以改善生活方式为基础的抗药性抑郁症干预治疗反应中的性别差异

IF 2.5 4区医学 Q2 PSYCHIATRY

European Journal of Psychiatry Pub Date : 2024-04-30 DOI:10.1016/j.ejpsy.2024.100254

Alejandra Aguilar-Latorre , Margalida Gili , Capilla Navarro-Guzmán , Aurora Garcia , Aina M. Yáñez , Mauro Garcia-Toro

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引用次数: 0

摘要

难治性抑郁症（TRD）是一项重大的社会挑战，其治疗差距因性别而异。在一项针对TRD的临床试验中，我们引入了基于生活方式的干预措施。本研究分析了24名男性和70名女性TRD患者的数据，旨在评估与性别相关的疗效差异。描述性分析和单变量分析揭示了社会人口学和临床因素的差异。在控制基线值和年龄的同时，利用重复测量方差分析，结果显示出明显的性别差异。具体来说，女性抑郁症状的进展明显较慢。这凸显了在TRD治疗中针对不同性别的细微差别采取针对性干预措施的必要性。

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Gender differences in the therapeutic response to lifestyle improvement-based interventions for treatment-resistant depression

Treatment-resistant depression (TRD) poses a significant societal challenge, with gender-specific treatment gaps. In a clinical trial targeting TRD, we introduced lifestyle-based interventions. Analyzing data from 24 men and 70 women with TRD, the current study aimed to assess gender-related efficacy differences. Descriptive and univariate analyses unveiled variations in sociodemographic and clinical factors. Utilizing repeated measures ANOVA while controlling for baseline values and age, results indicated a notable gender disparity. Specifically, women exhibited a significantly poorer progression of depressive symptoms. This underscores the need for tailored interventions addressing gender-specific nuances in TRD treatment.

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来源期刊

European Journal of Psychiatry PSYCHIATRY-

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

43 days

期刊介绍： The European journal of psychiatry is a quarterly publication founded in 1986 and directed by Professor Seva until his death in 2004. It was originally intended to report “the scientific activity of European psychiatrists” and “to bring about a greater degree of communication” among them. However, “since scientific knowledge has no geographical or cultural boundaries, is open to contributions from all over the world”. These principles are maintained in the new stage of the journal, now expanded with the help of an American editor.