European Journal of Psychiatry最新文献

{"title":"Association of HSV2 infection and depression in adults: a cross-sectional study of NHANES from 2005–2016","authors":"Mingbo Wei ,&nbsp;Yi Feng ,&nbsp;Hongyan Peng ,&nbsp;Binbin Chen ,&nbsp;Yifan Wu ,&nbsp;Weiming Mao ,&nbsp;Qing Cai ,&nbsp;Jiajin Xu ,&nbsp;Laibao Yang ,&nbsp;Panpan Chen ,&nbsp;Huimin Zheng ,&nbsp;Licheng Yu","doi":"10.1016/j.ejpsy.2025.100312","DOIUrl":"10.1016/j.ejpsy.2025.100312","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Depression is a major mental system disorder, and previous studies have found an association between herpes simplex virus 2 (HSV-2) infection and depression. However, recently researches report that depression can be divided into two categories, cognitive symptoms and somatic symptoms, but the relationship between the subtypes of depression is still unknown.</div></div><div><h3>Methods</h3><div>We obtained NHANES data from cycles 2005–2016, and a total of 1124 depressed cases and 4253 matched controls were selected achieving a 1:4 matching ratio. Logistic regression was used to explore the association of HSV-2 infection with depression status and severity. Zero-inflated negative binomial regression was employed to assess associations between HSV-2 infection and specific cognitive/somatic symptoms of depression.</div></div><div><h3>Results</h3><div>HSV2 infection was positively associated with depression status (OR=1.33, 1.11∼1.59) and severity (OR=1.24, 1.05∼1.45), but these associations were only observed in female, not in male. Furtherly, result of Zero-inflated negative binomial regression suggested that HSV2 infection increased total score of somatic symptoms (RR=1.15, 1.16∼1.25) rather than cognitive symptoms in female. Moreover, HSV2 infection was related to increasing somatic symptoms, including sleeping difficulties, fatigue and appetite problems, but not any cognitive symptoms.</div></div><div><h3>Conclusion</h3><div>HSV-2 infection is positively associated with depression status only in females, but not in males. HSV-2 infection appears to be primarily related to somatic symptoms rather than cognitive symptoms in the female population.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100312"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of a two-dimensional trauma-neglect model: Two-year course of the Dutch Friesland study cohort","authors":"Sanne Swart ,&nbsp;Marleen Wildschut ,&nbsp;Willemien Langeland ,&nbsp;Adriaan W. Hoogendoorn ,&nbsp;Nel Draijer","doi":"10.1016/j.ejpsy.2025.100291","DOIUrl":"10.1016/j.ejpsy.2025.100291","url":null,"abstract":"<div><h3>Background and objectives</h3><div>This study tested the prognostic value of a two-dimensional trauma-neglect model by determining clinically relevant change in symptomatology of patients with (comorbid) trauma-related disorders, dissociative disorders and personality disorders after 2-year follow-up</div></div><div><h3>Methods</h3><div>Our cohort consisted of 150 patients who were referred to specialized treatment programs for trauma-related disorders, dissociative disorders or personality disorders. We determined clinically relevant change using the Relevant Change Index and used logistic regression analysis to test the prognostic value of the trauma-neglect model.</div></div><div><h3>Results</h3><div>Our results showed that severity of a trauma-related diagnosis predicted clinically relevant change in dissociative symptoms, but not in other symptomatology. The number of personality disorders did not predict clinically relevant change in symptomatology.</div></div><div><h3>Conclusions</h3><div>We found little support for the prognostic value of the trauma-neglect model, and, contrary to our expectation, the severity of symptoms did not predict course in a negative way.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100291"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143136444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment-resistant depression and intranasal esketamine: Spanish clinical consensus on practical aspects","authors":"J. Antoni Ramos-Quiroga ,&nbsp;Fernando Mora ,&nbsp;Silvia Arostegui ,&nbsp;Narcís Cardoner ,&nbsp;Jon-Inaki Etxeandia-Pradera ,&nbsp;Rocío Gómez-Juanes ,&nbsp;Marcos Gómez-Revuelta ,&nbsp;José Manuel Montes ,&nbsp;Eduard Vieta","doi":"10.1016/j.ejpsy.2025.100313","DOIUrl":"10.1016/j.ejpsy.2025.100313","url":null,"abstract":"<div><h3>Background</h3><div>Pharmacological management of major depressive disorder has traditionally relied on antidepressants targeting the monoaminergic pathway. Treatment-resistant depression (TRD) patients have been frequently excluded from registrational trials, resulting in a lack of clear clinical recommendations for an optimised management. In recent years, treatments based on other mechanisms of action have been developed and approved. Intranasal esketamine is a novel non-monoaminergic treatment directed to improve neuroplasticity through the modulation of the glutamatergic system. In this clinical consensus we aimed to provide expert guidance on the use of intranasal esketamine for TRD patients based in our clinical practice in Spain.</div></div><div><h3>Methods</h3><div>A scientific committee of nine psychiatrists, experts in TRD in Spain, reviewed the literature (grey literature and articles/scientific communications published in English or Spanish between January 2014 and January 2024 in PubMed). Statements on practical aspects of TRD management with intranasal esketamine were developed in a first meeting following a discussion group approach, refined in a second meeting with a nominal group technique, and finally drafted after consensus in a third meeting.</div></div><div><h3>Results</h3><div>We recommend a treatment algorithm for the management of TRD with intranasal esketamine. Recommendations were made for specific clinical profiles with other psychiatric comorbidities, which are not contraindications, and for patients who do not have at least a 50 % reduction in symptoms during the first induction phase (partial responders at the end of an induction phase). Treatment should be given in the same health centre where the patient normally receives mental care. The patient’s clinical progress will determine early optimisation of intranasal esketamine dose during the induction phase, the need for flexible doses/repeating the induction treatment phase, customisation of management, and treatment duration. We described factors impacting the use of intranasal esketamine and made recommendations on the characteristics of the ideal setting for its administration. Socio-economic aspects of intranasal esketamine were reviewed.</div></div><div><h3>Conclusions</h3><div>This is the first consensus developed in Spain regarding practical aspects of TRD management with intranasal esketamine, with a treatment algorithm for patients who are only partial responders at the end of the induction phase.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100313"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in emergency health care due to suicidal behaviour in youth and adult populations","authors":"Sofía Abascal-Peiró ,&nbsp;Alejandro Porras-Segovia ,&nbsp;Blanca Margarit-Parrondo ,&nbsp;Enrique Baca-García","doi":"10.1016/j.ejpsy.2025.100296","DOIUrl":"10.1016/j.ejpsy.2025.100296","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Since the outbreak of the COVID-19 pandemic, there has been a significant increase in mental health-related ED visits, especially in child and adolescent population. This study aims to analyze trends in emergency care for mental health, including suicidal behaviour, in adolescents over seven years, and compare them with adults.</div></div><div><h3>Methods</h3><div>This observational and retrospective study included 33,376 visits, involving 12,159 individuals, to the ED for mental health issues between 2015 and 2021 from two hospitals in Madrid (Hospital Fundación Jiménez Díaz and Hospital Rey Juan Carlos). Sociodemographic and clinical data were collected from electronic health records. Logistic regression models were used to identify factors associated with presentations for suicidal behavior, with odds ratios (OR) and 95 % confidence intervals (95 %CI).</div></div><div><h3>Results</h3><div>In adults, presenting to the emergency department for suicidal behaviour was significantly associated with family history of suicide (OR=1.497, 95 %CI [1.250–1.794]), higher number of previous suicide attempts (OR=1.376, 95 %CI [1.331–1.422]), and substance intoxication (OR=1.317, 95 %CI [1.132–1.533. In children and adolescents, previous suicide attempts (OR=1.803, 95 %CI [1.485–2.189]), being female (OR=1.848, 95 %CI [1.281–2.666]) and older age (OR=1.113, 95 %CI [1.015–1.222]) were associated with higher odds of presenting for suicidal behaviour. Neurodevelopmental disorders were also significantly associated with increased odds of presenting for suicidal behaviour (OR=5.328, 95 %CI [2.353–12.063]), while psychotic disorders (OR=0.133, 95 %CI [0.032–0.548]) and anxiety disorders (OR=0.282, 95 %CI [0.128–0.622]) were linked to lower odds. In contrast to adults, the percentage of ED visits for suicidal behaviour in children and adolescents increased steadily over the study period, peaking at 30.3 % in 2020</div></div><div><h3>Conclusion</h3><div>These findings underscore the need for age- and gender-specific approaches in the management and prevention of suicidal crises in mental health emergency settings, with special attention to past suicidal behavior and family history as critical risk factors.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100296"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperprolactinemia in drug-naïve first episode psychosis and its association with BDNF levels","authors":"A Toll ,&nbsp;D Bergé ,&nbsp;L Martínez-Sadurní ,&nbsp;A Trabsa ,&nbsp;V Perez-Sola ,&nbsp;A Mané","doi":"10.1016/j.ejpsy.2025.100307","DOIUrl":"10.1016/j.ejpsy.2025.100307","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Hyperprolactinemia is a common and well-known side effect of antipsychotic treatment. However, prolactin levels are elevated in drug-naïve first-episode psychosis (FEP) patients, which suggests that the association between prolactin and psychosis may be more complex than previously thought. One possible hypothesis to explain this association is that prolactin has a neuroprotective effect mediated by BDNF.</div></div><div><h3>Methods</h3><div>50 drug- naïve FEP were included and clinical characteristics as DUP; tobacco and cannabis use; and BMI were assessed. The PANSS and GAF questionnaires were administered. Fasting blood samples were obtained to determine prolactin, TSH, and BDNF levels. All statistical analyses were performed in the whole sample and stratified by sex.</div></div><div><h3>Results</h3><div>Of the 50 patients, 42 % had hyperprolactinemia (33.3 % of males and 55 % of females). Prolactin levels were negatively correlated with baseline GAF scores in the whole sample and in females but not in males. Prolactin levels were positively and independently associated (regardless of sex, age, BMI, TSH level, tobacco or cannabis use) with BDNF levels.</div></div><div><h3>Conclusions</h3><div>Prolactin secretion may be dysregulated in drug-naïve FEP, which implies that hyperprolactinemia—a common condition in FEP —may not be solely attributable to antipsychotic treatment. Elevated prolactin levels could reflect a physiological response designed to protect the central nervous system in certain critical situations. This neuroprotective effect could be mediated by increasing BDNF levels. Hyperprolactinemia is common in antipsychotic-naïve FEP. This study shows that higher prolactin levels are associated with elevated BDNF levels, suggesting a neuroprotective effect mediated through BDNF in this patient population.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100307"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143800461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between psychological pain and suicidal behaviour in a cohort of patients at high risk of suicide","authors":"Ana Pérez-Balaguer ,&nbsp;Inmaculada Peñuelas-Calvo ,&nbsp;Ana María de Granda-Beltrán ,&nbsp;Jimena María Merayo-Cano ,&nbsp;Berta Ezquerra ,&nbsp;Adrián Alacreu-Crespo ,&nbsp;Enrique Baca-García ,&nbsp;Alejandro Porras-Segovia","doi":"10.1016/j.ejpsy.2025.100299","DOIUrl":"10.1016/j.ejpsy.2025.100299","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Suicide is a major global public health issue. Pain, both psychological and physical, are potential risks factors for suicidal behaviour (SB). This study aims to explore the relationship between psychological and physical pain and SB in individuals at high risk of suicide.</div></div><div><h3>Methods</h3><div>This prospective cohort study included 322 participants recruited from emergency departments, psychiatric inpatient units, and outpatient mental health services in two hospitals in Madrid (Spain). Participants completed assessments at baseline and six months. Psychological and physical pain were measured using validated Visual Analog Scales (VAS). The primary outcome was the occurrence of suicidal events, documented through medical records and follow-up interviews. Kaplan-Meier survival analyses estimated the occurrence of suicidal events after 6 months of follow-up. Factors associated with suicidal events were analysed using univariate and multivariate Cox regression models to identify independent predictors of SB.</div></div><div><h3>Results</h3><div>Severe psychological pain in the previous 15 days was significantly associated with an increased risk of SB (<em>p</em> = 0.017), independently of depression severity. Younger age also emerged as a significant risk factor. No association was found between physical pain and SB.</div></div><div><h3>Conclusions</h3><div>Psychological pain is a key predictor of SB and should be a focus in suicide risk assessments. Further research is needed to improve measurement tools and develop targeted interventions in order to treat psychological pain effectively.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100299"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't feel comfortable in your own skin? The relationship between body dissatisfaction and social media use – A meta-analytical approach","authors":"Thomas Vlasak ,&nbsp;Alfred Barth ,&nbsp;Christoph Augner","doi":"10.1016/j.ejpsy.2025.100297","DOIUrl":"10.1016/j.ejpsy.2025.100297","url":null,"abstract":"<div><h3>Objective</h3><div>This meta-analysis aims to clarify the relationship between body dissatisfaction (BD) and social media use.</div></div><div><h3>Methods</h3><div>We searched for relevant original studies via multiple data bases (i.e. Web of Science, Scopus, PubMed, etc.) until October 2023. Based on the included studies, we carried out a meta-analysis examining moderating effects and subgroup differences while testing the robustness of the relationship between BD and social media use against publication bias and influential cases.</div></div><div><h3>Results</h3><div>We included 18 studies with a total sample size of <em>n</em> = 24 384 participants with a mean age of 19.94 years (SD= 9.86) published from 2013 to 2022. Higher levels of social media use were significantly correlated with higher BD (<em>r</em> = 0.14 (95 % CI from 0.09 to 0.18, <em>p &lt;</em> .001). The positive association between social media use and BD is robust against outlier exclusion and considering heterogeneity (<em>r</em> = 0.13 (95 % prediction interval from 0.04 to 0.23, <em>p &lt;</em> .001).</div></div><div><h3>Conclusion</h3><div>Our results show that higher levels of social media use are significantly associated with higher BD. Key mechanisms behind the relationship are discussed.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100297"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in 4466 mood disorder patients","authors":"Alessandro Miola ,&nbsp;Leonardo Tondo ,&nbsp;Ross J. Baldessarini","doi":"10.1016/j.ejpsy.2025.100303","DOIUrl":"10.1016/j.ejpsy.2025.100303","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Characteristics of women and men with bipolar disorder (BD) or major depressive disorder (MDD) have been described with inconsistent findings requiring additional assessment.</div></div><div><h3>Methods</h3><div>We evaluated clinical characteristics in 4466 consecutive, extensively evaluated mood disorder patients (1491 BD, 2975 MDD; 2795 women, 1671 men) using standard bivariate statistics and multivariable logistic regression modeling.</div></div><div><h3>Results</h3><div>Diagnosis of MDD occurred 2.28- (women) to 1.62- (men) times more than BD, but prevalence of type II BD (BD2) and type I (BD1) did not differ by gender. BD women had more familial mood disorders, early sexual abuse, anxious or cyclothymic temperament, depressive first episodes, depression–[hypo]mania–interval (DMI) and rapid-cycling course, as well as greater %-time depressed in prospective follow-up, with more suicide attempts but fewer suicides than BD men. BD women also showed more co-occurring anxiety disorder, eating disorder and medical comorbidity, including metabolic disorders and cancer, but lower rates of ADHD and substance-abuse than BD men. MDD women experienced more religious activity, sexual abuse, anxious or cyclothymic temperament, co-occurring eating disorder and medical comorbidity as well as less substance-abuse and ADHD than MDD men but did not differ from men in measures of prospective morbidity.</div></div><div><h3>Conclusions</h3><div>Many characteristics were selectively associated with women with mood disorders, but prospective morbidity was similar by gender except for greater %-time depressed among BD women. Limited ethnic diversity and treatment in specialized centers may affect generalizability of these findings to other settings.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100303"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychological interventions to improve cognitive biases in people with schizophrenia: A systematic review","authors":"Marcel Gratacós-Torras ,&nbsp;Esther Pousa ,&nbsp;Susana Ochoa ,&nbsp;Josep Manel Santos","doi":"10.1016/j.ejpsy.2025.100304","DOIUrl":"10.1016/j.ejpsy.2025.100304","url":null,"abstract":"<div><h3>Introduction</h3><div>Individuals with schizophrenia commonly exhibit cognitive biases that are related to the disorder's symptoms.</div></div><div><h3>Objective</h3><div>To review the current evidence on the characteristics and efficacy of psychological interventions targeting cognitive biases in individuals with schizophrenia.</div></div><div><h3>Method</h3><div>Systematic review registered in PROSPERO. A bibliographic search was conducted in PsycINFO, PubMed, Scopus, and Web of Science up to January 2024. The search focused on quantitative studies using the following keyword sequence: (schizophreni* OR psychosis OR psychoses OR psychotic*) AND (cogniti* OR think*) AND (bias* OR error*) AND (treatment OR therapy OR intervention OR training).</div></div><div><h3>Results</h3><div>A total of 38 studies assessed psychological interventions targeting cognitive biases in schizophrenia, with most focusing on Metacognitive Training (MCT). These interventions were found to significantly improve cognitive biases and positive symptoms, with promising effects on other symptoms,such as insight, negative symptoms, or self-esteem.</div></div><div><h3>Conclusions</h3><div>The evidence linking cognitive biases to schizophrenia symptomatology is reinforced. Additionally, it is shown that improving cognitive biases may be an important therapeutic goal in the treatment of the disorder.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100304"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Difference in degree centrality of brain functional connectivity between patients with treatment-resistant depression and patients with non-treatment-resistant depression compared with healthy individuals","authors":"Li-Kai Cheng ,&nbsp;Li-Fen Chen ,&nbsp;Tung-Ping Su ,&nbsp;Cheng-Ta Li ,&nbsp;Wei-Chen Lin ,&nbsp;Shih-Jen Tsai ,&nbsp;Ya-Mei Bai ,&nbsp;Pei-Chi Tu ,&nbsp;Mu-Hong Chen","doi":"10.1016/j.ejpsy.2025.100292","DOIUrl":"10.1016/j.ejpsy.2025.100292","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Evidence suggests that treatment-resistant depression (TRD) is associated with more prominent and widespread brain alterations in areas related to mood and cognition compared with non-treatment-resistant depression (nTRD). However, direct comparisons of brain functioning between TRD and nTRD are scarce.</div></div><div><h3>Methods</h3><div>We applied graph theory-based resting-state functional magnetic resonance imaging analysis to compare the degree centrality (DC) of brain functional connectivity among 31 patients with TRD, 28 patients with nTRD, and 30 healthy controls. Cognitive function was assessed using working memory and go/no-go tasks.</div></div><div><h3>Results</h3><div>Compared with controls, patients with TRD exhibited reduced DC in the left cuneus, right frontal operculum cortex, cerebellum vermis I, II, and IX, and left cerebellum lobule X. The DC in the right cerebellum lobule III was lower in patients with TRD compared with those with nTRD. Among patients with TRD, we discovered positive associations between mean reaction time on the go/no-go task and DC in the left cuneus (<em>r</em> = 0.44, <em>p</em> = 0.015) and the right frontal operculum cortex (<em>r</em> = 0.41, <em>p</em> = 0.025). Conversely, the mean reaction time on the working memory task was inversely correlated with DC in the left cerebellar lobule X (<em>r</em> = −0.43, <em>p</em> = 0.019).</div></div><div><h3>Conclusion</h3><div>Our findings highlight the important roles of the cerebellum (specifically, lobule X, and the right lobule III), frontal operculum, and cuneus in TRD. Dysfunction in these brain regions, which are integral to the salience and default mode networks, is likely associated with TRD-related cognitive dysfunction.</div></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":"39 3","pages":"Article 100292"},"PeriodicalIF":2.5,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143136443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}