Lauren R Fitzgerald, Jackson W Weaver, Michael J Mancino, Merideth A Addicott, Linda J Larson-Prior, Jeff D Thostenson, Alison H Oliveto
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HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"439-447"},"PeriodicalIF":2.2000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.\",\"authors\":\"Lauren R Fitzgerald, Jackson W Weaver, Michael J Mancino, Merideth A Addicott, Linda J Larson-Prior, Jeff D Thostenson, Alison H Oliveto\",\"doi\":\"10.1037/pha0000784\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection naltrexone to explore how adjunctive pharmacotherapy and time influence autonomic nervous system activity and whether HRV metrics are predictive of treatment outcomes. Individuals with opioid use disorder who began their participation in an ongoing trial of adjunct gabapentin during an outpatient 10-day buprenorphine-assisted transition to injection naltrexone underwent experimental sessions at Weeks 1, 2, and 3 of the parent trial. HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>\",\"PeriodicalId\":12089,\"journal\":{\"name\":\"Experimental and clinical psychopharmacology\",\"volume\":\" \",\"pages\":\"439-447\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and clinical psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1037/pha0000784\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/10 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1037/pha0000784","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/10 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
在一项正在进行的双盲、安慰剂对照试验中,我们评估了心率变异性(HRV)作为自主神经系统功能的测量指标,该试验在丁丙诺啡辅助逐渐减少和过渡到注射纳曲酮期间使用加巴喷丁作为辅助药物治疗,以探索辅助药物治疗和时间如何影响自主神经系统活动,以及HRV指标是否可预测治疗结果。阿片类药物使用障碍患者在门诊10天丁丙诺啡辅助过渡到注射纳曲酮期间开始参与辅助加巴喷丁的持续试验,在母体试验的第1,2,3周进行实验。使用带有传感器带和分析套件的ProComp2系统,在进行有节奏呼吸(PB)时,分别在站立、坐着和坐着时评估HRV指标2分钟。由于一些参与者在所有三个每周时间点都缺乏数据,因此使用多重输入来分析HRV指标。在28名参与者中,逻辑回归分析显示PB运动的频率分布和心率有显著影响。PB期间的频率分布趋势提示加巴喷丁对自主神经平衡的潜在影响,导致HRV降低。结果的预测变量表明,在PB期间,较高的低频/高频比显著降低了完成监督戒断的几率。坐着时较高的呼吸频率和较低的频率值分别显示出降低第4周注射纳曲酮几率的趋势和显著效果。在监督阿片类药物戒断过程中,选定的HRV指标发生变化,并与监督阿片类药物戒断过程中的治疗结果相关。在PB练习中HRV指标的重要性强调了特定活动对自主功能的影响,强调了在记录HRV指标时考虑这种影响的重要性。(PsycInfo Database Record (c) 2025 APA,版权所有)。
Exploratory study of heart rate variability among participants with opioid use disorder inducted on gabapentin versus placebo during outpatient buprenorphine-assisted transition to injection naltrexone.
We assessed heart rate variability (HRV) as a measure of autonomic nervous system function during an ongoing double blind, placebo-controlled, trial of adjunct gabapentin during a buprenorphine-assisted taper and transition to injection naltrexone to explore how adjunctive pharmacotherapy and time influence autonomic nervous system activity and whether HRV metrics are predictive of treatment outcomes. Individuals with opioid use disorder who began their participation in an ongoing trial of adjunct gabapentin during an outpatient 10-day buprenorphine-assisted transition to injection naltrexone underwent experimental sessions at Weeks 1, 2, and 3 of the parent trial. HRV metrics were assessed for 2 min each while standing, sitting, and sitting while performing paced breathing (PB) using the ProComp2 System with sensor belt and analysis suite. Multiple imputation was used to analyze the HRV metrics due to some participants lacking data at all three weekly timepoints. Among 28 participants, logistic regression analyses indicated significant effects for frequency distributions and heart rate during PB exercises. Trends in frequency distribution during PB suggested potential influences of gabapentin on autonomic balance, resulting in lower HRV. Predictor variables for outcomes indicated a significant effect with higher low frequency/high frequency ratio during PB decreasing the odds of completing supervised withdrawal. Higher respiration rate and low frequency values while sitting showed trends and significant effects, respectively, for decreasing the odds of receiving Week 4 injection naltrexone. Selected HRV metrics change during supervised opioid withdrawal and are associated with treatment outcomes during supervised opioid withdrawal procedures. The significance of HRV metrics during PB exercises underscores the impact of specific activities on autonomic function, highlighting the importance of considering such effects when recording HRV metrics. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
期刊介绍:
Experimental and Clinical Psychopharmacology publishes advances in translational and interdisciplinary research on psychopharmacology, broadly defined, and/or substance abuse.