European Journal of Psychiatry最新文献

{"title":"Safety and effectiveness of oral blonanserin for schizophrenia in adolescents in China: Data from a 12-week post-marketing surveillance","authors":"Yun Yu ,&nbsp;Xijin Wang ,&nbsp;Ruiling Zhang ,&nbsp;Keqing Li ,&nbsp;Gang Wang ,&nbsp;Jindong Chen ,&nbsp;Meijuan Sun ,&nbsp;Zhiyuan Xun ,&nbsp;Xiaodong Yang ,&nbsp;Guijun Zhao ,&nbsp;Haiyun Li ,&nbsp;Xuejun Liu","doi":"10.1016/j.ejpsy.2023.07.005","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.005","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Blonanserin is a second-generation </span>antipsychotic<span> (SGA)for the treatment of schizophrenia and has been approved for use in Japan, South Korea and China. This analysis aimed to evaluate the effectiveness and safety of blonanserin in Chinese adolescent patients, using data from a post-marketing surveillance of blonanserin started in September 2018.</span></p></div><div><h3>Methods</h3><p>A 12-week, prospective, multi-center, open-label post-marketing surveillance was conducted. Patients in this analysis were stratified by age.</p></div><div><h3>Results</h3><p>78 patients with schizophrenia aged &lt; 18 years were included. The incidence of adverse drug reactions<span> in adolescent patients was 33.3% significantly higher than patients over 40 years old. After 12-week treatment, 8.1% of adolescent patients had a weight gain ≥ 7%, and it was not significantly different from other age groups. Mean Brief Psychiatric Rating Scale (BPRS) total score was significantly reduced at week 12, and the decline of anergia score and thought disturbance score of adolescent patients was significantly greater than in adults.</span></p></div><div><h3>Conclusions</h3><p>Blonanserin was well tolerated and effective in the treatment of schizophrenia in Chinese adolescent patients in real-world clinical practice. Blonanserin might be a reasonable choice for the treatment of schizophrenia in adolescent patients.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100222"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based umbrella review of non-invasive brain stimulation in anxiety disorders","authors":"Katia Nunes Sá ,&nbsp;Rachel Fontes Baptista ,&nbsp;Livia Shirahige ,&nbsp;Laís B. Razza ,&nbsp;Mateus Nogueira ,&nbsp;Maria Helena Faria Coura ,&nbsp;Leonardo Afonso-Santos ,&nbsp;Clarice Tanaka ,&nbsp;Abrahão Fontes Baptista ,&nbsp;Katia Monte-Silva ,&nbsp;André R. Brunoni","doi":"10.1016/j.ejpsy.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.01.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Although several meta-analyses have suggested the efficacy of non-invasive brain stimulation (NIBS) mainly in prefrontal brain areas to treat </span>mental disorders<span>, no synthetic approach has been performed for other psychiatric disorders rather than depression. The objective is to assess the available evidence of NIBS in the treatment of anxiety disorders.</span></p></div><div><h3>Methods</h3><p>An umbrella review (CRD42021239577) was performed only looking for reviews with meta-analyses of randomized clinical trials using a source strategy MeSH keywords in MEDLINE through Pubmed by two independent researchers. The effects of different methods of NIBS in anxiety disorders were assessed using the PICO strategy. The methodological quality was evaluated using AMSTAR-2 and certainty of evidence using the GRADE-pro framework.</p></div><div><h3>Results</h3><p><span><span>From 136 screening meta-analyses, 16 from 14 studies were included in the final analysis. Generalized Anxiety Disorder (GAD) and </span>Obsessive Compulsive Disorder<span> (OCD) respond best to low frequency repetitive transcranial magnetic stimulation (rTMS), while </span></span>Posttraumatic Stress Disorder (PTSD) has the largest effect size at high frequency rTMS. Panic Disorder (PD) has no evidence for clinical use of NIBS. There were not identified meta-analyses about other anxiety disorders. In general, the included studies had good methodological quality, but low to moderate evidence for clinical recommendation.</p></div><div><h3>Conclusion</h3><p>Available evidence reveals NIBS as an effective and safe approach to treat GAD, PTSD and OCD with low recommendation level to clinical application. A great heterogeneity of studies indicates the necessity to develop new randomized clinical trials applying NIBS to treat those and other mental disorders.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 167-181"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosis in adults with autism spectrum disorder and attention deficit hyperactivity disorder at acute psychiatric wards","authors":"Hiromitsu Uno ,&nbsp;Wakaho Hayashi ,&nbsp;Akari Nakagawa ,&nbsp;Takeshi Otowa ,&nbsp;Hiroki Yamada ,&nbsp;Akira Iwanami","doi":"10.1016/j.ejpsy.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.12.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Psychotic symptoms, such as delusions and hallucinations, in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) have been increasingly reported in recent literature. In the present study, the prevalence and duration of psychotic symptoms, comorbid psychotic disorders, and clinical characteristics of adults with ASD and ADHD were retrospectively examined via a chart review.</p></div><div><h3>Methods</h3><p>The participants were 98 adults (mean age, 28.5 years; 72 men) who were admitted to the psychiatric emergency wards of Showa University Karasuyama Hospital, and who were diagnosed with ASD and/or ADHD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria.</p></div><div><h3>Results</h3><p>Among 69 individuals with ASD, 21 (30.4%) experienced psychotic symptoms, and among 29 individuals with ADHD, 5 (17.2%) exhibited psychosis. While all psychotic symptoms were classified as transient and none had comorbidity with schizophrenia and other psychotic disorders in adults with ADHD, 38.1% of psychosis was classified as prolonged and 10.3% had comorbidity with schizophrenia and other psychotic disorders in adults with ASD.</p></div><div><h3>Conclusion</h3><p>The results showed that a significant proportion of adults with ASD and ADHD experience psychosis during their course of illness, and provide evidence for the existence of a shared etiology between neurodevelopmental and psychotic disorders.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 182-189"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished prefrontal hemodynamic response in adult attention deficit hyperactivity disorder: a multi-channel functional near-infrared spectroscopy study","authors":"Y. Zhang,&nbsp;M. Ran,&nbsp;X. Zhang,&nbsp;M. Wang,&nbsp;M. Wang,&nbsp;G. Jiang","doi":"10.1016/j.ejpsy.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.02.001","url":null,"abstract":"<div><h3>Background and aims</h3><p>Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Adult ADHD is currently diagnosed based only on subjective clinical and scoring measures, which inevitably lead to a low correct diagnosis rate. Hence, an effective auxiliary examination with higher sensitivity is needed.</p></div><div><h3>Method</h3><p>Twenty healthy controls (HC) subjects and 20 adults with ADHD were included in this study. The functional near-infrared spectroscopy (fNIRS) under verbal fluency test (VFT) was performed to detect cerebral cortex hemodynamics. Correlation and Receiver operating characteristic (ROC) curve analysis were employed to reveal the relationship between differences in hemodynamic response and clinical characteristics.</p></div><div><h3>Results</h3><p>The HbO response of adult ADHD in the prefrontal cortex (PFC) was significantly smaller than that of HC. HbO concentration changes in the corresponding channels were negatively correlated with the ASRS-inattention score. HbO concentration changes of channels 16 and 26 corresponding to the medial PFC might be helpful for the diagnosis of adult ADHD.</p></div><div><h3>Conclusion</h3><p>Adult ADHD patients have low activation of the PFC, changes of whose corresponding channels were significantly associated with attention deficit, indicating that fNIRS under VFT may be an effective auxiliary examination for adult ADHD.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 160-166"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High molar ratios of tumor necrosis factor α (TNF α) soluble receptors I and II to the TNF ligand in human plasma from male veterans with comorbid posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI)","authors":"T.I. Morales ,&nbsp;C.E. Stamper ,&nbsp;L.A. Brenner","doi":"10.1016/j.ejpsy.2023.03.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.03.003","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>Posttraumatic stress disorder (PTSD) and traumatic brain injury (TBI) are associated with chronic inflammation, as inferred from increased, but variable, peripheral levels of cytokines. We sought proof of concept for the notion that peripheral cytokine binding proteins and/or soluble receptors can confound measures of cytokines in those with a history of physical and psychological traumatic exposures. Efforts were focused on one of the major cytokines involved in inflammation, tumor necrosis factor-α (TNF- α).</p></div><div><h3>Methods</h3><p>We examined blood plasma concentrations of TNF-α, its soluble receptors (TNF-soluble receptors (sR) I and TNFsRII), and C-reactive protein (CRP-1) in a cohort of US Veterans. In a previous study, CRP-1 was shown to be reduced by probiotic anti-inflammatory treatment in this patient cohort. All participants (<em>n</em> = 22) were diagnosed with PTSD and had a history of mild TBI with persistent post-concussive symptoms. Exclusion criteria included medications directly targeting inflammation.</p></div><div><h3>Results</h3><p>Molar concentrations of soluble TNFsRI and II exceeded concentrations of the TNF-α ligand. TNFsRI, but not TNFsRII, was significantly associated with CRP-1 (Spearman Rho correlations = 0.518; <em>p</em>=.016 and 0.365; <em>p</em> = .104, respectively).</p></div><div><h3>Conclusions</h3><p>TNF soluble receptors may bind to and sequester free TNF-α, suggesting that only measuring ligand concentrations may not provide a fully comprehensive view of inflammation, and potentially lead to inaccurate conclusions. TNFsRI concentration may provide a better estimate of inflammation than TNF-α for those with PTSD and post-acute mTBI with post-concussive symptoms, a hypothesis that invites further testing in larger studies.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 141-148"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"We need to talk science","authors":"Daniel Guinart MD, PhD ,&nbsp;Victor Perez-Solà MD, PhD","doi":"10.1016/j.ejpsy.2023.07.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.003","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 139-140"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suicide survivors. A population at risk","authors":"María Irigoyen-Otiñano ,&nbsp;Carla Albert-Porcar ,&nbsp;Cecilia Borrás ,&nbsp;Margarita Puigdevall-Ruestes ,&nbsp;Ana González-Pinto","doi":"10.1016/j.ejpsy.2022.11.001","DOIUrl":"10.1016/j.ejpsy.2022.11.001","url":null,"abstract":"","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 199-200"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9829518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9099354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linguistic markers of demoralization improvement in schizophrenia: A pilot study","authors":"F. Folesani ,&nbsp;Martino Belvederi Murri ,&nbsp;C. Puggioni ,&nbsp;E. Tiberto ,&nbsp;M. Marella ,&nbsp;T. Toffanin ,&nbsp;L. Zerbinati ,&nbsp;M.G. Nanni ,&nbsp;R. Caruso ,&nbsp;D. Brunato ,&nbsp;A.A. Ravelli ,&nbsp;F. Dell'Orletta ,&nbsp;H.M. Chochinov ,&nbsp;L. Grassi","doi":"10.1016/j.ejpsy.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.03.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Individuals with schizophrenia display language impairments involving pragmatics, semantics and syntax. Language impairments may show diagnostic specificity and could relate to the ability of engaging in psychotherapy. This pilot study sought to: (1) identify linguistic features that might differentiate individuals with schizophrenia from distressed controls without psychotic symptoms; and (2) examine the association between linguistic abilities and clinical changes during psychotherapy.</p></div><div><h3>Methods</h3><p>We recruited patients with schizophrenia and a comparison group of individuals with demoralization and distress due to cancer. Participants underwent Dignity Therapy (DT), an existentially-oriented brief psychotherapy focused on legacy and subjective dignity. Verbatim transcripts of the DT sessions were analysed using Natural Language Processing (NLP). In addition, we measured changes in levels of demoralization and dignity-related distress before and after DT, exploring the association with linguistic variables with network analysis.</p></div><div><h3>Results</h3><p>Patients with schizophrenia could be differentiated from those with cancer-related distress using only three out of 141 linguistic variables: total number of words, number of prepositional chains and conversational elements. Across groups, better levels of discourse coherence and higher number of arguments controlled by a predicate (verb “arity”) were associated with larger improvements in demoralization and, indirectly, dignity-related distress.</p></div><div><h3>Conclusions</h3><p>Reproducible linguistic markers may be able to differentiate individuals with schizophrenia from those with less severe psychopathology, and to predict better uptake of psychotherapy independent from diagnosis. Future studies should explore whether linguistic features derived from NLP may be exploited as accessible diagnostic or prognostic markers to tailor psychotherapy and other interventions in schizophrenia.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 149-159"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors promoting alliance quality: Differentiation of therapeutic alliance according to the formal aspects of the psychotherapeutic process and demographic variables","authors":"Tomasz Prusiński","doi":"10.1016/j.ejpsy.2022.11.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2022.11.002","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>The study's main aim was to determine which formal aspects of psychotherapy (therapist's work experience, number of sessions held, frequency of meetings, length of sessions) contributed to the quality of the therapeutic (working) alliance. The alliance was also analyzed for demographic variables.</p></div><div><h3>Methods</h3><p>The sample consisted of 428 participants, and the working alliance was evaluated in 262 psychotherapist–patient dyads. To assess its quality, the author used the full version of the Working Alliance Inventory (WAI).</p></div><div><h3>Results</h3><p>The analyzes led to several conclusions. Their results indicate that the quality of working alliance increases if psychotherapy is conducted by an experienced specialist, if the frequency of sessions is high, and if the sessions are longer. They do not, however, pinpoint the demographic markers of therapeutic alliance quality.</p></div><div><h3>Conclusion</h3><p>The formal aspects of the psychotherapeutic process influence the quality of the working alliance. Alliance develops to an equal degree in people of different ages and with diverse levels of education, regardless of the presence or absence of close interpersonal relationships in their lives.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 190-198"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical publishing: a flawed model in dire need of reform","authors":"N. Gupta ,&nbsp;S. Kapur","doi":"10.1016/j.ejpsy.2020.12.001","DOIUrl":"10.1016/j.ejpsy.2020.12.001","url":null,"abstract":"<div><p>Recently, in the midst of the Covid-19 pandemic, high-profile retractions of some papers published in prestigious medical journals have highlighted the necessity for structural reform to the current model of medical publishing. We discuss what ails the current system and what can be done to remedy it.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 2","pages":"Pages 136-138"},"PeriodicalIF":1.8,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ejpsy.2020.12.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9307213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}