Improvement of Dentin Growth Parameters (Beta-catenin, bFGF, CD105, and BMP4) with Propolis as Adjuvant in Dental Caries Treatment.

Q1 Dentistry

European Journal of Dentistry Pub Date : 2024-12-10 DOI:10.1055/s-0044-1791939

Retno Pudji Rahayu, Nirawati Pribadi, Ira Widjiastuti, Nur Ariska Nugrahani

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引用次数: 0

Abstract

Objective: The purpose of the study was to evaluate the efficacy of calcium hydroxide (Ca(OH)₂) and propolis in pulp capping for dental caries treatment, focusing on dentin growth parameters. The study also aims to determine the role of propolis as a natural adjuvant therapy in enhancing reparative dentin development while emphasizing the importance of proper technique and material preparation with markers for the expression of beta-catenin, bFGF, CD105, and BMP4.

Materials and methods: The left bottom molar teeth from 28 Wistar rats were divided into four groups. The first group, the control group, was given only aqua dest, and the second group received drilling treatment and additional therapies with Ca(OH)₂ (Ca(OH)₂) 0.625 μg. The third group was given drilling treatment and additional therapies with a combination of propolis with Ca(OH)₂ 0.781 μg until day 7. Finally, the fourth group received a combination of propolis with Ca(OH)₂ 0.781 μg until day 14. This research analyzed the expression of essential basic fibroblast growth factor (bFGF), CD105, beta-catenin, and bone morphogenetic protein 4 (BMP4).

Results: This research reports that the average expression of BMP4 and bFGF showed a significant result in treatment with additional therapies with propolis and Ca(OH)₂. The experiment indicates that propolis and Ca(OH)₂ could induce reparative dentine on days 7 and 14.

Conclusion: Propolis as an adjuvant shows better reparative dental formation with improvement in the expression of bFGF and BMP4 in 14 days of therapy.

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来源期刊

European Journal of Dentistry Dentistry-Dentistry (all)

CiteScore

5.10

自引率

0.00%

发文量

161

期刊介绍： The European Journal of Dentistry is the official journal of the Dental Investigations Society, based in Turkey. It is a double-blinded peer-reviewed, Open Access, multi-disciplinary international journal addressing various aspects of dentistry. The journal''s board consists of eminent investigators in dentistry from across the globe and presents an ideal international composition. The journal encourages its authors to submit original investigations, reviews, and reports addressing various divisions of dentistry including oral pathology, prosthodontics, endodontics, orthodontics etc. It is available both online and in print.