European Journal of Ophthalmology最新文献_第7页

Comparing the outcome of delayed postoperative versus intraoperative mitomycin C use in trabeculectomy: A randomized control trial. 比较小梁切除术中延迟术后与术中使用丝裂霉素C的结果：一项随机对照试验。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-03-23 DOI: 10.1177/11206721251327650

Ashok Kumar Singh, Natasha Gautam, Faisal Thattaruthody, Madhuri Akella, Srishti Raj, Sushmita Kaushik, Surinder Singh Pandav

{"title":"Comparing the outcome of delayed postoperative versus intraoperative mitomycin C use in trabeculectomy: A randomized control trial.","authors":"Ashok Kumar Singh, Natasha Gautam, Faisal Thattaruthody, Madhuri Akella, Srishti Raj, Sushmita Kaushik, Surinder Singh Pandav","doi":"10.1177/11206721251327650","DOIUrl":"10.1177/11206721251327650","url":null,"abstract":"PurposeTo compare the effect of delayed postoperative mitomycin C (MMC) application on surgical outcome and bleb morphology with intra-operative application in trabeculectomy.MethodThis monocentric, unmasked randomized control trial recruited primary glaucoma patients between 18-70 years of age. They were randomized into Group I (intraoperative MMC group) and Group II (postoperative MMC group). All patients underwent standard fornix-based trabeculectomy with differences only in the MMC application step. In Group I, 0.2 mg/ml MMC was applied intraoperatively for two minutes, while in Group II, 0.01 mg (0.25 ml of 0.04 mg/ml) of MMC was injected 7-14 days postoperatively above the bleb. The primary outcome was surgical success, whereas the secondary outcome measures were rate of complications and bleb morphology. Complete and qualified success was defined as intraocular pressure (IOP) between 6-21 mm Hg without and with ≤2 anti-glaucoma medications (AGMs).ResultsFifty-six eyes (31 in Group I and 25 in Group II) were analyzed for the outcome at 18 months follow-up. Surgical success was comparable (70.9% vs 68%) (p = 0.811) between the groups. There were higher incidences of hypotony (41.9% vs 36%) in Group I. Incidences of persistent-hypotony (p = 0.032) and late-hypotony (p = 0.127) were higher in Group I. Two eyes developed hypotony maculopathy in Group I, while none in Group II. The blebs in Group I were more avascular, cystic and developed thinning, while those in Group II were diffuse and shallow.ConclusionsDelayed postoperative MMC application may be as effective as standard trabeculectomy with MMC in lowering IOP with a lower rate of complications.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1666-1674"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of physiological crystalline Lens decentration using swept source OCT. 扫描源OCT定量生理晶状体分散。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-16 DOI: 10.1177/11206721251332759

Peter Laubichler, Haidar Khalil, Theresa Höftberger, Sophia Reifeltshammer, Klemens Waser, Leon Pomberger, Nino Hirnschall, Matthias Bolz

{"title":"Quantification of physiological crystalline Lens decentration using swept source OCT.","authors":"Peter Laubichler, Haidar Khalil, Theresa Höftberger, Sophia Reifeltshammer, Klemens Waser, Leon Pomberger, Nino Hirnschall, Matthias Bolz","doi":"10.1177/11206721251332759","DOIUrl":"10.1177/11206721251332759","url":null,"abstract":"PurposeTo quantify the decentration of the crystalline lens in a large Austrian adult cataractous and non-cataractous cohort and to predict decentration using biometric parameters.SettingKepler University Clinic, Linz, Austria.DesignRetrospective single-center study.MethodsPreoperative data sets from a cataractous population acquired between 2020 and 2022 were analyzed in this study. Measurements included optical biometry (IOLMaster 700, Carl Zeiss Meditec AG, Germany) as well as anterior segment optical coherence tomography (CASIA-2, Tomey, Japan). Both individual and bilateral analysis of decentration was performed. For decentration prediction, a machine learning algorithm (random forest) was implemented.ResultsIn total, 4731 eyes of 2531 patients were included in this study. Overall mean decentration was 0.212 mm; 95% CI: 0.208-0.216 mm, with 5.3% of patients exceeding a decentration amount of 0.4 mm. There was a low but significant correlation with tilt (r2 = 0.29; p < 0.01), CW (r2 = 0.28; p < 0.001), lens diameter (r2 = 0.09; p < 0.001) and ACD (r2 = 0.09; p < 0.001).ConclusionA decentration amount <0.3 mm should be considered physiological.The preoperative assessment of physiological decentration and its relationship with other biometric parameters could aid in the improvement of postoperative refractive outcomes and patient satisfaction, especially in selecting premium intraocular lenses.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1562-1568"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjunctival impression cytology and tear film analysis in early-stage Parkinson's disease. 早期帕金森病的结膜印模细胞学和泪膜分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-03-19 DOI: 10.1177/11206721251330472

Ali Tezcan, Refik Oltulu, Pembe Oltulu, Ali Osman Gundogan, Selman Belviranli

{"title":"Conjunctival impression cytology and tear film analysis in early-stage Parkinson's disease.","authors":"Ali Tezcan, Refik Oltulu, Pembe Oltulu, Ali Osman Gundogan, Selman Belviranli","doi":"10.1177/11206721251330472","DOIUrl":"10.1177/11206721251330472","url":null,"abstract":"PurposeWe aimed to evaluate conjunctival impression cytology (CIC) findings, tear parameters, and ocular surface in early-stage Parkinson's patients and compare the results with the control group.MethodsThis cross-sectional comparative study included 49 early-stage Parkinson's Disease (PD) patients and 45 healthy individuals as a control group. Clinical staging of Parkinson's patients was performed according to the Hoehn-Yahr Scale. Those with stages 1 and 2 were defined as early-stage PD. Ocular surface disease index (OSDI) questionnaire, tear breakup time (TBUT), Schirmer test, and CIC were applied to the patient and control groups.ResultsThere was no significant difference between the two groups in terms of mean age and gender (p = 0.606, p = 0.357, respectively). Schirmer test and TBUT results in the PD group were significantly lower compared to the control group (p < 0.001, p < 0.001). Meanwhile, the OSDI score and CIC stage of the PD group were significantly higher than that of the control group (p < 0.001, p < 0.001).ConclusionsIn early-stage PD, decreased TBUT and Schirmer test values, conjunctival goblet cell loss, and squamous metaplasia development indicate that the ocular surface is affected. Early diagnosis of dry eye in Parkinson's patients is important for preventing complications such as ocular surface damage and visual disturbances.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1621-1626"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12381395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the macula pigment optical density by a psychophysical test in dry age-related macular degeneration. 干性老年性黄斑变性的心理物理测试评价黄斑色素光密度。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-06 DOI: 10.1177/11206721251339507

Feyza Çalış Karanfil, Emin Özmert

{"title":"Evaluation of the macula pigment optical density by a psychophysical test in dry age-related macular degeneration.","authors":"Feyza Çalış Karanfil, Emin Özmert","doi":"10.1177/11206721251339507","DOIUrl":"10.1177/11206721251339507","url":null,"abstract":"PurposeTo evaluate the macular pigment optical density (MPOD) in dry age-related macular degeneration (AMD).MethodsThis prospective study included 68 dry AMD patients and, as the control group, 91 healthy volunteers. Age, gender, family history, smoking, alcohol, hypertension, hyperlipidemia, height, weight, dietary lutein intake, and use of lutein-zeaxanthin (L-Z) were questioned. Full ophthalmic examination was performed. Color fundus photography and fundus autofluorescence (FAF) images were recorded. MPOD was measured by color perimetry (CP) every 3 months for 9 months in the dry AMD group, and 1 time at the beginning of the study in the control group. 6 mg/day lutein or 10 mg/day L and 2 mg/day Z were started in non-users.ResultsSmoking, obesity, family history, light iris color, and hyperlipidemia were seen more frequently in the AMD group. Average MPOD values in the AMD group were; 3.69 ± 1.82 (baseline), 4.74 ± 1.29 (3rd month), 4.99 ± 1.27 (6th month), and 5.02 ± 1.35 (9th month) dB, respectively. In the control group, the average MPOD was 4.97 ± 1.27 dB. At the baseline, the MPOD of the AMD group was significantly lower than the control group. Smoking, obesity, poor dietary lutein intake, light iris color, and hyperlipidemia were associated with low MPOD.DiscussionThe relationship between MPOD and AMD is controversial in the literature. Low MPOD and AMD may be related depending on our results. Quit smoking, and having a rich dietary L-Z intake are important for preventing AMD progression. The results of the CP are consistent with the other psychophysical tests.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1675-1685"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of myopic maculopathy and related factors of its subtypes and visual outcomes in a Colombian population. 哥伦比亚人群中近视黄斑病变的特征及其亚型和视力结果的相关因素

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1177/11206721251340431

María Alejandra Gómez-Rocha, Carlos Mario Rangel, Juan David Arias, Alejandro Tello, Virgilio Galvis, Sylvia J Villamizar, Sergio Mancero, Germán Mejía-Salgado

{"title":"Characterization of myopic maculopathy and related factors of its subtypes and visual outcomes in a Colombian population.","authors":"María Alejandra Gómez-Rocha, Carlos Mario Rangel, Juan David Arias, Alejandro Tello, Virgilio Galvis, Sylvia J Villamizar, Sergio Mancero, Germán Mejía-Salgado","doi":"10.1177/11206721251340431","DOIUrl":"10.1177/11206721251340431","url":null,"abstract":"PurposeTo evaluate the diagnostic and prognostic utility of the atrophy-traction-neovascularization (ATN) classification in characterizing myopic maculopathy (MM) and identifying factors influencing its subtypes and visual outcomes.Methods228 eyes (136 patients) with high myopia [spherical equivalent (SE) ≤ -6.00 diopters (D) or axial length (AL) ≥ 26.5 mm] were assessed. Ocular evaluations included optical coherence tomography and ocular biometry. MM was classified into three subtypes: myopic atrophy-maculopathy (MAM), myopic tractional-maculopathy (MTM), and myopic neovascular-maculopathy (MNM). Final corrected-distance-visual-acuity (CDVA), AL, and SE were compared between eyes with and without MM and its subtypes. Univariate and multivariate models were used to identify related factors in each subtype: moderate-severe vision impairment (final CDVA between 20/70-20/400) and blindness (final CDVA < 20/400).ResultsMM was present in 58.8% of cases, 52.2% had MAM, 27.2% MNM and 14% MNM. Notably, fifteen eyes (11.2%) exhibited traction or neovascularization without atrophy. Eyes with MM exhibited worse BCVA, more negative SE, and longer AL than those without MM (p < 0.001). AL ≥ 30 mm was related to MAM (OR = 1.51; 95% CI 1.30-3.00; p = 0.004) and MNM (OR = 9.36; 95% CI 1.56-13.08; p = 0.021). Blindness was related to aged ≥ 50 years (OR = 2.80; 95% CI 1.30-6.05; p = 0.010), MTM (OR = 1.90; 95% CI 1.80-4.80; p = 0.029), and MNM (OR = 5.60; 95% CI 2.78-15.55; p = 0.005).ConclusionThe ATN classification is valuable for diagnosing and prognosing MM, as it identifies subtypes and key factors influencing visual outcomes. Notably, tractional and neovascular changes, detected in ATN but often undetectable on fundus photography, were linked to worse visual prognosis, reinforcing its clinical relevance.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1717-1727"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathologic correlations and multimodal imaging of vitreoretinal metastasis from breast carcinoma. 乳腺癌玻璃体视网膜转移的临床病理相关性及多模态影像分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1177/11206721251340582

Andrea Montesel, Basil Suresh, Caroline Thaung, Siegfried K Wagner, Ben Kirkpatrick, Hung-Da Chou, Amit Arora, William R Tucker, Angela Rees

{"title":"Clinicopathologic correlations and multimodal imaging of vitreoretinal metastasis from breast carcinoma.","authors":"Andrea Montesel, Basil Suresh, Caroline Thaung, Siegfried K Wagner, Ben Kirkpatrick, Hung-Da Chou, Amit Arora, William R Tucker, Angela Rees","doi":"10.1177/11206721251340582","DOIUrl":"10.1177/11206721251340582","url":null,"abstract":"PurposeTo present a case of non-uveal intraocular metastatic disease originating from relapsed breast carcinoma.MethodsWe report a 67-year-old female with a history of HER2-positive breast carcinoma in remission and recent squamous cell carcinoma of the esophagus presenting with ocular symptoms. Comprehensive ophthalmic examinations and multimodal imaging were performed. Diagnostic procedures included diagnostic vitrectomy and cytology analysis.ResultsThe patient was found to have metastatic carcinoma to the vitreous and retina with an immunophenotype compatible with breast carcinoma. Neurological symptoms led to the discovery of metastatic brain lesions. The patient underwent palliative systemic treatment and stereotactic brain irradiation. Follow-up showed the progression of the ocular lesions.ConclusionThis case informs on the clinical and pathological findings of a rare non-uveal intraocular metastatic disease originating from relapsed breast carcinoma. Vitreous biopsy and multimodal imaging were required for a proper diagnosis and management and would serve as a reference for further cases.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP48-NP52"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative optical coherence tomography in glaucoma surgery with Ex-PRESS^® implant. 术中光学相干断层扫描在青光眼手术中的应用。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-20 DOI: 10.1177/11206721251340295

Irene Platas Moreno, Laura Guerrero Altares, M Pilar Martin-Gutierrez, Ignacio Jiménez-Alfaro Morote

{"title":"Intraoperative optical coherence tomography in glaucoma surgery with Ex-PRESS® implant.","authors":"Irene Platas Moreno, Laura Guerrero Altares, M Pilar Martin-Gutierrez, Ignacio Jiménez-Alfaro Morote","doi":"10.1177/11206721251340295","DOIUrl":"10.1177/11206721251340295","url":null,"abstract":"IntroductionTo present the correct placement of the Ex-PRESS® implant in the anterior chamber with the intraoperative optical coherence tomography (i-OCT) scan. To the best of our knowledge, this is the first publication to report the use of i-OCT during an Ex-PRESS® glaucoma implant procedure.Case reportWe report the case of a phakic, 48 year-old South American male with bilateral advanced pigmentary glaucoma. Our patient was being treated with dorzolamide-timolol eyedrops twice daily and bimatoprost eyedrops once daily in both eyes. Glaucomatous damage in his left eye had progressed and it was then decided to perform filtering surgery in our patient´s left eye, using a P-50 Ex-PRESS® shunt and two Ologen® collagen matrix implants. As our patient was phakic, special care was taken to avoid contact with the lens. The correct placement of both subscleral devices was confirmed with the OPMI LUMERA® 700 microscope, an i-OCT device. i-OCT scans as well as a video recording were performed throughout the surgical procedure.ConclusionI-Oct can help surgeons to locate the correct placement of implants in cases such as corneal opacification or gerontoxon. This instrument is helpful in the training of ophthalmologists. I-OCT can help surgeons to locate the correct placement of implants in cases with media opacity (such as corneal opacification or gerontoxon) or in phakic patients, where it is important to avoid lens contact. This instrument is helpful in the training of ophthalmologists.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP16-NP18"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to A triad of retinal signs in Alport syndrome: The 'stair-case' fovea, choroidal thinning and peripheral schisis. Alport综合征视网膜三联征的更正：“阶梯状”中央凹、脉络膜变薄和周围裂。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-14 DOI: 10.1177/11206721251335789

引用次数: 0

Value of MRI-based radiomics models for predicting visual outcome in patients with MOG-optic neuritis: A preliminary study. 基于mri的放射组学模型预测mog -视神经炎患者视力预后的价值：初步研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-01-28 DOI: 10.1177/11206721251315784

Buhuan Zhang, Xiaoxia Chen, Yuru Dong, Muqing Liu, Sihan Du, Wenjuan Han, Ju Ye, Guisheng Wang

{"title":"Value of MRI-based radiomics models for predicting visual outcome in patients with MOG-optic neuritis: A preliminary study.","authors":"Buhuan Zhang, Xiaoxia Chen, Yuru Dong, Muqing Liu, Sihan Du, Wenjuan Han, Ju Ye, Guisheng Wang","doi":"10.1177/11206721251315784","DOIUrl":"10.1177/11206721251315784","url":null,"abstract":"PurposeTo investigate the predictive value of MRI-based radiomics models for the recovery of visual acuity after 12 months in patients with acute phase MOG-optic neuritis(MOG-ON).Materials and MethodsClinical and MRI imaging data were collected consecutively from January 2021 to April 2022 from patients with acute stage MOG-ON, and the visual acuity of patients were followed up after 12 months. After stratified random sampling, patients were divided into training and test sets, and prediction models based on CE-T1WI, FS-T2WI, and combined CE-T1WI and FS-T2WI were developed.ResultsA total of 34 eyes were included, the visual acuity recovery group included 26 eyes, and the visual acuity non-recovery group included 8 eyes. The training set included 23 eyes (18 from the visual acuity recovery group and 5 from the visual acuity non-recovery group) and the test set included 11 eyes (8 from the visual acuity recovery group and 3 from the visual acuity non-recovery group). The differences in gender, age, proportion of patients with visual acuity recovery, and lesion length between the training and test sets were not statistically significant(P＜0.05). The CE-T1WI-based radiomics model had highest predictive efficacy for visual acuity recovery after 12 months in patients with MOG-ON (AUC = 0.917), followed by the combined CE-T1WI and FS-T2WI-based radiomics model (AUC = 0.838), while the FS-T2WI-based radiomics model had the worst predictive efficacy (AUC = 0.583).ConclusionsMRI-based radiomics models have high value in predicting visual acuity recovery after 12 months in patients with acute stage MOG-ON, especially CE-T1WI.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1738-1745"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between aqueous flare levels and anti-VEGF treatment response in wet age-related macular degeneration. 湿性年龄相关性黄斑变性患者水耀斑水平与抗vegf治疗反应的相关性。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-03-16 DOI: 10.1177/11206721251327648

Pinja Sutinen, Sohee Jeon, Piotr Kanclerz, Raimo Tuuminen

{"title":"Correlation between aqueous flare levels and anti-VEGF treatment response in wet age-related macular degeneration.","authors":"Pinja Sutinen, Sohee Jeon, Piotr Kanclerz, Raimo Tuuminen","doi":"10.1177/11206721251327648","DOIUrl":"10.1177/11206721251327648","url":null,"abstract":"PurposeTo analyze the association between aqueous flare and wet age-related macular degeneration (AMD) activity during anti-VEGF treatment using the treat-and-extend (T&E) protocol.MethodsA single-centre study consisting of 84 eyes of 84 patients with wet AMD and 17 eyes of 17 patients with dry AMD at Ophthalmology Unit, Mehiläinen Hospital, Helsinki, Finland. Aqueous flare levels were recorded with a laser flare meter. Inclusion criteria was a minimum of six anti-VEGF doses given before enrollment to the study.ResultsAqueous flare levels inversely correlated with the anti-VEGF treatment interval (R2 = 0.16, P < 0.001). In the group with a 4-6-week treatment interval the aqueous flare was 13.6 ± 8.3 photon units (pu)/ms compared to 7.9 ± 2.9 pu/ms (P = 0.008), 7.8 ± 3.5 pu/ms (P = 0.006), and 7.2 ± 3.8 pu/ms (P = 0.002) among patients with 7-9-week, 10-12-week, and 13-16-week intervals, respectively. Aqueous flare was 15.4 ± 8.5 pu/ms in the group whose treatment intervals were shortened, compared to 8.6 ± 3.8 pu/ms (P = 0.003) and 7.3 ± 3.3 pu/ms (P < 0.001) in the groups where the treatment intervals were maintained or extended, respectively. Furthermore, aqueous flare levels correlated with the macular volume (R2 = 0.07, P = 0.018). Regarding macular activity, the presence of intraretinal fluid associated with higher aqueous flare levels (13.8 ± 8.6 pu/ms) compared to those without it (8.0 ± 4.0 pu/ms; P < 0.001). Patient age, pseudophakia or the anti-VEGF agent did not associate with the aqueous flare levels.ConclusionsAqueous flare measurements correlated with wet AMD activity during anti-VEGF treatment. Aqueous flare could be used to help evaluate the state of wet AMD patients and assist in decisions regarding anti-VEGF treatment modifications.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1686-1694"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0