European Journal of Nutrition最新文献

{"title":"Carbohydrate-to-fat ratio is positively associated with comprehensive frailty across protein-intake levels in older adults.","authors":"Hinako Nanri, Tsukasa Yoshida, Eiichi Yoshimura, Jun Kunisawa, Hiroyuki Fujita, Misaka Kimura, Yosuke Yamada","doi":"10.1007/s00394-026-04099-0","DOIUrl":"10.1007/s00394-026-04099-0","url":null,"abstract":"<p><strong>Purpose: </strong>Diet influences frailty, and protein intake has been a prime focus of prevention. However, frailty remains prevalent, even among older adults with relatively high protein intake, suggesting the influence of remaining energy distribution between carbohydrates and fats. We investigated the association between the carbohydrate-to-fat energy ratio (CFr) and comprehensive frailty in older Japanese adults and whether this association differed by protein intake.</p><p><strong>Methods: </strong>Cross-sectional baseline data from 5679 community-dwelling adults aged ≥ 65 years in the Kyoto-Kameoka Study were analyzed. Diet was assessed using a validated 46-item food-frequency questionnaire. Percent energy from carbohydrates, fats, and protein was calculated. CFr was defined as the ratio of percent energy from carbohydrates to that from fat. Frailty was defined as a Kihon Checklist score ≥ 7. Multivariable logistic regression estimated odds ratios (ORs) and 95% confidence intervals (CIs) for frailty across CFr quartiles, adjusting for sociodemographic, lifestyle, and health-related factors. Restricted cubic splines assessed dose-response associations overall and within sex-specific tertiles of protein intake.</p><p><strong>Results: </strong>Among the 5679 participants, 1705 (30.0%) had comprehensive frailty. Compared with the lowest CFr quartile, the adjusted ORs were 1.12 (95% CI, 0.92-1.36) for Q2, 1.44 (1.18-1.76) for Q3, and 1.92 (1.55-2.38) for Q4 (P for trend < 0.001). Positive associations were also observed across sex-specific protein-intake tertiles, with no evidence of effect modification by protein intake.</p><p><strong>Conclusion: </strong>A higher CFr is associated with a higher prevalence of comprehensive frailty in older Japanese adults, with broadly similar associations across protein-intake levels.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An overview of international reference values for vitamin E intake - similarities and differences in derivation.","authors":"Christina Breidenassel, Volker Böhm, Ibrahim Elmadfa, Maren Podszun, Karl-Heinz Wagner, Stefan Lorkowski","doi":"10.1007/s00394-026-04121-5","DOIUrl":"10.1007/s00394-026-04121-5","url":null,"abstract":"<p><strong>Purpose: </strong>The scientific knowledge for the essential fat-soluble vitamin E (VitE) remains inconclusive. There is still a lack of valid status parameters and deficiency symptoms for insufficient intake. Therefore, the derivation of a dietary reference value (DRV) for VitE is challenging and differs between the different organizations and countries. The aim of the current paper is to provide an overview of selected international DRVs and discuss the different derivation procedures.</p><p><strong>Methods: </strong>DRVs from sixteen countries and international organizations were retrieved, compared and evaluated.</p><p><strong>Results: </strong>The DRVs are inconsistent in the absolute value as well as the employed concept of derivation. Due to the uncertainty of the available data some organizations did not specify a DRV. Others used plasma cut off levels or the required amount for the protection of polyunsaturated fatty acids against oxidation. Many DRVs are based on population intake data and given as adequate intake. But this approach may overestimate the VitE needs.</p><p><strong>Conclusion: </strong>In conclusion, due to missing symptoms and markers of insufficient supply, the compensation of daily losses with the consideration of the bioavailability appears to be a good basis for deriving a DRV for VitE intake. A balanced and plant-based diet (without supplements) appears to be sufficient for an adequate VitE supply.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of postprandial changes in the lipidome of capillary plasma and dry blood spots of young women.","authors":"Stephany G Duarte, Carlos M Donado-Pestana, Larissa Rodrigues, Marcos Yoshinaga, Adriano B Chaves-Filho, Sayuri Miyamoto, Jarlei Fiamoncini","doi":"10.1007/s00394-026-04119-z","DOIUrl":"10.1007/s00394-026-04119-z","url":null,"abstract":"<p><strong>Purpose: </strong>The postprandial period provides a dynamic window to assess metabolic function, as nutrient intake elicits measurable shifts in metabolism, that can be used to assess health status. Traditional venipuncture, though standard for blood sampling, poses practical limitations for postprandial studies that require repeated collections. This study evaluated the feasibility of using dry blood spots (DBS) as a minimally invasive alternative for monitoring postprandial lipemia, which can vary significantly after the intake of high-fat meals.</p><p><strong>Methods: </strong>Ten young women (26.1 ± 4.5 years) participated in a controlled clinical trial designed to evaluate lipidomic responses to a standardized, energy-dense meal using both DBS and capillary plasma samples. An analytical method based on ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC-ESI-TOFMS) was employed for the quantitative profiling of lipid species.</p><p><strong>Results: </strong>The postprandial lipidome derived from DBS and plasma samples exhibited high concordance, with triglycerides (TG) and free fatty acids (FFA) standing out among 18 identified lipid classes as the most responsive to food intake in both matrices. Postprandial TG concentrations increased by 64% in plasma and 34% in DBS, while FFAs decreased by 36% and 14%, respectively. In addition, DBS-specific postprandial lipidomic signatures were observed, including alterations in the levels of glycerophospholipids and sphingolipids, along with a peculiar kinetic pattern of phosphatidylethanolamines levels following food intake.</p><p><strong>Conclusion: </strong>These findings highlight the suitability of DBS for capturing postprandial lipidomic changes in circulation, particularly in TG and FFA levels, and support its utility as a practical and scalable tool for metabolic phenotyping in nutritional research, population studies, and clinical monitoring.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental impact ramifications of replacing added sugar with non-nutritive sweeteners in a high-calorie Dutch diet: the SWEET project.","authors":"J Suckling, A C Grasso, E Koukouna, J M Groen, M Tyszler, S Morse, M Raats, S B Astley, J C G Halford, J A Harrold, A Raben, J Scholten, C Scott, R Murphy","doi":"10.1007/s00394-026-04127-z","DOIUrl":"10.1007/s00394-026-04127-z","url":null,"abstract":"<p><strong>Purpose: </strong>Growing concern about excess added sugar intake and associated adverse health effects has increased interest in non-nutritive sweeteners (NNS) as low-calorie alternatives that preserve sweetness. Previous studies focus on health effects of replacing added sugar, or environmental impacts of NNS alone. However, none evaluate the environmental impact ramifications of replacing added sugar with NNS in a whole dietary setting. This study addresses that gap.</p><p><strong>Methods: </strong>The baseline diet reflected an average diet of Dutch adults consuming > 2200 kcal/day (mean 2866 kcal/day). Added sugar (54 g/day), identified from recipe data, was replaced with steviol glycosides and a bulking agent (e.g., sorbitol) to create the NNS diet. Both diets were linked to life cycle assessment data and optimized separately for nutritional adequacy and the 2023 IPCC 1.5 °C target of 2.04 kgCO₂-eq/day.</p><p><strong>Results: </strong>Both diets had equivalent global warming potential (GWP, 4.18 kgCO₂-eq/day), but the NNS diet used 11% more water (compared to 1.19 × 10^- 1 m³/day of baseline diet). When optimized for nutritional adequacy, GWP for both diets reduced 13%, and water consumption increased 3-9%. When optimized for nutrient adequacy and emissions targets, water consumption decreased by 11-15% across both diets.</p><p><strong>Conclusion: </strong>These results highlight an opportunity for policymakers and consumers to focus on the health benefits of added sugar reduction rather than environmental trade-offs. Both dietary patterns can be further improved regarding nutritional and climate goals, suggesting that balanced, low-emission diets are attainable across different sweetness strategies. The study identifies methodological challenges in modeling realistic dietary substitutions and provides guidance for future research.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-based diet quality and risk of giant cell arteritis and polymyalgia rheumatica: findings from the E3N prospective cohort study.","authors":"Lucas Pacoureau, François Barde, Chloé Marques, Amandine Gelot, Emmanuelle Correia, Francesca Romana Mancini, Yann Nguyen, Raphaèle Seror","doi":"10.1007/s00394-026-04109-1","DOIUrl":"10.1007/s00394-026-04109-1","url":null,"abstract":"<p><strong>Objectives: </strong>Environmental determinants of giant cell arteritis (GCA) and polymyalgia rheumatica (PMR) remain poorly understood. We investigated whether adherence to plant-based dietary patterns (overall (PDI), healthful (hPDI), and unhealthful (uPDI)) is associated with incident GCA and PMR in a large prospective cohort.</p><p><strong>Methods: </strong>The E3N study follows 98,995 French women since 1990. Dietary intake was assessed in 1993 using a validated food frequency questionnaire. PDI, hPDI, and uPDI were constructed following the approach of Satija et al. Incident GCA and PMR cases were identified and validated through repeated questionnaires and medication reimbursement data. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards regression models adjusted for age, energy intake, and key confounders.</p><p><strong>Results: </strong>Among 60,187 eligible women, 602 incident cases were identified over a median of 17.6 years between dietary assessment and disease onset (142 GCA, 373 PMR, 87 undifferentiated). No association was observed between any plant-based diet index and overall GCA/PMR risk nor PMR risk separately. Higher adherence to the hPDI was inversely associated with GCA risk (HR tertile 3 vs. 1: 0.62 [0.39-0.97]; p-trend = 0.04). A non-linear pattern was observed for the overall PDI (HR tertile 2 vs. 1: 0.65 [0.43-0.98]). No association was found for the uPDI.</p><p><strong>Conclusion: </strong>Adherence to a healthful plant-based diet was inversely associated with GCA risk but not PMR, suggesting disease-specific environmental pathways. These findings provide the first prospective evidence linking dietary quality to GCA risk, supporting further investigation of dietary exposures in inflammatory rheumatic diseases.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher adherence to a Nordic diet is associated with reduced risk of mild depressive symptoms: a population-based analysis.","authors":"Johanna Mylläri, Jyrki K Virtanen, Niina E Kaartinen, Tuija Jääskeläinen, Outi Nuutinen, Pilvikki Absetz, Satu Männistö, Anu Ruusunen, Timo Partonen","doi":"10.1007/s00394-026-04107-3","DOIUrl":"10.1007/s00394-026-04107-3","url":null,"abstract":"<p><strong>Purpose: </strong>Although the Mediterranean diet has been widely studied in relation to depression, less is known about the associations between other diets, such as the Nordic Diet, and depressive symptoms and clinical depression. The aim was to examine whether adherence to a Nordic diet (assessed with the modified Nordic Diet Index, mNDI) is associated with depressive symptoms and clinical depression in the Finnish Health 2000-2011 survey.</p><p><strong>Methods: </strong>The cross-sectional data included 4697 adults, while the prospective data included 1788 participants for depressive symptoms and 1862 for depressive disorders. Depressive symptoms were assessed in 2000 using a composite variable derived from validated questionnaires, and in 2011 using the Beck Depression Inventory-13 (BDI-13). Clinical diagnoses were based on the Munich-Composite International Diagnostic Interview (M-CIDI) or self-report.</p><p><strong>Results: </strong>At baseline, 1746 participants (37.2%) reported elevated depressive symptoms. Higher mNDI (indicating better adherence) was associated with 25.0% lower multivariable-adjusted odds of depressive symptoms (Q4 vs. Q1; 95% CI 8.6-38.5%, p-trend = 0.013). In the prospective analyses, higher mNDI was associated with lower odds of elevated depressive symptoms (BDI-13 cut-off scores 1 and 5), but these associations attenuated after full adjustment. No association was observed at the BDI-13 cut-off 9 (all p-values ≥ 0.303). Adherence to a Nordic diet was not associated with clinical depression.</p><p><strong>Conclusion: </strong>Higher adherence to a Nordic diet was associated with fewer depressive symptoms and a reduced risk of elevated depressive symptoms, but not with clinical depression, possibly due to the limited number of cases diagnosed via M-CIDI or reported by participants (n = 82).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reference intervals of urinary clearance and excretion of uric acid (RICE-U) in Japan.","authors":"Kazuhiro Itoh, Hiroshi Tsutani, Nozomi Otsuki, Yasuhiko Mitsuke, Takanori Ueda, Shigemi Hosogaya, Toshiko Seki, Ayumi Shintani, Masao Tomita, Mitsuru Munemasa, Atsumasa Komori, Shinya Otsuka, Tatsuji Komatsu, Ryuichiro Anan, Morio Sawamura, Takuyuki Ise, Kiyoki Kitagawa, Kazuya Yonezawa, Itaru Funakawa, Masato Hasegawa, Shinichi Shimosaka, Hidenori Ibata, Masatoshi Shimizu, Yasushi Tanimoto, Masahiro Suzuki, Hiroaki Ito, Kazuya Shirasaki, Yoshiaki Oda, Tomomasa Tsuboi, Tsutomu Shinohara, Michihisa Jogasaki, Nozomu Kamei, Shusaku Maeda, Keita Uehara, Kazuki Honda, Hitoshi Inoue","doi":"10.1007/s00394-026-04110-8","DOIUrl":"10.1007/s00394-026-04110-8","url":null,"abstract":"<p><strong>Purpose: </strong>To establish reference intervals for indices of renal uric acid excretion efficiency and amount using 24-h, 60-min, and spot urine measurements, and to assess relationships among these methods in healthy Japanese adults.</p><p><strong>Methods: </strong>This multicenter prospective observational study included 445 reference individuals (214 men and 231 women; age, 20-65 years) recruited from 26 National Hospital Organization institutions. Reference intervals were estimated separately by sex using the non-parametric central 95% range (2.5th-97.5th percentiles). Associations between spot urine-derived and timed-urine indices were assessed using Spearman rank correlations.</p><p><strong>Results: </strong>Reference intervals for 24-h Cua were 3.1-11.5 mL/min in men and 4.4-14.6 mL/min in women, and those for 60-min Cua were 4.7-15.4 and 5.1-17.9 mL/min, respectively. BSA-standardized Eua reference intervals were 280-827 mg/day/1.73 m² in men and 263-812 mg/day/1.73 m² in women for 24-h collection, and 16.4-42.9 and 12.4-36.3 mg/h/1.73 m², respectively, for 60-min collection. Spot urine reference intervals were 3.0-9.7% in men and 3.2-12.4% in women for FEua, 0.19-0.50 and 0.14-0.43 mg/dL for EuGF, 3.6-12.3 and 4.0-16.1 mL/min/1.73 m² for eCua, and 336-937 and 254-806 mg/day/1.73 m² for eEua. Spot eCua correlated with 24-h Cua (ρ=0.627), spot FEua with 24-h FEua (ρ=0.736), and eEua with 24-h Eua (ρ=0.430); all P<0.001.</p><p><strong>Conclusion: </strong>This study provides comprehensive reference intervals for renal uric acid handling under standardized preanalytical conditions in healthy Japanese adults. Spot urine-derived indices showed significant associations with timed-urine measurements, particularly for clearance-related indices, and may provide practical complementary measures when timed urine collection is difficult.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-supplementation of zinc and probiotic on oxidative stress markers and sleep quality index in irritable bowel syndrome patients: a double-blind randomized controlled trial.","authors":"Mahsa Rezazadegan, Parvane Saneei, Maryam Soheilipour, Niloufar Rezazadegan, Reza Amani","doi":"10.1007/s00394-026-04130-4","DOIUrl":"10.1007/s00394-026-04130-4","url":null,"abstract":"<p><strong>Background: </strong>Irritable bowel syndrome (IBS) is a functional gastrointestinal (GI) disorder that is related to impaired gut microbiota (GM) composition and sleep disorders. Zinc and probiotics play key roles in gut barrier integrity maintenance and microbiota modulation. Therefore, the current study investigated the effect of zinc and probiotic co-supplementation on oxidative stress biomarkers and sleep quality in IBS patients.</p><p><strong>Methods: </strong>In this parallel, randomized clinical trial, 84 participants with IBS were randomly allocated to three groups and received: 1- a zinc gluconate tablet (20 mg elemental zinc) and a probiotic placebo; 2- a zinc gluconate tablet and a probiotic capsule; 3- two placebos for a period of 90 days. After 10-12 h overnight fasting, serum zinc, total antioxidant capacity (TAC), total oxidant status (TOS), malondialdehyde (MDA) levels, superoxide dismutase (SOD) activity as well as sleep quality were assessed by validated methods. Oxidative stress index (OSI) was also calculated.</p><p><strong>Results: </strong>Supplementation with zinc, without or with probiotic, enhanced serum zinc (mean change: 6.36 ± 0.80 and 13.03 ± 3.82, vs. -1.76 ± 1.82 µg/dL; p = 0.008) compared to placebo. Zinc supplement alone and in combination with probiotics significantly decreased serum TOS level (mean change: - 1.47 ± 0.38 and - 1.67 ± 0.60, respectively, p = 0.001) and OSI (mean change: -1.70 ± 0.28 and - 2.05 ± 0.63, respectively, p = 0.004) in comparison to the placebo group. However, no significant between-group effects were observed for serum MDA, TAC, SOD activity, and sleep quality.</p><p><strong>Conclusion: </strong>Zinc supplementation, alone or with probiotics, may improve serum zinc and TOS levels, and OSI in IBS patients. Future studies are warranted to confirm these findings and their clinical relevance.</p><p><strong>Trial registration: </strong>This study was registered on January 29, 2024, at the Iranian Registry of Clinical Trials ( https://www.irct.ir ) (registration number: IRCT20180818040827N5).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 8","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Closing the dietary fibre gap - developing a novel dietary fibre screening tool (SCREEN-IT) for the UK population: validity, reproducibility and usability insights.","authors":"Victoria Norton, Julie A Lovegrove, Michelle Weech, Eve F A Kelly, Stella Lignou","doi":"10.1007/s00394-026-04071-y","DOIUrl":"10.1007/s00394-026-04071-y","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149059225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating HPLC-determined vitamins A, E and B-complex (B₁, B₂, B₃, B₆, B₉) with population intake estimates: insights from Cuba's inaugural Total Diet Study.","authors":"Yenisleidys Fernández-Guerrero, Ociel Muñoz-Fariña, Olga García, María Cristina Ravanal, Luisbel González","doi":"10.1007/s00394-026-04120-6","DOIUrl":"10.1007/s00394-026-04120-6","url":null,"abstract":"<p><p>Purpose To quantify seven dietary vitamins and estimate their mean daily intakes and major food sources among Cuban adults through the country's first Total Diet Study.Methods Standardized 24-hour dietary recalls were collected from 450 adults across Western, Central, and Eastern Cuba between October 2020 and March 2021. Foods were classified into 16 groups, prepared as consumed, homogenized, and analyzed using validated high-performance liquid chromatography with ultraviolet and fluorescence detection. Vitamin concentrations were combined with mean food consumption to estimate daily intakes, which were compared with nutritional reference values.Results Estimated mean daily intakes were 831 µg retinol equivalents for vitamin A, 6.8 mg α-tocopherol equivalents for vitamin E, 1.6 mg thiamine, 1.8 mg riboflavin, 32 mg niacin equivalents, 2.7 mg pyridoxine, and 220 µg dietary folate equivalents. Mean intakes of thiamine, riboflavin, niacin, and pyridoxine exceeded the adult reference values used in the study, whereas vitamin E and folate reached 68% and 55% of their respective benchmarks. Dairy products, vegetables, fruits, and fish were major vitamin A sources; meats and legumes contributed substantially to thiamine intake, and vegetables and legumes were the leading folate sources.Conclusion The reported mean intake estimates identify vitamin E and folate as priorities for dietary improvement in Cuba. Promoting nutrient-rich foods and evaluating selective fortification could help address these gaps. These population mean estimates do not establish individual nutritional adequacy or deficiency prevalence; further assessment of usual intake distributions and nutritional biomarkers is warranted.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"65 7","pages":""},"PeriodicalIF":4.5,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149037200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}