Association of HSV2 infection and depression in adults: a cross-sectional study of NHANES from 2005–2016

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2025-04-18 DOI:10.1016/j.ejpsy.2025.100312

Mingbo Wei , Yi Feng , Hongyan Peng , Binbin Chen , Yifan Wu , Weiming Mao , Qing Cai , Jiajin Xu , Laibao Yang , Panpan Chen , Huimin Zheng , Licheng Yu

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引用次数: 0

Abstract

Background and objectives

Depression is a major mental system disorder, and previous studies have found an association between herpes simplex virus 2 (HSV-2) infection and depression. However, recently researches report that depression can be divided into two categories, cognitive symptoms and somatic symptoms, but the relationship between the subtypes of depression is still unknown.

Methods

We obtained NHANES data from cycles 2005–2016, and a total of 1124 depressed cases and 4253 matched controls were selected achieving a 1:4 matching ratio. Logistic regression was used to explore the association of HSV-2 infection with depression status and severity. Zero-inflated negative binomial regression was employed to assess associations between HSV-2 infection and specific cognitive/somatic symptoms of depression.

Results

HSV2 infection was positively associated with depression status (OR=1.33, 1.11∼1.59) and severity (OR=1.24, 1.05∼1.45), but these associations were only observed in female, not in male. Furtherly, result of Zero-inflated negative binomial regression suggested that HSV2 infection increased total score of somatic symptoms (RR=1.15, 1.16∼1.25) rather than cognitive symptoms in female. Moreover, HSV2 infection was related to increasing somatic symptoms, including sleeping difficulties, fatigue and appetite problems, but not any cognitive symptoms.

Conclusion

HSV-2 infection is positively associated with depression status only in females, but not in males. HSV-2 infection appears to be primarily related to somatic symptoms rather than cognitive symptoms in the female population.

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成人HSV2感染与抑郁症的关联：2005-2016年NHANES的横断面研究

背景和目的抑郁症是一种主要的精神系统疾病，以往的研究发现单纯疱疹病毒 2（HSV-2）感染与抑郁症之间存在关联。方法我们获得了 2005-2016 年 NHANES 数据，共选取了 1124 例抑郁症病例和 4253 例匹配对照，匹配比例为 1:4。采用逻辑回归法探讨 HSV-2 感染与抑郁状态和严重程度的关系。结果HSV2感染与抑郁状态（OR=1.33, 1.11∼1.59）和严重程度（OR=1.24, 1.05∼1.45）呈正相关，但这些关联仅在女性中观察到，在男性中没有观察到。此外，零膨胀负二项回归结果表明，HSV2 感染会增加女性的躯体症状总分（RR=1.15, 1.16∼1.25），而不是认知症状。此外，HSV2 感染与睡眠困难、疲劳和食欲问题等躯体症状的增加有关，但与任何认知症状无关。在女性人群中，HSV-2 感染似乎主要与躯体症状而非认知症状有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.