European Journal of Nutrition最新文献

{"title":"Development of metabolic signatures of plant-rich dietary patterns using plant-derived metabolites.","authors":"Yong Li, Yifan Xu, Melanie Le Sayec, Tim D Spector, Claire J Steves, Cristina Menni, Rachel Gibson, Ana Rodriguez-Mateos","doi":"10.1007/s00394-024-03511-x","DOIUrl":"10.1007/s00394-024-03511-x","url":null,"abstract":"<p><strong>Background: </strong>Diet is an important modifiable lifestyle factor for human health, and plant-rich dietary patterns are associated with lower risk of non-communicable diseases in numerous studies. However, objective assessment of plant-rich dietary exposure in nutritional epidemiology remains challenging.</p><p><strong>Objectives: </strong>This study aimed to develop and evaluate metabolic signatures of the most widely used plant-rich dietary patterns using a targeted metabolomics method comprising 108 plant food metabolites.</p><p><strong>Methods: </strong>A total of 218 healthy participants were included, aged 51.5 ± 17.7 years, with 24 h urine samples measured using ultra-high-performance liquid chromatography-mass spectrometry. The validation dataset employed three sample types to test the robustness of the signature, including 24 h urine (n = 88), plasma (n = 195), and spot urine (n = 198). Adherence to the plant-rich diet was assessed using a priori plant-rich dietary patterns calculated using Food Frequency Questionnaires. A combination of metabolites evaluating the adherence to a specific diet was identified as metabolic signature. We applied linear regression analysis to select the metabolites significantly associated with dietary patterns (adjusting energy intake), and ridge regression to estimate penalized weights of each candidate metabolite. The correlation between metabolic signature and the dietary pattern was assessed by Spearman analysis (FDR < 0.05).</p><p><strong>Results: </strong>The metabolic signatures consisting of 42, 22, 35, 15, 33, and 33 predictive metabolites across different subclasses were found to be associated with adherence to Amended Mediterranean Score (A-MED), Original MED (O-MED), Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND), healthy Plant-based Diet Index (hPDI) and unhealthy PDI (uDPI), respectively. The overlapping and distinct predictive metabolites across six dietary patterns predominantly consisted of phenolic acids (n = 38), including 14 cinnamic acids, 14 hydroxybenzoic acids, seven phenylacetic acids, and three hippuric acids. Six metabolites were included in all signatures, including two lignans: enterolactone-glucuronide, enterolactone-sulfate, and four phenolic acids: cinnamic acid, cinnamic acid-4'-sulfate, 2'-hydroxycinnamic acid, and 4-methoxybenzoic acid-3-sulfate. The established signatures were robustly correlated with dietary patterns in the validation datasets (r = 0.13-0.40, FDR < 0.05).</p><p><strong>Conclusions: </strong>We developed and evaluated a set of metabolic signatures that reflected the adherence to plant-rich dietary patterns, suggesting the potential of these signatures to serve as an objective assessment of free-living eating habits.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"29"},"PeriodicalIF":4.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactobacillus reuteri TISTR 2736 alleviates type 2 diabetes in rats via the hepatic IRS1/PI3K/AKT signaling pathway by mitigating oxidative stress and inflammatory mediators.","authors":"Kamonthip Pakaew, Pennapa Chonpathompikunlert, Navinee Wongmanee, Worarat Rojanaverawong, Jaruwan Sitdhipol, Punnathorn Thaveethaptaikul, Natthawut Charoenphon, Wanthanee Hanchang","doi":"10.1007/s00394-024-03529-1","DOIUrl":"https://doi.org/10.1007/s00394-024-03529-1","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigated the beneficial effects of Lactobacillus reuteri TISTR 2736 on glucose homeostasis, carbohydrate metabolism, and the underlying mechanisms of its actions in type 2 diabetic (T2D) rats.</p><p><strong>Methods: </strong>A rat model of T2D was established by a combination of a high-fat diet and streptozotocin. The diabetic rats were treated daily with L. reuteri TISTR 2736 (2 × 10⁸ CFU/day) for 30 days. Biochemical, histopathological, and molecular analyses were carried out to determine insulin signaling, carbohydrate metabolism, oxidative stress, and inflammation.</p><p><strong>Results: </strong>The results demonstrated that treatment with L. reuteri TISTR 2736 significantly ameliorated fasting blood glucose and glucose intolerance, and improved insulin sensitivity indices in the diabetic rats. The hepatic histopathology was improved with L. reuteri TISTR 2736 treatment, which was correlated with a reduction of hepatic lipid profiles. L. reuteri TISTR 2736 significantly reduced glycogen content, fructose 1,6-bisphosphatase activity, and phosphoenolpyruvate carboxykinase 1 protein expression, and enhanced hexokinase activity in the diabetic liver. The downregulation of IRS1 and phosphorylated IRS1^Ser307 and upregulation of PI3K and phosphorylated AKT^Ser473 proteins in the liver were found in the L. reuteri TISTR 2736-treated diabetic group. Furthermore, it was able to suppress oxidative stress and inflammation in the diabetic rats, as demonstrated by decreased malondialdehyde and protein levels of NF-κB, IL-6 and TNF-α, but increased antioxidant enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase.</p><p><strong>Conclusion: </strong>By inhibiting oxidative and inflammatory stress, L. reuteri TISTR 2736 alleviated hyperglycemia and improved carbohydrate metabolism through activating IRS1/PI3K/AKT pathway in the T2D rats.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"27"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary fat intakes, food sources, and tracking across early childhood: results from the Melbourne InFANT Program.","authors":"Tinsae Shemelise Tesfaye, Ewa A Szymlek-Gay, Karen J Campbell, Miaobing Zheng","doi":"10.1007/s00394-024-03509-5","DOIUrl":"https://doi.org/10.1007/s00394-024-03509-5","url":null,"abstract":"<p><strong>Purpose: </strong>Despite the important role of dietary fat in early childhood, our understanding of fat intake trends during this period is limited, particularly among Australian children. This study aimed to describe total and saturated fat (SFA) intake trends, food sources, and tracking in young Australian children.</p><p><strong>Methods: </strong>Data of children at ages 9 months (n = 393), 18 months (n = 284), 3.5 years (n = 244), and 5 years (n = 240) from the Melbourne InFANT Program were used. Dietary intakes were collected via three 24-hour recalls. Food groups and nutrient intakes were calculated using the 2007 AUSNUT Food Composition Database. Descriptive statistics were used to summarize fat intake and key food sources of fat. Tracking of fat intake was examined using Pearson correlations of residualized fat scores between time points.</p><p><strong>Results: </strong>Total and SFA intake (g/d) increased over time in early childhood. The percentage of energy from total fat decreased from 9 to 18 months but remained stable until 5 years of age. The percentage of energy from SFA decreased across early childhood. Milk and milk products were the primary sources of both total fat and SFA, followed by breads/cereals, and cakes/cookies. Slight to moderate tracking of fat was observed in most age groups.</p><p><strong>Conclusion: </strong>This study described trends and food sources of young children's fat intakes and showed that early fat intakes track up to age 5 years. The study will contribute to the development and refinement of fat recommendations in young Australian children and inform the design of interventions to improve fat intake.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"24"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high-pressure-processed rice intake during interval walking training on glycemic control and NFKB2 gene methylation in hyperglycemic older people.","authors":"Takamichi Aida, Shizue Masuki, Mayuko Morikawa, Kazumasa Manabe, Mayuka Furihata, Aki Maekawa, Tomoyuki Fujita, Hiroshi Nose","doi":"10.1007/s00394-024-03536-2","DOIUrl":"10.1007/s00394-024-03536-2","url":null,"abstract":"<p><strong>Purpose: </strong>High-pressure-processed (HPP) rice is white rice that maintains some key functional food ingredients of brown rice, such as polyphenols. We examined whether HPP rice intake during interval walking training (IWT) improved glycemic control with enhanced methylation of the NFKB2 gene in hyperglycemic older subjects.</p><p><strong>Methods: </strong>We recruited 51 people aged ~ 70 yr who had already performed IWT for ≥ 6 months, but had hyperglycemia (blood glucose concentration ([Glc]) > 110 mg/dl or HbA1c > 6.0% while fasting). Participants were randomly divided into control (CNT) or HPP rice (HPR) groups and instructed to perform IWT for an additional 4 months while ingesting 75 g dry weight of either white rice or HPP rice, respectively, at every breakfast and dinner. Before and after intervention, [Glc] was measured by continuous glucose monitoring for 5 days, with standardized breakfast on day 5. Methylation of NFKB2 was measured by pyrosequencing.</p><p><strong>Results: </strong>After intervention, mean fasting [Glc] values for 180 min before breakfast over 4 days (days 2-5) marginally decreased in HPR but were not different from CNT (P = 0.17). However, the standard deviation during the period decreased more in HPR than in CNT (P = 0.013). Moreover, total area under the curve (tAUC) for 180 min after breakfast on day 5 decreased more in HPR than in CNT (P = 0.035). The change in tAUC on day 5 after the intervention was negatively correlated with that in NFKB2 gene methylation (P = 0.002).</p><p><strong>Conclusion: </strong>HPP rice intake during IWT improved glycemic control with suppressed reduction in NFKB2 gene methylation in hyperglycemic older people.</p><p><strong>Trial registration number and date of registration: </strong>UMIN000024390; October 13, 2016.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"26"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of 3-month supplementation with synbiotic on patient-reported outcomes, exercise tolerance, and brain and muscle metabolism in adult patients with post-COVID-19 chronic fatigue syndrome (STOP-FATIGUE): a randomized Placebo-controlled clinical trial.","authors":"Marijana Ranisavljev, Valdemar Stajer, Nikola Todorovic, Jelena Ostojic, Jelena Helena Cvejic, Robert E Steinert, Sergej M Ostojic","doi":"10.1007/s00394-024-03546-0","DOIUrl":"10.1007/s00394-024-03546-0","url":null,"abstract":"<p><strong>Purpose: </strong>Considering the observed gastrointestinal issues linked to post-COVID-19 myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), beneficially modulating the gut microbiota could offer a safe, cost-effective nutritional strategy. This trial aimed to evaluate the effects of medium-term synbiotic supplementation on patient-reported outcomes, exercise tolerance, and tissue metabolism in patients with post-COVID-19 ME/CFS.</p><p><strong>Methods: </strong>Between September 2022 and December 2023, we investigated the impact of 3-month supplementation with a synbiotic mixture including L. rhamnosus DSM 32550, Humiome® L. plantarum DSM 34532, B. lactis DSM 32269, B. longum DSM 32946, fructooligosaccharides and zinc, on predetermined primary and secondary outcome measures in twenty six post-COVID-19 ME/CFS patients utilizing a parallel-group, randomized, placebo-controlled, double-blind design.</p><p><strong>Results: </strong>Both the synbiotic and placebo intake resulted in a significant reduction in general fatigue after 3 months compared to the baseline values (P ≤ 0.05). This was accompanied by a significant interaction effect (time vs. treatment) for post-exercise malaise (P = 0.02), with synbiotic superior to placebo to attenuate post-exercise malaise. The synbiotic also demonstrated a significant advantage over placebo in increasing choline levels at the thalamus (P = 0.02), and creatine levels at left frontal white matter (P = 0.05) and left frontal grey matter (P = 0.04).</p><p><strong>Conclusion: </strong>Taking the synbiotic mixture for three months improves tissue metabolism and mitigates clinical features of post-COVID-19 fatigue syndrome. The presented data show promise in addressing the widespread issue of ME/CFS following the COVID-19 pandemic; however, further validation is needed before endorsing the synbiotics within this clinical context. The study is registered at ClinicalTrials.gov (NCT06013072).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"28"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal insulinemic and inflammatory dietary patterns and risk of child neurodevelopmental delay.","authors":"Haixia Wang, Ping Zu, Wanjun Yin, Lei Zhang, Liang Ruan, Xianxia Chen, Peng Zhu","doi":"10.1007/s00394-024-03531-7","DOIUrl":"https://doi.org/10.1007/s00394-024-03531-7","url":null,"abstract":"<p><strong>Purpose: </strong>Our aim was to assess the risk of higher insulinemic, inflammatory, and hyperglycemia potential in the diet during pregnancy with child neurodevelopmental delay.</p><p><strong>Methods: </strong>We enrolled 7,438 pregnant women participating in a prospective cohort study. The food frequency questionnaire was used to evaluate the empirical dietary index for hyperinsulinemia (EDIH), empirical dietary inflammatory pattern (EDIP), glycemic index (GI), and glycemic load (GL) during mid-pregnancy. Child neurodevelopmental assessment was conducted at 6-36 months postpartum using the Denver Developmental Screening Test-II (DDST-II) scale, and the Gesell Developmental Diagnosis Scale (GDDS) was administered to assess children who did not meet the criteria for passing the DDST-II screening.</p><p><strong>Results: </strong>We documented 540 incident child neurodevelopmental delay cases over 7,438 pregnant women (median follow-up: 2 years). Pregnant women exhibiting the high levels of hyperinsulinemic or proinflammatory components, or GI encountered an elevated risk of child neurodevelopmental delay; HRs (95% CI) comparing highest to lowest dietary index quintiles were EDIH 1.48 (1.07,2.04; P _trend = 0.017), EDIP 1.39 (1.05,1.84; P _trend = 0.019) and GI 1.36 (1.02,1.81; P _trend = 0.038). In sex-stratified analyses, these results remained significant only in boys (P _trend = 0.018 for EDIH, P _trend = 0.028 for EDIP, P _trend = 0.029 for GI). The performance of combined model of EDIH and EDIP for boys is comparable to that of the combined model of EDIH, EDIP, and GI to assess the risk of neurodevelopmental delay (AUC [area under curve] 0.801 vs. AUC 0.830). Both values are higher than the AUC values achieved by models using either set of indicators individually.</p><p><strong>Conclusion: </strong>Our findings suggest that maternal consumption of diets with high insulinemic, inflammatory, or glycemic index properties may be associated with neurodevelopmental delays in children, particularly in boys. Higher insulinemic and inflammatory potentials in maternal diet may forecast neurodevelopmental delay in boys.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"25"},"PeriodicalIF":4.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the evening carbohydrate dilemma: the effect of within-the-day carbohydrate periodization on body composition and physical fitness.","authors":"Angelos Vlahoyiannis, Eleni Andreou, George Aphamis, Kyriakos Felekkis, Myrtani Pieri, Giorgos K Sakkas, Christoforos D Giannaki","doi":"10.1007/s00394-024-03540-6","DOIUrl":"https://doi.org/10.1007/s00394-024-03540-6","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the effects of carbohydrate timing and type on body composition and physical fitness.</p><p><strong>Methods: </strong>Forty-two healthy, trained male volunteers underwent a four-week intervention, randomly divided into three groups: (i) Sleep Low-No Carbohydrates (SL-NCHO): consuming all carbohydrate intake at regular intervals prior to evening training, (ii) Sleep High-Low Glycemic Index (SH-LGI), and (iii) Sleep High-High Glycemic Index (SH-HGI). In both SH-LGI and SH-HGI, carbohydrates were distributed throughout the day, both pre-(60% of total intake) and post-evening training (40% of total intake). The SH-LGI and SH-HGI groups diverged in evening carbohydrate quality, featuring LGI and HGI foods, respectively. All participants performed a standardized exercise program combining resistance exercise and high-intensity interval training. Body composition was assessed using skinfold measurements and bioelectrical impendence analysis. Physical fitness was assessed by measuring VO₂max, Visual Reaction Time (VRT), Countermovement Jump (CMJ), and 1-repetition maximum (1RM) in hack squat, chest press, shoulder press, and lat-pulldown exercises.</p><p><strong>Results: </strong>There was a significant time-effect on both body composition and physical fitness indices. Bodyfat percentage decreased by an average of 1.5% (p < 0.001), fat-mass by 1.4 kg (p < 0.001) and fat-free mass increased by 0.9 kg (p = 0.006). A time-effect was also observed in VO₂max, CMJ, 1RM testing, and VRT (all p < 0.05). There were no significant differences among interventions.</p><p><strong>Conclusions: </strong>A balanced dietary plan with sufficient nutrient and energy intake promotes body composition optimization and physical fitness, independently of carbohydrate type or timing. This study points towards implementing flexible nutrition interventions, emphasizing the potential of tailored dietary strategies to optimize health and physical fitness.</p><p><strong>Trial registration number: </strong>The trial was registered at clinicaltrials.gov as NCT05464342.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"23"},"PeriodicalIF":4.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between Chinese adapted MIND diet and cognitive function in Chinese middle-aged and older adults: results from the Chinese Square Dance Cohort.","authors":"Likang Lu, Silong Cai, Qing Xiao, Jianying Peng, Fengping Li, Yuanyuan Li, Benchao Li, Tingting Li, Shuang Rong","doi":"10.1007/s00394-024-03522-8","DOIUrl":"10.1007/s00394-024-03522-8","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the relationship between Chinese adapted MIND diet and cognitive functioning and performance in different cognitive domains across a cross-section of Chinese middle-aged and older adults.</p><p><strong>Methods: </strong>This cross-sectional study used baseline data from the Lifestyle and Healthy Ageing in Chinese Square Dancers study. Chinese adapted MIND diet scores were calculated from a detailed retrospective semi-quantitative food frequency questionnaire assessment. By averaging the z-scores of Auditory Verbal Learning Test (AVLT), Verbal Fluency Test (VFT), Digital Symbol Substitution Test (DSST), and Trail Making Test-B (TMT-B), a comprehensive z-score is obtained to represent global cognition. Mild cognitive impairment (MCI) was diagnosed based on Petersen's criteria. Multiple linear regression models were used to analyze the relationship between Chinese adapted MIND diet scores and z-scores of cognitive functions, and multiple logistic regression models were used to assess the association between diet scores and MCI.</p><p><strong>Results: </strong>In this study, a total of 4335 participants were included, whose mean age was 63.61 years (SD = 5.15), 85.07% were female, and 13.33% (578/4335) of them had MCI. In the fully adjusted model, the group with the highest diet scores had the best cognitive function compared to the group with the lowest diet scores (P < 0.05), including global cognitive function (β = 0.10, 95% CI: 0.05, 0.15), AVLT (β = 0.12, 95% CI: 0.03, 0.20), VFT (β = 0.12, 95% CI: 0.03, 0.20), DSST (β = 0.07, 95% CI: 0.00, 0.14), and TMT-B (β =-0.10, 95% CI: -0.18, -0.01). In addition, compared to the lowest group, the highest diet scores group were associated with lower odd ratio of MCI (OR = 0.69, 95% CI: 0.51, 0.93).</p><p><strong>Conclusions: </strong>Our findings support that higher adherence to Chinese adapted MIND diet is associated with better cognitive function and lower prevalence odds ratio for MCI in a Chinese middle-aged and older population.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"22"},"PeriodicalIF":4.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthohumol ameliorates dextran sodium sulfate-induced colitis in mice by inhibiting of NF-κB signaling pathways and modulating intestinal microbiota.","authors":"Ning Han, Jie Li, Yangyang Li, Feiei Zhao, Jun Wang, Peiyu Ye, Zhenling Zeng","doi":"10.1007/s00394-024-03525-5","DOIUrl":"10.1007/s00394-024-03525-5","url":null,"abstract":"<p><strong>Ethnopharmacological relevance: </strong>Xanthohumol (XN), an isoprenylated flavonoid natural product found only in hops, possesses a variety of biological activities such as anticancer, anti-inflammatory, hepatoprotective, and anti-obesity.</p><p><strong>Aim of the study: </strong>The aim of this study was to investigate the effects and mechanisms of XN on the treatment of colitis.</p><p><strong>Materials and methods: </strong>First, acute colitis was induced by using distilled water containing 3% DSS for 10 consecutive days. The therapeutic efficacy of XN was assessed by an established DSS-induced mouse colitis model. Subsequently, disease activity index (DAI) and colon length of mice were assessed. The health of the intestines was assessed by histopathological analysis. Inflammatory factors, IL-1β, IL-6, and TNF-α, were detected in colon tissues by ELISA.Finally, mouse intestinal contents were extracted and subjected to 16 S rRNA Sequencing, and the gut microbiota was analysed for Alpha-diversity and Beta-diversity.</p><p><strong>Results: </strong>The results showed that XN ameliorated DSS-induced colitis. Furthermore, XN reduced pro-inflammatory cytokine levels such as IL-1β, IL-6, and TNF-α, as well as inhibited the activation of the TLR4/NF-κB pathway, all of which helped to mitigate the inflammatory response. Finally, we also found that XN alleviated intestinal dysbiosis in colitis mice.</p><p><strong>Conclusion: </strong>In conclusion, our study demonstrated that XN provides protective effects against colitis, and has the potential to be further explored as a lead compound for the treatment of inflammatory bowel disease (IBD).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"21"},"PeriodicalIF":4.1,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre- and post-polyphenol intake and ovarian cancer survival: evidence from a prospective cohort study.","authors":"Jia-Nan Sun, Yu Li, Meng Luan, Lang Wu, Fang-Hua Liu, Yi-Zi Li, He-Li Xu, Yi-Fan Wei, Qian Xiao, Xiao-Ying Li, Jin Xu, Ke-Xin Liu, Dong-Hui Huang, Qi-Jun Wu, Ting-Ting Gong","doi":"10.1007/s00394-024-03516-6","DOIUrl":"https://doi.org/10.1007/s00394-024-03516-6","url":null,"abstract":"<p><strong>Purpose: </strong>Although (poly)phenols have shown potential in anti-cancer activities, their impact on improving ovarian cancer (OC) survival remains unknown. Therefore, we aim to first investigate the association between dietary polyphenol intake and OC survival, providing valuable insights into potential interventions.</p><p><strong>Methods: </strong>The prospective cohort recruited 560 patients with OC to assess the associations of polyphenol intake, not only pre- and post-diagnosis but also the change from pre- to post-diagnosis with OC survival. Dietary intakes of total (poly)phenols and their five classes (flavonoids, phenolic acids, lignans, stilbenes, and other polyphenols) were assessed using a validated 111-item food frequency questionnaire. Overall survival (OS) was tracked through active follow-up and medical records until February 16th, 2023. Cox proportional hazard regression models were applied to calculate the hazard ratios (HR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>During a median follow-up of 44.4 months, 211 all-cause deaths were identified. We observed significant associations between higher polyphenol intake with lower risk of mortality among patients with OC ((HR _{T3 vs. T1} = 0.55, 95%CI = 0.35-0.87 for pre-diagnosis; and HR _{T3 vs. T1} = 0.59, 95%CI = 0.39-0.90 for post-diagnosis). Consistently, an evident linear trend was observed for polyphenol and flavonoid intake with OC survival. Of note, compared to the stable group (change within 10%), the decreased intake (change of more than 10%) of total (poly)phenols and five polyphenol classes was significantly associated with worse OS.</p><p><strong>Conclusion: </strong>Dietary (poly)phenols, as well as its five classes, have an inverse association with OC survival.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 1","pages":"14"},"PeriodicalIF":4.1,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}