关于理想的氯氮平特异性副作用量表特征的德尔菲专家共识

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2024-07-08 DOI:10.1016/j.ejpsy.2024.100267

Emilio Fernández-Egea

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引用次数: 0

摘要

本研究采用德尔菲法确定氯氮平药物不良反应量表的理想特征，34 位氯氮平专家参加了第六届 NEMEA 会议。与会者强调应将临床医生评分（CROM）和患者评分（PROM）结果纳入量表，力求在全面性和实用性之间取得平衡。主要的共识包括纳入特定的不良反应，如嗜睡、鼻出血和强迫症，而代谢并发症则被认为不太相关。这项研究强调，需要一种实用的、包含患者的工具来监测氯氮平的不良反应，这种工具既要反映临床专业知识，又要反映患者在治疗耐药精神分裂症过程中的经验。

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An expert Delphi consensus for the characteristics of an ideal clozapine-specific side effect scale

This study employed the Delphi method to identify the ideal characteristics of a clozapine adverse drug reaction (ADR) scale, engaging 34 clozapine specialists at the 6th NEMEA meeting. Participants emphasized the integration of clinician-rated (CROM) and patient-rated (PROM) outcomes in the scale, aiming for a balance between comprehensiveness and practicality. Key consensus points included the inclusion of specific ADRs like somnolence, sialorrhea, and compulsivity, while metabolic complications were considered less relevant. This research highlights the need for a practical, patient-inclusive tool for monitoring clozapine ADRs, reflective of both clinical expertise and patient experiences in managing treatment-resistant schizophrenia.

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.