European Journal of Ophthalmology最新文献

{"title":"Results of two different techniques for subluxated one-piece intraocular lenses: Modified Yamane technique versus modified double-flange technique.","authors":"Mehmet Icoz, Eyüp Erkan","doi":"10.1177/11206721251353661","DOIUrl":"https://doi.org/10.1177/11206721251353661","url":null,"abstract":"<p><p>PurposeTo compare the modified Yamane (MY) technique with the modified double-flange (MDF) technique in the management of subluxated single-piece foldable intraocular lenses (IOLs).MethodsThis retrospective study was conducted on 29 eyes (group MY:17 eyes, group MDF:12 eyes). In both techniques, the subluxated IOLs were moved to the anterior chamber, and anterior vitrectomy was performed. In group MY, the IOL was extracted using an approach similar to the \"twist-and-out\" technique without enlarging the main incision.The surgery was performed by creating a scleral tunnel 2.5 mm posterior to the limbus using a 26-gauge injector.In group MDF,a 6.0 polypropylene suture was passed through the widest part of the haptic near the optical portion using a 27-gauge injector guide. Visual, refractive results and complications of the two groups were compared.ResultsBoth groups exhibited significant improvement in corrected distance visual acuity.No differences were observed between the groups in terms of spherical refraction, spherical equivalent, surgical time, or intraocular pressure values (<i>p</i> > 0.05 for all). Cylindrical refraction was -1.21 ± 0.14 D in group MY and -1.76 ± 0.25 D in group MDF(<i>p</i> = 0.03).The pseudophacodonesis score was 0.45 ± 0.15 in group MY compared to 1.21 ± 0.55 in group MDF (<i>p</i> < 0.001).Central macular thickness was similar between the two groups preoperatively, while at 6 months postoperatively, it measured 251 ± 15 μm in group MY and 274 ± 18 μm in group MDF (<i>p</i> = 0.19 and <i>p</i> = 0.01).ConclusionTo our knowledge, this study is the first to compare the MY and MDF techniques for subluxated IOLs. Both techniques showed similar efficacy and safety. However, group MY demonstrated better and more stable IOL centration.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251353661"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography angiography analysis of interocular asymmetry in hydroxychloroquine retinal toxicity.","authors":"Lidia Remolí-Sargues, Clara Monferrer-Adsuara, Belén López-Salvador, Enrique López-Sánchez, Ester Francés-Muñoz, Verónica Castro-Navarro","doi":"10.1177/11206721251354834","DOIUrl":"https://doi.org/10.1177/11206721251354834","url":null,"abstract":"<p><p>IntroductionThe purpose of our investigation was to analyze interocular asymmetry of choroidal and retinal microcirculation in patients taking hydroxychloroquine (HCQ) to deepen understanding of the pathogenic mechanism of HCQ retinal toxicity.MethodsWe conducted a retrospective study. The study included 21 patients using HCQ for over 5 years (high-risk group), 25 patients using HCQ for 5 years or less (low-risk group) and 25 healthy patients. Asymmetry index (AI) of optical coherence tomography angiography (OCTA) quantitative parameters (vessel density (VD) and foveal avascular zone (FAZ) area of superficial capillary plexus (SCP), deep capillary plexus (DCP), total capillary plexus (TCP), and choriocapillaris (CC)) in 4.5 mm × 4.5 mm cube were registered.ResultsIn the HCQ group, AI of CC VD in the central area was decreased compared to the control group, even though statistical significance was not reached (<i>p</i> value 0.053). In the high-risk group, AI of TCP VD in the foveal region was diminished compared to the low-risk group (<i>p</i> value 0.021). No differences in AI of SCP and DCP VD and FAZ area were observed between HCQ group and control group, and between high-risk and low-risk groups (<i>p</i> value >0.05).ConclusionWe demonstrated a lower AI of TCP VD in the central area in patients using HCQ for over 5 years. Thus, we suggest that HCQ may play a protective role in preserving ocular microcirculation in patients with autoimmune diseases.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251354834"},"PeriodicalIF":1.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blepharospasm management in Schwartz-Jampel syndrome: A systematic review.","authors":"Rachid Bouchikh-El Jarroudi, Kolbe Roche Fernández, Ester Casas-Gimeno, Hugo González-Valdivia, Carlos Ignacio Ortez-González, David Roche, Joan Prat-Bartomeu, Sebastian Videla","doi":"10.1177/11206721251348991","DOIUrl":"https://doi.org/10.1177/11206721251348991","url":null,"abstract":"<p><p>BackgroundBlepharospasm is one of the most limiting symptoms in patients with Schwartz-Jampel syndrome and can affect early visual development, causing amblyopia and leading to disability. There is no consensus on the optimal management of blepharospasm in these patients. This systematic review aims to evaluate the current evidence for the appropriate management strategies for blepharospasm in Schwartz-Jampel syndrome.MethodsThis was a prospective register of systematic reviews (PROSPERO)-registered (CRD42024569495), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline-adherent systematic review. Databases searched include Medline (PubMed), Scopus, and Web of Science from any time to February 1st, 2025. All scientific manuscripts published discussing the management of blepharospasm in patients with Schwartz-Jampel syndrome were included. A novel therapeutic algorithm has been developed and proposed.ResultsFrom an initial number of 59 articles, 15 of them were included. No clinical trials nor observational studies were found. All these 15 articles were case series or case reports (quality of evidence: 4 or 5), involving 21 patients. A great heterogeneity in how to manage blepharospasm in Schwartz-Jampel syndrome was gathered. Therapeutic options included oral drugs (sodium channel blockers: carbamazepine, phenytoin, and procainamide), botulinum-toxin-A, and eyelid surgery (orbicularis myectomy). The management algorithm proposal is oral sodium channel blockers as the first option and eyelid surgery as the second option treatment. Botulinum-toxin-A might be considered a therapeutic step prior to surgery.ConclusionsThe published evidence regarding management strategies for blepharospasm in Schwartz-Jampel syndrome is scarce and of low quality. Since this nosology is a very rare disease, efforts should be promoted to conduct clinical research and a consensus document for the management of blepharospasm.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251348991"},"PeriodicalIF":1.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Hirschberg enough? - A comparative study of corneal light reflex test and alternate prism cover test in measuring comitant horizontal strabismus.","authors":"Insha-E-Qudrat Tirmizi, Sardar Mohammad Ali Ayaz Sadiq","doi":"10.1177/11206721251350810","DOIUrl":"https://doi.org/10.1177/11206721251350810","url":null,"abstract":"<p><p>ObjectiveTo determine the mean difference in deviation in prism dioptres as measured by corneal light reflex test and alternate prism cover test in comitant horizontal strabismus to improve practice patterns.Materials and methodsStudy settingInstitute of Ophthalmology, Mayo Hospital, Lahore, Pakistan; Sardar Trust Eye Hospital, Lahore; The Eye Associates, Lahore, Pakistan.Study designCross-sectional study.ResultsThe study included a total of 69 patients (36 males, 33 females) aged between 16 to 68 years (mean 23.5 years), of which 48 (70%) had exotropia and 21 (30%) had esotropia. The angle of deviation for exotropia ranged from 12 to 87 prism dioptres (PD) (mean 44.23 ± 19.20 PD), while for esotropia it was from 10 PD to 104 PD (mean 47.19 ± 29.10 PD). The average difference between the angle of deviation as measured by the corneal light reflex test i.e. the Hirschberg test, compared to that by the alternate prism cover test (APCT) for severe deviations was significant (<i>p</i>-value < 0.05). The difference was also significant for severe exotropia and esotropia, as well as moderate esotropia.ConclusionThere is a statistically significant difference between the measurements obtained by the corneal light reflex test and those by the alternate prism cover test, with the corneal light reflex test being substantially less accurate. Moreover, this relationship varies with the angle of the deviation, with overestimations more likely to occur with mild deviations and underestimations with severe deviations.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251350810"},"PeriodicalIF":1.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between plasma and aqueous humor endothelin-1 levels and retinal microvascular structure in glaucoma.","authors":"Furkan Emre Söğüt, Serdar Bayraktar, Zakir Osmanov, Canan Yılmaz, Emine Şen, Ufuk Elgin","doi":"10.1177/11206721251351367","DOIUrl":"10.1177/11206721251351367","url":null,"abstract":"<p><p>PurposeTo explore the relationship between plasma and aqueous humor (AH) endothelin-1 (ET-1) levels and retinal microvascular parameters measured by optical coherence tomography angiography (OCT-A) in pseudoexfoliative glaucoma (XFG) and primary open-angle glaucoma (POAG) patients versus controls.MethodsThe plasma and AH ET-1 levels were assessed using enzyme-linked immunosorbent assay (ELISA) in 23 patients with XFG, 20 patients with POAG and 34 control subjects who underwent elective cataract surgery. Microvascular parameters in the optic disc and macula were measured by OCT-A four months after surgery. The relationship between plasma and AH ET-1 levels and OCT-A parameters was analysed.ResultsThis study included 77 eyes of 77 participants. The XFG group had higher AH ET-1 levels compared to both control (<i>p</i> = 0.009) and POAG (<i>p</i> = 0.004) groups, whereas the POAG and control groups were similar (<i>p</i> = 0.999). Negative correlation was found between AH ET-1 levels and whole, parafoveal, perifoveal superficial capillary plexus vascular density (SCP VD) (<i>p</i> < 0.05 for all) and whole, peripapillary, superior hemisphere, inferior hemisphere, inferior temporal radial peripapillary capillary vascular density (RPC VD) (<i>p</i> < 0.05 for all). The plasma ET-1 levels did not differ significantly among the groups (<i>p</i> = 0.161), and no statistically significant correlation was observed between the plasma ET-1 levels and any OCT-A parameter.ConclusionWhile plasma ET-1 levels showed no differences between groups or correlation with OCT-A parameters, elevated AH ET-1 levels in XFG and their strong correlation with OCT-A vascular parameters suggest that the intraocular effects of ET-1 may be more significant than its systemic effects in XFG pathogenesis.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351367"},"PeriodicalIF":1.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical chemotherapy for the treatment of melanocytic conjunctival tumors: An updated review.","authors":"Panagiota Tzortzi, Argyrios Tzamalis, Asimina Mataftsi, Ioannis Tsinopoulos","doi":"10.1177/11206721251351153","DOIUrl":"https://doi.org/10.1177/11206721251351153","url":null,"abstract":"<p><p>Melanocytic conjunctival tumors including conjunctival melanoma and primary acquired melanosis with atypia, are rare but aggressive, capable of local invasion, systemic spread, and recurrence despite treatment. While surgery remains the standard approach, topical chemotherapy using mitomycin C and interferon alpha-2b has emerged as an alternative. This systematic review, analyzed 22 studies encompassing 116 cases. Among these, 28 cases were treated with mitomycin C as a primary therapy achieving a 60.7% remission rate, and 48 were treated with mitomycin C as adjuvant therapy yielding a 68.8% remission rate. Interferon alpha-2b achieved 87.5% remission across primary and adjuvant applications. Overall, remission was achieved in 74.1% of cases (86 patients). Topical chemotherapy provides a non-surgical approach that treats the entire conjunctival surface eliminating reliance on precise tumor margin identification. Primary mitomycin C demonstrated efficacy in managing diffuse, superficial, and intraepithelial disease whereas adjuvant was more effective for nodular and invasive lesions. Interferon alpha-2b, associated with fewer adverse effects, is a valuable alternative, particularly in cases intolerant to mitomycin C. These findings underscore the potential of topical chemotherapy as both a primary and adjuvant option, highlighting the need for further studies to refine treatment protocols and assess long-term outcomes.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351153"},"PeriodicalIF":1.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive disc edema with rapid visual loss in a case of blastic plasmacytoid dendritic cell neoplasm.","authors":"Indu Nair, Mradula Gangwar, Manoj Soman, Alfiya Aslam, Paul Varghese, Unnikrishnan Nair R","doi":"10.1177/11206721251351158","DOIUrl":"https://doi.org/10.1177/11206721251351158","url":null,"abstract":"<p><p>IntroductionBlastic plasmacytoid dendritic cell neoplasm (BPDCN), a rare haematological tumor arising from dendritic cells presents mainly as plaque-like cutaneous lesions but can also involve bone marrow, lymph nodes, central nervous system (CNS), and other tissues.Case descriptionIn this case report we have described an interesting case of BPDCN who had received multiple cycles of chemotherapy over 6 months, presenting with sudden onset and rapidly progressing unilateral vision loss. The patient had progressive disc edema with haemorrhages and rapid vision loss in the right eye from 6/9 to loss of light perception in 3 days. Interestingly on bone marrow aspiration cytology the tumour was in remission stage but contrast MRI showed swollen optic nerve sheath, indicating tumour infiltration.ConclusionThough ophthalmic involvement in BPDCN is usually orbital, very few cases of direct ocular involvement have been reported. This case is unique as haemorrhagic disc edema has never been reported in this rare malignancy. High index of suspicion of CNS involvement should be present as this carries a very poor prognosis and patients may benefit from CNS-directed therapy if administered early.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351158"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic factors of conbercept intravitreal injection in the treatment of choroidal neovascularization secondary to pathologic myopia.","authors":"Yeqiang Shi, Hui Yao, Peng Zhang, Jun Yang, Lei Gao","doi":"10.1177/11206721251351496","DOIUrl":"https://doi.org/10.1177/11206721251351496","url":null,"abstract":"<p><p>PurposeChoroidal neovascularization secondary to pathologic myopia (PM-CNV) is an important main factor leading to decreased vision in patients with pathologic myopia. Conbercept, an anti-VEGF drug, is currently the primary treatment for PM-CNV. This study used optical coherence tomography angiography (OCTA) data to investigate the factors influencing the visual prognosis of patients with PM-CNV.MethodsData from patients with PM-CNV diagnosed in the Department of Ophthalmology of The Second People's Hospital of Jinan City from January 2019 to December 2022 were retrospectively analyzed. All patients received intravitreal injections of 0.05 ml Conbercept (0.5 mg) following a 1 + pro re nata (PRN) regimen. Patients were divided into two groups based on visual acuity at 12 months after treatment: improved (best-corrected visual acuity [BCVA] improvement > 1 line) and non-improved (BCVA improvement ≤ 1 line or reduced visual acuity). The factors BCVA after treatment were analyzed using logistic regression analysis.ResultsTwelve months after treatment, there were 77 patients in the improved group and 23 in the non-improved group. Multivariable logistic regression analysis revealed that age (odds ratio (OR) = 1.303, 95% confidence interval (CI): 1.059-1.603, <i>P</i> = 0.012), baseline BCVA (OR = 15.939, 95% CI: 2.490-102.013, <i>P</i> = 0.003), subfoveal CNV (OR = 0.055, 95% CI: 0.010-0.312, <i>P</i> = 0.001), and well-organized CNV (OR = 0.049, 95% CI: 0.009-0.276, <i>P</i> = 0.001) were independently associated with the efficacy of intravitreal injection of conbercept in patients with PM-CNV.ConclusionPoor postoperative BCVA recovery in patients with PM-CNV after conbercept intravitreal injection could be associated with age, baseline BCVA, and location and morphology of CNV.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351496"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel finding in the diagnosis of acute syphilitic posterior placoid chorioretinitis: A case report.","authors":"Federico Rissotto, Riccardo Sacconi, Gloria Oldoni, Federico Beretta, Elisabetta Miserocchi, Francesco Bandello, Giuseppe Querques","doi":"10.1177/11206721251351066","DOIUrl":"https://doi.org/10.1177/11206721251351066","url":null,"abstract":"<p><p>PurposeTo describe a case of Acute Syphilitic Posterior Placoid Chorio-retinitis characterized by a peculiar optical coherence tomography (OCT) finding.MethodsThe patient underwent comprehensive ophthalmic examination, including ultra-wide field fundus photography, fluorescein angiography, and spectral-domain OCT.ResultsThis finding was characterized by hyper-reflective lesions located between the retinal pigment epithelium and the outer plexiform layer involving almost the outer nuclear layer.ConclusionWe suggest that this finding could be a sign of outer retina inflammation related to the Syphilis infection and may be helpful in the early diagnosis of ASPCC.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351066"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restoring visual function in NAION by means of transpalpebral electrical stimulation: A case report.","authors":"Salvatore Martella, Paolo Ferri, Leonardo Colombo, Giulia Torregrossa, Emanuele Mocciardini, Jacopo Baldesi, Chiara Quisisana, Luca Rossetti","doi":"10.1177/11206721251350826","DOIUrl":"https://doi.org/10.1177/11206721251350826","url":null,"abstract":"<p><p>IntroductionNon-arteritic anterior ischemic optic neuropathy (NAION) is a major cause of vision loss in middle-aged and elderly populations, with no effective treatment currently available. Electrical stimulation (ES) has shown potential in preserving and restoring neural function in optic neuropathies. This study investigates the efficacy of transpalpebral ES in improving visual function in a patient with long-term visual impairment due to NAION.MethodsA 62-year-old male patient with sequential NAION in both eyes underwent a 60-day transpalpebral ES for 20 min daily. Visual function was assessed at baseline and after 30 and 60 days of treatment, including best-corrected visual acuity (BCVA), contrast sensitivity, visual field (VF) analysis, and microperimetry.ResultsSignificant improvements in BCVA were detected, with an overall increase of 11 ETDRS letters in the right eye and 18 in the left eye after 60 days of treatment. Contrast sensitivity also improved in both eyes. Visual field parameters, including mean deviation, pattern standard deviation and visual field index, showed notable enhancements. Microperimetry revealed increased macular sensitivity and improved fixation stability. The patient also reported subjective improvements. No adverse events were noted.DiscussionES has been shown to enhance retinal function by modulating neuronal excitability, activating neuroprotective signaling pathways, and potentially supporting neural regeneration. In our case, transpalpebral ES was associated with meaningful improvements in visual function in a patient with long-term NAION-related visual impairment. These results suggest ES as a promising approach for NAION, though further research is needed to confirm these results and optimize treatment protocols.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251350826"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}