.It is a weekly online journal, with 50 issues per year published on Thursdays. The journal includes short rapid communications, in-depth research articles, surveillance reports, reviews, and perspective papers. It excels in timely publication of authoritative papers on ongoing outbreaks or other public health events. Under special circumstances when current events need to be urgently communicated to readers for rapid public health action, e-alerts can be released outside of the regular publishing schedule. Additionally, topical compilations and special issues may be provided in PDF format.