睡眠对双相情感障碍患者临床疗效的影响

IF 2.5 4区 医学 Q2 PSYCHIATRY
Carlota Moya-Lacasa , Leticia González-Blanco , Manuel Couce-Sánchez , Clara Martínez-Cao , Gonzalo Paniagua , Paula Zurrón-Madera , Belén Arranz , Gemma Safont , Pilar Sierra , María Paz García-Portilla
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引用次数: 0

摘要

背景和目的睡眠障碍是躁郁症(BD)诊断标准的一部分。睡眠障碍是躁郁症的前驱症状,在复发和健康状态时也会出现。我们的目的是确定睡眠作为一种内表型对双相情感障碍患者临床特征的影响,包括自杀倾向、障碍严重程度、躯体合并症和功能性。汉密尔顿抑郁评定量表(HDRS_sleep)睡眠领域的得分用于评估当前的睡眠障碍。其他心理测试,如青年躁狂评定量表(Young Mania Rating Scale)或汉密尔顿焦虑评定量表(Hamilton Anxiety Rating Scale)则用于评估临床状态。此外,还收集了社会人口学变量和其他临床变量。统计分析使用 IBM SPSS 统计软件 27.0 版进行。结果 在纳入研究的 291 名患者中,64.3%(n = 187)为女性。平均年龄为 47.86 岁(SD=12.693)。样本分为两组:优生组和非优生组,分别进行分析。我们观察到这两组的 HDRS_sleep 在性别、年龄、代谢综合征、咖啡摄入量或吸烟方面均无差异。在调整协变量后,非亢进组的焦虑和功能与睡眠显著相关。它对功能和焦虑水平的影响凸显了在临床实践中以睡眠为目标来改善该疾病预后的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of sleep on clinical outcomes in a cohort of patients with bipolar disorder

Background and Objectives

Sleep disturbances are part of the diagnostic criteria for bipolar disorder (BD). They are prodromal symptoms of the disorder and are present during relapse and euthymia. We aimed to identify the impact of sleep, as an endophenotype, on BD patients in terms of clinical features including suicidality, severity of the disorder, somatic comorbidities, and functionality.

Methods

This is a secondary analysis of a cross-sectional study including 291 outpatients during follow-up at four sites in Spain. The score on the sleep domain of the Hamilton Depression Rating Scale (HDRS_sleep) was used to evaluate current sleep disturbances. Other psychometric tests, such as the Young Mania Rating Scale or the Hamilton Anxiety Rating Scale, were used to assess clinical status. Sociodemographic and other clinical variables were collected. Statistical analysis was performed using IBM SPSS Statistics, Version 27.0. Non-parametric tests and multiple linear regression were used.

Results

Of the 291 patients included in the study, 64.3 % (n = 187) were women. Mean age was 47.86 (SD=12.693). The sample was segmented into two groups: euthymia and non-euthymia, and the analysis was carried out separately in each. We observed no differences in either of these groups in HDRS_sleep with regard to sex, age, metabolic syndrome, coffee intake, or smoking. After adjusting for covariates, anxiety and functionality were significantly related to sleep in the non-euthymia group.

Conclusions

Sleep disturbances are frequent in BD, even during euthymia. Its impact on functionality and anxiety levels highlights the importance of targeting sleep in clinical practice to improve the outcome of the disorder.

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来源期刊
CiteScore
2.90
自引率
0.00%
发文量
40
审稿时长
43 days
期刊介绍: The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.
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