European Journal of Nutrition最新文献

{"title":"High-fat and low-fat fermented milk and cheese intake, proteomic signatures, and risk of all-cause and cause-specific mortality.","authors":"Yufeng Du, Ruikun Bao, Shunming Zhang, Ulrika Ericson, Yan Borné, Lu Qi, Emily Sonestedt","doi":"10.1007/s00394-025-03815-6","DOIUrl":"https://doi.org/10.1007/s00394-025-03815-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the associations between the intake of high- and low-fat fermented dairy (cheese and fermented milk), their proteomic profiles, and mortality risk.</p><p><strong>Methods: </strong>This cohort study included 25,187 participants (mean age 57.7 years, 60.9% females). Fermented dairy intake was assessed by a modified diet history method. In a random subset of this cohort (n = 4359), we constructed proteomic signatures for fermented dairy intake using 136 candidate plasma proteins.</p><p><strong>Results: </strong>During 23.5 years of follow-up, 9742 participants died. High-fat cheese (> 20% fat) intake was inversely associated with risk of all-cause mortality (HR for an increment of 20 g/day, 0.97; 95% CI, 0.96-0.99, P < 0.001) and cardiovascular disease mortality (HR, 0.96; 95% CI, 0.93-0.99, P = 0.006). Low-fat cheese intake showed an inverse association with all-cause mortality (HR, 0.98; 95% CI, 0.96-1.00, P = 0.047). Low-fat fermented milk intake was inversely associated with all-cause mortality (HR for an increment of 250 g/day, 0.91; 95% CI, 0.85-0.97, P = 0.006), while high-fat fermented milk (> 2.5% fat) showed null association. A total of 42, 26, 0, and 39 proteins were identified for the signature of high-fat cheese, low-fat cheese, high-fat fermented milk, and low-fat fermented milk, respectively. Inverse associations with all-cause mortality were observed for all three signatures with identified proteins. The identified proteins were involved in biological pathways related to immune response and inflammation.</p><p><strong>Conclusion: </strong>Our study indicated that consuming high-fat cheese, low-fat cheese, and low-fat fermented milk was linked to survival benefits. Plasma proteins improve our understanding of the health effects of fermented dairy.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"297"},"PeriodicalIF":4.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Adherence to the EAT-Lancet diet and change in cognitive functioning in older adults.","authors":"Hanneke A H Wijnhoven, Marjolein Visser, Almar A L Kok, Margreet R Olthof","doi":"10.1007/s00394-025-03804-9","DOIUrl":"https://doi.org/10.1007/s00394-025-03804-9","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"299"},"PeriodicalIF":4.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary advanced glycation end products and the risk of depression and anxiety.","authors":"Yebing Zhang, Huanying He, Ruoqi Hao, Fangyuan Jiang, Xue Li, Zhengfeei Ma, Li-Qiang Qin, Guo-Chong Chen, Huan-Huan Yang, Zhongxiao Wan","doi":"10.1007/s00394-025-03818-3","DOIUrl":"https://doi.org/10.1007/s00394-025-03818-3","url":null,"abstract":"<p><strong>Purpose: </strong>Dietary advanced glycation end products (AGEs) might exert adverse effects on mental disorders. To explore whether elevated dietary AGEs intake is associated with increased risk of mental disorders, and whether this association might be affected by genetic risk and allostatic load (AL).</p><p><strong>Methods: </strong>A prospective cohort study, including a total of 112,989 participants, conducted at least two 24-h dietary assessments in the UK Biobank Study (2006-2010) and were followed up until 2021. Dietary AGEs, including Nε-(1-Carboxyethyl)-l-lysine (CEL), Nε-(carboxymethyl) lysine (CML), and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were estimated via averaged data from the multiple 24-h food assessments according to the ultra-performance LC-tandem MS based dietary AGEs database. Incident depression and anxiety, ascertained via hospital admission records and mental health questionnaires.</p><p><strong>Results: </strong>During an average follow-up period of 12.9 years, 5489 and 5163 participants developed depression and anxiety, respectively. When comparing high (Q5) quantiles with low quantiles (Q1&2) of dietary AGEs intake, HRs (95%CIs) of depression, anxiety, and mental disorders were 1.16 (1.07, 1.27), 1.11 (1.01, 1.22) and 1.14 (1.07, 1.22), respectively. High dietary CML and MG-H1 intake were also associated increased risk of depression, anxiety, and their co-occurrence. The positive associations between dietary AGEs intake and the risk of depression were more pronounced among participants with intermediate and high genetic risk (P-interaction < 0.001) and with high AL level (P-interaction = 0.019).</p><p><strong>Conclusions: </strong>Consuming high levels of dietary AGEs (including CML and MG-H1) was associated with an increased risk of depression and anxiety. This association may be affected by genetic risk and AL.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"296"},"PeriodicalIF":4.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Folate intake, tissue levels, and colorectal cancer deaths in a national cohort established before folic acid fortification.","authors":"Anunay Bhattacharya, Marian Tabi, Jingjing Yin, Logan Cowan, Jian Zhang","doi":"10.1007/s00394-025-03762-2","DOIUrl":"https://doi.org/10.1007/s00394-025-03762-2","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"295"},"PeriodicalIF":4.3,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Substituting animal protein foods with plant protein foods influences vitamin B12 and folate statuses in a multiethnic Asian population.","authors":"Yu Qi Lee, Airu Chia, Xueling Sim, Rob M van Dam, Mary F-F Chong","doi":"10.1007/s00394-025-03812-9","DOIUrl":"https://doi.org/10.1007/s00394-025-03812-9","url":null,"abstract":"<p><strong>Purpose: </strong>The influence of a shift from animal-based to plant-based diets on vitamin B12 and folate statuses in Asian populations remains unclear. We examined the associations between substituting animal protein foods with plant protein foods and vitamin B12 and folate statuses in an Asian population.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted using data collected from 993 Singapore residents (aged 21-75 years) from the Singapore Multi-Ethnic Cohort. Dietary intake was assessed using a validated food frequency questionnaire. Fasting blood samples were collected. Serum vitamin B12 and folate concentrations were determined by microbiological assay and deficiencies were defined by < 148 pmol/L and < 10 nmol/L respectively. Multivariable logistic and linear regression analyses were conducted to examine the associations.</p><p><strong>Results: </strong>Substituting white fish or oily fish with 30 g per day equivalent of various plant protein foods was associated with higher odds of vitamin B12 deficiency [odds ratio (OR) ranged from 1.62 to 1.85, 1.98 to 2.23 for white and oily fish respectively; p < 0.05]. Similarly, substituting a combination of meats (including red and white meat, processed meat and processed seafood) simultaneously with an equivalent portion of refined grains (30g per day) was associated with a higher odds of vitamin B12 deficiency (OR 1.12; p < 0.05). In contrast, substituting processed meat and processed seafood with an equivalent portion of vegetables or nuts and seeds was associated with higher folate serum levels (β: 1.19 and 2.50 respectively; p < 0.05).</p><p><strong>Conclusions: </strong>Total elimination of meats and replacing them with refined grains may pose a greater risk of vitamin B12 deficiency than reduction of individual meats. Dietary guidelines in Asia should encourage higher intakes of high quality, nutrient-dense plant-based foods and lesser red and processed meats to prevent vitamin B12 and folate deficiencies. Similarly, an emphasis on fish intake, especially oily fish, to prevent vitamin B12 deficiency in the Asian population is needed.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"294"},"PeriodicalIF":4.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative proteomic and metabolomic analysis reveals the mechanisms underlying ischemic stroke induced by vitamin B12 deficiency.","authors":"Li Zhou, Haiyun Wu, Jiani Wang, Yilin Wang, Yanli Cai, Yong Zhao, Yu Ren, Qin Yang","doi":"10.1007/s00394-025-03816-5","DOIUrl":"https://doi.org/10.1007/s00394-025-03816-5","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"293"},"PeriodicalIF":4.3,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The proportion of plant-based food consumption during midlife and cognitive health in later life in Australian women: data from the Women's Healthy Ageing Project (WHAP).","authors":"Phuong Le, Cassandra Szoeke, Kaitlin Day, Russell Conduit, Sharayah Carter, Catherine Itsiopoulos","doi":"10.1007/s00394-025-03786-8","DOIUrl":"10.1007/s00394-025-03786-8","url":null,"abstract":"<p><strong>Purpose: </strong>Plant-based food (PBF) is well-known for its benefits for physical health; however, its impacts on brain health are less well understood, especially in ageing women. This study aimed to examine the association between different proportions of midlife daily PBF intake and late-life cognitive health among ageing Australian women.</p><p><strong>Methods: </strong>This study used data of 186 women who had dietary assessment at baseline (1998, aged 52-63) and cognitive assessments at follow-up (2012, aged 66-77) from the Women's Healthy Ageing Project (WHAP). The cohort was divided into quartiles according to the proportions of PBF in their daily diet at baseline. Late-life cognitive function was assessed by Global cognitive composite score (GCCS)-a summary of z-scores of 13 cognitive tests of the Cogstate battery. Three regression models were conducted: unadjusted (N = 186), partially adjusted (age, education, energy intake; N = 186), and fully adjusted (age, education, energy intake, BMI, physical activity, smoking, APOE 4 allele status, N = 165).</p><p><strong>Results: </strong>In unadjusted and partially adjusted models (N = 186), women in the third quartile (Q3) (second highest consumption of PBF during midlife) had significantly higher GCCS in later life compared to those in the lowest quartile (Q1) (B = 0.39, 95% CI [0.13; 0.66]; p = 0.004 for the unadjusted model; B = 0.34; 95% CI [0.08; 0.61]; p = 0.012, for the partially adjusted model). However, this association was no longer significant in the fully adjusted model (N = 165) (B = 0.25; 95% CI [- 0.02; 0.51]; p = 0.07), where APOE 4 allele status emerged as a significant predictor (B = - 0.25, 95% CI [ - 0.45; - 0.04]; p = 0.02). This change may reflect the reduced statistical power due to smaller sample size and the confounding effect of the genetic risk factors. Among APOE 4 carriers, higher PBF quartiles (Q2-Q4) each predicted greater GCCS in unadjusted analyses; in the adjusted model, Q3 versus Q1 remained significant, but the overall model did not reach significance. Investigation into the change in PBF consumption from midlife to late-life revealed no association with late-life cognitive health.</p><p><strong>Conclusion: </strong>Midlife PBF consumption did not show a significant independent association with late-life cognitive health after fully adjustment for confounders in this cohort of older Australian women. However, these findings should be interpreted with caution as the small sample size and confounding factors might have affected the ability to detect a subtle effect of PBF on cognition. Future research is needed to explore this relationship in larger, more diverse samples and its complex interaction with genetic risk factors.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"292"},"PeriodicalIF":4.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotics improve functional performance in patients with osteoarthritis: a randomized placebo-controlled clinical trial.","authors":"Asima Karim, Haroon Ahmed Khan, Firdos Ahmad, Rizwan Qaisar","doi":"10.1007/s00394-025-03805-8","DOIUrl":"https://doi.org/10.1007/s00394-025-03805-8","url":null,"abstract":"<p><strong>Purpose: </strong>Osteoarthritis (OA), a progressive joint degeneration, significantly impairs people's ability to perform everyday tasks. Currently, there are no treatment options to cure OA.</p><p><strong>Objective: </strong>To explore the potential of probiotics to improve functional performance in OA patients.</p><p><strong>Trial design: </strong>This study follows a single-center, double-blinded, randomized, placebo-controlled clinical trial design.</p><p><strong>Method: </strong>Computer-based randomization assigned 60-75 years old 115 OA patients randomly into placebo (n = 55) and probiotics (n = 60) groups. The probiotic treatment was Vivomix 112 billion, one capsule daily to assess probiotic efficacy within a 16-week timeframe. The analysis included measurements of pain intensity with a visual analog scale, oxford knee score (OKS), knee flexion range of movement (ROM), short physical performance battery (SPPB), gait speed, handgrip strength (HGS), zonulin as a marker of intestinal permeability, c-reactive protein (CRP) as markers of inflammation and 8-isoprostanes for oxidative stress. Two measurements at baseline and after 16 weeks were recorded.</p><p><strong>Results: </strong>14 patients discontinued probiotic treatment, and six patients discontinued placebo intake, therefore, 95 patients, including placebo (n = 49) and probiotics (n = 46) groups, were analyzed. Probiotics significantly reduced plasma zonulin and pain intensity during walking, alongside notable improvements in OKS scores, ROM, gait speed, HGS, and SPPB scores compared to baseline in the probiotics group (all p < 0.05). The probiotic supplement significantly lowered CRP levels. Correlation analysis showed a robust association of % changes in plasma zonulin with OKS scores (r² = 0.294, p < 0.0001), SPPB total (r² = 0.233, p = 0.0007), and HGS (r² = 0.322, p < 0.0001).</p><p><strong>Conclusion: </strong>Multistrain probiotics enhances functional ability in OA patients; changes in zonulin suggest a possible link to intestinal permeability, though causality remains to be established.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"290"},"PeriodicalIF":4.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D, muscle strength and function in South Asian women aged ≥ 60 years living in the North of England: a cross-sectional observational study.","authors":"Sabeen Zahra, Fraser Wiggins, Bernard M Corfe, Elizabeth A Williams","doi":"10.1007/s00394-025-03787-7","DOIUrl":"10.1007/s00394-025-03787-7","url":null,"abstract":"<p><strong>Purpose: </strong>The importance of vitamin D is well established for bone health and there is some evidence that inadequate/deficient vitamin D status is associated with reduced skeletal muscle strength and physical function in older adults. Most of this evidence for the muscular effect has come from white population groups and the evidence base is sparse for other ethnic groups. This study investigates the relationship between vitamin D status, muscle strength and function in UK South Asian women aged ≥ 60 years.</p><p><strong>Methods: </strong>This cross-sectional study included 120 community-dwelling Indian and Pakistani women, aged ≥ 60 years living in the North of England. Circulating blood 25(OH)D concentration was assessed by HPLC-MS using finger prick blood samples; functional capacity was assessed using handgrip strength, single and repeated chair stands, timed up and go, and balance test. Regression analysis was used to analyse the relationships between vitamin D status and muscle strength and function.</p><p><strong>Results: </strong>The median (IQR) age of the women was 66 (64-73) years. Forty-seven percent of the women were vitamin D inadequate/deficient. Around forty-one percent of the women reported taking a daily vitamin D supplement, 86% of whom were vitamin D sufficient (≥ 50 nmol/L). In non-vitamin D supplement users 32% were vitamin D sufficient. Women with vitamin D sufficiency had significantly better single chair stand (p = 0.045), repeated chair stand (p = 0.01), and balance (p = 0.040) test than those with deficiency/inadequacy. No difference was observed in handgrip strength and timed up and go.</p><p><strong>Conclusion: </strong>In this group of South Asian women aged ≥ 60 years, vitamin D deficiency/inadequacy was common in those not taking vitamin D supplements. Inadequate/deficient vitamin D status was associated with poor performance of lower limb muscle function, but no association was found with handgrip strength and timed up and go. The associations between supplementation, vitamin D status and lower limb strength helps support a rationale for targeted supplementation in this population of older UK South Asian women.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"291"},"PeriodicalIF":4.3,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12511266/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between total, animal-based, and plant-based protein intake and cognitive decline in older adults.","authors":"Maud Peperkamp, Margreet R Olthof, Marjolein Visser, Hanneke A H Wijnhoven","doi":"10.1007/s00394-025-03810-x","DOIUrl":"10.1007/s00394-025-03810-x","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 7","pages":"288"},"PeriodicalIF":4.3,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12500841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}