European Journal of Psychiatry最新文献

{"title":"Development of the Spanish version of the Parents' Self-Stigma Scale","authors":"Andreu Nolasco ,&nbsp;Giovanna Tassara ,&nbsp;Laura Borredà ,&nbsp;Manuel Giron ,&nbsp;Nayara Tamayo-Fonseca ,&nbsp;Joaquín Moncho ,&nbsp;Pamela Pereyra-Zamora ,&nbsp;Manuel Gómez-Beneyto","doi":"10.1016/j.ejpsy.2024.100275","DOIUrl":"10.1016/j.ejpsy.2024.100275","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>It is known that those who regularly interact with people with mental illness, such as family members, caregivers and mental health professionals, can be subjected to public stigmatization and that they may eventually develop self-stigmatization. Despite the relevance of parental self-stigma for the upbringing and treatment of children with psychiatric problems, only one instrument has been developed to identify it, the Parents' Self-Stigma Scale (PSSS). The lack of a similar instrument in Spanish motivated the present study, with the aim of developing a Spanish version of the PSSS.</div></div><div><h3>Methods</h3><div>After translating the PSSS, it was administered to two samples of parents of children who were treated consecutively in child-adolescent mental health centres in Reus and Valencia. The Reus sample was subjected to Exploratory Factor Analysis (EFA) and the Valencia sample to Confirmatory Factor Analysis (CFA), taking as reference the factor load matrix obtained in Reus. Temporal stability was estimated by calculating the ICC between the results obtained in two administrations of the questionnaire separated by four weeks. To estimate convergent validity, the correlation of the questionnaire score with the scores of the Rosenberg Self-Esteem Scale and the Schwarzer General Self-Efficacy Scale was calculated.</div></div><div><h3>Results</h3><div>The EFA showed the existence of three factors, “Bad Father”, “Self-blame” and “Self-shame”, which confirms the structural equivalence of the Spanish version and the original PSSS. Likewise, it was confirmed that the Spanish version is temporarily stable and valid.</div></div><div><h3>Conclusions</h3><div>The results obtained show that the Spanish version of the PSSS is semantically and psychometrically equivalent to the original PSSS, and that it has acceptable temporal stability and convergent validity.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100275"},"PeriodicalIF":2.5,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Screening time for delirium in dementia patients matters: Validation of the Spanish version of the RADAR","authors":"Esteban Sepúlveda ,&nbsp;Ester Bermúdez ,&nbsp;Lourdes Vallinoto ,&nbsp;Julia Sánchez ,&nbsp;Paola Saura ,&nbsp;Pau Piany ,&nbsp;Eva Viñuelas ,&nbsp;Marta Ciutat ,&nbsp;José Palma ,&nbsp;Imma Grau ,&nbsp;Elisabet Vilella ,&nbsp;Philippe Voyer ,&nbsp;José G. Franco","doi":"10.1016/j.ejpsy.2024.100272","DOIUrl":"10.1016/j.ejpsy.2024.100272","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Delirium is frequently underdiagnosed in patients with dementia. The <em>Repérage Actif du Delirium Adapté à la Routine</em> (RADAR) can be adapted to nursing routines for delirium screening. We validated the Spanish RADAR version and determined the best time of day for its administration.</div></div><div><h3>Methods</h3><div>All dementia patients admitted to a postacute care centre on one day were independently assessed by nurses using the RADAR at the morning and midday and by geriatricians with the Delirium Diagnostic Tool-Provisional (DDT-Pro) reference standard for delirium and subsyndromal delirium (SSD). We evaluated the test–retest temporal stability of the morning and midday RADAR assessments, the RADAR validity considering these two time points and then, the suitability of the DDT-Pro for diagnostic confirmation.</div></div><div><h3>Results</h3><div>Of 34 dementia patients included, 47.1 % had delirium, and 83.3 % had behavioural, mental or neurological disturbances that made diagnostic assessment difficult. The test–retest temporal stability of the RADAR was moderate, which is consistent with the fact that the diagnostic accuracy of the midday assessment for delirium (79.4 %) was better than that of the morning (73.5 %). The screening accuracy when also considering SSD, accounting for either assessment time, was 79.4 %. Several correspondence and correlation analyses support the use of DDT-Pro for confirmation and assessment of delirium severity after RADAR screening.</div></div><div><h3>Conclusion</h3><div>The RADAR is useful for the screening of delirium and SSD by nurses in dementia patients and midday assessments have greater diagnostic validity than morning assessments. Screened patients need subsequent diagnosis confirmation before starting therapeutic measures.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100272"},"PeriodicalIF":2.5,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burnout in mental health professionals and its relation with their attitudes towards mental illness","authors":"Francisco Del Olmo-Romero ,&nbsp;Carlos Rebolleda-Gil ,&nbsp;Pedro Varandas ,&nbsp;Manuel Martín-Carrasco ,&nbsp;María González-Blanco ,&nbsp;Giampaolo Perna ,&nbsp;Edith Pomarol-Clotet ,&nbsp;Ana C. Martinez-Cabezón ,&nbsp;Raúl Huerta-Ramírez ,&nbsp;Raymond Salvador ,&nbsp;The Inter NOS Working Group","doi":"10.1016/j.ejpsy.2024.100289","DOIUrl":"10.1016/j.ejpsy.2024.100289","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Staff burnout is a concern in the mental health field, in terms of its prevalence and its association with a range of undesirable outcomes. Recent research suggests there is a relationship between mental health professionals’ (MHPs) burnout and stigmatizing attitudes towards their patients, probably leading to deleterious effects on the quality of their care. We measured burnout in a sample of professionals working in a wide range of mental health facilities in Spain, Portugal and Italy, and analyzed (1) its relationship with a set of relevant sociodemographic variables and (2) its influence on their stigmatizing attitudes.</div></div><div><h3>Methods</h3><div>We administered a survey including the Maslach Burnout Inventory (MBI) and two questionnaires related to stigmatizing attitudes: The Community Attitudes towards the Mentally Ill (CAMI) and the Attribution Questionnaire (AQ-27). Sociodemographics including information on profession, work setting and country were also registered.</div></div><div><h3>Results</h3><div>1525 professionals of the surveyed population (34.06 %) completed the survey. Burnout scores were significantly related to many of the sociodemographic variables. Profession and country were the strongest and most consistently associated to the three dimensions of burnout (i.e., Emotional Exhaustion (EE), Depersonalization (Dp) and Personal Achievement (PA)) always with a <em>p</em> &lt; 0.001. Fittings of linear models predicting stigmatizing attitudes from burnout pointed to PA as the most influential variable, being statistically significant for 11 of the 13 stigma variables, followed by both EE and Dp which were significant for 6 of the variables. Finally, higher adjusted R2 from the fitted models showed that burnout was more influential than profession, work setting or country in many of the stigma variables including Anger, Dangerousness, Fear, Help, Restrictiveness and Ideology.</div></div><div><h3>Conclusion</h3><div>Results from this study indicate that burnout of MHPs is related to a wide range of sociodemographic factors, with profession and country being remarkably significant. MHPs reporting higher burnout (especially lower personal achievement at work) have more negative attitudes towards their patients and support more coercive and restrictive approaches in their care. Staff burnout seems to explain most of their stigmatizing attitudes more than personal and professional variables. Thus, interventions to diminish burnout might have a positive influence on mental health care. Future studies should include organizational variables, more specific scales for stigma in MHPs, and have a follow-up design.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100289"},"PeriodicalIF":2.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of the TaySH (Transitional Age Youth Self-Harm) Program in the management of Non-Suicidal Self-Harm (NSSI) in outpatient adolescents and young adults: A non-randomized controlled pilot study","authors":"Natalia Calvo ,&nbsp;Silvia Amoretti ,&nbsp;Jorge Lugo-Marín ,&nbsp;Montserrat Oriol ,&nbsp;Citlallí Perez ,&nbsp;Josep Antoni Ramos-Quiroga ,&nbsp;Marc Ferrer","doi":"10.1016/j.ejpsy.2024.100288","DOIUrl":"10.1016/j.ejpsy.2024.100288","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Non-suicidal self-injury (NSSI) has become one of the most severe mental health problems among adolescents and young adults worldwide, especially in clinical populations. The main objective of this non-randomized pilot study is to demonstrate the effectiveness of the TaySH Program in a clinical sample of 37 outpatients aged 14 to 25 years (<em>M</em> = 16.70, SD= 1.51), TAY (Transitional age youth) developmental stage.</div></div><div><h3>Methods</h3><div>All participants underwent the baseline or pre-treatment assessment and 28 patients completed the 12-week intervention treatment and underwent post-treatment evaluation through different interviews and self-reports. The primary outcome was the reduction of NSSI, and the secondary outcomes were suicide risk, emotional dysregulation, the psychopathological clinical manifestations of impulsivity, depressive symptoms and anxiety, and psychosocial functioning.</div></div><div><h3>Results</h3><div>The frequency of NSSI behaviors decreased significantly from a mean of 3.32 (SD=4.07) episodes per week at baseline to 0.29 (SD=0.98) episodes per week post-treatment (<em>p</em> &lt; 0.001, Cohen's <em>d</em> = 0.458). This reduction was accompanied by an improvement in associated psychopathological symptoms, leading to better psychosocial functioning among program participants.</div></div><div><h3>Conclusions</h3><div>The results suggest that the TaySH Program is a promising early intervention for managing NSSI in this population. Future studies should examine the maintenance of the changes achieved, especially concerning the reduction of the psychopathology's tendency toward chronicity.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100288"},"PeriodicalIF":2.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social support and emotion dysregulation: A serial pathway from child maltreatment to depressive symptoms in adults with affective disorders","authors":"Rachel Hsiao Shen Tan ,&nbsp;Sherilyn Shi Hui Chang ,&nbsp;Wen Lin Teh ,&nbsp;Nisha Chandwani ,&nbsp;Mythily Subramaniam ,&nbsp;Jianlin Liu","doi":"10.1016/j.ejpsy.2024.100286","DOIUrl":"10.1016/j.ejpsy.2024.100286","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Child maltreatment is a risk factor for psychopathology in adulthood, and it is important to elucidate avenues for intervention. Social support and emotion dysregulation are two psychosocial factors which mediate the relationship between child maltreatment and psychopathology; however, few studies have examined both simultaneously in an Asian clinical context. This study aimed to investigate the dual roles of social support and emotion dysregulation in the pathway from child maltreatment to depressive symptoms in adulthood by testing three competing pathway models.</div></div><div><h3>Methods</h3><div>A total of 200 participants (Mean age = 36.53; 78 % Chinese ethnicity) with a primary diagnosis of affective disorder were recruited from a tertiary psychiatric hospital in Singapore. Respondents completed self-report measures of child maltreatment exposure, depressive symptoms, perceived social support, and emotion dysregulation. Pathway analyses based on ordinary least squares regressions were conducted using the PROCESS 4.1 tool.</div></div><div><h3>Results and conclusions</h3><div>Higher exposure to child maltreatment was associated with lower perceived social support, greater emotion dysregulation, and more depressive symptoms. Pathway analyses revealed a significant indirect effect of child maltreatment on depressive symptoms via perceived social support and emotion dysregulation (<em>b</em> = 0.0172). This indirect effect was significant for emotional neglect while controlling for other forms of maltreatment (<em>b</em> = 0.0914). Findings provide conceptual support for the serial pathway involving social support and emotion dysregulation in the relationship between child maltreatment and depressive symptoms, highlighting the need to target both interpersonal and intrapersonal factors in treating clinical populations with child maltreatment exposure.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100286"},"PeriodicalIF":2.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness as a risk factor for dementia and its mediators: A longitudinal cohort analysis of UK Biobank data","authors":"Marine Echegut ,&nbsp;Natalie Shoham ,&nbsp;Naaheed Mukadam","doi":"10.1016/j.ejpsy.2024.100284","DOIUrl":"10.1016/j.ejpsy.2024.100284","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Growing evidence suggests that the feeling of loneliness correlates positively with the incidence of dementia, motivating our study of their longitudinal association. Additionally, we sought potential mediators of the association, following the hypotheses that lonely individuals are prone to greater stress and follow less healthy lifestyles, therefore are at greater risk of developping dementia.</div></div><div><h3>Methods</h3><div>Using longitudinal cohort data from the UK Biobank, we conducted a logistic regression analysis with loneliness as exposure and dementia diagnosis as outcome, and progressively adjusted for putative confounders. In addition, we investigated through mediation models the respective contributions of physiological and behavioural factors to the association between loneliness and dementia diagnosis.</div></div><div><h3>Results</h3><div>The logistic regression models illustrated a significant positive association between loneliness and a subsequent dementia diagnosis, overall indicating a higher odds of developing dementia in the lonely population (Adjusted Odds Ratio (AOR) = 1.39; 95 % (Confidence Interval) CI 1.24 – 1.56, <em>P</em> &lt; 0.001). The mediation models highlighted that there was very little evidence of mediation by hypertension and unhealthy behaviours, respectively explaining 1 % and 2 % of the effect of loneliness on dementia risk. No indication of mediation was seen between baseline CRP-levels and all-cause dementia. Every mediation model described a positive correlation between loneliness and each potential mediating factor, illustrating the widespread negative impact of loneliness on health.</div></div><div><h3>Conclusion</h3><div>Our findings confirm the association between loneliness and risk of dementia. They show minimal mediation by hypertension and unhealthy behaviours, highlighting the need for investigation into other potential mediators as targets for modification.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100284"},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a linoleic acid derivative in elderly female patients with schizophrenia from rural regions using untargeted metabolomics","authors":"Bo Pan ,&nbsp;Li Qu ,&nbsp;Chuan-Lan Wang ,&nbsp;Jianjun Weng ,&nbsp;Jian-Feng Yu ,&nbsp;Yanqing Liu ,&nbsp;Xing-Chen Wang","doi":"10.1016/j.ejpsy.2024.100285","DOIUrl":"10.1016/j.ejpsy.2024.100285","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Schizophrenia is a chronic and severe mental illness, affecting a large number of general populations. It was well documented that metabolic dysregulation is associated with schizophrenia. In order to define reliable peripheral biomarkers for schizophrenia in patients with specific age, sex, and locations, plasma metabolic profiling of elderly female schizophrenic patients in rural regions was investigated in this study.</div></div><div><h3>Methods</h3><div>A total of 20 female schizophrenic patients (average age: 68.65 ± 4.11) and 20 matched healthy controls were recruited. An untargeted metabolomics analysis was performed with their plasma samples of the participants. Differentially-expressed metabolites (DEMs) were identified, followed by a pathway enrichment analysis to reveal related signalling pathways. Then, machine learning analyses, including random forest (RF) and support vector machines-recursive feature elimination (SVM-RFE), were implemented to determine signature metabolite(s).</div></div><div><h3>Results</h3><div>A total number of 2764 metabolites were identified, among which 61 DEMs were identified, including 38 down-regulated and 23 up-regulated metabolites. The enrichment analysis showed that glycerophospholipid metabolism and sphingolipid signalling pathway were the most significantly affected pathways. The ROC analysis indicated that metabolites belonging to the class of fatty acyls have higher power to discriminate schizophrenia. Finally, a linoleic acid derivative (Dg(16:0/18:2(9z,12z)/0:0)[Iso2]) was revealed as signature metabolite by the RF and SVM-RFE machine learning analyses.</div></div><div><h3>Conclusion</h3><div>The present study investigated the plasma metabolic profiling of elderly female patients with schizophrenia and identified a peripheral linoleic acid derivative that might help discriminate schizophrenia and develop specific treatment strategies for elderly female patients in rural regions.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100285"},"PeriodicalIF":2.5,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation study for the individual recovery outcomes counter (I.ROC) in a Spanish population.","authors":"José A. Garrido-Cervera ,&nbsp;María I. Ruiz-Granados ,&nbsp;Antonio I. Cuesta-Vargas ,&nbsp;Antonio J. Sánchez-Guarnido","doi":"10.1016/j.ejpsy.2024.100287","DOIUrl":"10.1016/j.ejpsy.2024.100287","url":null,"abstract":"<div><h3>Background and Objective</h3><div>To improve mental health recovery, it is necessary to have validated instruments. At present, however, there is a lack of valid instruments capable of measuring the recovery process in Spanish-speaking populations. The objective of this study was therefore to translate, culturally adapt and validate the Individual Recovery Outcomes Counter (I.ROC) for use in Spanish populations.</div></div><div><h3>Methods</h3><div>The methodology applied was that recommended for cultural adaptations of questionnaires. It included the following phases: translation, back translation, cultural adaptation and understandability analysis. To assess its psychometric properties, the translated version of the I.ROC was administered to 307 people with severe mental disorders (SMDs).</div></div><div><h3>Results</h3><div>The questionnaire's internal consistency was satisfactory (Cronbach's alpha = 0.894). Its stability over time was also appropriate, with no significant differences being found in any of the items in the two evaluations. Concurrent validity with the Recovery Assessment Scale (RAS-24) was also acceptable (<em>r</em> = 0.663 <em>p</em> &lt; 0.001). The exploratory factor analysis (EFA) results were concordant with a division into the 4 original factors, but also compatible with two or even with one single general factor.</div></div><div><h3>Conclusion</h3><div>The results of the study suggest that the Spanish version of the I.ROC is a valid, reliable instrument for charting recovery in people with mental disorders (MD).</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100287"},"PeriodicalIF":2.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143172736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of communication and social support in suicidal behaviour in adults aged between 18–40 years: A systematic review","authors":"Noelia Lucía Martínez-Rives ,&nbsp;María Pilar Martín Chaparro ,&nbsp;Yasuhiro Kotera ,&nbsp;Bibha Dhungel ,&nbsp;Stuart Gilmour","doi":"10.1016/j.ejpsy.2024.100266","DOIUrl":"10.1016/j.ejpsy.2024.100266","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Social support and quality communication are crucial in suicide prevention. This systematic review aimed to identify and summarize the research on the link between these variables and suicidal behavior in adults, and their differences depending on gender.</div></div><div><h3>Methods</h3><div>The Web of Science, Scopus and PsycInfo databases were searched from January 2012 to November 2022 using the terms [(suicide* OR “deliberate self-harm”* OR self- injur* OR “suicidal behavio”*) AND (\"social support\" OR \"interpersonal relationship\") AND (communication)]. Articles published in a peer-reviewed academic journal, written in English, with participants between 18 and 40 years old, assessing communication and/or social support were included.</div></div><div><h3>Results</h3><div>Finally, we included 12 articles. We identified characteristics such as not perceiving social networks as a helpful resource, or difficulties in understanding the messages. Also, the COVID-19 pandemic, highlighted the role that technology played in social support for the most vulnerable people. Communication difficulties of the individual with greater risk for suicide, showed the importance of social support and seeking help.</div></div><div><h3>Conclusions</h3><div>The community can contribute in suicide prevention by reducing the stigma surrounding mental illness and suicide through effective communication.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 1","pages":"Article 100266"},"PeriodicalIF":2.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of 5-HTT, COMT, and BDNF functional polymorphisms and their interaction with parental bonding in attachment anxiety, among adults with personality disorders","authors":"Leire Erkoreka ,&nbsp;Iker Zamalloa ,&nbsp;Pedro Muñoz ,&nbsp;Santiago Rodriguez ,&nbsp;Aurora Arrue ,&nbsp;Miguel Angel Gonzalez-Torres","doi":"10.1016/j.ejpsy.2024.100270","DOIUrl":"10.1016/j.ejpsy.2024.100270","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Attachment is the tendency of human beings to create strong affective bonds towards specific figures, and has been described as a general vulnerability factor to diverse forms of psychopathology. Although attachment research has not tended to emphasize genetic contribution, heritability is estimated at 36–45 %. We explored the association between <em>5-HTTLPR, COMT</em> Val158Met and <em>BDNF</em> Val66Met functional polymorphisms with attachment dimensions, as well as the gene-environment interaction, considering the perceived parental rearing styles, with both a vulnerability and a differential susceptibility approach.</div></div><div><h3>Methods</h3><div>150 outpatients with a cluster B personality disorder participated in the study. Attachment was assessed using Experiences in Close Relationships-Revised and rearing styles by means of the Parental Bonding Instrument. Genotypes were analyzed using saliva samples. Statistical analyses were carried out with general linear models.</div></div><div><h3>Results</h3><div><em>COMT</em> ValVal homozygotes and <em>BDNF</em> Met-carriers were associated with significantly higher scores in attachment anxiety (COMT: ValVal 4.95±1.25 vs Met-carriers 4.42±1.30, <em>t</em>=-2.096, <em>p</em>=0.038; BDNF: ValVal 4.38±1.31 vs Met-carriers 4.95±1.24, <em>t</em> = 2.833, <em>p</em>=0.005). From a differential susceptibility approach, plasticity genotypes were identified for the three functional polymorphisms, observing significant interactions with parental overprotection and differential outcomes in relation to attachment anxiety. No associations or interactions were found with regard to attachment avoidance and the care dimension.</div></div><div><h3>Conclusion</h3><div>Our results suggest that there are individuals more susceptible to rearing experiences in terms of adult attachment outcomes, which probably also implies a greater potential to benefit from environmental and psychotherapeutic interventions.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 1","pages":"Article 100270"},"PeriodicalIF":2.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142701756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}