European Journal of Dentistry最新文献

{"title":"YAP Expression is Related to the Aggressive Behavior of Odontogenic Cysts.","authors":"Jutamas Uttagomol, Adjabhak Wongviriya, Ariya Chantaramanee, Thanit Prasitsak","doi":"10.1055/s-0044-1801275","DOIUrl":"https://doi.org/10.1055/s-0044-1801275","url":null,"abstract":"<p><strong>Objective: </strong> Yes-associated protein (YAP) and Ki-67 are known to be involved in cell proliferation. While their overexpression is associated with aggressive behaviors in oral squamous cell carcinoma (OSCC), their roles in odontogenic cysts have not been thoroughly investigated. Therefore, this study aimed to evaluate the immunohistochemical expression of YAP and Ki-67 in odontogenic cysts.</p><p><strong>Material and methods: </strong> Tissue samples included 12 radicular cysts, 10 dentigerous cysts, 9 odontogenic keratocysts, and 9 normal oral mucosa specimens. Immunohistochemical analysis was conducted both manually and using ImageJ software for comparison.</p><p><strong>Statistical analysis: </strong> The Kruskal-Wallis, followed by the Mann-Whitney <i>U</i>-test was used to assess the differences in the YAP and Ki-67 immunoexpression levels among various group lesions. The correlation between those two proteins in individual groups was tested by Spearman correlation. A <i>p</i>-value of less than 0.05 was considered statistically significant. SPSS software version 25.0 was used.</p><p><strong>Results: </strong> There was a strong nuclear staining of YAP in basal and superficial cells and an intense cytoplasmic YAP positivity in odontogenic keratocysts, whereas a weaker YAP staining in both the nucleus and cytoplasm throughout the epithelial thickness was observed in dentigerous cyst, radicular cyst, and normal oral mucosa, respectively. YAP expression differed significantly in all odontogenic cysts compared with normal oral mucosa (<i>p</i> < 0.05). Ki-67 expression was notably higher in odontogenic keratocysts relative to other cysts and normal oral mucosa. Although no statistically significant correlation was found between YAP and Ki-67 across the groups, both proteins displayed similar positive trends in odontogenic keratocysts.</p><p><strong>Conclusion: </strong> These findings suggest that YAP activation may be related to the proliferative behavior of odontogenic cysts, especially in more aggressive lesions, but less likely to influence the inflammatory cysts. This insight could improve understanding of their pathogenesis and pave the way for new diagnostic and therapeutic approaches.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review and Meta-Analysis of the Prevalence of Dental Caries in the Permanent Teeth of Arab Children.","authors":"Huda Abutayyem, Mohammad Khursheed Alam, Maher Al Shayeb, Raghad Hashim","doi":"10.1055/s-0044-1795117","DOIUrl":"10.1055/s-0044-1795117","url":null,"abstract":"<p><p>Despite the global prevalence of dental caries, there is a paucity of comprehensive data on the extent of this issue among children in the Arab region. This systematic review and meta-analysis aimed to evaluate the prevalence of dental caries and the associated Decayed, Missing, and Filled Teeth (DMFT) indices in permanent teeth among children from 4 to under 18 years of age in the Arab region. A comprehensive review of various studies was conducted. Studies were searched across eight different electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. The random effects (RE) model was used for analysis, allowing variation in effect sizes across studies.The RE model suggested a high caries prevalence rate of 72.62% (with a 95% confidence interval of 65.3%-78.89%), suggesting a large burden of dental caries in this population pertaining to permanent teeth. The <i>I</i> ² score was 99.0%, showing high heterogeneity among the investigations. The mean DMFT score was found to be 1.675 (with a 95% confidence interval of 0.5519-2.7980), indicating of substantial dental health concerns. Surprisingly, the <i>I</i> ² value for DMFT scores was 0.0%, demonstrating no detected heterogeneity among the trials. The study highlights a high prevalence of dental caries and significant DMFT scores among children in the Arab region, signaling an urgent public health concern. The lack of heterogeneity in DMFT scores across studies, despite high caries prevalence, suggests potential limitations in the DMFT indices' ability to capture the full severity of dental caries. Further research is needed to refine these tools and fully understand the burden of dental caries in this population.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"275-285"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Mechanical and Elemental Properties of Bioceramic-Coated Orthodontic Brackets and Enamel Surface.","authors":"Abdul Samad Khan, Ahlam AlAbdali, Nadia Irshad, Othoob AlMusayyab, Norah AlQahtani, Asma Tufail Shah, Sultan Akhtar, Yassine Slimani","doi":"10.1055/s-0044-1789003","DOIUrl":"10.1055/s-0044-1789003","url":null,"abstract":"<p><strong>Objective: </strong> The aim is to coat orthodontic brackets with two different bioactive materials and to compare the mechanical and morphological properties of coated brackets and tooth surfaces.</p><p><strong>Materials and methods: </strong> A total of 120 stainless steel brackets were divided equally into three groups, that is, the uncoated brackets and nanohydroxyapatite (nHA)-coated, and nanobioactive glass (nBG)-coated brackets using a spin coater machine. The brackets were bonded on the enamel surface and underwent remineralization/demineralization cycles for days 1, 7, 14, and 30. At each time interval, the bond strength of the brackets was assessed using mechanical loading. An optical and scanning electron microscope (SEM) were used for surface evaluation, and the adhesive remanent index (ARI) values were obtained and quantified.</p><p><strong>Statistical analysis: </strong> One-way analysis of variance using Tukey's test was used to compare the differences among the groups.</p><p><strong>Results: </strong> A uniform distribution of nanoparticles occurred on the surfaces of brackets. The shear bond strength (SBS) showed no significant differences in any tested groups on days 1, 7, and 14. However, control and nBG showed a significant difference from nHA at day 30. On days 7, 14, and 30, the nHA group showed the highest SBS values among the groups. For ARI, most samples showed an adhesive nature of failure at the enamel-brackets interface. The images confirmed the presence of coated particles on brackets and remnants of adhesives after SBS.</p><p><strong>Conclusion: </strong> This study confirmed that the nHA- and nBG-coated brackets have a high potential for application in orthodontics regarding structural and mechanical properties.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"389-398"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utilization of Ultrashort Bicon Implants in Clinical Situations: A Retrospective Case Series.","authors":"Damian Dudek, Gregori M Kurtzman, Karpe Jacek, Arkadiusz Badziński, Edyta Reichman-Warmusz","doi":"10.1055/s-0044-1791786","DOIUrl":"10.1055/s-0044-1791786","url":null,"abstract":"<p><p>When vertical bone loss results in insufficient crestal height to place standard-length implants without the use of osseous grafting, this poses clinical issues to implant usage. Based on an analysis of the literature and clinical experience, it has been found that it is possible to optimally use the available bone volume of the maxillary and mandibular ridges for implant placement without extensive osseous grafting to increase vertical height. This case report will examine several uses of ultrashort implants utilizing the Bicon system in common clinical situations in the maxillary and mandibular arches without the need for osseous reconstruction to improve the available vertical height of the crest to permit implant placement.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"544-550"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Internal Accuracy of Ceramic Veneered Sintered Metal versus Cast Metal Restoration Upon Different Fabrication Processes.","authors":"Sanephume Sripairojn, Niwut Juntavee, Apa Juntavee","doi":"10.1055/s-0045-1807730","DOIUrl":"https://doi.org/10.1055/s-0045-1807730","url":null,"abstract":"<p><p>One critical factor that influences clinical outcomes of fixed dental restorations is the internal gaps between the restoration and the abutment tooth. However, investigating these gaps in the context of fabrication processes with new technologies is few. This study compared internal accuracy of sintered versus cast metal substructures upon different fabrication techniques, veneered with layering and press-on ceramic, during different construction stages, at different sites of restoration.A total of 96 metal substructures were fabricated with a standardized dimension from four techniques: cast metal with traditionally impressed tooth [CmTt], cast metal with digitally milled wax [CmDw], sintered metal with digitally impressed tooth [SmDt], and sintered metal with digitally impressed stone model [SmDm]. They were further subdivided into two subgroups according to the veneering ceramic used [layered (Pl) and press-on (Pp)]. Internal accuracy was evaluated at gingival, gingiva-axial, axial, axio-occlusal, and occlusal locations using silicone replica, after metal coping (As), degassing (De), opaque application (Op), contouring (Co), and glazing (Gl).Analysis of variance and Bonferroni tests were analyzed for significant differences of internal fit upon different factors (<i>α</i> = 0.05).Significantly different internal accuracy was found upon metal substructures fabrication technique, veneering methods, stages, and sites of restoration (<i>p</i> < 0.05). SmDt and SmDm revealed significantly better fit than CmTt and CmDw (<i>p</i> < 0.05). Pp generated significantly better fit than Pl (<i>p</i> < 0.05). Significantly increasing gaps were found upon stages (<i>p</i> < 0.05). Occlusal and axio-occlusal sites exhibited larger gaps than axial, gingivo-axial, and gingival sites (<i>p</i> < 0.05). However, all groups exhibited clinically acceptable internal accuracy.Increasing internal inaccuracies upon stages of fabrication were noticed, with highly observed at the occlusal and axio-occlusal sites. Sintered metal (SmDt, SmDw) provided better accuracy than cast metal (CmTt, CmDw) while press-on veneering generated better accuracy than the layering method. Ceramic press-on sintered metal was suggested for fabrication restoration.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Comparison of Guided Biofilm Therapy and Scaling and Root Planing in the Active Phase of Periodontitis Management.","authors":"Magda Mensi, Annamaria Sordillo, Silvia Marchetti, Stefano Calza, Eleonora Scotti","doi":"10.1055/s-0044-1791221","DOIUrl":"10.1055/s-0044-1791221","url":null,"abstract":"<p><strong>Objective: </strong> The aim of this randomized, controlled, split-mouth study was to compare full-mouth air polishing followed by ultrasonic debridement (known as Guided Biofilm Therapy [GBT]) versus traditional Scaling and Root Planing (SRP), in terms of pocket closure in patients with stages III and IV periodontitis.</p><p><strong>Materials and methods: </strong> The patients underwent periodontal therapy in two sessions. At the beginning of the first session, quadrants I and IV and II and III were randomly assigned to GBT or SRP treatment. Periodontal parameters were collected at baseline, 6 weeks (T1), and 3 months (T2) after therapy. The primary outcome was the number of experimental sites (pocket probing depth [PPD] >4 and <10 mm) becoming closed pockets (PPD ≤ 4 mm bleeding on probing [BOP] negative) at T1 and T2. Secondary outcomes were PPD, recession, clinical attachment level, BOP, and plaque index variations at the experimental sites and treatment time.</p><p><strong>Statistical analysis: </strong> A 10% difference in the primary outcome between the two protocols was set as the threshold to define inferiority/noninferiority of the test treatment. The primary outcome was modeled using a generalized estimating equation model to account for intrapatient measurement correlation. The estimates are reported as differences between groups' percentages (treatments or time points) and corresponding 95% confidence interval (95% CI). All analyses assumed a significance level of 5%.</p><p><strong>Results: </strong> A total of 32 patients were selected. Mean PPD (mm) reduced from 6.23 (6.06-6.40) to 3.33 (3.06-3.61) at T2 for GBT, and from 6.21 (6.04-6.38) to 3.32 (3.11-3.53) at T2 for SRP. Both treatments reached a comparable percentage of closed pockets at T1 (77.9% for GBT vs. 80.1% for SRP, <i>p</i> = 0.235) and T2 (84.1% for GBT vs. 84.4% for SRP, <i>p</i> = 0.878), with no statistically or clinically significant difference. GBT and traditional SRP with ultrasonic and hand instruments reach satisfactory clinical results in the active treatment of patients with stages III and IV periodontitis, with comparable rates of closed pockets and treatment time.</p><p><strong>Conclusion: </strong> GBT is a suitable option in the active phase of periodontitis management in patients with stages III and IV periodontitis.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"482-492"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Glutaraldehyde-Based Desensitizer on Control of Tooth Sensitivity and Tooth Color Post-bleaching: A Randomized Clinical Trial.","authors":"Raíssa Araújo de Mesquita, Elma Vieira Takeuchi, Maria Eduarda Cardoso de Oliveira Pereira, Jesuina Lamartine Nogueira Araújo, Eliane Bermeguy Alves, Cecy Martins Silva","doi":"10.1055/s-0044-1789603","DOIUrl":"10.1055/s-0044-1789603","url":null,"abstract":"<p><strong>Objectives: </strong> This randomized, controlled, single-blind, split-mouth clinical study evaluated the effect of the application of a glutaraldehyde-based desensitizer on the prevention of tooth sensitivity (TS) and the changes in the color of the teeth after bleaching.</p><p><strong>Materials and methods: </strong> Twenty-five patients were selected for participation in the study according to the inclusion and exclusion criteria. The patients' right and left hemiarches were randomized into two groups: the placebo group, which received distilled water application and whitening treatment, and the Gluma group, which received Gluma application, followed by whitening treatment. The patients were examined after three bleaching sessions with 35% hydrogen peroxide. TS was measured using a numerical rating scale for 21 days from the beginning of bleaching. The tooth color was monitored using a spectrophotometer at times T0 (baseline) and T1 (after 21 days). The color analysis results were recorded using the CieLab system; the CIEDE2000 formula was applied to obtain the ΔE⁰⁰ and ΔL values.</p><p><strong>Statistical analysis: </strong> For statistical analysis, the Friedman analysis of variance test was used for intragroup evaluation, and the Wilcoxon test was used for a between-group comparison of the TS results. Student's <i>t</i>-test paired the ΔE⁰⁰ and ΔL values of the groups. A 5% significance level was adopted.</p><p><strong>Results: </strong> Intragroup analysis of the sensitivity results showed a statistically significant difference between the pain levels evaluated through days 1 to 21 (<i>p</i> < 0.001), and the highest median values were observed on the days when the whitening sessions were performed (days 1, 8, and 15) and right after the sessions (days 2, 9, and 16). However, in the intergroup analysis, no statistical difference in sensitivity was found between the placebo and Gluma. No statistical difference was found between the influences of the placebo and Gluma treatments on the color obtained after tooth whitening using parameters ᐃE⁰⁰ and ᐃL (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong> The use of Gluma prior to bleaching does not prevent TS and does not interfere with the color results obtained by tooth bleaching.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"323-329"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship of HbA1c Serum Levels with the Severity of Periodontal Disease in Patients with Type 1 Diabetes Mellitus: A Cross-Sectional Study.","authors":"Rosana Costa, Marco Infante da Câmara, Fernando Figueira, José Júlio Pacheco, Catarina Pereira, Maria Gonçalves, Marta Relvas","doi":"10.1055/s-0044-1795123","DOIUrl":"10.1055/s-0044-1795123","url":null,"abstract":"<p><strong>Objective: </strong> According to the evidence, the level of glycemic control is of key importance in determining the increased risk of periodontal disease (PD). The aim of the study was to evaluate the role of metabolic control as a key factor leading to the development and severity of periodontitis and compare the periodontal and oral hygiene status with the glycated hemoglobin levels.</p><p><strong>Materials and methods: </strong> The evaluation was undertaken with diabetic patients (59 uncontrolled diabetics and 36 controlled diabetics) from a patient cohort of the Hospitalar Center of Tâmega e Sousa and subjects without diabetes (<i>n</i> = 95).</p><p><strong>Statistical analysis: </strong> The data were analyzed using IBM SPSS Statistics software (Statistical Program for Social Sciences), version 29.0 for Windows. In the logistic regression analysis, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The significance level was set at 0.05.</p><p><strong>Results: </strong> Periodontal parameters were increased in systemically compromised individuals especially those who were poorly controlled as compared with their healthy counterparts, which are important indicators of PD progression. Furthermore, uncontrolled type 1 diabetic mellitus (T1DM) patients showed increased plaque index (PI), which predisposes these individuals to a greater degree of periodontal destruction and tooth loss. Using a binary logistic regression, we observe a significant relation of the risk of severe periodontitis in T1DM subjects with family history of T1DM (<i>p</i> = 0.019; OR: 3.36; 95% CI: 1.22-9.21), alcohol consumption (<i>p</i> = 0.02; OR: 3.78; 95% CI: 1.23-11.63), periodontal probing depth (PPD) (<i>p</i> < 0.001; OR: 3.64; 95% CI: 14.74-90.34), and clinical attachment loss (<i>p</i> = 0.033; OR: 4.71; 95% CI: 1.13-19.59).</p><p><strong>Conclusion: </strong> Increased glycated hemoglobin levels were positively related with periodontal status. Uncontrolled systemically compromised individuals showed an increased Plaque index (PI), which predisposes to greater periodontal inflammation and tooth loss. Increased clinical attachment level, Periodontal probing depth (PPD) and family history of T1DM, and alcohol consumption were identified as potential risk factors for severe periodontitis in subjects with T1DM.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"438-448"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moringa oleifera L. Nanosuspension Extract Administration Affects Heat Shock Protein-10 and -70 under Orthodontics Mechanical Force In Vivo.","authors":"Ari Triwardhani, Alida Alida, Ervina Restiwulan Winoto, Adya Pramusita, Nurul Aisyah Rizki Putranti, Kristian Satrio Ariadi, Okso Brillian Pribadi, Amelia Aisyiah Anwar, Alqomariyah Eka Purnamasari, Rifqah Ananda Mappananrang, Putri Cahaya Situmorang, Wibi Riawan, Tengku Natasha Eleena Binti Tengku Ahmad Noor, Albertus Putera Nugraha, Alexander Patera Nugraha","doi":"10.1055/s-0044-1791937","DOIUrl":"10.1055/s-0044-1791937","url":null,"abstract":"<p><strong>Objective: </strong> The mechanical stimulation known as orthodontic mechanical force (OMF) causes biological reactions in orthodontic tooth movement (OTM). Heat shock protein-70 (HSP-70) needs pro-inflammatory cytokines to trigger bone resorption in OTM; nevertheless, heat shock protein-10 (HSP-10), a \"Alarmin\" cytokine, should control these pro-inflammatory cytokines to get the best alveolar bone remodeling (ABR). <i>Moringa oleifera</i> L. nanosuspension extract (MONE) has anti-inflammatory, antioxidant, and ABR-stimulating properties. The aim of the study was to examine <i>in vivo</i> HSP-10 and HSP-70 expressions under OMF following MONE application in Wistar rats (<i>Rattus norvegicus</i>).</p><p><strong>Material and methods: </strong> A total of 36 Wistar rats (<i>R. norvegicus</i>) were split up into eight groups: one for treatment (OMF + MONE) and one for control (OMF + MONE administration for days 1, 7, 14, and 21). By employing nickel-titanium coil springs and using 10 g of light force per millimeter to implant the orthodontic device, the OMF was completed. According to the day of observation, all of the samples were sacrificed. To perform an immunohistochemistry investigation, the premaxilla of the sample was isolated. Tukey's Honest Significant Different (HSD) test (<i>p</i> < 0.05) was performed after an Analysis of Variance (ANOVA) analysis of the data.</p><p><strong>Results: </strong> In both the OMF and MONE groups, HSP-70 peaked on day 14 and began to fall on day 21. HSP-10 peaked on day 21, but along with MONE, it also began to progressively decline on days 14 and 21, with significant differences (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong> According to immunohistochemistry evidence, postadministration of MONE markedly elevated HSP-10 but lowered HSP-70 expression in the alveolar bone of Wistar rats under OMF.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"523-530"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparison of Esthetic Preferences on Female Skeletal Class II Alterations among Laypeople of Different Facial Profiles.","authors":"Wiwan Tipyanggul, Chidsanu Changsiripun, Niramol Chamnannidiadha","doi":"10.1055/s-0044-1788654","DOIUrl":"10.1055/s-0044-1788654","url":null,"abstract":"<p><strong>Objectives: </strong> This study aimed to investigate the influences of assessors' different personal profiles on the esthetic perception of Class II facial profile corrections and the agreement between profile and silhouette images.</p><p><strong>Materials and methods: </strong> A profile photo of a female with skeletal Class II was digitally altered into three profile and three silhouette images (most pronounced Class II division 1 characteristic, more retruded upper lip position, and more protruded mandibular position). Ninety-six laypeople from three facial profile groups (straight, convex, and concave profiles) chose these images for facial attractiveness. Data were analyzed using an SPSS program. Cohen's kappa coefficient and intraclass correlation coefficients were applied to determine intraparticipant and intra-examiner reliabilities. Chi-square tests were used to test between-group preferences and the relationship of profile preference with other factors. Cohen's kappa coefficient was used to test the agreement in selecting profile and silhouette images (<i>p</i> = 0.05).</p><p><strong>Results: </strong> All groups favored profiles with a protruded mandibular position (11-degree facial contour angle [FCA] and 91-degree nasolabial angle [NLA]). Despite facial profile differences, preference remained consistent (<i>p</i> = 0.649). The convex group showed a stronger inclination toward an untreated-simulating profile (17-degree FCA and 91-degree NLA). Preferences were consistent regardless of sex (<i>p</i> = 0.198) and education (<i>p</i> = 0.105). The percentage of agreement between profile and silhouette images in the total sample was 67.71% (kappa = 0.386). All groups of participants chose the more retruded upper lip position (17-degree FCA and 107-degree NLA) profile in silhouette more than in photograph.</p><p><strong>Conclusion: </strong> All groups preferred a mandibular advancement-simulating profile. Using the photographs or silhouettes to assess the esthetic preference resulted in a similar trend. However, the flatter profile was more preferred in silhouette than in photograph.</p>","PeriodicalId":12028,"journal":{"name":"European Journal of Dentistry","volume":" ","pages":"366-373"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}