European Journal of Psychiatry最新文献

{"title":"Duration of anorexia nervosa is positively associated with whole blood mitochondrial DNA copy number: A cross-sectional case-control study","authors":"Eimear Doody ,&nbsp;Karen M. Ryan ,&nbsp;Clare O'Toole ,&nbsp;Declan M. McLoughlin","doi":"10.1016/j.ejpsy.2024.100265","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100265","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>Anorexia nervosa (AN) is associated with significant physical and psychological stress. Stress causes changes at a cellular level and mitochondria may reflect this stress via changes such as alterations in DNA quantity or in their function. Mitochondria are unique in that they possess their own DNA, distinct from nuclear DNA, of which there are many copies within the cell. An indirect measure of mitochondrial function is the assessment of mitochondrial DNA copy number (mtDNAcn). Telomere length (TL) represents a marker of normal biological ageing, and TL can be shortened by stressors. We sought to test the following hypotheses: (1) that increased mtDNAcn would be found in patients with AN in comparison to healthy controls, (2) that mtDNAcn is related to duration and severity of AN, and (3) mtDNAcn is correlated with TL.</p></div><div><h3>Methods</h3><p>Using quantitative real-time polymerase chain reaction, we calculated mtDNAcn and TL using peripheral whole blood DNA collected from patients with AN (<em>n</em> = 23) compared to samples from age- and sex-matched healthy controls (<em>n</em> = 33). Clinical characteristics were also obtained.</p></div><div><h3>Results</h3><p>We found no difference between mtDNAcn in patients with AN in comparison to controls. mtDNAcn was positively associated with duration of illness, but not with illness severity. There was no association between mtDNAcn and TL.</p></div><div><h3>Conclusions</h3><p>Further investigations may clarify whether compensatory mechanisms increase mtDNAcn with increased illness duration.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 4","pages":"Article 100265"},"PeriodicalIF":2.5,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213616324000156/pdfft?md5=5945ce392f334f5eb4b09d004f1f8f3d&pid=1-s2.0-S0213616324000156-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of COVID-19 on mental health of pregnant women: Does timing of infection matter?","authors":"Sara Barrio-Martínez ,&nbsp;Nancy Murillo-García ,&nbsp;Margarita Miguel-Corredera ,&nbsp;Víctor Ortiz-García de la Foz ,&nbsp;Alejandra Sanz-Sanz ,&nbsp;Rosa Ayesa-Arriola","doi":"10.1016/j.ejpsy.2024.100269","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100269","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>This study aimed to examine sociodemographic and clinical characteristics between pregnant women infected (cases) and non-infected (controls) with COVID-19 and their offspring, focusing on the trimester in which the infection occurred</p></div><div><h3>Methods</h3><p>A total of 115 mother-infant dyads (64 cases and 51 controls), were analysed to evaluate maternal, delivery and new-borns’ characteristics. In particular, anxiety and depressive symptoms, sleep satisfaction, perinatal stress, bonding, social support or fear of COVID-19, during pregnancy and 6-weeks after delivery were explored. Student's <em>t</em>-test, chi-square and repeated measure analysis of variance were used for comparisons when appropriate</p></div><div><h3>Results</h3><p>No significant differences were observed between the two groups in any of the variables analysed, except for the mothers’ education, which was higher in the control group. Regarding the timing of infection, those who were infected during the first trimester reported lower levels of perceived social support and higher levels of anxiety</p></div><div><h3>Conclusions</h3><p>These findings suggest that the emotional impact of the pandemic may be similar throughout the population, regardless of infection status. However, the impact of the COVID-19 on mental health of future mothers appears to be more significant during the early stages of pregnancy. These results underscore the relevance of providing adequate support from the early stages of pregnancy, in order to enhance women well-being.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 4","pages":"Article 100269"},"PeriodicalIF":2.5,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Love addiction: Trait impulsivity, emotional dysregulation and attachment style","authors":"Jessica Dineen,&nbsp;Linda Dinc","doi":"10.1016/j.ejpsy.2024.100255","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100255","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>Growing attention has been given in the last few years to psychological predictors of love addiction (LA)<span>¹</span> broadening the understanding of developing effective therapeutic measures. Emotional dysregulation, attachment style and trait impulsivity were examined in this study.</p></div><div><h3>Methods</h3><p>Participants (<em>N</em> = 249) completed a survey assessing the predictors of LA: impulsivity, emotional dysregulation, attachment styles and the Love Addiction Inventory Short Form<span>²</span> (LAI-SF).</p></div><div><h3>Results</h3><p>Regression analyses indicated that negative urgency (NU), anxious attachment, and emotional dysregulation (impulse) all significantly predicted LA (<em>p</em> &lt; 0.001). Moreover, impulse moderated the relationship between LA and negative urgency (NU).<span>³</span></p></div><div><h3>Conclusions</h3><p>Further qualitative research is suggested to provide a richer picture to the current findings and the use of neural correlates to ascertain the neuro-biological basis of LA. The present findings may inform treatment plans and suggests the use of psychotherapy to identify indicators of potential LA, manage emotions and to avoid addiction replacement.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100255"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex differences in changes in prolactin levels and sexual function after switching from risperidone to paliperidone palmitate in schizophrenia","authors":"Meritxell Tost ,&nbsp;Juan David Barbero ,&nbsp;Itziar Montalvo ,&nbsp;Alexandre González-Rodríguez ,&nbsp;Raquel Aguayo ,&nbsp;Aida Álvarez ,&nbsp;Rosa Gabernet ,&nbsp;Eduard Izquierdo ,&nbsp;Igor Merodio ,&nbsp;Siddarta Acebillo ,&nbsp;Diego Palao ,&nbsp;Javier Labad","doi":"10.1016/j.ejpsy.2024.100259","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100259","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Hyperprolactinaemia is a significant side effect of antipsychotic medications and may cause sexual dysfunction. Although risperidone and paliperidone can induce prolactin elevation, previous studies suggest that switching from risperidone long-acting injectable (LAI) to paliperidone palmitate (PP) might reduce prolactin concentrations in early psychosis patients. We aimed to evaluate the effect of switching from risperidone to PP on sexual functionality and prolactin levels in patients with schizophrenia.</p></div><div><h3>Methods</h3><p>We studied 38 patients with schizophrenia who were treated with risperidone (oral or R-LAI) monotherapy at stable doses for at least two months and had an indication to be switched to PP by their psychiatrists. Three assessments were completed: 1) baseline (preswitch), 2) 3 months post-switch, and 3) 6 months post-switch. Prolactin concentrations in plasma were determined. Sexual functioning was assessed with the Arizona Sexual Experience Scale (ASEX). Statistical analyses were conducted in 27 patients who had at least one follow-up visit. Longitudinal changes in prolactin levels and sexual function after switching from risperidone to PP were analysed with linear mixed models. Significance was set at <em>p</em> &lt; 0.05.</p></div><div><h3>Results</h3><p>Prolactin concentrations were reduced in women after the switch, with a significant time by sex effect (<em>p</em> = 0.035). Antipsychotic doses influenced prolactin levels (<em>p</em> = 0.006), such that higher antipsychotic doses were associated with higher prolactin concentrations. No significant differences were found in ASEX total scores at 6 months after the switch.</p></div><div><h3>Conclusions</h3><p>In patients with schizophrenia, switching from risperidone to PP was associated with a reduction in prolactin concentrations in women but not men.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100259"},"PeriodicalIF":1.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140816443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between dietary niacin intake and cognitive impairment in elderly people: A cross-sectional study","authors":"Kai Zhang ,&nbsp;Yu Han ,&nbsp;Fangming Gu ,&nbsp;Zhaoxuan Gu ,&nbsp;JiaYu Zhao ,&nbsp;Jianguo Chen ,&nbsp;Bowen Chen ,&nbsp;Min Gao ,&nbsp;Zhengyan Hou ,&nbsp;Xiaoqi Yu ,&nbsp;Tianyi Cai ,&nbsp;Yafang Gao ,&nbsp;Rui Hu ,&nbsp;Jinyu Xie ,&nbsp;Bo Li ,&nbsp;Tianzhou Liu","doi":"10.1016/j.ejpsy.2023.100233","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100233","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The presence of substantial evidence regarding the association between dietary niacin intake and cognitive impairment among the elderly remains limited, with inconsistent findings. Thus, the objective of this study was to assess the aforementioned relationship, utilizing data obtained from the National Health and Nutrition Examination Survey (NHANES).</p></div><div><h3>Methods</h3><p>This cross-sectional study analyzed 2255 participants aged ≥60 years from NHANES 2011–2014.The assessment of dietary niacin intake was conducted through two 24-hour dietary recalls, while cognitive function was evaluated using a battery of five tests. Multivariable logistic regression models and generalized additive model (GAM) was utilized to investigate the association between dietary niacin intake and cognitive impairment. Furthermore, subgroup analysis was conducted to assess the robustness of the primary findings.</p></div><div><h3>Results</h3><p>A total of 2255 old adults were included in this study, of whom 47.9% were male. In the fully adjusted model, we observed a significant inverse association between dietary niacin intake and cognitive decline [as a quartile variable, Q4 vs. Q1, odds ratio (OR):0.5 and 95% confidence interval (CI): (0.35∼0.72), <em>p</em> &lt; 0.001; as a continuous variable, per 1 mg/day increment, OR (95%CI):0.97(0.95∼0.98), <em>p</em> &lt; 0.001].The smooth curve fitting results revealed that A linear relationship was found between niacin intake and cognitive impairment in elderly people. The results of the sensitivity analysis remained stable.</p></div><div><h3>Conclusions</h3><p>Dietary niacin intakes might be inversely associated with the prevalence of cognitive impairment. Further research is required to confirm this association.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100233"},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum GDNF levels as predictors of subjective cognitive complaints in male subjects with major depressive disorder","authors":"Pedro Borges de Souza ,&nbsp;Taiane de Azevedo Cardoso ,&nbsp;Thaise Campos Mondin ,&nbsp;Luciano Dias de Mattos Souza ,&nbsp;Ricardo Azevedo da Silva ,&nbsp;Andressa Schneider Lobato ,&nbsp;Miriam Haj Omar ,&nbsp;Jean Pierre Oses ,&nbsp;Carolina David Wiener ,&nbsp;Karen Jansen ,&nbsp;Fernanda Pedrotti Moreira","doi":"10.1016/j.ejpsy.2024.100258","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100258","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>Major Depressive Disorder (MDD) is characterized by cognitive dysfunction and neurotropic and inflammatory factors linked to its pathophysiology and cognitive impairment. This study aims to identify the prodromal serum biomarkers correlated to cognitive impairment in individuals diagnosed with MDD, including variation between sexes.</p></div><div><h3>Methods</h3><p>This study is part of a larger two-stage research. The initial stage involved the sample of participants aged between 18 and 60 years old, diagnosed with MDD. The second phase took place three years later. The baseline assessments included a biomarker blood test (BDNF, GDNF, NGF, IL-6 and TNF-α). Follow-up assessments used the Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) for subjective cognition and the number-letter sequence of the Wechsler Adult Intelligence Scale (WAIS-III) for objective cognition.</p></div><div><h3>Results</h3><p>The sample consisted of 155 subjects, 30 males and 125 females. In the sex-stratified sample, a correlation was found between COBRA and GDNF biomarkers in males (<em>r</em>= -0.339; <em>p</em> = 0.039). When COBRA was applied as a dependent variable in the multiple linear regression, the overall model was significant (Z (9, 50) = 2.611, <em>p</em> = 0.032; adjusted R² = 0.620), with the highest impact on sex (β = 0.442, <em>p</em> = 0.003, p_adjFDR = 0.019), symptom severity (β = 0.605, <em>p</em> &lt; 0.001, p_adjFDR = 0.013) and GDNF levels (β = -0.414, <em>p</em> = 0.005, p_adjFDR = 0.021).</p></div><div><h3>Conclusions</h3><p>Our results suggest that GDNF might be a prodromal biomarker for the early detection of subjective cognitive complaints only when targeting males with MDD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 4","pages":"Article 100258"},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in the therapeutic response to lifestyle improvement-based interventions for treatment-resistant depression","authors":"Alejandra Aguilar-Latorre ,&nbsp;Margalida Gili ,&nbsp;Capilla Navarro-Guzmán ,&nbsp;Aurora Garcia ,&nbsp;Aina M. Yáñez ,&nbsp;Mauro Garcia-Toro","doi":"10.1016/j.ejpsy.2024.100254","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100254","url":null,"abstract":"<div><p>Treatment-resistant depression (TRD) poses a significant societal challenge, with gender-specific treatment gaps. In a clinical trial targeting TRD, we introduced lifestyle-based interventions. Analyzing data from 24 men and 70 women with TRD, the current study aimed to assess gender-related efficacy differences. Descriptive and univariate analyses unveiled variations in sociodemographic and clinical factors. Utilizing repeated measures ANOVA while controlling for baseline values and age, results indicated a notable gender disparity. Specifically, women exhibited a significantly poorer progression of depressive symptoms. This underscores the need for tailored interventions addressing gender-specific nuances in TRD treatment.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100254"},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213616324000053/pdfft?md5=1488d1263e74d3dea105a679b4e8fef7&pid=1-s2.0-S0213616324000053-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The new long-acting injectable for maintenance treatment of schizophrenia: What is the clinical value of aripiprazole 2-month ready-to-use 960 mg?","authors":"Cecilio Álamo ,&nbsp;Ana Catalán ,&nbsp;David Fraguas ,&nbsp;Francisco Gotor ,&nbsp;Javier Labad ,&nbsp;Carlos Parro-Torres ,&nbsp;Víctor Pérez ,&nbsp;Pilar Sierra","doi":"10.1016/j.ejpsy.2024.100260","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100260","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100260"},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do depressed people with subjective psychomotor retardation show a different symptomatic pattern? A network analysis approach using a cross-national sample","authors":"Javier Gómez-Cumplido ,&nbsp;Ana Izquierdo ,&nbsp;Beata Tobiasz-Adamczyk ,&nbsp;Seppo Koskinen ,&nbsp;Josep María Haro ,&nbsp;José Luis Ayuso-Mateos ,&nbsp;María Cabello","doi":"10.1016/j.ejpsy.2024.100253","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100253","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Psychomotor retardation (PMR) has been associated with worse clinical course in depressed people. Explanations for this finding remain inconclusive. This study aimed to analyse whether depressed people with subjective PMR might show a different symptomatic pattern and to describe their clinical and sociodemographic profiles.</p></div><div><h3>Methods</h3><p>A total of 1024 participants from Finland, Spain and Poland, part of the “COURAGE in Europe” Project who screened positive for a depressive episode according to International Classification of Diseases-10 (ICD-10) criteria using the World Health Organization Composite International Diagnostic Interview 3.0 (CIDI 3.0), were included. Two group networks of depressive symptoms were estimated according to the presence (555 people) and absence (469 people) of subjective PMR. Measures of strength and betweenness of depressive symptoms were explored.</p></div><div><h3>Results</h3><p>People with subjective PMR showed a higher number of symptoms (11.30 (±2.67) versus 9.26 (±2.77)) and global disability score (38.30 (±26.41) versus 19.59 (±19.31) than people without subjective PMR. Although no difference was found in the global structure (M-Test=1.531; <em>p</em> = 0.994) nor the global strength (S-Test=0.248; <em>p</em> = 0.954) of depressed symptoms between depressed people with and without subjective PMR, differences were found in the type of central symptoms; “Restlessness/Jitters” (<em>p</em> = 0.01) and “Early Wake-Up” (<em>p</em> = 0.02) were relevant for the subjective PMR group. These two symptoms worked as bridge items between other depressive symptoms specifically for depressed people with subjective PMR.</p></div><div><h3>Conclusions</h3><p>Our results confirm that subjective PMR in depression is associated with higher severity of symptoms and disability. Depressed People with subjective PMR might show a different pattern of nuclear symptoms. Suicidal attempt, early wake-up and restlessness could be high-priority targets in the treatment of depressed people with subjective PMR.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100253"},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clock drawing test with convolutional neural networks to discriminate mild cognitive impairment","authors":"Jin-Hyuck Park","doi":"10.1016/j.ejpsy.2024.100256","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2024.100256","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The Clock Drawing Test (CDT) is a tool to assess cognitive function. Despite its usefulness, its interpretation remains challenging, leading to a low reliability. The main objective of this study was to determine the feasibility of using the CDT with convolutional neural networks (CNNs) as a screening tool for amnestic type of mild cognitive impairment (a-MCI).</p></div><div><h3>Methods</h3><p>A total of 177 CDT images were obtained from 103 healthy controls (HCs) and 74 patients with a-MCI. CNNs were trained to classify MCI based on the CDT images. To evaluate the performance of the CDT with CNNs, accuracy, sensitivity, specificity, precision, and f1-score were calculated. To compare discriminant power, the area under the curve of the CDT with CNNs and the Korean version of the Montreal Cognitive Assessment (MoCA-K) was calculated by the receiving operating characteristic curve analysis.</p></div><div><h3>Results</h3><p>The CDT with CNNs was more accurate in discriminating a-MCI (CDT with CNNs = 88.7%, MoCA-<em>K</em> = 81.8%). Furthermore, the CDT with CNNs could better discriminate a-MCI than the MoCA-K (AUC: CDT with CNNs = 0.886, MoCA-<em>K</em> = 0.848).</p></div><div><h3>Conclusion</h3><p>These results demonstrate the superiority of the CDT with CNNs to the MoCA-K for distinguishing a-MCI from HCs. The CDT with CNNs could be a surrogate for a conventional screening tool for a-MCI.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 3","pages":"Article 100256"},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140813306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}