European journal of general medicine最新文献

{"title":"Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects","authors":"S. El-Kader, O. Al-Jiffri","doi":"10.29333/EJGM/81730","DOIUrl":"https://doi.org/10.29333/EJGM/81730","url":null,"abstract":"Introduction:Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation.\u0000Objective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients.Material and Methods:One hundred obese subjects of both genders (mean age 46.72± 3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m2. Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months.Results:Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-α), Interleukin – 6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA:Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05).Conclusions:weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91488571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Villoglandulary papillary adenocarcinoma co-existing with high-grade squamous intraepitelial lesion; arising from an endocervical polyp","authors":"S. Fındık, H. Görkemli","doi":"10.29333/EJGM/81745","DOIUrl":"https://doi.org/10.29333/EJGM/81745","url":null,"abstract":"Adenocarcinomas account for 10–20% of invasive cervical carcinomas. The villoglandular papillary adenocarcinoma has been recognized as a subtype of mucinous adenocarcinoma and identified as a distinctive histological entity from the usual invasive adenocarcinomas of the uterine cervix. We report a new case of villoglandulary papillary adenocarcinoma, which was peculiar because of its association with a co-existing high grade squamous intraepithelial lesion and arising from an endocervical polyp. Excellent prognosis of isolated villoglandulary papillary adenocarcinoma is important in terms of making differential diagnosis from other adenocarcinomas and eliminating unnecessary aggressive treatments. It is also important to keep in mind for pathologists since it allows them to examine endocervical polyps that we often encounter in daily life and shows that malignant tumoral lesions can develop from polyps.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86625306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Megalencephalic leukoencephalopathy: van der Knaap disease","authors":"Be Panil Kumar, Kishore K. Hegde, Amit Agrawal","doi":"10.29333/ejgm/81736","DOIUrl":"https://doi.org/10.29333/ejgm/81736","url":null,"abstract":"","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88718749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short course of high dose steroids used for non-pulmonary indication like anaphylaxis caused flare up of tuberculosis & presenting as acute pulmonary tuberculosis with pleural effusion: a case report","authors":"S. Patil, G. Gondhali","doi":"10.29333/ejgm/81734","DOIUrl":"https://doi.org/10.29333/ejgm/81734","url":null,"abstract":"Tuberculosis (TB) remains a major health problem in India, and accounts for nearly 20-30% of the global TB burden. Prevalence of tuberculosis infection in India is 40%, with pulmonary tuberculosis accounts for 80% cases, and in immune-competent individuals 5 to 10% chance of TB progressing from infection to disease during their lifetimes. Data is available for possible role of steroids used for pulmonary and non-pulmonary indications in increasing risk of new tuberculosis infection, reactivation of latent tuberculosis infection and relapse of treated disease. In this case report, 25 year male received high dose intravenous steroids for life threatening anaphylaxis because of bee sting bite only for four days caused reactivation of latent tuberculosis infection (LTBI). Clinical presentation is acute form of progressive pulmonary tuberculosis with pleural effusion which can be misdiagnosed as a community acquired pneumonia. High index of suspicion with adequate evaluation is must in all cases to have satisfactory treatment outcome.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80979835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritant phytocontact dermatitis caused by buttercup at various times: A series of three patients","authors":"A. Benli, M. Oruç, Selman Erturhan, D. Sunay","doi":"10.29333/EJGM/81735","DOIUrl":"https://doi.org/10.29333/EJGM/81735","url":null,"abstract":"Traditional herbal medicine is very common in the Anatolian regions and has been used for centuries. In this study, it was aimed to show the course of dermatitis in cases of phyto contact dermatitis caused by buttercups when the patients presented at different times after the application. 3 patients who lived in the same region presented at the family practice clinic because of lesions which emerged after the topical application of plants from the Ranunculaceae family for knee pain. The patients presented on the 1st, 4th and 15th day respectively after application and were all diagnosed with irritant phyto contact dermatitis. In Turkey, particularly amongst the elderly, the use of herbal treatments is greater than has been estimated. Therefore, when family practitioners observe lesions particularly on joint surfaces, the use of plant extracts must be questioned.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85599594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xanthogranulomatous inflammation of the ovary with the uterine adenomatoid tumor in a patient with diabetes mellitus: A case report","authors":"Ö. Şengül, Gülcan Dauletkazin, L. Keskin, S. Orhun, F. Avşar","doi":"10.29333/EJGM/81732","DOIUrl":"https://doi.org/10.29333/EJGM/81732","url":null,"abstract":"Adenomatoid tumor of the uterus and xanthogranulomatous inflammation of the ovary are very rare lesions. This case report is to document both lesions in a patient with diabetes mellitus. A postmenopausal patient , ultrasonographic examination revealed 72*42mm cystic lesion in adnexial region and 120*40mm sized collection of intraabdominal fluid .The patient had diabetes mellitus for 6 years. Total abdominal hysterectomy and bilateral salphingooferectomy were performed. The pathology report came out as uterin adenomatoid tumor, ovarian xanthogranulomatous inflammation, abcess formation in the same fallopian tube. This is the first reported case, both lesions in the same patient. Immunesupression is the common etiologic factor for both lesions. Uncontrolled diabetes mellitus resulting in impaired leukocyte function and immunocompromised status may be predisposing factors. Preoperative diagnosis of both adenomatoid tumor and xantogranulamatous inflammation may be important in avoiding aggressive surgical intervention but mostly the exact diagnosis can only be made by pathologic examination.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76759586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoracic manifestations of Gynecological tumors: Airway and lung parenchymal involvement commoner in endometrial and ovarian cancers while pleural and interstitial involvement is predominant in cervix malignancies","authors":"Patil Shital, M. Mirza, M. Kadam","doi":"10.29333/EJGM/81728","DOIUrl":"https://doi.org/10.29333/EJGM/81728","url":null,"abstract":"Introduction:The thorax is a frequent site of metastasis from numerous non-pulmonary cancers. Intrathoracic metastatic disease may manifest in a variety of forms, including solitary or multiple pulmonary nodules, endobronchial tumor, lymphangitic carcinomatosis, or a pleural effusion.Material and Methods:This is muticentric, observational study conducted in Pulmonary Medicine, MIMSR medical college & Venkatesh chest hospital and critical care center, Latur during June 2012 to November 2016 to observe various thoracic manifestations of gynecological malignancies. Total 2300 cases of various gynecological malignancies were screened and finally 330 cases showing various thoracic manifestations were enrolled after subjecting those cases to inclusion and exclusion criteria. All study cases were subjected to chest radiological investigations and histopathological investigations whenever necessary to diagnose metastatic disease. Hospital’s ethical committee & IRB approval has been taken and written informed consent of patient was taken before enrollment.Results:Screened total 2000 cases of gynecological malignancies (ovary, endometrium, cervix & benign ovarian tumors) and selected 330 cases with various metastatic thoracic manifestations. Malignant gynecological tumors including endometrial, cervical & ovarian cancers predominantly observed in above 50 years of age while benign ovarian and uterine tumors in below 50 years of age (p<0.00001). In study of 100 cases of ovarian cancer with thoracic manifestation, documented lung mass lesion as predominant involvement in 38% cases, pleural effusion in 19% cases & lymphangitic carcinomatosis in 11 % cases. In study of 100 cases of endometrial cancer with thoracic manifestation, documented lung mass lesion as predominant in 58% cases, endobronchial metastasis in 16% cases & lymphangitic carcinomatosis in 6 % cases. In study of 100 cases of cervical cancer with thoracic manifestation, documented lymphangitic carcinomatosis as predominant in 36 % cases, pleural effusion in 26% cases & endobronchial metastasis in 5 % cases. Lung metastasis and endobronchial involvement documented predominantly in ovarian and endometrial malignancies while pleural effusion and lymphangitic carcinomatosis documented predominantly in cervical malignancies (p<0.00001). Involvement of airway (endobronchial metastasis) and lung parenchymal mass lesion predominantly documented in endometrial malignancies; lung parenchymal (mass lesion) with lymphangitic carcinomatosis in ovarian malignancies and predominantly pleural involvement with lymphangitic carcinomatosis documented in cervical malignancies (p<0.003).Conclusions:Thoracic metastatic manifestations of gynecological tumors are underdiagnosed & less reported in clinical practice because of lack of suspicion & use of modern radiological techniques to diagnose these lesions. Cases with gynecological tumors with respiratory symptoms should be evaluated with all possible conventional & ad","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75642255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory cytokines and immune system response to weight reduction in obese patients with type 2 diabetes mellitus","authors":"S. El-Kader, M. S. Al-dahr","doi":"10.29333/EJGM/81727","DOIUrl":"https://doi.org/10.29333/EJGM/81727","url":null,"abstract":"Introduction:Systemic inflammation and activated immune system response are common features in obese patients with non-insulin dependent diabetes mellitus (NIDDM) as obesity-induced NIDDM represents a burden for healthcare systems worldwide. However, there is a strong association between BMI and the human immune system and systemic inflammation among obese patients with NIDDM.Material and Methods:Eighty obese patients with NIDDM participated in this study, their age ranged from 41-52 years and their BMI ranged from 31-36 kg/m2. All Subjects were included in two groups: The first group received life style modification in the form of treadmill aerobic exercises in addition to diet control where, the second group received no therapeutic intervention. Parameters of CD4 and CD8 cells count were quantified, IL-6, TNF-α, leptin and body mass index (BMI) were measured before and after 3 months at the end of the study.Results:The mean values of CD4 and CD8 cells count were significantly increased, where mean values of TNF-α, IL-6, IL-8 and body mass index (BMI) were significantly decreased in group (A). While group (B) showed non-significant changes in these parameters. Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study.Conclusions:Within the limit of this study, life style modification modulates systemic inflammation and immunological parameters among obese patients with NIDDM.Objecttive:This study aimed to examine effects of weight reducing program on selected immune and systemic inflammation parameters among obese patients with NIDDM.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74368175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sociodemographic and clinical characteristics of patients with violence attempts with psychotic disorders","authors":"S. Korkmaz, L. Turhan, Sadullah Sağlam, M. Atmaca","doi":"10.29333/EJGM/81738","DOIUrl":"https://doi.org/10.29333/EJGM/81738","url":null,"abstract":"Introduction:The objective of the study is to compare the socio-demographical characteristics of patients with psychotic disorders that engage or dont engage in violent behavior against individuals, and to conduct a research on the degree of affinity of the victims of violence with the patient and on factors that could affect violence.Material and Methods:All patients (151 patients) that were treated during the last year, diagnosed with psychotic disorder. The patients were compared in two groups; these who engaged in violent acts and these who did not. Furthermore, patients in the violent group were separated into two groups; one consisting of the patients who engaged in violent behavior against immediate family members, hence the immediate violence group, and the patients who didn’t engage in violence against immediate family members, hence the distant violence group.Results:It was determined that 56% of the patients with psychotic disorder have attempted violence, out of which 75% were engaged in violent behavior against their immediate relatives. It was determined that patients who attempted violence were primarily those diagnosed with paranoid schizophrenia and chronic schizophrenia. It was observed that patients that did not receive regular psychiatric therapy attempted in violence more than others.Conclusions:Patients with active psychotic symptoms should be treated in early stages and precautions should be taken against to decrease attempts at violence.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89811684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urine hydroxyproline correlates with progression of spasticity in cerebral palsy","authors":"O. Htwe, S. Lloyd, M. Ng, A. Richard, A. Rashid, A. S. Naicker, S. Ibrahim","doi":"10.29333/EJGM/81726","DOIUrl":"https://doi.org/10.29333/EJGM/81726","url":null,"abstract":"Introduction:Most Cerebral Palsy (CP) patients develop muscle spasticity which is characterized by jerky movements and muscle and joint stiffness. This increase of muscle stiffness in spastic CP has been correlated with the accumulation of collagen in the muscle as detected by the increase in muscle hydroxyproline, a major component of collagen.Material and Methods:This was a cross sectional comparative study, conducted in the tertiary hospital, Malaysia from June’2012 to December’2014. Children with spastic CP (6 to 18 years) who were scheduled for muscle/tendon lengthening as part of the on going management and children with pure spasticity were included in this study. Normal children who are aged and sex matched to the CP children were included. Muscle biopsy and urine samples were collected for MH and UH analysis respectively.Results:A total of 48 children, aged 6 to 18 years (17 normal; 16 spastic CP without contracture, 15 spastic CP with contracture) were included in this study. Muscle biopsy (only for CP children with contracture) and urine samples were collected. A significant negative correlation was noted between the MH (261.894±69.077ng/ml) and UH (13.266±7.999ng/ml) levels (p=0.031). There was a statistically significant correlation between UH levels and the MAS score (p=0.01), and GMFCS score (p=0.015).Conclusions:UH quantification may be an objective tool to estimate the severity and progression of spasticity in CP.Objectives:The objective of the study is to determine if there is any correlation between muscle and urine hydroxyproline levels in spastic CP. Further, to determine if Urine Hydroxyproline levels are different between spastic CP with and without contracture. Finally to determine if UH levels can be correlated with severity of CP as determined by Modified Ashworth Scale (MAS) and Gross Motor Function Classification System (GMFCS) scores.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84795816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}