Experimental and clinical psychopharmacology最新文献

{"title":"Comparing current veterans affairs contingency management incentive structures against common alternatives on intentions to abstain from alcohol among veterans.","authors":"William Middleton, Mark Rzeszutek, Carolyn Lauckner, Sarah Iglehart, Carl Bou Mansour, Mikhail Koffarnus","doi":"10.1037/pha0000867","DOIUrl":"10.1037/pha0000867","url":null,"abstract":"<p><p>The purpose of this study was to compare the current U.S. Veteran Affairs (VA) contingency management incentives (vouchers to the VA Canteen) against other incentives for inducing intentions to use alcohol. Theory indicates that other incentives, such as debit cards, could be more effective at reducing drinking intentions. Sixty U.S. Armed Forces veterans who reported hazardous alcohol use were recruited for a virtual study through Prolific crowdsourcing. Participants responded on a 0-100 Likert scale of how likely they were to abstain from drinking if offered increasing compensation by vouchers, gift cards, and restricted and unrestricted debit cards. Price sensitivity and intensity of demand between each incentive type were compared. The sample was primarily male and White, and 68.9% of participants only utilized VA Canteens once per year or less. VA vouchers did not differ significantly on demand indices from VA gift cards; however, both debit cards produced higher likelihood of intentions to abstain from drinking than either VA gift cards or vouchers. This study is the first to assess the efficacy of incentive types within the VA contingency management framework and estimate their efficacy compared with vouchers. These results indicate that unrestricted and restricted debit cards should be assessed as alternatives to Canteen vouchers. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"511-518"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13390782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gimmie the Gummies: Initial validation of the Edibles Marijuana Purchase Task.","authors":"Elizabeth R Aston, Michael Amlung","doi":"10.1037/pha0000863","DOIUrl":"10.1037/pha0000863","url":null,"abstract":"<p><p>The traditional Marijuana Purchase Task (MPT) assesses hypothetical demand (i.e., relative value) for cannabis flower across escalating prices and has been related to cannabis use, cannabis expenditure, and cannabis use disorder symptoms. However, the MPT is specific to demand for cannabis flower, resulting in limited utility for individuals who endorse the use of other cannabis formulations, including edibles. The present investigation aimed to validate a novel measure of cannabis edible demand: the Edibles MPT (eMPT). Data were drawn from two samples (i.e., laboratory: <i>n</i> = 74; crowdsourced: <i>n</i> = 131) who endorsed use of cannabis edibles. Participants completed the eMPT, as well as key cannabis use outcome measures including the Cannabis Use Disorders Identification Test-Revised and cannabis expenditures. Demand data from the eMPT were highly systematic and prototypical across samples. Individual-level demand curves showed substantial variability in consumption. Multiple eMPT indices were significantly intercorrelated (laboratory: |<i>r_s</i>| = .43-.93; crowdsourced: |<i>r_s</i>| = .36-.89), correlated with corresponding MPT indices (laboratory: |<i>r_s</i>| = .52-.69; crowdsourced: |<i>r_s</i>| = .47-.74), and associated with Cannabis Use Disorders Identification Test-Revised scores and cannabis expenditures (laboratory: |<i>r_s</i>| = .24-.54; crowdsourced: |<i>r_s</i>| = .23-44). Additionally, the eMPT differentiated participants in the crowdsourced sample based on hazardous cannabis use via the Cannabis Use Disorders Identification Test-Revised; participants exhibiting hazardous use showed significantly greater intensity, breakpoint, and Omax and lower elasticity (<i>p</i>s < .03; <i>d</i>s .18-.67). These findings demonstrate that the eMPT is a valid assessment of cannabis edible demand and fulfills an unmet need in the cannabis demand literature for edible-specific purchase tasks. Subsequent research should continue to develop purchase tasks for other increasingly prevalent cannabis formulations due to the proliferation of novel cannabis products in the recreational market. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"467-478"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13317729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the neuroactive steroid precursor pregnenolone on stress- and alcohol cue-provoked pain responses in individuals with alcohol use disorder.","authors":"Riley Quinlan, Huaze Gao, Rajita Sinha, Verica Milivojevic","doi":"10.1037/pha0000862","DOIUrl":"10.1037/pha0000862","url":null,"abstract":"<p><p>Chronic alcohol use reduces GABAergic activity and neuroactive steroid levels, contributing to stress response dysregulation and heightened pain sensitivity in individuals with alcohol use disorder (AUD). Neuroactive steroid precursor pregnenolone (PREG) reduces stress- and cue-related craving and anxiety responses in individuals with AUD, but its effects on pain responses in AUD have not been assessed. Sixty treatment-seeking men and women with AUD in an 8-week randomized trial receiving placebo (PBO; <i>n</i> = 21), 300 mg PREG/day (<i>n</i> = 21), or 500 mg PREG/day (<i>n</i> = 18) completed a 3-day script-guided imagery provocation in Week 2. Following exposure to stress (S), alcohol cue (C), and neutral (N) conditions (administered across three separate laboratory days in a counterbalanced order), participants provided self-reports of pain, craving, and anxiety before, immediately after, and at various time points following the provocation. Analyses utilized a mixed factorial design with medication as a between-subjects factor and imagery condition and time point as within-subjects factors. The 300-mg PREG group did not exhibit significant increases in stress- or cue-induced pain compared with neutral condition (S:N: <i>p</i> = .705; C:N: <i>p</i> = .705), whereas increases in stress-induced pain in PBO (S > N: <i>p</i> = .009; C:N: <i>p</i> = .152) and stress- and cue-induced pain in the 500-mg PREG group (S > N: <i>p</i> < .001; C > N: <i>p</i> = .002) were observed. Pain was associated with alcohol craving (<i>p</i> < .001) and anxiety (<i>p</i> < .001). A PREG treatment effect showed positive associations between pain and alcohol craving in the PREG groups (300 mg: <i>p</i> < .001; 500 mg: <i>p</i> < .001) but not PBO (<i>p</i> = .962) and positive associations between pain and anxiety in the 300-mg PREG group (300 mg: <i>p</i> < .001) but not the PBO or 500-mg PREG groups (PBO: <i>p</i> = .325; 500 mg: <i>p</i> = .213). PREG dose specifically reduced stress-provoked pain responses and affected concurrent pain and craving and anxiety associations, warranting further examination of PREG effects on pain and alcohol use outcomes in AUD. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"532-545"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13251320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility data from a novel laboratory model of spontaneous opioid withdrawal.","authors":"Dhathri Srungaram, Natalia Rincon, Caitlyn J Durgin, Kelly E Dunn, Cecilia L Bergeria","doi":"10.1037/pha0000850","DOIUrl":"10.1037/pha0000850","url":null,"abstract":"<p><p>Gaps in knowledge surrounding opioid withdrawal complicate treatment, resulting in high rates of treatment attrition. Naloxone challenges are a rigorous method used to study withdrawal but can fail to capture broader, delayed-onset withdrawal symptoms. This study examines the feasibility of a novel paradigm of spontaneous opioid withdrawal among individuals with opioid use disorder maintained on methadone and assesses multidimensional aspects of withdrawal symptoms, including sleep, pain, and mood. Adults (N = 3) maintained on methadone were recruited from the community and completed a 3-day residential study. Participants received 50% of their prescribed methadone dose at admission and were observed for 57 hr without methadone. Meanwhile, participants completed self-report surveys on opioid withdrawal symptoms (i.e., Subjective Opiate Withdrawal Scale), pain, sleep, mood, and craving. Vital signs and physiological measures were also collected. The Subjective Opiate Withdrawal Scale scores peaked from \"moderate\" to \"severe\" withdrawal on study Day 3: +35, ±48 hr postdose, and anxiety was the only symptom consistently elevated across participants. Participants reported the greatest change in pain severity and interference scores from baseline on Day 3. Average pupil size increased over time. Meaningful elevations of symptoms occurred about 48 hr postpartial methadone dose administration, highlighting the significance of a longer observation period with these specific parameters. Examining spontaneous opioid withdrawal in individuals on methadone is feasible and offers an opportunity to investigate multidimensional elements of withdrawal. Testing novel models addresses the need for tools to assess and evaluate treatments targeting opioid withdrawal syndrome. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"575-581"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147867428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further adaptation of cross-commodity purchase task methodology: The impact of preference rank on demand.","authors":"Sarah C Weinsztok, Derek D Reed, Michael Amlung","doi":"10.1037/pha0000872","DOIUrl":"10.1037/pha0000872","url":null,"abstract":"<p><p>A behavioral economic framework of alcohol use posits that alcohol use is a temporally extended pattern of behavior and occurs in contexts in which other response options are available. Hypothetical purchase tasks are based in behavioral economic theory and allow for researchers to pinpoint demand for commodities. An extension of purchase task methodology, cross-commodity tasks examine demand for a substance when two or more commodities are concurrently available. Recent research has extended these tasks to examine the impact of competing activities on alcohol demand. The present study extends this work by examining the extent to which rank-order preference for alternative activities would differentially impact demand for alcohol and serve as substitutes. Participants were crowdsourced via Prolific and completed a rank-order assessment of preference of activities and hobbies, an alcohol purchase task, and measures of suitability and rewarding value of alcohol-related activities. They responded to three separate cross-commodity tasks in which the highest, second-highest, or lowest preferred activity was presented at fixed low cost, while the price of alcohol increased. Results indicated that though rank preference did not impact substitutability of activities for alcohol, demand for alcohol was greater suppressed in the presence of high-preferred than low-preferred activities. Additionally, reported consumption of activities was greatest when the activities were highly preferred. Taken collectively, results highlight the utility of purchase task methodology and demand curve analyses in identifying alternative activities and the need for continued research exploring the functional reinforcing components of alternative activities to incorporate in interventions for hazardous alcohol use. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"564-574"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13449185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term lithium treatment modulates excitation/inhibition balance in resting-state electroencephalography (EEG) among survivors of medically severe suicide attempts.","authors":"Nicholas Murphy, Ynhi T Thomas, Ioana Murgulet, Krisha Shah, Julia Engelhardt, Nidal J Moukaddam, Thomas R Kosten, Sanjay J Mathew, Alan C Swann","doi":"10.1037/pha0000857","DOIUrl":"10.1037/pha0000857","url":null,"abstract":"<p><p>Short-term lithium treatment may reduce impulsivity and suicide risk by stabilizing cortical signaling in high-risk individuals. The present double-blind, placebo-controlled, crossover study enrolled survivors of medically severe suicide attempts and recorded 2-min eyes-open resting-state electroencephalography at baseline (drug-naïve), after 4 weeks of lithium carbonate, and after 4 weeks of placebo (<i>n</i> = 10 completers). Analysis focused on spectral power across traditional frequency bands (delta through gamma) and the aperiodic slope of the power spectrum, a marker of excitation/inhibition balance in cortical networks. Treatment with lithium significantly increased gamma-band power relative to both baseline and placebo and flattened the aperiodic slope compared to baseline (<i>p</i> < .001). Other frequency band changes (beta, alpha) showed drug effects in analysis of variance but lacked consistent post hoc support. The increase in gamma power and alteration in aperiodic slope suggest engagement of cortical network mechanisms consistent with restored excitation/inhibition balance and enhanced neural synchrony. These preliminary neurophysiological findings support the possibility that electroencephalography-based measures could serve as objective biomarkers for lithium's neural effects in individuals at high suicide risk and warrant further large-scale studies integrating behavior and neurochemistry. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"617-624"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remotely delivered episodic future thinking and contingency management for smoking cessation: A randomized feasibility trial among military veterans in the United States.","authors":"Anthony N Nist, Rafaela M Fontes, Allison N Tegge, Roberta Freitas-Lemos, Lisa Kaiser, Kirstin M Gatchalian, Jeffrey S Stein, Warren K Bickel, Christine E Sheffer","doi":"10.1037/pha0000879","DOIUrl":"10.1037/pha0000879","url":null,"abstract":"<p><p>Cigarette smoking is a leading cause of death and disease in the United States and a significant concern for U.S. military veterans, who use tobacco at higher rates than nonveterans. Veterans face multiple obstacles to achieving long-term abstinence from smoking and might benefit from remotely delivered, novel approaches to smoking cessation treatment. This study employed reinforcer pathology theory to design a novel, accessible treatment approach that combined episodic future thinking with contingency management (EFT + CM) in a remotely delivered treatment for military veterans. Veterans (n = 97) participated in a 16-week, randomized control, single-blind, remotely delivered, feasibility study. The treatment phase was conducted from Week 1 to 12 with EFT delivered from Week 1 to 12 and CM delivered from Week 1 to 4. All participants received 12 weeks of nicotine patches. Feasibility measures included demand, adherence, practicality, acceptability, and limited efficacy testing. Across conditions, all feasibility measures were within acceptable ranges. The study enrolled 88% of eligible participants, and about two thirds completed the final outcome assessment. Adherence to submitting daily breath samples and to reviewing daily cues was over 80% and was acceptable across conditions. Relative to baseline, delay discounting rates decreased in the EFT + CM condition showing large effect sizes across time and small effect sizes in the control condition. The EFT + CM condition also showed a higher proportion of breath samples that reflected abstinence than those in the control condition. In conclusion, multiple indicators of feasibility suggest that a remotely delivered EFT + CM combined with nicotine patches is feasible and warrants further investigation. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":"34 5","pages":"498-510"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the sensory effects of menthol and synthetic coolants in e-liquids: A pilot investigation.","authors":"Danielle R Davis, Wei Li, Ran Wu, Ralitza Gueorguieva, Remi A Mellinghoff, Julie B Zimmerman, Hanno C Erythropel, Suchitra Krishnan-Sarin","doi":"10.1037/pha0000865","DOIUrl":"10.1037/pha0000865","url":null,"abstract":"<p><p>Synthetic coolants such as Wilkinson Sword-23 (WS-23) and Wilkinson Sword-3 (WS-3) are commonly included either instead or with menthol in e-liquids. While in vitro studies suggest that synthetic coolants have similar cooling properties as menthol, less is known about their sensory effects in humans. This study is the first to directly compare sensory effects following inhalational exposure to synthetic coolants and menthol in e-liquids. Adults who used e-cigarettes (<i>N</i> = 27; 33.3 ± 10.0 years; 40.7% female) completed one laboratory session. Under randomized double-blinded conditions, participants sampled e-liquids containing menthol, WS-3, or WS-23. Sixteen e-liquids were sampled in commercially relevant concentrations: 0.5 mg/g, 1 mg/g, 5 mg/g, 10 mg/g, 20 m/g for all coolants, and 40 mg/g for WS-23 only. Participants reported sensory effects (coolness, flavor intensity, sweetness, irritation). Mixed-effects models assessed effects of coolant, concentration, and their interaction. Within each coolant, coolness, flavor, and irritation increased with concentration (<i>p</i>s < .05). Coolness and flavor intensity differed by coolant (<i>p</i>s < .05). Menthol and WS-23 produced stronger cooling than WS-3, and menthol had stronger flavor intensity than both WS-3 or WS-23 (<i>p</i>s < .05). Sweetness and irritation did not differ by coolant. Across coolants, we observed dose-dependent increases in sensory effects across concentrations. While all coolants produced cooling and flavor intensity that increased with increasing concentration, WS-23 more closely matched menthol's cooling effect. Neither synthetic coolant had as strong a flavor intensity as menthol. Our evidence suggests that sensory effects of synthetic coolants may substitute for menthol's cooling properties. Future studies are needed to understand if synthetic coolants similarly to menthol, enhance the appeal of nicotine-containing e-liquids. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"479-488"},"PeriodicalIF":1.6,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of simulated and real opioid withdrawal on delay discounting for opioids and money in people who use fentanyl daily.","authors":"Thomas P Shellenberg, Tavishi Baidwan, Alexandra N Johansen, Justin C Strickland, Suky Martinez, Sean D Regnier, Michael J Wesley, Shanna L Babalonis, William W Stoops, Joshua A Lile","doi":"10.1037/pha0000878","DOIUrl":"10.1037/pha0000878","url":null,"abstract":"<p><p>Delay discounting describes the devaluation of consequences as the delay to their occurrence increases, which can yield a preference for smaller, sooner over larger, later rewards. Conceptual models and preliminary data suggest that delay discounting is exacerbated in deprivation states, including opioid withdrawal, which can shift choice allocation to more immediate rewards. Although withdrawal is hypothesized to affect decision making in opioid use disorder, research that experimentally manipulates withdrawal in people with opioid use disorder is limited by feasibility considerations. Simulated withdrawal manipulations could address this gap, but their validity is not well established. The current analysis compared the effects of real and simulated opioid withdrawal on delay discounting in people with moderate-to-severe opioid use disorder and daily fentanyl use by combining data from two previous studies. Study 1 (<i>n</i> = 12) elicited opioid withdrawal via double-blind, placebo substitution of oxycodone maintenance medication during inpatient admission. Study 2 (<i>n</i> = 17) simulated opioid withdrawal via verbal instructions to outpatient participants. All participants completed five-trial, adjusting delay discounting tasks for money and opioid pills. Linear mixed models revealed steeper rates of discounting of delayed opioid pills during opioid withdrawal, regardless of withdrawal manipulation modality (real or simulated). Delay discounting for money was steeper in the simulated withdrawal group only, potentially reflecting pre-existing group differences in the sensitivity of money discounting during withdrawal. These results are consistent with prior research and support the use of simulated withdrawal as an effective experimental proxy in decision-making studies when real withdrawal manipulations are not feasible or warranted. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and multilevel structure of a day-level failed control over Alcohol Use Scale.","authors":"Jack T Waddell, Nioud Mulugeta Gebru, Michael Erickson, Dylan K Moran","doi":"10.1037/pha0000880","DOIUrl":"https://doi.org/10.1037/pha0000880","url":null,"abstract":"<p><p>Failed control over alcohol use is a hallmark symptom of alcohol use disorder, one that has been extensively (and precisely) measured across individuals. Yet our ability to measure failed control at the day level, when drinking naturally occurs, is hampered by a lack of consistent, ecologically validated measurement tools. The present study filled this void in the literature. College students who binge drink (<i>N</i> = 272) completed a baseline assessment and 14 days of daily diaries. During daily diaries, participants reported their drinking behavior, alcohol consequences, and intentions while also responding to 10 items adapted from the Impaired Control Scale assessing failed control and one item assessing attempted control. Nine of the 10 items assessing failed control loaded well onto a multilevel latent factor-one item assessing unplanned drinking did not and was removed. The nine-item failed control scale showed convergent validity, being positively correlated with exceeding intoxication intentions at the day level and with baseline failed control at the person level. The nine-item failed control scale also showed discriminant validity, being negatively correlated with day-level attempted control. In terms of concurrent/incremental validity, the nine-item failed control scale predicted heavier drinking and more negative consequences at the day level and person level, and such relations remained even when accounting for day-level exceeding intoxication intentions and attempted control, as well as baseline failed/attempted control across people. Failed control can be effectively measured in daily life within and across drinking episodes via the nine items tested herein, and investigators could include such items in future day-level research protocols. (PsycInfo Database Record (c) 2026 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}