European Journal of Ophthalmology最新文献_第8页

Refractive outcomes following simultaneous silicone oil removal and ciliary sulcus intraocular lens implantation. 同时摘除硅油和植入睫状沟眼内晶状体后的屈光效果。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-10-15 DOI: 10.1177/11206721241287255

Dezhi Zheng, Zijing Huang, Zhiying Chen, Dingguo Huang, Weiqi Chen

{"title":"Refractive outcomes following simultaneous silicone oil removal and ciliary sulcus intraocular lens implantation.","authors":"Dezhi Zheng, Zijing Huang, Zhiying Chen, Dingguo Huang, Weiqi Chen","doi":"10.1177/11206721241287255","DOIUrl":"10.1177/11206721241287255","url":null,"abstract":"PurposeThis study aimed to assess the refractive outcomes following the combined intervention of silicon oil (SO) removal and ciliary sulcus intraocular lens (IOL) implantation in aphakic eyes after phacovitrectomy.MethodsA retrospective examination of medical records from patients who underwent a combined procedure of SO removal and ciliary sulcus IOL implantation from 2019 to 2022 was performed. The primary outcomes of interest included uncorrected distance visual acuity (UDVA), predictive error (PE) and mean absolute predictive error (MAE). Subgroup analyses were performed to compare outcomes between patients with and without intraoperative posterior capsulotomy.ResultsThe cohort comprised 40 eyes from 40 patients, with a mean duration of SO tamponade of 5.17 ± 1.48 months. A significant improvement in UDVA was observed from 1.58 ± 0.31 logMAR to 0.99 ± 0.31 logMAR one month postoperatively (P < 0.01). The PE was -0.73 ± 0.86 diopters (D), and the MAE was 0.90 ± 0.67 D, with 37.50% and 57.50% of cases achieving PE within ±0.5 D and ±1.0 D, respectively. No significant differences in UDVA, PE, or MAE were found between the capsulotomy and non-capsulotomy subgroups (all P > 0.05). However, a lower proportion of eyes in the capsulotomy group achieved PE within ±1.0 D compared to the non-capsulotomy group one month postoperatively (38.90% vs. 72.70%, P = 0.03).ConclusionsThe combined procedure of SO removal and sulcus IOL implantation resulted in a mild myopic shift in postoperative refraction. Intraoperative posterior capsulotomy seems to increase the lability of postoperative refractive outcomes.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1103-1108"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trends in glaucoma surgery in a tertiary hospital in Spain: 2010-2022. 西班牙一家三级医院的青光眼手术趋势：2010-2022 年。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-10-29 DOI: 10.1177/11206721241295291

Laura Morales-Fernandez, Javier Garcia-Bardera, Pilar Pérez-García, Federico Saenz-Frances, Sofia Garcia-Saenz, Jose M Martinez-de-la-Casa, Julian Garcia-Feijoo

{"title":"Trends in glaucoma surgery in a tertiary hospital in Spain: 2010-2022.","authors":"Laura Morales-Fernandez, Javier Garcia-Bardera, Pilar Pérez-García, Federico Saenz-Frances, Sofia Garcia-Saenz, Jose M Martinez-de-la-Casa, Julian Garcia-Feijoo","doi":"10.1177/11206721241295291","DOIUrl":"10.1177/11206721241295291","url":null,"abstract":"ObjectiveThis study aims to conduct an analysis glaucoma surgeries performed over a 13-year period at a tertiary hospital affiliated with the Spanish National Health System, with the goal of assessing temporal trends.MethodsThis retrospective observational study scrutinized surgeries undertaken in the glaucoma unit of a tertiary center in Spain between 2010 and 2022. Data collected included surgical dates, procedure performed, whether it was standalone or combined, as well as patient demographics including age, sex, and type of underlying glaucoma. Surgeries on individuals under 18 years of age were excluded. An annual comparative analysis was performed to ascertain the evolving trends in glaucoma surgical interventions.ResultsA total of 12,944 surgeries were included in the analysis, comprising 9428 isolated cataract surgeries and 2975 glaucoma procedures. Trabeculectomy, glaucoma drainage devices (GDD), and cyclodestruction, collectively referred to as traditional surgery, demonstrated a decline from 93.2% to 23.6% over the study duration. Minimally invasive glaucoma surgery (MIGS) and minimally invasive bleb surgery (MIBS) demonstrated a significant increase from 3.8% in 2010 to 74.7% in 2022, relative to the total glaucoma surgeries. Furthermore, combined surgeries manifested a noteworthy increase from 39.0% in 2010 to 44.2% in 2022, with 86.4% of combined procedures in 2022 being MIGS or MIBS.ConclusionIn recent years, there has been a noticeable change in the trend of glaucoma surgeries, with MIGS and MIBS procedures experiencing a significant increase and becoming the most commonly performed glaucoma procedures. Consequently, traditional glaucoma surgeries have decreased in frequency.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"938-946"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delayed high-altitude retinal hemorrhages in well-acclimatized lowlanders: A hidden risk unveiled. 高海拔地区视网膜出血的延迟发生在适应性良好的低地居民身上：揭开隐藏风险的面纱。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-10-21 DOI: 10.1177/11206721241292382

Vipin Rana, Anju Pannu, Arnab Sadhukhan, Sandepan Bandopadhayay, Pradeep Kumar, Jaya Kaushik, Meenu Dangi, Atul Gupta

{"title":"Delayed high-altitude retinal hemorrhages in well-acclimatized lowlanders: A hidden risk unveiled.","authors":"Vipin Rana, Anju Pannu, Arnab Sadhukhan, Sandepan Bandopadhayay, Pradeep Kumar, Jaya Kaushik, Meenu Dangi, Atul Gupta","doi":"10.1177/11206721241292382","DOIUrl":"10.1177/11206721241292382","url":null,"abstract":"Background/ObjectivesHigh-altitude retinal hemorrhage (HARH), a frequent entity of high-altitude retinopathy (HAR), is associated with acute exposure to high altitudes (HAs) with rapid ascent. However, the delayed occurrence of HARH in well-acclimatized individuals has received less attention. This study explored the prevalence and characteristics of HARH in individuals who were acclimatized to HA for extended periods, aiming to elucidate the physiological responses of the retina to chronic hypoxic conditions.Subjects/MethodsWe conducted an observational cross-sectional study involving 1,457 male participants who had resided at altitudes above 3353 meters (11,000 ft) in the Himalayan region for more than three months. Patients who had ocular or systemic diseases affecting the retina, chronic retinotoxic medication use or smoking were excluded. Participants underwent comprehensive ophthalmic examination, including the best corrected visual acuity test, dilated fundus examination and photography.ResultsA total of 1,457 males were screened, and the mean age was 34 ± 2 years. Of all the participants screened, 12 (0.82%) had HAR, with all cases occurring at altitudes above 4267 meters (14,000 ft). Seventy-five percent (75%) of the HAR patients had retinal hemorrhage and venous dilatation. Macular involvement and cotton wool spots were observed in 34% and 25% of HAR patients, respectively. Only four participants had foveal involvement with significant visual impairment.ConclusionDelayed HARH in acclimatized individuals underscores the importance of long-term ocular monitoring for those exposed to HA, despite acclimatization, to prevent and manage potential visual impairments.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1061-1066"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of postoperative outcomes after cataract surgery in patients with Juvenile Idiopathic Arthritis-Associated Uveitis. 评估青少年特发性关节炎相关葡萄膜炎患者白内障手术后的效果。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-10-15 DOI: 10.1177/11206721241290272

Gentian Bajraktari, Tomislav Jukić, Miro Kalauz, Martin Oroz, Andrea Radolović Bertetić, Nenad Vukojević

{"title":"Evaluation of postoperative outcomes after cataract surgery in patients with Juvenile Idiopathic Arthritis-Associated Uveitis.","authors":"Gentian Bajraktari, Tomislav Jukić, Miro Kalauz, Martin Oroz, Andrea Radolović Bertetić, Nenad Vukojević","doi":"10.1177/11206721241290272","DOIUrl":"10.1177/11206721241290272","url":null,"abstract":"PurposeTo evaluate the postoperative outcomes of cataract surgery and intraocular lens (IOL) implantation on visual outcomes and complications in pediatric patients with Juvenile Idiopathic Arthritis-Associated Uveitis.MethodsThis study included 25 patients (30 eyes) with uveitis and cataracts who underwent cataract surgery. The study was conducted as a retrospective study. Patients were divided into two groups based on their preoperative treatment: those who received immunomodulatory therapy (IMT) along with systemic corticosteroids and those who received IMT in combination with a biologic therapy. Best corrected visual acuity (BCVA), intraocular pressure (IOP), central macular thickness (CMT), macular volume (MV), and postoperative complications were assessed at various time points up to 12 months. All surgeries were performed by a single surgeon.ResultsSignificant improvement in BCVA were observed postoperatively in both study groups, with approximately 80% of eyes showing improvement. Mean BCVA improved from 0.89 ± 0.63 to 0.37 ± 0.33 in group 1and from 0.82 ± 0.68 to 0.35 ± 0.31 in group 2 after 12 months. Postoperatively, there was a decrease in mean IOP, with no significant variance observed between the two groups. Complications were observed in 73% of cases, including posterior capsular opacification (PCO), secondary glaucoma, and macular edema (ME), but did not significantly differ between groups.ConclusionCataract surgery in children with uveitis associated with JIA presents significant challenges due to the risk of postoperative complications, even with adequate preoperative and postoperative care. The similar improvement in BCVA observed in both groups suggests that different systemic therapies were sufficient for satisfactory control of inflammation before and after surgery.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1109-1116"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Second eye cancellations and trainee involvement with immediate sequential bilateral cataract surgery. 第二眼取消和学员参与立即顺序双侧白内障手术。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-12-05 DOI: 10.1177/11206721241297030

Chun Fung Jeffrey Lam, Khayam Naderi, Maninder Bhogal, David O'Brart, Sancy Low

引用次数: 0

Normal tension glaucoma as initial manifestation of Takayasu arteritis- an unknown entity. 正常紧张性青光眼作为高须动脉炎的初始表现-一种未知的实体。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-01-12 DOI: 10.1177/11206721241310622

Ashok Kumar, Prabhjot Singh, Vijay Kumar Sharma, Vikas Ambiya, Srishti Khullar, Preeti Rk

引用次数: 0

Longitudinal structural changes in central serous chorioretinopathy: A multimodal imaging-based study. 中心性浆液性脉络膜视网膜病变的纵向结构变化：基于多模态成像的研究

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-10-03 DOI: 10.1177/11206721241287253

Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Dmitri Maltsev, Riccardo Sacconi, Ramesh Venkatesh, Nikitha Gurram Reddy, Shivam Madan, Beatrice Tombolini, Luiz H Lima, Varsha Pramil, Giridhar Anantharaman, Antonio Marcelo Casella, Gerardo Ledesma-Gil, Nadia Waheed, Enrico Borrelli, Giuseppe Querques, Jay Chhablani

{"title":"Longitudinal structural changes in central serous chorioretinopathy: A multimodal imaging-based study.","authors":"Niroj Kumar Sahoo, Joshua Ong, Amrish Selvam, Dmitri Maltsev, Riccardo Sacconi, Ramesh Venkatesh, Nikitha Gurram Reddy, Shivam Madan, Beatrice Tombolini, Luiz H Lima, Varsha Pramil, Giridhar Anantharaman, Antonio Marcelo Casella, Gerardo Ledesma-Gil, Nadia Waheed, Enrico Borrelli, Giuseppe Querques, Jay Chhablani","doi":"10.1177/11206721241287253","DOIUrl":"10.1177/11206721241287253","url":null,"abstract":"PurposeTo analyse the longitudinal changes in imaging parameters in eyes with acute or chronic central serous chorioretinopathy (CSCR).MethodsThis was a multicentric, retrospective, longitudinal, observational study in patients with a diagnosis of CSCR and having at least 4 years of follow-up. Trend in choroidal thickness (CT), area of double layer sign (DLS), area of retinal pigment epithelium (RPE) alterations, and area of hyper-autofluorescence were analysed.ResultsA total of 175 eyes of 146 patients with a mean age of 52.9 ± 12.5 years were included. Fifty-two eyes had acute and 123 had chronic CSCR at baseline. There was an overall decreasing trend of CT values during follow up (from 354.4 ± 74.8 at baseline to 343.2 ± 109.4 at final visit). There was a steady rise in DLS width and RPE alteration in the overall cohort (from 811.7 ± 760.6 microns and 3.5 ± 3.3 disc areas respectively at baseline to 1209.1 ± 1113.18 microns, 4.1 ± 3.6 disc areas at final visit). An initial rise in hyper-autofluorescent area followed by steady fall was seen in chronic CSCR. A significant positive correlation (r = 0.54, p = 0.004) was seen between change in DLS width and change in area of hyper-autofluorescence. On linear regression analysis, lower CMT and absence of intraretinal fluid at baseline were associated with greater increase in RPE abnormalities.ConclusionAcute and chronic CSCR had different pattern of change in imaging parameters with area of RPE alterations in acute CSCR not reaching values close to that of chronic CSCR eyes even after long follow up.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1020-1028"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142364859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pigment dispersion syndrome case with concave iris and ocular hypertension managed through a phakic ICL implantation. 一例色素消散综合征病例，伴有凹虹膜和眼压过高，通过植入人工晶体进行治疗。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-18 DOI: 10.1177/11206721241296906

Ignacio Rodriguez-Una, Luis Fernández-Vega-Cueto, Belén Alfonso-Bartolozzi, Andrés Fernández-Vega-Cueto, Irene Martínez-Alberquilla, David Madrid-Costa, Jose F Alfonso

{"title":"A pigment dispersion syndrome case with concave iris and ocular hypertension managed through a phakic ICL implantation.","authors":"Ignacio Rodriguez-Una, Luis Fernández-Vega-Cueto, Belén Alfonso-Bartolozzi, Andrés Fernández-Vega-Cueto, Irene Martínez-Alberquilla, David Madrid-Costa, Jose F Alfonso","doi":"10.1177/11206721241296906","DOIUrl":"10.1177/11206721241296906","url":null,"abstract":"IntroductionA concave iris configuration is a characteristic feature of pigment dispersion syndrome (PDS). Therapeutic strategies to modify this configuration may be considered as first-line options for the treatment of ocular hypertension in PDS patients.Case descriptionA 37-year-old male patient with myopic anisometropia presented bilateral PDS with concave iris, Krukenberg's spindle and iris transillumination defect in both eyes. The intraocular pressure (IOP) was 27 mmHg in both eyes. Optic nerve and visual field parameters were normal. The right eye was treated with a neodymium:YAG LPI. In the left eye, an implantable collamer lens (ICL) V4c model implantation for myopia correction was performed. Six-months postoperatively, both eyes evidenced an anteriorization of the iris, the morphology of the concave iris improved with the ICL V4c in place, becaming flattener in left eye. The IOP was 18 mmHg without treatment.ConclusionThis case report reinforces the idea that in myopic patients with a concave iris, the refractive correction approach through ICL V4c implantation might also improve the iris configuration, similarly to laser peripheral iridotomy (LPI). Therefore, in this specific patient profile, this surgical procedure might be considered as a prophylactic treatment alternative to prevent the complications associated with this iris configuration, although its invasive nature should be taken into consideration.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP25-NP29"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of the Natural Course of Quiescent Macular Neovascularization with Optical Coherence Tomography Angiography. 利用光学相干断层扫描血管造影术分析静止黄斑新生血管的自然病程。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-18 DOI: 10.1177/11206721241298025

Yeliz Delibay Akgun, Emin Kurt, Muhammed Altinisik

{"title":"Analysis of the Natural Course of Quiescent Macular Neovascularization with Optical Coherence Tomography Angiography.","authors":"Yeliz Delibay Akgun, Emin Kurt, Muhammed Altinisik","doi":"10.1177/11206721241298025","DOIUrl":"10.1177/11206721241298025","url":null,"abstract":"PurposeThis study investigates the natural progression of quiescent macular neovascularization (qMNV) using optical coherence tomography angiography (OCTA).MethodsThe study monitored 30 eyes of 28 qMNV patients over a period of at least six months. Best-corrected visual acuity (BCVA), optical coherence tomography (OCT), and OCTA were used to perform qualitative and quantitative analyses, noting any cases of activation during follow-up.ResultsAmong the 30 eyes (14 female, mean age 69.70 ± 7.63 years), 21 had age-related macular degeneration (AMD) and 9 had pachychoroid neovasculopathy (PNV). The mean follow-up duration was 18.9 months. There were no significant changes in qualitative morphological features, BCVA, or choroidal thickness (p > 0.05). However, there was a statistically significant increase in the areas of MNV and flow (p = 0.043 and p = 0.018, respectively). BCVA and MNV area showed no significant correlation (p = 0.103). Four cases (13.33%) showed activation after an average follow-up period of 27.75 months (6 to 48). Additionally, extrafoveal location was identified as a significant risk factor for exudation (p = 0.033).ConclusionOCTA is a valuable tool for monitoring qMNV and identifying potential predictors of disease activation. The qMNV area may increase over time, even in the absence of activation. Extrafoveal location appears to be a potential risk factor for qMNV activation.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1075-1081"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

To explore the protective effect and mechanism of KLF7 overexpression on retinal ganglion cells after optic nerve crush in mice. 探索 KLF7 过表达对小鼠视神经挤压后视网膜神经节细胞的保护作用及其机制。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-08 DOI: 10.1177/11206721241297023

Dihao Hua, Jingsai Gu, Feijia Xie, Yishuang Xu, Zongyuan Li, Hongmei Zheng, Zhen Chen

{"title":"To explore the protective effect and mechanism of KLF7 overexpression on retinal ganglion cells after optic nerve crush in mice.","authors":"Dihao Hua, Jingsai Gu, Feijia Xie, Yishuang Xu, Zongyuan Li, Hongmei Zheng, Zhen Chen","doi":"10.1177/11206721241297023","DOIUrl":"10.1177/11206721241297023","url":null,"abstract":"PurposeTo investigate the protective effect and mechanism of Krüppel-like factor 7 (KLF7) on retinal ganglion cells (RGCs) after optic nerve crush (ONC).MethodsNinety 10-week-old C57BL/6J mice were randomly assigned to five groups. The blank control group (group A), IVT (intravitreal injection) of KLF7 (group B), IVT of phosphate-buffered saline after ONC (group C), IVT of KLF7 after ONC (group D), and IVT of green fluorescent protein after ONC (group E). Retinal electroretinography and immunofluorescence staining were performed to observe the function and survival rate of RGCs on days 3 and 7 after ONC. The Western Blot determined the expressions of JNK 1, ERK, P38, NF-κB, IL-1, IL-6, and TNF-α seven days after ONC.ResultsAfter ONC, KLF7 gradually increased from day 3 to day 14, with the peak noted a peak on day 7. On day 7 after ONC, the RGC survival rate in Group D was significantly higher than in groups C (P = 0.028) and E (P = 0.007). The negative PhNR wave amplitude significantly decreased in groups C (P = 0.03) and E (P = 0.04) compared to group D. Moreover, group D also showed significantly higher ERK levels among the groups (all P < 0.01); NF-κB, IL-1, IL-6, and TNF-α expression decreased significantly in group D compared with groups C and E (all P < 0.01).ConclusionsOverexpression of KLF7 improved the survival rate and function of RGCs in mice ONC models by activating the ERK pathway and inhibiting relevant inflammatory factors. KLF7 may be a promising protective factor against optic nerve damage.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1130-1140"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0