European Journal of Psychiatry最新文献

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Timing of antidepressant initiation postpartum and maternal mental health outcomes up to 18 months after childbirth 产后开始服用抗抑郁药的时间和分娩后18个月的产妇心理健康结果
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-03-30 DOI: 10.1016/j.ejpsy.2026.100352
Zeenat F Chatha , Nhung TH Trinh , Sina Rostami , Veerle Bergink , Alexis Carson , Per Magnus , Angela Lupattelli
{"title":"Timing of antidepressant initiation postpartum and maternal mental health outcomes up to 18 months after childbirth","authors":"Zeenat F Chatha ,&nbsp;Nhung TH Trinh ,&nbsp;Sina Rostami ,&nbsp;Veerle Bergink ,&nbsp;Alexis Carson ,&nbsp;Per Magnus ,&nbsp;Angela Lupattelli","doi":"10.1016/j.ejpsy.2026.100352","DOIUrl":"10.1016/j.ejpsy.2026.100352","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Evidence on postpartum antidepressant effectiveness is limited. We sought to determine the association between different timings of antidepressant initiation within the 0–6 months postpartum and mental outcomes at 6- and 18-months following childbirth.</div></div><div><h3>Methods</h3><div>Using data from the Norwegian Mother, Father and Child Cohort Study (MoBa) linked to a sub-sample of MoBa Genetics, we included 1146 women with psychiatric history before and/or during early pregnancy: 154 (13.4%) antidepressant initiators in the 0–6 months postpartum (37.0% within 0–3, and 63.0% within 4–6 months), and 992 (86.6%) with unmedicated new mental illness episode within same period. Depression/anxiety symptom outcomes at 6 and 18 months postpartum were self-reported. To control for measured confounding, we fit linear and modified Poisson models using overlap weighting, overall and stratified by polygenic score for antidepressant response.</div></div><div><h3>Results</h3><div>Antidepressant initiators within 0–3 months postpartum had reduced severity of depression/anxiety symptoms at 6, but not at 18 months postpartum, compared with unmedicated women (weighted mean difference (MD): -0.23, 95% CI = -0.39, -0.06) and a 44% lower risk of having active, clinically relevant depressive/anxiety symptoms at 6 months (weighted RR= 0.56, 95% CI = 0.35, 0.91). No association was observed for initiation at 4–6 months postpartum at the 6-month assessment. The associations were evident only among women having high polygenic score for positive antidepressant response (weighted MD: -0.50, 95% CI: -0.84, -0.16), and that persisted at 18 months.</div></div><div><h3>Conclusions</h3><div>Initiation of antidepressant in first 3 months postpartum, but not in months 4–6, is associated with reduced severity of depression/anxiety symptoms at 6 months post-delivery. Effects were most evident among women with higher polygenic scores; however, these findings are exploratory and warrant larger studies.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100352"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147600146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of depression and anxiety over ten years in São Paulo: trends and associated factors before, during and after the COVID-19 pandemic 圣保罗十年来抑郁和焦虑的流行:COVID-19大流行之前、期间和之后的趋势和相关因素
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-05-11 DOI: 10.1016/j.ejpsy.2026.100353
Danilo Dias Santana , Andreia Alexandra Machado Miranda , Michele Santos da Cruz , Alex Antonio Florindo
{"title":"Prevalence of depression and anxiety over ten years in São Paulo: trends and associated factors before, during and after the COVID-19 pandemic","authors":"Danilo Dias Santana ,&nbsp;Andreia Alexandra Machado Miranda ,&nbsp;Michele Santos da Cruz ,&nbsp;Alex Antonio Florindo","doi":"10.1016/j.ejpsy.2026.100353","DOIUrl":"10.1016/j.ejpsy.2026.100353","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Depression and anxiety are leading causes of disability worldwide, however longitudinal data from low- and middle-income countries (LMICs) are scarce. This study aimed to examine trends and associated factors of depression and anxiety over a 10-year period in a Brazilian urban cohort.</div></div><div><h3>Methods</h3><div>Data from the prospective cohort ‘Health Survey of Sao Paulo: Physical Activity and Environment’ were used. Participants (n = 978) were assessed in 2014-15, 2020-21, and 2023-24. Sociodemographic, health and physical activity-related characteristics, as well as self-reported measures of depression and anxiety, were investigated through a structured questionnaire. Associations were examined using hierarchical logistic regression models.</div></div><div><h3>Results</h3><div>The prevalence of depression increased from 4.2 % in 2014-15 to 15.3 % in 2023-24, while anxiety increased from 10.1 % to 28.9 %. Women consistently showed three- to fourfold higher odds of both mental health conditions compared to men. Poor sleep quality was strongly associated with two- to fivefold higher odds depression and anxiety across waves. Presence of comorbidities and obesity were also associated with higher depression and anxiety prevalences. Leisure-time physical activity was inversely associated with depression in 2014-15. Participants who used bicycles for transportation were the only subgroup in which depression and anxiety prevalence did not increase significantly.</div></div><div><h3>Conclusions</h3><div>This 10-year cohort study highlights a substantial increase in depression and anxiety in São Paulo. The protective associations of physical activity with mental health conditions reinforces the importance of promoting active lifestyles. The longitudinal design of the study and recent data collection in 2023-24 offer updated and representative insights for LMICs.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100353"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147950807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Two exploratory studies to investigate the role of self and emotional dysregulation in borderline personality disorder 两项探讨自我和情绪失调在边缘型人格障碍中的作用的探索性研究
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-02-12 DOI: 10.1016/j.ejpsy.2026.100347
Joaquim Soler , Luis Borao , Carlos Schmidt , David Martinez-Rubio , Ausiàs Cebolla , Jesús Montero-Marin , Javier García-Campayo , Santiago Gascón-Santos , Juan C. Pascual
{"title":"Two exploratory studies to investigate the role of self and emotional dysregulation in borderline personality disorder","authors":"Joaquim Soler ,&nbsp;Luis Borao ,&nbsp;Carlos Schmidt ,&nbsp;David Martinez-Rubio ,&nbsp;Ausiàs Cebolla ,&nbsp;Jesús Montero-Marin ,&nbsp;Javier García-Campayo ,&nbsp;Santiago Gascón-Santos ,&nbsp;Juan C. Pascual","doi":"10.1016/j.ejpsy.2026.100347","DOIUrl":"10.1016/j.ejpsy.2026.100347","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Emotion dysregulation is traditionally considered a core characteristic of Borderline Personality Disorder (BPD), while alterations in self-concept are often viewed as secondary to emotional dysregulation. \"Delusion of Me\" (DoM) is a unidimensional construct comprising three domains: acceptance, decentering, and non-attachment. It could be considered closely related to the concept of “self-as-content” and may potentially serve as a measure of this dimension of identity. Across two exploratory studies, the role of DoM as a measure of self-disturbance applied to BPD was investigated.</div></div><div><h3>Method</h3><div><em>Study 1:</em> A descriptive study comparing disturbances in self-concept (measured by DoM index) and emotional dysregulation in 127 individuals with BPD and 283 non-clinical comparison participants. Correlations between DoM scores and other clinical variables in BPD were also analyzed. <em>Study 2:</em> An exploratory intervention study comparing changes in DoM scores after participation in a mindfulness skills training (<em>n</em> = 32) with a control group (<em>n</em> = 31) receiving interpersonal effectiveness training.</div></div><div><h3>Results</h3><div>Individuals with BPD exhibited significantly lower DoM scores compared to non-clinical controls. DoM index correlated with borderline symptoms and emotional overproduction, independent of emotional dysregulation. Additionally, mindfulness training resulted in a significant increase in DoM scores compared to interpersonal effectiveness intervention. Post-intervention, changes in the DoM index predicted improvements in borderline symptoms, independent of changes in emotion dysregulation.</div></div><div><h3>Conclusion</h3><div>These findings support DoM as a promising transdiagnostic marker of self-disturbances, related to identification, in BPD and suggesting that mindfulness-based interventions may facilitate therapeutic change in part by transforming this component of the self beyond emotional regulation.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100347"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex differences in the efficacy of cognitive behavioral therapy for adults with attention-deficit/hyperactivity disorder 成人注意缺陷/多动障碍认知行为治疗效果的性别差异
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-02-07 DOI: 10.1016/j.ejpsy.2026.100345
Juan Jesús Crespín , Montse Corrales , Vanesa Richarte , Gemma Parramón , Santiago Biel , Ferran Mestres , Carolina Ramos-Sayalero , Pol Ibáñez , Gemma Nieva , Carla Torrent , Derek Clougher , Christian Fadeuilhe , Silvia Amoretti , Josep Antoni Ramos-Quiroga
{"title":"Sex differences in the efficacy of cognitive behavioral therapy for adults with attention-deficit/hyperactivity disorder","authors":"Juan Jesús Crespín ,&nbsp;Montse Corrales ,&nbsp;Vanesa Richarte ,&nbsp;Gemma Parramón ,&nbsp;Santiago Biel ,&nbsp;Ferran Mestres ,&nbsp;Carolina Ramos-Sayalero ,&nbsp;Pol Ibáñez ,&nbsp;Gemma Nieva ,&nbsp;Carla Torrent ,&nbsp;Derek Clougher ,&nbsp;Christian Fadeuilhe ,&nbsp;Silvia Amoretti ,&nbsp;Josep Antoni Ramos-Quiroga","doi":"10.1016/j.ejpsy.2026.100345","DOIUrl":"10.1016/j.ejpsy.2026.100345","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Cognitive Behavioral Therapy (CBT) is an effective adjunctive treatment for Attention-Deficit/Hyperactivity Disorder (ADHD). This study examined sex differences in the efficacy of a brief 6-session CBT program versus a traditional 12-session format, combined with stable pharmacotherapy, in adults with ADHD.</div></div><div><h3>Methods</h3><div>A total of 81 adults (58 % male; 41.27 ± 9.26 years) were randomly assigned to 6- or 12-session CBT. ADHD symptoms, psychopathology, and functioning were assessed at baseline, post-treatment, and 3- and 6-month follow-up. Mixed-effects models analyzed interactions between time, treatment group, and sex.</div></div><div><h3>Results</h3><div>At baseline, females exhibited greater symptom severity (p = 0.019), higher inattention (p &lt; 0.001), and more pronounced impairments (p = 0.004). CBT led to significant clinical improvements regardless of sex. A significant time-by-sex interaction emerged for inattention (CAARS:O:L, p = 0.043), although it did not remain significant after adjusting for baseline severity. Regarding time × group × sex interactions, females in the 6-session group showed smaller reductions in clinical severity during follow-up (CGI-S, p = 0.047); however, this effect was no longer statistically significant after controlling for baseline ADHD severity. Findings should be interpreted with caution given the limited female sample at follow-up and the significant influence of initial symptom burden on long-term trajectories.</div></div><div><h3>Conclusions</h3><div>CBT improves ADHD symptoms and related impairments in adults, with comparable overall benefits across sexes. Treatment response follow-up differences were better explained by baseline severity and treatment intensity rather than sex-specific differences.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100345"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146135651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Baseline severity, not sex, should guide CBT dose in adult ADHD 基线严重程度,而不是性别,应该指导成人ADHD的CBT剂量
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-04-19 DOI: 10.1016/j.ejpsy.2026.100354
Lukasz Szarpak , Iwona Niewiadomska , Michal Pruc
{"title":"Baseline severity, not sex, should guide CBT dose in adult ADHD","authors":"Lukasz Szarpak ,&nbsp;Iwona Niewiadomska ,&nbsp;Michal Pruc","doi":"10.1016/j.ejpsy.2026.100354","DOIUrl":"10.1016/j.ejpsy.2026.100354","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100354"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147740394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations between objective measures of physical activity, self-reported fatigue, and fatigue catastrophizing in individuals with schizophrenia 精神分裂症患者体力活动的客观测量、自我报告的疲劳和疲劳灾变之间的关系
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-05-05 DOI: 10.1016/j.ejpsy.2026.100358
Stéphane Raffard , Yasmine Laraki , Erica Fongaro , Delphine Capdevielle
{"title":"Associations between objective measures of physical activity, self-reported fatigue, and fatigue catastrophizing in individuals with schizophrenia","authors":"Stéphane Raffard ,&nbsp;Yasmine Laraki ,&nbsp;Erica Fongaro ,&nbsp;Delphine Capdevielle","doi":"10.1016/j.ejpsy.2026.100358","DOIUrl":"10.1016/j.ejpsy.2026.100358","url":null,"abstract":"<div><h3>Background and Aims</h3><div>Individuals with schizophrenia exhibit markedly low levels of physical activity and prolonged inactivity, contributing to increased cardiometabolic risk and reduced life expectancy. Fatigue is highly prevalent in schizophrenia and frequently reported as a major barrier to physical activity; however, its relationship with objectively measured activity remains poorly understood. In particular, the role of maladaptive cognitive appraisals of fatigue has not been examined. This exploratory study investigated associations between self-reported fatigue, fatigue catastrophizing, and objectively measured physical activity in individuals with schizophrenia compared with non-clinical controls.</div></div><div><h3>Methods</h3><div>Sixty participants (27 individuals with schizophrenia and 33 non-clinical controls), matched on age, sex, and body mass index, wore a tri-axial wrist accelerometer continuously for seven days. Physical activity and inactivity were derived using standardized processing pipelines. Fatigue was assessed with the Multidimensional Fatigue Inventory and fatigue catastrophizing with the Fatigue Catastrophizing Scale. Associations between fatigue measures, physical activity, and clinical symptoms were examined.</div></div><div><h3>Results</h3><div>Compared with controls, individuals with schizophrenia showed significantly lower levels of light, moderate, and vigorous physical activity, alongside higher fatigue, fatigue catastrophizing, and depressive symptoms. In the schizophrenia group, fatigue severity was not associated with objectively measured physical activity. In contrast, higher fatigue catastrophizing was associated with lower moderate physical activity and reduced step count. Fatigue severity was associated with depressive and negative symptoms, but not with physical activity.</div></div><div><h3>Conclusion</h3><div>These findings suggest a dissociation between fatigue severity and actual physical activity behavior in schizophrenia and highlight fatigue catastrophizing as a key cognitive factor linked to reduced activity.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100358"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147849645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mixed-methods analysis of formulations in functional neurological disorder 功能性神经障碍制剂的混合方法分析
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-04-01 Epub Date: 2026-02-13 DOI: 10.1016/j.ejpsy.2026.100348
Myles Gutkin , Richard A Kanaan , Richard J Brown
{"title":"Mixed-methods analysis of formulations in functional neurological disorder","authors":"Myles Gutkin ,&nbsp;Richard A Kanaan ,&nbsp;Richard J Brown","doi":"10.1016/j.ejpsy.2026.100348","DOIUrl":"10.1016/j.ejpsy.2026.100348","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Functional Neurological Disorder (FND) is a relatively common neuropsychiatric condition characterised by disabling or distressing, but potentially reversible, neurological symptoms. There are no well-validated treatments, despite emerging evidence for several psychotherapies. A formulation is a set of explanatory hypotheses answering the question ‘why does this patient suffer from this problem at this time?’ This study examined the formulations of adults with FND who were treated with Shared Individual Formulation Therapy (SIFT). SIFT uses clinical history-taking and hypothesis-refinement over several sessions to collaboratively formulate how symptoms have emerged in the context of the patient’s life experience, to identify relevant vulnerabilities and coping strategies. A shared individual formulation is co-written and verified with each participant to ensure it represents their experience accurately. Our objective was to explore the patterns and associations in these formulations.</div></div><div><h3>Methods</h3><div>We extracted the formulations from twenty-four letters generated during a prospective, open-label trial of SIFT for FND. Framework analysis was used to identify the key features (‘exposures’, ‘schemas’, ‘activations’ and ‘mechanisms’) within each formulation. Subgroups identified using hierarchical clustering were compared statistically across characteristics, therapy ratings and outcome scores.</div></div><div><h3>Results</h3><div>Three clusters were identified. Two were characterised by overvigilance and body focus (<em>n</em> = 10), and one was characterised by dissociation and other directedness (<em>n</em> = 14). There was some indication of possible differences in treatment response, but numbers were too small to draw firm conclusions.</div></div><div><h3>Conclusion</h3><div>Findings support the psychological heterogeneity of adults with FND. Analysis of formulations can be used to identify clinically distinct subgroups.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 2","pages":"Article 100348"},"PeriodicalIF":1.5,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146172519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disentangling empathy for psychological and physical pain in borderline personality disorder: the interplay with clinical features and emotional competence 边缘型人格障碍心理和生理疼痛的共情解缠:与临床特征和情绪能力的相互作用
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.ejpsy.2025.100339
Margherita Bechi , Martin Brüne , Giulia Agostoni , Roberta Bortolla , Maria Vittoria Bongiorno , Gea Spada , Martina Ceresi , Anna Rosini , Laura Sforzini , Marta Bosia , Roberto Cavallaro , Vera Flasbeck
{"title":"Disentangling empathy for psychological and physical pain in borderline personality disorder: the interplay with clinical features and emotional competence","authors":"Margherita Bechi ,&nbsp;Martin Brüne ,&nbsp;Giulia Agostoni ,&nbsp;Roberta Bortolla ,&nbsp;Maria Vittoria Bongiorno ,&nbsp;Gea Spada ,&nbsp;Martina Ceresi ,&nbsp;Anna Rosini ,&nbsp;Laura Sforzini ,&nbsp;Marta Bosia ,&nbsp;Roberto Cavallaro ,&nbsp;Vera Flasbeck","doi":"10.1016/j.ejpsy.2025.100339","DOIUrl":"10.1016/j.ejpsy.2025.100339","url":null,"abstract":"<div><h3>Background and objectives</h3><div><strong>:</strong> Patients with Borderline Personality Disorder (BPD) often struggle in social interactions, exhibiting altered empathy and biased emotion recognition. Understanding how these aspects intertwine and relate to BPD symptoms remains unclear. This study aims at evaluating the ability to perceive both psychological and physical pain from a third-person and first-person perspective in BPD people and healthy controls, as well as to explore the interplay with childhood traumas, subjective empathy, alexithymia, emotion dysregulation and severity of symptoms.</div></div><div><h3>Methods</h3><div><strong>:</strong> We utilized the 'Social Interaction Empathy Task' on an Italian sample (49 BPD patients, 52 healthy controls) to explore empathy for physical and psychological pain. We also evaluated emotion recognition alongside traits like alexithymia, childhood trauma, parenting style, dissociation, and impulsivity.</div></div><div><h3>Results</h3><div><strong>:</strong> BPD patients perceived psychologically painful and neutral social situations as more distressing than controls, especially in the first-person perspective. A linear regression analysis revealed that 'Difficulty Describing Feelings' (DDF) subscale of the Toronto Alexithymia Scale (TAS-20) predicted ratings for psychologically painful images from a third-person view. Additionally, BPD patients frequently misinterpreted happy and neutral faces. We also observed correlations between emotion recognition and adverse childhood experiences, parenting style, and symptom severity.</div></div><div><h3>Conclusion</h3><div><strong>:</strong> These findings suggest altered empathy for psychological pain in BPD patients, partly influenced by challenges in articulating emotions.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 1","pages":"Article 100339"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145876951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heterogeneity in the association between CYP2D6 genotype and antipsychotic-induced extrapyramidal symptoms: A systematic review CYP2D6基因型与抗精神病药物诱导的锥体外系症状相关性的异质性:一项系统综述
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-01-01 Epub Date: 2026-01-02 DOI: 10.1016/j.ejpsy.2025.100338
Antonina Luca , Maria Luca , Paolo Olgiati , Alessandro Serretti
{"title":"Heterogeneity in the association between CYP2D6 genotype and antipsychotic-induced extrapyramidal symptoms: A systematic review","authors":"Antonina Luca ,&nbsp;Maria Luca ,&nbsp;Paolo Olgiati ,&nbsp;Alessandro Serretti","doi":"10.1016/j.ejpsy.2025.100338","DOIUrl":"10.1016/j.ejpsy.2025.100338","url":null,"abstract":"<div><h3>Introduction</h3><div>Cytochrome‑P450 2D6 (CYP2D6) activity modulates the biotransformation of many antipsychotics and neuroactive endobiotics. Functional polymorphisms yielding poor (PM), intermediate (IM), normal (NM) or ultrarapid (UM) metabolic phenotypes could therefore influence vulnerability to extrapyramidal symptoms (EPS). Aim of the present review was to critically summarize the evidence linking CYP2D6 genotype with antipsychotic‑induced EPS.</div></div><div><h3>Methods</h3><div>A systematic search of PubMed, MEDLINE and EBSCO (1 January 1997 – 28 April 2025) identified studies that: (i) examined CYP2D6 genotype or phenotype in relation to antipsychotic exposure, (ii) quantitatively assessed EPS, and (iii) enrolled ≥ 10 participants.</div></div><div><h3>Results</h3><div>Eighteen studies (7 prospective cohorts, 10 cross‑sectional studies, 1 randomized controlled trial; total n= 2037 participants) met inclusion criteria. Typical antipsychotics—particularly haloperidol and zuclopenthixol—dominated the exposure profile (64 % of participants). Eleven studies reported a genotype‑EPS association, consistently showing greater EPS prevalence or severity in PM and IM carriers. Reported odds ratios for EPS across included studies ranged ∼2–5 for PM/IM vs EM/UM. Risperidone and haloperidol were the antipsychotics most frequently associated with EPS. Null findings were primarily reported by studies devoid of PM genotypes and enrolling adolescent cohorts receiving second‑generation antipsychotics.</div></div><div><h3>Conclusion</h3><div>Some studies summarized in the present review supported the role of CYP2D6 genotype in the occurrence of EPS in patients treated with antipsychotics, particularly with high-potency D₂ antagonists. Prospective, genotype‑stratified trials that incorporate concomitant inhibitors/inducers, polygenic scores and pharmacodynamic modifiers are still required before cost‑effective implementation algorithms can be finalized.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 1","pages":"Article 100338"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145876952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Translating human rights into perinatal mental health policy in Spain 将人权转化为西班牙的围产期心理健康政策
IF 1.5 4区 医学
European Journal of Psychiatry Pub Date : 2026-01-01 Epub Date: 2026-01-28 DOI: 10.1016/j.ejpsy.2026.100344
Rocío Paricio-del-Castillo
{"title":"Translating human rights into perinatal mental health policy in Spain","authors":"Rocío Paricio-del-Castillo","doi":"10.1016/j.ejpsy.2026.100344","DOIUrl":"10.1016/j.ejpsy.2026.100344","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"40 1","pages":"Article 100344"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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