口服尼古丁袋对无烟烟草使用者的生理和主观影响。

IF 2.2 3区 医学 Q3 PHARMACOLOGY & PHARMACY
Experimental and clinical psychopharmacology Pub Date : 2025-10-01 Epub Date: 2025-08-21 DOI:10.1037/pha0000798
Alisha Eversole, Rabia Imran, Nicoleta Gaitan, Caroline O Cobb, Andrew J Barnes, Matthew Halquist, Rashelle B Hayes, Thokozeni Lipato, Thomas Eissenberg, Alison Breland
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引用次数: 0

摘要

尼古丁袋(NPs)不含烟叶,而是充满尼古丁粉末,调味剂和pH调节剂。关于NPs影响的独立(即非工业资助/附属)研究很少。这项独立于行业的研究的目的是检验NP对使用无烟烟草(SLT)的人的影响。24名参与者完成了四个疗程,包括三个NP条件(2,4和8毫克标记的总尼古丁含量;“on!”品牌,奥特里亚,里士满,弗吉尼亚)和参与者自己的品牌(OB) SLT。参与者完成两次每次30分钟的给药,结果包括血浆尼古丁浓度以及主观和行为经济指标。结果表明,8mg NP与OB在生理和主观测量方面没有显著差异;在某些测量中,4mg NP与OB和8mg NP不同,与OB和8mg NP相比,2mg NP确实提供更少的尼古丁和减少戒断症状的效果更差。研究结果初步支持了高尼古丁含量的NPs可以替代定期使用SLT的人的SLT,而低尼古丁含量的NPs则不能。总体而言,标记尼古丁含量影响“on!”牌NP的尼古丁传递和戒断症状抑制,在评估NP法规对个人和公众健康的影响时应考虑尼古丁含量和传递。(PsycInfo Database Record (c) 2025 APA,版权所有)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Physiological and subjective effects of an oral nicotine pouch in people who use smokeless tobacco.

Nicotine pouches (NPs) contain no tobacco leaf but instead are filled with nicotine powder, flavorants, and pH adjusters. There are very few independent (i.e., non-industry-funded/affiliated) studies regarding the effects of NPs. The purpose of this industry-independent study is to examine NP effects in people who use smokeless tobacco (SLT). Twenty-four participants completed four sessions that included three NP conditions (2, 4, and 8 mg labeled total nicotine content; "on!" brand, Altria, Richmond, Virginia) and participants' own brand (OB) SLT. Participants completed two 30-min administration periods per session, and outcomes included plasma nicotine concentration as well as subjective and behavioral economic measures. Results indicate that the 8 mg NP did not differ significantly from OB across physiological and subjective measures; the 4 mg NP differed from OB and 8 mg on some measures, and the 2 mg NP reliably delivered less nicotine and reduced abstinence symptoms less effectively when compared to OB and the 8 mg NP. Study results offer preliminary support for the notion that higher nicotine content NPs may substitute for SLT in people who use SLT regularly, while lower nicotine content NPs may not. Overall, labeled nicotine content influences the nicotine delivery and abstinence symptom suppression of "on!" brand NP, and nicotine content and delivery should be considered when assessing the individual and public health impact of NP regulations. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

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来源期刊
CiteScore
4.20
自引率
8.70%
发文量
164
审稿时长
6-12 weeks
期刊介绍: Experimental and Clinical Psychopharmacology publishes advances in translational and interdisciplinary research on psychopharmacology, broadly defined, and/or substance abuse.
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