European Journal of Dentistry最新文献

{"title":"Effect of Surface Cleaning and Heat Treatment on Shear Bond Strength of Cement-Contaminated Zirconia.","authors":"Laksika Suwannachot, Niyom Thamrongananskul, Suparaksa Yamockul, Atikom Surintanasarn","doi":"10.1055/s-0045-1811225","DOIUrl":"https://doi.org/10.1055/s-0045-1811225","url":null,"abstract":"<p><p>This study aimed to evaluate the shear bond strength (SBS) of zirconia to dual-cured resin cement following various cleaning protocols and surface treatments after cement contamination.Seventy-seven zirconia specimens (5 × 5 × 2.5 mm³) were fabricated, polished, and randomly divided into seven groups (<i>n</i> = 11). Ten specimens per group were tested for SBS, and one was reserved for scanning electron microscopy. Group C- was cemented without surface treatment, while group C+ received air abrasion prior to cementation. Groups F - , F + , FT + , S - , and S+ were initially air-abraded and then contaminated with resin cement. F-series groups were cleaned using a furnace, and S-series with a piezoelectric scaler. Among these, F + , FT + , and S+ received additional air abrasion prior to re-cementation, whereas F- and S- did not. Groups F+ and S+ were re-cemented immediately, whereas FT+ was re-cemented 7 days after surface re-treatment. All specimens were artificially aged before SBS testing.One-way ANOVA followed by Tukey's HSD post-hoc test was used for statistical analysis (α = 0.05).Statistically significant differences in SBS were found among the groups (<i>p</i> < 0.05). Group F+ demonstrated the highest bond strength (6.60 ± 1.10 MPa), followed by groups C+ (6.59 ± 0.94 MPa) and S+ (5.42 ± 0.87 MPa), with no significant differences among these three. The lowest SBS was observed in group C- (2.66 ± 0.51 MPa). Intermediate values were recorded in groups F- (4.17 ± 0.95 MPa), FT+ (4.41 ± 0.95 MPa), and S- (4.60 ± 1.17 MPa), which did not differ significantly from each other.Cleaning cement-contaminated zirconia using a furnace or piezoelectric scaler, followed by air abrasion and immediate re-cementation, significantly improves SBS to levels comparable with clean, air-abraded zirconia. Air abrasion enhances bonding efficacy, while delayed re-cementation may diminish bond strength even after surface re-treatment.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Antifungal Efficacy of Natural Gum Acacia and Aloe Vera against Candida albicans on Conventional and Digital Denture Base Materials: An In Vitro Study.","authors":"Mai Salah El-Din, Hend Zeitoun, Mostafa I Fayad, Muhammad Sohail Zafar, Redhwan Saleh Al-Gabri, Ahmed Yaseen Alqutaibi, Rania Moussa","doi":"10.1055/s-0045-1810440","DOIUrl":"https://doi.org/10.1055/s-0045-1810440","url":null,"abstract":"<p><p>This study evaluated the efficacy of Acacia Arabica and aloe vera solutions versus commercial effervescent tablets on <i>Candida</i> viability and adhesion to various denture bases with different materials and manufacturing techniques.A total of 96 square-shaped denture base specimens (24 per group) were fabricated from heat-cured polymethyl methacrylate (PMMA), thermoformed polyamide (FlexiUltra), milled computer-aided design and computer-aided manufacturing (CAD/CAM; Avadent), and 3D-printed (FormLabs) resins. Specimens were allocated into a control group (distilled water) and three experimental groups (<i>n</i> = 6 per group) based on the immersion solutions: Gum acacia (GA), aloe vera, and alkaline peroxide denture cleansers. One specimen from each material subgroup was prepared for qualitative assessment. All specimens were incubated with <i>Candida albicans</i> for 48 hours and immersed in the designated disinfectant solution for 8 hours. Anti-<i>C. albicans</i> biofilm activity was assessed quantitatively using an MTT assay and qualitatively using a confocal laser scanning microscope (CLSM).One-way analysis of variance (ANOVA) was employed for mean comparison, and data were considered significant at <i>p</i> < 0.05.The reduction in mean <i>Candida</i> viability was greatest in the alkaline peroxide tablets across all denture base materials, followed by GA and aloe vera (<i>p</i> < 0.001). GA demonstrated a statistically significant reduction in <i>Candida</i> levels in the thermoplastic polyamide (<i>p</i> < 0.001). The mean viability of <i>Candida</i> in both alkaline peroxide tablets and GA was statistically similar in digital denture bases (<i>p</i> > 0.05).The antifungal efficacy of alkaline peroxide denture cleansers was determined to be the highest. The cost-effective GA may serve as a viable denture disinfectant, particularly for thermoformed polyamide denture bases.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Salivary and Serum BAFF and TWEAK Levels in Patients with Thalassemia Major and Gingival Inflammation: An Observational Case-Control Study.","authors":"Rua'a Riyadh, Maha Sh Mahmood","doi":"10.1055/s-0045-1810423","DOIUrl":"10.1055/s-0045-1810423","url":null,"abstract":"<p><p>Limited research has been conducted to evaluate the relationship between periodontal parameters, systemic biomarkers, and thalassemia major (TM) concerning gingival inflammation. This study aims to assess the potential association of B cell activating factor (BAFF) and tumor necrosis factor weak inducer of apoptosis (TWEAK) with periodontal parameters in patients diagnosed with TM and gingivitis, compared with their healthy counterparts.The current study involved 101 participants aged 18 to 35 years; each subject completed a preliminary assessment to ascertain their eligibility for recruitment. Periodontal parameters were recorded, including the following indices: plaque index, bleeding on probing, and the Oral Hygiene Simplified Index (OHS-I-calculus index). The concentrations of BAFF and TWEAK in saliva and serum were evaluated using enzyme-linked immunosorbent assay.The Mann-Whitney and the Kruskal-Wallis tests were employed for comparisons, with the Dunn-Bonferroni <i>post hoc</i> method applied for pairwise multiple comparisons when applicable. Intraclass correlation coefficient and kappa tests were used to test the reliability of the examiner calibration. Spearman rank correlation was used to assess the relationship between the biomarkers under study and clinical periodontal data. Additionally, multiple linear regression analysis was utilized to investigate the association of biomarkers, TM, and gingivitis while controlling for potential confounding effect of age. <i>p</i>-Values below 0.05 were set to be statistically significant.Both biomarkers were detected in all subjects, with a significant difference in their levels between the groups. Additionally, significant correlations were found between the levels of TWEAK and BAFF and periodontal indices (<i>p</i> < 0.001). Multiple linear regressions demonstrated a significant association between the elevated levels of salivary and serum BAFF and TWEAK with TM and gingival health status (<i>p</i> < 0.05), as for age was not statistically significant.The findings demonstrate a possible correlation between elevated salivary and serum levels of BAFF and TWEAK and the presence of TM and gingival inflammation, suggesting that these biomarkers may reflect systemic immune alterations in TM in the presence of gingival inflammation.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RANKL Gene Polymorphism rs9594738 in Cases of Malocclusion Due to Persistence of Primary Teeth in Minangkabau Children.","authors":"Fuccy Utamy Syafitri, Amin Akbar, Nila Kasuma, Reno Wiska Wulandari, Dwinda Rahmadhani","doi":"10.1055/s-0045-1810422","DOIUrl":"10.1055/s-0045-1810422","url":null,"abstract":"<p><p>Malocclusion is an important dental health problem, especially in children. One factor causing malocclusion is the persistence of primary teeth, which genetic factors can influence. This study provides a new understanding of the role of genetics in causing malocclusion and its impact on preventive planning and orthodontic treatment.This was an observational analytic study with a cross-sectional research design. The research subjects were children of SD Pembangunan UNP Padang, Minangkabau tribe, aged 6 to 13 years, a total of 30 people, consisting of a case group and a control group. Saliva was collected using a nonstimulated method (passive salivation). The polymorphism of the RANKL rs9594738 gene was analyzed using the polymerase chain reaction-restriction fragment length polymorphism method. Amplification results were analyzed via agarose gel electrophoresis to determine genotype. Data analysis was performed using the chi-square test.RANKL rs9594738 gene polymorphism in the case group was higher than in the control group. The chi-square test shows an association between RANKL rs9594738 gene polymorphism and dental malocclusion due to the persistence of primary teeth.The data shows that the RANKL rs9594738 gene polymorphism is associated with dental malocclusion due to the persistence of primary teeth. The occurrence of malocclusion due to the persistence of primary teeth is a multigenetic phenomenon. In addition to the RANKL gene, osteoprotegerin, and matrix metalloproteinases, other genes that affect the replacement of primary teeth to permanent teeth are colony-stimulating factor 1, tumor necrosis factor ligand superfamily member 11, runt-related transcription factor 2, interleukin-1β, cathepsin K, sclerostin, and parathyroid hormone.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shaping the Future of Dentistry: How Digital VR-Haptic Thinkers Are Revolutionizing Education by Thinking Big for Better Future in Oral Care.","authors":"Reinhard Chun Wang Chau, Manchorova Neshka, Mihaela Pantea, Sarah Rampf, Mikko Liukkonen, David R Rice, David Morton, Octave Nadile Bandiaky, Masako Nagasawa, Kinga Bágyi, Barry F Quinn, Esther Carramolino-Cuéllar, Sónnica Galán-Gil, Nicla Flacco, Damiano Pasqualini, Muhammad A Shazib, Simona-Georgiana Schick, Bekhzod Yarmukhamedov, Kristin Ackerman, Santiago Arias-Herrera, Ulla-E Palotie, Ahmed Adam Kada, Nawal Bouyahyaoui, Edgar Quenta-Silva, Gitana Rederiene, Nisrine El Arrouf, María P Rodríguez-Hopp, Anna L Suominen, Hannelie Edgar, Nicola Shanks, Amanda Jackson, Brid Hendron, Sila Nur Usta, Peter Lingström, Ulf Örtengren, Margrit Maggio, Niku Sondagar, Maxstein M Abuzaid, Małgorzata Ponto-Wolska, Walter Yu Hang Lam, Piotr A Regulski, Outi Huhtela, Łukasz Zadrożny, Mengwei Pang, Suzie Bergman, Szabolcs Felszeghy, Sompop Bencharit, Maria F Sittoni-Pino","doi":"10.1055/s-0045-1810611","DOIUrl":"10.1055/s-0045-1810611","url":null,"abstract":"<p><p>Integrating digital, virtual reality (VR), and haptic technologies into dental education transforms training by fostering immersive, student-centered environments. These tools bridge theoretical knowledge and clinical practice, enhancing psychomotor skills, reducing anxiety, and enabling standardized assessments in risk-free settings. The Digital, VR, and Haptic Thinkers Network drives global collaboration and innovation. Drawing on insights from a 2025 conference at Queen Mary University of London, this commentary explores advancements, challenges, and future directions for VR-haptic integration in dental curricula. Results from global implementations, including improved manual dexterity and procedural precision, as well as enhanced pulpotomy performance, demonstrate a significant educational benefit. In clinical dentistry, VR-haptic simulators enhance patient outcomes by facilitating precise skill development for procedures in restorative dentistry and endodontics, thereby reducing errors in real-world practice. Combining these technologies with traditional methods is proposed to prepare competent, confident dental professionals while addressing educational disparities. Rigorous validation, strategic curriculum integration, and interdisciplinary collaboration are recommended to maximize impact.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of rhBMP-2-Loaded Collagen Sponge for Alveolar Ridge Preservation: A Pilot Study.","authors":"Peungchaleoy Thammanichanon, Warisara Ouyyamwongs, Katanchalee Mai-Ngam, Pawornwan Rittipakorn","doi":"10.1055/s-0045-1810610","DOIUrl":"https://doi.org/10.1055/s-0045-1810610","url":null,"abstract":"<p><p>Alveolar bone resorption following tooth extraction poses a significant clinical challenge. While various ridge preservation techniques exist, limitations remain. Recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered via an absorbable collagen sponge (ACS) has shown promise in bone augmentation. This pilot randomized controlled trial aimed to evaluate the efficacy of ACS combined with rhBMP-2 for alveolar ridge preservation in maintaining ridge dimensions after tooth extraction.This pilot randomized controlled trial enrolled 11 participants with 16 extraction sites, randomized to either the intervention (ACS/rhBMP-2) or the control (empty socket) group. The <i>in vitro</i> release kinetics of rhBMP-2 from the ACS carrier were measured over 13 days using ELISA (enzyme-linked immunosorbent assay). Clinical procedures involved atraumatic extraction, followed by the placement of ACS/rhBMP-2 in the intervention group. Alveolar ridge dimensions were assessed using cone-beam computed tomography at baseline (T0), and at 4 (T4), 8 (T8), and 12 weeks (T12) post-extraction.Data were presented as mean ± standard deviation. A linear mixed model was used to compare dimensional changes over time between the two groups. A <i>p-</i>value of <0.05 was considered statistically significant.The <i>in vitro</i> assay showed a gradual, sustained release of rhBMP-2 from the ACS, with a cumulative release of 7.28% (117 ± 5.18 µg) over 13 days. No postoperative complications were observed in any participant. At 12 weeks, the ACS/rhBMP-2 group demonstrated a statistically significant preservation of buccal bone height, with 1.80 mm less vertical reduction compared to the control group. No significant differences were found between groups for palatal/lingual bone reduction or for changes in the overall bucco-lingual ridge width.The application of ACS combined with rhBMP-2 is an effective approach for mitigating buccal bone resorption after tooth extraction. This intervention is clinically significant as it preserves critical buccal plate height, potentially reducing the need for further augmentation prior to implant placement, even though it does not prevent overall ridge width collapse.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Patient Satisfaction and Oral Health-Related Quality of Life Following Anterior Maxillary Implant Placement: A Five-Year Follow-Up Study.","authors":"Hanen Boukhris, Hajer Zidani, Ghada Bouslama, Kawther Bel Haj Salah, Souha BenYoussef","doi":"10.1055/s-0045-1811195","DOIUrl":"https://doi.org/10.1055/s-0045-1811195","url":null,"abstract":"<p><p>Long-term data evaluating both patient satisfaction and oral health-related quality of life (OHRQoL) in anterior maxillary implant rehabilitation are still limited, making this investigation highly relevant. This study aimed to evaluate patient satisfaction and OHRQoL 5 years after anterior maxillary implant placement. It specifically assessed long-term satisfaction with implant-supported restorations in the aesthetic zone, the impact on OHRQoL, and key clinical and prosthetic factors influencing perceived treatment success.A prospective study was conducted at the University Hospital of Farhat Hached, Sousse, Tunisia, from March to June 2024. Eligible patients who underwent anterior maxillary implant placement between 2018 and 2019 were included. Patients with fixed implant-supported restorations and good systemic health were eligible, while those with parafunctional habits or incomplete follow-up data were excluded. Satisfaction was assessed using a Visual Analog Scale (VAS), and OHRQoL was measured using the Oral Health Impact Profile (OHIP)-14 and Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) questionnaires. A total of 50 patients participated. The sample size was determined based on an expected satisfaction rate of 80%, with a 95% confidence interval and a 10% margin of error, resulting in a required minimum of 47 participants.Data analysis was performed using SPSS version 20. Descriptive statistics summarized demographics, satisfaction scores, and OHRQoL outcomes. Inferential analyses included paired <i>t</i>-tests and Wilcoxon signed-rank tests to compare baseline and 5-year follow-up data. Spearman's correlation was used to examine relationships between implant-related factors and satisfaction or OHRQoL scores, while multivariate regression identified predictors of long-term satisfaction. A <i>p</i>-value of < 0.05 was considered statistically significant.Fifty patients (mean age: 36.5 ± 5.3 years) participated, with a 98.04% implant survival rate. At 5 years, 86.2% reported high satisfaction, with a mean VAS score of 92.8%. Phonetic outcomes received a 100% satisfaction rate, while chewing comfort and stability were also highly rated (94.0 and 93.7%, respectively). Esthetic satisfaction was reported by 85.0% of patients, and 67.5% had no difficulty maintaining hygiene. The OHIP-14 median score of 9.0 indicated minimal OHRQoL impairment. PIDAQ results showed that while most patients were satisfied with esthetics, some experienced psychosocial impacts.Five years after anterior maxillary implant placement, patients reported high satisfaction, especially regarding phonetics, chewing comfort, and esthetics. The minimal OHRQoL impact and low PIDAQ scores highlight the positive psychosocial effects of implant restorations. These results suggest that long-term evaluation of functional and psychological outcomes should be integrated into clinical decision-making and future prospective studies.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Acacia arabica Addition on Optical, Mechanical, and Fungicidal Properties of Polymethyl Methacrylate Denture Base Material.","authors":"Rania Moussa, Ahmed Yaseen Alqutaibi, Muhammad Sohail Zafar, Mai Salah El-Din","doi":"10.1055/s-0045-1810070","DOIUrl":"https://doi.org/10.1055/s-0045-1810070","url":null,"abstract":"<p><p>The aim of the study was to evaluate the optical, mechanical, and microbiological performance of heat-cured polymethyl methacrylate (PMMA) modified by adding various gum <i>Acacia arabica</i> (GA) concentrations.Specimens containing 1, 2.5, 5, 7.5, and 10% GA by weight were prepared, with control specimens containing no GA. Thirty-six rectangular samplings were assessed for color changes, flexural strength, and elastic modulus. Color measurement was conducted using a spectrophotometer. A universal testing machine measured flexural strength through a three-point bending test, and the elastic modulus was calculated. A profilometer and Vickers hardness tester evaluated the surface roughness and hardness. Antifungal activity was assessed by incubating specimens with <i>Candida albicans</i> and counting colony-forming units (CFU/mL).Data were analyzed using the Kruskal-Wallis test for antifungal activity and optical properties and One-way ANOVA for mechanical properties at a significance level of <i>p</i> < 0.05.Groups with higher GA concentrations exhibited significant color changes (<i>p</i> < 0.001). Nonsignificant changes were reported in flexural strength, elastic modulus, or surface hardness (<i>p</i> >0.05), although lower concentrations of GA (1 and 2.5% wt) improved surface hardness. Both 7.5% and 10% wt GA significantly increased surface roughness (<i>p</i> < 0.001). Antifungal activity increased with GA concentration declining from 12 × 10⁸ CFU/mL in the control to no detectable fungal growth in the 10% wt.Low GA concentrations (1 and 2.5%) improved hardness with minimal surface changes, while higher levels (7.5 and 10%) significantly enhanced antifungal efficacy but compromised roughness and aesthetics. A 5% GA concentration offered a balanced compromise, necessitating further investigation.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Saussurea costus Nanoparticles in the Treatment of Periodontitis: Impact on NF-κB and TNF-α Expression.","authors":"Azzahra Salsabila Adira Moelyanto, Ira Arundina, Theresia Indah Budhy, Meircurius Dwi Condro Surboyo, Aqsa Sjuhada Oki, Cheng Hwee Ming","doi":"10.1055/s-0045-1810069","DOIUrl":"https://doi.org/10.1055/s-0045-1810069","url":null,"abstract":"<p><p><i>Porphyromonas gingivalis</i> is a major contributing pathogen in periodontitis and triggers an inflammatory response that leads to tissue damage, primarily through the activation of proinflammatory cytokines such as nuclear factor kappa B (NF-κB) and tumor necrosis factor-α (TNF-α). <i>Saussurea costus</i>, a medicinal plant known for its anti-inflammatory properties, offers a potential alternative to prevent inflammation. This study explores the effects of <i>S. costus</i> nanoparticles on inflammation in periodontitis, specifically examining their ability to reduce the expression of NF-κB and TNF-α.Twenty male Wistar rats were injected <i>with P. gingivalis</i> into the central incisor region of the mandible to induce periodontitis. The rats were then treated with <i>S. costus</i> nanoparticles, alongside a control group. Immunohistochemical staining was performed to assess the expression of NF-κB and TNF-α at two time points: 2 and 5 days posttreatment. Bone and lower anterior gingival sulcus tissues were analyzed for immunohistochemical expression of these markers.Statistical analysis was performed using the Kruskal-Wallis and Mann-Whitney U tests.Treatment with <i>S. costus</i> nanoparticles resulted in significantly lower expressions of NF-κB and TNF-α compared with the control group at both 2 and 5 days posttreatment (<i>p</i> < 0.05).The <i>S. costus</i> nanoparticles effectively reduced NF-κB and TNF-α expression in periodontitis, with a more pronounced effect observed on day 5 compared with day 2, suggesting its potential as a therapeutic agent in managing periodontal inflammation.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accumulated Hard-tissue Debris Removal Using Different Ultrasonic Power Settings: A Micro-CT Study.","authors":"Flávia de Moura Pereira, Kusai Baroudi, Tarun Walia, Vivek Padmanabhan, Emmanuel Joao Nogueira Leal da Silva, Carolina de Oliveira Lima, Rafael Pino Vitti, Rayana Duarte Khoury, Flávia Goulart da Rosa Cardoso","doi":"10.1055/s-0045-1810441","DOIUrl":"https://doi.org/10.1055/s-0045-1810441","url":null,"abstract":"<p><p>To evaluate the effectiveness of the Irrisonic Power ultrasonic tip activated at different power settings (10 and 30%) on the removal of accumulated hard-tissue debris (AHTD) from mandibular premolars using micro-computed tomography (micro-CT) analysis.A total of 20 extracted mandibular premolars were pair-matched based on root canal morphology using micro-CT imaging. All specimens were prepared with Reciproc R25 and randomly assigned to two experimental groups (<i>n</i>  =  10) according to the power setting used during final irrigation: Irrisonic Power 10% or Irrisonic Power 30%. Supplementary irrigation was performed with sodium hypochlorite and EDTA. AHTD was quantified pre- and post-irrigation using standardized micro-CT analysis and ImageJ software.Data were statistically analyzed using the Mann-Whitney test (<i>α </i> =  0.05).Both protocols significantly reduced AHTD after supplementary irrigation. The Irrisonic Power 30% group exhibited lower residual debris (0.16  ±   0.13%) than the Irrisonic Power 10% group (0.90  ±   1.16%), with a statistically significant difference (<i>p</i> <  0.05).Supplementary irrigation with the Irrisonic ultrasonic tip at 30% power was more effective in removing AHTD than the 10% power setting.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144798538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}