European Journal of Psychiatry最新文献

{"title":"Worries concerning a scientific review article on the cognitive effects of cannabis in psychotic patients","authors":"Jørgen G. Bramness, Elena Prokofyeva, Jonna Levola, John Söderholm","doi":"10.1016/j.ejpsy.2026.100384","DOIUrl":"10.1016/j.ejpsy.2026.100384","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 4","pages":"Article 100384"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149211115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age modifies the association between sex and involuntary admission in psychotic disorders: a retrospective cross-sectional study","authors":"Marina Delgado-Marí,&nbsp;Alba Toll,&nbsp;Maria Giralt-López,&nbsp;Tatiana Bustos-Cardona,&nbsp;Ana Ibáñez-Caparrós,&nbsp;Aurea Fernández-Ribas","doi":"10.1016/j.ejpsy.2026.100376","DOIUrl":"10.1016/j.ejpsy.2026.100376","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Involuntary psychiatric admission is common among patients with psychotic disorders, but demographic factors associated with its use remain incompletely understood. Previous findings regarding sex have been inconsistent. We examined whether the association between sex and involuntary admission varies according to age.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cross-sectional study of 254 patients with psychotic disorders admitted to an acute psychiatric inpatient unit between February 2018 and May 2023. Multivariable logistic regression examined sex, age, and their interaction in relation to involuntary admission.</div></div><div><h3>Results</h3><div>Overall, 179 patients (70.5%) were admitted involuntarily. Men and women had similar crude rates of involuntary admission. Female sex (OR = 4.876; 95% CI: 1.147–20.722; p = 0.032) and the female sex-by-age interaction (OR = 0.969; 95% CI: 0.938–0.999; p = 0.046) were statistically significant in the model. Predicted probabilities remained relatively stable across age in men but declined with increasing age in women, with younger women showing the highest probability of involuntary admission.</div></div><div><h3>Conclusion</h3><div>Age modifies the association between sex and involuntary admission in psychotic disorders, with younger women showing the highest probability of involuntary admission. These findings highlight the importance of considering sex-by-age interactions and may inform more individualized clinical assessment and service planning.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 4","pages":"Article 100376"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a patient-reported experience scale for acute psychiatric inpatient units: The QEUH","authors":"Ariadna Galán,&nbsp;Aitana Magdalena,&nbsp;Anna Urbea,&nbsp;Lola Riesco,&nbsp;Judit M Fàbregas,&nbsp;Quintí Foguet,&nbsp;David Almenta,&nbsp;Emma Puigoriol,&nbsp;Meritxell Grau,&nbsp;Josep M. Haro,&nbsp;Juan C. Pascual,&nbsp;Iluminada Corripio","doi":"10.1016/j.ejpsy.2026.100380","DOIUrl":"10.1016/j.ejpsy.2026.100380","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Patient-reported experience measures (PREMs) have become increasingly important for evaluating the quality of psychiatric care and supporting person-centered services. However, few psychometrically validated instruments have been specifically developed to assess patient experience during acute psychiatric hospitalization. This study aimed to develop and validate the QEUH (“What Is Your Experience as a User of a Psychiatric Inpatient Unit?”), a PREM designed for acute psychiatric inpatient units.</div></div><div><h3>Methods</h3><div>QEUH was developed using a participatory mixed-methods approach combining qualitative data obtained from patients, relatives, and mental health professionals with quantitative psychometric analyses. The preliminary questionnaire was administered to 141 patients admitted to an acute psychiatric inpatient unit. Psychometric evaluation included exploratory and confirmatory factor analyses, internal consistency, test–retest reliability, convergent validity using the Rome Opinion Questionnaire for Psychiatric Services (RMD), and analyses of sociodemographic and clinical variables.</div></div><div><h3>Results</h3><div>Factor analyses supported a two-factor structure in the current sample reflecting “Experience of care received” and “Experience of participation during hospitalization”. The final 19-item self-reported questionnaire demonstrated high internal consistency (Cronbach's α = 0.89), excellent test–retest reliability (ICC = 0.96), and satisfactory convergent validity with the RMD (<em>r</em> = 0.72, <em>p</em> &lt; .001). QEUH scores were not significantly associated with age, sex, psychiatric diagnosis, or involuntary admission.</div></div><div><h3>Conclusions</h3><div>QEUH is a brief, feasible, and psychometrically robust PREM for assessing patient experience in acute psychiatric inpatient units. Its participatory development and strong psychometric properties support its potential use for routine service evaluation and quality improvement within contemporary person-centered psychiatric care.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 4","pages":"Article 100380"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149153757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Notice to “Cognitive reserve and brain plasticity in cannabis-using psychosis patients: A systematic review of neuroimaging and intervention studies” [The European Journal of Psychiatry, Volume 40, Issue 1, 100332]","authors":"Valerio Ricci,&nbsp;Giovanni Martinotti,&nbsp;Giuseppe Maina","doi":"10.1016/j.ejpsy.2026.100383","DOIUrl":"10.1016/j.ejpsy.2026.100383","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 4","pages":"Article 100383"},"PeriodicalIF":1.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149211114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propranolol treatment of traumatic memories in adults with post-traumatic symptoms: A randomized controlled trial in an outpatient setting","authors":"Mansfield Mela,&nbsp;Tamara Hinz,&nbsp;Curtis Chicoine,&nbsp;Alexandra M. Zidenberg,&nbsp;Hyun J. Lim,&nbsp;Claudia Madampage,&nbsp;Robin Menzies","doi":"10.1016/j.ejpsy.2026.100363","DOIUrl":"10.1016/j.ejpsy.2026.100363","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Re-experiencing traumatic events is common and often accompanied by emotional distress. While propranolol has been proposed as a treatment for traumatic memories based on reconsolidation theory, evidence remains mixed. This randomized controlled trial aimed to determine the effectiveness of brief propranolol treatment on participants with traumatic memories and associated symptoms (not necessarily meeting diagnostic criteria for PTSD).</div></div><div><h3>Methods</h3><div>A double-blind, placebo-controlled randomized trial was conducted in an outpatient setting in a Midwestern Canadian city. Seventy-five participants (propranolol: n=38; placebo: n=37) were assessed at baseline, 4 weeks, and 8 weeks post-intervention. Propranolol was administered following memory reactivation, in keeping with reconsolidation theory; the implications of this timing are discussed. Participants completed primary outcome measures including the Clinician-Administered PTSD Scale (CAPS), Impact of Event Scale-Revised (IES-R), and Traumatic Memory Description Measure (TMDM), alongside clinical interviews assessing anxiety, depression, and traumatic memory experiences.</div></div><div><h3>Results</h3><div>No significant differences emerged between groups on primary outcome measures assessing traumatic memories and their consequences. However, anxiety, distress, and trauma-related symptoms decreased two-fold over time across both groups. Clinician and self-ratings of improvement were statistically higher in the propranolol group compared to placebo. The treatment group demonstrated perfect adherence, which was representatively higher than the placebo group.</div></div><div><h3>Conclusion</h3><div>Propranolol did not differ significantly from placebo on primary outcome measures of traumatic memory and associated symptom severity. Both groups showed clinically meaningful within-group reductions over time. Subjective global improvement ratings were higher in the propranolol group, though these secondary findings should be interpreted cautiously. The results do not support propranolol as an efficacious treatment for traumatic memories but highlight the potential therapeutic value of memory reactivation procedures and warrant further controlled investigation. The timing of propranolol administration in relation to memory reactivation, specifically post-reactivation in the current protocol, may be a critical limiting factor.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 3","pages":"Article 100363"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep problems and psychological well-being in patients with depression: A cross-sectional study of 7,051 individuals","authors":"Frederikke Hørdam Gronemann,&nbsp;Ida Kim Wium-Andersen,&nbsp;Merete Osler,&nbsp;Marie Kim Wium-Andersen","doi":"10.1016/j.ejpsy.2026.100364","DOIUrl":"10.1016/j.ejpsy.2026.100364","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Psychological well-being is markedly reduced in patients with depression. This study examined the association between self-reported sleep problems and psychological well-being in a large cohort of patients with depression prior to treatment initiation.</div></div><div><h3>Methods</h3><div>We included 7051 adults with a primary diagnosis of depression or dysthymia (ICD-10 F32, F33, or F34.1) enrolled in a standardized depression treatment program in the Capital Region of Denmark between 2007 and 2022. Sleep problems were assessed using the sleep item from the Major Depression Inventory (MDI), and psychological well-being was measured by the 5-item World Health Organization Well-Being Index (WHO-5). Associations were estimated using multivariable linear regression with robust standard errors, adjusting for demographic and clinical variables including depression severity, anxiety, medication use, and somatic comorbidities.</div></div><div><h3>Results</h3><div>Sleep problems were highly prevalent, with only 5.5% of patients reporting no sleep problems. Complaints of too little sleep were more common than complaints of too much sleep. Self-reported sleep problems were associated with lower psychological well-being in a stepwise manner. Compared with patients without sleep problems, those reporting short sleep, long sleep or with both had lower well-being scores (β = -11.1, -9.8, and -12.5, respectively), and associations remained robust after multivariable adjustment. No interaction by sex was observed.</div></div><div><h3>Conclusion</h3><div>In this large clinical sample of patients with depression, self-reported sleep problems were highly prevalent and associated with graduated lower psychological well-being.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 3","pages":"Article 100364"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the suicidal history self-rating scale (SHSS) in young adults: A bifactor model approach to suicide risk assessment","authors":"Alberto Sanchez,&nbsp;Marco Innamorati,&nbsp;Nicole Bungaro,&nbsp;Simone Belli,&nbsp;Chiara Castelletti,&nbsp;Adriana García-Ramos,&nbsp;Wala Ayad Ahmed,&nbsp;Alejandro de la Torre-Luque","doi":"10.1016/j.ejpsy.2026.100366","DOIUrl":"10.1016/j.ejpsy.2026.100366","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Accurately assessing suicide risk requires tools that capture both its multidimensional nature and its temporal course. This study analyzes the psychometric properties of the Spanish version of the Suicidal History Self-Rating Scale (SHSS), a self-reported, multidimensional instrument designed to assess suicidal ideation and behavior across two time frames: the last 12 months and the lifetime before.</div></div><div><h3>Methods</h3><div>Confirmatory factor analysis (CFA) was performed to compare unidimensional, two-factor, and bifactor models. Reliability was assessed using Omega coefficients, and concurrent validity was evaluated through correlations with the Paykel scale. The study used a convenience sample of 817 Spanish young adults (18–35 years old).</div></div><div><h3>Results</h3><div>The bifactor models provided the best fit, identifying a prominent general suicide risk factor. Specific factors varied by period: suicidal ideation performed better in the 12-month frame, while suicidal behavior was more stable in the lifetime frame. The SHSS demonstrated excellent internal consistency (<span><math><mrow><msub><mi>ω</mi><mi>T</mi></msub><mo>=</mo><mn>0.96</mn><mo>−</mo><mn>0.97</mn></mrow></math></span>) and strong concurrent validity with the Paykel scale (<span><math><mrow><mi>ρ</mi><mo>=</mo><mn>0.645</mn><mo>−</mo><mn>0.695</mn></mrow></math></span>).</div></div><div><h3>Conclusions</h3><div>These findings support the SHSS as a reliable, valid, and efficient self-report tool for screening suicide risk in young adults. Its 12-month subscale might be valuable in emergency psychiatry for predicting imminent risk. Simultaneously, the lifetime assessment allows for the identification of historical “acquired capability” and long-term risk trajectories.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 3","pages":"Article 100366"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal biomarkers in schizophrenia spectrum disorder — structural, functional, and computational insights","authors":"Sara Fin,&nbsp;Alireza Moayedikia,&nbsp;Mojtaba Golzan","doi":"10.1016/j.ejpsy.2026.100369","DOIUrl":"10.1016/j.ejpsy.2026.100369","url":null,"abstract":"<div><div>Schizophrenia spectrum disorder (SSD) is a complex neurodevelopmental disorder characterised by hallucinations, social withdrawal, and deficits in working memory and decision-making. Its underlying causes are not yet fully understood, but mounting evidence suggests that genetic, immunological, and environmental influences during the neurodevelopmental period contribute to its pathogenesis. Identifying measurable biomarkers that reflect the disorder's clinical features and progression is crucial for understanding its etiopathogenesis. As part of the central nervous system, the retina may serve as an important structure for identifying such biomarkers, given the structural and functional abnormalities observed in individuals with SSD. The unique properties of the human eye—translucence and low myelin and glial cell content—allow non-invasive examination of central nervous system microstructure and function. Growing evidence highlights retinal abnormalities in SSD, reinforcing their potential as candidate biomarkers and providing insights into the disorder's neurodevelopmental and neurodegenerative biology. Recent advances in artificial intelligence and machine learning have demonstrated remarkable capabilities in detecting these retinal changes, with convolutional neural networks achieving up to 95% classification accuracy and AUC values of 0.98 in controlled research settings. In this review, we discuss the retinal pathology associated with SSD, explore how these findings could offer new perspectives for future research into the molecular pathology of the disorder, examine the role of artificial intelligence and machine learning in retinal biomarker analysis, and explain their potential implications as candidate diagnostic biomarkers warranting further validation.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 3","pages":"Article 100369"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spain’s responsiveness to population mental health needs: lessons from a critical comparison with other European countries","authors":"Javier-David Lopez-Morinigo,&nbsp;Mercedes Navío,&nbsp;Celso Arango","doi":"10.1016/j.ejpsy.2026.100365","DOIUrl":"10.1016/j.ejpsy.2026.100365","url":null,"abstract":"<div><div>This study compared Spain’s responsiveness in healthcare and the non-healthcare systems to population mental health (MH) needs with that of all other European Union (EU) countries and the United Kingdom (UK) using data from the 2023 Headway Initiative.</div><div>Regarding responsiveness in healthcare, Spain scored 3.4 (out of 10), ranking 17^th, whereas in the non-healthcare system Spain scored 4.5, ranking 25^th.</div><div>Spain’s responsiveness to population MH needs remains comparatively lower than that of most European countries. Improved governance and integration of services, digitalisation, research and prevention should guide future MH policies in Spain, for which increased MH expenditure will be required.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 3","pages":"Article 100365"},"PeriodicalIF":1.5,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148499531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and biochemical correlates of rapid cycling in bipolar disorder: A 20-year inpatient study","authors":"Anna Pan ,&nbsp;Enrico Capuzzi ,&nbsp;Francesca Legnani ,&nbsp;Luigi Piccirilli ,&nbsp;Martina Di Paolo ,&nbsp;Alessandro Ceresa ,&nbsp;Cecilia Maria Esposito ,&nbsp;Luisa Cirella ,&nbsp;Teresa Surace ,&nbsp;Ilaria Tagliabue ,&nbsp;Massimo Clerici ,&nbsp;Massimiliano Buoli","doi":"10.1016/j.ejpsy.2026.100355","DOIUrl":"10.1016/j.ejpsy.2026.100355","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Rapid cycling (RC) is a severe course specifier of bipolar disorder (BD), associated with worse clinical outcomes and increased treatment complexity. The objective of this study is to identify differences in clinical and biochemical parameters between bipolar patients with or without rapid cycling (RC).</div></div><div><h3>Methods</h3><div>A total of 468 inpatients were included in the present study. Demographic, clinical and biochemical data, related to the first day of hospitalization, were obtained through a screening of the clinical charts and intranet hospital applications. The two groups identified by the lifetime presence of RC were compared by t tests for continuous variables and χ² tests for qualitative ones; logistic regression models were subsequently performed.</div></div><div><h3>Results</h3><div>Logistic regressions showed that patients with versus without RC: were more frequently hospitalized for a depressive episode (p &lt; 0.01), had more previous psychiatric hospitalizations (p &lt; 0.01), presented more often multiple medical comorbidity (p = 0.05) and seasonality (p = 0.02) as well as lower Global Assessment of Functioning (GAF) scores at the time of hospitalization (p = 0.02).</div><div>RC patients also exhibited lower creatine phosphokinase (CPK) (p &lt; 0.01) and neutrophil levels (p &lt; 0.01).</div></div><div><h3>Conclusions</h3><div>The presence of RC is important in designing a personalized treatment of bipolar patients as it is associated with (1) clinical variables of greater severity, (2) the tendency to a depressive profile and (3) multiple medical comorbidities. Further multi-center studies are needed to confirm the results of the present study in a framework of precision psychiatry.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100355"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147797303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}