European Journal of Psychiatry最新文献

{"title":"Trauma and personality disorders in Danish treatment-seeking veterans","authors":"Ask Elklit ,&nbsp;Signe Fauerholdt Sørensen","doi":"10.1016/j.ejpsy.2025.100327","DOIUrl":"10.1016/j.ejpsy.2025.100327","url":null,"abstract":"<div><h3>Background &amp; objectives</h3><div>50.000 Danish soldiers have been deployed abroad during the last three decades. A recent study reported that 24 % were registered with either a psychiatric diagnosis or receiving psychotropic medication. We want 1) to explore the relationship between ICD-11 PTSD and complex PTSD (CPTSD), and severe personality pathology as well as clinical syndromes, and 2) to assess the mediating impact of social support, secondary trauma symptoms, and aggression for the two trauma diagnoses.</div></div><div><h3>Method</h3><div>142 male war veterans were assessed at intake to the outpatient services of a specialized trauma treatment facility. The participants completed an assessment battery. In addition to descriptive statistics, two multiple regression analyses were performed: one for PTSD and one for CPTSD.</div></div><div><h3>Results</h3><div>While less than half of the personality disorders and the clinical syndromes were associated with PTSD, almost all personality disorders and all the clinical syndromes were associated with CPTSD and to a much higher degree. 52 % of the variation of PTSD could be explained in the regression analysis with three significant factors in the final model: Anxiety, schizotypal personality disorder, and dissociation. In the similar analysis for CPTSD, 61 % of the variation was explained in the final model with Avoidant personality disorder and Negative Affectivity as significant factors. Social support and aggression were not significant predictors in either analysis.</div></div><div><h3>Conclusion</h3><div>The study supports the more severe sequelae associated with CPTSD compared to PTSD. The relationships between trauma disorders and personality pathology deserve more attention to inform the treatment of veterans.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100327"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-reported and performance-based emotional intelligence and its associations with psychopathological dimensions and insight dimensions in psychosis","authors":"Esther Rosado ,&nbsp;Amalia Zarzuela ,&nbsp;Gustavo J. Gil-Berrozpe ,&nbsp;Xabier Ansorena ,&nbsp;Julen Chato ,&nbsp;Victor Peralta ,&nbsp;Manuel J. Cuesta ,&nbsp;Ana M. Sánchez-Torres","doi":"10.1016/j.ejpsy.2025.100328","DOIUrl":"10.1016/j.ejpsy.2025.100328","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Individuals with psychotic disorders may display over the illness course a wide range of core deficits in clinical and cognitive domains, including social cognition (SC). One of the main domains of SC is emotional processing, a key component of emotional intelligence (EI). However, the extent to which EI, as self-perceived or performance-based, is related to psychopathological domains has been scarcely studied. This study aimed to examine the relationships between self-reported EI and performance-based EI with psychopathological and insight dimensions as well as to explore the correspondence between both types of EI assessments.</div></div><div><h3>Methods</h3><div>Seventy patients with psychotic disorders who were consecutively admitted to a psychiatric hospitalization unit were included. Psychotic, affective, and insight dimensions, as well as EI, were evaluated once psychopathological stability had been achieved.</div></div><div><h3>Results</h3><div>Manic symptoms were associated with greater emotional clarity (<em>r</em> = 0.25, <em>p</em> &lt; 0.05) and regulation (<em>r</em> = 0.30, <em>p</em> &lt; 0.05), whereas depressive symptoms were associated with lower emotional regulation (<em>r</em>=-0.25, <em>p</em> &lt; 0.05). No significant relationships were found between the EI measures and psychotic dimensions. Lack of feeling sick and lack of insight were related to worse performance-based EI (emotional management, <em>r</em>=-0.29 and <em>r</em>=-0.25, <em>p</em> &lt; 0.05) and self-reported EI (emotional attention, <em>r</em>=-0.24, <em>p</em> &lt; 0.05 and <em>r</em>=-0.31, <em>p</em> &lt; 0.01), and the former was also related to better emotional regulation (<em>r</em> = 0.26, <em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The discrepancy between self-reported and performance-based EI regarding their associations with psychopathological domains might be due to the different sources of assessment but may also add evidence to the need to integrate patient-reported outcome measures in the assessment of social cognition.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100328"},"PeriodicalIF":1.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation of the self-administered French version of the Functioning Assessment Short Test (FAST): Factor structure, reliability, validity, and sociodemographic predictors","authors":"Audrey Uyttersprot ,&nbsp;Nellia Bellaert ,&nbsp;Eduard Vieta ,&nbsp;Sandra Invernizzi ,&nbsp;Laurence Ris ,&nbsp;Laurent Lefebvre","doi":"10.1016/j.ejpsy.2025.100325","DOIUrl":"10.1016/j.ejpsy.2025.100325","url":null,"abstract":"<div><h3>Background and objectives</h3><div>The <em>Functioning Assessment Short Test</em> (FAST) is widely used to assess psychosocial functioning across psychiatric conditions. Despite extensive international validation, a validated French version of the self-administered FAST is currently lacking. This study aimed to evaluate the psychometric properties of the self-administered French FAST in a general adult population.</div></div><div><h3>Methods</h3><div>A total of 508 French-speaking adults aged 18–65 completed the FAST alongside standardized measures of depression and anxiety. Exploratory and confirmatory factor analyses and bifactor modeling evaluated the original six-factor structure. Reliability was assessed using Cronbach’s alpha and McDonald’s omega. Convergent validity was evaluated through multitrait-multimethod (MTMM) analysis and correlations with depression and anxiety. Generalized additive models (GAMs) examined non-linear associations between symptom severity and FAST scores, controlling for demographic covariates.</div></div><div><h3>Results</h3><div>The original six-factor structure was confirmed, and the bifactor model further supported interpretation of both total and subscale scores. Reliability was strong for the total FAST score (<em>α</em> = .86; <em>ω</em> = .90), whereas subscale reliability (<em>α</em> = .58–.80), with lower values for autonomy, cognitive, and leisure. MTMM analysis demonstrated moderate-to-high monotrait correlations (.51–.84), and moderate correlations with depressive (<em>r</em> = .46) and anxiety (<em>r</em> = .35) symptoms, supporting convergent validity. GAM analyses revealed a non-linear relationship between depressive symptoms and psychosocial impairment (<em>edf</em> = 2.91, <em>F</em> = 19.87, <em>p</em> &lt; .001), alongside significant effects of anxiety (<em>p</em> = .024) and employment status (<em>p</em> = .003).</div></div><div><h3>Conclusions</h3><div>The French self-administered FAST demonstrates robust psychometric properties and appears suitable for assessing psychosocial functioning in general adult populations, though caution is advised when interpreting autonomy, cognitive, and leisure subscales in non-clinical samples until further clinical validation is available.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100325"},"PeriodicalIF":1.5,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spanish validation of “The Awareness of Social Inference Test” (TASIT)","authors":"Lorena García-Fernández ,&nbsp;Nuria Cabot Iborra ,&nbsp;Verónica Romero-Ferreiro ,&nbsp;Miguel A. Álvarez-Mon ,&nbsp;Estela Jiménez López ,&nbsp;Guillermo Lahera ,&nbsp;Skye McDonald ,&nbsp;Roberto Rodriguez-Jimenez","doi":"10.1016/j.ejpsy.2025.100324","DOIUrl":"10.1016/j.ejpsy.2025.100324","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Social cognition (SC) plays a fundamental role in interpersonal functioning and is often impaired in severe mental disorders like schizophrenia. The Awareness of Social Inference Test (TASIT) is a reliable tool for assessing SC through audiovisual vignettes, but a validated Spanish version was lacking. This study aimed to translate, adapt, and validate TASIT for Spanish-speaking populations.</div></div><div><h3>Method</h3><div>A cross-sectional study was conducted with 659 participants, including healthy individuals and people with schizophrenia. The TASIT was translated and adapted following a rigorous procedure with the participation and guidance of the original author. Reliability, convergent, and discriminant validity were assessed using established psychometric tools.</div></div><div><h3>Results</h3><div>The Spanish version of TASIT demonstrated strong internal consistency across all sections, with McDonald’s omega coefficients ranging from ω = 0.71 to 0.89. Test-retest reliability was excellent, with correlation coefficients ranging from <em>r</em> = 0.81 to 0.87 (all <em>p</em> &lt; .001). Convergent validity was supported by significant correlations with established social cognition measures (<em>p</em> &lt; .05), and discriminant validity was confirmed by significant performance differences between healthy participants and those with schizophrenia (<em>p</em> &lt; .05).</div></div><div><h3>Conclusions</h3><div>The Spanish TASIT is a valid and reliable tool for assessing SC, with strong psychometric properties. It is suitable for both clinical and research settings.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100324"},"PeriodicalIF":1.5,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth group parent training for children with autism spectrum disorder and behavioral difficulties: feasibility, acceptability and preliminary efficacy","authors":"Imanol Setien-Ramos ,&nbsp;Teresa Alonzo-Castillo ,&nbsp;Aina García-Martínez ,&nbsp;Jorge Lugo-Marín ,&nbsp;María Martínez-Ramírez ,&nbsp;Josep Antoni Ramos-Quiroga ,&nbsp;Laura Gisbert-Gustemps","doi":"10.1016/j.ejpsy.2025.100319","DOIUrl":"10.1016/j.ejpsy.2025.100319","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Children with Autism Spectrum Disorder (ASD) frequently experience significant behavioral challenges that hinder adaptive functioning and increase caregiver stress. This study assesses the feasibility, acceptability, and preliminary efficacy of a telehealth-delivered group parent training program designed to address behavioral difficulties in children with ASD.</div></div><div><h3>Method</h3><div>An open-label, single-arm trial was conducted with children aged 3–12 years diagnosed with ASD and behavioral difficulties, recruited from a tertiary hospital’s autism care program. Program effectiveness was evaluated using parent-reported measures on their children and on themselves assessing behavior problems, parental stress, and quality of life. Data analysis included pre-post comparisons and follow-up assessments at 3 and 6 months.</div></div><div><h3>Results</h3><div>Twenty dyads parent-children were analyzed. Satisfaction with the program was moderate, with especially favorable feedback on the \"planned ignoring\" unit. Preferences for delivery mode and format varied, with suggestions to reduce the number of tasks and tailor content to individual needs. Significant reductions in irritability, lethargy, hyperactivity were observed immediately after treatment, with improvements in irritability and hyperactivity sustained at the 3- and 6-month follow-ups. Parental stress decreased significantly post-treatment but did not persist over time. Quality of life improved significantly compared to baseline, both immediately post-treatment and during follow-up evaluations.</div></div><div><h3>Conclusions</h3><div>The telehealth-delivered group parent training program demonstrated feasibility and moderate acceptability, with significant improvements in child behavior and caregiver quality of life. However, the reduction in parental stress was not sustained over time. These findings underscore the potential of telehealth-delivered group interventions for managing ASD-related behavioral issues and indicate areas for program refinement to enhance adherence and long-term effectiveness.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100319"},"PeriodicalIF":1.5,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of α-klotho/fibroblast growth factor 23 with cognitive features in euthymic older age patients with bipolar disorder","authors":"Wen-Yin Chen ,&nbsp;Chih Chiang Chiu ,&nbsp;Po-Hsiu Kuo ,&nbsp;Cho-Yin Huang ,&nbsp;Shang-Ying Tsia ,&nbsp;Chian-Jue Kuo ,&nbsp;Ying-Chih Cheng ,&nbsp;Po-Yu Chen ,&nbsp;Ming-Chyi Huang","doi":"10.1016/j.ejpsy.2025.100320","DOIUrl":"10.1016/j.ejpsy.2025.100320","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Cognitive aging is common among bipolar disorder (BD). The α-klotho/fibroblast growth factor 23 (FGF23) system has been associated with neuropsychiatric disorders and age-related diseases. This study aimed to investigate α-klotho and FGF23 levels in older-age bipolar disorder (OABD) and examine their associations with aging-related characteristics and cognitive function.</div></div><div><h3>Methods</h3><div>This study included 87 euthymic OABD, 83 younger-age bipolar disorder (YABD), and 20 healthy controls, to assess α-klotho and FGF23 levels. In OABD group, cognitive function was evaluated using the Brief Assessment of Cognition in Affective Disorders. Aging-related features were assessed, including daily physical activity, grip strength, and the Framingham Risk Score. We examined the correlations between α-klotho/FGF23 levels and aging-related features and explored their associations with cognitive domains in OABD.</div></div><div><h3>Results</h3><div>The FGF23 levels in OABD were lower compared to those in YABD. The α-klotho levels were not significantly different between three groups. A negative association was observed between FGF23 and global cognitive composite scores (<em>B</em> = -0.006, <em>p</em> = 0.005), particularly in motor speed (<em>B</em> = -0.006, <em>p</em> = 0.001), working memory (<em>B</em> = -0.007, <em>p</em> = 0.006), and verbal fluency (<em>B</em> = -0.002, <em>p</em> = 0.049). Additionally, α-klotho levels were positively associated with working memory (<em>B</em> = 0.735, <em>p</em> = 0.039).</div></div><div><h3>Conclusions</h3><div>FGF23 had a negative impact on cognitive domains, while α-klotho was positively associated with working memory in OABD. Future research should investigate the dysfunction of the α-klotho/FGF23 axis and incorporate additional validated aging markers in longitudinal studies to confirm the proposed biomarker relationships.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100320"},"PeriodicalIF":1.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional brain imaging of negative symptoms in schizophrenia: further evidence of prefrontal dysfunction","authors":"Paola Fuentes-Claramonte ,&nbsp;Ana Aquino-Servín ,&nbsp;María Ángeles Garcia-León ,&nbsp;Jordi Ortiz-Gil ,&nbsp;Pilar Salgado-Pineda ,&nbsp;Amalia Guerrero-Pedraza ,&nbsp;Salvador Sarró ,&nbsp;Emilio J. Inarejos-Clemente ,&nbsp;Raymond Salvador ,&nbsp;Peter J. McKenna ,&nbsp;Edith Pomarol-Clotet","doi":"10.1016/j.ejpsy.2025.100322","DOIUrl":"10.1016/j.ejpsy.2025.100322","url":null,"abstract":"<div><h3>Background and objectives</h3><div>An influential theory of negative symptoms in schizophrenia is that they are due to frontal lobe dysfunction, although this has not been consistently supported by functional imaging studies to date. Recently, our group found evidence of an association between negative symptoms and prefrontal hypoactivation during a novel executive task sensitive to goal neglect. The present study sought to extend this finding using a different functional imaging paradigm, the n-back working memory task.</div></div><div><h3>Methods</h3><div>Ninety-six medicated patients with schizophrenia were divided according to the Positive and Negative Symptoms Scale (PANSS) scores into groups with high negative symptom scores (HNS, N=70, negative symptom score range 15-34), and with low negative symptom scores (LNS, N=26, negative symptom score range 6-14). Along with 50 matched healthy controls, they underwent fMRI while performing the 2-back and 1-back versions of the n-back task.</div></div><div><h3>Results</h3><div>In the 2-back vs 1-back comparison, working memory-related activation was observed in lateral prefrontal and inferior parietal areas in all groups. The HNS patients, but not the LNS patients showed reduced activation in these task-related regions compared to the healthy controls. The HNS patients also showed hypoactivation in the right dorsolateral prefrontal cortex relative to the LNS patients, although this finding was no longer statistically significant when disorganization scores were added as a covariate.</div></div><div><h3>Conclusion</h3><div>Our results provide further evidence supporting the prefrontal hypothesis of negative symptoms, but also highlight the potential role of disorganization in modulating prefrontal activity.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100322"},"PeriodicalIF":1.5,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-efficacy for coping with cancer among cancer survivors with preexisting mental health conditions versus a control group","authors":"Miri Cohen ,&nbsp;Marc Gelkopf","doi":"10.1016/j.ejpsy.2025.100318","DOIUrl":"10.1016/j.ejpsy.2025.100318","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Self-efficacy for coping with cancer is a significant factor for cancer survivors’ quality of life, but it has not been examined among individuals with preexisting severe mental health conditions (SMHC). This study compared perceptions of self-efficacy for coping with cancer among cancer survivors with and without precancer SMHC; quality of communication with the oncology team and depressive symptoms as antecedents of self-efficacy; and the mediating role of self-regulation (cognitive reappraisal and expressive suppression) between antecedents and perceived self-efficacy for coping with cancer.</div></div><div><h3>Methods</h3><div>Participants were 170 adult cancer survivors with preexisting SMHC and 80 with no SMHC, aged 20–71, and 1–5 years since diagnosis. They filled out questionnaires in a face-to-face meeting. Multigroup path analysis was conducted using structural equation modeling.</div></div><div><h3>Results</h3><div>Individuals with SMHC reported lower self-efficacy for coping with cancer and higher levels of depressive symptoms. In the SMHC group, cognitive reappraisal mediated the association between perceived communication quality and self-efficacy, and expressive suppression mediated the relationship between depressive symptoms and self-efficacy.</div></div><div><h3>Conclusions</h3><div>The results highlight the deficiency in self-efficacy for coping with cancer in individuals with SMHC, a prominent factor for treatment adherence and quality of life among cancer survivors. Findings suggest self-efficacy may be strengthened via more emphatic and attentive communication with the oncology team and fostering effective emotion regulation strategies.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100318"},"PeriodicalIF":2.5,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current state and future directions of biomarkers for bipolar disorder: A systematic review of studies from 2013 to 2025","authors":"Guocan Ma ,&nbsp;Fengyi Hao ,&nbsp;Soon-Kiat Chiang ,&nbsp;Dewen Zhou ,&nbsp;Roger C. Ho ,&nbsp;Roger S. McIntyre","doi":"10.1016/j.ejpsy.2025.100317","DOIUrl":"10.1016/j.ejpsy.2025.100317","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Bipolar disorder (BD) is a severe mental disorder whose diagnosis heavily relies on subjective symptomatic assessments, thus a need for an objective tool to assist in the timely identification and treatment of BD.</div></div><div><h3>Methods</h3><div>We systematically reviewed the performance of objective diagnostic biomarkers for classification of BD that presented sensitivity and specificity values. A search on Ovid MEDLINE® ALL, PubMed, as well as manual searching were performed for literature dating from December 2013 to February 2025.</div></div><div><h3>Results</h3><div>Sixty-one studies were included in the review. Twenty-four of them reported mainly molecular, fluid-based biomarkers, twenty-five reported neurophysiological examinations as biomarkers, and six reported other forms of biomarkers. The most accurate biomarkers included voice features, apoptosis-related long non-coding RNAs, PIK3R1 (Phosphoinositide-3-kinase regulatory subunit 1) and FYN mRNAs, electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS)<strong>,</strong> multimodal magnetic resonance imaging (MRI), and serum VGF protein, with area under the receiver operating characteristic curve (AUC) or accuracy values of greater than 0.93. The majority (thirty-six) of the studies utilized machine learning-based classification algorithms.</div></div><div><h3>Conclusions</h3><div>The results have been promising and replicated for some biomarkers, but these results still need to be validated in larger samples. Future studies should focus on constructing larger cohorts of specific clinical subtypes of BD, predictive utility studies for BD patients initially diagnosed as major depressive disorder (MDD), and utilization of multimodal assessment and machine learning techniques.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100317"},"PeriodicalIF":2.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of suicide and COVID-19 in different countries: Epidemiological data for 2020","authors":"Jimena María Merayo-Cano ,&nbsp;Alejandro Porras-Segovia ,&nbsp;Luis Gutiérrez-Rojas ,&nbsp;Enrique Baca-García","doi":"10.1016/j.ejpsy.2025.100316","DOIUrl":"10.1016/j.ejpsy.2025.100316","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Suicide is a major public health problem. The number of years of potential life lost (YPLL) provides a complementary perspective for mortality assessment and health policy development. Previous studies have compared YPLL due to suicide with YPLL due to COVID-19 in the United States and Spain. However, no previous studies have explored these data worldwide to establish an adequate comparison. We believe that suicide deaths do not receive adequate attention when compared, for example, to deaths attributable to COVID-19. 1 In this case we have performed a comparative analysis of the years of life lost due to suicide and the pandemic, based on data that have been published in recent years. This study aims to quantify the global impact of suicide versus COVID-19 in terms of YPLL.</div></div><div><h3>Methods</h3><div>Our source was the World Health Organization mortality database as of September 2023. We included countries that had data on all-cause mortality for ages 0-75, presented by age groups in 2020. For suicide and COVID-19, YPLL and the percentage of YPLL over total causes of death were analyzed.</div></div><div><h3>Results</h3><div>In 10 out of 22 countries (45 %), YPLL due to suicide exceeded those due to COVID-19.</div></div><div><h3>Conclusions</h3><div>The countries where the impact of suicide was greater than that produced by COVID-19 were Australia and Germany. Although all countries in the world for which data was available were analyzed, Europe was the region with the highest representation. In the case of Europe, the world region with the largest number of countries for which data are available, half of the countries analyzed have a higher number of years of potential life lost as a result of suicide than those lost due to COVID-19, the disease that became one of the leading causes of death in record time, with devastating socio-economic impact and damage. It is necessary to raise awareness about the impact of suicide. Suicide prevention requires a coordinated effort worldwide.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 4","pages":"Article 100316"},"PeriodicalIF":2.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}