Inflammatory cytokines and immune system response to weight reduction in obese patients with type 2 diabetes mellitus

S. El-Kader, M. S. Al-dahr
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Abstract

Introduction:Systemic inflammation and activated immune system response are common features in obese patients with non-insulin dependent diabetes mellitus (NIDDM) as obesity-induced NIDDM represents a burden for healthcare systems worldwide. However, there is a strong association between BMI and the human immune system and systemic inflammation among obese patients with NIDDM.Material and Methods:Eighty obese patients with NIDDM participated in this study, their age ranged from 41-52 years and their BMI ranged from 31-36 kg/m2. All Subjects were included in two groups: The first group received life style modification in the form of treadmill aerobic exercises in addition to diet control where, the second group received no therapeutic intervention. Parameters of CD4 and CD8 cells count were quantified, IL-6, TNF-α, leptin and body mass index (BMI) were measured before and after 3 months at the end of the study.Results:The mean values of CD4 and CD8 cells count were significantly increased, where mean values of TNF-α, IL-6, IL-8 and body mass index (BMI) were significantly decreased in group (A). While group (B) showed non-significant changes in these parameters. Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) at the end of the study.Conclusions:Within the limit of this study, life style modification modulates systemic inflammation and immunological parameters among obese patients with NIDDM.Objecttive:This study aimed to examine effects of weight reducing program on selected immune and systemic inflammation parameters among obese patients with NIDDM.
炎症细胞因子和免疫系统对肥胖2型糖尿病患者体重减轻的反应
全身性炎症和激活的免疫系统反应是肥胖非胰岛素依赖型糖尿病(NIDDM)患者的共同特征,因为肥胖引起的NIDDM是全球卫生保健系统的负担。然而,在肥胖的NIDDM患者中,BMI与人体免疫系统和全身性炎症有很强的相关性。材料与方法:80例NIDDM肥胖患者参与本研究,年龄41-52岁,BMI 31-36 kg/m2。所有受试者被分为两组:第一组在饮食控制的基础上进行跑步机有氧运动,改变生活方式;第二组不进行任何治疗干预。在研究结束3个月前后分别测定CD4、CD8细胞计数、IL-6、TNF-α、瘦素和体重指数(BMI)。结果:CD4、CD8细胞计数平均值显著升高,其中TNF-α、IL-6、IL-8、BMI平均值显著降低,而B组无显著变化。也;研究结束时(A)组和(B)组所调查参数的平均水平有显著差异。结论:在本研究范围内,生活方式改变可调节肥胖NIDDM患者的全身炎症和免疫参数。目的:本研究旨在探讨减肥方案对肥胖NIDDM患者免疫和全身炎症参数的影响。
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