European Journal of Nutrition最新文献

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Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-25 DOI: 10.1007/s00394-025-03588-y
Evgeny Pokushalov, A Ponomarenko, C Garcia, L Kasimova, I Pak, E Shrainer, A Romanova, D Kudlay, M Johnson, R Miller
{"title":"Assessing the combined effects of Black Cohosh, Soy Isoflavones, and SDG Lignans on menopausal symptoms: a randomized, double-blind, placebo-controlled clinical trial.","authors":"Evgeny Pokushalov, A Ponomarenko, C Garcia, L Kasimova, I Pak, E Shrainer, A Romanova, D Kudlay, M Johnson, R Miller","doi":"10.1007/s00394-025-03588-y","DOIUrl":"https://doi.org/10.1007/s00394-025-03588-y","url":null,"abstract":"<p><strong>Objective: </strong>This randomized, double-blind, parallel-group clinical trial aimed to evaluate the efficacy of Black Cohosh, Soy Isoflavones, and SDG Lignans in alleviating menopausal symptoms compared to a placebo.</p><p><strong>Methods: </strong>Ninety-six postmenopausal women aged 45-60 years were enrolled. Participants were randomized to receive either the study supplements or a placebo for 90 days, with Menopause Rating Scale (MRS) scores collected at baseline and every 4 weeks to monitor symptom changes. Secondary outcomes assessed included hormonal variations and the incidence of adverse symptoms.</p><p><strong>Results: </strong>Of the initial cohort, 90 participants completed the study with high adherence. Significant improvements were observed in the treatment group across all MRS domains: somatic (- 54.3% difference, p < 0.01), psychological (- 54.3% difference, p < 0.01), urogenital (-37.3% difference, p < 0.01), and total score (- 48.0% difference, p < 0.01). Hormonal changes were modest yet statistically significant for FSH (- 6.7% difference, p < 0.01) and estradiol (12.6% difference, p < 0.01). Adverse events were minimal, transient, and did not require cessation of supplementation.</p><p><strong>Conclusion: </strong>Black Cohosh, Soy Isoflavones, and SDG Lignans significantly reduced menopausal symptoms with a favorable safety profile. These findings support the potential of this supplement combination as a therapeutic option for menopausal symptom management.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT06328348.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"138"},"PeriodicalIF":4.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Urinary excretion of low- and no-calorie sweeteners (LNCS) and associated food sources, as observed in the German cross-sectional KarMeN-study.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-24 DOI: 10.1007/s00394-025-03644-7
Ralf Krüger, Bernhard Watzl, Benedikt Merz
{"title":"Urinary excretion of low- and no-calorie sweeteners (LNCS) and associated food sources, as observed in the German cross-sectional KarMeN-study.","authors":"Ralf Krüger, Bernhard Watzl, Benedikt Merz","doi":"10.1007/s00394-025-03644-7","DOIUrl":"10.1007/s00394-025-03644-7","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to quantify urinary excretion of LNCS (Low- and No-Calorie Sweeteners) and to identify LNCS-associated food consumption in Germany, with special emphasis on exposure to combinations of different LNCS.</p><p><strong>Methods: </strong>UPLC-MS/MS was used to quantify LNCS metabolites in 24-hour urine samples of 301 participants from the cross-sectional KarMeN (Karlsruhe Metabolomics and Nutrition) study. Dietary data were assessed via 24 h recall. Spearman rank correlation analysis and multiple linear regression models were used to investigate food groups that contribute to LNCS exposure.</p><p><strong>Results: </strong>Based on the number of samples with quantifiable urinary concentrations and the absolute excretion within a day, cyclamate (88% of samples), saccharin (44%), acesulfame (35%), and aspartame (32%) were most commonly consumed. The consumption of specific food groups, such as table sweeteners, light soft drinks, Radler, protein shakes, and stevia sweeteners, accounted for significant variations in urinary concentrations. Specific combinations of LNCS were observed for these food groups, as well as a considerable exploitation of LNCS-specific ADI (acceptable daily intake).</p><p><strong>Conclusion: </strong>Individuals who consume high amounts of specific LNCS-containing, processed foods are exposed to a notable mix of various LNCS. Since data on associations between mixed LNCS exposure and health are lacking, it is an urgent issue to evaluate the potential risks of consuming combinations of diverse LNCS rather than conducting risk assessments of single LNCS.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"136"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-faceted nutritional science demonstrated through the prism of sugar: a scoping review on sugar intake and association with quality of life in children and adolescents.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-24 DOI: 10.1007/s00394-025-03648-3
Stefania Noerman, Ute Nöthlings, Danijela Ristić-Medić, Bryndís Eva Birgisdóttir, Inge Tetens, Marjukka Kolehmainen
{"title":"Multi-faceted nutritional science demonstrated through the prism of sugar: a scoping review on sugar intake and association with quality of life in children and adolescents.","authors":"Stefania Noerman, Ute Nöthlings, Danijela Ristić-Medić, Bryndís Eva Birgisdóttir, Inge Tetens, Marjukka Kolehmainen","doi":"10.1007/s00394-025-03648-3","DOIUrl":"10.1007/s00394-025-03648-3","url":null,"abstract":"<p><strong>Background: </strong>To strengthen the scientific evidence linking dietary sugar consumption with health outcomes, it's essential to look beyond the usual focus on non-communicable diseases (NCDs) and tooth decay. We thus hypothesize that considering other dimensions of health beyond physical health will meaningfully complement the evidence and expand our understanding of the relationship between nutrition and health.</p><p><strong>Purpose: </strong>The aim of this scoping review was to explore the scientific evidence of an association between dietary sugar intake and quality of life (QoL) among healthy children and adolescents.</p><p><strong>Methods: </strong>We performed a literature search in three databases (i.e., PubMed, Scopus, and Web of Science). The search included all types of studies assessing dietary sugar intake in association with QoL, in children and adolescents published in English between January 2001 and January 2023.</p><p><strong>Results: </strong>Twenty-one full-text eligible papers were included in this review: one intervention, two prospective cohort studies, and 18 cross-sectional studies. The number of participants ranged from 25 to 65,000 and age of the participants ranged from 4 to 19 years. The studies differed considerably in exposure and outcome measures. For further qualitative analyses, the studies were categorized into studies related to different dimensions of QoL: food security (n = 4), sleep-related outcomes (n = 5), oral (n = 3) and (mental) health-related QoL (n = 9). Altogether, one study reported a null while the remaining 20 studies found adverse associations between intake of sugar, sugar-sweetened beverages (SSB), or sweets and outcome measures of QoL.</p><p><strong>Conclusion: </strong>Through this scoping review, a number of scientific studies have revealed an association between sugar intake among children and adolescents and health-related QoL. The findings underscore a negative association. Our review emphasizes the crucial imperative of embracing a broader spectrum of health dimensions to gain a more wholistic understanding of nutrition, especially in collecting science-based evidence for the development of health policies, including dietary guidelines.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"137"},"PeriodicalIF":4.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-22 DOI: 10.1007/s00394-025-03586-0
Lonneke JanssenDuijghuijsen, Maartje van den Belt, Iris Rijnaarts, Paul Vos, Damien Guillemet, Ben Witteman, Nicole de Wit
{"title":"Correction to: Acacia fiber or probiotic supplements to relieve gastrointestinal complaints in patients with constipation-predominant IBS: a 4-week randomized double-blinded placebo-controlled intervention trial.","authors":"Lonneke JanssenDuijghuijsen, Maartje van den Belt, Iris Rijnaarts, Paul Vos, Damien Guillemet, Ben Witteman, Nicole de Wit","doi":"10.1007/s00394-025-03586-0","DOIUrl":"10.1007/s00394-025-03586-0","url":null,"abstract":"","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"135"},"PeriodicalIF":4.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late eating and shortened fasting are associated with higher ultra-processed food intake across all age groups: a population-based study.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-21 DOI: 10.1007/s00394-025-03633-w
Cibele A Crispim, Catarina M Azeredo, Ana E M Rinaldi, Alexessander Couto Alves, Debra J Skene, Claudia R C Moreno
{"title":"Late eating and shortened fasting are associated with higher ultra-processed food intake across all age groups: a population-based study.","authors":"Cibele A Crispim, Catarina M Azeredo, Ana E M Rinaldi, Alexessander Couto Alves, Debra J Skene, Claudia R C Moreno","doi":"10.1007/s00394-025-03633-w","DOIUrl":"https://doi.org/10.1007/s00394-025-03633-w","url":null,"abstract":"<p><strong>Purpose: </strong>Global dietary patterns are increasingly driven by ultra-processed foods-cheap, highly palatable, and ready-to-eat options. Exploring time-related eating patterns and its association with ultra-processed foods could help in intervention efforts, but knowledge on this topic is still limited. This study assessed the association of time-related eating patterns with unprocessed/minimally processed and ultra-processed food consumption across different life stages.</p><p><strong>Methods: </strong>Two 24-hour food recalls from a nationally representative sample in Brazil (Brazilian Household Budget Survey, POF, 2017-2018; n = 46,164) were used to estimate tertiles of first and last intake times, eating midpoint, caloric midpoint time, and night fasting (independent variables). All consumed foods were classified according to the Nova classification system, and the outcomes of interest were consumption of unprocessed/minimally processed and ultra-processed foods. Multiple linear regression models were performed for all individuals and stratified for each age group: adolescents (10-19 years, n = 8,469), adults (20-59 years, n = 29,332), and older individuals (≥ 60 years, n = 8,322).</p><p><strong>Results: </strong>The later tertile of first food intake time, last food intake time, caloric midpoint, and eating midpoint were positively associated with consumption of ultra-processed foods (β = 3.69, 95%CI = 3.04, 4.34; β = 1.89, 95%CI = 1.32, 2.47; β = 5.20, 95%CI = 4.60, 5.81; β = 3.10, 95%CI = 2.49, 3.71, respectively) and negatively associated with consumption of unprocessed or minimally processed foods (β=-2.79, 95%CI=-3.37; -2.22; β=-1.65, 95%CI=-2.24, -1.05; β=-3.94, 95%CI=-4.44, -3.44; β=- 2.35, 95%CI=-2.93, -1.78, respectively) compared to the first \"earlier\" tertile (reference). An inverse association was found for night fasting (β=-1.74, 95%CI=-2.28, -1.22 and β = 1.52, 95%CI = 0.98, 2.06 for ultra-processed and unprocessed/minimally processed foods, respectively). These associations were consistent across all age groups.</p><p><strong>Conclusion: </strong>Chrononutrition patterns characterized by late intake timing and shortened overnight fasting were associated with higher consumption of ultra-processed foods and lower intake of unprocessed/minimally processed foods across all age groups.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"134"},"PeriodicalIF":4.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolating the acute metabolic effects of carbohydrate restriction on postprandial metabolism with or without energy restriction: a crossover study.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-20 DOI: 10.1007/s00394-025-03646-5
Hayriye Biyikoglu, M Denise Robertson, Adam L Collins
{"title":"Isolating the acute metabolic effects of carbohydrate restriction on postprandial metabolism with or without energy restriction: a crossover study.","authors":"Hayriye Biyikoglu, M Denise Robertson, Adam L Collins","doi":"10.1007/s00394-025-03646-5","DOIUrl":"10.1007/s00394-025-03646-5","url":null,"abstract":"<p><p>Low-carbohydrate diets and intermittent energy restriction may offer metabolic advantages in fuel utilisation, that are independent of weight loss. The underlying mechanisms for these effects are unclear but may involve extensions of the catabolic phase and/or attenuation of insulin secretion. To address this gap, we aimed to investigate the independent acute metabolic effect of carbohydrate restriction at varying energy levels. Twelve, (six female) healthy overweight/obese participants (27.3 ± 1.8 years; 25.2 ± 1.6 kg/m<sup>2</sup>) completed this three-way study. Volunteers followed three diets for one day (36 h, covering the intervention day and overnight fasting), separated by 5-day washout: a normal carbohydrate, energy-balanced diet (nEB, 55% CHO), a low-carbohydrate, energy-balanced diet (LCEB, 50 g/day CHO), and a low-carbohydrate, energy-restricted diet (LC25, 50 g/day CHO with 75% energy restriction). Fasting and serial postprandial (360 min) measurements to a mixed test meal were collected the following morning. Additionally, subjective appetite responses and two-day subsequent ad libitum food intake was assessed. Both low-carbohydrate with and without energy restriction diets induced comparable decrease in triacylglycerol iAUC (p = 0.02, p = 0.04, respectively), and respiratory quotient (both p < 0.01) along with increase in non-esterified fatty acids (both p < 0.01) and 3-hydroxybutyrate (p = 0.001, p = 0.01, respectively) levels. Compared to a non-restricted carbohydrate, energy-balanced diet, postprandial glucose levels significantly increased in the LCEB arm (p = 0.024) and showed a rising trend in the LC25 arm (p = 0.07). Neither insulin responses nor resting, and diet-induced thermogenesis were significantly altered by variations in energy or carbohydrate content. These findings demonstrate that carbohydrate restriction, without altering energy intake, can elicit effects similar to those observed in short-term fasting. As such we propose a strategy of repeated carbohydrate restriction cycles alone may be an emerging alternative approach for the enhancement of cardiometabolic health, warranting further investigation.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"133"},"PeriodicalIF":4.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary branched-chain amino acids intake and coronary artery calcium progression: insights from the coronary artery risk development in young adults (CARDIA) study.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-19 DOI: 10.1007/s00394-025-03649-2
Qing-Yun Hao, Jun Weng, Ting-Ting Zeng, Yu-Hong Zeng, Jing-Bin Guo, Shi-Chao Li, Yi-Ran Chen, Ping-Zhen Yang, Jing-Wei Gao, Ze-Hua Li
{"title":"Dietary branched-chain amino acids intake and coronary artery calcium progression: insights from the coronary artery risk development in young adults (CARDIA) study.","authors":"Qing-Yun Hao, Jun Weng, Ting-Ting Zeng, Yu-Hong Zeng, Jing-Bin Guo, Shi-Chao Li, Yi-Ran Chen, Ping-Zhen Yang, Jing-Wei Gao, Ze-Hua Li","doi":"10.1007/s00394-025-03649-2","DOIUrl":"https://doi.org/10.1007/s00394-025-03649-2","url":null,"abstract":"<p><strong>Objective: </strong>Branched-chain amino acids (BCAA) have been implicated in the risk of cardiovascular disease. However, it is unclear whether dietary BCAA intake, specifically isoleucine, leucine, and valine are associated with coronary artery calcium (CAC) progression.</p><p><strong>Methods: </strong>We included the participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study cohort for the analysis. Dietary intake of BCAA was assessed at year 7 of the study. CAC was measured using standardized computed tomography scans at years 15, 20, and 25. CAC progression was defined as follows: for participants with a baseline CAC of 0, progression was defined as CAC > 0 at follow-up; for those with 0 < baseline CAC < 100, progression was defined as an annualized change of ≥ 10; and for those with baseline CAC ≥ 100, progression was defined as an annualized percent change of ≥ 10%. Multivariate adjusted Cox regression models were utilized to examine the associations between BCAA intake and CAC progression.</p><p><strong>Results: </strong>Among 2381 included participants (average age 40.4 ± 3.5 years, 44.9% men), 629 participants (26.4%) exhibited CAC progression during a follow-up period of 8.90 ± 2.03 years. In the fully adjusted model, high intake of total BCAA, and its individual components, isoleucine, leucine, and valine were associated with an increased risk of CAC progression by 35.6% (HR, 1.356 [95% CI, 1.040-1.769]), 30.5% (HR, 1.305 [95% CI, 1.001-1.701]), 30.9% (HR, 1.309 [95% CI, 1.003-1.706]), and 33.9% (HR, 1.339 [95% CI, 1.026-1.747]), respectively, compared to their corresponding low intake groups. The associations were consistent across various subgroups, including age, sex, race, and body mass index, but were stronger in participants without baseline CAC (interaction P < 0.001). These results remained robust in a series of sensitivity analyses.</p><p><strong>Conclusions: </strong>High dietary intake of BCAA, including isoleucine, leucine, and valine, were independently associated with an increased risk of CAC progression. The findings may implication for dietary modifications in primary prevention of subclinical atherosclerosis.</p><p><strong>Registration: </strong>URL: https://www.</p><p><strong>Clinicaltrials: </strong>gov ; Unique identifier: NCT00005130.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"131"},"PeriodicalIF":4.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fisetin alleviates Salmonella typhimurium-induced colitis through the TLR2/TLR4-NF-κB pathway, regulating microbiota, and repressing intracellular bacterial proliferation by focal adhesion kinase.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-19 DOI: 10.1007/s00394-025-03602-3
Jun Li, Yang Yang, Xinyu Zhang, Ying Yang, Zhenlong Wu
{"title":"Fisetin alleviates Salmonella typhimurium-induced colitis through the TLR2/TLR4-NF-κB pathway, regulating microbiota, and repressing intracellular bacterial proliferation by focal adhesion kinase.","authors":"Jun Li, Yang Yang, Xinyu Zhang, Ying Yang, Zhenlong Wu","doi":"10.1007/s00394-025-03602-3","DOIUrl":"https://doi.org/10.1007/s00394-025-03602-3","url":null,"abstract":"<p><strong>Background: </strong>Salmonella typhimurium is a pathogen responsible for millions of cases of gastroenteritis in both humans and animals. This study aimed to evaluate the hypothesis that fisetin administration could mitigate colon damage and regulate the intestinal microbiota in mice treated with Salmonella typhimurium.</p><p><strong>Methods: </strong>Six-week-old male mice were orally administered with or without 100 mg/kg fisetin and infected with Salmonella typhimurium.</p><p><strong>Results: </strong>Fisetin administration ameliorated Salmonella typhimurium-induced colitis as shown by the decreased body weight loss, lowered disease activity index score, reduced colon shortening, inflammatory infiltration, and apoptosis. Meanwhile, Salmonella typhimurium exposure upregulated colonic Tnf-α, Il-6, Il-1β, Ifn-β, Ccl2, Ccl8 relative expression and MDA and H<sub>2</sub>O<sub>2</sub> concentrations, whereas lowered Il-10, Nrf2, Nqo1, Coq10b, and Gss abundance, all of which were ameliorated by fisetin treatment. Moreover, fisetin recovered the occludin, zonula occludens-1, and zonula occludens-2 protein abundance in response to Salmonella typhimurium administration. Further investigation demonstrated that the protective role of fisetin was related to the inactivation of the TLR2/TLR4-NF-κB pathway, upregulation of Lactobacillus, and reduction of Salmonella abundance. Additionally, fisetin could limit the intracellular Salmonella typhimurium proliferation, which was likely to be attributed to the inhibition of focal adhesion kinase.</p><p><strong>Conclusion: </strong>Together, our study elucidated the therapeutic potential of fisetin in ameliorating key aspects of colitis, including intestinal inflammation, oxidative stress, and barrier dysfunction, and these beneficial effects were mediated through the inactivation of the TLR2/TLR4-NF-κB pathway, the regulation of microbiota, and restricting the intracellular proliferation of Salmonella typhimurium by inhibiting focal adhesion kinase.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"128"},"PeriodicalIF":4.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inadequate consumption of dietary fatty acids is a risk factor for ovarian cancer: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-19 DOI: 10.1007/s00394-025-03650-9
Jiahui Lao, Yifan Wei, Fanghua Liu, Tingting Gong, Qijun Wu
{"title":"Inadequate consumption of dietary fatty acids is a risk factor for ovarian cancer: evidence from the prostate, lung, colorectal, and ovarian cancer screening trial.","authors":"Jiahui Lao, Yifan Wei, Fanghua Liu, Tingting Gong, Qijun Wu","doi":"10.1007/s00394-025-03650-9","DOIUrl":"https://doi.org/10.1007/s00394-025-03650-9","url":null,"abstract":"<p><strong>Purpose: </strong>Currently, there is controversy surrounding the association between dietary fatty acids (FAs) and ovarian cancer (OC) risk. We aimed to elucidate the aforementioned topic using data from a large cohort.</p><p><strong>Methods: </strong>Women participating in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial were included in this study. The dietary information of participants was collected through the diet history questionnaire. Multivariable Cox proportional hazards regression models incorporating restricted cubic splines were constructed to explore the association between dietary FAs intake and the incidence of OC.</p><p><strong>Results: </strong>Among 50,614 participants in the present study, a total of 277 cases of ovarian cancer were diagnosed. The median follow-up time was 9.44 years. Non-significant association between total FAs intake and risk of OC was observed (non-linear P = 0.060). Compared to the median of total FAs intake, hazard ratios were 1.68 (95% CI: 1.10-2.58) and 1.45 (95% CI: 1.05-1.99) for the 5th percentile and 10th percentile, respectively, while consuming more than the median failed to show significant findings. Similar results were found in the analyses of different types (saturated fatty acids, monounsaturated fatty acids, and polyunsaturated fatty acids) and sources (animals and plants) of dietary FAs.</p><p><strong>Conclusion: </strong>Inadequate consumption of various types and sources of dietary FAs might be associated with an increased risk of OC.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"132"},"PeriodicalIF":4.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Consumer attitudes towards dietary behaviors: a mediator between socioeconomic status and diet quality in European adults.
IF 4.1 2区 医学
European Journal of Nutrition Pub Date : 2025-03-19 DOI: 10.1007/s00394-025-03645-6
Urte Klink, Timm Intemann, Leonie H Bogl, Lauren Lissner, Wencke Gwozdz, Stefaan De Henauw, Dénes Molnár, Artur Mazur, Luis A Moreno, Valeria Pala, Paola Russo, Michael Tornaritis, Toomas Veidebaum, Garrath Williams, Antje Hebestreit, Benjamin Schüz
{"title":"Consumer attitudes towards dietary behaviors: a mediator between socioeconomic status and diet quality in European adults.","authors":"Urte Klink, Timm Intemann, Leonie H Bogl, Lauren Lissner, Wencke Gwozdz, Stefaan De Henauw, Dénes Molnár, Artur Mazur, Luis A Moreno, Valeria Pala, Paola Russo, Michael Tornaritis, Toomas Veidebaum, Garrath Williams, Antje Hebestreit, Benjamin Schüz","doi":"10.1007/s00394-025-03645-6","DOIUrl":"10.1007/s00394-025-03645-6","url":null,"abstract":"<p><strong>Background: </strong>Socioeconomic disparities in dietary behaviors are well-known, but underlying mechanisms are not fully understood. We investigated whether consumer attitudes toward dietary behaviors mediate the relationship between socioeconomic factors and diet quality.</p><p><strong>Methods: </strong>This analysis included 4051 adult participants from eight European countries of the I.Family study (2013/2014). Dietary intake was assessed using a food frequency questionnaire, and diet quality was measured by adherence to dietary recommendations using the Healthy Dietary Adherence Score. Socioeconomic factors included education, income, and social vulnerabilities (migrant background, experiencing unemployment in the household, single parenthood). Structural equation modeling was used to model pathways between predictors, outcome, and mediators, which also allowed for accounting of the clustered study design, incorporating random intercepts for country.</p><p><strong>Results: </strong>Education and income were positively, and unemployment was negatively associated with diet quality. Attitudes reflecting favorable dietary behaviors were positively associated with diet quality, while unfavorable attitudes were inversely associated. Analysis of the path between socioeconomic factors and attitudes revealed a heterogeneous association pattern. Trusting food advertisements and frequently using ready-to-eat foods partially mediated the association between education, income, and diet quality. The association between single parenthood and diet quality was fully mediated by comparing food labels, valuing organic products, and using ready-to-eat foods.</p><p><strong>Conclusion: </strong>Our findings suggest a mediating role of consumer attitudes in the association between socioeconomic factors and diet quality, but results were not consistent across socioeconomic factors. Our findings may inform the development of interventions and regulations promoting healthy diet, such as restricting food advertisments.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":"64 3","pages":"127"},"PeriodicalIF":4.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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