European Journal of Ophthalmology最新文献

{"title":"Evaluating semi-automated kinetic perimetry in persons with idiopathic intracranial hypertension.","authors":"Simon J Hickman, Lucy Givens, Joanna M Jefferis, Irene M Pepper, Martin J Rhodes","doi":"10.1177/11206721251329982","DOIUrl":"10.1177/11206721251329982","url":null,"abstract":"<p><p>BackgroundThis study aimed to assess whether semi-automated kinetic perimetry (SKP) enables the quantitation and monitoring of visual field loss in persons with idiopathic intracranial hypertension (PWIIH).MethodsWe conducted a retrospective review of newly diagnosed PWIIH. We recorded baseline clinical data and optic disc modified Frisén grade from fundal photographs. The SKP software calculated the I4e and I2e isopter areas and the I4e target plotted blind spot areas. This was recorded for each eye at baseline and for each study visit for up to 1 year.ResultsBoth the baseline I4e isopter (F = 44.1, <i>p</i> < 0.001) and I2e isopter areas (F = 37.1, <i>p</i> < 0.001) were significantly related to baseline visual acuity. The baseline blind spot area was significantly related to modified Frisén grade (F = 22.0, <i>p</i> < 0.001). There was no significant linear relationship between either the I4e isopter (F = 0.06; <i>p</i> = 0.939) or I2e isopter areas (F = 0.06, <i>p</i> = 0.807) and the time since diagnosis. There was, however a significant linear decrease in mean blind spot area over time (F = 46.6, <i>p</i> < 0.001).ConclusionsThe relationships at baseline between I4e and I2e isopter areas and visual acuity show that SKP provides clinically meaningful results at presentation in PWIIH. Our results suggest that it is less useful for monitoring recovery.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1761-1766"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of MicroPulse transscleral laser therapy with the revised P3 delivery device: A randomized controlled trial.","authors":"P Connor Lentz, Isabella V Wagner, Devesh Kumar, Nithya Boopathiraj, Bryan C H Ang, Abhimanyu Ahuja, Leticia Checo, Darby D Miller, Syril Dorairaj","doi":"10.1177/11206721251340102","DOIUrl":"10.1177/11206721251340102","url":null,"abstract":"<p><p>ObjectiveTo evaluate the safety and efficacy of MicroPulse Transscleral Laser Therapy (MicroPulse TLT) with the Revised P3^® Delivery Device.DesignProspective, single-surgeon, interventional study in a tertiary hospital setting.ParticipantsSixty-two eyes of 40 patients with refractory glaucoma.MethodsAll subjects received 360-degree MicroPulse TLT treatment (2500 mW, 31.33% duty cycle) over a total of 240 s (8 sweeps; <i>n</i> = 20), 300 s (10 sweeps; <i>n</i> = 22), or 200 s (10 sweeps; <i>n</i> = 20). Participants were followed up for 6 months to assess changes in intraocular pressure (IOP), glaucoma medication burden, and best-corrected visual acuity (BCVA). Surgical success was defined as a reduction of IOP ≥ 30% from baseline and between 6-18 mmHg at last follow-up with no additional anti-glaucoma medications or secondary reinterventions.ResultsSurgical success was achieved in 72.7% (300 s group), 75.0% (240 s group), and 80.0% (200 s group) of eyes. Mean IOP was significantly reduced (<i>p</i> < 0.001) by 49.0% (300 s group), 45.66% (240 s group), and 39.8% (200 s group) at 6 months. With all groups combined, the mean number of glaucoma medications was significantly reduced by 17.8% (<i>p</i> = 0.005), and no significant changes in BCVA were observed at 6 months. Complications were minimal, including four eyes with IOP spikes, one eye with hyphema, and one eye with cystoid macular edema (CME), all of which resolved. Two eyes of the total sample (3.2%) required secondary glaucoma surgery before 6 months.ConclusionsSecond-generation MicroPulse TLT at fluence values of 154-229 J/cm² appears to be a safe and effective option for IOP reduction in refractory glaucoma.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1863-1874"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prognostic role of video head-impulse test in the clinical evaluation of chronic vestibular damage: A brief case series.","authors":"Stefano Dore, Renato Patta, Giacomo Boscia, Pasquale Viggiano, Ermete Giancipoli, Andrea Melis, Antonio Pinna","doi":"10.1177/11206721251338500","DOIUrl":"10.1177/11206721251338500","url":null,"abstract":"<p><p>IntroductionThe video Head Impulse Test (vHIT) is a valid tool in identifying acute vestibular damage (AVD) and cerebellar vertigo syndromes, but a diagnostic gap remains in identifying those patients who experience persistence of chronic vestibular symptoms. The aim of this brief study was to investigate the ability of vHIT combined with the Italian Dizziness Handicap Inventory (DHI) score to identify AVD patients who develop chronic vestibular deficiency.Case SeriesThe mean age of the 18 patients enrolled was 56 years (SD ± 12), and among them 10 (55.5%) were males. Improved gain was found in one-third of the cases (6, 33.3%); in addition, we observed that the vHIT 60 ms gain could predict the DHI value at follow-up (p = 0.007). Furthermore, the distribution of Overt and Covert saccades at follow-up between the two iDHI groups was significantly different (p = 0.025), with a greater number of patients without any type of corrective saccade in the low iDHI group. Furthermore, group 1 patients were found to have a significantly higher mean age compared to those of group 0 (p = 0.015), along with a lower vHIT gain at 60 ms at final follow-up (p = 0.062).ConclusionsThese results of our study showed that the vHIT 60 ms gain could predict the iDHI score, but the width and latency of the saccades were not correlated with iDHI at follow-up. In addition, patients with low iDHI score had not corrective saccades, while those with high iDHI score were significantly older than those with low iDHI.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP38-NP40"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of CD15 in the bulbar conjunctiva among T2DM patients with ocular surface damage.","authors":"Tetiana Zhmud, Stefano Barabino, Galyna Drozhzhyna","doi":"10.1177/11206721251327642","DOIUrl":"10.1177/11206721251327642","url":null,"abstract":"<p><p>BackgroundType 2 diabetes mellitus (T2DM) is a chronic metabolic disorder, which induces ocular surface damage due to low-grade inflammation.AimTo detect and evaluate relative epithelial expression of CD15 in bulbar conjunctiva among patients with and without T2DM based on results of conjunctival impression cytology (CIC), in order to study its role in conjunctival parainflammation related to T2DM.Materials and methodsWe conducted a prospective observational study from March 2023 to December 2023. Forty-eight T2DM patients (96 eyes) were enrolled into a study group. The control group included forty (80 eyes) age- and sex-matched healthy volunteers. All patients underwent conjunctival impression cytology (CIC) and expression of CD15 in bulbar conjunctiva.ResultsExpression of CD15 was detected on epithelial cells in 95% of samples in the study group and 15% of the controls, is statistically significant (<i>p</i> = 0.0000). Mean expression of CD was at 0.96 ± 1.28%, and it was significantly different from the study group with the same Nelson's grade - 3.81 ± 1.48% (<i>p</i> = 0.0351). CD 15 values were significantly higher between Nelson II and III in the study group (3.81 ± 1.48; 7.72 ± 1.65; <i>p</i> = 0.0000, respectively).ConclusionsThe research shows that T2DM patients are prone to increased epithelial expression of CD 15 compared to healthy controls. Relative expression of CD15 may be utilized as a potential marker to evaluate topical treatment outcomes of ocular surface damage in T2DM.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1614-1620"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory corneal melting due to IgG4-related disease: Successful management via buccal mucosal graft transplantation.","authors":"Zeynep Akgun, Derya Demir, Semiha Koroglu, Taner Akalin, Kenan Aksu, Ozlem Barut Selver","doi":"10.1177/11206721251338517","DOIUrl":"10.1177/11206721251338517","url":null,"abstract":"<p><p>PurposeTo present the first case of isolated corneal involvement in IgG4-RD, managed successfully with oral mucosal grafting due to the destructive course of the disease.Case reportA 56-year-old female one-eyed patient was referred to our clinic with a diagnosis of unresponsive infectious corneal melting. The ophthalmologic examination revealed light perception visual acuity, intense conjunctival inflammation and an infected area of approximately 4 × 5 mm with accompanying melting. Her medical history includes a diagnosis of dry eye disease that has persisted for over a decade, multiple previous corneal transplant surgeries in the right eye with similar complaints, and subsequent evisceration surgery. Her complaints in the left eye had increased over the previous six months, and she had undergone eight instances of amniotic membrane transplantation at an external medical facility. Corneal scraping, conjunctival and corneal biopsy were performed. The histopathologic examination and elevated serum IgG4 level indicated the presence of IgG4-related disease. She was referred to the rheumatology department, where immunosuppression treatment was initiated. Oral mucosal grafting was performed to address the uncontrolled melting. At the follow-up examination, the melting was successfully controlled, the inflammation regressed, and the early hypertrophy of the oral mucosal epithelium flattened over time.ConclusionThis case highlights the potential for IgG4-related disease to manifest as atypical ocular surface involvement. Dry eye secondary to the disease can exacerbate existing findings. In such instances, preserving the integrity of the globe is of the utmost importance. Therefore, oral mucosal grafting, which is known for its durability, should be considered a viable option.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP8-NP12"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous corneal patch for simultaneous bilateral perforation in Sjögren's syndrome. A case report.","authors":"Giacomo Scotti, Nicola Cardascia, Maria Gabriella La Tegola, Giacomo Boscia, Linda Pomes, Francesco Boscia, Giovanni Alessio","doi":"10.1177/11206721251340231","DOIUrl":"10.1177/11206721251340231","url":null,"abstract":"<p><p>PurposeTo present a case of simultaneous bilateral corneal perforation in a patient affected by Sjögren syndrome (SjS) successfully managed with corneal transplantation on the left eye and placing an autologous corneal patch on the right eye.ObservationsA 71-year-old woman with SjS presented at our attention complaining of pain, redness, and blurred vision in both eyes persisting for 4 days. Clinical and instrumental investigations led to the diagnosis of bilateral corneal perforation in the context of Sjögren syndrome. Therapeutic contact lenses were initially placed, followed by surgical intervention using an autologous corneal patch for the right eye and a corneal transplant for the left eye. Postoperative recovery was successful, with stable corneal condition and normal intraocular pressure observed at 3 and 6-months follow-ups.Conclusions and importanceThis case underscores the complexity of managing SjS-related ocular complications and propose the use of autologous corneal patches to minimize immune rejection risks in cases where corneal transplantation cannot be performed.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP1-NP4"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous wave transscleral cyclophotocoagulation with the slow-cooking protocol to treat refractory glaucomas.","authors":"Heloisa Andrade Maestrini, Heloisa Helena Abil Russ, Regina Cele Silveira Seixas, Marcos Balbino, Thatiana Almeida Pereira Fernandes, Núbia Vanessa Lima, Nara Lídia Vieira Lopes, Luiz Paulo Dias Mario, Taurino Dos Santos Rodrigues Neto","doi":"10.1177/11206721251335381","DOIUrl":"10.1177/11206721251335381","url":null,"abstract":"<p><p>PurposeThis study aimed to describe the results of slow-cooking transscleral cyclophotocoagulation (SC-TSCP) with diode laser in patients with refractory glaucoma.MethodsThis retrospective study included 289 eyes of 263 patients who underwent the SC-TSCP technique at the glaucoma service of Oculare Ophthalmology Hospital, Brazil, with a minimum of one year of postoperative follow-up. We analyzed intraocular pressure, number of medications, postoperative complications, visual acuity, need for additional glaucoma surgery, need for repeat sessions of SC-TSCP, and the variables influencing success rates. ​​We used three criteria to analyze the technique's success: 1) Final IOP ≤ 21 mmHg, 2) Final IOP between 6 and 21 mmHg, and 3) Reduction of at least 30% in IOP.ResultsMean IOP dropped from 37.52 (±12.12) mmHg preoperatively to 14.48 (± 7.56) mmHg at the end of the study (<i>p</i> = 0.0001). The average reduction in IOP was 23.04 (±14.00) mmHg, representing a reduction of 61.41% in IOP (<i>p</i> = 0.0001). The mean number of medications dropped from 2.98 (±1.43) to 1.79 (±1.50) (<i>p</i> = 0.0001). Complete success (without eyedrops) was achieved in 25.61%, 18.69%, and 29.41% for each success criterion, and qualified success (with or without eyedrops) was achieved in 79.58%, 68.86%, and 85.43%, respectively. Visual acuity decreased from 1.99 LogMar (Snellen 20/1954) to 2.11 LogMar (Snellen 20/2576) (<i>p</i> = 0.0001). Seventy-two eyes (24.91%) needed a second session, 15 eyes (5.19%) needed a third cyclophotocoagulation, and one eye (0.35%) needed a fourth session. The most common complications were persistent hypotony (8.65%), corneal decompensation (6.23%), loss of light perception (5.88%), and phthisis (2.77%). After cyclophotocoagulation, 86.85% of the eyes did not require additional surgical procedures for IOP control.ConclusionThe slow-cooking transscleral cyclophotocoagulation technique proved highly effective in the prolonged control of intraocular pressure in severe and refractory glaucoma and demonstrated a favourable safety profile. However, in complex and refractory cases, severe complications such as vision loss or phthisis, although rare, may occur.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1654-1665"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External limiting membrane aperture as a reliable and predictive prognostic factor in macular hole surgery.","authors":"Gian Marco Guerin, Marco R Pastore, Pier Luigi Guerin, Alberto Grotto, Leandro Inferrera, Daniele Tognetto","doi":"10.1177/11206721251334161","DOIUrl":"10.1177/11206721251334161","url":null,"abstract":"<p><p>PurposeTo evaluate the role of external limiting membrane aperture (ELMA) as a prognostic factor for the anatomical and functional outcomes of full thickness macular hole (FTMH) surgery.DesignRetrospective.Methods120 eyes of 120 patients who underwent surgery for idiopathic FTMH were enrolled. Best corrected visual acuity (BCVA) and spectral-domain optical coherence tomography (SD-OCT) scans were evaluated preoperatively and postoperatively at 3 and 12 months. Statistical analysis was performed to correlate the following preoperative parameters with 12-months postoperative BCVA and anatomical results: ELMA, apical hole diameter (AD), base hole diameter (BD), macular hole index (MHI), tractional hole index (THI), height (H), diameter hole index (DHI), hole form factor (HFF) and preoperative BCVA.ResultsPrimary successful MH closure was achieved in all the eyes. Postoperative BCVA showed a statistically significant increase from a preoperative logMAR median (IQR) value of 0.70 (0.52-1.00) to 0.18 (0.10-0.34) at 3 months and 0.16 (0.05-0.30) at 12 months. As demonstrated by ROC curves analysis, ELMA revealed to be a good predictor for 1B and 1C types of MH closure when its value was greater than 369 µm. Moreover, ELMA sizes above 369 µm were strongly associated with a postoperative BCVA less than 20/40.ConclusionsELMA appears to be a reliable prognostic factor for postoperative anatomical and functional outcome in FTMH surgery.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1854-1862"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Erratum</i> to \"Treatment of <i>Acanthamoeba</i> keratitis with high dose PHMB (0.08%) monotherapy in clinical practice: A case series\".","authors":"","doi":"10.1177/11206721241307510","DOIUrl":"10.1177/11206721241307510","url":null,"abstract":"","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP73"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma-induced corneal epithelial defects may lead to persistent epithelial defects exacerbated by prolonged use of bandage lenses.","authors":"Donghai Wu, Yuan Lin, Huping Wu, Jinhong Cai","doi":"10.1177/11206721251333590","DOIUrl":"10.1177/11206721251333590","url":null,"abstract":"<p><p>ObjectiveTo investigate the causes of corneal epithelial defects (CEDs) due to mechanical trauma and analyze the risk factors for progression to persistent epithelial defects (PEDs).MethodA retrospective analyze 241 patients (241 eyes) with CEDs caused by mechanical ocular trauma. All patients received initial treatment as outpatients at our hospital. Data collected included patients' basic information, injury causes, use of adjunctive treatments, improvement in symptoms and adverse reactions before and after treatment. Logistic regression analysis was used to explore the relationship between the causes of injury, the use of adjunctive treatments, and the occurrence of persistent corneal epithelial defects.ResultsThe study involved 241 patients: 164 males (68.1%) and 77 females (31.9%), averaging 38.06 ± 17.88 years old. The most common age groups were 31-40 years (24.1%), 41-50 years (19.9%), and 51-60 years (18.2%). The top five causes of injury were finger pokes (20.4%), impacts from plastic objects (14.6%), branch strikes (13.3%), paper cuts (8.8%), and metal scratches (8.3%). 164 patients used recombinant human growth factor (rhEGF) eye drops with an average healing time of 3.2 ± 1.3 days, while 77 did not use these drops, averaging 7.4 ± 2.2 days. Continuous use of bandage lenses was a risk factor for persistent epithelial defects (<i>P</i> < 0.001).ConclusionTreatment of CEDs caused by mechanical trauma should focus on managing ocular surface inflammation. The use of rhEGF eye drops can be an effective supplement treatment for CEDs. However, caution is needed regarding the use of bandage lenses.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1818-1823"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}