European Journal of Psychiatry最新文献

{"title":"Depression and multimorbidity - Results from a nationwide study","authors":"Bárbara Pedrosa ,&nbsp;Mariana Neto ,&nbsp;Sónia Namorado ,&nbsp;Andreia Leite","doi":"10.1016/j.ejpsy.2022.09.004","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.09.004","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Most studies concerning the relationship between depression and chronic physical disease focused on a single physical disease and did not consider multimorbidity or depression severity. We aimed to characterize this relationship considering chronic physical diseases’ type and number, and depression severity.</p></div><div><h3>Methods</h3><p>We undertook a cross-sectional study, using data from a phone household panel, with “chronic physical disease” as the exposure and “depression” as the outcome. The sample is representative of the Portuguese population. Adjusted logistic and multinomial regression analyses were conducted between depression presence/severity and chronic physical disease presence/type/number. Odds ratio and 95% confidence intervals adjusted for possible confounders were calculated.</p></div><div><h3>Results</h3><p>1027 individuals were included. Of the population, 8.9% had depression and 72.1% had at least one chronic physical disease. There was no statistically significant relationship between depression and physical disease in general (OR=1.68 [CI95%:0.55, 5.15]), but there was with allergy (OR=2.08 [CI95%:1.02, 4.25]) and COPD (OR=3.04 [CI95%:1.21, 7.61]). The risk of depression was smaller with two physical diseases (vs. three or more, OR=0.32 [CI95%:0.15, 0.68]).</p></div><div><h3>Conclusions</h3><p>A relationship between COPD, allergy and a higher number of physical diseases and depression was observed. Clinicians should be aware of these relationships. Evaluating the presence of depression in people with multimorbidity, COPD and allergy is recommended.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 2","pages":"Pages 92-99"},"PeriodicalIF":1.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The network structure of self-reported psychopathological dimensions in common mental disorders (CMDs)","authors":"Manuel J. Cuesta ,&nbsp;Juan I. Arrarás ,&nbsp;Gustavo J. Gil-Berrozpe ,&nbsp;Victor Peralta ,&nbsp;Laura Barrado ,&nbsp;Olga Correa ,&nbsp;Rebeca Elorza ,&nbsp;Lorea Fernández ,&nbsp;Irma Garmendia ,&nbsp;Lucía Janda ,&nbsp;Patricia Macaya ,&nbsp;Camino Núñez ,&nbsp;Pablo Sabater ,&nbsp;Aileen Torrejon","doi":"10.1016/j.ejpsy.2022.11.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.11.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Common mental disorders (CMDs) in mental health settings show high rates of comorbidities. While semi-structured interviews are the gold standard to establish a diagnosis, there are self-report instruments such as the Psychiatric Diagnostic Screening Questionnaire (PDSQ) that aids clinicians in improving the diagnostic process in a time-efficient manner.</p></div><div><h3>Methods</h3><p>Network analysis of the 13 domains of the PDSQ was applied to a sample of 374 first-contact outpatients to identify domains of psychopathology acting as hubs and bridges of interconnections within the CMDs.</p></div><div><h3>Results</h3><p>A global network densely connected with positive connections among PDSQ domains was found. The global network has four main clusters: depression-anxiety, somatoform, psychosis and substance-related domains. This network allowed for the identification of main ‘nodes’ acting as hubs favoring interconnections between dimensions and main ‘bridges’ easing the connections between clusters.</p></div><div><h3>Conclusion</h3><p>The network structure of the PDSQ domains might provide a complementary explanation to the high rates of comorbidity among CMDs. Moreover, our results support the relevance of the self-administered PDSQ inventory to account for a deeper understanding of comorbidities among CMDs.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 2","pages":"Pages 100-108"},"PeriodicalIF":1.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 perceived stigma among survivors: A cross-sectional study of prevalence and predictors","authors":"Mohamad Alchawa ,&nbsp;Sarah Naja ,&nbsp;Khaled Ali ,&nbsp;Vahe Kehyayan ,&nbsp;Peter Michael Haddad ,&nbsp;Iheb Bougmiza","doi":"10.1016/j.ejpsy.2022.08.004","DOIUrl":"10.1016/j.ejpsy.2022.08.004","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Perceived stigma related to infectious diseases is of public health importance and can adversely impact patients' physical and mental health. This study aims to identify the level of perceived stigma among COVID-19 survivors in Qatar and investigate its predictors.</p></div><div><h3>Methods</h3><p>An analytical cross-sectional design was employed. Four hundred and four participants who had a positive COVID-19 PCR test were randomly selected from medical records. The selected participants were interviewed to collect sociodemographic and health-related information. Perceived stigma was assessed using the COVID-19 perceived stigma scale-22 (CPSS-22) that was developed by the researchers. A descriptive analysis followed by a bivariate analysis investigated possible associations between the perceived stigma levels and independent variables. A multivariable analysis was performed using logistic regression to identify any significant associations with perceived stigma. The validity and reliability of the developed tool were also tested.</p></div><div><h3>Results</h3><p>The prevalence of COVID-19 perceived stigma was twenty-six percent (<em>n</em> = 107, 26.4%) at 95% CI [22.4–30.4]. Factors associated with higher COVID-19 perceived stigma were male gender, being a manual worker, non-Arabic ethnicity, low educational level, living alone, and being isolated outside the home. However, only occupation, ethnicity, and low educational level predicted COVID-19 perceived stigma in multivariable analysis. The CPSS-22 showed excellent reliability (Cronbach's alpha 0.92).</p></div><div><h3>Conclusion</h3><p>Perceived stigma was relatively common among participants. Designing programs and interventions targeting male manual workers and those of low-educational levels may assist policymakers in mitigating the stigma related to COVID-19.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 24-35"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9424513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10830437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between objective and subjective cognitive performance to clinical features in bipolar disorder: A 6 years follow-up study","authors":"Leticia Sanguinetti Czepielewski ,&nbsp;Marcia Kauer-Sant'Anna ,&nbsp;Flavio Kapczinski ,&nbsp;Joana Bücker","doi":"10.1016/j.ejpsy.2022.07.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.07.001","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 63-66"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMT rs4680 and DRD2 rs6275 variants and their association with YMRS scores in children with early-onset bipolar disorder","authors":"M. Cengiz ,&nbsp;G. Karacetin ,&nbsp;M. Topal ,&nbsp;M.E. Yuksel ,&nbsp;T. Eseroglu ,&nbsp;G.B. Akdeniz ,&nbsp;T. Demir ,&nbsp;M. Erkiran ,&nbsp;A. Dirican ,&nbsp;B. Bayoglu","doi":"10.1016/j.ejpsy.2022.07.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.07.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span><span>Bipolar disorder (BD) is a clinical status with at least one manic, hypomanic or mixed attacks. </span>Genetic factors<span> take part significantly in early-onset BD (EOBD). Dopamine receptors (DRD) act in neurological mechanisms like motivation, learning, memory, and, control of neuroendocrine signaling. DRD2 receptor has been reported to influence the stability of </span></span><em>DRD2</em><span> transcript. Catechol-O-Methyl transferase (COMT) inactivates catecholamines and Val158Met variation on </span><em>COMT</em> has effects on COMT activity. This study aims to explore <em>DRD2</em> and <em>COMT</em> variants in the clinical development of EOBD.</p></div><div><h3>Methods</h3><p>In this case-control study, 102 EOBD patients and 168 healthy control subjects were used. <em>DRD2</em> rs6275 and <em>COMT</em><span> Val158Met variations were detected by real-time polymerase chain reaction (RT-PCR). Young Mania Rating Scale (YMRS) was utilized to determine the EOBD severity.</span></p></div><div><h3>Results</h3><p>For <em>DRD2</em> rs6275 and <em>COMT</em> Val158Met polymorphisms, no significant relationship was observed in the genotype and allele frequencies between patient and control groups. Nevertheless, TT genotype carriers of <em>DRD2</em> rs6275 polymorphism demonstrated significantly increased YMRS scores when compared with CC and CT genotype carriers (<em>p</em> = 0.039). Nevertheless, no significant difference was observed between <em>COMT</em> Val158Met genotypes and YMRS scores.</p></div><div><h3>Conclusions</h3><p>We suggest that the <em>DRD2</em><span> rs6275 TT variant can be associated with symptom severity in children with EOBD and can have a clinical significance in EOBD pathogenesis. However, these results need to be confirmed with larger samples of patient and control groups.</span></p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 8-14"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive symptoms associated with left temporal dysembryoplastic neuroepithelial tumor: A case report","authors":"Ritwik Ghosh ,&nbsp;Abhiram Narasimhan Purohith ,&nbsp;G. Lakshmi Prasad ,&nbsp;Rashmi Appaji ,&nbsp;Sonia Shenoy","doi":"10.1016/j.ejpsy.2022.09.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.09.001","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 69-70"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum brain-derived neurotrophic factor levels in depression with and without melancholy and in healthy participants","authors":"Reiji Yoshimura,&nbsp;Naomichi Okamoto,&nbsp;Atsuko Ikenouchi","doi":"10.1016/j.ejpsy.2022.08.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.08.002","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 67-68"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients","authors":"Hong-tao Song ,&nbsp;Xin-yang Sun ,&nbsp;Wei Niu ,&nbsp;Qiao-li Zhang ,&nbsp;Li-yi Zhang ,&nbsp;Ai-fang Zhong","doi":"10.1016/j.ejpsy.2022.09.005","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.09.005","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and </span>major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.</p></div><div><h3>Methods</h3><p>Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale<span> (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology<span> assessments before and after three weeks of treatment.</span></span></p></div><div><h3>Results</h3><p>The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (<em>P &lt;</em> 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (<em>P &lt;</em> 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (<em>P &lt;</em> 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (<em>P &lt;</em> 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (<em>p &lt;</em> 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (<em>P &lt;</em> 0.05).</p></div><div><h3>Conclusion</h3><p>MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 15-23"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study","authors":"Paweł Zagozdzon ,&nbsp;Piotr Dorozynski ,&nbsp;Przemysław Waszak ,&nbsp;Adam Harasimowicz ,&nbsp;Tomasz Dziubich","doi":"10.1016/j.ejpsy.2022.06.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.06.002","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The potential role of antipsychotics<span> in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine<span> and lithium, and drugs<span> for cardiometabolic diseases.</span></span></span></p></div><div><h3>Methods</h3><p>We conducted a retrospective longitudinal analysis involving 84,881 patients who received antipsychotics between 2008 and 2012. Data on deaths were collected from the National Death Registry. The sequence creation was performed according to an algorithm that iterates prescriptions in chronological order and appends them to the end of the patient's prescription sequence. Fuzzy set qualitative comparative analysis (FsQCA) was also used to produce causal combinations of conditions that best lead to survival.</p></div><div><h3>Results</h3><p>There were 1,095,518 antipsychotic prescriptions and 16,010 deaths among antipsychotic users. Among the reimbursement data, 85,272 drug sequences were identified. The most prevalent sequence consisted of FGA (69.1%). Subsequent groups consisted of FGA, followed by SGA (13.1%) and SGA-only (12.3%) sequences. The highest occurrence of death and cardiometabolic drug use after introducing antipsychotic treatment was observed for clozapine. The FsQCA analysis revealed the highest coverage for combinations of young age with FGA (40.6%) or with no cardiometabolic risk factors drug therapy (39.5%).</p></div><div><h3>Conclusion</h3><p>The sequence analysis suggests that clozapine is associated with an increased death risk compared to FGA and SGA.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 1-7"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients’ perspectives on telemedicine in the encounter between healthcare and patients with mental illness: A systematic review","authors":"Sally Wulff Jørgensen ,&nbsp;Kim Lee ,&nbsp;Søren Harnow Klausen ,&nbsp;Esben Nedenskov Petersen ,&nbsp;Birgitte Nørgaard","doi":"10.1016/j.ejpsy.2022.08.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.08.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p>This systematic review aimed to investigate the experiences and opinions of people with mental illness regarding the role of telemedicine in their treatment.</p></div><div><h3>Methods</h3><p>To be eligible, studies were required to include people between 18 and 65 years of age with mental illness, defined as depression, anxiety, bipolar disorder, schizophrenia, or personality disorder. It was further required that the patients’ experiences of the telehealth solutions were reported. Between April 5, 2020, and June 29, 2020 (renewed November 10, 2021), the CINAHL electronic database was searched. Using the OVID search engine, Embase, MEDLINE, and PsycINFO were likewise searched; gray literature was retrieved from Scopus. The included studies were critically appraised using the CASP checklists.</p></div><div><h3>Results</h3><p>Seventeen studies were included. Treatment provided via telehealth technology offered people with mental illness insights and skills that helped them cope better in everyday life. The patient—therapist relationship was improved where the parties collaborated. Furthermore, gaining control of one's mental health by using an app and following one's development empowered people with mental illness, leading to greater involvement in treatment.</p></div><div><h3>Conclusions</h3><p>Engaging people with mental illness in decisions concerning the use of telehealth technology is essential. It is likewise important that both people with mental illness and health professionals have access to help with the implementation of technology, and that telehealth solutions function as a supplement rather than a substitute for face-to-face treatment.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 44-62"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}