European Journal of Dentistry最新文献

{"title":"Influence of Occlusal Cusp Inclination and Restoration Thickness on the Biomechanical Performance of Lithium Disilicate Molar Endocrowns: A 3D Finite Element Analysis.","authors":"Layla Hassouneh, Nawar Naguib Nawar, Mohammad Atieh, Dilek Yigit, Venkateshbabu Nagendrababu, Ove A Peters, Manal Matoug-Elwerfelli","doi":"10.1055/s-0045-1810442","DOIUrl":"https://doi.org/10.1055/s-0045-1810442","url":null,"abstract":"<p><p>This study used finite element analysis to investigate the effect of occlusal cusp inclination and restoration thickness of endocrowns on the stress distribution and biomechanical performance.A total of six models of a mandibular first molar representing two different heights of remaining tooth structure above the cemento-enamel junction (1.5 and 3 mm), each with three different buccal cusps inclination angles (original, 10 degrees, and 20 degrees increase in cusp inclination angles) were generated. Models were designated as: 1.5/original, 1.5/10 degrees, 1.5/20 degrees, 3/original, 3/10 degrees, and 3/20 degrees. All models were subjected to an oblique load of 400 N. The maximum principal stress (MPS), maximum shear stress (MSS) at the cement interface, and factor of safety (FoS) were calculated.Increasing the cuspal inclination by 10 degrees in models with a 1.5-mm remaining tooth structure, resulted in a 20% reduction of the MPS in the dentine (27.2 MPa), in comparison with original cuspal inclines (33.9 MPa). However, increasing the cusp inclination in model 1.5/20 degrees resulted in a comparable dentinal stress reduction (17%, 28 MPa) accompanied with an increase in the MSS at the cement interfaces (26.8 MPa), in comparison with 1.5/original (18 MPa). On the other hand, increasing the cusp inclination angle in models 3/10 degrees and 3/20 degrees led to a reduction in MPS within the dentine by 1 and 2%, respectively, while causing an increase in the MSS at the cement interfaces (16.4 and 16.0 MPa, respectively), in comparison with 3/original (11 MPa). Models 1.5/original and 3/original reported the minimum FoS values (3.10 and 3.38, respectively), while model 1.5/10 degrees reported the highest FoS value (3.86).Within the limitations of the current study, cusp inclination adjustments up to 10 degrees may enhance stress distribution in endocrown-restored molars with limited coronal structure.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Fit of Three Commonly Used Veneers for Smile Enhancement: An In Vitro Study.","authors":"Vinod Bandela, Shital Sonune, Ram Basany, Bharathi Munagapati, Saif Faruqi, Saraswathi Kanaparthi, Reef Basher Saad Alkayid, Wroud Alturqi Alshammari, Alreem Abdulaziz Alnuman, Eatedal Mukhlef Alruwaili, Miad Abdulnasser Alahmed, Almas Bassam Aljoufi, Haya Abdulrahman Alrayes, Munirah Saleh Alabid, Doaa Abdelaziz A Helal","doi":"10.1055/s-0045-1810443","DOIUrl":"https://doi.org/10.1055/s-0045-1810443","url":null,"abstract":"<p><p>The objective of the present study was to evaluate the marginal fit of three most commonly used veneers in dentistry.A maxillary central incisor was embedded in a self-cure acrylic resin block, with the crown and 2 mm of the root exposed to facilitate standardized tooth preparation. Following the preparation, 30 elastomeric impressions were made to produce master casts. These working dies were then randomly allocated to three experimental groups, each consisting of 15 samples. Group I comprised indirect composite veneers (ICV), fabricated using laboratory composite resin. Group II included pressable ceramic veneers (PCV), manufactured using heat-pressed lithium disilicate. Group III consisted of computer-aided designing (CAD)/computer-aided manufacturing (CAM) ceramic veneers, fabricated through digital milling of lithium disilicate blocks. All veneers were fabricated in accordance with the respective manufacturer's guidelines and were carefully repositioned on the prepared tooth to evaluate the marginal discrepancy using a stereomicroscope.Three pre-designated points-mesio-labial, mid-labial, and disto-labial and mesio-palatal, mid-palatal, and disto-palatal on the labial and palatal margins-were measured. The values were recorded and analyzed with one-way ANOVA and Tukey's post-hoc test using SPSS software.ICV showed more variation with mean discrepancy of 189.24 ± 25.17 µm at cervical margin and 79.01 ± 11.68 µm at palatal area. PCV showed less variation with mean discrepancy of 48.2 ± 8.35 µm and 40.58 ± 9.47 µm at cervical and palatal areas, respectively. CAD/CAM-fabricated ceramic veneers showed mean discrepancy of 94.24 ± 9.00 µm at cervical and 52.72 ± 16.33 µm at palatal areas.Pressable ceramic veneers showed the best marginal fit at both cervical and palatal margins followed by CAD/CAM veneers. Indirect composite veneers showed poorest marginal fit. The marginal discrepancy values were within the clinically acceptable range for PCV and CAD/CAM ceramic veneers.It is of paramount importance that the dentist should choose wisely the veneer material taking the marginal fit into account.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Mandibulofacial Asymmetry and Temporomandibular Disorder Using Diagnostic Criteria for Temporomandibular Disorder (DC/TMD).","authors":"Agia T Andriani, Maria Purbiati, Krisnawati, Ira Tanti","doi":"10.1055/s-0045-1809698","DOIUrl":"https://doi.org/10.1055/s-0045-1809698","url":null,"abstract":"<p><p>Mandibulofacial asymmetry can cause disharmony in facial appearance and smile and may also impair stomatognathic function and speech ability, negatively affecting psychological well-being and quality of life. This condition is also commonly associated with temporomandibular disorders (TMDs). This study aimed to analyze the relationship between mandibulofacial asymmetry and TMDs.This study conducted a cross-sectional study involving 42 patients (14 males and 28 females) aged 17 to 45 years. The diagnosis of TMDs was made using the Diagnostic Criteria for Temporomandibular Disorders, and facial asymmetry was assessed using frontal photography.The results showed that 76.2% of the patients with mandibulofacial asymmetry had a TMD. Statistical tests showed a relationship between mandibulofacial asymmetry and TMDs (<i>p</i>-value < 0.05).The TMD is closely related to mandibulofacial asymmetry. However, the relationship between mandibulofacial asymmetry and the specific categories of TMDs was not statistically significant, as determined by multinomial regression analysis.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Vessel, VEGF, and FGF Expression in Traumatic Ulcer Healing of Wister Rats after Application of Chitosan-Aloe vera Gel.","authors":"Sularsih Sularsih, Yasmin Nabila Athaya, Fitria Rahmitasari, Dwi Setianingtyas, Nur Tsurayya Priambodo, Wibi Riawan","doi":"10.1055/s-0045-1810118","DOIUrl":"https://doi.org/10.1055/s-0045-1810118","url":null,"abstract":"<p><p>The purpose of this study was to analyze the application of chitosan (CH)-<i>Aloe vera</i> (AV) gel on blood vessels, vascular endothelial growth factor (VEGF), and fibroblast growth factor (FGF) expression in traumatic ulcer healing.Chitosan powder with deacetylation degree of 93% dissolved in 2% acetic acid, neutralized with NaOH solution, and combined with AV gel. Traumatic ulcers were made with a 4-mm diameter along the lower labial mucosa of Wistar rats using a heated burnisher. Negative control group (KA) was treated with placebo, positive control group (KB) using 0.2% hyaluronic acid, treatment group using chitosan (CH) gel (PA) and AV gel (PB), and group using combination CH-AV gel (PC). The blood vessel numbers were analyzed with hematoxylin eosin staining and the expression of VEGF and FGF were analyzed using immunohistochemistry on days 3 and 7.One-way analysis of variance was conducted to analyze the difference between groups and the Tukey honestly significant difference multiple comparisons test was used to analyze different pairs of groups (<i>p</i> < 0.05).Blood vessels, VEGF, and FGF expression were higher in the treatment group using combination CH-AV gel on days 3 and 7 compared with the control group and treatment group using CH or AV gel (<i>p</i> < 0.05).The application of CH-AV gel increased the number of blood vessels, VEGF, and FGF expression in traumatic ulcer healing of Wistar rats.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingival Blood Vessels in Smokers and Nonsmokers: A Scoping Review.","authors":"Aura Hemalinda Adelia, Siti Sopiatin, Amaliya Amaliya","doi":"10.1055/s-0045-1809913","DOIUrl":"https://doi.org/10.1055/s-0045-1809913","url":null,"abstract":"<p><p>Smoking is an independent risk factor for periodontal disease. Despite the severity of periodontal disease, smokers demonstrated reduced clinical signs of inflammation in gingivitis and periodontitis. The present review analyzed the gingival blood vessels between smokers and nonsmokers to obtain a more comprehensive overview. A scoping review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Review guidelines, according to the inclusion and exclusion criteria that have been set. Articles were retrieved from five databases: PubMed, Web of Science, EBSCOhost, Scopus, and ScienceDirect. The article searches were performed using keywords ((smoke OR smoking) AND (gingival vessel OR gingival vascular OR gingival microvasculature OR gingival vascularity OR gingival blood vessel OR gingival flow)). From an initial pool of 217 articles, 10 were ultimately chosen for detailed analysis. This selection encompassed seven cross-sectional studies, two case-control studies, and one experimental study. According to the articles that have been reviewed, there were differences in gingival blood vessel density between smokers and nonsmokers in different periodontal conditions, namely, healthy periodontal tissue, gingivitis, and periodontitis. The differences were more pronounced when smokers had gingivitis and periodontitis compared with nonsmokers with the same diseases. Assessment of blood vessel distribution showed that small and medium-sized vessels were more prevalent in smokers, while large vessels were more common in nonsmokers. Additionally, the lumen of blood vessels in smokers was narrower compared with nonsmokers.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Potential of aMMP-8 PoCT in Oral Fluids: Insights from Periodontitis and Metabolic Syndrome Interplay.","authors":"Julie Toby Thomas, Betsy Joseph, Timo Sorsa, Sukumaran Anil, Tuomas Waltimo","doi":"10.1055/s-0045-1809977","DOIUrl":"https://doi.org/10.1055/s-0045-1809977","url":null,"abstract":"<p><p>This study evaluated the expression of active-matrix metalloproteinase-8 (aMMP-8) in saliva, oral rinse, and gingival crevicular fluid (GCF) of periodontitis patients with and without metabolic syndrome (MetS) and assessed correlations between aMMP-8 levels and both periodontal and metabolic parameters.One hundred and twenty participants aged 25 to 55 years were classified into three groups: MetS with periodontitis (MetS-PD, <i>n</i> = 40); systemically healthy with periodontitis (SH-PD, <i>n</i> = 40); and systemically and periodontally healthy controls (SH-PH, <i>n</i> = 40).The median age of the participants was 49.5 ± 8.94 in MetS-PD, 47.5 ± 5.6 in SH-PD, and 42.5 ± 11.14 in SH-PH. Systemic parameters (waist circumference, blood pressure, lipid profile, and glycemic indices) and periodontal parameters (bleeding on probing, plaque score, probing depth, and clinical attachment loss) were assessed. aMMP-8 was evaluated qualitatively using point-of-care testing (PoCT) and quantitatively via ELISA in oral rinse, saliva, and GCF.The PoCT was positive in 90% of MetS-PD and 85% of SH-PD participants, while all SH-PH participants tested negative (<i>p</i> < 0.01). MetS-PD exhibited significantly higher aMMP-8 levels in oral rinse and saliva than SH-PD (<i>p</i> = 0.001), whereas GCF aMMP-8 levels were higher in SH-PD but not substantially different from MetS-PD (<i>p</i> = 0.086). Strong positive correlations were observed between aMMP-8 levels in all oral matrices and periodontal parameters (<i>p</i> < 0.001). Among metabolic parameters, waist circumference, triglycerides, low-density lipoprotein, and fasting blood sugar showed stronger correlations with aMMP-8 levels than blood pressure measurements.The aMMP-8 PoCT effectively distinguished periodontally diseased individuals from healthy controls. Elevated aMMP-8 levels (>20 ng/mL) in oral fluids, especially saliva and oral rinse, were significantly associated with both periodontal and systemic risk factors, supporting the potential of aMMP-8 as a noninvasive biomarker for periodontitis and metabolic disorders.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Value of Beclin-1 and HIF-1α in Oral Squamous Cell Carcinoma.","authors":"Nadia Attia Radi, Doaa Adel Habba, Seham Ibrahim Hallool, Sulaiman Saeed Alqahtani, Hanaa Mohamed Abd Elsamia","doi":"10.1055/s-0045-1806930","DOIUrl":"https://doi.org/10.1055/s-0045-1806930","url":null,"abstract":"<p><strong>Objectives: </strong> Certain factors that disturb the tumor microenvironment influence the promotion of tumorigenesis. Detecting gene expression at the protein level is highly valuable and complements the histopathological analysis achieved by immunohistochemistry (IHC). Hypoxia-inducible factor (HIF)-1α accomplishes autophagy induction and regulation of autophagy-associated genes. So, this study was carried out to evaluate the tissue protein expression of Beclin-1 and HIF-1α using IHC and correlate their expression with the prognosis of oral squamous cell carcinoma (OSCC).</p><p><strong>Materials and methods: </strong> Immunohistochemical evaluation of Beclin-1 and HIF-1α was done in 5 samples of normal oral epithelial tissues and 45 samples of OSCC, which were classified histologically into 15 samples each of well, moderately, and poorly differentiated squamous cell carcinoma.</p><p><strong>Results: </strong> According to statistics, normal tissue had the highest values for Beclin-1, while poorly differentiated OSCC had the lowest mean area percentage. HIF-1α showed the opposite results. These results indicate that the association of both molecules has a greater role in the transformation from normal to different histopathological grades of OSCC.</p><p><strong>Conclusion: </strong> The close association between Beclin-1 and HIF-1α identified in the current study confirms hypoxia's critical role in autophagy activation. Moreover, reduced Beclin-1 and elevated HIF-1α expression were significantly associated with the histopathological grading of OSCC, supporting their pivotal role in the development and progression of OSCC.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Titanium Nitride Thin Film on Titanium Using Cathodic Arc Plasma Evaporation for Biomedical Application.","authors":"Trung Van Trinh, Hung Thai Le, Bang Le Thi","doi":"10.1055/s-0045-1810016","DOIUrl":"https://doi.org/10.1055/s-0045-1810016","url":null,"abstract":"<p><p>Commercially pure titanium (Cp-Ti) is often used for biomedical implant devices but has low hardness and wear resistance; therefore, it is not suitable for use in the sliding parts or joints. Owing to their good wear resistance and biocompatibility, titanium nitride (TiN) coatings are used to improve these surface properties of Ti. This study aims to fabricate TiN on Cp-Ti by cathodic arc plasma evaporation and to investigate the effect of Cp-Ti substrate temperature on the properties of coated TiN thin films for biomedical applications.Coated TiN thin films were deposited on Cp-Ti at different substrate temperatures of 25, 100, 175, and 250°C. The surface morphology, roughness, phase composition, hardness, coating adhesion, and biocompatibility of the TiN coatings were investigated using a digital optical microscope, scanning electron microscope, X-ray diffractometer, hardness tester, and <i>in vitro</i> cell studies.Statistical differences were evaluated using analysis of variance (ANOVA) and Tukey's multiple comparison analysis, with statistical significance set at <i>p</i> < 0.05.Thin films with a primary TiN phase were formed on the surface of the Cp-Ti substrate regardless of substrate temperatures. There was no significant difference in surface hardness between the coated samples even though the sample coated at 100 and 175°C showed a slightly higher values, ranging from 193 to 199 HV. Interestingly, surface roughness and coating adhesion were significantly influenced by substrate temperature. The higher the substrate temperature, the greater the surface roughness, while the best adhesion, with the hardness of 176 HV, was obtained at substrate temperature of 25°C. <i>In vitro</i> cell study indicated that the baby hamster kidney cells on the coating surface have grown and proliferated better than those on the uncoated surface.The TiN thin film was successfully coated on Ti by cathodic arc plasma evaporation at different substrate temperatures, ranging from 25 to 250°C. The adhesion of the coating at low substrate temperature (25°C) was the best compared to other substrate temperatures of 100, 175, and 250°C. <i>In vitro</i> cell studies have demonstrated the biocompatibility of the coated TiN thin film.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanical and Biological Properties of Nondecellularized Human Wharton's Jelly Matrix for Soft Tissue Graft Material: An In Vitro Study.","authors":"Mefina Kuntjoro, Nike Hendrijantini, Eric Priyo Prasetyo, Nurani Atikasari, Made Shintya Danaswari, Guang Hong","doi":"10.1055/s-0045-1809981","DOIUrl":"https://doi.org/10.1055/s-0045-1809981","url":null,"abstract":"<p><p>This study aims to determine the mechanical properties of hWJM through ultimate tensile strength (UTS) and elastic modulus tests, degradation, and porosity tests. Additionally, it evaluates the biological properties of hWJM by assessing growth factor secretion (fibroblast growth factor-2 [FGF-2] and vascular endothelial growth factor-A [VEGF-A]).For the mechanical tests, two groups were analyzed: group 1 was tested in a wet condition and group 2 in a dry condition. Degradation tests were conducted using phosphate buffer saline (PBS), collagenase enzyme, and simulated body fluid (SBF). The porosity test was conducted using a scanning electron microscope (SEM). For the biological tests, two groups were analyzed: group 1 consisted of nondecellularized hWJM and group 2 of human umbilical cord mesenchymal stem cells. All the data were collected and analyzed statistically.The mean ± standard deviation of the UTS test for group 1 was 0.787 ± 0.356 MPa, while for group 2, it was 1.897 ± 0.582 MPa. The elastic modulus test results were 0.568 ± 0.206 MPa for group 1 and 6.354 ± 2.985 MPa for group 2. The result showed that PBS degradation was 22% on day 14 and 39% on day 28. The collagenase enzyme degraded 15% after 1 hour, 63% after 6 hours, and 74% after 24 hours. SBF degradation rates were 10.3% after 1 week, 10.5% after 2 weeks, 12.5% after 4 weeks, and 13.9% after 8 weeks. The porosity test results showed an average pore size of 66.95 μm. For the biological tests, no significant differences in FGF-2 and VEGF secretion were observed between groups, with the highest secretion in group 1 occurring on day 7.Nondecellularized hWJM has been shown to meet the physical, mechanical, and biological criteria for soft tissue graft in dentistry.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Linking Salivary Calbindin-D28k to Oral Health Outcomes in Chronic Kidney Disease.","authors":"Mohamed Abdullah Jaber, Alexander Maniangat Luke, Mohamed Saleh Hamad Ingafou, Nireeksha Nireeksha","doi":"10.1055/s-0045-1809976","DOIUrl":"https://doi.org/10.1055/s-0045-1809976","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a universal health concern, with CBD- 28k (calbindin-D28k) being 1 alpha, 25-dihydroxyvitamin D3-dependent calcium-binding protein, playing a role in kidney function. Renal dialysis may alter calbindin-D28k levels, impacting oral health and periodontal health. Understanding these impacts is crucial for managing CKD. This study aimed to explore the potential of salivary calbindin-D28k as a predictor of oral health in subjects with CKD.This case-control study involved 200 individuals aged 24 to 77 years, out of which 100 were undergoing CKD treatment. Biochemical parameters were recorded, and unstimulated saliva samples were collected. Decayed, Missing and Filled Teeth and periodontal scores were noted after clinical examination. Salivary calbindin-D28k level was estimated by immunosorbent assay (enzyme-linked immunosorbent assay). A two-tailed test of <i>p</i>-value of < 0.05 was used to determine statistics.Demographic parameters showed a significant age and gender difference between the groups. Significant variation in the level of hematological and biochemical parameters between the groups was observed. Renal function test and liver function test levels varied significantly in CKD patients. Notable difference in the level of salivary calbindin-D28k levels and periodontal scores revealed poor oral health. The best cutoff value for calbindin-D28k was obtained from the receiver operating characteristic curve indicating a risk of poor oral health in CKD subjects. Additionally, salivary calbindin-D28k levels and oral health showed significant association and correlation.The current research findings suggest that monitoring salivary calbindin-D28k levels could serve as an important predictor of oral health in CKD subjects highlighting the importance of complete oral health management in subjects with CKD.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}