European Journal of Psychiatry最新文献

{"title":"Claudin-5, occludin, zonulin and tricellulin levels of children with attention-deficit/hyperactivity disorder","authors":"Hurşit Ferahkaya ,&nbsp;Ömer Faruk Akça ,&nbsp;Tamer Baysal ,&nbsp;İbrahim Kılınç","doi":"10.1016/j.ejpsy.2023.100225","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100225","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Accumulating studies have pointed out that gut-blood and blood-brain barrier dysfunctions due to the alterations in permeability may play a role in the pathophysiology of neurodevelopmental disorders. Tight junctions are crucial components of these barriers and some peptides including claudin-5, </span>occludin<span>, zonulin and tricellulin are important components of these structures. This study aimed to investigate the relationship between these molecules and attention deficit hyperactivity disorder (ADHD) in children and adolescents.</span></p></div><div><h3>Methods</h3><p>A total of 57 children with ADHD and 60 controls aged between 6 and 12 years were included in the study. The severity of ADHD symptoms was assessed through a parent-rated questionnaire, and Conner's Continuous Performance Test<span> was administered to the study group. Serum levels of biochemical variables were measured using enzyme-linked immunosorbent assay kits. Biochemical parameter levels and scale scores were compared using Mann-Whitney U or Student's t tests<span>. In addition, a multivariate analysis of covariance (MANCOVA) and a one-way analysis of covariance (ANCOVA) was performed on the outcome variables. Finally, a hierarchical regression model was conducted on the study group.</span></span></p></div><div><h3>Results</h3><p>Serum claudin-5 and tricellulin levels were significantly lower in the ADHD group compared to the control group. The difference between the groups in terms of serum claudin-5 and tricellulin levels remained significant after controlling for confounding factors such as age, gender and autistic characteristics. There was no significant difference between the groups in terms of serum zonulin and occludin levels.</p></div><div><h3>Conclusion</h3><p>These results reveal that claudin-5 and tricellulin levels vary in patients with ADHD. Alterations in these peptides may affect the brain by leading to a dysregulation in intestinal or blood-brain barrier permeability. The causal relationship between these peptides and ADHD requires further investigation.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"38 1","pages":"Article 100225"},"PeriodicalIF":1.8,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor analysis and validation of the Bush Francis catatonia rating scale-Spain version","authors":"Jorge Cuevas-Esteban ,&nbsp;Francesc Serrat ,&nbsp;Luisa Baladon ,&nbsp;Neus Rabaneda-Lombarte ,&nbsp;Crisanto Díez-Quevedo ,&nbsp;Maria Iglesias-González","doi":"10.1016/j.ejpsy.2023.07.004","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.004","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The aim of this study was to assess the reliability and validity of the Bush Francis Catatonia Screening Instrument and Bush Francis Catatonia Rating Scale Spain Version (BFCSI-SV and BFCRS-SV) using the ICD-11 and DSM-5 diagnostic criteria as well as other catatonia scales.</p></div><div><h3>Methods</h3><p><span>One hundred patients were admitted to the inpatient psychiatry unit at Hospital Universitari Germans Trias I Pujol and two psychiatrists administered the BFCRS-SV to the first 10 patients to assess inter-rater reliability. The BFCRS-SV, BFCSI-SV, Modified Rogers Scale (MRS), </span>Abnormal Involuntary Movement Scales<span>, Barnes Akathisia Rating Scale, and Modified Simpson-Angus Scale were then employed.</span></p></div><div><h3>Results</h3><p>The results showed that 27% of patients had catatonia using the DSM-5 diagnostic criteria. Additionally, 51% of patients had 2 or more BFCRSI-SV items (Sensitivity: 100%; Specificity: 67.12%). The alpha coefficient values were 0.80 and 0.84 for the BFCSI-SV and BFCRS-SV, respectively, and the intraclass correlation coefficient values were 0.902 and 0.903. The area under the ROC curve was 0.971 and 0.96, and the instruments had a strong positive correlation with the DSM-5 score, ICD-11 score, and MRS. The study identified a three-factor model comprising the inhibition, excitement, and parakinetic dimensions.</p></div><div><h3>Conclusions</h3><p>Overall, the results suggest that the BFCSI-SV and BFCRS-SV are valid and reliable tools for the diagnosis of catatonia, especially when using a cut-off score of 5 or higher for the BFCSI-SV and 7 or higher for the BFCRS-SV.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100221"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anxiety symptoms and disorders during the COVID-19 pandemic in children and adolescents: Systematic review and meta-analysis","authors":"Urvashi Panchal ,&nbsp;Julio David Vaquerizo-Serrano ,&nbsp;Ileana Conde-Ghigliazza ,&nbsp;Herdem Aslan Genç ,&nbsp;Simone Marchini ,&nbsp;Kamile Pociute ,&nbsp;Binay Kayan Ocakoğlu ,&nbsp;Szarah Sanchez-Roman ,&nbsp;Dorottya Ori ,&nbsp;Ana Catalan ,&nbsp;Luis Alameda ,&nbsp;Samuele Cortese ,&nbsp;Gonzalo Salazar de Pablo","doi":"10.1016/j.ejpsy.2023.06.003","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.06.003","url":null,"abstract":"<div><h3>Background and Objectives</h3><p>The COVID-19 pandemic and its associated factors have been shown to affect anxiety levels of young people. We meta-analytically assessed the prevalence of anxiety symptoms and anxiety disorders in children and adolescents during the pandemic, and the predictors and moderating factors influencing anxiety.</p></div><div><h3>Methods</h3><p>Multiple databases and registers were searched in this PRISMA and MOOSE-compliant systematic review and meta-analysis (PROSPERO:CRD42021266695) until 27/06/2021. We included individual studies evaluating the prevalence and characteristics of anxiety symptoms or anxiety disorders in children and adolescents (mean age ≤18 years), during the COVID-19 pandemic. Data extraction and quality assessment were carried out by independent authors. Random-effects meta-analyses of the prevalence of anxiety symptoms and anxiety disorders were conducted using Comprehensive Meta-Analysis (CMA) V3.</p></div><div><h3>Results</h3><p>74 articles (total participant sample=478,882) were included (mean age=13.4 years, 52.3% female). The pooled rate of children and adolescents fulfilling diagnostic criteria for anxiety disorders was 13.0% (95%CI=4.9–30.1); the pooled prevalence of anxiety symptoms was 26.5% (95%CI=20.3–33.9). Anxiety symptoms were significantly more prevalent in females than males (<em>B</em> = 0.103, <em>p</em>&lt;.001), significantly higher during the second wave of COVID-19, following July 2020, than during the first wave, prior to June 2020, (<em>Q</em>= 8.136, <em>p</em>=.017), and during school closure (<em>Q</em>= 8.100, <em>p</em>=.014). Quality of included studies was overall moderate.</p></div><div><h3>Conclusions</h3><p>There is a high prevalence of anxiety symptoms in children and adolescents during the COVID-19 pandemic, especially amongst females. This study identifies vulnerable groups, risk, and protective factors, which is crucial to developing clinical practice to prevent further mental health deterioration in young people.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100218"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of developing avascular necrosis of the femoral head and neck among patients with bipolar disorder: A nationwide cohort study","authors":"Dian-Jeng Li ,&nbsp;Ta-Chuan Yeh ,&nbsp;Shih-Jen Tsai ,&nbsp;Tzeng-Ji Chen ,&nbsp;Chih-Sung Liang ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.ejpsy.2023.100224","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100224","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>The association between bipolar disorder (BD) and </span>avascular necrosis<span> of the femoral head and neck (AVNHNF) remains unclear. We aimed to investigate the risk of AVNHNF among different polarity of BD.</span></p></div><div><h3>Methods</h3><p>Between 2001 and 2010, patients with BD were selected from the Taiwan National Health Research Database. The controls were individuals without severe mental disorder who were matched for demographic, medical and psychiatric comorbidities. Cox regression analysis was used to estimate the risk of AVNHNF, with adjustments for demographics, comorbidities, exposure to corticosteroids, and all-cause clinical visits.</p></div><div><h3>Results</h3><p>A total of 84,721 patients with BD and 169,442 controls were included. Patients with BD demonstrated a 1.92-fold (95% of confidence interval: 1.21–3.04) higher risk of AVNHNF compared with the controls. The risk was increased to 7.91-fold (4.32–14.49) in patients<span><span> with severe BD compared with the controls. Importantly, patients with severe bipolar depression were associated with a 14.23-fold higher risk of AVNHNF compared with the controls, while those with sever </span>bipolar mania were associated with a 3.55-fold higher risk. Compared with the controls with alcohol use disorder (AUD), patients with BD and comorbid AUD were associated with a 2.0-fold higher risk of AVNHNF. Finally, long-term use of atypical antipsychotics was associated with a decreased risk of AVNHNF).</span></p></div><div><h3>Conclusion</h3><p>Clinicians should be aware of the increased risk of AVNHNF among patients with BD. This increased risk was associated with disorder severity, polarity, and comorbidity with AUD, and attenuated by long-term atypical antipsychotic treatment.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100224"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Borderline personality disorder vs. mood disorders: clinical comparisons in young people treated within an “Early Intervention” service for first episode psychosis","authors":"Lorenzo Pelizza ,&nbsp;Emanuela Leuci ,&nbsp;Emanuela Quattrone ,&nbsp;Silvia Azzali ,&nbsp;Giuseppina Paulillo ,&nbsp;Simona Pupo ,&nbsp;Pietro Pellegrini ,&nbsp;Arianna Biancalani ,&nbsp;Lorenzo Gammino ,&nbsp;Marco Menchetti","doi":"10.1016/j.ejpsy.2023.07.002","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.002","url":null,"abstract":"<div><h3>Background and Objective</h3><p>Borderline Personality Disorder (BPD) is under-investigated in First Episode Psychosis (FEP). BPD psychotic manifestations and mood changes are also difficult to differentiate from first episode affective psychosis. The aim of this study was to compare sociodemographic and clinical features between FEP patients with BPD vs. Bipolar Disorder<span> (BD) or Major Depressive Disorder (MDD) both at baseline and across a 2-year follow-up period.</span></p></div><div><h3>Methods</h3><p><span>224 FEP participants (49 with BPD, 93 with BD and 82 with MDD) completed the Health of the Nation Outcome Scale (HoNOS), the Positive And Negative Syndrome Scale (PANSS) and the </span>Global Assessment of Functioning<span> (GAF) scale. Psychiatric diagnosis was reformulated at the end of our follow-up. Inter-group comparisons were analyzed using the Kruskal-Wallis or the Chi-square test. A mixed-design ANOVA model was also performed to assess the temporal stability of clinical scores within and between the 3 subgroups.</span></p></div><div><h3>Results</h3><p>Compared to FEP/BD subjects at baseline, FEP/BPD patients showed higher depressive symptom severity and lower excitement severity. Compared to FEP/MDD at entry, they had a higher prevalence rate of substance abuse, a lower interpersonal impairment and a shorter DUP. Finally, they had a lower treatment response on HoNOS “Psychiatric Symptoms” subscale scores across the follow-up in comparison with both FEP/BD and FEP/MDD individuals.</p></div><div><h3>Conclusion</h3><p>BPD as categorical entity represents a FEP subgroup with specific clinical features and treatment response. Appropriate treatment guidelines for this FEP subgroup are thus needed.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100219"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotic-like experiences in obsessive compulsive disorder","authors":"Ulaş Korkmaz ,&nbsp;Ahmet Rifat Şahin ,&nbsp;Ömer Böke ,&nbsp;Gökhan Sarısoy ,&nbsp;Aytül Karabekiroğlu ,&nbsp;Selçuk Özdin ,&nbsp;Hatice Özyıldız Güz","doi":"10.1016/j.ejpsy.2023.06.001","DOIUrl":"10.1016/j.ejpsy.2023.06.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>The study aims to compare individuals diagnosed with obsessive-compulsive disorder (OCD) and healthy individuals in terms of psychosis-like experiences (PLEs) and investigate the relationship between PLEs and OCD severity.</p></div><div><h3>Methods</h3><p>Sociodemographic information form, Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the positive dimension of Community Assessment of Psychic Experiences (CAPE-P), Hamilton Depression Rating Scale<span> (HAM-D), and Hamilton Anxiety Rating Scale (HAM-A) were applied to 83 OCD patients and 83 healthy individuals. The 11th item of Y-BOCS (Y-BOCS-11) was used to evaluate the level of insight. The OCD group was compared with the healthy control group in terms of sociodemographic information and CAPE-P score. In the OCD group, mediation analyses were performed to evaluate the factors affecting the relationship between OCD severity and PLEs.</span></p></div><div><h3>Results</h3><p>The OCD group had higher CAPE-P scores than the healthy control group. CAPE-P scores were weakly correlated with Y-BOCS-11 and Y-BOCS total scores. It was found that the relationship between OCD severity and PLEs was mediated by poor insight; however, the scores of depression and anxiety did not.</p></div><div><h3>Conclusion</h3><p>The results show that the level of insight is a determinative factor for PLEs in OCD. The fact that PLEs are common in the OCD group and healthy individuals support the concept of the psychosis continuum. We emphasize that being aware of PLEs in OCD can provide new understandings of the phenomenon of OCD and psychosis.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100215"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75180039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between mental health problems and asthma among European school children","authors":"James Goldin ,&nbsp;Florence Bodeau-Livinec ,&nbsp;Dietmar Goelitz ,&nbsp;Adina Bitfoi ,&nbsp;Mauro Giovanni Carta ,&nbsp;Ceren Koç ,&nbsp;Sigita Lesinskiene ,&nbsp;Zlatka Mihova ,&nbsp;Roy Otten ,&nbsp;Viviane Kovess-Masfety","doi":"10.1016/j.ejpsy.2023.100223","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.100223","url":null,"abstract":"<div><h3>Background and objectives</h3><p>To examine the prevalence of two ISAAC (International Study of Asthma and Allergies in Childhood) asthma indicators in 7 European countries and their relationship with mental health disorders in children 6–12 years.</p></div><div><h3>Methods</h3><p>A cross-sectional survey of 5712 school children aged<span> 6–12 years using a video Self-administered instrument: Dominic Interactive and the Strengths and Difficulties Questionnaire (SDQ) for parents and teachers. Asthma indicators were 12 month “Wheezing or whistling in the chest” (WWC) and “Severe Asthma” (SA) based on number of attacks of wheezing, sleep disturbance due to wheezing, and limits to speech.</span></p></div><div><h3>Results</h3><p>On average 7.31% of the children had WWC, from 15.09% in Turkey to 1.32% in Italy; SA 2.22% on average ranged from 4.78% in Turkey to 0% in Italy. Generalized Anxiety Disorder (GAD) from child self-reports was significantly associated with WWC and SA even after adjustment for covariates. Based on parent and teacher combined reports, emotional problems were found to have significant associations with 12-month WWC after adjustment, as well as “any problems” which summarized externalizing and internalizing disorders Emotional, hyperactivity, conduct disorders were not associated with SA.</p></div><div><h3>Conclusion</h3><p>Asthma indicators very much differ across countries. Asthma indicators are associated with childhood GAD. Childhood self-reported mental health seems more related to Asthma indicators than parents/teachers combined reports.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100223"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of anxiety symptoms in first-episode and drug-naïve major depressive disorder patients with metabolic syndrome","authors":"Jizhou Liu ,&nbsp;Yonglan Yang ,&nbsp;Yanjiang Zhang ,&nbsp;Haifeng Wang ,&nbsp;Wenjian Wei ,&nbsp;Xiaoe Lang ,&nbsp;Xiangyang Zhang","doi":"10.1016/j.ejpsy.2023.07.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p>Patients with major depressive disorder (MDD) have high comorbidity with metabolic syndrome (MetS), although anxiety is prevalent comorbidity in MDD patients. However, there is no study on anxiety symptoms (AS) in MDD patients with MetS. Therefore, we aimed to identify the prevalence and risk factors of AS in patients with MetS who experienced a first-episode and drug naïve (FEDN) of MDD.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, 1718 FEDN of MDD outpatients with MetS were included. Sociodemographic data, clinical characteristics, suicidal attempts, and physical and biochemical parameters were collected. Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Positive and Negative Syndrome Scale (PANSS) positive subscale were performed to detect the AS. Multiple linear regression analysis was used to analyze the correlation.</p></div><div><h3>Results</h3><p>The prevalence of AS in MDD patients with MetS was 85.96%, which was 1.79 times greater than that in patients with MDD alone (<em>P</em>&lt;0.05). MDD patients with MetS had a greater rate of attempted suicide, a higher HAMD total score, and a higher diastolic blood pressure than MDD patients without AS (<em>P</em>&lt;0.05). Their combination could distinguish AS in MDD patients. Moreover, HAMD score, thyroid-stimulating hormone (TSH) levels, PANSS positive score, and suicide attempts were related to HAMA scores in MDD patients with comorbid MetS (<em>P</em>&lt;0.05).</p></div><div><h3>Conclusion</h3><p>There is a significant frequency of AS in MDD patients with MetS. Multiple clinical indicators and metabolic markers are associated with AS in patients with MDD and MetS.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100217"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50202021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of oral blonanserin for schizophrenia in adolescents in China: Data from a 12-week post-marketing surveillance","authors":"Yun Yu ,&nbsp;Xijin Wang ,&nbsp;Ruiling Zhang ,&nbsp;Keqing Li ,&nbsp;Gang Wang ,&nbsp;Jindong Chen ,&nbsp;Meijuan Sun ,&nbsp;Zhiyuan Xun ,&nbsp;Xiaodong Yang ,&nbsp;Guijun Zhao ,&nbsp;Haiyun Li ,&nbsp;Xuejun Liu","doi":"10.1016/j.ejpsy.2023.07.005","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.07.005","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Blonanserin is a second-generation </span>antipsychotic<span> (SGA)for the treatment of schizophrenia and has been approved for use in Japan, South Korea and China. This analysis aimed to evaluate the effectiveness and safety of blonanserin in Chinese adolescent patients, using data from a post-marketing surveillance of blonanserin started in September 2018.</span></p></div><div><h3>Methods</h3><p>A 12-week, prospective, multi-center, open-label post-marketing surveillance was conducted. Patients in this analysis were stratified by age.</p></div><div><h3>Results</h3><p>78 patients with schizophrenia aged &lt; 18 years were included. The incidence of adverse drug reactions<span> in adolescent patients was 33.3% significantly higher than patients over 40 years old. After 12-week treatment, 8.1% of adolescent patients had a weight gain ≥ 7%, and it was not significantly different from other age groups. Mean Brief Psychiatric Rating Scale (BPRS) total score was significantly reduced at week 12, and the decline of anergia score and thought disturbance score of adolescent patients was significantly greater than in adults.</span></p></div><div><h3>Conclusions</h3><p>Blonanserin was well tolerated and effective in the treatment of schizophrenia in Chinese adolescent patients in real-world clinical practice. Blonanserin might be a reasonable choice for the treatment of schizophrenia in adolescent patients.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 4","pages":"Article 100222"},"PeriodicalIF":1.8,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50201808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based umbrella review of non-invasive brain stimulation in anxiety disorders","authors":"Katia Nunes Sá ,&nbsp;Rachel Fontes Baptista ,&nbsp;Livia Shirahige ,&nbsp;Laís B. Razza ,&nbsp;Mateus Nogueira ,&nbsp;Maria Helena Faria Coura ,&nbsp;Leonardo Afonso-Santos ,&nbsp;Clarice Tanaka ,&nbsp;Abrahão Fontes Baptista ,&nbsp;Katia Monte-Silva ,&nbsp;André R. Brunoni","doi":"10.1016/j.ejpsy.2023.01.001","DOIUrl":"https://doi.org/10.1016/j.ejpsy.2023.01.001","url":null,"abstract":"<div><h3>Background and objectives</h3><p><span>Although several meta-analyses have suggested the efficacy of non-invasive brain stimulation (NIBS) mainly in prefrontal brain areas to treat </span>mental disorders<span>, no synthetic approach has been performed for other psychiatric disorders rather than depression. The objective is to assess the available evidence of NIBS in the treatment of anxiety disorders.</span></p></div><div><h3>Methods</h3><p>An umbrella review (CRD42021239577) was performed only looking for reviews with meta-analyses of randomized clinical trials using a source strategy MeSH keywords in MEDLINE through Pubmed by two independent researchers. The effects of different methods of NIBS in anxiety disorders were assessed using the PICO strategy. The methodological quality was evaluated using AMSTAR-2 and certainty of evidence using the GRADE-pro framework.</p></div><div><h3>Results</h3><p><span><span>From 136 screening meta-analyses, 16 from 14 studies were included in the final analysis. Generalized Anxiety Disorder (GAD) and </span>Obsessive Compulsive Disorder<span> (OCD) respond best to low frequency repetitive transcranial magnetic stimulation (rTMS), while </span></span>Posttraumatic Stress Disorder (PTSD) has the largest effect size at high frequency rTMS. Panic Disorder (PD) has no evidence for clinical use of NIBS. There were not identified meta-analyses about other anxiety disorders. In general, the included studies had good methodological quality, but low to moderate evidence for clinical recommendation.</p></div><div><h3>Conclusion</h3><p>Available evidence reveals NIBS as an effective and safe approach to treat GAD, PTSD and OCD with low recommendation level to clinical application. A great heterogeneity of studies indicates the necessity to develop new randomized clinical trials applying NIBS to treat those and other mental disorders.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"37 3","pages":"Pages 167-181"},"PeriodicalIF":1.8,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}