European Journal of Nutrition最新文献

{"title":"Correction: Weizmannia coagulans BC99 improved intestinal motility and chronic constipation through regulating gut microbiota: a randomized, double-blind, placebo-controlled trial.","authors":"Ying Wu, Yiqing Zhou, Qiuxia Fan, Yinyin Gao, Shuguang Fang, Yukun Sun, Shaobin Gu","doi":"10.1007/s00394-026-04070-z","DOIUrl":"https://doi.org/10.1007/s00394-026-04070-z","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Japanese dietary patterns to improve nutritional quality, reduce environmental impact under affordability constraints in younger and older adults from the nationwide MINNADE study.","authors":"Minami Sugimoto, Hitomi Okubo, Yasunori Kikuchi, Sander Biesbroek, Elisabeth H M Temme, Ryoko Katagiri","doi":"10.1007/s00394-026-04129-x","DOIUrl":"10.1007/s00394-026-04129-x","url":null,"abstract":"<p><strong>Purpose: </strong>To optimise diets that are more nutritious, have lower diet-related greenhouse gas emissions (GHGE) based on cradle-to-pre-retail impact, and remain affordable for Japanese adults of different age groups.</p><p><strong>Methods: </strong>Eight-day dietary records collected from younger (aged 18-49 years; 711 males and 734 females) and older (aged 50-74 years; 565 males and 605 females) Japanese adults were analysed. For each sex-age group, optimised diets were derived under three optimisation models using Data Envelopment Analysis: (i) MaxNRF: maximisation of diet quality score (Nutrient Rich Food Index [NRF] 9.3); (ii) MinGHGE: minimisation of GHGE; and (iii) OPT2G: combination of both objectives. All models included a monetary cost constraint (105% of observed). The proportions of participants having inadequate nutrient intakes, based on the Japanese Dietary Reference Intakes, were compared between observed diets and three optimised diets.</p><p><strong>Results: </strong>All optimised diets showed NRF9.3 scores 13.5-35.9% higher than those observed in all sex-age groups. GHGE decreased by 12.6-32.7% in the MinGHGE and OPT2G only. Differences between the optimised and observed diets in NRF9.3 score and GHGE were generally larger in younger than in older adults. All optimised diets showed lower or similar prevalences of inadequate nutrient intake compared with observed values. However, in younger males, optimised diets with MinGHGE had less favourable macronutrient distributions and higher inadequacies of vitamins A, C, and riboflavin than observed.</p><p><strong>Conclusion: </strong>Optimised diets showed better nutrient adequacy and lower GHGE across all sex-age groups, although specific nutrient shortfalls warrant attention when minimising GHGE in younger males.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin B₁₂ and folate intake and biomarker status among omnivore and vegetarian UK-dwelling women of childbearing age: pooled results from the National diet and nutrition surveys (2008-2019).","authors":"Ali Niklewicz, Luciana Hannibal, Kourosh R Ahmadi","doi":"10.1007/s00394-026-04117-1","DOIUrl":"10.1007/s00394-026-04117-1","url":null,"abstract":"<p><strong>Purpose: </strong>Vitamin B₁₂ is crucial for neurological function and maternal health, particularly during pregnancy and lactation. Women of childbearing age (WCBA) following unfortified plant-based diets are at increased risk of B₁₂ deficiency, which can adversely affect both maternal and infant health. This study analysed NDNS data (2008-2019) to: (1) compare vitamin B₁₂ intake and status, and folate intake and status, between omnivores and vegetarians; (2) examine the impact of supplementation; (3) explore predictors of B₁₂ biomarkers, including diet, supplementation, and age, and (4) assess the prevalence of vitamin B₁₂ insufficiency and deficiency in WCBA, per diet group.</p><p><strong>Methods: </strong>Data from 2,299 WCBA (2,204 omnivores and 89 vegetarians) in the National Diet and Nutrition Survey (2008-2019) were analysed. Survey-weighted means and 95% confidence intervals (CI) were calculated for nutrient intakes and biomarkers, and t-tests compared omnivores and vegetarians. Vitamin B₁₂ and folate intakes were assessed from food and supplements.</p><p><strong>Results: </strong>Mean dietary vitamin B₁₂ intake was significantly higher in omnivores (4.3 µg/day; 95% CI: 4.2-4.5) compared with vegetarians (2.9 µg/day; 95% CI: 2.5-3.3; p < 0.0001). Supplement use was more common among vegetarians (27%) compared with omnivores (10%). Mean dietary folate intake was higher in vegetarians (227.4 µg/day; 95% CI: 210.1-244.7) than omnivores (206.9 µg/day; 95% CI: 202.4-211.4; p = 0.025). Serum vitamin B₁₂ concentrations were higher in omnivores (271.3 pmol/L; 95% CI: 260.8-281.7) than vegetarians (231.0 pmol/L; 95% CI: 183.9-278.1; p = 0.1). Holotranscobalamin (HoloTC) was significantly lower in vegetarians (39.8 pmol/L; 95% CI: 33.1-46.5) compared with omnivores (63.1 pmol/L; 95% CI: 60.0-66.2; p < 0.001). Homocysteine concentrations were significantly higher in vegetarians (11.22 µmol/L; 95% CI: 9.21-13.23) than omnivores (8.49 µmol/L; 95% CI: 8.17-8.81; p = 0.009). Serum folate (22.1 vs. 18.1 nmol/L; p = 0.170) and red cell folate (583.4 vs. 528.9 nmol/L; p = 0.484) did not differ significantly between groups.</p><p><strong>Conclusions: </strong>Women of childbearing age following vegetarian diets had lower vitamin B₁₂ intakes and holotranscobalamin concentrations than omnivores, despite higher supplement use, with a substantial proportion falling below clinically significant thresholds for deficiency and insufficiency. In contrast, folate intake was higher among vegetarians. These findings highlight the need for targeted dietary guidance and supplementation to support adequate vitamin B₁₂ status in this population.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to the Nordic Nutrition Recommendations 2023 and incidence of type 2 diabetes: a Danish cohort study.","authors":"Mathilde M Nørgaard, Mathilde L Hansen, Anne B Mørch, Sissel H Juhl, Michael H Linnet, Trine Jørgensen, Patricia O Chocano-Bedoya, Daniel B Ibsen, Anja Olsen, Christina C Dahm","doi":"10.1007/s00394-026-04133-1","DOIUrl":"10.1007/s00394-026-04133-1","url":null,"abstract":"<p><strong>Purpose: </strong>Type 2 diabetes (T2D) is one of the most burdensome chronic diseases. Unhealthy dietary patterns are associated with greater risk of T2D, whereas plant-predominant and climate-friendly diets may be associated with lower risk of T2D. This study aimed to examine the association between adherence to the Nordic Nutrition Recommendations 2023 (NNR23) and risk of T2D in Danish middle-aged adults.</p><p><strong>Methods: </strong>This cohort study used data from the Danish Diet, Cancer and Health cohort. The study population was defined among participants with complete baseline data and no cancer at baseline, excluding those with T2D at baseline (n = 54,313). Diet was assessed using a validated semi-quantitative 192-items food frequency questionnaire. Adherence to NNR23 was measured using the Nordic Nutrition Recommendations 2023 Food-Based Diet Score (range 0-15 points). Incident cases of T2D were identified through linkage to the National Diabetes Register. The associations were analysed using Cox proportional hazards regression.</p><p><strong>Results: </strong>During a median follow-up time of 15.3 years, 7,143 participants developed T2D. Participants with moderate-high adherence (> 10-15 points) to NNR23 had a lower risk of T2D compared to those with low adherence (0-8 points) to NNR23 (HR: 0.63, 95% CI 0.57;0.70). Restricted cubic spline analysis showed a significant non-linear inverse association between adherence to NNR23 and T2D (p-value < 0.001 for non-linearity).</p><p><strong>Conclusion: </strong>Greater adherence to NNR23 was associated with lower risk of T2D, supporting the potential relevance of the NNR23 for T2D prevention.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Longitudinal association of dietary spermidine with hepatic function indexes and cardiometabolic traits in older adults with metabolic syndrome.","authors":"Andrés López-González, Esther Cuadrado-Soto, José M Ordovás, Miguel Ángel Martínez-González, Dolores Corella, Jordi Salas-Salvadó, Montserrat Fitó, J Alfredo Martínez, Ángel M Alonso-Gómez, Julia Wärnberg, Jesús Vioque, Dora Romaguera, José López-Miranda, Ramon Estruch, Francisco J Tinahones, José Lapetra, J Lluís Serra-Majem, Aurora Bueno-Cavanillas, Josep A Tur, Vicente Martín Sánchez, Xavier Pintó, Miguel Delgado-Rodríguez, Pilar Matía-Martín, Josep Vidal, Clotilde Vázquez, Montserrat Cofán, Javier Basterra-Gortari, Rebeca Fernandez-Carrion, Nancy Babio, Olga Castañer Niño, Diego Martínez-Urbistondo, Lucas Tojal-Sierra, Olga Fernández-Barceló, Carolina Ojeda-Belokon, Jadwiga Konieczna, Antonio Pablo Arenas-Larriva, Rosa Mª Casas, Bernal-López Mr, Sandra Martín-Peláez, Miguel Ruiz-Canela, Carolina Ortega-Azorin, Julio Plaza-Diaz, Karla Alejandra Pérez-Vega, María Ángeles Zulet, Itziar Salaverria-Lete, Sandra González-Palacios, Zenaida Vazquez-Ruiz, Josué A Pérez-Acosta, Víctor de la O, Lidia Daimiel","doi":"10.1007/s00394-026-04100-w","DOIUrl":"https://doi.org/10.1007/s00394-026-04100-w","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of serum metabolites associated with the EAT-Lancet planetary health diet, and their mediating role in weight status and weight changes in adults.","authors":"Tiina Suikki, Mirkka Maukonen, Aki S Havulinna, Rilla Tammi, Anne-Mari Halme, Pirkko Pussinen, Tuulia Kreetta Pietilä, Anne-Maria Pajari, Satu Männistö","doi":"10.1007/s00394-026-04115-3","DOIUrl":"10.1007/s00394-026-04115-3","url":null,"abstract":"<p><strong>Purpose: </strong>Better adherence to a healthy and sustainable diet has been associated with a lower body weight, but the underlying metabolic mechanisms remain unclear. We examined whether serum metabolites mediate this association.</p><p><strong>Methods: </strong>We used data from three Finnish population-based health examination studies (n = 9225, 54% of women, mean age of 54 years). Diet quality was assessed with a dietary score based on the Planetary Health Diet (PHD) adapted to Finnish food culture. Weight, height, waist circumference (WC), and body mass index were measured at baseline and follow-up, and their percentual changes over seven years were calculated. Serum metabolites (n = 158) were quantified using a high-throughput nuclear magnetic resonance (NMR) spectroscopy metabolomics platform (Nightingale Health Plc). The role of individual metabolites in the diet-anthropometry associations by sex were assessed by mediation analyses using multivariable linear regression. Analyses were replicated in an independent dataset of three additional Finnish studies (n = 10242).</p><p><strong>Results: </strong>Mediation analyses indicated that seven metabolites partly mediated diet-WC association in both men and women: short-chain fatty acid acetate (7.6/3.1%, respectively), degree of fatty acid unsaturation (26.0/23.1%), and several fatty acid-to-total fatty acid ratios (polyunsaturated (35.6/46.5%), docosahexaenoic (5.5/9.6%), omega-3 (4.0/9.8%), linoleic (31.4/49.9%), and saturated fatty acids (12.1/13.0%).</p><p><strong>Conclusion: </strong>The association between higher PHD adherence and a smaller WC was partly explained by several serum metabolites likely reflecting higher fiber intake and better fat quality of the PHD. These findings suggest that healthy and sustainable diets may contribute to weight management through favourable metabolic profiles.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma biomarkers of vitamin B6 homeostasis and the risk of stroke in individuals with type 2 diabetes: a nested case-control study.","authors":"Yi Ding, Xujia Lu, Yulong Fan, Ning Zhang, Zhengyuan Zhou, Yang Geng, Xiaohong Zhu, Yalong Pei, Xinmei Lu, Yan Borné, Shujun Gu, Chaofu Ke","doi":"10.1007/s00394-026-04126-0","DOIUrl":"10.1007/s00394-026-04126-0","url":null,"abstract":"<p><strong>Purpose: </strong>Vitamin B6 metabolism is implicated in chronic inflammation and insulin resistance, two important factors influencing stroke and type 2 diabetes, respectively. This study aimed to investigate the prospective associations of multiple plasma biomarkers of vitamin B6 homeostasis, i.e. 4-pyridoxic acid (PA), pyridoxal (PL), pyridoxal-5'-phosphate (PLP) and the ratio of PA:[PL+PLP] (PAr), with the risk of stroke in individuals with type 2 diabetes, and evaluate the predictive performance of these markers.</p><p><strong>Methods: </strong>This nested case-control study involved individuals with type 2 diabetes, 967 cases of incident stroke and 967 matched controls without stroke from a prospective Chinese cohort. Plasma levels of PA, PL and PLP were measured using a targeted metabolomics approach. The net reclassification index (NRI) was calculated to assess the predictive performance of PA, PL, PLP and PAr.</p><p><strong>Results: </strong>Compared with individuals with the lowest quartile of plasma PAr, the odds ratio (OR) and 95% CI was 2.915 (2.072-4.101) for the highest quartile. By contrast, the ORs (95% CIs) of the highest quartile versus the lowest were 0.577 (0.432-0.771) for PL, 0.652 (0.488-0.871) for PLP, and 1.232 (0.897-1.692) for PA, respectively. In addition, adding plasma levels of PAr, PL and PLP offered incremental reclassification ability for incident stroke beyond the conventional risk factors. The greatest reclassification ability improvement was observed for the combination of PAr, PL and PLP (NRI: 0.482, 95% CI: 0.395-0.568).</p><p><strong>Conclusions: </strong>Plasma levels of PAr, PL and PLP were significantly associated with the risk of incident stroke and provided incremental ability for the risk prediction of stroke in individuals with type 2 diabetes.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary intake of vitamins B1, B2, B3, and B6, and the risk of gastric cancer: pooled analyses within the Stomach cancer Pooling (Stop) project.","authors":"Giulia Collatuzzo, Claudio Pelucchi, Michele Sassano, Rossella Bonzi, Jesus Vioque, Sandra Gonzales-Palacios, Monireh Sadat Seyyedsalehi, Nuno Lunet, Samantha Morais, Gemma Castaño-Vinyals, Nerea Fernández Larrea-Baz, Monica Ferraroni, David Zaridze, Dmitry Maximovich, Guo-Pei Yu, Zuo-Feng Zhang, Lizbeth Lopez-Carrillo, Mary H Ward, Malaquias Lopez-Cervantes, Raul Ulises Hernandez-Ramirez, Charles S Rabkin, Reza Malekzadeh, Mohammadreza Pakseresht, Shoichiro Tsugane, Akihisa Hidaka, M Constanza Camargo, Maria Paula Curado, Francesca Bravi, Eva Negri, Carlo La Vecchia, Paolo Boffetta","doi":"10.1007/s00394-026-04112-6","DOIUrl":"10.1007/s00394-026-04112-6","url":null,"abstract":"<p><strong>Background: </strong>Disentangling the role of micronutrients in gastric cancer (GC) is challenging and results are inconsistent to date. We investigated associations of dietary intake of B vitamins with GC in a pooled analysis of international studies.</p><p><strong>Methods: </strong>We included orifinal data from 13 case-control studies of GC from the Stomach Cancer Pooling Project. Data were harmonized and study-specific quartiles of dietary intake of the B1 (thiamine), B2 (riboflavin), B3 (niacin) and B6 (pyridoxine) were created. We calculated odds ratios (OR) of associations between each B vitamin with GC and the corresponding 95% confidence intervals (CI) through logistic regression models adjusted for major risk factors. We then pooled study-specific ORs using random effect meta-analysis. Stratified analyses were conducted by sex, histologic type and anatomical site. Secondary analyses were further adjusted for Helicobacter pylori (Hp) infection, alcohol, meat and vegetables and fruit intake.</p><p><strong>Results: </strong>The study population included 5252 GC cases and 11,397 controls. We observed the following associations for one-quartile increase of dietary vitamin intake: B1, OR = 0.93 (95% CI = 0.88-0.97); B2, OR=0.97 (95% CI = 0.93-1.02); B3, OR = 0.95 (95% CI = 0.90-1.00); B6, OR = 0.86 (95% CI = 0.82-0.91); we observed an interaction between B1 and sex, with beneficil effect in men for the highest quartile of intake (p = 0.009). Main results were confirmed when further adjusting for Hp. When accounting for alcohol, meat and vegetables and fruit intakes, the associations were weakened or no more apparent. No heterogeneity was found between cardia and non-cardia GC; B2 was directly associated with diffuse but not intestinal GC (p = 0.03).</p><p><strong>Conclusions: </strong>Dietary intake of B1 and B6 vitamins might reduce the risk of GC. Studies with homogeneous method of micronutrients assessment and adjustments are needed to confirm our results.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Betaine supplementation modulates mitochondrial and redox-related adaptations in premenopausal women with overweight: a randomized controlled trial.","authors":"Emilia Zawieja, Monika Młodzik-Czyżewska, Agata Chmurzynska","doi":"10.1007/s00394-026-04131-3","DOIUrl":"10.1007/s00394-026-04131-3","url":null,"abstract":"<p><strong>Background & aims: </strong>The aim of this study was to investigate the effects of betaine supplementation on mitochondrial and redox-associated parameters in premenopausal women with overweight or obesity. We hypothesized that betaine enhances selected mitochondrial enzyme content and improves antioxidant defense.</p><p><strong>Methods: </strong>In this randomized controlled trial, premenopausal women with overweight or obesity were assigned to receive anhydrous betaine supplementation (3 g/d) or a placebo condition for eight weeks. Mitochondrial enzyme content was assessed in peripheral blood mononuclear cells (PBMCs), including citrate synthase (CS) and cytochrome c oxidase (COX). Redox-related parameters were evaluated in plasma; these included the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx), as well as oxidized glutathione (GSSG) concentration. Preintervention and postintervention measurements were compared between groups.</p><p><strong>Results: </strong>A significant treatment × time interaction was observed for CS concentration in PBMCs (p = 0.043). The pre-to-post change differed significantly between the betaine and placebo groups (between-group difference in change: 102.3 μg/mg protein, 95% CI 3.19 to 201.4), although the within-group pre-post changes were not statistically significant. No significant treatment × time interaction was observed for COX (p = 0.326). Plasma CAT activity showed a significant treatment × time interaction (p = 0.003, ηp² = 0.213) and increased significantly only in the betaine group. No significant effects were observed for SOD (p = 0.825), GPx (p = 0.359), or GSSG (p = 0.693).</p><p><strong>Conclusions: </strong>Betaine supplementation may selectively influence PBMC mitochondrial-associated parameters and circulating antioxidant enzyme activities in premenopausal women with overweight or obesity. The differential change in CS between the betaine and placebo groups and the increase in plasma CAT activity warrant further investigation, particularly to determine their physiological significance and underlying mechanisms.</p><p><strong>Trial registration: </strong>https://clinicaltrials.gov/study/NCT06344377.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645886/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Compliance with the Netherlands' vitamin D supplementation recommendation for three at-risk groups: young children, women over 50 years, and elderly.","authors":"M R Verbakel, M H de Jong, J Verkaik-Kloosterman","doi":"10.1007/s00394-026-04090-9","DOIUrl":"10.1007/s00394-026-04090-9","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}