Carlota Moya-Lacasa , Leticia González-Blanco , Manuel Couce-Sánchez , Clara Martínez-Cao , Gonzalo Paniagua , Paula Zurrón-Madera , Belén Arranz , Gemma Safont , Pilar Sierra , María Paz García-Portilla
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The score on the sleep domain of the Hamilton Depression Rating Scale (HDRS_sleep) was used to evaluate current sleep disturbances. Other psychometric tests, such as the Young Mania Rating Scale or the Hamilton Anxiety Rating Scale, were used to assess clinical status. Sociodemographic and other clinical variables were collected. Statistical analysis was performed using IBM SPSS Statistics, Version 27.0. Non-parametric tests and multiple linear regression were used.</p></div><div><h3>Results</h3><p>Of the 291 patients included in the study, 64.3 % (<em>n</em> = 187) were women. Mean age was 47.86 (SD=12.693). The sample was segmented into two groups: euthymia and non-euthymia, and the analysis was carried out separately in each. We observed no differences in either of these groups in HDRS_sleep with regard to sex, age, metabolic syndrome, coffee intake, or smoking. After adjusting for covariates, anxiety and functionality were significantly related to sleep in the non-euthymia group.</p></div><div><h3>Conclusions</h3><p>Sleep disturbances are frequent in BD, even during euthymia. Its impact on functionality and anxiety levels highlights the importance of targeting sleep in clinical practice to improve the outcome of the disorder.</p></div>","PeriodicalId":12045,"journal":{"name":"European Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0213616324000144/pdfft?md5=912ed311cb8db3d82a43a49c528f4d7a&pid=1-s2.0-S0213616324000144-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Impact of sleep on clinical outcomes in a cohort of patients with bipolar disorder\",\"authors\":\"Carlota Moya-Lacasa , Leticia González-Blanco , Manuel Couce-Sánchez , Clara Martínez-Cao , Gonzalo Paniagua , Paula Zurrón-Madera , Belén Arranz , Gemma Safont , Pilar Sierra , María Paz García-Portilla\",\"doi\":\"10.1016/j.ejpsy.2024.100264\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and Objectives</h3><p>Sleep disturbances are part of the diagnostic criteria for bipolar disorder (BD). They are prodromal symptoms of the disorder and are present during relapse and euthymia. We aimed to identify the impact of sleep, as an endophenotype, on BD patients in terms of clinical features including suicidality, severity of the disorder, somatic comorbidities, and functionality.</p></div><div><h3>Methods</h3><p>This is a secondary analysis of a cross-sectional study including 291 outpatients during follow-up at four sites in Spain. The score on the sleep domain of the Hamilton Depression Rating Scale (HDRS_sleep) was used to evaluate current sleep disturbances. Other psychometric tests, such as the Young Mania Rating Scale or the Hamilton Anxiety Rating Scale, were used to assess clinical status. Sociodemographic and other clinical variables were collected. Statistical analysis was performed using IBM SPSS Statistics, Version 27.0. Non-parametric tests and multiple linear regression were used.</p></div><div><h3>Results</h3><p>Of the 291 patients included in the study, 64.3 % (<em>n</em> = 187) were women. Mean age was 47.86 (SD=12.693). The sample was segmented into two groups: euthymia and non-euthymia, and the analysis was carried out separately in each. We observed no differences in either of these groups in HDRS_sleep with regard to sex, age, metabolic syndrome, coffee intake, or smoking. After adjusting for covariates, anxiety and functionality were significantly related to sleep in the non-euthymia group.</p></div><div><h3>Conclusions</h3><p>Sleep disturbances are frequent in BD, even during euthymia. 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Impact of sleep on clinical outcomes in a cohort of patients with bipolar disorder
Background and Objectives
Sleep disturbances are part of the diagnostic criteria for bipolar disorder (BD). They are prodromal symptoms of the disorder and are present during relapse and euthymia. We aimed to identify the impact of sleep, as an endophenotype, on BD patients in terms of clinical features including suicidality, severity of the disorder, somatic comorbidities, and functionality.
Methods
This is a secondary analysis of a cross-sectional study including 291 outpatients during follow-up at four sites in Spain. The score on the sleep domain of the Hamilton Depression Rating Scale (HDRS_sleep) was used to evaluate current sleep disturbances. Other psychometric tests, such as the Young Mania Rating Scale or the Hamilton Anxiety Rating Scale, were used to assess clinical status. Sociodemographic and other clinical variables were collected. Statistical analysis was performed using IBM SPSS Statistics, Version 27.0. Non-parametric tests and multiple linear regression were used.
Results
Of the 291 patients included in the study, 64.3 % (n = 187) were women. Mean age was 47.86 (SD=12.693). The sample was segmented into two groups: euthymia and non-euthymia, and the analysis was carried out separately in each. We observed no differences in either of these groups in HDRS_sleep with regard to sex, age, metabolic syndrome, coffee intake, or smoking. After adjusting for covariates, anxiety and functionality were significantly related to sleep in the non-euthymia group.
Conclusions
Sleep disturbances are frequent in BD, even during euthymia. Its impact on functionality and anxiety levels highlights the importance of targeting sleep in clinical practice to improve the outcome of the disorder.
期刊介绍:
The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.