European Journal of Nutrition最新文献

{"title":"Association between ultra-processed food consumption and inflammation: insights from the STANISLAS cohort.","authors":"Lea Lin Chun Hu Xia, Nicolas Girerd, Zohra Lamiral, Kevin Duarte, Ludovic Merckle, Celine Leroy, Julie-Anne Nazare, Laurie Van Den Berghe, Louise Seconda, Axelle Hoge, Michèle Guillaume, Martine Laville, Patrick Rossignol, Jean-Marc Boivin, Sandra Wagner","doi":"10.1007/s00394-025-03607-y","DOIUrl":"10.1007/s00394-025-03607-y","url":null,"abstract":"<p><strong>Purpose: </strong>High consumption of ultra-processed food (UPF) is associated with an increased risk of developing chronic diseases. Inflammation may be one of the underlying mechanisms behind this association. However, only a limited number of studies have investigated the association between UPF consumption and a few selected inflammation biomarkers, yielding inconsistent results. This study aimed to assess the cross-sectional association between UPF consumption (as a whole and 10 sub-categories), and 78 circulating proteins related to inflammation.</p><p><strong>Methods: </strong>The present study included 1594 adult participants from the STANISLAS cohort. UPF consumption was estimated using the NOVA classification, and linear regression models were used to assess their association with circulating proteins.</p><p><strong>Results: </strong>UPFs accounted for 28% of the total energy intake and 5.7 servings on average per day. In the unadjusted model, 15 circulating proteins had a significant association with UPF consumption. After adjustment, only (FGF-19) was significantly associated with UPF consumption (β =  - 0.02[- 0.03; - 0.003]).</p><p><strong>Conclusion: </strong>UPF consumption was negatively associated with Fibroblast Growth Factor 19 (FGF-19) serum levels. When considering UPF sub-categories, no circulating proteins were associated with dairy products and dairy desserts. Of note, circulating proteins were differentially associated depending on the sub-category of UPF. Further studies are needed to better understand the link between UPF and inflammation.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"94"},"PeriodicalIF":4.1,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voluntary physical activity suppresses adipocyte hypertrophy through the activation of cGMP mediated pathway in a fructose-induced metabolic syndrome model in rat.","authors":"Pınar Tayfur, Orkide Palabiyik, Burcu Meric, Ebru Tastekin, Selma Arzu Vardar","doi":"10.1007/s00394-025-03613-0","DOIUrl":"10.1007/s00394-025-03613-0","url":null,"abstract":"<p><strong>Purpose: </strong>A high-fructose diet is supposed to induce the so-called metabolic syndrome, associated with increased fat deposition in adipose tissue. Physical exercise may counteract the induction of the metabolic syndrome. The present study aims to investigate the effect of voluntary physical activity (VPA) on cGMP-mediated lipolysis in retroperitoneal adipose tissue in a metabolic syndrome model induced in rats by a high-fructose diet.</p><p><strong>Methods: </strong>Male Sprague-Dawley rats in control and fructose (F) groups had free access to either plain drinking water or a solution of 20% D-fructose, combined with a standard diet for 8 wk. Rats in the fructose + activity (F + A) group performed voluntary physical activity with a running wheel. Blood pressure, serum glucose, lipids and natriuretic peptide levels were measured on the last day of the feeding period. In retroperitoneal adipose tissue, cGMP, hormone-sensitive lipase (HSL), perilipin-1, aquaglyceroporin levels, and adipocyte diameter were analyzed.</p><p><strong>Results: </strong>Systolic blood pressure, glucose, and triacylglycerol were higher in the F groups compared to the control. The C-type natriuretic peptide was higher in the F group compared to the control. The cGMP level in retroperitoneal adipose tissue was higher in the F + A group than F group. Higher HSL and perilipin-1 levels were observed in the F + A group compared to the F and control groups. Adipocyte diameter was lower in the F + A group compared to the F group.</p><p><strong>Conclusion: </strong>Regular physical exercise triggers lipolytic effects in adipose tissue through cGMP, HSL, and perilipin-1-mediated pathway in fructose-induced metabolic syndrome model in rats, preventing the increase in adipocyte diameter.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"91"},"PeriodicalIF":4.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron intake and iron status of Swedish adolescents with diets of varying climate impact.","authors":"Elinor Hallström, Josefin Edwall Löfvenborg, Lotta Moreaus, Agneta Sjöberg, Anna Winkvist, Anna Karin Lindroos","doi":"10.1007/s00394-024-03572-y","DOIUrl":"10.1007/s00394-024-03572-y","url":null,"abstract":"<p><strong>Purpose: </strong>The risk of inadequate micronutrient intake is a concern of low-climate impact diets. This study analyzes the prevalence of iron deficiency (ID) among adolescents with varying dietary climate impact, with special reference to different types and dietary sources of iron.</p><p><strong>Methods: </strong>Data on dietary intake (n = 3099) and plasma ferritin (n = 1030) were from Riksmaten Adolescents 2016-2017 survey of Swedish girls and boys aged 11-18 years. Dietary climate impact was estimated with life cycle assessment data. Linear and logistic regression models assessed associations between dietary climate impact, intakes of iron and food groups, and ID.</p><p><strong>Results: </strong>Higher total iron and heme, but not non-heme, iron intake, was linearly associated with higher dietary climate impact. Compared to girls, boys had higher climate impact and low prevalence of ID. Girls in the highest climate impact quartile had 56% lower odds of ID (OR 0.44, 95% CI 0.24-0.81) compared to the lowest quartile, whereas no association was found in boys. Lower intake of red meat and heme iron was associated with ID in girls, while higher intake of dairy was associated with ID in boys. Menstruating girls and adolescents born outside of Sweden were identified risk groups for ID.</p><p><strong>Conclusions: </strong>Girls with a more climate-friendly diet and lower intake of red meat/heme iron may be at higher risk of ID compared to girls with higher dietary climate impact. These results highlight the importance of considering risk groups of ID, such as menstruating girls, in the transition to more plant-based diets with lower climate impact.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"93"},"PeriodicalIF":4.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11829901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal obesity, age and infant sex influence the profiles of amino acids, energetic metabolites, sugars, and fatty acids in human milk.","authors":"Imelda Cecilia Zarzoza-Mendoza, Emmanuel Cervantes-Monroy, Cristian Emmanuel Luna-Guzmán, José Carlos Páez-Franco, Hilda Sánchez-Vidal, Judith Villa-Morales, Alfonso Méndez-Tenorio, Fairt Vladimir Carmona-Sierra, Maricela Rodriguez-Cruz","doi":"10.1007/s00394-025-03601-4","DOIUrl":"10.1007/s00394-025-03601-4","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate whether maternal nutritional status, maternal age, mode of delivery, and the infant's sex influence the profiles of amino acids, energetic metabolites, sugars, and fatty acids and as well as the metabolic pathways in mature human milk human milk (HM).</p><p><strong>Methods: </strong>This was a cross-sectional, prospective, and observational study. HM samples from normal weight (NW, n = 60), overweight (OW, n = 35), and obese (OB, n = 14) women were analyzed using a non-targeted GC-MS method to identify the metabolome. Data obtained were analyzed with Metaboanalyst software (v. 5.0) and SPSS (v.25.0).</p><p><strong>Results: </strong>OB women HM contains a higher proportion of amino acids such as leucine, lysine, tyrosine, and aspartic acid, energy metabolites such as lactic and succinic acid, and sugars and derivatives such as fucose, rhamnose, and gluconic acid (p < 0.05) compared with normal weight women HM. HM from women > 25 years of age contains a lower proportion of lauric acid and a higher proportion of leucine and tyrosine (p < 0.05) than ≤ 25 years women HM. Also, HM intended for female infants has a higher leucine and gluconic acid content. The main altered metabolic pathways in OB women HM correspond to amino acids and energetic metabolism.</p><p><strong>Conclusion: </strong>OB women HM provides more amino acids, energetic molecules, and sugars. Increased maternal weight, BMI, and body fat mass predispose to more leucine and aspartic acid in HM. Maternal age influences lauric acid, leucin, and tyrosine levels, while the infant's sex influences leucine and gluconic acid levels in HM. The impact of obese women's HM metabolome on the offspring's physiology needs to be explored.</p><p><strong>Trial registration: </strong>R-2021-785-096.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"92"},"PeriodicalIF":4.1,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between nutrient patterns and odds of depressive symptomatology: a population-based cohort of older adults followed during 15-y.","authors":"Jeanne Bardinet, Camille Pouchieu, Virginie Chuy, Bénédicte Merle, Hermine Pellay, Sophie Lefèvre-Arbogast, Catherine Helmer, David Gaudout, Cécilia Samieri, Cécile Delcourt, Audrey Cougnard-Grégoire, Catherine Féart","doi":"10.1007/s00394-025-03597-x","DOIUrl":"10.1007/s00394-025-03597-x","url":null,"abstract":"<p><strong>Purpose: </strong>Nutrition, as a modifiable exposure, seems relevant to prevent depression. Several nutrients have been associated with a lower risk of depression in older adults, but longitudinal studies examining nutrient combinations are lacking. Therefore, we investigated the association between a posteriori nutrient patterns and the odds of depressive symptomatology (DS) in older adults over time.</p><p><strong>Methods: </strong>The sample included participants from the French Three-City cohort, a prospective population-based study focusing on adults ≥ 65 years. Nutrient intakes were assessed using a 24-hour recall in 2001 and Principal Component Analysis based on 40 nutrients, was performed to identify nutrient patterns. DS was assessed at each visit (up to eight visits until 2018) and defined by a Center for Epidemiologic Studies-Depression score ≥ 16 and/or antidepressant medication. Random effect logistic regression was performed to examine the association between nutrient patterns and DS over time controlled for potential confounding variables.</p><p><strong>Results: </strong>The study sample comprised 1,063 individuals (mean age 75.6y +/- 4.8) and 39.3% experienced DS at least once during a median follow-up of 11.5 years. Among 4 identified nutrient patterns, the first pattern characterised by high intake of magnesium, hydroxybenzaldehydes, stilbenes, dihydroflavonols, vitamin B6, lignans, tyrosols, folates, vitamins B3, B5, B1 and proanthocyanidins, was significantly associated with lower odds of DS over time (OR + 1 point = 0.85, 95% CI=[0.75;0.96]).</p><p><strong>Conclusions: </strong>In this large sample of older adults, a mixed nutrient pattern was associated with lower odds of DS over time, offering valuable insights into nutrient potential role in mental health among older adults.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"88"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between erythrocyte polyunsaturated fatty acids and gestational diabetes mellitus in Chinese pregnant women.","authors":"Nu Tang, Yannan He, Shamshad Karatela, Jinjing Zhong, Xiaoling Zeng, Qinggui Lu, Feng Zhao, Li Cai","doi":"10.1007/s00394-025-03603-2","DOIUrl":"10.1007/s00394-025-03603-2","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the associations of erythrocyte polyunsaturated fatty acids (PUFAs) with the risk of gestational diabetes mellitus (GDM) in pregnant women.</p><p><strong>Methods: </strong>A total of 951 women in mid-pregnancy (20-28 weeks of gestation) were recruited during 2017-2018. Erythrocyte PUFAs were measured by gas chromatography and expressed as a percentage of total fatty acids. A 75 g oral glucose tolerance test was used for GDM diagnosis. Logistic regression and restricted cubic spline models were conducted.</p><p><strong>Results: </strong>Among the 951 pregnant women, 180 were diagnosed with GDM (18.93%). For n-3 PUFAs, each standard deviation (SD) increase in α-linolenic acid (ALA) and docosapentaenoic acid (DPA) was associated with multivariable-adjusted odds ratios (ORs) of 0.789 (95% CI: 0.649, 0.961; P = 0.018) and 0.782 (95% CI: 0.638, 0.957; P = 0.017), respectively. However, the associations became marginally significant after post hoc false-discovery rate (FDR) correction (both P_FDR=0.065). A significant nonlinear association was observed for ALA and GDM risk (P_{- nonlinearity}=0.001). For n-6 PUFAs, γ-linolenic acid (GLA) was significantly associated with a 46.0% higher risk of GDM [OR (95%CI): 1.460 (1.195, 1.785), P_FDR=0.003) per SD increase], with a significant non-linear relationship (P_{- nonlinearity}=0.031). Arachidonic acid (AA) showed a borderline significant association with lower GDM risk after FDR correction [OR (95%CI): 0.736 (0.568, 0.953), P = 0.020, P_FDR=0.065].</p><p><strong>Conclusion: </strong>Erythrocyte GLA was significantly associated with an increased risk of GDM in pregnant women. Furthermore, we observed for the first time significant non-linear associations of erythrocyte ALA and GLA with GDM risk.</p><p><strong>Clinical trial registry number: </strong>NCT03023293, 2019-01-11.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"87"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postprandial plasma amino acid and appetite responses to a low protein breakfast supplemented with whey or pea protein in middle-to-older aged adults.","authors":"Marie Korzepa, Ryan N Marshall, Lucy M Rogers, Archie E Belfield, Jonathan I Quinlan, Yijia Huang, Ari Gritsas, Tyler A Churchward-Venne, Elisa I Glover, Luc J C van Loon, Gareth A Wallis, Leigh Breen","doi":"10.1007/s00394-025-03605-0","DOIUrl":"10.1007/s00394-025-03605-0","url":null,"abstract":"<p><p>The addition of low-dose protein to low protein-containing meals in middle-to-older aged adults may promote greater postprandial plasma aminoacidemia and mitigate declines in muscle health but may be dependent on the source and quality of protein consumed. This single-blind randomised study investigated postprandial plasma aminoacidemia and appetite regulatory responses to a typical lower protein-containing (∼0.07 g·kg body mass[BM]^-1) mixed breakfast supplemented with ∼0.13 g·kg BM^- 1 of whey protein concentrate (MB + WPC) or pea protein isolate (MB + PPI) in middle-to-older aged adults. Venous blood samples were collected whilst fasted and over a 180-min postprandial period to determine plasma amino acid and appetite hormone concentrations. Perceived appetite ratings were measured using Visual Analogue Scales. Plasma total amino acids and essential amino acids increased over time (both P < 0.05) with no between-group differences or overall availability over 180 min (incremental area under the curve (iAUC)). Plasma leucine concentrations increased over time (both P < 0.05) with greater peak concentrations (P = 0.032) and iAUC (P = 0.012) in MB + WPC compared with MB + PPI. Plasma total-ghrelin and total-GLP-1 concentrations and perceived ratings of hunger, fullness, and satiety were transiently altered following MB + WPC and MB + PPI (P < 0.05 for all), with no differences between groups. In middle-to-older aged adults, co-ingesting a small bolus of whey protein alongside a typical lower protein-containing breakfast elicits greater plasma leucinemia than co-ingestion of pea protein, with no differential impact on appetite regulation. Whether the addition of low-dose whey protein to typical meals of middle-to-older aged adults can enhance muscle anabolism without adversely affecting appetite remains to be determined.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"86"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based dietary patterns, genetic risk, proteome, and lung cancer risk: a large prospective cohort study.","authors":"Wenmin Zhu, Ziwei Shi, Xiaolong Yan, Zhiqun Lei, Qi Wang, Lin Lei, Sheng Wei","doi":"10.1007/s00394-025-03606-z","DOIUrl":"10.1007/s00394-025-03606-z","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to examine the associations between plant-based dietary patterns, genetic risk, proteins, and lung cancer risk.</p><p><strong>Methods: </strong>189,541 participants of the UK Biobank were included. The Cox proportional hazards models and restricted cubic splines were performed to assess the associations between overall plant-based diet index(PDI), healthy PDI (hPDI), and unhealthy PDI (uPDI) and lung cancer risk. Polygenic risk score (PRS) was constructed to assess its joint effect with PDIs on lung cancer risk. Mediation analysis was conducted to examine which proteins mediated the associations of PDIs with incident lung cancer.</p><p><strong>Results: </strong>Higher PDI was significantly correlated with reduced lung cancer risk(HR:0.90, 95% CI: 0.85-0.96, per SD). An elevated uPDI showed a significant correlation with an increased lung cancer risk(HR:1.08, 95% CI: 1.01-1.15, per SD). Individuals with a combination of high PRS and low PDI (HR: 2.09 [95% CI: 1.48-2.95]) or high uPDI (HR: 1.86 [95% CI: 1.36-2.53]) exhibited a notably higher lung cancer risk compared to those with low PRS and a high PDI or low uPDI. 42 proteins mediated the effect of PDI on lung cancer risk, and the association between uPDI with lung cancer was mediated by 117 proteins. The number of proteins displaying pathway enrichment within the cytokine-cytokine receptor interaction was the highest of the proteins mediated the effect of associations of PDI and uPDI with lung cancer risk.</p><p><strong>Conclusion: </strong>A higher PDI correlated with reduced lung cancer risk, while a higher uPDI correlated with an elevated lung cancer risk. Low PDI jointing with high genetic risk increased lung cancer risk. Proteins enriched in cytokine-cytokine receptor interaction may mediate the association between plant-based dietary patterns with lung cancer risk.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"89"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary patterns, nutrients, and risk of expiratory airflow limitation in children and adolescents.","authors":"Yijing Bao, Qing Chang, Han Zhang, Huiyuan Ding, Jing Gao, Chuyang Zhang, Baofeng Chi, Yang Xia, Yuhong Zhao, Hehua Zhang","doi":"10.1007/s00394-025-03604-1","DOIUrl":"10.1007/s00394-025-03604-1","url":null,"abstract":"<p><strong>Background: </strong>Increasing global pediatric respiratory diseases require understanding modifiable factors affecting lung function. We explored the association between dietary patterns, nutrients and the risk of expiratory airflow limitation (EAL) in children and adolescents.</p><p><strong>Methods: </strong>Dietary intake was collected using a validated food frequency questionnaire (FFQ) with 110 food items. Factor analysis was employed to determine dietary patterns. Pulmonary function was measured using a medical-grade pulmonary function analyzer. EAL was defined as the ratio of Forced Expiratory Volume in one second to Forced Vital Capacity (FEV₁/FVC) < 0.8.</p><p><strong>Results: </strong>A total of 611 EAL cases occurred in 3,204 participants, with a prevalence of 19.07%. Four primary dietary patterns were identified (animal, healthy, sweet, and plant foods), which explained 44% of the variance in food consumption. The plant foods pattern (fourth quartile vs. first quartile intake) was associated with a reduced risk of EAL (Odds Ratio [OR] = 0.71, 95% Confidence Interval [CI]: 0.53, 0.94; P_{for trend} < 0.02). Higher fruit consumption (high vs. low) in plant foods pattern was associated with lower EAL risk (OR = 0.79, 95% CI: 0.62, 0.99, P_{for trend} = 0.04). Every standard deviation increase in foods (Chinese sauerkraut, pickled foods) and nutrients (total dietary fiber, soluble dietary fiber, and pyridoxine) in plant foods was all positively associated with FEV₁ /FVC (all P < 0.05).</p><p><strong>Conclusions: </strong>Long-term intake of plant foods pattern enriched with dietary fiber and pyridoxine is promising for lung function protection in children and adolescents.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"85"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Curcumin plus piperine improve body composition in patients with inflammatory bowel disease: a randomized, double-blind, placebo-controlled clinical trial.","authors":"Amylly Sanuelly da Paz Martins, Orlando Roberto Pimentel de Araújo, Amanda da Silva Gomes, Fernanda Lívia Cavalcante Araujo, José Oliveira Júnior, Joice Kelly Gomes de Vasconcelos, José Israel Rodrigues Junior, Islany Thaissa Cerqueira, Manoel Álvaro de Freitas Lins Neto, Nassib Bezerra Bueno, Marília Oliveira Fonseca Goulart, Fabiana Andréa Moura","doi":"10.1007/s00394-025-03608-x","DOIUrl":"10.1007/s00394-025-03608-x","url":null,"abstract":"<p><p>This study evaluates the effects of oral supplementation of curcumin alone and curcumin plus piperine on body composition, phase angle, and functional capacity in patients with mild to moderate inflammatory bowel disease (IBD). Patients with a diagnosis of IBD, aged 18 years or older with intact kidney and liver function, were into three groups: placebo, curcumin (1000 mg/day), and curcumin plus piperine (1000 mg/day + 10 mg/day). Anthropometric markers, body composition, phase angle (via tetrapolar bioelectrical impedance analysis), and hand-grip strength were assessed before and after the 12-week supplementation period. Statistical analyses included Chi-square test (χ²) and generalized estimating equation (GEE) adjusted for age. Of the 58 patients who started the study, 51 completed it. Initially, obesity was prevalent according to BMI (43.1%) and body fat percentage (62.7%), while 86.3% exhibited muscle depletion based on fat-free mass (FFM). Post-intervention, the curcumin plus piperine group showed a significant reduction in muscle depletion, with improvements in FFM (χ², p = 0.019; GEE, p = 0.049) and phase angle (χ², p = 0.028) compared to the placebo group. In conclusion, our findings indicate that curcumin plus piperine significantly improves body composition by increasing muscle mass in patients with mild to moderate IBD, suggesting its potential as an adjuvant therapy. Trial registration: This trial was registered at ensaiosclinicos.gov.br as RBR89q4ydz on July 20, 2023. Website https://ensaiosclinicos.gov.br/ .</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 2","pages":"90"},"PeriodicalIF":4.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}