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Levels of circulating adipokines and their relation with glycemic control and insulin resistance in Saudi patients with non-alcoholic fatty liver disease 沙特非酒精性脂肪肝患者循环脂肪因子水平及其与血糖控制和胰岛素抵抗的关系
European journal of general medicine Pub Date : 2017-12-12 DOI: 10.29333/EJGM/81739
O. Al-Jiffri, F. M. Al-Sharif
{"title":"Levels of circulating adipokines and their relation with glycemic control and insulin resistance in Saudi patients with non-alcoholic fatty liver disease","authors":"O. Al-Jiffri, F. M. Al-Sharif","doi":"10.29333/EJGM/81739","DOIUrl":"https://doi.org/10.29333/EJGM/81739","url":null,"abstract":"Introduction:Non-alcoholic fatty liver disease (NAFLD) is a prevalent condition associated with obesity and insulin resistance (IR). Adipokines include fat-secreted proteins such as leptin or adiponectin and fat- or liver-derived cytokines such as tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) are considered to play an important role in the pathogenesis of the metabolic syndrome, including NAFLD.Material and Methods:One hundred Saudi patients with NAFLD (45 males and 55 females) with NAFLD diagnosed by ultrasonographic findings, our group includes one gender, age and body mass index (BMI) matched hundred healthy volunteers. Adiopkines and parameters of glucose control of all participants were detected.Results:Serum glucose, insulin, aspartate aminotransferase(AST), alanine aminotransferase (ALT), aspartate aminotransferase /alanine aminotransferase ratio (AST/ALT), serum levels of total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C), serum TNF-α and L-6 levels were significantly higher in patients with NAFLD when compared to control group. However, serum high density lipoprotein cholesterol (HDL-C) and adiponectin levels were significantly lower in patients with NAFLD when compared to control group. Moreover, serum levels of adipokines showed an association with insulin resistance.Conclusions:Within the limit of this study non-alcoholic fatty liver disease is associated with adipokines alteration that is correlated with abnormal glucose control and insulin resistance.Objective:The present study aimed to explore the role of adipokines in the pathogenesis of NAFLD and correlate them with glucose control.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80238837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Angiolymphoid hyperplasia with eosinophilia of the maxillary sinus and orbit 血管淋巴样增生伴上颌窦和眼眶嗜酸性粒细胞增多
European journal of general medicine Pub Date : 2017-12-12 DOI: 10.29333/EJGM/81744
I. Emre, E. Aksoy, Ö. Ünal
{"title":"Angiolymphoid hyperplasia with eosinophilia of the maxillary sinus and orbit","authors":"I. Emre, E. Aksoy, Ö. Ünal","doi":"10.29333/EJGM/81744","DOIUrl":"https://doi.org/10.29333/EJGM/81744","url":null,"abstract":"Angiolymphoid hyperplasia with eosinophilia (ALHE) is an inflammatory disorder characterized by benign vasoproliferative lesions. Although these lesions are typically found around the ear and external auditory canal, there are several studies that present cases with ocular involvement. In this report we present the first case of ALHE with ocular and sinus involvement in Turkish literature.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77019857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Thoracic application of multi-detector CT: A pictorial essay 多层螺旋CT在胸部的应用:一篇图片文章
European journal of general medicine Pub Date : 2017-12-12 DOI: 10.29333/EJGM/81740
H. Kalkan, K. Ödev, N. Poyraz, N. Gormus
{"title":"Thoracic application of multi-detector CT: A pictorial essay","authors":"H. Kalkan, K. Ödev, N. Poyraz, N. Gormus","doi":"10.29333/EJGM/81740","DOIUrl":"https://doi.org/10.29333/EJGM/81740","url":null,"abstract":"Multi-detector CT (MDCT) has considerable advantage over single-detector helical CT in the form of the shorter acquisition time, greater coverage and superior image resolution. It can be used to systematically evaluate the cardiovascular anatomy, morphologic features of thoracic vessels such as aorta, systemic veins and pulmonary vessels and relationship between the upper lobe bronchi and pulmonary arteries, coronary artery, valves, systemic veins. In diffuse lung diseases, this technique can increase nodule detection and help differentiate between small nodules and vessels. MDCT with three-dimensional (3D) volume rendering provides a unique perspective on thoracic anatomy and disease. MDCT allows shorter acquisition times, greater coverage and superior image resolution. In vascular imaging, this technique provides image quality that equals or surpasses that of conventional angiography. Its use has expanded to aid in diagnosis and surgical planning. In this article we present a pictorial review of the current applications of MDCT in diseases of the thorax.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79674039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Herpes zoster infection after an uncomplicated cataract surgery: A case report 单纯白内障手术后带状疱疹感染1例
European journal of general medicine Pub Date : 2017-12-12 DOI: 10.29333/EJGM/81743
Nursen Oncel-Acir, Hamiyet Solmaz, Servet Cetinkaya, C. Savaş, Z. Dadaci, M. Borazan
{"title":"Herpes zoster infection after an uncomplicated cataract surgery: A case report","authors":"Nursen Oncel-Acir, Hamiyet Solmaz, Servet Cetinkaya, C. Savaş, Z. Dadaci, M. Borazan","doi":"10.29333/EJGM/81743","DOIUrl":"https://doi.org/10.29333/EJGM/81743","url":null,"abstract":"Herpes zoster is an acute viral infection characterized by painful dermatomal vesicular eruption on an erythematous base. It results from reactivation of latent varicella\u0000zoster virus infection that has persisted in dorsal root ganglia. The disease is commonly encountered in elderly and immunocompromised patients. In the current report,\u0000we have presented a 70-year-old woman who developed herpes zoster infection on her left subpectoral-dorsal site following uncomplicated cataract surgery. The\u0000patient was consulted with dermatology clinic and treated successfully.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72635867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Metoclopramide-induced acute dystonic reaction misinterpreted as conversion disorder and seizure 甲氧氯丙胺引起的急性肌张力障碍反应被误解为转换障碍和癫痫发作
European journal of general medicine Pub Date : 2017-12-12 DOI: 10.29333/EJGM/81746
Betul Akbuga-Ozel, G. Aksel, Elif Kilicli, Murat Muratoglu, C. Kavalci, B. Gulalp, A. Kayipmaz
{"title":"Metoclopramide-induced acute dystonic reaction misinterpreted as conversion disorder and seizure","authors":"Betul Akbuga-Ozel, G. Aksel, Elif Kilicli, Murat Muratoglu, C. Kavalci, B. Gulalp, A. Kayipmaz","doi":"10.29333/EJGM/81746","DOIUrl":"https://doi.org/10.29333/EJGM/81746","url":null,"abstract":"Metoclopramide, an antiemetic, is the most common cause of drug-induced dystonic reactions.\u0000\u000020-year-old female patient, complaining of involuntary bilateral upward medial deviation of the eyes, generalized muscle contractions and uncontrollable cry was brought into the emergency department(ED) by an ambulance. The diagnosis of the ambulance crew was conversion or seizure. The patient has all of dystonic reaction symptoms, including facial, neck, back, and extremity spasms, opisthotonus, oculogyric crisis, torticollis, trismus. The history revealed 40 mg of metoclopramide intake. Biperiden (5 mg) was infused in 100 ml saline. Symptoms were completely resolved. She was discharged from the ED.\u0000\u0000Drug-induced dystonic reactions can be confused with conversion, seizures, encephalitis, tetanus and hypocalcemic tetany. It is important for emergency physicians to know the drugs that may have dystonic reaction as potential side effects, recognize the clinical presentation of drug-induced dystonic reactions, and properly manage them in the ED.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74934320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Meckel Gruber syndrome: A case report with review of literature 梅克尔-格鲁伯综合征1例报告并文献复习
European journal of general medicine Pub Date : 2017-12-12 DOI: 10.29333/EJGM/81741
Saime Sundus-Uygun, M. Sivri, Ahmet Topsakal, Ahmet Hakan Dikener, H. Soylu, A. Annagür
{"title":"Meckel Gruber syndrome: A case report with review of literature","authors":"Saime Sundus-Uygun, M. Sivri, Ahmet Topsakal, Ahmet Hakan Dikener, H. Soylu, A. Annagür","doi":"10.29333/EJGM/81741","DOIUrl":"https://doi.org/10.29333/EJGM/81741","url":null,"abstract":"Meckel-Gruber syndrome, which is firstly described by Friedrich Meckel and Georg B. Gruber, is an autosomal recessive disorder that is characterized triad of occipital encephalocele, bilateral renal dysplasia and polydactyly. Because of the genetic heterogeneity, multiple organs can be affected. The worldwide incidence varies from 1 in 13,250 to 1 in 140,000 live births. We have reported a male baby born at 37-week gestation, who has occipital encephalocele, polydactyly and cystic dysplasia of both kidneys. As a result of these clinical findings, Meckel-Gruber Syndrome is suspected for his baby. This study is presented to draw attention to the Meckel Gruber Syndrome which has high risk of recurrence and early diagnosis by ultrasonographic screening can be confident.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80267047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients 沙特丙型肝炎病毒患者的黏附分子和炎症标志物
European journal of general medicine Pub Date : 2017-12-10 DOI: 10.29333/EJGM/81737
O. Al-Jiffri
{"title":"Adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients","authors":"O. Al-Jiffri","doi":"10.29333/EJGM/81737","DOIUrl":"https://doi.org/10.29333/EJGM/81737","url":null,"abstract":"Introduction:Currently, about 2% of population are affected with hepatitis C worldwide, chronic hepatitis C (CHC) is the major cause of hepatic cirrhosis and referral for liver transplant. However, there is a high need for noninvasive methods for assessment of hepatocellular damage.Material and Methods:One hundred patients with chronic hepatitis C virus infection(64 males and 36 females, their age ranged from 28 to 53 years with circulating anti-HCV antibodies were equally categorized into two study groups: patients with CHC and patients with liver cirrhosis (LC). Also, one fifty healthy subjects were included as healthy controls. Serum alanine aminotransferase (ALT), soluble intercellular adhesion molecule1 (sICAM-1); Soluble vascular adhesion molecule 1(sVCAM-1); Soluble E-selectin(s-E-selectin) and Tumor necrosis factor-alpha (TNF-α) were assayed for all participantsResults:We observed elevation with regard to the healthy controls group in the parameters of ALT, sICAM-1, sVCAM-1, s-E-selectin and TNF-α for patients with CHC and patients with liver cirrhosis (LC). Also, a significant positive correlation between serum TNF-α, sICAM-1, sVCAM-1 and ALT values was detected.Conclusions:In conclusion, our results confirm that, in patients with chronic virus hepatitis and liver cirrhosis there is a significant positive correlation between serum TNF-α, sICAM-1, sVCAM-1 and ALT values. These findings suggest that serum TNF-α levels could be used as a sensitive predictor of liver inflammation, while serum ICAM-1 can be considered as a marker of hepatic necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator for the severity of liver cirrhosis.Objective:The purpose of this study was to determine the strength of the association between adhesive molecules and inflammatory markers among hepatitis C virus Saudi patients.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87251945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Extremely high serum ferritin level in a patient with Hemophagocytic Syndrome and Adult-Onset Still's disease 吞噬血细胞综合征合并成人发病斯蒂尔氏病患者血清铁蛋白水平极高
European journal of general medicine Pub Date : 2017-08-08 DOI: 10.29333/EJGM/81893
G. Sargin, T. Senturk, I. Yavaşoğlu, Firuzan Kacar-Doger
{"title":"Extremely high serum ferritin level in a patient with Hemophagocytic Syndrome and Adult-Onset Still's disease","authors":"G. Sargin, T. Senturk, I. Yavaşoğlu, Firuzan Kacar-Doger","doi":"10.29333/EJGM/81893","DOIUrl":"https://doi.org/10.29333/EJGM/81893","url":null,"abstract":"Hemophagocytic syndrome (HS) and Adult-onset Still’s disease (AOSD) are both rarely systemic inflammatory disorders. It may be difficult to differentiate these inflammatory disorders from each other. There are some signs that may help clinicians in the diagnosis such as high ferritin levels for AOSD, and leukopenia, thrombocytopenia, hypertriglyceridemia for HS. Hemophagocytic syndrome secondary to Adult-onset Still’s disease was reported rarely in literature. In this article, we aimed to report a patient of 65-year old female diagnosed with HS and AOSD with extremely high serum ferritin levels.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82324568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Atypical location of extracardiac myxoma: a case report 心外黏液瘤位置不典型1例
European journal of general medicine Pub Date : 2017-08-07 DOI: 10.29333/EJGM/81891
S. Pehlivan, R. Akçan, M. Ş. Yıldırım, Asude Gökmen, Mehtap Yondem
{"title":"Atypical location of extracardiac myxoma: a case report","authors":"S. Pehlivan, R. Akçan, M. Ş. Yıldırım, Asude Gökmen, Mehtap Yondem","doi":"10.29333/EJGM/81891","DOIUrl":"https://doi.org/10.29333/EJGM/81891","url":null,"abstract":"Cardiac myxomas are mostly arising from interatrial septum, particularly from fossa ovalis, back and front atrial wall and appendix. However, 10% of myxomas arise from atypical locations. This report presents a rare case of atypical location of extracardiac myxoma in a case of sudden death.\u0000\u0000A 43-year old female suddenly dies at home. At autopsy, three masses attached each other were observed in pericardial fat tissue localized between right atrium, vena cava superior wall, and right ventricle. Three masses, as a lobulated single mass, were 7x2x1 cm, 5x5x2 cm, 3x2x0.5 cm in size, respectively. Masses were observed to surround right coronary artery for a segment of 7 cm. Cardiac dissection revealed that mass infiltrates epicardial site of right atrium and ventricle wall but not infiltrated to myocardium and heart cavities. Histopathological and immunohistochemical findings were compatible with a rarely seen atypically localized extracardiac myxoma on right atrial epicardium.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90808012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A case report of primary tuberculosis of the tongue 原发性舌结核1例报告
European journal of general medicine Pub Date : 2017-08-06 DOI: 10.29333/ejgm/81889
C. Korkmaz, M. Daye, T. Teke, H. Toy, Eda Haşal, D. M. Yavşan
{"title":"A case report of primary tuberculosis of the tongue","authors":"C. Korkmaz, M. Daye, T. Teke, H. Toy, Eda Haşal, D. M. Yavşan","doi":"10.29333/ejgm/81889","DOIUrl":"https://doi.org/10.29333/ejgm/81889","url":null,"abstract":"At present, the rate of extrapulmonary tuberculosis is gradually increasing among all tuberculosis cases. The secondary tuberculosis of oral cavity represents 0.2-1.5% of all cases with extrapulmonary tuberculosis. Although incidence of oral lesions secondary to pulmonary tuberculosis ranges from 0.4% to 1.5%, primary tuberculosis of the tongue occurs very rare, and it is published only as isolated case reports. A male patient presented to our dermatology clinic with complaints of painful ulcerated white plaques on the tip of his tongue lasting for three months, and an excisional biopsy showed granulomatous inflammation with caseification necrosis. Pulmonary and systemic examination showed no evidence of pulmonary or other extra-pulmonary tuberculosis, and he was initiated therapy for diagnosis of primary tuberculosis of the tongue. We found that the lesion completely resolved during the follow up visit after 1 month. Primary tuberculosis of the tongue should be for differential diagnosis of resistant painful oral lesions.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84291628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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