Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects

S. El-Kader, O. Al-Jiffri
{"title":"Coagulation, fibrinolytic and cytokines parameters response to weight reduction in obese subjects","authors":"S. El-Kader, O. Al-Jiffri","doi":"10.29333/EJGM/81730","DOIUrl":null,"url":null,"abstract":"Introduction:Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation.\nObjective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients.Material and Methods:One hundred obese subjects of both genders (mean age 46.72± 3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m2. Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months.Results:Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-α), Interleukin – 6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA:Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05).Conclusions:weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.","PeriodicalId":12017,"journal":{"name":"European journal of general medicine","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of general medicine","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29333/EJGM/81730","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5

Abstract

Introduction:Background: Obesity is a major risk factor for developing cardiovascular disorders due to increased platelets count and platelets activation. Objective: The aim of this study was to measure the influence of weight loss on the coagulation and fibrinolysis parameters among obese patients.Material and Methods:One hundred obese subjects of both genders (mean age 46.72± 3.13 year) selected from the Internal Medicine Department at King Abdul Aziz University Teaching Hospital, their body mass index (BMI) ranged from 32 to 36 Kg/m2. Participants enrolled randomly into two study groups; the first group (A) received aerobic exercises and diet regimen for three months, while the second group (B) received no exercise training or diet regimen for three months.Results:Mean values of von Willbrand factor antigen (vWF-Ag), fibrinogen, plasminogen activator inhibitor-1 antigen (PAI-1:Ag) and plasminogen activator inhibitor-1 activity (PAI-1:Ac), tumor necrotic factor-alpha (TNF-α), Interleukin – 6 (IL-6) and body mass index (BMI), while the mean values of partial thromboplastin time (PTT), prothrombin time (PT), tissue plasminogen activator antigen (tPA:Ag) and tissue plasminogen activator activity (tPA:Ac) increased significantly after 3 months in group (A) as a result of weight reduction program. However, the mean values of all investigated parameters of group (B) had no significant changes. Moreover, comparison between both groups had statistical significant differences in all investigated parameters at the end of the study (P<.05).Conclusions:weight reduction program modulates systemic inflammation, fibrinolytic and coagulation of obese subjects.
凝血、纤溶和细胞因子参数对肥胖受试者体重减轻的反应
背景:由于血小板计数增加和血小板活化,肥胖是发生心血管疾病的主要危险因素。目的:探讨减肥对肥胖患者凝血和纤溶参数的影响。材料与方法:选取阿卜杜勒·阿齐兹国王大学教学医院内科肥胖患者100例,平均年龄46.72±3.13岁,体重指数(BMI) 32 ~ 36 Kg/m2。参与者被随机分为两个研究组;第一组(A组)接受有氧运动和饮食方案三个月,第二组(B组)不接受运动训练和饮食方案三个月。结果:血友病因子抗原(vWF-Ag)、纤维蛋白原、纤溶酶原激活物抑制剂-1抗原(PAI-1:Ag)、纤溶酶原激活物抑制剂-1活性(PAI-1:Ac)、肿瘤坏死因子-α (TNF-α)、白细胞介素-6 (IL-6)、体重指数(BMI)的平均值,部分凝血活素时间(PTT)、凝血酶原时间(PT)、A组体重减轻3个月后,组织纤溶酶原激活物抗原(tPA:Ag)和组织纤溶酶原激活物活性(tPA:Ac)显著升高。而B组各调查参数的平均值无明显变化。研究结束时,两组间比较,各调查参数差异均有统计学意义(P< 0.05)。结论:减肥计划可调节肥胖受试者的全身炎症、纤溶和凝血。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信