Experimental and clinical psychopharmacology最新文献

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Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task. 在递进比例任务中,对酒精的主观反应预测了自我管理酒精的动机。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-07-24 DOI: 10.1037/pha0000792
Malia A Belnap, Dylan E Kirsch, Erica N Grodin, Lara A Ray
{"title":"Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task.","authors":"Malia A Belnap, Dylan E Kirsch, Erica N Grodin, Lara A Ray","doi":"10.1037/pha0000792","DOIUrl":"https://doi.org/10.1037/pha0000792","url":null,"abstract":"<p><p>Subjective responses to alcohol, which encompass the subjective feelings and experiences elicited by alcohol consumption, are important factors implicated in the etiology of alcohol use disorder. Previous human laboratory studies have investigated how subjective responses to priming doses of alcohol influence alcohol self-administration (SA) but have not accounted for responses throughout the task. The present study investigated how subjective responses to alcohol, measured at multiple time points during a progressive ratio SA task, impacted subsequent motivation to self-administer alcohol. Participants (<i>n</i> = 67; 36 male/31 female) who drank heavily completed a 120-min progressive ratio alcohol intravenous SA paradigm. Every 15 min, participants were breathalyzed and completed self-report questionnaires to measure alcohol-induced stimulation, sedation, alcohol wanting, alcohol liking, negative mood, and positive mood. Alcohol SA was indicated by an increase in breath alcohol concentration. Time-lagged subjective response outcomes were examined as predictors of subsequent SA using multilevel modeling. Sex and family history of alcohol-related problems were investigated as potential moderators of the impact of subjective response measures on SA. Higher levels of alcohol-induced stimulation, as well as wanting and liking alcohol, predicted increased SA of alcohol. An increase in time, as a proxy for task demand, predicted a decreased likelihood of subsequent SA and moderated the effect of liking on SA. Family history of alcohol-related problems moderated the impact of alcohol-induced wanting and negative mood on motivation to consume alcohol. Overall, these findings emphasize the significant role of subjective responses to alcohol, as well as their interactions with task demand and family history, in influencing alcohol consumption behaviors. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-reported changes and experiences with substance use among real-world patients treated with medical ketamine. 现实世界中接受医用氯胺酮治疗的患者自我报告的物质使用变化和经历。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-07-24 DOI: 10.1037/pha0000788
Shahar Almog, Maribel Rodriguez Perez, Deepthi S Varma, Alexia N Obrochta, Michelle Weiner, JeeWon Cheong, Meredith S Berry
{"title":"Self-reported changes and experiences with substance use among real-world patients treated with medical ketamine.","authors":"Shahar Almog, Maribel Rodriguez Perez, Deepthi S Varma, Alexia N Obrochta, Michelle Weiner, JeeWon Cheong, Meredith S Berry","doi":"10.1037/pha0000788","DOIUrl":"https://doi.org/10.1037/pha0000788","url":null,"abstract":"<p><p>Ketamine is increasingly used in community clinics as a long-term treatment for different psychiatric and pain conditions, including substance use disorders. Data are lacking, however, regarding the potential influence of ketamine on other substance use. In this secondary analysis, we aimed to explore the relationship between medical ketamine and other substance use among real-world patients by combining quantitative and qualitative data. In an online anonymous pilot survey (<i>N</i> = 201), patients rated change in other substance use since medical ketamine initiation and elaborated on their subjective experiences. Most patients self-reported positive/desirable change (54.7%) or no change in substance use (44.3%). Participants reporting past problematic substance use had significantly greater positive change compared with the groups of participants reporting present or no history of problematic substance use (<i>p</i>s < .020). Participants reported positive outcomes such as reduced substance use due to reduced need to self-medicate for coping, reduced craving, or enhanced motivation to quit use. Among participants with minimal or no substance use, ketamine did not appear to induce or increase drug-using behaviors. However, there were some reports of risky behaviors such as openness to using other psychedelics or ketamine used recreationally as a substitute for alcohol. Several implications for providers are discussed. More targeted quantitative and qualitative research is needed to fully characterize all patients but especially those at risk for potentially harmful nonmedical substance use. Such research could inform regulation efforts on safety, screening, monitoring, and patient and provider education, to maximize benefits and minimize risks related to medical ketamine. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone. 在门诊丁丙诺啡辅助过渡到注射纳曲酮期间,加巴喷丁与安慰剂诱导的阿片类药物使用障碍患者心率变异性的探索性研究。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-07-10 DOI: 10.1037/pha0000784
Lauren R Fitzgerald, Jackson W Weaver, Michael J Mancino, Merideth A Addicott, Linda J Larson-Prior, Jeff D Thostenson, Alison H Oliveto
{"title":"Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.","authors":"Lauren R Fitzgerald, Jackson W Weaver, Michael J Mancino, Merideth A Addicott, Linda J Larson-Prior, Jeff D Thostenson, Alison H Oliveto","doi":"10.1037/pha0000784","DOIUrl":"https://doi.org/10.1037/pha0000784","url":null,"abstract":"<p><p>We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection naltrexone to explore how adjunctive pharmacotherapy and time influence autonomic nervous system activity and whether HRV metrics are predictive of treatment outcomes. Individuals with opioid use disorder who began their participation in an ongoing trial of adjunct gabapentin during an outpatient 10-day buprenorphine-assisted transition to injection naltrexone underwent experimental sessions at Weeks 1, 2, and 3 of the parent trial. HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What were you thinking? Relations between cannabis expectancies and use behavior depend upon self-attributed modality and type of cannabis. 你在想什么?大麻期望与使用行为之间的关系取决于大麻的自我归属方式和类型。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-07-10 DOI: 10.1037/pha0000789
Jack T Waddell
{"title":"What were you thinking? Relations between cannabis expectancies and use behavior depend upon self-attributed modality and type of cannabis.","authors":"Jack T Waddell","doi":"10.1037/pha0000789","DOIUrl":"https://doi.org/10.1037/pha0000789","url":null,"abstract":"<p><p>Self-report is the most common way to measure substance use expectancies. Using such measures has led to insights regarding how, why, and for whom expectancies relate to use behavior. In fact, such insights have translated into interventions, such as expectancy challenges seeking to change one's expectancies. However, expectancy measures may be tricky for cannabis use, which has several product types and modalities that may impact the introspection of self-reported cannabis experiences. This study assessed whether a modern expectancies measure was invariant across cannabis use type/modality self-reported upon and whether cannabis type/modality moderated the influence of expectancies on use behavior. Young adults who recreationally used cannabis (<i>N</i> = 387) reported their cannabis use frequency and expectancies via the Anticipated Effects of Cannabis Scale. Participants also reported cannabis modality/type through which expectancies were self-reported upon. Each expectancy domain (high arousal negative, low arousal negative, positive) was invariant across cannabis type/modality. High arousal negative expectancies were higher when reporting vaping versus smoking, and positive expectancies were higher when reporting smoking versus vaping, but no other differences emerged. However, positive expectancies were associated with more frequent cannabis use when reporting on smoked (vs. vaporized) cannabis, and high arousal negative expectancies were associated with less frequent cannabis use when reporting on hash oil (vs. marijuana) and when reporting on vaporized (vs. smoked) cannabis. Cannabis type and modality may be important qualifiers in self-report research on cannabis expectancies. Future research should consider assessing modality- and type-specific cannabis constructs that are susceptible to such influences. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Operant demand for cigarettes varies by unit of purchase: Comparing purchasing of packs and individual cigarettes. 对香烟的经营需求因购买单位而异:比较购买包装和单个香烟。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-07-03 DOI: 10.1037/pha0000787
Derek D Reed, Madison E Graham, Brett W Gelino, Justin C Strickland
{"title":"Operant demand for cigarettes varies by unit of purchase: Comparing purchasing of packs and individual cigarettes.","authors":"Derek D Reed, Madison E Graham, Brett W Gelino, Justin C Strickland","doi":"10.1037/pha0000787","DOIUrl":"https://doi.org/10.1037/pha0000787","url":null,"abstract":"<p><p>The operant demand cigarette purchase task conventionally prompts participants to report imagined purchases in units of single cigarettes. Although this purchasing modality diverges from the units deployed in real purchasing scenarios (i.e., packs of 20), no research has examined how simulated purchasing of the more ecologically valid unit of cigarette packs maps onto single cigarette purchasing metrics. A sample of 212 participants in this study reported hypothetical cigarette purchases across three iterations of the cigarette purchase task. Two of these collected responses in a binary format-would or would not purchase-at yoked unit prices, where tasks were distinguished as purchases of single cigarettes or packs of cigarettes. This binary framework permitted a simplified probabilistic description of purchasing that maintained a consistent timeframe. Participants also completed the standard cigarette purchase task, reporting the quantity of single cigarettes they would purchase and consume at each unit price. Purchasing breakpoint, or the highest price at which participants reported purchasing cigarettes, was broadly consistent across these tasks, weakly so when comparing purchases made on the binary tasks (<i>r</i> = .183). Tests of equivalence suggested that there were meaningful differences between breakpoint values reported on the single cigarette binary task and the per pack binary task, <i>t</i>(211) = -5.85, <i>p</i> < .001, and between breakpoint values reported on the standard purchase task and the per pack binary task, <i>t</i>(211) = 11.49, <i>p</i> < .001. Results suggest more research is needed to determine what environmental factors or imposed constraints are practically influencing reported cigarette valuation. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of exercise interventions on substance-use outcomes: A meta-analytic and systematic review. 运动干预对药物使用结果的影响:荟萃分析和系统回顾。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-06-12 DOI: 10.1037/pha0000785
Hannah N Carlson, Mark A Smith, Justin C Strickland
{"title":"The effects of exercise interventions on substance-use outcomes: A meta-analytic and systematic review.","authors":"Hannah N Carlson, Mark A Smith, Justin C Strickland","doi":"10.1037/pha0000785","DOIUrl":"https://doi.org/10.1037/pha0000785","url":null,"abstract":"<p><p>A number of studies have been conducted to assess the efficacy of exercise-based interventions for substance-use disorders. Nicotine use has been overrepresented in prior meta-analytic and systematic reviews, potentially obscuring the effects of exercise on outcomes related to other drugs. The aim of this meta-analysis and systematic review was to offer an updated account of the impact of exercise on substance-use outcomes for drugs other than nicotine. Eligible studies included peer reviewed articles published before August 2023 describing randomized controlled trials or clinical trials involving adults in which exercise served as the primary treatment intervention and substance use and/or craving outcomes were assessed for drugs other than nicotine. In addition to omnibus effects, meta-regression models were conducted to assess study design (within vs. between), data collection (acute vs. long-term), and outcome measure (drug craving vs. drug use) as potential moderating variables. A total of 19 articles describing 17 unique studies were selected for analysis, including data from 1,363 individual participants. An omnibus robust variance estimation meta-analysis indicated a significant reduction in substance-use outcomes following exercise intervention. The moderator analysis additionally indicated a significant effect of design type such that between-subject designs displayed smaller magnitude reductions than within-subject designs. Other potential moderators were not significant. These findings indicate that a variety of exercise-based interventions produce moderate improvements in substance use and craving for people using nonmedical drugs and corroborate prior reports that exercise is effective as an adjunctive or standalone treatment for substance-use disorder. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of "ice" components in sweet-flavored nicotine-containing e-liquids among young adult e-cigarette users. 含尼古丁的甜味电子烟液体中的“冰”成分对年轻成年电子烟使用者的影响。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-06-09 DOI: 10.1037/pha0000786
Wei Li, Danielle R Davis, Ran Wu, Ralitza Gueorguieva, Barry G Green, Suchitra Krishnan-Sarin
{"title":"The effect of \"ice\" components in sweet-flavored nicotine-containing e-liquids among young adult e-cigarette users.","authors":"Wei Li, Danielle R Davis, Ran Wu, Ralitza Gueorguieva, Barry G Green, Suchitra Krishnan-Sarin","doi":"10.1037/pha0000786","DOIUrl":"https://doi.org/10.1037/pha0000786","url":null,"abstract":"<p><p>E-cigarette use is prevalent among young adults, with \"ice\" e-cigarettes/liquids that combine sweet and cooling flavors becoming increasingly popular. This study examines if an \"ice\" component (e.g., menthol) alters liking, sensory experiences, and reward of sweet-flavored nicotine e-liquids among young adults. A double-blinded laboratory session was conducted with past-month e-cigarette users aged 18-20 (N = 40). Participants were exposed in random order to a sweet-flavored (watermelon) e-liquid with and without menthol in two 10-puff bouts. Both e-liquids contained 36 mg/ml nicotine salt and 50:50 propylene glycol/vegetable glycerin. Participants rated flavor liking and overall vaping experience using the Labeled Hedonic Scale, sensory effects using generalized Labeled Magnitude Scales, and reward effects using the Drug Effects Questionnaire. Linear mixed models analyzed outcomes with flavor condition, sex, and their interaction as fixed effects, adjusting for flavor order. Participants (average age = 19.1 years, <i>SD</i> = 0.8; 52.5% female and 67.5% White) used e-cigarettes on average 6.2 (<i>SD</i> = 1.5) days/week. Participants reported marginally less liking of the overall vaping experience for the watermelon flavor with menthol (<i>M</i> = -3.92 [<i>SE</i> = 3.16]) compared to the watermelon flavor without menthol (<i>M</i> = 1.27 [SE = 3.16], <i>p</i> = .05). No main effects of flavor, sex, or their interactions were observed in sensory and reward effects (<i>p</i>s > .05). Among our sample of young adult e-cigarette users, adding a cooling component to a sweet-flavored e-liquid did not result in altered liking, sensory, or reward effects compared to sweet-flavored e-liquid without cooling. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Negative urgency accounts for associations between internalizing symptoms and lifetime nonfatal opioid overdose among patients from three urban Ohio emergency departments. 负面急迫性解释了内化症状与俄亥俄州三个城市急诊科患者终生非致命性阿片类药物过量之间的关联。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-06-01 Epub Date: 2025-02-24 DOI: 10.1037/pha0000764
Dan Petrovitch, Katie P Himes, Emma Quarles, Caroline E Freiermuth, Robert S Braun, Joshua W Lambert, Jennifer L Brown, Michael S Lyons, Brittany E Punches, Jon E Sprague, Andrew K Littlefield
{"title":"Negative urgency accounts for associations between internalizing symptoms and lifetime nonfatal opioid overdose among patients from three urban Ohio emergency departments.","authors":"Dan Petrovitch, Katie P Himes, Emma Quarles, Caroline E Freiermuth, Robert S Braun, Joshua W Lambert, Jennifer L Brown, Michael S Lyons, Brittany E Punches, Jon E Sprague, Andrew K Littlefield","doi":"10.1037/pha0000764","DOIUrl":"10.1037/pha0000764","url":null,"abstract":"<p><p>Existing evidence relates internalizing psychopathology to nonfatal opioid overdose. Identifying variables that account for associations between internalizing symptomology and overdose could improve clinical conceptualizations of overdose risk and inform testable, mechanistic hypotheses. Mood-based facets of impulsivity, such as negative and positive urgency, are promising candidate variables that have been linked to both internalizing symptoms and negative substance use outcomes. Therefore, the present study tested whether these facets accounted for internalizing-overdose associations. We conducted a secondary, cross-sectional data analysis of lifetime opioid-exposed patients presenting to three large, urban emergency departments in Ohio. Bivariate associations between measures of internalizing conditions, mood-related urgency, and nonfatal opioid overdose were calculated, and the extent to which negative and positive urgency accounted for associations between internalizing constructs and nonfatal opioid overdose was examined. To determine the specificity of findings, we compared results to other impulsivity facets and models testing internalizing-impulsivity interactions. Negative urgency demonstrated a unique role in accounting for relationships between internalizing constructs and lifetime nonfatal opioid overdose. No other impulsivity facet, including positive urgency, reliably accounted for internalizing-overdose relations. No internalizing-urgency interactions were observed. Negative urgency was the only facet to reliably explain overlap in internalizing-overdose associations. Overdose-prevention efforts should consider the dual roles of internalizing symptoms and negative urgency as risk factors for opioid overdose. Implications for testing causal hypotheses are discussed. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"300-309"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic morphine impairs interoceptive control of avoidance: Implications for dysregulated drug intake. 慢性吗啡损害回避的内感受性控制:对药物摄入失调的影响。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-06-01 Epub Date: 2025-02-27 DOI: 10.1037/pha0000762
Shihui Huang, Sydney E Cerveny, Anna L Ruprecht, Ethan R Steere, Anushka Valsan, Anthony L Riley
{"title":"Chronic morphine impairs interoceptive control of avoidance: Implications for dysregulated drug intake.","authors":"Shihui Huang, Sydney E Cerveny, Anna L Ruprecht, Ethan R Steere, Anushka Valsan, Anthony L Riley","doi":"10.1037/pha0000762","DOIUrl":"10.1037/pha0000762","url":null,"abstract":"<p><p>Interoceptive drug states have been increasingly recognized as important cues that may help regulate intake by disambiguating postintake outcomes. While drug states signaling rewarding or reinforcing effects may occasion drug-taking and drug-seeking, states signaling aversive effects may be critical for terminating a drug-taking episode. Given that drug intake often becomes dysregulated with extensive exposure, the present study investigated whether chronic drug exposure impairs the function of interoceptive drug states to occasion avoidance. Male Sprague Dawley rats were trained in a discriminated taste avoidance procedure in which morphine (10 mg/kg, intraperitoneally) signaled that a saccharin solution would be followed by the illness-inducing agent lithium chloride, while the drug vehicle signaled that saccharin would not be followed by lithium chloride. Rats were then exposed to chronic morphine (CM) or chronic vehicle for 20 days. Morphine-induced stimulus control was tested at three doses (0, 5, and 10 mg/kg) following chronic exposure and a 3-week morphine-free period (dissipation of tolerance). Forty-five of the 49 rats acquired the discrimination, avoiding saccharin when it was preceded by morphine and consuming saccharin when it was preceded by saline. Chronic vehicle-exposed rats displayed dose-dependent avoidance on a subsequent test, while CM-exposed rats displayed no avoidance at any dose. Following a 30-day washout during which morphine was no longer administered, subjects in group CM injected with 10 mg/kg morphine avoided saccharin, displaying a partial recovery of discriminative control. These findings provide a baseline for the attenuating effects of chronic drug exposure on the drug's interoceptive control of avoidance. Further, by demonstrating that interoceptive control recovers after abstinence, the results suggest that tolerance may contribute to such impairment. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"248-259"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential discounting of past and future gains and losses in individuals in recovery from substance use disorder. 从物质使用障碍中恢复的个体对过去和未来收益和损失的差异贴现。
IF 2.4 3区 医学
Experimental and clinical psychopharmacology Pub Date : 2025-06-01 Epub Date: 2025-03-03 DOI: 10.1037/pha0000769
Rafaela M Fontes, Ana Carolina L Bovo, Roberta Freitas-Lemos, Warren K Bickel
{"title":"Differential discounting of past and future gains and losses in individuals in recovery from substance use disorder.","authors":"Rafaela M Fontes, Ana Carolina L Bovo, Roberta Freitas-Lemos, Warren K Bickel","doi":"10.1037/pha0000769","DOIUrl":"10.1037/pha0000769","url":null,"abstract":"<p><p>Individuals with substance use disorder (SUD) show consistently higher delay discounting (DD) rates than controls for both future and past outcomes, as well as for gains and losses. However, differences in these DD effects (e.g., tense and sign) among individuals in SUD recovery have yet to be explored. Therefore, the goal of the present study was to (a) investigate differences in discounting of past and future gains and losses among individuals in SUD recovery and (b) examine differences in these DD effects between individuals in different stages of remission (i.e., not in remission, in early remission, or in sustained remission). Our results indicate that individuals in recovery discount past and future gains, but not losses, symmetrically. Additionally, individuals in recovery discount gains more than losses (i.e., sign effect) for the future but not for the past. Finally, those in sustained remission showed significantly lower DD rates than those not in remission, regardless of the DD task. Thus, other discounting tasks might provide a similarly accurate measure of DD and can be employed to assess differences in discounting between those in remission and those not in remission. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"291-299"},"PeriodicalIF":2.4,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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