European Journal of Psychiatry最新文献

{"title":"Borderline personality disorder vs. mood disorders: clinical comparisons in young people treated within an “Early Intervention” service for first episode psychosis","authors":"Lorenzo Pelizza ,&nbsp;Emanuela Leuci ,&nbsp;Emanuela Quattrone ,&nbsp;Silvia Azzali ,&nbsp;Giuseppina Paulillo ,&nbsp;Simona Pupo ,&nbsp;Pietro Pellegrini ,&nbsp;Arianna Biancalani ,&nbsp;Lorenzo Gammino ,&nbsp;Marco Menchetti","doi":"10.1016/j.ejpsy.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.002","url":null,"abstract":"<div><h3>Background and Objective</h3><p>Borderline Personality Disorder (BPD) is under-investigated in First Episode Psychosis (FEP). BPD psychotic manifestations and mood changes are also difficult to differentiate from first episode affective psychosis. The aim of this study was to compare sociodemographic and clinical features between FEP patients with BPD vs. Bipolar Disorder<span> (BD) or Major Depressive Disorder (MDD) both at baseline and across a 2-year follow-up period.</span></p></div><div><h3>Methods</h3><p><span>224 FEP participants (49 with BPD, 93 with BD and 82 with MDD) completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome Scale (PANSS) and the </span>Global Assessment of Functioning<span> (GAF) scale. Psychiatric diagnosis was reformulated at the end of our follow-up. Inter-group comparisons were analyzed using the Kruskal-Wallis or the Chi-square test. A mixed-design ANOVA model was also performed to assess the temporal stability of clinical scores within and between the 3 subgroups.</span></p></div><div><h3>Results</h3><p>Compared to FEP/BD subjects at baseline, FEP/BPD patients showed higher depressive symptom severity and lower excitement severity. Compared to FEP/MDD at entry, they had a higher prevalence rate of substance abuse, a lower interpersonal impairment and a shorter DUP. Finally, they had a lower treatment response on HoNOS “Psychiatric Symptoms” subscale scores across the follow-up in comparison with both FEP/BD and FEP/MDD individuals.</p></div><div><h3>Conclusion</h3><p>BPD as categorical entity represents a FEP subgroup with specific clinical features and treatment response. Appropriate treatment guidelines for this FEP subgroup are thus needed.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100219"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic-like experiences in obsessive compulsive disorder","authors":"Ulaş Korkmaz ,&nbsp;Ahmet Rifat Şahin ,&nbsp;Ömer Böke ,&nbsp;Gökhan Sarısoy ,&nbsp;Aytül Karabekiroğlu ,&nbsp;Selçuk Özdin ,&nbsp;Hatice Özyıldız Güz","doi":"10.1016/j.ejpsy.2023.06.001","DOIUrl":"10.1016/j.ejpsy.2023.06.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The study aims to compare individuals diagnosed with obsessive-compulsive disorder (OCD) and healthy individuals in terms of psychosis-like experiences (PLEs) and investigate the relationship between PLEs and OCD severity.</p></div><div><h3>Methods</h3><p>Sociodemographic information form, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the positive dimension of Community Assessment of Psychic Experiences (CAPE-P), Hamilton Depression Rating Scale<span> (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A) were applied to 83 OCD patients and 83 healthy individuals. The 11th item of Y-BOCS (Y-BOCS-11) was used to evaluate the level of insight. The OCD group was compared with the healthy control group in terms of sociodemographic information and CAPE-P score. In the OCD group, mediation analyses were performed to evaluate the factors affecting the relationship between OCD severity and PLEs.</span></p></div><div><h3>Results</h3><p>The OCD group had higher CAPE-P scores than the healthy control group. CAPE-P scores were weakly correlated with Y-BOCS-11 and Y-BOCS total scores. It was found that the relationship between OCD severity and PLEs was mediated by poor insight; however, the scores of depression and anxiety did not.</p></div><div><h3>Conclusion</h3><p>The results show that the level of insight is a determinative factor for PLEs in OCD. The fact that PLEs are common in the OCD group and healthy individuals support the concept of the psychosis continuum. We emphasize that being aware of PLEs in OCD can provide new understandings of the phenomenon of OCD and psychosis.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100215"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75180039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between mental health problems and asthma among European school children","authors":"James Goldin ,&nbsp;Florence Bodeau-Livinec ,&nbsp;Dietmar Goelitz ,&nbsp;Adina Bitfoi ,&nbsp;Mauro Giovanni Carta ,&nbsp;Ceren Koç ,&nbsp;Sigita Lesinskiene ,&nbsp;Zlatka Mihova ,&nbsp;Roy Otten ,&nbsp;Viviane Kovess-Masfety","doi":"10.1016/j.ejpsy.2023.100223","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100223","url":null,"abstract":"<div><h3>Background and objectives</h3><p>To examine the prevalence of two ISAAC (International Study of Asthma and Allergies in Childhood) asthma indicators in 7 European countries and their relationship with mental health disorders in children 6–12 years.</p></div><div><h3>Methods</h3><p>A cross-sectional survey of 5712 school children aged<span> 6–12 years using a video Self-administered instrument: Dominic Interactive and the Strengths and Difficulties Questionnaire (SDQ) for parents and teachers. Asthma indicators were 12 month “Wheezing or whistling in the chest” (WWC) and “Severe Asthma” (SA) based on number of attacks of wheezing, sleep disturbance due to wheezing, and limits to speech.</span></p></div><div><h3>Results</h3><p>On average 7.31% of the children had WWC, from 15.09% in Turkey to 1.32% in Italy; SA 2.22% on average ranged from 4.78% in Turkey to 0% in Italy. Generalized Anxiety Disorder (GAD) from child self-reports was significantly associated with WWC and SA even after adjustment for covariates. Based on parent and teacher combined reports, emotional problems were found to have significant associations with 12-month WWC after adjustment, as well as “any problems” which summarized externalizing and internalizing disorders Emotional, hyperactivity, conduct disorders were not associated with SA.</p></div><div><h3>Conclusion</h3><p>Asthma indicators very much differ across countries. Asthma indicators are associated with childhood GAD. Childhood self-reported mental health seems more related to Asthma indicators than parents/teachers combined reports.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100223"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with metabolic syndrome","authors":"Jizhou Liu ,&nbsp;Yonglan Yang ,&nbsp;Yanjiang Zhang ,&nbsp;Haifeng Wang ,&nbsp;Wenjian Wei ,&nbsp;Xiaoe Lang ,&nbsp;Xiangyang Zhang","doi":"10.1016/j.ejpsy.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Patients with major depressive disorder (MDD) have high comorbidity with metabolic syndrome (MetS), although anxiety is prevalent comorbidity in MDD patients. However, there is no study on anxiety symptoms (AS) in MDD patients with MetS. Therefore, we aimed to identify the prevalence and risk factors of AS in patients with MetS who experienced a first-episode and drug naïve (FEDN) of MDD.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, 1718 FEDN of MDD outpatients with MetS were included. Sociodemographic data, clinical characteristics, suicidal attempts, and physical and biochemical parameters were collected. Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Positive and Negative Syndrome Scale (PANSS) positive subscale were performed to detect the AS. Multiple linear regression analysis was used to analyze the correlation.</p></div><div><h3>Results</h3><p>The prevalence of AS in MDD patients with MetS was 85.96%, which was 1.79 times greater than that in patients with MDD alone (<em>P</em>&lt;0.05). MDD patients with MetS had a greater rate of attempted suicide, a higher HAMD total score, and a higher diastolic blood pressure than MDD patients without AS (<em>P</em>&lt;0.05). Their combination could distinguish AS in MDD patients. Moreover, HAMD score, thyroid-stimulating hormone (TSH) levels, PANSS positive score, and suicide attempts were related to HAMA scores in MDD patients with comorbid MetS (<em>P</em>&lt;0.05).</p></div><div><h3>Conclusion</h3><p>There is a significant frequency of AS in MDD patients with MetS. Multiple clinical indicators and metabolic markers are associated with AS in patients with MDD and MetS.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100217"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of oral blonanserin for schizophrenia in adolescents in China: Data from a 12-week post-marketing surveillance","authors":"Yun Yu ,&nbsp;Xijin Wang ,&nbsp;Ruiling Zhang ,&nbsp;Keqing Li ,&nbsp;Gang Wang ,&nbsp;Jindong Chen ,&nbsp;Meijuan Sun ,&nbsp;Zhiyuan Xun ,&nbsp;Xiaodong Yang ,&nbsp;Guijun Zhao ,&nbsp;Haiyun Li ,&nbsp;Xuejun Liu","doi":"10.1016/j.ejpsy.2023.07.005","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.005","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Blonanserin is a second-generation </span>antipsychotic<span> (SGA)for the treatment of schizophrenia and has been approved for use in Japan, South Korea and China. This analysis aimed to evaluate the effectiveness and safety of blonanserin in Chinese adolescent patients, using data from a post-marketing surveillance of blonanserin started in September 2018.</span></p></div><div><h3>Methods</h3><p>A 12-week, prospective, multi-center, open-label post-marketing surveillance was conducted. Patients in this analysis were stratified by age.</p></div><div><h3>Results</h3><p>78 patients with schizophrenia aged &lt; 18 years were included. The incidence of adverse drug reactions<span> in adolescent patients was 33.3% significantly higher than patients over 40 years old. After 12-week treatment, 8.1% of adolescent patients had a weight gain ≥ 7%, and it was not significantly different from other age groups. Mean Brief Psychiatric Rating Scale (BPRS) total score was significantly reduced at week 12, and the decline of anergia score and thought disturbance score of adolescent patients was significantly greater than in adults.</span></p></div><div><h3>Conclusions</h3><p>Blonanserin was well tolerated and effective in the treatment of schizophrenia in Chinese adolescent patients in real-world clinical practice. Blonanserin might be a reasonable choice for the treatment of schizophrenia in adolescent patients.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100222"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based umbrella review of non-invasive brain stimulation in anxiety disorders","authors":"Katia Nunes Sá ,&nbsp;Rachel Fontes Baptista ,&nbsp;Livia Shirahige ,&nbsp;Laís B. Razza ,&nbsp;Mateus Nogueira ,&nbsp;Maria Helena Faria Coura ,&nbsp;Leonardo Afonso-Santos ,&nbsp;Clarice Tanaka ,&nbsp;Abrahão Fontes Baptista ,&nbsp;Katia Monte-Silva ,&nbsp;André R. Brunoni","doi":"10.1016/j.ejpsy.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.01.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Although several meta-analyses have suggested the efficacy of non-invasive brain stimulation (NIBS) mainly in prefrontal brain areas to treat </span>mental disorders<span>, no synthetic approach has been performed for other psychiatric disorders rather than depression. The objective is to assess the available evidence of NIBS in the treatment of anxiety disorders.</span></p></div><div><h3>Methods</h3><p>An umbrella review (CRD42021239577) was performed only looking for reviews with meta-analyses of randomized clinical trials using a source strategy MeSH keywords in MEDLINE through Pubmed by two independent researchers. The effects of different methods of NIBS in anxiety disorders were assessed using the PICO strategy. The methodological quality was evaluated using AMSTAR-2 and certainty of evidence using the GRADE-pro framework.</p></div><div><h3>Results</h3><p><span><span>From 136 screening meta-analyses, 16 from 14 studies were included in the final analysis. Generalized Anxiety Disorder (GAD) and </span>Obsessive Compulsive Disorder<span> (OCD) respond best to low frequency repetitive transcranial magnetic stimulation (rTMS), while </span></span>Posttraumatic Stress Disorder (PTSD) has the largest effect size at high frequency rTMS. Panic Disorder (PD) has no evidence for clinical use of NIBS. There were not identified meta-analyses about other anxiety disorders. In general, the included studies had good methodological quality, but low to moderate evidence for clinical recommendation.</p></div><div><h3>Conclusion</h3><p>Available evidence reveals NIBS as an effective and safe approach to treat GAD, PTSD and OCD with low recommendation level to clinical application. A great heterogeneity of studies indicates the necessity to develop new randomized clinical trials applying NIBS to treat those and other mental disorders.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 167-181"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis in adults with autism spectrum disorder and attention deficit hyperactivity disorder at acute psychiatric wards","authors":"Hiromitsu Uno ,&nbsp;Wakaho Hayashi ,&nbsp;Akari Nakagawa ,&nbsp;Takeshi Otowa ,&nbsp;Hiroki Yamada ,&nbsp;Akira Iwanami","doi":"10.1016/j.ejpsy.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.12.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Psychotic symptoms, such as delusions and hallucinations, in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) have been increasingly reported in recent literature. In the present study, the prevalence and duration of psychotic symptoms, comorbid psychotic disorders, and clinical characteristics of adults with ASD and ADHD were retrospectively examined via a chart review.</p></div><div><h3>Methods</h3><p>The participants were 98 adults (mean age, 28.5 years; 72 men) who were admitted to the psychiatric emergency wards of Showa University Karasuyama Hospital, and who were diagnosed with ASD and/or ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria.</p></div><div><h3>Results</h3><p>Among 69 individuals with ASD, 21 (30.4%) experienced psychotic symptoms, and among 29 individuals with ADHD, 5 (17.2%) exhibited psychosis. While all psychotic symptoms were classified as transient and none had comorbidity with schizophrenia and other psychotic disorders in adults with ADHD, 38.1% of psychosis was classified as prolonged and 10.3% had comorbidity with schizophrenia and other psychotic disorders in adults with ASD.</p></div><div><h3>Conclusion</h3><p>The results showed that a significant proportion of adults with ASD and ADHD experience psychosis during their course of illness, and provide evidence for the existence of a shared etiology between neurodevelopmental and psychotic disorders.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 182-189"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished prefrontal hemodynamic response in adult attention deficit hyperactivity disorder: a multi-channel functional near-infrared spectroscopy study","authors":"Y. Zhang,&nbsp;M. Ran,&nbsp;X. Zhang,&nbsp;M. Wang,&nbsp;M. Wang,&nbsp;G. Jiang","doi":"10.1016/j.ejpsy.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.02.001","url":null,"abstract":"<div><h3>Background and aims</h3><p>Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Adult ADHD is currently diagnosed based only on subjective clinical and scoring measures, which inevitably lead to a low correct diagnosis rate. Hence, an effective auxiliary examination with higher sensitivity is needed.</p></div><div><h3>Method</h3><p>Twenty healthy controls (HC) subjects and 20 adults with ADHD were included in this study. The functional near-infrared spectroscopy (fNIRS) under verbal fluency test (VFT) was performed to detect cerebral cortex hemodynamics. Correlation and Receiver operating characteristic (ROC) curve analysis were employed to reveal the relationship between differences in hemodynamic response and clinical characteristics.</p></div><div><h3>Results</h3><p>The HbO response of adult ADHD in the prefrontal cortex (PFC) was significantly smaller than that of HC. HbO concentration changes in the corresponding channels were negatively correlated with the ASRS-inattention score. HbO concentration changes of channels 16 and 26 corresponding to the medial PFC might be helpful for the diagnosis of adult ADHD.</p></div><div><h3>Conclusion</h3><p>Adult ADHD patients have low activation of the PFC, changes of whose corresponding channels were significantly associated with attention deficit, indicating that fNIRS under VFT may be an effective auxiliary examination for adult ADHD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 160-166"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High molar ratios of tumor necrosis factor α (TNF α) soluble receptors I and II to the TNF ligand in human plasma from male veterans with comorbid posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI)","authors":"T.I. Morales ,&nbsp;C.E. Stamper ,&nbsp;L.A. Brenner","doi":"10.1016/j.ejpsy.2023.03.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.03.003","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with chronic inflammation, as inferred from increased, but variable, peripheral levels of cytokines. We sought proof of concept for the notion that peripheral cytokine binding proteins and/or soluble receptors can confound measures of cytokines in those with a history of physical and psychological traumatic exposures. Efforts were focused on one of the major cytokines involved in inflammation, tumor necrosis factor-α (TNF- α).</p></div><div><h3>Methods</h3><p>We examined blood plasma concentrations of TNF-α, its soluble receptors (TNF-soluble receptors (sR) I and TNFsRII), and C-reactive protein (CRP-1) in a cohort of US Veterans. In a previous study, CRP-1 was shown to be reduced by probiotic anti-inflammatory treatment in this patient cohort. All participants (<em>n</em> = 22) were diagnosed with PTSD and had a history of mild TBI with persistent post-concussive symptoms. Exclusion criteria included medications directly targeting inflammation.</p></div><div><h3>Results</h3><p>Molar concentrations of soluble TNFsRI and II exceeded concentrations of the TNF-α ligand. TNFsRI, but not TNFsRII, was significantly associated with CRP-1 (Spearman Rho correlations = 0.518; <em>p</em>=.016 and 0.365; <em>p</em> = .104, respectively).</p></div><div><h3>Conclusions</h3><p>TNF soluble receptors may bind to and sequester free TNF-α, suggesting that only measuring ligand concentrations may not provide a fully comprehensive view of inflammation, and potentially lead to inaccurate conclusions. TNFsRI concentration may provide a better estimate of inflammation than TNF-α for those with PTSD and post-acute mTBI with post-concussive symptoms, a hypothesis that invites further testing in larger studies.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 141-148"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We need to talk science","authors":"Daniel Guinart MD, PhD ,&nbsp;Victor Perez-Solà MD, PhD","doi":"10.1016/j.ejpsy.2023.07.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.003","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 139-140"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}