European Journal of Psychiatry最新文献

{"title":"Association between neutrophil-to-lymphocyte ratio and bipolar disorder: A systematic review and meta-analysis","authors":"Ling Gui ,&nbsp;Haiyan Yu ,&nbsp;Yuxin Wei ,&nbsp;Qichao Huang ,&nbsp;Yuyao Liu ,&nbsp;Yixiao Fu","doi":"10.1016/j.ejpsy.2025.100308","DOIUrl":"10.1016/j.ejpsy.2025.100308","url":null,"abstract":"<div><h3>Objective</h3><div>The neutrophil-to-lymphocyte ratio (NLR), a systemic indicator of inflammation and stress, shows inconsistent associations with bipolar disorder (BD). This meta-analysis will investigate NLR's diagnostic, prognostic, and therapeutic relevance in BD.</div></div><div><h3>Methods</h3><div>A systematic search across PubMed, Embase, Web of Science, PsycINFO, and Cochrane Library, using key terms ‘bipolar disorder’, ‘neutrophils’, ‘lymphocytes’, and ‘ratio’ yielded 31 studies assessed via Newcastle-Ottawa Scale. Sensitivity analyses, subgroup analyses and publication bias assessments were conducted to explore heterogeneity sources and result stability.</div></div><div><h3>Results</h3><div>The NLR values in BDs were significantly higher than those in healthy controls (HCs) (standardized mean difference [SMD] = 0.51, 95 % confidence interval [CI]: 0.40–0.62, <em>p</em> &lt; 0.0001; odds ratio [OR] = 1.87, 95 % CI: 1.27–2.74, <em>p</em> = 0.001). The association was most pronounced between bipolar mania (BDM) and HC (SMD = 0.67, 95 % CI: 0.57–0.76, <em>p</em> &lt; 0.0001, I² = 47 %). Additionally, BDM exhibited higher NLR than bipolar depression (BDD) and bipolar patients in euthymic episode (BDE) (SMD = 0.22, 95 % CI: 0.07–0.38, <em>p</em> = 0.04, I² = 42 %; SMD = 0.31, 95 % CI: 0.15–0.48, <em>p</em> = 0.0001, I² = 60 %, respectively). No significant differences were observed between BDD and HC (SMD = 0.30, 95 % CI: -0.05–0.64, <em>p</em> = 0.09). Subgroup analyses suggested that age may influence the association between NLR and BD.</div></div><div><h3>Conclusion</h3><div>An elevated NLR value is found in BD, particularly in BDM. However, the difference between BDD and HC is not statistically significant. NLR may be a potent biomarker for the identification and evaluation of BD.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100308"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in 4466 mood disorder patients","authors":"Alessandro Miola ,&nbsp;Leonardo Tondo ,&nbsp;Ross J. Baldessarini","doi":"10.1016/j.ejpsy.2025.100303","DOIUrl":"10.1016/j.ejpsy.2025.100303","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Characteristics of women and men with bipolar disorder (BD) or major depressive disorder (MDD) have been described with inconsistent findings requiring additional assessment.</div></div><div><h3>Methods</h3><div>We evaluated clinical characteristics in 4466 consecutive, extensively evaluated mood disorder patients (1491 BD, 2975 MDD; 2795 women, 1671 men) using standard bivariate statistics and multivariable logistic regression modeling.</div></div><div><h3>Results</h3><div>Diagnosis of MDD occurred 2.28- (women) to 1.62- (men) times more than BD, but prevalence of type II BD (BD2) and type I (BD1) did not differ by gender. BD women had more familial mood disorders, early sexual abuse, anxious or cyclothymic temperament, depressive first episodes, depression–[hypo]mania–interval (DMI) and rapid-cycling course, as well as greater %-time depressed in prospective follow-up, with more suicide attempts but fewer suicides than BD men. BD women also showed more co-occurring anxiety disorder, eating disorder and medical comorbidity, including metabolic disorders and cancer, but lower rates of ADHD and substance-abuse than BD men. MDD women experienced more religious activity, sexual abuse, anxious or cyclothymic temperament, co-occurring eating disorder and medical comorbidity as well as less substance-abuse and ADHD than MDD men but did not differ from men in measures of prospective morbidity.</div></div><div><h3>Conclusions</h3><div>Many characteristics were selectively associated with women with mood disorders, but prospective morbidity was similar by gender except for greater %-time depressed among BD women. Limited ethnic diversity and treatment in specialized centers may affect generalizability of these findings to other settings.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100303"},"PeriodicalIF":2.5,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological interventions to improve cognitive biases in people with schizophrenia: A systematic review","authors":"Marcel Gratacós-Torras ,&nbsp;Esther Pousa ,&nbsp;Susana Ochoa ,&nbsp;Josep Manel Santos","doi":"10.1016/j.ejpsy.2025.100304","DOIUrl":"10.1016/j.ejpsy.2025.100304","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with schizophrenia commonly exhibit cognitive biases that are related to the disorder's symptoms.</div></div><div><h3>Objective</h3><div>To review the current evidence on the characteristics and efficacy of psychological interventions targeting cognitive biases in individuals with schizophrenia.</div></div><div><h3>Method</h3><div>Systematic review registered in PROSPERO. A bibliographic search was conducted in PsycINFO, PubMed, Scopus, and Web of Science up to January 2024. The search focused on quantitative studies using the following keyword sequence: (schizophreni* OR psychosis OR psychoses OR psychotic*) AND (cogniti* OR think*) AND (bias* OR error*) AND (treatment OR therapy OR intervention OR training).</div></div><div><h3>Results</h3><div>A total of 38 studies assessed psychological interventions targeting cognitive biases in schizophrenia, with most focusing on Metacognitive Training (MCT). These interventions were found to significantly improve cognitive biases and positive symptoms, with promising effects on other symptoms,such as insight, negative symptoms, or self-esteem.</div></div><div><h3>Conclusions</h3><div>The evidence linking cognitive biases to schizophrenia symptomatology is reinforced. Additionally, it is shown that improving cognitive biases may be an important therapeutic goal in the treatment of the disorder.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100304"},"PeriodicalIF":2.5,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental illness discussion variations on X: Topic modelling and sentiment analysis","authors":"Javier Domingo-Espiñeira ,&nbsp;Andrea Varaona-Santos ,&nbsp;Francisco J. Lara Abelenda ,&nbsp;María Montero ,&nbsp;Emilio Fernandez-Egea ,&nbsp;Leticia I Muñoz-Manchado ,&nbsp;Miguel A. Ortega ,&nbsp;Melchor Álvarez-Mon ,&nbsp;Miguel Ángel Álvarez-Mon","doi":"10.1016/j.ejpsy.2025.100300","DOIUrl":"10.1016/j.ejpsy.2025.100300","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Social Media Listening has become essential for understanding societal attitudes about mental health. However, there is a lack of studies focusing on Spanish-language discussions and long-term analyses. This study aims to investigate the evolution of Spanish and English public discourse on nine psychiatric disorders over 15 years on X, identifying frequently addressed topics and associated emotions.</div></div><div><h3>Methods</h3><div>We collected and analyzed tweets in English and Spanish from 2007 to 2022, referring to nine psychiatric disorders (autism, ADHD, schizophrenia, bipolar disorder, depressive episode, anxiety, addictions, insomnia, and suicide). Advanced topic modeling and sentiment analysis were applied.</div></div><div><h3>Results</h3><div>The study revealed differences in tweet volumes across disorders and languages. Anxiety was the most prevalent term in both Spanish and English tweets. Spanish discussions emphasized insomnia and suicide attempts, while English tweets highlighted autism and schizophrenia. Tweets about bipolar disorder, depressive episode, and addictions were consistently low in both languages. Over time, Spanish tweets on insomnia, anxiety, and suicide attempts increased, while English tweets on autism, anxiety, suicide attempts, and schizophrenia spiked in 2018 and 2019. Topic modeling indicated that Spanish tweets focused on personal experiences with mental disorders and their impact on life, primarily associated with anger, fear, sadness, and joy. English tweets centered on social awareness and advocacy, eliciting fear, followed by treatment and prevention, associated with fear and sadness.</div></div><div><h3>Conclusions</h3><div>Despite fewer discussions on X about severe mental disorders like bipolar disorder, schizophrenia, and addictions, X serves as a supportive environment for mental health discourse. Spanish-speaking users share personal experiences, fostering self-expression, while English users promote social awareness and advocacy. This highlights X's role in normalizing mental health conversations, reducing stigma, and increasing support.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100300"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scale to measure dialectical thinking from dialectical behavior therapy perspective.","authors":"Joaquim Soler ,&nbsp;Maria Arqueros ,&nbsp;Carlos Schmidt ,&nbsp;Daniela Otero ,&nbsp;Anna Soria-Madrid ,&nbsp;María José Campins ,&nbsp;Anna Catalan ,&nbsp;Elisabet Casellas ,&nbsp;Rocío Espeso ,&nbsp;Juan Carlos Pascual","doi":"10.1016/j.ejpsy.2025.100305","DOIUrl":"10.1016/j.ejpsy.2025.100305","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Dialectical thinking is a core component of dialectical behavior therapy (DBT), characterized by the synthesis of seemingly opposing ideas to develop a more comprehensive perspective. This study aimed to create a reliable and valid instrument for measuring dialectical thinking.</div></div><div><h3>Method</h3><div>We analyzed the psychometric properties of the Dialectical Thinking Scale in a mixed sample of 205 participants. Factor structure with both exploratory and confirmatory factor analyses, reliability, test-retest stability, sensitivity to change, and convergent validity were evaluated.</div></div><div><h3>Results</h3><div>The final resulting questionnaire consisted of a 5-item self-reported scale. The analyses revealed a distinct two-factor structure: \"Both Sides\" (the capacity to recognize and accept opposing perspectives as simultaneously valid, thereby fostering cognitive flexibility and reducing polarized thinking) and \"Both Sides in Me\" (the ability to integrate and accept internal contradictions). The scale exhibited high internal consistency (Cronbach's alpha = 0.81), and robust test-retest reliability (ICC = 0.82 for \"Both Sides\" and 0.64 for \"Both Sides in Me\"). The scale demonstrated satisfactory sensitivity to change after psychotherapeutic intervention and showed significant negative correlations with psychopathological symptoms.</div></div><div><h3>Conclusions</h3><div>This scale addresses a critical gap in clinical assessment tools for DBT and it holds promise for applications across mental disorders and social studies.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100305"},"PeriodicalIF":2.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143679446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Fluctuations in mental health symptoms from recruitment to baseline: implications for eligibility in clinical trials\"","authors":"Juliane Piasssechi de Bernardin Gonçalves ,&nbsp;Homero Vallada ,&nbsp;Giancarlo Lucchetti","doi":"10.1016/j.ejpsy.2025.100306","DOIUrl":"10.1016/j.ejpsy.2025.100306","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100306"},"PeriodicalIF":2.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143620541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 12-month follow-up study of self-harming behaviors in a sample of adolescents","authors":"Javier Vera-Martínez ,&nbsp;Francisco Díaz-Atienza ,&nbsp;Pablo González-Domenech ,&nbsp;Luis Gutiérrez-Rojas ,&nbsp;Sara Jiménez-Fernández","doi":"10.1016/j.ejpsy.2025.100301","DOIUrl":"10.1016/j.ejpsy.2025.100301","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100301"},"PeriodicalIF":2.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating an intervention program to reduce suicidal behavior in adolescents with psychiatric disorders: A protocol design","authors":"Veronica Fernandez-Rodrigues ,&nbsp;Wala Ayad-Ahmed ,&nbsp;Paola Marin-Santos ,&nbsp;Jose Manuel Lopez-Villatoro ,&nbsp;Alejandro de la Torre-Luque ,&nbsp;Teresa Bobes-Bascaran ,&nbsp;Jose Luis Carrasco ,&nbsp;Luis Olivares ,&nbsp;Marina Diaz-Marsa","doi":"10.1016/j.ejpsy.2025.100298","DOIUrl":"10.1016/j.ejpsy.2025.100298","url":null,"abstract":"<div><h3>Introduction</h3><div>Suicide is the leading cause of unnatural death in adolescents. In addition, between 7 and 17% of adolescents may engage in at least one suicide attempt, with prevalence being dramatically higher in adolescents with psychiatric pathology. Death by suicide is usually preceded by several attempts to take one's own life. Among the risk factors most consistently associated with suicidal intent is suicidal ideation. This study aims to evaluate the efficacy of the Self-Awareness of Mental Health (SAM) program enriching standard care, for adolescents at high suicide risk (mental disorder and high suicidal ideation).</div></div><div><h3>Methodology</h3><div>A randomized single-blind controlled clinical trial will be conducted with a sample of 116 adolescents with suicidal ideation and/or suicide attempt, referred by their psychiatrists from the Hospital Clínico San Carlos (Madrid, Spain). The cohort will be divided into two groups (an intervention group, in which the SAM intervention will be administered as an adjuvant to standard treatment; and a treatment-as-usual group). An extensive clinical assessment on risk factors for suicidal behavior and psychiatric symptoms will be applied up to four times: baseline, post (5 weeks), 3 and 6 months.</div></div><div><h3>Results</h3><div>Data collection is ongoing. This study will provide data on the effectiveness of the SAM intervention in reducing ideation, preventing the occurrence of suicide attempts, and mitigating emotional symptomatology, such as for anxiety and depression.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100298"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic evidence of increased schizophrenia risk due to antidepressant use in European and East Asian populations","authors":"Zhiqiang Du ,&nbsp;Xiangjun Zhou ,&nbsp;Qin Zhou,&nbsp;Rongrong Lu,&nbsp;Ying Jiang,&nbsp;Haohao Zhu","doi":"10.1016/j.ejpsy.2025.100302","DOIUrl":"10.1016/j.ejpsy.2025.100302","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Understanding the relationship between antipsychotic drugs (ATDs) use and schizophrenia (SCZ) is crucial. Thus, the objective is to explore the bidirectional causal relationship between ATDs use and SCZ via Two-Sample Mendelian Randomization (TSMR) analysis, aiming to offer new insights for the clinical treatment of SCZ.</div></div><div><h3>Methods</h3><div>We employed data from Genome-Wide Association Studies (GWAS) and conducted TSMR analysis using the Inverse Variance Weighted (IVW) method. The results were evaluated using P-values, OR values, and 95% Confidence Intervals (95% CI) to assess the bidirectional causal relationship.</div></div><div><h3>Results</h3><div>At the genetic level, we found a bidirectional positive correlation between European ATDs use and SCZ [OR: 1.283, 95% CI: 1.136–1.449; P = 5.73E-05] and [OR: 1.130, 95% CI: 1.082–1.180; P = 4.27E-08]. East Asian ATDs use and SCZ also showed a positive correlation [OR: 1.174, 95% CI: 1.038–1.328; P = 0.011], while no significant causal relationship was found between East Asian SCZ and ATDs use [OR: 1.004, 95% CI: 0.999–1.009; P = 0.161]. Sensitivity analysis further supported the robustness and reliability of these findings.</div></div><div><h3>Conclusion</h3><div>At the genetic level, we found that European and East Asian ATDs use may increase the risk of developing SCZ. This can help in formulating clinical medication strategies, where more caution may be needed in deciding whether to prescribe ATDs to SCZ patients. Additionally, we discovered that European SCZ might increase ATDs use, whereas no such risk was found in East Asians.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 2","pages":"Article 100302"},"PeriodicalIF":2.5,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between psychological pain and suicidal behaviour in a cohort of patients at high risk of suicide","authors":"Ana Pérez-Balaguer ,&nbsp;Inmaculada Peñuelas-Calvo ,&nbsp;Ana María de Granda-Beltrán ,&nbsp;Jimena María Merayo-Cano ,&nbsp;Berta Ezquerra ,&nbsp;Adrián Alacreu-Crespo ,&nbsp;Enrique Baca-García ,&nbsp;Alejandro Porras-Segovia","doi":"10.1016/j.ejpsy.2025.100299","DOIUrl":"10.1016/j.ejpsy.2025.100299","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Suicide is a major global public health issue. Pain, both psychological and physical, are potential risks factors for suicidal behaviour (SB). This study aims to explore the relationship between psychological and physical pain and SB in individuals at high risk of suicide.</div></div><div><h3>Methods</h3><div>This prospective cohort study included 322 participants recruited from emergency departments, psychiatric inpatient units, and outpatient mental health services in two hospitals in Madrid (Spain). Participants completed assessments at baseline and six months. Psychological and physical pain were measured using validated Visual Analog Scales (VAS). The primary outcome was the occurrence of suicidal events, documented through medical records and follow-up interviews. Kaplan-Meier survival analyses estimated the occurrence of suicidal events after 6 months of follow-up. Factors associated with suicidal events were analysed using univariate and multivariate Cox regression models to identify independent predictors of SB.</div></div><div><h3>Results</h3><div>Severe psychological pain in the previous 15 days was significantly associated with an increased risk of SB (<em>p</em> = 0.017), independently of depression severity. Younger age also emerged as a significant risk factor. No association was found between physical pain and SB.</div></div><div><h3>Conclusions</h3><div>Psychological pain is a key predictor of SB and should be a focus in suicide risk assessments. Further research is needed to improve measurement tools and develop targeted interventions in order to treat psychological pain effectively.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100299"},"PeriodicalIF":2.5,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}