{"title":"Evaluating the Efficacy of Resveratrol-Containing Mouthwash as an Adjunct Treatment for Periodontitis: A Randomized Clinical Trial.","authors":"Sura A Mohammed, Hadeel Mazin Akram","doi":"10.1055/s-0044-1788686","DOIUrl":"10.1055/s-0044-1788686","url":null,"abstract":"<p><strong>Objectives: </strong> To evaluate the effectiveness of resveratrol mouthwash as an adjunct to nonsurgical periodontal treatment of periodontitis.</p><p><strong>Materials and methods: </strong> This study was a randomized, double-blind clinical trial study. The study included 57 participants with periodontitis. Clinical parameters (plaque index [PI], bleeding on probing [BOP], probing pocket depth [PPD], and clinical attachment loss [CAL]) were examined at the baseline visit, after 7 days, and after 30 days of using resveratrol mouthwash as an adjunct to nonsurgical periodontal treatment. The salivary levels of (interleukin [IL]-6) and RANKL (receptor activator of nuclear factor-kappa B ligand) were measured and compared before and after treatment. The participants answered the visual analog scale-based assessment questionnaire at the last visit.</p><p><strong>Statistical analysis: </strong> A one-way ANOVA (analysis of variance) test was used to compare the means of multiple groups (test, positive control, negative control) at baseline and after treatment. A paired <i>t</i>-test was also used to compare the means of a single group before and after treatment. In addition, Tukey's multiple comparisons test was used to identify specific pairwise differences between the three groups after finding significant differences with ANOVA. The Chi-square test was also used to compare the distribution of categorical variables like sex between the groups.</p><p><strong>Results: </strong> All interventions significantly reduced PI, BOP, PPD, and CAL, but resveratrol and chlorhexidine had a higher significant effect than placebo except for CAL without a significant difference between them. All mouthwashes significantly reduced the salivary concentration of IL-6. However, resveratrol and chlorhexidine had a significantly higher effect than placebo, while the concentration of RANKL was decreased in all groups without a significant difference between them. The participants' responses to the mouthwash questionnaire showed that resveratrol and chlorhexidine had the same feedback without significant differences.</p><p><strong>Conclusion: </strong> Resveratrol-containing mouthwash could be used as an alternative to chlorhexidine as an adjunct to nonsurgical periodontal treatment of periodontitis.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"354-365"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tarek Ahmed Soliman, Ali Robaian, Nasser Raqe Alqhtani, Abdullah Alshehri, Abdullah Saad Alqahtahni, Ibrahim Saleh Aljulayfi, Magdy Alazzazi, Ali Elkaffas, Shahad Saleh AlGhannam, Sayed Ghorab
{"title":"Debonding Characteristic and Survival Probability of Adhesive Flash-Free Ceramic Orthodontic Brackets Following pH Cycling.","authors":"Tarek Ahmed Soliman, Ali Robaian, Nasser Raqe Alqhtani, Abdullah Alshehri, Abdullah Saad Alqahtahni, Ibrahim Saleh Aljulayfi, Magdy Alazzazi, Ali Elkaffas, Shahad Saleh AlGhannam, Sayed Ghorab","doi":"10.1055/s-0044-1795125","DOIUrl":"10.1055/s-0044-1795125","url":null,"abstract":"<p><strong>Objectives: </strong> Orthodontic bracket bond failure is an obstacle in clinical orthodontics. This study investigated the influence of pH cycling on the shear bond strength (SBS), adhesive remnant index (ARI), and survival probability of adhesive-precoated flash-free ceramic brackets.</p><p><strong>Materials and methods: </strong> Forty mandibular premolars were randomly divided into two groups (<i>n</i> = 20): C: noncoated orthodontic brackets, and F: flash-free adhesive-precoated orthodontic brackets. Each group was subdivided into two subgroups according to storage medium solutions (<i>n</i> = 10): in subgroup AS, specimens were immersed in artificial saliva for 24 hours, and in Subgroup ASL, specimens were recycled between a demineralizing solution and an artificial saliva for 42 days. Within each subgroup, specimens were subjected to SBS and ARI testing. SBS data were analyzed using one-way ANOVA (analysis of variance) and Tukey's post-hoc test. Weibull analysis was performed on the SBS data to determine the characteristic SBS and their survival probabilities.</p><p><strong>Results: </strong> Flash-free adhesive-precoated brackets had higher significant (<i>p</i> < 0.001) SBS values in both the AS group (17.74 ± 1.74 MPa) and the ASL group (12.61 ± 1.40 MPa) compared with the noncoated bracket (10.67 ± 1.55 and 7.89 ± 1.39 MPa, respectively). The ARI scores for the noncoated brackets in the AS group were 70% occurrence for score 1, while 90% for score 1 in the ASL group. For the flash-free precoated brackets, ARI scores were 70% occurrence for score 2 in the AS group, while 80% for score 2 in the ASL group. Flash-free brackets had higher SBS in both AS and ASL groups (14.07 and 9.76 MPa, respectively), at 95% survival probability.</p><p><strong>Conclusion: </strong> Flash-free orthodontic brackets performed better in terms of significantly higher bond strength and higher ARI scores. Meanwhile, noncoated brackets revealed acceptable SBS results in both storage medium groups. Flash-free brackets showed higher survival than the noncoated brackets in both storage medium groups at 90% survival probability.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"449-456"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Impact of Silver Diamine Fluoride and Potassium Iodide Treatment on Microtensile Bonds Strength of Composite Restoration for Carious Dentin in Primary and Permanent Teeth and Its Potential Color Changes: An In Vitro Study.","authors":"Sarah D Shaheen, Doaa A M Esmaeil, Somaia Ghobar","doi":"10.1055/s-0044-1791684","DOIUrl":"10.1055/s-0044-1791684","url":null,"abstract":"<p><strong>Objectives: </strong> This study aims to examine the effects of silver diamine fluoride and potassium iodide (SDF/KI) treatment on the possible color changes and the microtensile bond strength of composite restorations to carious dentin in different dentitions.</p><p><strong>Material and methods: </strong> A total of 48 sound human teeth were utilized in this study. Twenty-four primary molar teeth were divided into two groups. Each group has 12 teeth; group 1 received no pretreatment, while group 2 received SDF/KI treatment. Also, 24 permanent premolar teeth were divided into two groups. Group 3 received no pretreatment, and group 4 received SDF/KI treatment. For 7 days at 25 °C, every sample was submerged in a demineralizing solution. Following the manufacturer's guidelines for SDF/KI treatments, exposed dentin surfaces were promptly preserved in artificial saliva (pH 7.4) for 14 days. On the prepared teeth surfaces of the nontreated groups, deionized water was administered rather than SDF/KI. A self-etching bonding agent was used, and a 4-mm-thick composite restoration was constructed. Evaluations were conducted on color measurement, microtensile bond strength, and mode of failure.</p><p><strong>Statistical analysis: </strong> The groups were compared using a one-way analysis of variance test, and a post hoc test was used for pairwise comparisons.</p><p><strong>Result: </strong> Regarding color measurement, in deciduous dentition, there were no statistically significant differences between the groups. Additionally, there is no discernible variation in Δ<i>E</i> values among various pretreatment groups in the permanent dentition. Microtensile bond strength did not differ significantly between permanent and deciduous teeth.</p><p><strong>Conclusion: </strong> A 14-day delay in the application of composite restoration can successfully conceal the color of SDF/KI without compromising the microtensile bond strength.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"493-499"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bushra Jabeen, Zulfiqar A Mirani, Muneeb A Lone, Arpit Nirkhiwale, Waqas A Farooqui, Kashif Aslam, Muhammad Adeel Ahmed, Fahim Vohra
{"title":"Comparison of Chlorhexidine Gluconate, Sodium Hypochlorite, Neem Extract, and Microwave Radiation for Disinfection of Type IV Dental Stone.","authors":"Bushra Jabeen, Zulfiqar A Mirani, Muneeb A Lone, Arpit Nirkhiwale, Waqas A Farooqui, Kashif Aslam, Muhammad Adeel Ahmed, Fahim Vohra","doi":"10.1055/s-0044-1788631","DOIUrl":"10.1055/s-0044-1788631","url":null,"abstract":"<p><strong>Objective: </strong> The present study evaluated the effect of chemical disinfectants and microwave sterilization on the removal of biofilm containing <i>Pseudomonas aeruginosa</i>, <i>Streptococcus mutans</i>, and <i>Candida albicans</i> from type IV dental stone.</p><p><strong>Materials and methods: </strong> One hundred twenty-eight (<i>N</i> = 128) type IV dental cast stone specimens were prepared, and biofilms of microorganisms were cultured. Dental stone samples were subjected to disinfection protocols, including 0.5% chlorhexidine (CHX), 0.5% sodium hypochlorite (NaOCl), 20% neem extract, and microwave irradiation for 1 to 5 minutes. Colony forming unit (CFU) counts and scanning electron microscopy were utilized to witness changes in the biofilm, pre- and postdisinfection/sterilization.</p><p><strong>Results: </strong> For <i>P. aeruginosa</i>, significant (<i>p</i> < 0.05) decrease in CFU counts after 1 minute (from 233 to -215) and 2, 3, and 5 minutes (from 233 to -233) were observed after CHX treatment. After microwave radiation, a significant decrease in CFU counts was also observed after 1 minute (from 233 to -130.3), 2 minutes (from 233 to -229), and 3 and 5 minutes (from 233 to -233). For <i>S. mutans</i>, a significant (<i>p</i> < 0.05) decrease in CFU counts was observed after 1, 2, 3, and 5 minutes (from 212 to -268) after NaOCl treatment and microwave radiation (from 212 to -271 after 1 minute and from 212 to -274.3 after 2, 3, and 5 minutes). For <i>C. albicans</i>, significant (<i>p</i> < 0.05) decrease in the CFU counts (1-5 minutes) was observed after CHX exposure, while NaOCl and microwave radiation demonstrated equal disinfection potency. Neem extract was effective to disinfect the dental stone; however, it was not as potent as the other disinfectants and microwave radiation.</p><p><strong>Conclusion: </strong> It was observed that exposure to CHX, NaOCl, and microwave radiation significantly reduced the microbial CFU counts. Although the use of neem extract also significantly reduced these CFU counts, this reduction was not as much as the other three tested materials. Further research exploring other chemical disinfectants with various concentrations is recommended.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"346-353"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020589/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Patera Nugraha, Delfia Amanda Putri, Andree Salim, Ida Bagus Narmada, Ari Triwardhani, I Gusti Aju Wahju Ardani, Alida Alida, Adya Pramusita, Tengku Natasha Eleena Binti Tengku Ahmad Noor
{"title":"Arch Length Discrepancy Analysis Comparison with the Huckaba and Moyers Method in Angle Class I Malocclusion in Surabayan Children with Mixed Dentition during the Growth and Development Phase: A Retrospective Cross-Sectional Study in Universitas Airlangga Dental Hospital.","authors":"Alexander Patera Nugraha, Delfia Amanda Putri, Andree Salim, Ida Bagus Narmada, Ari Triwardhani, I Gusti Aju Wahju Ardani, Alida Alida, Adya Pramusita, Tengku Natasha Eleena Binti Tengku Ahmad Noor","doi":"10.1055/s-0045-1807732","DOIUrl":"https://doi.org/10.1055/s-0045-1807732","url":null,"abstract":"<p><p>The aim of the study was to compare the ALD results obtained using the Huckaba and Moyers methods, including the segmentation and brass wire techniques, in class I Angle malocclusion in Surabayan children during the MD and GDP at Dental Hospital Universitas Airlangga.This study adopted a retrospective cross-sectional design, involving a total of 252 samples. However, only 32 samples that met the inclusion criteria were analyzed for ALD by using the Huckaba and Moyers methods. Sex, chronological age, and malocclusion angle classification were recorded. Cervical maturation vertebrae stage was conducted to determine the skeletal age, while dental age was investigated through the Demirjian method in the GDP during MD in Javanese children. Lateral cephalogram was examined to determine skeletal malocclusion based on the Steiner analysis (Sella-Nasion-A [<SNA], Sella, Nasion, B [<SNB], [SNA-SNB] <ANB).The Shapiro-Wilk and Levene tests revealed nonnormal distribution and lack of homogeneity, leading to the use of nonparametric Kruskal-Wallis and Mann-Whitney U tests for identifying significant differences.In the upper and jaw, the Moyers method demonstrated a positive ALD value, whereas the Huckaba method exhibited a negative ALD value, indicating a significant difference between the groups.Discrepancy analysis revealed significant differences between the Huckaba and Moyers methods for class I Angle malocclusion in Surabayan children during MD and GDP at Dental Hospital Universitas Airlangga.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huda Abutayyem, Mohammad Khursheed Alam, Maher Al Shayeb, Raghad Hashim
{"title":"A Systematic Review and Meta-Analysis of the Prevalence of Dental Caries in the Permanent Teeth of Arab Children.","authors":"Huda Abutayyem, Mohammad Khursheed Alam, Maher Al Shayeb, Raghad Hashim","doi":"10.1055/s-0044-1795117","DOIUrl":"10.1055/s-0044-1795117","url":null,"abstract":"<p><p>Despite the global prevalence of dental caries, there is a paucity of comprehensive data on the extent of this issue among children in the Arab region. This systematic review and meta-analysis aimed to evaluate the prevalence of dental caries and the associated Decayed, Missing, and Filled Teeth (DMFT) indices in permanent teeth among children from 4 to under 18 years of age in the Arab region. A comprehensive review of various studies was conducted. Studies were searched across eight different electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. The random effects (RE) model was used for analysis, allowing variation in effect sizes across studies.The RE model suggested a high caries prevalence rate of 72.62% (with a 95% confidence interval of 65.3%-78.89%), suggesting a large burden of dental caries in this population pertaining to permanent teeth. The <i>I</i> <sup>2</sup> score was 99.0%, showing high heterogeneity among the investigations. The mean DMFT score was found to be 1.675 (with a 95% confidence interval of 0.5519-2.7980), indicating of substantial dental health concerns. Surprisingly, the <i>I</i> <sup>2</sup> value for DMFT scores was 0.0%, demonstrating no detected heterogeneity among the trials. The study highlights a high prevalence of dental caries and significant DMFT scores among children in the Arab region, signaling an urgent public health concern. The lack of heterogeneity in DMFT scores across studies, despite high caries prevalence, suggests potential limitations in the DMFT indices' ability to capture the full severity of dental caries. Further research is needed to refine these tools and fully understand the burden of dental caries in this population.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"275-285"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Samad Khan, Ahlam AlAbdali, Nadia Irshad, Othoob AlMusayyab, Norah AlQahtani, Asma Tufail Shah, Sultan Akhtar, Yassine Slimani
{"title":"Evaluation of Mechanical and Elemental Properties of Bioceramic-Coated Orthodontic Brackets and Enamel Surface.","authors":"Abdul Samad Khan, Ahlam AlAbdali, Nadia Irshad, Othoob AlMusayyab, Norah AlQahtani, Asma Tufail Shah, Sultan Akhtar, Yassine Slimani","doi":"10.1055/s-0044-1789003","DOIUrl":"10.1055/s-0044-1789003","url":null,"abstract":"<p><strong>Objective: </strong> The aim is to coat orthodontic brackets with two different bioactive materials and to compare the mechanical and morphological properties of coated brackets and tooth surfaces.</p><p><strong>Materials and methods: </strong> A total of 120 stainless steel brackets were divided equally into three groups, that is, the uncoated brackets and nanohydroxyapatite (nHA)-coated, and nanobioactive glass (nBG)-coated brackets using a spin coater machine. The brackets were bonded on the enamel surface and underwent remineralization/demineralization cycles for days 1, 7, 14, and 30. At each time interval, the bond strength of the brackets was assessed using mechanical loading. An optical and scanning electron microscope (SEM) were used for surface evaluation, and the adhesive remanent index (ARI) values were obtained and quantified.</p><p><strong>Statistical analysis: </strong> One-way analysis of variance using Tukey's test was used to compare the differences among the groups.</p><p><strong>Results: </strong> A uniform distribution of nanoparticles occurred on the surfaces of brackets. The shear bond strength (SBS) showed no significant differences in any tested groups on days 1, 7, and 14. However, control and nBG showed a significant difference from nHA at day 30. On days 7, 14, and 30, the nHA group showed the highest SBS values among the groups. For ARI, most samples showed an adhesive nature of failure at the enamel-brackets interface. The images confirmed the presence of coated particles on brackets and remnants of adhesives after SBS.</p><p><strong>Conclusion: </strong> This study confirmed that the nHA- and nBG-coated brackets have a high potential for application in orthodontics regarding structural and mechanical properties.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"389-398"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Utilization of Ultrashort Bicon Implants in Clinical Situations: A Retrospective Case Series.","authors":"Damian Dudek, Gregori M Kurtzman, Karpe Jacek, Arkadiusz Badziński, Edyta Reichman-Warmusz","doi":"10.1055/s-0044-1791786","DOIUrl":"10.1055/s-0044-1791786","url":null,"abstract":"<p><p>When vertical bone loss results in insufficient crestal height to place standard-length implants without the use of osseous grafting, this poses clinical issues to implant usage. Based on an analysis of the literature and clinical experience, it has been found that it is possible to optimally use the available bone volume of the maxillary and mandibular ridges for implant placement without extensive osseous grafting to increase vertical height. This case report will examine several uses of ultrashort implants utilizing the Bicon system in common clinical situations in the maxillary and mandibular arches without the need for osseous reconstruction to improve the available vertical height of the crest to permit implant placement.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"544-550"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"YAP Expression is Related to the Aggressive Behavior of Odontogenic Cysts.","authors":"Jutamas Uttagomol, Adjabhak Wongviriya, Ariya Chantaramanee, Thanit Prasitsak","doi":"10.1055/s-0044-1801275","DOIUrl":"https://doi.org/10.1055/s-0044-1801275","url":null,"abstract":"<p><strong>Objective: </strong> Yes-associated protein (YAP) and Ki-67 are known to be involved in cell proliferation. While their overexpression is associated with aggressive behaviors in oral squamous cell carcinoma (OSCC), their roles in odontogenic cysts have not been thoroughly investigated. Therefore, this study aimed to evaluate the immunohistochemical expression of YAP and Ki-67 in odontogenic cysts.</p><p><strong>Material and methods: </strong> Tissue samples included 12 radicular cysts, 10 dentigerous cysts, 9 odontogenic keratocysts, and 9 normal oral mucosa specimens. Immunohistochemical analysis was conducted both manually and using ImageJ software for comparison.</p><p><strong>Statistical analysis: </strong> The Kruskal-Wallis, followed by the Mann-Whitney <i>U</i>-test was used to assess the differences in the YAP and Ki-67 immunoexpression levels among various group lesions. The correlation between those two proteins in individual groups was tested by Spearman correlation. A <i>p</i>-value of less than 0.05 was considered statistically significant. SPSS software version 25.0 was used.</p><p><strong>Results: </strong> There was a strong nuclear staining of YAP in basal and superficial cells and an intense cytoplasmic YAP positivity in odontogenic keratocysts, whereas a weaker YAP staining in both the nucleus and cytoplasm throughout the epithelial thickness was observed in dentigerous cyst, radicular cyst, and normal oral mucosa, respectively. YAP expression differed significantly in all odontogenic cysts compared with normal oral mucosa (<i>p</i> < 0.05). Ki-67 expression was notably higher in odontogenic keratocysts relative to other cysts and normal oral mucosa. Although no statistically significant correlation was found between YAP and Ki-67 across the groups, both proteins displayed similar positive trends in odontogenic keratocysts.</p><p><strong>Conclusion: </strong> These findings suggest that YAP activation may be related to the proliferative behavior of odontogenic cysts, especially in more aggressive lesions, but less likely to influence the inflammatory cysts. This insight could improve understanding of their pathogenesis and pave the way for new diagnostic and therapeutic approaches.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanephume Sripairojn, Niwut Juntavee, Apa Juntavee
{"title":"Comparison of Internal Accuracy of Ceramic Veneered Sintered Metal versus Cast Metal Restoration Upon Different Fabrication Processes.","authors":"Sanephume Sripairojn, Niwut Juntavee, Apa Juntavee","doi":"10.1055/s-0045-1807730","DOIUrl":"https://doi.org/10.1055/s-0045-1807730","url":null,"abstract":"<p><p>One critical factor that influences clinical outcomes of fixed dental restorations is the internal gaps between the restoration and the abutment tooth. However, investigating these gaps in the context of fabrication processes with new technologies is few. This study compared internal accuracy of sintered versus cast metal substructures upon different fabrication techniques, veneered with layering and press-on ceramic, during different construction stages, at different sites of restoration.A total of 96 metal substructures were fabricated with a standardized dimension from four techniques: cast metal with traditionally impressed tooth [CmTt], cast metal with digitally milled wax [CmDw], sintered metal with digitally impressed tooth [SmDt], and sintered metal with digitally impressed stone model [SmDm]. They were further subdivided into two subgroups according to the veneering ceramic used [layered (Pl) and press-on (Pp)]. Internal accuracy was evaluated at gingival, gingiva-axial, axial, axio-occlusal, and occlusal locations using silicone replica, after metal coping (As), degassing (De), opaque application (Op), contouring (Co), and glazing (Gl).Analysis of variance and Bonferroni tests were analyzed for significant differences of internal fit upon different factors (<i>α</i> = 0.05).Significantly different internal accuracy was found upon metal substructures fabrication technique, veneering methods, stages, and sites of restoration (<i>p</i> < 0.05). SmDt and SmDm revealed significantly better fit than CmTt and CmDw (<i>p</i> < 0.05). Pp generated significantly better fit than Pl (<i>p</i> < 0.05). Significantly increasing gaps were found upon stages (<i>p</i> < 0.05). Occlusal and axio-occlusal sites exhibited larger gaps than axial, gingivo-axial, and gingival sites (<i>p</i> < 0.05). However, all groups exhibited clinically acceptable internal accuracy.Increasing internal inaccuracies upon stages of fabrication were noticed, with highly observed at the occlusal and axio-occlusal sites. Sintered metal (SmDt, SmDw) provided better accuracy than cast metal (CmTt, CmDw) while press-on veneering generated better accuracy than the layering method. Ceramic press-on sintered metal was suggested for fabrication restoration.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}