European Journal of Nutrition最新文献

{"title":"Evaluating the diet in Germany with two indices focusing on healthy eating and planetary healthy eating using nationwide cross-sectional food intake data from DEGS1 (2008-2011).","authors":"Almut Richter, Julika Loss, Daria-Alina Kuhn, Ramona Moosburger, Gert B M Mensink","doi":"10.1007/s00394-024-03476-x","DOIUrl":"10.1007/s00394-024-03476-x","url":null,"abstract":"<p><strong>Purpose: </strong>To improve sustainability, adjustments to current diets are necessary. Therefore, limited planetary resources are considered within the healthy reference diet proposed by the EAT-Lancet Commission. The agreement with nationwide food intake was evaluated with two indices which reflect this reference and German food intake recommendations.</p><p><strong>Methods: </strong>A healthy eating index (HEI-MON) reflecting the dietary guidelines of the German nutrition society and a planetary healthy eating index (PHEI-MON) reflecting the healthy reference diet were developed, with scores from 0 to 100. Both indices were applied to data from a nationally representative sample of the German population aged 18-79 years for which data from a 53-item food frequency questionnaire are available.</p><p><strong>Results: </strong>Mean scores for the indices were 53 for HEI-MON and 39 for PHEI-MON. A better adherence to either guideline could be found among women, persons of older age as well as persons with higher education level. The sub-scores for HEI-MON showed high agreement with the recommendations for side dishes, fruit/nuts, (processed) meat and cereals, but low agreement with the recommendations for free sugar and vegetables/legumes. PHEI-MON sub-scores were highest for poultry, fruits and potatoes, and lowest for nuts, red meat and legumes. High scores in one index do not necessarily correspond to high scores in the other index. Individuals with more plantbased diets had higher scores in both indices, while high sugar and meat consumption led to lower scores.</p><p><strong>Conclusions: </strong>More plant-based diets are crucial for individual and planetary health. Both indices reflect such diets which consider already health and sustainability aspects. At an individual level, the scores for both indices may differ considerably, but overall there is a huge potential in the population to adapt to a diet more in line with both guidelines.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"2943-2956"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141987636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary folic acid intake, 13 genetic variants and other factors with red blood cell folate concentration in pregnancy-preparing population.","authors":"Wennan He, Yi Zhang, Xiaotian Chen, Yalan Dou, Yuanchen He, Weili Yan","doi":"10.1007/s00394-024-03474-z","DOIUrl":"10.1007/s00394-024-03474-z","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to evaluate a combined effect of dietary folic acid intake, multiple genetic polymorphisms in folate metabolism, and other environmental factors on red blood cell (RBC) folate concentration in pregnancy-preparing population.</p><p><strong>Methods: </strong>519 pregnancy-preparing subjects (260 couples) were investigated. Dietary intake was measured by 3-day dietary recalls. 13 Single Nucleotide polymorphisms (SNPs) reported in association with one-carbon metabolism including the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C were genotyped. RBC folate concentration was measured using chemiluminescence assay. Hierarchical regression was applied for covariate selection. Factors showed significance(p < 0.0125) on RBC folate level was included for prediction model construction and R² estimation. Validation cohort analysis was performed as post-hoc analysis if applicable.</p><p><strong>Results: </strong>The median RBC folate was 212.8 ng/ml. Only 10% took folic acid supplementation within three months. Based on hierarchical selection, folic acid supplementation, genetic polymorphism (especially TT genotype of MTHFR C677T), serum folate level were determinants of the variance of RBC folate concentrations, with adjusted R² of 0.178-0.242. MTHFR A1298C polymorphism, sex difference with other socio-demographic and lifestyle factors (age, BMI, alcohol drinking, smoking, education, occupation) explained little to change in RBC folate level. Validation in another sub-cohort(n = 8105) had adjusted R² of 0.273.</p><p><strong>Conclusion: </strong>In pregnancy-preparing subjects, folic acid supplementation, serum folate level and TT allele of MTHFR C677T polymorphism were determinants of the total variance of RBC folate level, which explained 19.8% variance in our subjects and 27.3% in the validation cohort. Food folate intake, sex and other environmental factors explained little to RBC folate level.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"2921-2931"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between different diet quality scores and depression risk: the REGICOR population-based cohort study.","authors":"Gabriela Lugon, Álvaro Hernáez, Felice N Jacka, Jaume Marrugat, Rafael Ramos, Josep Garre-Olmo, Roberto Elosua, Camille Lassale","doi":"10.1007/s00394-024-03466-z","DOIUrl":"10.1007/s00394-024-03466-z","url":null,"abstract":"<p><strong>Background: </strong>Our aim was to determine the association between diet quality and depression incidence in the population-based REGICOR cohort study, Catalonia, Spain.</p><p><strong>Methods: </strong>Prospective observational study using participants' baseline (2003-2006), follow-up (2007-2013) and clinical records data. Five diet quality scores were derived from a food frequency questionnaire (FFQ) at baseline: the relative Mediterranean Diet Score (rMED), the Modified Mediterranean Diet Score (ModMDS), a Dietary Approaches to Stop Hypertension (DASH) score, a Healthful Plant-based Diet Index (HPDI) and the World Health Organization Healthy Diet Indicator (WHO-HDI). Participants using pharmacological antidepressant treatment were excluded as a proxy for presence of depression at baseline. At follow-up, the Patient Health Questionnaire (PHQ-9) was applied to assess depressive symptoms (≥ 10 defining depressive disorder). A secondary outcome was depression diagnosis assessed through clinical records. Logistic regression and Cox proportional hazards models were used.</p><p><strong>Results: </strong>Main analysis included 3046 adults (50.3% women) with a mean age of 54.7 (SD = 11.6) years. After 6-years follow-up, 184 (6.04%) cases of depressive disorder were identified. There was 16% lower odds of depressive disorder per 1SD increase of rMED (OR = 0.84; 95%CI = 0.71-0.98). Secondary outcome analysis (n = 4789) identified 261 (5.45%) incident cases of clinical depression diagnosis over 12 years follow-up, and 19% lower risk of clinical depression was observed with the WHO-HDI (HR = 0.81; 95%CI = 0.70-0.93). Adjusting for BMI did not attenuate the findings.</p><p><strong>Conclusions: </strong>A significant inverse association between diet quality and depression incidence was found in this population-based cohort study, independent of sociodemographic, health and lifestyle. Adherence to a healthy diet could be a complementary intervention for the prevention of depression.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"2885-2895"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of ultra-processed foods in plant-based diets: associations with human health and environmental sustainability.","authors":"Merel C Daas, Reina E Vellinga, Maria Gabriela M Pinho, Jolanda M A Boer, W M Monique Verschuren, Yvonne T van der Schouw, Pieter Van't Veer, Sander Biesbroek","doi":"10.1007/s00394-024-03477-w","DOIUrl":"10.1007/s00394-024-03477-w","url":null,"abstract":"<p><strong>Purpose: </strong>Investigate the associations of ultra-processed foods (UPF) in healthful (hPDI) and unhealthful (uPDI) plant-based diets with all-cause mortality, greenhouse gas emissions (GHGE), and blue water consumption (BWC).</p><p><strong>Methods: </strong>Analyses were based on 35,030 participants (20-70 years; 74% females) from the EPIC-NL cohort who were followed up from 1993 to 1997 through 2014. Plant-based diet indices (hPDI and uPDI) and UPF consumption were calculated from a validated FFQ, assessed at baseline. Cox proportional hazard and multiple linear regression models were used to estimate associations between combined quartiles of the PDI indices and UPF consumption.</p><p><strong>Results: </strong>With lower hPDI and higher UPF diets as the reference, we observed the following. Risk estimates of all-cause mortality were 0.98 (95% CI: 0.83, 1.16) for lower UPF consumption, 0.86 (95% CI: 0.68, 1.08) for higher hPDI, and 0.78 (95% CI: 0.66, 0.89) for combined higher hPDI and lower UPF consumption. Results with the uPDI were inconclusive. Mean differences in GHGE and BWC were 1.4% (95% CI: 0.3, 2.4) and 1.6% (95% CI: -0.5, 3.7) for lower UPF consumption, -7.4% (95% CI: -8.6, -6.4) and 9.6% (95% CI: 7.2, 12.0) for higher hPDI, and - 6.8% (95% CI: -7.4, -6.1) and 13.1% (95% CI: 11.6, 14.8) for combined higher hPDI and lower UPF consumption. No apparent conflict between environmental impacts was observed for the uPDI; GHGE and BWC were lower for higher uPDI scores.</p><p><strong>Conclusion: </strong>Mortality risk and environmental impacts were mostly associated with the amount of plant-based foods and to a lesser extent UPF in the diet. Shifting to a more healthful plant-based diet could improve human health and reduce most aspects of environmental impact (GHGE, but not BWC) irrespective of UPF consumption.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"2957-2973"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chinese-modified MIND Diet and subjective well‑being in adults aged 60 years or older in China: a national community-based cohort study.","authors":"Afei Qin, Meiqi Wang, Haifeng Yang, Tianjiao Xin, Lingzhong Xu","doi":"10.1007/s00394-024-03484-x","DOIUrl":"10.1007/s00394-024-03484-x","url":null,"abstract":"<p><strong>Objective: </strong>Observing the dietary principles of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet has exhibited an association with a diminished occurrence of diverse ailments, enhanced mental well-being, and extended longevity. Nevertheless, current literature is deficient in terms of investigating the link between the MIND diet and subjective well-being (SWB) specifically in older adults. Hence, this study endeavors to examine the correlation between adhering to a Chinese-modified Mediterranean-DASH Intervention for Neurodegenerative Delay (cMIND) diet and SWB in the older Chinese adults, taking into account the unique dietary attributes of the Chinese population.</p><p><strong>Methods: </strong>Using data from the latest four waves of the Chinese Longitudinal Healthy Longevity Survey. Multiple linear regression and multinomial ordered logistic regression were employed to examine the relationship between the duration of adherence to cMIND diet and SWB in Chinese older adults.</p><p><strong>Results: </strong>The results indicated a significant association between the duration of adherence to cMIND diet and SWB (1 ∼ 6 years: B = 0.907, 95%CI = 0.508 ∼ 1.307, P < 0.001; 7 ∼ 9 years: B = 1.286, 95%CI = 0.767 ∼ 1.805, P < 0.001; 10 years and above: B = 2.320, 95%CI = 1.677 ∼ 2.963, P < 0.001). The longer the duration of adherence to cMIND diet, the higher the scores for life satisfaction (B = 0.184, 95%CI = 0.110 ∼ 0.259; B = 0.312, 95%CI = 0.217 ∼ 0.407; B = 0.321, 95%CI = 0.193 ∼ 0.448), positive affect (B = 0.434, 95%CI = 0.209 ∼ 0.658; B = 0.701, 95%CI = 0.400 ∼ 1.003; B = 1.167, 95%CI = 0.775 ∼ 1.559), and negative affect (B = 0.289, 95%CI = 0.078 ∼ 0.500; B = 0.832, 95%CI = 0.479 ∼ 1.185), suggesting a higher SWB score. Sensitivity analysis further supports our findings.</p><p><strong>Conclusion: </strong>Considering the poor knowledge, attitudes, and behaviors related to diet among Chinese adults, especially older adults, it is imperative to implement dietary policies that promote SWB in older adults to enhance their happiness in later life.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"2999-3012"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comprehensive analysis of fruit, vegetable, and legume consumption and the risk of hypertension: results from the KoGES_CAVAS cohort.","authors":"Ji-Sook Kong, Yu-Mi Kim, Min-Ho Shin, Sang Baek Koh, Hyeon Chang Kim, Jinho Shin, Mi Kyung Kim","doi":"10.1007/s00394-024-03503-x","DOIUrl":"10.1007/s00394-024-03503-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the association between total consumption of fruits (F), vegetables (V), and legumes (L) and their subgroups and hypertension risk in adults aged ≥ 40 years in the Cardiovascular Disease Association Study (CAVAS).</p><p><strong>Methods: </strong>We analyzed data from 10,325 normotensive participants using cumulative average dietary consumption from repeated food frequency questionnaires during the follow-up. Incidence rate ratios (IRRs) were estimated with a modified Poisson regression model and a robust error estimator to evaluate the association between hypertension risk and total consumption of fruits, vegetables, and legumes, as well as their 17 subgroups.</p><p><strong>Results: </strong>During an average follow-up of 5.20 years, 2159 cases of hypertension were recorded. Total consumption of FVL, FV, fruits, vegetables, and legumes showed overall inverse trends with hypertension risk. Considering multiplicity, fruit consumption was inversely associated with hypertension risk in both men (IRR 0.64; 95% CI 0.52-0.79) and women (IRR 0.76; 95% CI 0.64-0.91). Vegetables were inversely associated with hypertension in women (IRR 0.67; 95% CI 0.53-0.86). Most subgroups showed inverse associations, especially in men with overweight/obesity. However, frequent pickled green leafy vegetable consumption was positively associated with hypertension risk in postmenopausal women but not in premenopausal women (P_interaction = 0.0004).</p><p><strong>Conclusion: </strong>Consumption of FVL, including their subgroups, generally shows inverse associations with hypertension risk. However, caution is advised for recommending pickled vegetables, particularly for postmenopausal women, due to the potential adverse effects of sodium. The benefits of these foods in preventing hypertension are especially pronounced in men with overweight/obesity.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"3235-3253"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of roasted purple laver (nori) on vitamin B₁₂ nutritional status of vegetarians: a dose-response trial.","authors":"Qian-Ni Huang, Fumio Watanabe, Kyohei Koseki, Rui-En He, Hui-Ling Lee, Tina H T Chiu","doi":"10.1007/s00394-024-03505-9","DOIUrl":"10.1007/s00394-024-03505-9","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the bioavailability of vitamin B₁₂ from nori and to evaluate the required dosage for improving vitamin B₁₂ nutritional status in vegetarians not using supplements.</p><p><strong>Methods: </strong>The study design is an open-label, parallel, dose-response randomized controlled trial. Thirty vegetarians were assigned to control (no nori), low-dose (5 g nori, aiming to provide 2.4 µg vitamin B₁₂ per day), or high-dose (8 g nori, aiming to provide 4 µg vitamin B₁₂ per day) groups. The primary outcome was changes in vitamin B₁₂ status as measured by serum vitamin B₁₂, holotranscobalamin (holoTC), homocysteine (Hcy), and methylmalonic acid (MMA), and a combined score of these four markers (4cB12 score) during the four-week intervention. Dietary vitamin B₁₂ intakes were assessed at baseline and end of the trial with a 17-item food frequency questionnaire designed for vitamin B₁₂ assessment. General linear model was used to compare least square means of changes in each biomarker of vitamin B₁₂ status, among the three groups, while adjusting for respective baseline biomarker.</p><p><strong>Results: </strong>After adjusting for baseline status, nori consumption led to significant improvement in serum vitamin B₁₂ (among-group P-value = 0.0029), holoTC (P = 0.0127), Hcy (P = 0.0225), and 4cB12 (P = 0.0094). Changes in MMA did not differ significantly across groups, but showed within-group pre-post improvement in the low-dose group (median [p25, p75] = -339 [-461, -198] nmol/L). Vitamin B₁₂ status appeared to plateau at low dose (5 g of nori), which compared with control group, improved serum vitamin B₁₂ (lease square mean [95% CI] = + 59 [25, 93] pmol/L, P = 0.0014); holoTC (+ 28.2 [10.1, 46.3] pmol/L, P = 0.0035); Hcy (-3.7 [-6.8, -0.6] µmol/L, p = 0.0226); and 4cB12 score (+ 0.67 [0.24, 1.09], p = 0.0036). High-dose resulted in similar improvements. There was no significant difference between low-dose and high-dose groups in all biomarkers of vitamin B₁₂.</p><p><strong>Conclusions: </strong>Consuming 5 g of nori per day for 4 weeks significantly improved vitamin B₁₂ status in vegetarians. A higher dose (8 g) may not confer additional benefits.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov Identifier: NCT05614960. Date of registration: November 14th 2022.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"3269-3279"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different doses of caffeine on cognitive performance in healthy physically active individuals.","authors":"María Ramírez-delaCruz, Paula Esteban-García, Pablo Abián, Alfredo Bravo-Sánchez, Inés Piñas-Bonilla, Javier Abián-Vicén","doi":"10.1007/s00394-024-03486-9","DOIUrl":"10.1007/s00394-024-03486-9","url":null,"abstract":"<p><strong>Purpose: </strong>Caffeine is a potent central nervous system stimulant that increases the activity of the prefrontal cortex and can improve various cognitive skills. An improvement in these cognitive skills can lead to further benefits in athletic performance. Therefore, it is necessary to clarify the dose-response of caffeine on cognitive performance. This study aimed to determine the effects of different doses of caffeine on sport-related cognitive aspects.</p><p><strong>Methods: </strong>Twenty-nine healthy physically active young adults were recruited. All participants completed three trials under the following conditions: (a) placebo, (b) 3 mg/kg, or (c) 6 mg/kg body mass of caffeine. In each trial, different cognitive abilities were evaluated with the following battery of tests: reaction time (Dynavision™ D2), anticipation (Bassin Anticipation Timer), sustained attention (Go/No-Go and Eriksen Flanker Test) and memory tests. Moreover, the side effects and the perceived sensation index were recorded 24 h after each test.</p><p><strong>Results: </strong>Reaction time only improved following 6 mg/kg of caffeine intake (Physical reaction time: -0.04 s, 95% CI -0.08 to -0.01 s, P = 0.036, d = 0.5; Motor reaction time: -0.04 s, 95% CI -0.07 to -0.01 s, P = 0.008, d = 0.6) compared to the placebo condition. Anticipation, sustained attention, and memory were not affected after either caffeine dose intake (all P > 0.05). In addition, the 6 mg/kg dose of caffeine augmented the occurrence of the side effects of increased activeness (P = 0.046) and nervousness (P = 0.001).</p><p><strong>Conclusion: </strong>Acute intake of 6 mg/kg caffeine is effective in improving reaction time despite increasing the occurrence of side effects in healthy physically active young adults.</p><p><strong>Study registration: </strong>This study has been registered in ClinicalTrials whose ID is: NCT05995314 (2023-08-08).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"3025-3035"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomal delivery enhances absorption of vitamin C into plasma and leukocytes: a double-blind, placebo-controlled, randomized trial.","authors":"Martin Purpura, Ralf Jäger, Ashok Godavarthi, Dhananjaya Bhaskarachar, Grant M Tinsley","doi":"10.1007/s00394-024-03487-8","DOIUrl":"10.1007/s00394-024-03487-8","url":null,"abstract":"<p><strong>Purpose: </strong>L-Ascorbic acid (vitamin C) is an essential water-soluble vitamin that plays an important role in various physiological functions, including immune health. The stability of vitamin C in the gastrointestinal tract its bioavailability is limited. This study aimed to investigate if a liposomal form of vitamin C can increase absorption compared to standard vitamin C.</p><p><strong>Methods: </strong>In a randomized, double-blind, placebo-controlled, crossover fashion, 19 males and 8 females (n = 27; 36.0 ± 5.1 years, 165.0 ± 6.9 cm, 70.6 ± 7.1 kg) ingested a single-dose of placebo (PLA), 500 mg vitamin C (VIT C), and 500 mg liposomal vitamin C (LV-VIT C, LipoVantage^®, Specnova, LLC, Tyson Corner, VA, USA). Venous blood samples were collected 0, 0.5-, 1-, 1.5-, 2-, 3-, 4-, 6-, 8-, 12-, and 24-hours after ingestion and were analyzed for plasma and leukocyte vitamin C concentration.</p><p><strong>Results: </strong>VIT C and LV-VIT C demonstrated significantly greater Cmax and AUC_0 - 24 in plasma and in leukocytes compared to placebo (p < 0.001). Additionally, LV-VIT C had significantly higher Cmax (plasma + 27%, leukocytes + 20%, p < 0.001) and AUC_0 - 24 (plasma + 21%, leukocytes + 8%, p < 0.001) values as compared to VIT C.</p><p><strong>Conclusion: </strong>Liposomal formulation of vitamin C increases absorption into plasma and leukocytes.</p><p><strong>Trial registration: </strong>Clinical Trials Registry - India (CTRI/2023/04/051789).</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"3037-3046"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11519160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food-sourced guanidinoacetic acid and methylation cycle biomarkers in individuals aged one year and older: a population-based cross-sectional study.","authors":"Sergej M Ostojic, Jelena Cvejic","doi":"10.1007/s00394-024-03493-w","DOIUrl":"10.1007/s00394-024-03493-w","url":null,"abstract":"<p><strong>Purpose: </strong>Several preliminary studies suggest dietary guanidinoacetic acid (GAA) might impact methyl group availability and/or methylation biomarkers, fueling ongoing debates. This study aimed to explore the relationship between dietary GAA intake and plasma indicators of the methylation cycle in individuals aged one year and older, using data from the 2001-2002 National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>Dietary information was obtained from individuals who completed a 24-hour Dietary Recall, with total daily intake of GAA calculated by aggregating all relevant food items. Relevant variables related to the methylation cycle, such as red blood cell (RBC) folate and serum folate, vitamin B12, total homocysteine (tHCy), and methylmalonic acid (MMA), were identified from the NHANES 2001-2002 laboratory assessments.</p><p><strong>Results: </strong>A total of 9,115 individuals (51.3% females) were included in the final analysis. Linear regression unveiled a significant association between higher GAA intake and diminished RBC folate (p < 0.001), serum folate (p < 0.001), and MMA levels (p = 0.007). It also revealed an elevation in tHCy levels with increased GAA intake (p < 0.001). These associations remained significant even after adjusting for demographic variables and dietary factors pertinent to the methylation cycle (p < 0.05).</p><p><strong>Conclusion: </strong>Our findings suggest that dietary exposure to GAA (resulting in conversion to creatine) could be considered a nutritional factor associated with the consumption of methyl groups in the general population.</p>","PeriodicalId":12030,"journal":{"name":"European Journal of Nutrition","volume":" ","pages":"3113-3118"},"PeriodicalIF":4.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}