European Journal of Psychiatry最新文献

{"title":"The relationship between objective and subjective cognitive performance to clinical features in bipolar disorder: A 6 years follow-up study","authors":"Leticia Sanguinetti Czepielewski , Marcia Kauer-Sant'Anna , Flavio Kapczinski , Joana Bücker","doi":"10.1016/j.ejpsy.2022.07.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.07.001","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 63-66"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMT rs4680 and DRD2 rs6275 variants and their association with YMRS scores in children with early-onset bipolar disorder","authors":"M. Cengiz ,&nbsp;G. Karacetin ,&nbsp;M. Topal ,&nbsp;M.E. Yuksel ,&nbsp;T. Eseroglu ,&nbsp;G.B. Akdeniz ,&nbsp;T. Demir ,&nbsp;M. Erkiran ,&nbsp;A. Dirican ,&nbsp;B. Bayoglu","doi":"10.1016/j.ejpsy.2022.07.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.07.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span><span>Bipolar disorder (BD) is a clinical status with at least one manic, hypomanic or mixed attacks. </span>Genetic factors<span> take part significantly in early-onset BD (EOBD). Dopamine receptors (DRD) act in neurological mechanisms like motivation, learning, memory, and, control of neuroendocrine signaling. DRD2 receptor has been reported to influence the stability of </span></span><em>DRD2</em><span> transcript. Catechol-O-Methyl transferase (COMT) inactivates catecholamines and Val158Met variation on </span><em>COMT</em> has effects on COMT activity. This study aims to explore <em>DRD2</em> and <em>COMT</em> variants in the clinical development of EOBD.</p></div><div><h3>Methods</h3><p>In this case-control study, 102 EOBD patients and 168 healthy control subjects were used. <em>DRD2</em> rs6275 and <em>COMT</em><span> Val158Met variations were detected by real-time polymerase chain reaction (RT-PCR). Young Mania Rating Scale (YMRS) was utilized to determine the EOBD severity.</span></p></div><div><h3>Results</h3><p>For <em>DRD2</em> rs6275 and <em>COMT</em> Val158Met polymorphisms, no significant relationship was observed in the genotype and allele frequencies between patient and control groups. Nevertheless, TT genotype carriers of <em>DRD2</em> rs6275 polymorphism demonstrated significantly increased YMRS scores when compared with CC and CT genotype carriers (<em>p</em> = 0.039). Nevertheless, no significant difference was observed between <em>COMT</em> Val158Met genotypes and YMRS scores.</p></div><div><h3>Conclusions</h3><p>We suggest that the <em>DRD2</em><span> rs6275 TT variant can be associated with symptom severity in children with EOBD and can have a clinical significance in EOBD pathogenesis. However, these results need to be confirmed with larger samples of patient and control groups.</span></p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 8-14"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obsessive-compulsive symptoms associated with left temporal dysembryoplastic neuroepithelial tumor: A case report","authors":"Ritwik Ghosh ,&nbsp;Abhiram Narasimhan Purohith ,&nbsp;G. Lakshmi Prasad ,&nbsp;Rashmi Appaji ,&nbsp;Sonia Shenoy","doi":"10.1016/j.ejpsy.2022.09.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.09.001","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 69-70"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum brain-derived neurotrophic factor levels in depression with and without melancholy and in healthy participants","authors":"Reiji Yoshimura,&nbsp;Naomichi Okamoto,&nbsp;Atsuko Ikenouchi","doi":"10.1016/j.ejpsy.2022.08.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.08.002","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 67-68"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder patients","authors":"Hong-tao Song ,&nbsp;Xin-yang Sun ,&nbsp;Wei Niu ,&nbsp;Qiao-li Zhang ,&nbsp;Li-yi Zhang ,&nbsp;Ai-fang Zhong","doi":"10.1016/j.ejpsy.2022.09.005","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.09.005","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Despite the growing pieces of evidence on the relationship between the altered expression level of miRNAs and </span>major depressive disorder (MDD), few studies have focused on the relationship between the altered expression of miRNAs and the severity of depressive symptoms. This study aimed to investigate the relationship between the expression level of miRNA-4485 and the severity of depressive symptoms in major depressive disorder (MDD) patients.</p></div><div><h3>Methods</h3><p>Eighty MDD patients without antidepressants and 45 healthy controls were placed and tested for the expression level of miRNA-4485 using quantitative RT‒PCR. At the same time, the Hamilton Depression Scale<span> (HAMD) was used to assess depression symptoms for MDD patients. Twenty-nine out of 80 MDD patients were selected for miRNA expression level testing and symptomatology<span> assessments before and after three weeks of treatment.</span></span></p></div><div><h3>Results</h3><p>The expression level of miRNA-4485 in the MDD group was significantly overexpressed compared to that in healthy controls (<em>P &lt;</em> 0.05), and the expression level of miRNA-4485 in the higher HAMD group was also much higher than that in the lower HAMD group and healthy controls (<em>P &lt;</em> 0.05). The expression level of miRNA-4485 in MDD patients was negatively correlated with HAMD total score, anxiety/somatization, and bodyweight factor score (<em>P &lt;</em> 0.05), accounting for 9.4%, 12.4% and 5.7%, respectively. MiRNA-4485 significantly predicted MDD and the severity of depressive symptoms (<em>P &lt;</em> 0.05). Compared with that before treatment, the expression level of miRNA-4485 was significantly downregulated after treatment, while the patient's depressive symptoms were improved (<em>p &lt;</em> 0.05). The improvement in depressive symptoms was positively correlated with the downregulation of miRNA-4485, which could significantly predict the effects of antidepressant treatment on MDD (<em>P &lt;</em> 0.05).</p></div><div><h3>Conclusion</h3><p>MiRNA-4485, which is significantly related to depressive symptoms and its improvement, could be a valuable biomarker or drug target to predict MDD, the severity of depressive symptoms and the effects of antidepressant treatment on MDD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 15-23"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antipsychotic drug prescription sequence analysis in relation to death occurrence and cardiometabolic drug usage: A retrospective longitudinal study","authors":"Paweł Zagozdzon ,&nbsp;Piotr Dorozynski ,&nbsp;Przemysław Waszak ,&nbsp;Adam Harasimowicz ,&nbsp;Tomasz Dziubich","doi":"10.1016/j.ejpsy.2022.06.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.06.002","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The potential role of antipsychotics<span> in increasing cardiovascular risk of mortality is still debated. The aim of this study was to assess the death risk associated with sequences of first-generation antipsychotic (FGA) and second-generation antipsychotic (SGA) prescriptions, including clozapine<span> and lithium, and drugs<span> for cardiometabolic diseases.</span></span></span></p></div><div><h3>Methods</h3><p>We conducted a retrospective longitudinal analysis involving 84,881 patients who received antipsychotics between 2008 and 2012. Data on deaths were collected from the National Death Registry. The sequence creation was performed according to an algorithm that iterates prescriptions in chronological order and appends them to the end of the patient's prescription sequence. Fuzzy set qualitative comparative analysis (FsQCA) was also used to produce causal combinations of conditions that best lead to survival.</p></div><div><h3>Results</h3><p>There were 1,095,518 antipsychotic prescriptions and 16,010 deaths among antipsychotic users. Among the reimbursement data, 85,272 drug sequences were identified. The most prevalent sequence consisted of FGA (69.1%). Subsequent groups consisted of FGA, followed by SGA (13.1%) and SGA-only (12.3%) sequences. The highest occurrence of death and cardiometabolic drug use after introducing antipsychotic treatment was observed for clozapine. The FsQCA analysis revealed the highest coverage for combinations of young age with FGA (40.6%) or with no cardiometabolic risk factors drug therapy (39.5%).</p></div><div><h3>Conclusion</h3><p>The sequence analysis suggests that clozapine is associated with an increased death risk compared to FGA and SGA.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 1-7"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients’ perspectives on telemedicine in the encounter between healthcare and patients with mental illness: A systematic review","authors":"Sally Wulff Jørgensen ,&nbsp;Kim Lee ,&nbsp;Søren Harnow Klausen ,&nbsp;Esben Nedenskov Petersen ,&nbsp;Birgitte Nørgaard","doi":"10.1016/j.ejpsy.2022.08.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.08.003","url":null,"abstract":"<div><h3>Background and objectives</h3><p>This systematic review aimed to investigate the experiences and opinions of people with mental illness regarding the role of telemedicine in their treatment.</p></div><div><h3>Methods</h3><p>To be eligible, studies were required to include people between 18 and 65 years of age with mental illness, defined as depression, anxiety, bipolar disorder, schizophrenia, or personality disorder. It was further required that the patients’ experiences of the telehealth solutions were reported. Between April 5, 2020, and June 29, 2020 (renewed November 10, 2021), the CINAHL electronic database was searched. Using the OVID search engine, Embase, MEDLINE, and PsycINFO were likewise searched; gray literature was retrieved from Scopus. The included studies were critically appraised using the CASP checklists.</p></div><div><h3>Results</h3><p>Seventeen studies were included. Treatment provided via telehealth technology offered people with mental illness insights and skills that helped them cope better in everyday life. The patient—therapist relationship was improved where the parties collaborated. Furthermore, gaining control of one's mental health by using an app and following one's development empowered people with mental illness, leading to greater involvement in treatment.</p></div><div><h3>Conclusions</h3><p>Engaging people with mental illness in decisions concerning the use of telehealth technology is essential. It is likewise important that both people with mental illness and health professionals have access to help with the implementation of technology, and that telehealth solutions function as a supplement rather than a substitute for face-to-face treatment.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 44-62"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital mental health and employment - Lessons from the Australian experience","authors":"Sebastian Rosenberg ,&nbsp;Luis Salvador-Carulla ,&nbsp;Sue Lukersmith ,&nbsp;Nasser Bagheri ,&nbsp;The EMPOWER Consortium","doi":"10.1016/j.ejpsy.2022.08.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.08.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>This paper reviews Australia's take-up of digital mental health interventions, including some specific reference to their application in relation to employment. Use of these interventions in Australia was already significant. Under COVID-19 they have exploded. The Australian experience offers useful lessons for European and other countries, and these are summarised.</p></div><div><h3>Methods</h3><p>This paper presents a narrative review of key texts, resources, policies and reports, from government and other sources. It also presents data reflecting the take-up of digital mental health services and the employment of people with a mental illness in Australia.</p></div><div><h3>Results</h3><p>We present data showing the explosion in uptake of digital mental health services. There is very limited evidence about the impact of these services in improving employment outcomes for people with a mental illness in Australia. The Government has moved to make them a permanent feature of mental health care, in addition to traditional face-to-face care.</p></div><div><h3>Conclusion</h3><p>Key lessons emerge from the Australian experience, including the need for target clarity; the importance of blending digital services into broader frameworks of mental health care; the need for quality and safety standards to be developed and applied to digital services; and the need for better evaluation of the outcomes of digital interventions in the workplace.</p><p>The digital mental health genie is out of the bottle. New capacity for evaluation of the outcomes of digital mental health services is vital to ensure value and quality of such investments.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 1","pages":"Pages 36-43"},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived stigma and discrimination among persons with mood and anxiety disorders: Results from the WHO World Mental Health Survey Portugal","authors":"Ana Antunes ,&nbsp;Manuela Silva ,&nbsp;Sofia Azeredo-Lopes ,&nbsp;Graça Cardoso ,&nbsp;José Miguel Caldas-de-Almeida","doi":"10.1016/j.ejpsy.2022.06.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.06.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>The stigma attached to mental disorders remains a </span>public health challenge, represents an important barrier to healthcare and widens existing social inequalities.</p><p>This study aimed to characterize the association between perceived stigma and mental disorders. The two main objectives were to estimate the association between perceived stigma and 12-month anxiety and mood disorders, and to assess the factors associated with perceived stigma among persons with these mental disorders.</p></div><div><h3>Methods</h3><p>A nationally representative sample of the Portuguese population was used. Participants were Portuguese-speaking adults, aged 18 or above and residing in permanent dwellings in the country's mainland. The survey was administered by trained lay interviewers using a computer assisted personal interview (CAPI) on a face-to-face setting.</p></div><div><h3>Results</h3><p>The results showed a two-fold increase in the likelihood of experiencing stigma among individuals with 12-month anxiety and mood disorders, slightly higher in the latter, when compared with individuals without. Among the sub-sample with these mental disorders, participants retired (or others), with psychiatric comorbidity and with co-occurrence of psychiatric and physical disorders had higher odds of reporting perceived stigma.</p></div><div><h3>Conclusions</h3><p>The findings of this study highlight the need to consider stigma as a public health priority in Portugal and to develop policies to create awareness and promote the social inclusion of persons with mental disorders.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"36 4","pages":"Pages 280-287"},"PeriodicalIF":1.8,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71732011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Activity of energy, glutamate, and glutathione metabolism enzymes in blood cells of elderly patients with depression","authors":"Olga Savushkina ,&nbsp;Irina Boksha ,&nbsp;Tatyana Prokhorova ,&nbsp;Elena Tereshkina ,&nbsp;Tatyana Safarova ,&nbsp;Olga Yakovleva ,&nbsp;Vladimir Kornilov ,&nbsp;Elena Shipilova ,&nbsp;Elena Vorobyeva ,&nbsp;Gulnur Burbaeva","doi":"10.1016/j.ejpsy.2022.05.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.05.001","url":null,"abstract":"<div><p><span><span>Heterogeneity of depression in older adults is a challenge for the development of person-centered treatment<span>. To address this, we studied glutamate and </span></span>glutathione metabolism enzymes in blood cells in 53 older adult patients with depression and 20 controls. Patients with depression had decreased platelet glutathione-S-transferase and erythrocyte </span>glutathione reductase<span>. The biochemical and clinical data contributed to three clinical clusters that are not linked to the onset of depression or its duration but were related to anxiety, cerebrovascular and cardiovascular comorbidities, including parkinsonian features such as tremor, akathisia, and rigidity. These findings could aid person-centered diagnosis and outcomes and timely successful treatment(s) of depression in older adults.</span></p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"36 4","pages":"Pages 288-293"},"PeriodicalIF":1.8,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71732012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}