Experimental and clinical psychopharmacology最新文献

{"title":"Pharmacokinetic assessment of JUUL2 18 mg/mL electronic nicotine delivery system in four flavors relative to cigarettes and a 5% (58 mg/mL) nicotine pod-based electronic nicotine delivery system among adult dual users.","authors":"Nicholas I Goldenson, Douglas R Oliveri, Qiwei Liang, Saul Shiffman","doi":"10.1037/pha0000873","DOIUrl":"https://doi.org/10.1037/pha0000873","url":null,"abstract":"<p><p>Assessing the nicotine pharmacokinetics of new electronic nicotine delivery system (ENDS) products can inform their abuse liability and public health effects. Nicotine delivery from JUUL2 ENDS products in four flavors (Virginia Tobacco, Polar Menthol, Autumn Tobacco, and Summer Menthol [18 mg/mL nicotine]) was compared to combustible cigarettes and NJOY Ace 5.0%, a pod-based ENDS authorized by Food and Drug Administration (classic tobacco and menthol flavors; 58 mg/mL), in two similarly designed but independent randomized crossover pharmacokinetics studies. All participants were adults who were daily cigarette smokers and concurrently used ENDS-dual users (Study 1, <i>N</i> = 44; Study 2, <i>N</i> = 30). Participants first used each product in a controlled use session (10 standardized 3-second puffs) and then a 5-min <i>ad libitum</i> use session. In both studies, when used by experienced ENDS users: (a) JUUL2 18 mg/mL products delivered statistically significantly lower peak levels of nicotine and exposed dual users to lower total levels of nicotine than combustible cigarettes; (b) nicotine delivery from use of JUUL2 18 mg/mL products was significantly lower than NJOY Ace 5.0% following controlled use, but more similar after <i>ad libitum</i> use; and (c) nicotine exposure did not significantly vary between tobacco- and menthol-flavored JUUL2 products. These results indicate that (a) JUUL2 18 mg/mL products expose users to significantly lower levels of nicotine than cigarettes, suggesting lower abuse liability; (b) abuse liability of JUUL2 18 mg/mL products is within the range of NJOY Ace 5%, an Food and Drug Administration-authorized pod-based ENDS; and (c) flavor did not significantly affect nicotine delivery from JUUL2 18 mg/mL products. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of behavioral economic demand in human abuse potential assessment: A review and recommendations for future testing.","authors":"Justin C Strickland, Derek D Reed, Mikhail N Koffarnus, Samuel F Acuff, Brett W Gelino, Madison E Graham, Brent A Kaplan, Alexandra Johansen, Zachary Pierce-Messick, Matthew L Banks, S Stevens Negus, David N Kearns, Dominic Chiapperino, Chad J Reissig, Neil B Varshneya, Steven R Hursh","doi":"10.1037/pha0000877","DOIUrl":"10.1037/pha0000877","url":null,"abstract":"<p><p>A key step in the regulatory evaluation of new chemical entities is the assessment of their abuse potential. Human abuse potential (HAP) studies provide insights into the likelihood that new chemical entities have the potential for intentional, nonmedical use and therefore should be considered for greater regulatory control. Behavioral economic demand methods are proposed as a complementary method to improve the resolution of abuse liability testing. These procedures are posited to provide scalar, rank-ordered comparisons of abuse potential that are comparable across drugs and to better model real-world contexts in which constraint and cost influence drug-taking potential. The current review considers the applicability of behavioral economic demand methods to HAP testing frameworks. We review existing studies that have applied procedures broadly consistent with HAP testing and integrated demand procedures to measure abuse potential and/or a drug reinforcement. Procedural details and the demand methods implemented are reviewed toward the goal of informing the methods for applying demand testing in the HAP study framework and the existing gaps in defining those methods. Ultimately, efforts to improve the sensitivity and resolution of assays to detect and differentiate abuse potential stand to improve public health by concentrating efforts on the adequate control of drugs that pose risk while minimizing the restrictions on those with a lower abuse potential to maximize their clinical utility. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13519940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of fluoxetine on the aversive effects of lysergic acid diethylamide.","authors":"Rachel Crupi, Kacie Jimenez, Nina Sanel, Will Shister, Magda Travaglia, Anthony L Riley","doi":"10.1037/pha0000876","DOIUrl":"https://doi.org/10.1037/pha0000876","url":null,"abstract":"<p><p>Serotonergic antidepressant history can reduce the subjective effects, including therapeutic efficacy, of a number of psychedelics. A related issue is the impact of traditional antidepressants with serotonergic action on the adverse effects of psychedelics. Becker et al. (2025) reported that adverse effects induced by lysergic acid diethylamide (LSD) were reduced by pretreatment with the selective serotonin reuptake inhibitor paroxetine, while \"good drug effects\" induced by LSD were not. The present studies examined if exposure to the selective serotonin reuptake inhibitor fluoxetine impacts the aversive effects of LSD as assessed in the taste avoidance procedure, a behavioral index of the aversive effects of drugs. After determining a dose of LSD inducing intermediate taste avoidance in male Sprague-Dawley rats (Experiment 1), a different set of subjects in Experiment 2 were exposed to fluoxetine (10 mg/kg) or vehicle every fourth day for a total of five injections prior to taste avoidance conditioning in which saccharin was followed by 50 ug/kg LSD or saline over six trials. Subjects were then assessed over extinction in which they were given saccharin alone. Although there was no overall impact of fluoxetine on LSD, consumption by a subset of subjects in the fluoxetine-LSD group that drank less than the group's mean did not overlap with consumption of subjects drinking less than the mean of the vehicle-LSD group, indicating an attenuating effect of fluoxetine. Future work should assess the generalization of such effects across different psychedelic classes and the neurobiological mediation of the effects with other combinations of antidepressants and psychedelics. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A theory-informed examination of biopsychosocial influences on transdermal alcohol concentration and next-day reports of alcohol-induced blackouts in young adults.","authors":"Veronica L Richards, Shannon D Glenn, Robert J Turrisi, Kimberly A Mallett, Sarah Ackerman, Carrie Wallace, Michelle R vanDellen, Michael A Russell","doi":"10.1037/pha0000875","DOIUrl":"10.1037/pha0000875","url":null,"abstract":"<p><p>Alcohol-induced blackouts (AIBs) are a common and serious consequence of drinking often associated with increased alcohol-related harms. Understanding factors that place individuals at increased odds of experiencing an AIB is critical to inform interventions aimed at reducing alcohol-related harms. The present study seeks to examine a theory-informed model of biopsychosocial factors that may increase a person's risk for experiencing AIBs over and above drinking. Young adults (<i>n</i> = 175, 52.6% female, 86.9% White, <i>M</i>_age = 20.8) with recent history of heavy drinking and AIBs wore transdermal alcohol concentration sensors and completed twice-daily surveys about previous-day alcohol use and AIBs over six weekends. Multilevel structural equation models were conducted to test for direct and indirect effects (through transdermal alcohol concentration) of social norms (descriptive and injunctive AIB norms, separately), psychological factors (impulsivity and sensation seeking), and family history of alcohol problems on AIB risk. One in three drinking days (<i>n</i> = 535, 33.8%) resulted in an AIB. Descriptive AIB norms (<i>OR</i> = 1.42, 95% CrI [1.06, 1.97]) and family history (<i>OR</i> = 1.41, 95% CrI [1.04, 1.92]) were uniquely associated with increased odds of experiencing AIBs. Psychological influences were not significantly associated with AIBs. No indirect effects were observed. In a theory-informed examination of biopsychosocial factors, higher descriptive norms and family history increased the odds of experiencing AIBs. Our findings highlight the potential value of future research examining interventions targeting misperceptions of peer AIB frequency. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148706049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further adaptation of cross-commodity purchase task methodology: The impact of preference rank on demand.","authors":"Sarah C Weinsztok, Derek D Reed, Michael Amlung","doi":"10.1037/pha0000872","DOIUrl":"10.1037/pha0000872","url":null,"abstract":"<p><p>A behavioral economic framework of alcohol use posits that alcohol use is a temporally extended pattern of behavior and occurs in contexts in which other response options are available. Hypothetical purchase tasks are based in behavioral economic theory and allow for researchers to pinpoint demand for commodities. An extension of purchase task methodology, cross-commodity tasks examine demand for a substance when two or more commodities are concurrently available. Recent research has extended these tasks to examine the impact of competing activities on alcohol demand. The present study extends this work by examining the extent to which rank-order preference for alternative activities would differentially impact demand for alcohol and serve as substitutes. Participants were crowdsourced via Prolific and completed a rank-order assessment of preference of activities and hobbies, an alcohol purchase task, and measures of suitability and rewarding value of alcohol-related activities. They responded to three separate cross-commodity tasks in which the highest, second-highest, or lowest preferred activity was presented at fixed low cost, while the price of alcohol increased. Results indicated that though rank preference did not impact substitutability of activities for alcohol, demand for alcohol was greater suppressed in the presence of high-preferred than low-preferred activities. Additionally, reported consumption of activities was greatest when the activities were highly preferred. Taken collectively, results highlight the utility of purchase task methodology and demand curve analyses in identifying alternative activities and the need for continued research exploring the functional reinforcing components of alternative activities to incorporate in interventions for hazardous alcohol use. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A further examination of the validity of assessing demand intensity using the Cigarette Purchase Task.","authors":"Katya A Nolder, Tyler G Erath, Michael J DeSarno, Elias M Klemperer, Stephen T Higgins","doi":"10.1037/pha0000874","DOIUrl":"10.1037/pha0000874","url":null,"abstract":"<p><p>The cigarette purchase task (CPT) is an efficient and safe method to simulate cigarette demand. In prior research, the CPT demand intensity index (estimated consumption if cigarettes were free) overestimated actual consumption. This study had three aims: (a) further examine concordance between demand intensity and actual consumption; (b) compare their relative sensitivity to individual differences in smoking risk; and (c) examine overestimation prevalence and predictors. Participants were adults who smoked daily with comorbid psychiatric disorders or socioeconomic disadvantage. Participants completed the CPT prior to receiving free usual-brand cigarettes for 7 days, with daily consumption recorded via interactive voice response. Aim 1 (<i>n</i> = 326): Demand intensity overestimated interactive voice response smoking by an average of 3.46 (standard error of the mean, 0.06) cigarettes smoked/day (<i>p</i> < .001). Aim 2 (<i>n</i> = 326): CPT and interactive voice response were concordant in discerning differences in smoking risk by opioid use disorder (<i>p</i> < .001), age (<i>p</i> = .012), and education (<i>p</i> < .001). Aim 3 (<i>n</i> = 1,101): 72.39% of participants overestimated demand intensity, with lower baseline cigarettes smoked/day, younger age, and nonmentholated cigarette use predicting overestimation (<i>p</i>s ≤ .038). Overall, this study demonstrates that CPT demand intensity often but modestly overestimates actual consumption, while nevertheless remaining equisensitive to differences in smoking risk as actual consumption, thereby supporting its utility and construct validity. Demand intensity overestimation is independently predicted by lighter smoking, younger age, and use of nonmentholated cigarettes. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expectations versus reality: Associations among anticipated, natural environment, and laboratory-derived alcohol stimulation, sedation, and reward.","authors":"Emily A Atkinson, Niloufar Dousti Mousavi, Daniel J Fridberg","doi":"10.1037/pha0000842","DOIUrl":"10.1037/pha0000842","url":null,"abstract":"<p><p>Subjective responses to alcohol (alcohol stimulation, sedation, liking, and wanting more) are important predictors of hazardous drinking. These are typically measured in real time via fixed-dose laboratory alcohol challenge or ecological momentary assessment (EMA), methods that can be prohibitively time- and resource-intensive. The present study examined the correspondence between self-report measures of anticipated alcohol responses and those same responses measured via the Biphasic Alcohol Effects Scale, Brief Biphasic Alcohol Effects Scale, and Drug Effects Questionnaire during a naturalistic drinking episode and a controlled laboratory alcohol challenge. Participants were 220 heavy-drinking adults (42% female; <i>M</i>_age = 26.3 years) who completed the anticipated Biphasic Alcohol Effects Scale and the anticipated Drug Effects Questionnaire and versions of these scales during a single high-resolution EMA of a naturalistic drinking episode. A subset of participants (<i>n</i> = 83) also completed versions of these scales during a fixed-dose laboratory alcohol challenge (0.8 g/kg alcohol). Anticipated stimulation, sedation, liking, and wanting more each significantly predicted their corresponding high-resolution EMA counterparts. Models predicting laboratory-derived subjective responses 30 and 60 min after beverage consumption found that alcohol stimulation and sedation were strong predictors of corresponding responses in the lab, but the same was not true for alcohol liking or wanting more. The present study extends prior work and suggests that heavy drinkers can predict their real-time subjective responses to alcohol with relative accuracy. Findings also provide further support for the use of self-report measures of anticipated alcohol responses, particularly stimulation and sedation, when real-time assessment methods (i.e., EMA or laboratory alcohol challenge) are not feasible. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"435-443"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13025791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Bifidobacterium longum 1714 on low mood and related symptoms: A randomized, double-blind, placebo-controlled trial.","authors":"Kelly M Seamans, Elaine Patterson, Caterina Holz, David Groeger, Jouni Junnila, Fergus Collins, Eileen F Murphy, Katy Sorensen, Timothy G Dinan","doi":"10.1037/pha0000839","DOIUrl":"10.1037/pha0000839","url":null,"abstract":"<p><p>Psychobiotics have been suggested as an alternative or adjunctive intervention for depressive symptoms. <i>Bifidobacterium longum (B. longum</i>) 1714 has previously been shown to influence stress response and sleep quality. This double-blind, placebo-controlled trial investigated whether <i>B. longum</i> 1714 (1 × 10¹⁰ colony-forming units/day) affects severity of depressive symptoms in 168 adults (aged 18-70) with mild to moderate depression over 8 weeks. The primary outcome was the change in Beck's Depression Inventory-II scores. Secondary outcomes included changes in sleep quality and mental wellness, measured by the Pittsburgh Sleep Quality Index, Patient Health Questionnaire-9, Short Form Health Survey-36, Cohen's Perceived Stress Scale, Visual Analogue Scales for fatigue and energy, and the adapted Global Clinical Impression. Changes in Beck's Depression Inventory-II scores from baseline were not significantly different between intervention and placebo at Week 4 (-0.303, 95% CI [-1.957, 1.35]; <i>p</i> = .718) or Week 8 (-1.432, 95% CI [-3.30, 0.44]; <i>p</i> = .132). However, at Week 4, decreases in both Pittsburgh Sleep Quality Index total score and Patient Health Questionnaire-9 were significantly greater in the intervention group compared with placebo with differences of -0.923 (95% CI [-1.62, -0.23]; <i>p</i> = .009) and -1.013 (95% CI [-2.00, -0.02]; <i>p</i> = .045), respectively, but no statistically significant differences were detected between the groups at Week 8. At Week 4, B. longum 1714 significantly improved subscores for Short Form Health Survey-36 (vitality, <i>p</i> = .038; mental health, <i>p</i> = .032; social role functioning, <i>p</i> = .033) compared with placebo, with vitality remaining significant at Week 8 (<i>p</i> = .042). Findings suggest that <i>B. longum</i> 1714 is safe and may exert fast-acting positive effects on various aspects of mood and mental wellness. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"341-351"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147812954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of stimulant medication on neuropsychological functioning in college students without ADHD.","authors":"John M Vasko, Alison Looby, Judah Warren Serrano, Tamara M Abu-Ramadan, Emily A Miller, Nancy McGee, Derek T Smith, Cynthia M Hartung","doi":"10.1037/pha0000853","DOIUrl":"10.1037/pha0000853","url":null,"abstract":"<p><p>Nonmedical prescription stimulant use is prevalent among college students despite no evidence of meaningful neuropsychological improvement in students without attention-deficit/hyperactivity disorder (ADHD). The present study addresses methodological limitations of existing placebo-controlled stimulant administration research by including a within-subject design, baseline comparison, and self-report/subjective measures of neuropsychological functioning to better clarify evidence of cognitive enhancement among college students without ADHD. Participants (<i>n</i> = 21) completed a no-drug baseline session and two counterbalanced experimental sessions that involved ingesting a placebo capsule or an amphetamine-dextroamphetamine immediate release 10 mg capsule. For each session, participants completed objective and self-report/subjective neuropsychological measures. Results indicated no significant differences across sessions for self-report/subjective measures and most objective measures. Specifically, for two outcomes on an objective measure (i.e., continuous performance task-identical pairs), performance improved in either the stimulant and placebo conditions compared to baseline or only the placebo condition compared to baseline. Taken together, the results of this study provide further evidence that stimulant medication does not confer neuropsychological improvement in students without ADHD, and perceived improvements may be better attributed to placebo, rather than pharmacological effects of a stimulant medication for this group. This information can inform ongoing efforts to discourage nonmedical prescription stimulant among college students without ADHD. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"426-434"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147867348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disentangling the bidirectional associations of depressive symptoms, impulsivity, and substance use in early adolescence: A between- and within-person perspective.","authors":"Timothy I Lawrence, Lu Chen, Oi-Man Kwok, Briana Amador, Lily Palmer, Gabriel J Merrin","doi":"10.1037/pha0000852","DOIUrl":"10.1037/pha0000852","url":null,"abstract":"<p><p>Adolescents internalizing symptoms, such as depressive features, and externalizing behaviors, including impulsive tendencies and substance use, have serious social and developmental implications. Although studies have highlighted the developmental impact, few studies have estimated the distinct and cross-predictive associations of these internalizing and externalizing challenges from both a between-person and within-person perspective. Therefore, guided by relevant psychopathology models, the present study (a) estimated the continuity of depressive symptoms, impulsivity, and substance use and (b) explored the cross-predictive associations of these constructs from between- and within-person perspectives. A total of 4,718 early adolescents (<i>M</i>_age = 11.23 years at Time 1) completed surveys at baseline and were reassessed at a 6-month time interval. Methodologically, the present study utilized a random-intercept cross-lagged panel model to estimate the distinct continuity and cross-comorbidities of depressive symptoms, impulsive tendencies, and substance use. Results indicated that the onset and continuity of depressive symptoms were apparent but not for impulsive tendencies and substance use. At the between level, there are associations across depressive symptoms, impulsive tendencies, and substance use. At the within-person level, substance use at Time 1 negatively predicted depressive symptoms and impulsivity at Time 2. Substance use at Time 2, in turn, positively predicted both depressive symptoms and impulsive tendencies at Time 3. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"444-452"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}