Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.

IF 2.2 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Experimental and clinical psychopharmacology Pub Date : 2025-10-01 Epub Date: 2025-07-10 DOI:10.1037/pha0000784
Lauren R Fitzgerald, Jackson W Weaver, Michael J Mancino, Merideth A Addicott, Linda J Larson-Prior, Jeff D Thostenson, Alison H Oliveto
{"title":"Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.","authors":"Lauren R Fitzgerald, Jackson W Weaver, Michael J Mancino, Merideth A Addicott, Linda J Larson-Prior, Jeff D Thostenson, Alison H Oliveto","doi":"10.1037/pha0000784","DOIUrl":null,"url":null,"abstract":"<p><p>We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection naltrexone to explore how adjunctive pharmacotherapy and time influence autonomic nervous system activity and whether HRV metrics are predictive of treatment outcomes. Individuals with opioid use disorder who began their participation in an ongoing trial of adjunct gabapentin during an outpatient 10-day buprenorphine-assisted transition to injection naltrexone underwent experimental sessions at Weeks 1, 2, and 3 of the parent trial. HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"439-447"},"PeriodicalIF":2.2000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1037/pha0000784","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0

Abstract

We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection naltrexone to explore how adjunctive pharmacotherapy and time influence autonomic nervous system activity and whether HRV metrics are predictive of treatment outcomes. Individuals with opioid use disorder who began their participation in an ongoing trial of adjunct gabapentin during an outpatient 10-day buprenorphine-assisted transition to injection naltrexone underwent experimental sessions at Weeks 1, 2, and 3 of the parent trial. HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

在门诊丁丙诺啡辅助过渡到注射纳曲酮期间,加巴喷丁与安慰剂诱导的阿片类药物使用障碍患者心率变异性的探索性研究。
在一项正在进行的双盲、安慰剂对照试验中,我们评估了心率变异性(HRV)作为自主神经系统功能的测量指标,该试验在丁丙诺啡辅助逐渐减少和过渡到注射纳曲酮期间使用加巴喷丁作为辅助药物治疗,以探索辅助药物治疗和时间如何影响自主神经系统活动,以及HRV指标是否可预测治疗结果。阿片类药物使用障碍患者在门诊10天丁丙诺啡辅助过渡到注射纳曲酮期间开始参与辅助加巴喷丁的持续试验,在母体试验的第1,2,3周进行实验。使用带有传感器带和分析套件的ProComp2系统,在进行有节奏呼吸(PB)时,分别在站立、坐着和坐着时评估HRV指标2分钟。由于一些参与者在所有三个每周时间点都缺乏数据,因此使用多重输入来分析HRV指标。在28名参与者中,逻辑回归分析显示PB运动的频率分布和心率有显著影响。PB期间的频率分布趋势提示加巴喷丁对自主神经平衡的潜在影响,导致HRV降低。结果的预测变量表明,在PB期间,较高的低频/高频比显著降低了完成监督戒断的几率。坐着时较高的呼吸频率和较低的频率值分别显示出降低第4周注射纳曲酮几率的趋势和显著效果。在监督阿片类药物戒断过程中,选定的HRV指标发生变化,并与监督阿片类药物戒断过程中的治疗结果相关。在PB练习中HRV指标的重要性强调了特定活动对自主功能的影响,强调了在记录HRV指标时考虑这种影响的重要性。(PsycInfo Database Record (c) 2025 APA,版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
4.20
自引率
8.70%
发文量
164
审稿时长
6-12 weeks
期刊介绍: Experimental and Clinical Psychopharmacology publishes advances in translational and interdisciplinary research on psychopharmacology, broadly defined, and/or substance abuse.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信