European Journal of Nutrition最新文献

{"title":"Dietary glucosamine supplement use and lower surgery risk in individuals with inflammatory bowel disease: a prospective Cohort Study.","authors":"Jiawei Geng, Xuejie Chen, Sidan Wang, Lintao Dan, Qijia Gong, Jie Chen, Xiaoyan Wang, Xiaocang Cao, Zhongyan Du","doi":"10.1007/s00394-025-03705-x","DOIUrl":"https://doi.org/10.1007/s00394-025-03705-x","url":null,"abstract":"<p><strong>Purpose: </strong>We aim to evaluate the association between the use of glucosamine, a widely used dietary supplement, and the risk of IBD-related surgery in a prospective cohort study.</p><p><strong>Methods: </strong>We leveraged data from 6059 individuals with IBD from the UK Biobank. Habitual use, frequency of use, and the dose of glucosamine were evaluated using self-reported records, multiple rounds of dietary recall, and prescription information from primary care data, respectively. IBD-related surgery was identified through inpatient data. Cox proportional-hazard model and logistic regression model were applied to examine the associations.</p><p><strong>Results: </strong>During a mean follow-up of 12.2 years, we documented 684 incident IBD-related surgery events. Compared with non-users, habitual glucosamine users presented (66.6 vs 97.1 cases/10,000 person-years, HR 0.73, 95% CI 0.58-0.92, P = 0.009) lowered risk of IBD-related surgery, decreased risk in Crohn's disease (80.6 vs 131.0 cases/10,000 person-years, HR 0.60, 95% CI 0.41-0.89, P = 0.011), while it was not significant in ulcerative colitis (61.1 vs 79.5 cases/10,000 person-years, HR 0.88, 95% CI 0.65-1.18, P = 0.386). The risks of IBD-related surgery were also lower among occasional users (HR 0.34, 95% CI 0.15-0.77, P = 0.010) and constant users (HR 0.48, 95% CI 0.25-0.90, P = 0.022) than non-users. For those using prescribed glucosamine, a higher prescription dose was associated with a lower risk of related surgery (OR 0.15, 95% CI 0.02-0.86, P = 0.034).</p><p><strong>Conclusion: </strong>Use of glucosamine, as a safe dietary supplement, is associated with a lower risk of IBD-related surgery, which would be a promising strategy in IBD management.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"191"},"PeriodicalIF":4.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of recognition of genetic information related to BMI on changes in physical activity, dietary intake, and blood cholesterol level: a randomized controlled trial.","authors":"Ga Young Lee, Junghak Lee, Jeong-Han Kim, Kyong-Mee Chung, Sung Nim Han","doi":"10.1007/s00394-025-03713-x","DOIUrl":"10.1007/s00394-025-03713-x","url":null,"abstract":"<p><strong>Purpose: </strong>Genes associated with body mass index (BMI), including FTO rs9939609,MC4R rs17782313, and BDNF rs6265, may influence BMI and regulate energy metabolism. While previous studies have explored health-related behavior changes, few have investigated both biochemical and behavior changes resulting from perceived genetic risk. This study investigated whether recognizing BMI-related genes affects health-related behaviors and alters blood metabolite levels.</p><p><strong>Methods: </strong>Normal and overweight adults aged 25-35 years (n = 100) were randomly assigned to an intervention group (n = 65) informed about BMI-related genetic information (FTO rs9939609, MC4R rs17782313, BDNF rs6265) and an uninformed group (n = 35, CON). The intervention group was further divided into Intervention-high risk (IHR, n = 36) and intervention-low risk (ILR, n = 29) subgroups. Dietary intake and physical activity (PA) were assessed using a 3-day dietary record and the IPAQ-short form. Blood metabolites were analyzed through multivariate analyses to identify significant differences among the groups, with measurements taken at baseline, 3 months, and 6 months.</p><p><strong>Results: </strong>The IHR group exhibited increased dietary fat and fast foods intake, along with enhanced vigorous and moderate PA. Six metabolites were selected as biomarkers that were distinguishable among groups, and the relative serum cholesterol levels significantly decreased in the IHR group at 3 months.</p><p><strong>Conclusion: </strong>These results demonstrate that recognizing the BMI-associated genetic risk resulted in a short-term increase in PA but did not improve dietary intake. Increased PA was significantly associated with reduced cholesterol concentration, suggesting the clinical importance of physical activity in the genetically at-risk group.</p><p><strong>Clinical trial and study registration: </strong>This study was reviewed and approved by the Seoul National University Institutional Review Board (IRB #1901/001-004) and registered on the Clinical Research Information Service (CRIS), KCT0004650 ( https://cris.nih.go.kr/cris/search/detailSearch.do /14091, 2020/01/28).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"190"},"PeriodicalIF":4.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary manganese intake is positively associated with metabolic dysfunction-associated steatotic liver disease: a multicohort study.","authors":"Hao Yu, Di Wang, Yan Yan, Lirui Jiao, Jinjin Zhang, Yeqing Gu, Shunming Zhang, Qing Zhang, Li Liu, Ge Meng, Hongmei Wu, Xuehui Wu, Dandan Zhu, Liyuan Fu, Yinxiao Chen, Dongli Wang, Yaxiao Wang, Hao Geng, Shaomei Sun, Xing Wang, Qiyu Jia, Kun Song, Yunliang Zheng, Ming Yu, Yu-Ming Chen, Kaijun Niu","doi":"10.1007/s00394-025-03708-8","DOIUrl":"https://doi.org/10.1007/s00394-025-03708-8","url":null,"abstract":"<p><strong>Background and aims: </strong>Manganese (Mn) is an essential nutrient that plays a crucial role in maintaining normal physiological functions of the human body. However, overexposure to Mn often leads to adverse health outcomes and contributes to the development of a variety of diseases. Several studies have explored the relationship between dietary Mn and metabolic dysfunction-associated steatotic liver disease (MASLD) risk. Two UK Biobank (UKB)-based studies suggested that Mn, as a key nutrient, may be associated with a reduced risk of MASLD. Another study found an association between the dietary antioxidant index and the onset of non-alcoholic fatty liver disease (NAFLD), highlighting the importance of nutritional factors (including Mn) in liver health. However, the relationship between dietary Mn intake and MASLD in the Chinese population remains unexplored, and further research is needed to elucidate its underlying mechanisms.</p><p><strong>Methods: </strong>This prospective multi-cohort study had 1,137 adults from the Guangzhou Nutrition and Health Study (GNHS) cohort and 17,649 people from the Tianjin Chronic Low-grade Systemic Inflammation and Health (TCLSIH) cohort. We measured dietary intake using a validated and standardized food frequency questionnaire. Annual abdominal ultrasound was used to diagnose new-onset MASLD. We used multivariable Cox regression models to assess the relationship between dietary Mn intake and the risk of MASLD.</p><p><strong>Results: </strong>In the TCLSIH cohort, 3640 MASLD cases were observed with a follow-up time of 60,190 person-years. After taking into account possible confounding factors, the multivariable HRs (95% CIs) for MASLD across the quartiles of dietary Mn intake in males were 1.00 (reference), 1.08 (0.96-1.21), 1.12 (0.99-1.26), and 1.16 (1.02-1.31), with a P for trend = 0.02; for females, the HRs (95% CIs) for MASLD across the quartiles of dietary Mn intake were 1.00, 1.11 (0.95-1.31), 1.08 (0.91-1.28), and 0.97 (0.81-1.16), with a P for trend = 0.58. After adjustment for proteins, lipids, and carbohydrates, the HRs (95% CIs) for MASLD across the quartiles of dietary Mn intake in males were 1.00 (reference), 1.11 (0.97-1.26), 1.14 (1.00-1.31), and 1.16 (1.00-1.34), with a P for trend = 0.045. For females, the HRs (95% CIs) for MASLD across the quartiles of dietary Mn intake were 1.00 (reference), 1.08 (0.91-1.30), 1.06 (0.88-1.27), and 0.93 (0.76-1.13), with a P for trend = 0.39. In the GNHS cohort, 624 MASLD cases were observed with a follow-up time of 6454 person-years. After adjusting for relevant confounders, the HRs (95% CIs) for males comparing T3 versus T1 of dietary Mn intake were 1.04 (0.65-1.60); the HRs (95% CIs) for females comparing T3 versus T1 of dietary Mn intake were 1.00 (0.78-1.29).</p><p><strong>Conclusion: </strong>In males, higher dietary Mn intake is associated with a higher incidence of MASLD.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"188"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility and relative validity of a quantitative food frequency questionnaire developed for adults in the coastal area of southeast China.","authors":"Qingling Su, Jiamin Gong, Yifeng Chen, Xiaoyun Li, Xiaoyin Huang, Weihong Qiu, Henggui Chen, Shanshan Du, Weimin Ye","doi":"10.1007/s00394-025-03704-y","DOIUrl":"https://doi.org/10.1007/s00394-025-03704-y","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the reproducibility and validity of a 93-item food frequency questionnaire (FFQ) designed to assess usual dietary habits over the past year among adults in the southeast coastal region of China.</p><p><strong>Methods: </strong>Qualified dietary data of 477 subjects (75.26% female, mean age = 59.7 years) were collected via two FFQs over approximately 15 months, alongside four 4-day 24-hour dietary recalls (24 h-DRs) at average intervals of four months. The analysis included 25 general nutrients, 14 particular nutrients and 12 food groups. Wilcoxon signed-rank test, correlation coefficients, cross-classification with weighted kappa statistic and Bland-Altman plots were used for comparison.</p><p><strong>Results: </strong>For reproducibility, the Spearman, Pearson, and intraclass correlation coefficients between two FFQs ranged from 0.24 to 0.53, 0.21 to 0.53 and 0.19 to 0.53, respectively. After adjusting for energy intake, most coefficients either decreased or remained unchanged. The rates of agreement in classifying subjects in the same or adjacent quartile fell between 62% and 84% for both FFQs. Regarding validity, the crude Spearman, energy-adjusted and de-attenuated Pearson correlation coefficients between FFQs and 24 h-DRs ranged from 0.17 to 0.59, 0.12 to 0.54, and 0.13 to 0.57, respectively. Over 58% of subjects were classified into the same and adjacent categories by both methods. Weighted kappa statistic and Bland-Altman plots demonstrated acceptable concordance.</p><p><strong>Conclusion: </strong>The FFQ developed for adults in the specific coastal region of China, aiming to be used in a population-based cohort study, demonstrates acceptable reproducibility and validity to measure the dietary intakes of certain nutrients and foods.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"186"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized controlled cross-over trial of differences in acute effects on serum metabolites from isocaloric meals based on red meat, fatty fish, or soy protein.","authors":"Helen M Lindqvist, Erik Hulander, Linnea Bärebring, Inger Gjertsson, Anna Winkvist","doi":"10.1007/s00394-025-03710-0","DOIUrl":"10.1007/s00394-025-03710-0","url":null,"abstract":"<p><strong>Purpose: </strong>Reducing red meat intake in the Western diet is beneficial for health and the environment. However, red meat is nutrient-rich, so understanding the impact of substituting it with other protein sources such as fish or plant-based proteins is essential, especially for vulnerable groups like the elderly and those with chronic diseases. The purpose of this study was to study the postprandial response in serum metabolites in women with Rheumatoid Arthritis (RA) after intake of red meat, fatty fish, and soy protein.</p><p><strong>Methods: </strong>Women with RA (n = 24) consumed isocaloric meals that included burgers made from either red meat, fatty fish, or soy protein in a crossover design. Blood samples were taken in fasting state before the meal (0 h) and at intervals up to 5 h after eating. Nuclear Magnetic Resonance (NMR) analysis quantified serum metabolites, and multivariate models and univariate statistics were applied to compare postprandial metabolite changes across protein sources.</p><p><strong>Results: </strong>Postprandial metabolite patterns varied significantly by protein type. The fatty fish meal led to a faster and higher increase in metabolites, including creatinine, isoleucine, valine, and trimethylamine N-oxide, compared to red meat. Unidentified lipids also differed. However, metabolite patterns after soy protein were similar to those after red meat.</p><p><strong>Conclusion: </strong>This postprandial crossover trial found that intake of fatty fish lead to a quicker and more pronounced increase in key blood concentrations of metabolites compared to red meat. However, metabolite profiles in serum based on NMR-analysis were similar after intake of soy protein compared to red meat.</p><p><strong>Trial registration: </strong>The PIRA (Postprandial Inflammation in Rheumatoid Arthritis) trial is Registered at Clinicaltrials.gov (NCT04247009).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"187"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucoregulatory status modulates acute cognitive effects of repeated low-glycaemic snack consumption in older adults: a decentralized randomized controlled trial.","authors":"Litali Mohapatra, Rafael Cabral, Mansi Bhatnagar, Puck Wee Chan, Maisie Ng, Xin Yu Chua, Chun Siong Soon, Stijn Massar, Maria de Iorio, Jeroen A J Schmitt","doi":"10.1007/s00394-025-03712-y","DOIUrl":"https://doi.org/10.1007/s00394-025-03712-y","url":null,"abstract":"<p><strong>Purpose: </strong>This study examined the effects of differential postprandial glucose responses on cognition in healthy older adults in a real-life setting. We hypothesised that consumption of a lower GI snack would have favourable effects on cognitive functioning and that this effect would be more pronounced in individuals with better glucoregulatory status.</p><p><strong>Methods: </strong>Twenty-eight healthy adults, aged 50-65 years, underwent two intervention periods of three consecutive test days, consuming either a low-GI snack or a control snack twice a day in a cross-over design. Cognitive performance and self-reported cognitive ability, mood, and appetite were measured six times on each of the six test days using a mobile application. Continuous glucose monitoring (CGM) occurred throughout the study. Glycated haemoglobin (HbA1c) and fasting glucose levels were taken as markers of glucoregulatory status.</p><p><strong>Results: </strong>Consumption of the low-GI snack led to blunted post-prandial glucose responses but did not affect cognitive functioning. Significant interactions between the snack effect and glucoregulatory status were observed for Spatial Memory (p < 0.01), Symbol Search (p < 0.05), Composite Cognition score (p < 0.05), and a trend for subjective cognitive ability (p = 0.07), indicating poorer effects of the low GI snack in subjects with poorer glucoregulation. Fluctuations in blood glucose parameters did not mediate the cognitive effects of the snacks or cognitive function fluctuations throughout the test days.</p><p><strong>Conclusion: </strong>We demonstrated that poorer glucoregulatory status negatively affected the cognitive responses to a low-GI snack intervention. This interaction between glucoregulatory status and treatment response was detectable in non-diabetic subjects with normal to mildly compromised glucose regulation.</p><p><strong>Trial registration: </strong>NCT05801731, 24-03-2023.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"189"},"PeriodicalIF":4.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin-mineral supplements and cognition among adults aged 65 and older: multiple cross-sectional population-based studies.","authors":"Daniela Marques, Martin Preisig, Pedro Marques-Vidal","doi":"10.1007/s00394-025-03700-2","DOIUrl":"10.1007/s00394-025-03700-2","url":null,"abstract":"<p><strong>Purpose: </strong>Many people consume vitamin-mineral supplements (VMS), to prevent cognitive decline or enhance cognition. We assessed the association between VMS intake and cognition.</p><p><strong>Methods: </strong>Data from three follow-ups of the population-based CoLaus|PsyColaus cohort. Participants aged ≥ 65 years were included and categorized as VMS consumers or non-consumers. Cognitive tests included the Mini-Mental State Examination (MMSE), Stroop colour test, the CERAD praxis items, lexical and semantic fluency tasks, and the Grober and Buschke episodic memory test.</p><p><strong>Results: </strong>There were 925 (64.5% women), 836 (41.1%), and 516 (29.4%) participants from the first (2009-2013), second (2014-2018) and third (2019-2021) follow-ups, respectively. After multivariable adjustment, no significant differences were found between VMS non-consumers and consumers regarding almost all cognitive tests. The multivariable-adjusted mean ± SEM of MMSE for VMS non-consumers vs. consumers were 29.27 ± 0.06 vs. 29.28 ± 0.09, 29.21 ± 0.06 vs. 29.28 ± 0.07 and 29.32 ± 0.08 vs. 29.21 ± 0.09 for the first, second, and third follow-ups, all p > 0.05. The exceptions were Stroop C, where non-consumers had a statistically better but clinically irrelevant performance than consumers at the third follow-up: effect size 0.30 (0.01; 0.58) p = 0.042 and the Grober and Buschke test in the first follow-up, where VMS consumers scored better than non-consumers in free recall: 9.11 ± 0.15 vs. 8.55 ± 0.10 (p = 0.003), with opposite findings in cued recall: 5.99 ± 0.14 vs. 6.48 ± 0.09 (p = 0.004).</p><p><strong>Conclusion: </strong>We found no clinically significant association between VMS use and cognitive performance.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"184"},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between antioxidant vitamin intake and mental health in Swedish adolescents: a cross-sectional study.","authors":"Martina Pensa, Karin Kjellenberg, Emerald Heiland, Örjan Ekblom, Gisela Nyberg, Björg Helgadóttir","doi":"10.1007/s00394-025-03701-1","DOIUrl":"10.1007/s00394-025-03701-1","url":null,"abstract":"<p><strong>Purpose: </strong>Mental health problems are increasingly prevalent during adolescence. Nutritional factors, particularly antioxidants, are of interest due to their potential to reduce oxidative stress and inflammation linked to mental health issues. However, the relationship between dietary antioxidants and adolescent mental health remains unclear. This study aimed to investigate this association in Swedish adolescents and explore potential gender differences.</p><p><strong>Methods: </strong>Cross-sectional data were gathered among Swedish boys and girls aged 13-14 years (n = 1139). Participants reported their dietary intake using a detailed web-based method and mental health outcomes, including anxiety, psychosomatic symptoms, and health-related quality of life (HRQoL) using self-report scales. Multiple linear regression analysis, adjusted for confounders, was used to investigate the associations between mental health outcomes and tertiles of dietary intake of vitamin C, E and β-carotene.</p><p><strong>Results: </strong>Adolescents in the highest tertile of β-carotene intake reported lower anxiety (β=-1.23, 95% CI=-2.34, -0.12), fewer psychosomatic symptoms (β=-0.91, 95% CI=-1.69, -0.13), and better HRQoL (β = 0.89, 95% CI = 0.11, 1.68). Similarly, higher vitamin C intake was associated with fewer psychosomatic problems (β=-1.00, 95% CI=-1.79, -0.21). Vitamin E intake showed no associations. Significant gender interactions were observed on the multiplicative scale analysis and limited to the middle tertiles of β-carotene and vitamin C for anxiety and psychosomatic symptoms, respectively.</p><p><strong>Conclusion: </strong>Our findings underscore the potential role of dietary antioxidants, particularly β-carotene and vitamin C, in adolescent mental health. Further research including diverse populations and employing prospective designs could deepen the understanding and inform public health interventions.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 5","pages":"185"},"PeriodicalIF":4.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to consider more than just calcium? The impact on protein, riboflavin, vitamin B12 and iodine intake of replacing cows' milk with plant-based milk-like drinks-an Australian usual intake dietary modelling study.","authors":"Anita S Lawrence, Daniel Russo-Batterham, Kim Doyle, Edoardo Tescari","doi":"10.1007/s00394-025-03697-8","DOIUrl":"10.1007/s00394-025-03697-8","url":null,"abstract":"<p><strong>Purpose: </strong>Most plant-based milk-like (PBML) drinks sold in Australia are not fortified with riboflavin, vitamin B12 or iodine. Reduced dairy intake is often recommended for planetary health and the 2013 Australian Dietary Guidelines advise that PBML drinks are a suitable replacement for cows' milk if calcium fortified. We investigated the likely population-wide impacts on riboflavin, vitamin B12, iodine and protein usual intakes of replacement of cows' milk with PBML drinks.</p><p><strong>Methods: </strong>We used computer simulation modelling of data from the 2011-12 National Nutrition and Physical Activity Survey (n = 11,925 persons aged 2 + years). Cows' milk was replaced with PBML drinks and the likely impacts on usual intakes of riboflavin, vitamin B12, iodine and protein were assessed across eight age groups (National Cancer Institute method). A usual intake below the Estimated Average Requirement (EAR) was defined as inadequate.</p><p><strong>Results: </strong>Replacement of cows' milk with unfortified PBML drinks would likely lead to an increased proportion of older women (71 + years) with an inadequate riboflavin intake (from 20 to 31%), of older men and females aged 14 + years with an inadequate vitamin B12 intake (from < 1 to 9%, from 5-8 to 11-17%, respectively), and an increased proportion of males and females (2 + years) with an inadequate iodine intake (from 2 to 5%, from 8 to 16%, respectively). Effects on protein adequacy were more minor except for older adults.</p><p><strong>Conclusion: </strong>Replacement of cows' milk with most types of Australian PBML drinks has the potential to adversely impact riboflavin, vitamin B12, iodine and protein intake adequacy within the Australian population and future recommendations should consider all population groups and a range of nutrients, not just calcium.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 4","pages":"182"},"PeriodicalIF":4.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12102094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of fish oil supplements and plasma fatty acids with lung function decline.","authors":"Zhilin Zheng, Qi Wu, Yue Fang, Hongkun Di, Ming Zhang, Xuejie Ding, Quanhong Liu, Zhaomin Chen, Shiyu Yang, Bin Wang, Min Zhou, Dongming Wang, Jixuan Ma, Qinmei Ke, Weihong Chen, Xiang Cheng, Zhilei Shan, Yanjun Guo","doi":"10.1007/s00394-025-03702-0","DOIUrl":"https://doi.org/10.1007/s00394-025-03702-0","url":null,"abstract":"<p><strong>Purpose: </strong>Fish oil supplements and plasma fatty acid levels were reported to be associated with lung function. We aimed to investigate the association of fish oil supplements and plasma fatty acids with lung function.</p><p><strong>Methods: </strong>We included 248,133 participants with complete data on relative index of plasma fatty acids from the UK Biobank. Linear regression models were used to investigate associations of fish oil supplements and plasma fatty acids with pulmonary function. Mediation analysis was performed to identify the potential mediating role of plasma fatty acid. All analyses were multivariable-adjusted.</p><p><strong>Results: </strong>Higher lung function was observed in fish oil users (14.59 ml for FEV1 and 17.92 ml for FVC). We found that each 1-unit increment of plasma PUFA, omega-3, omega-6, DHA, LA, and PUFA/MUFA were positively associated with lung function (6.74 ml, 6.15 ml, 5.81 ml, 22.23 ml, 7.44 ml, and 66.67 ml for FEV1, respectively; 9.04 ml, 3.39 ml 8.63 ml, 25.51 ml, 9.53 ml, and 93.02 ml for FVC, respectively), while SFA and MUFA were inversely associated with lung function (-8.74 ml and -8.19 ml for FEV1, respectively; -10.44 ml and -11.83 ml for FVC, respectively). Omega-6/omega-3 only showed a negative association with FEV1 (-1.17 ml). Mediation analysis suggested that plasma fatty acids partly mediated the associations between fish oil supplements intake and lung function, mainly DHA (34.70% and 31.50% for FEV1 and FVC, respectively).</p><p><strong>Conclusions: </strong>We provided evidence that fish oil supplements and plasma fatty acids were both associated with lung function parameters, and the positive association between fish oil intake and lung function was mainly mediated by DHA.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 4","pages":"183"},"PeriodicalIF":4.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}