Malia A Belnap, Dylan E Kirsch, Erica N Grodin, Lara A Ray
{"title":"在递进比例任务中,对酒精的主观反应预测了自我管理酒精的动机。","authors":"Malia A Belnap, Dylan E Kirsch, Erica N Grodin, Lara A Ray","doi":"10.1037/pha0000792","DOIUrl":null,"url":null,"abstract":"<p><p>Subjective responses to alcohol, which encompass the subjective feelings and experiences elicited by alcohol consumption, are important factors implicated in the etiology of alcohol use disorder. Previous human laboratory studies have investigated how subjective responses to priming doses of alcohol influence alcohol self-administration (SA) but have not accounted for responses throughout the task. The present study investigated how subjective responses to alcohol, measured at multiple time points during a progressive ratio SA task, impacted subsequent motivation to self-administer alcohol. Participants (<i>n</i> = 67; 36 male/31 female) who drank heavily completed a 120-min progressive ratio alcohol intravenous SA paradigm. Every 15 min, participants were breathalyzed and completed self-report questionnaires to measure alcohol-induced stimulation, sedation, alcohol wanting, alcohol liking, negative mood, and positive mood. Alcohol SA was indicated by an increase in breath alcohol concentration. Time-lagged subjective response outcomes were examined as predictors of subsequent SA using multilevel modeling. Sex and family history of alcohol-related problems were investigated as potential moderators of the impact of subjective response measures on SA. Higher levels of alcohol-induced stimulation, as well as wanting and liking alcohol, predicted increased SA of alcohol. An increase in time, as a proxy for task demand, predicted a decreased likelihood of subsequent SA and moderated the effect of liking on SA. Family history of alcohol-related problems moderated the impact of alcohol-induced wanting and negative mood on motivation to consume alcohol. Overall, these findings emphasize the significant role of subjective responses to alcohol, as well as their interactions with task demand and family history, in influencing alcohol consumption behaviors. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>","PeriodicalId":12089,"journal":{"name":"Experimental and clinical psychopharmacology","volume":" ","pages":"503-512"},"PeriodicalIF":2.2000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task.\",\"authors\":\"Malia A Belnap, Dylan E Kirsch, Erica N Grodin, Lara A Ray\",\"doi\":\"10.1037/pha0000792\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Subjective responses to alcohol, which encompass the subjective feelings and experiences elicited by alcohol consumption, are important factors implicated in the etiology of alcohol use disorder. Previous human laboratory studies have investigated how subjective responses to priming doses of alcohol influence alcohol self-administration (SA) but have not accounted for responses throughout the task. The present study investigated how subjective responses to alcohol, measured at multiple time points during a progressive ratio SA task, impacted subsequent motivation to self-administer alcohol. Participants (<i>n</i> = 67; 36 male/31 female) who drank heavily completed a 120-min progressive ratio alcohol intravenous SA paradigm. Every 15 min, participants were breathalyzed and completed self-report questionnaires to measure alcohol-induced stimulation, sedation, alcohol wanting, alcohol liking, negative mood, and positive mood. Alcohol SA was indicated by an increase in breath alcohol concentration. Time-lagged subjective response outcomes were examined as predictors of subsequent SA using multilevel modeling. Sex and family history of alcohol-related problems were investigated as potential moderators of the impact of subjective response measures on SA. Higher levels of alcohol-induced stimulation, as well as wanting and liking alcohol, predicted increased SA of alcohol. An increase in time, as a proxy for task demand, predicted a decreased likelihood of subsequent SA and moderated the effect of liking on SA. Family history of alcohol-related problems moderated the impact of alcohol-induced wanting and negative mood on motivation to consume alcohol. Overall, these findings emphasize the significant role of subjective responses to alcohol, as well as their interactions with task demand and family history, in influencing alcohol consumption behaviors. (PsycInfo Database Record (c) 2025 APA, all rights reserved).</p>\",\"PeriodicalId\":12089,\"journal\":{\"name\":\"Experimental and clinical psychopharmacology\",\"volume\":\" \",\"pages\":\"503-512\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental and clinical psychopharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1037/pha0000792\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental and clinical psychopharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1037/pha0000792","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/24 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
摘要
对酒精的主观反应,包括由酒精消费引起的主观感受和体验,是涉及酒精使用障碍病因学的重要因素。先前的人类实验室研究已经调查了对酒精启动剂量的主观反应如何影响酒精自我给药(SA),但没有考虑到整个任务的反应。本研究调查了在递进比例SA任务中多个时间点对酒精的主观反应如何影响随后的自我饮酒动机。参与者(n = 67;36名男性/31名女性)重度饮酒的患者完成了120分钟的递进比例酒精静脉注射SA模式。每隔15分钟,参与者进行呼吸测试并完成自我报告问卷,以测量酒精引起的刺激、镇静、酒精欲望、酒精喜好、消极情绪和积极情绪。呼气中酒精浓度的增加表明酒精SA。时间滞后的主观反应结果用多水平模型检验作为后续SA的预测因子。性别和酒精相关问题的家族史作为主观反应措施对SA影响的潜在调节因素进行了调查。更高水平的酒精刺激,以及想要和喜欢酒精,预示着酒精的SA增加。时间的增加,作为任务需求的代理,预测了后续SA的可能性降低,并缓和了喜欢对SA的影响。酒精相关问题的家族史缓和了酒精引起的欲望和消极情绪对饮酒动机的影响。总的来说,这些发现强调了对酒精的主观反应,以及它们与任务需求和家族史的相互作用,在影响酒精消费行为方面的重要作用。(PsycInfo Database Record (c) 2025 APA,版权所有)。
Subjective response to alcohol predicts motivation to self-administer alcohol in a progressive ratio task.
Subjective responses to alcohol, which encompass the subjective feelings and experiences elicited by alcohol consumption, are important factors implicated in the etiology of alcohol use disorder. Previous human laboratory studies have investigated how subjective responses to priming doses of alcohol influence alcohol self-administration (SA) but have not accounted for responses throughout the task. The present study investigated how subjective responses to alcohol, measured at multiple time points during a progressive ratio SA task, impacted subsequent motivation to self-administer alcohol. Participants (n = 67; 36 male/31 female) who drank heavily completed a 120-min progressive ratio alcohol intravenous SA paradigm. Every 15 min, participants were breathalyzed and completed self-report questionnaires to measure alcohol-induced stimulation, sedation, alcohol wanting, alcohol liking, negative mood, and positive mood. Alcohol SA was indicated by an increase in breath alcohol concentration. Time-lagged subjective response outcomes were examined as predictors of subsequent SA using multilevel modeling. Sex and family history of alcohol-related problems were investigated as potential moderators of the impact of subjective response measures on SA. Higher levels of alcohol-induced stimulation, as well as wanting and liking alcohol, predicted increased SA of alcohol. An increase in time, as a proxy for task demand, predicted a decreased likelihood of subsequent SA and moderated the effect of liking on SA. Family history of alcohol-related problems moderated the impact of alcohol-induced wanting and negative mood on motivation to consume alcohol. Overall, these findings emphasize the significant role of subjective responses to alcohol, as well as their interactions with task demand and family history, in influencing alcohol consumption behaviors. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
期刊介绍:
Experimental and Clinical Psychopharmacology publishes advances in translational and interdisciplinary research on psychopharmacology, broadly defined, and/or substance abuse.