European Journal of Ophthalmology最新文献_第8页

Artificial intelligence in diabetic retinopathy screening: Mind the workflow. 人工智能在糖尿病视网膜病变筛查中的应用：注意工作流程。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-11-05 DOI: 10.1177/11206721241297185

Roberto Perilli

引用次数: 0

Bagel sign and how to avoid it in DMEK surgery. 面包圈征兆以及如何避免在 DMEK 手术中出现这种征兆。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-11-15 DOI: 10.1177/11206721241299473

Luca Pagano, Fadi Alfaqawi, Alfredo Borgia, Francesco Aiello, Matteo Airaldi, Stephen B Kaye, Vito Romano

{"title":"Bagel sign and how to avoid it in DMEK surgery.","authors":"Luca Pagano, Fadi Alfaqawi, Alfredo Borgia, Francesco Aiello, Matteo Airaldi, Stephen B Kaye, Vito Romano","doi":"10.1177/11206721241299473","DOIUrl":"10.1177/11206721241299473","url":null,"abstract":"Purpose: To provide a detailed description of the recommended surgical technique for gas injection during Descemet's Membrane Endothelial Keratoplasty (DMEK) surgery and highlight intraoperative sign that emerged in case of fluid retention in the interface.Methods: Gas injection recommended surgical technique is 2 steps procedure using a 1 ml syringe: the first step consists in injecting centrally to the graft and very slowly a bubble of gas smaller than the DMEK graft size, the second step, after checking the absence of fluid interface (no bagel sign), consists in enlarging the gas bubble to the desired filling.Results: Bagel sign allows surgeons to look for interface fluid and correct for potential issues leading to graft detachment. The recommended surgical technique for gas injection also may help to prevent fluid retention in the interface and reduce the risk of graft detachment.Conclusion: Detecting a fluid interface retention at the end of DMEK surgery through iOCT or simply looking for the bagel sign may help to prevent post-operative complications.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"741-746"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bubble-graft coverage after Descemet Membrane Endothelial Keratoplasty depending on gaze angle. 视注视角度而定的 Descemet 膜内皮角膜移植术后气泡移植覆盖率。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-09 DOI: 10.1177/11206721241267277

Maximilian Friedrich, Hyeck-Soo Son, Rebecca Charlotte Buhl, Christine Maria Meyer, Timur Mert Yildirim, Ramin Khoramnia, Gerd Uwe Auffarth, Victor Aristide Augustin

{"title":"Bubble-graft coverage after Descemet Membrane Endothelial Keratoplasty depending on gaze angle.","authors":"Maximilian Friedrich, Hyeck-Soo Son, Rebecca Charlotte Buhl, Christine Maria Meyer, Timur Mert Yildirim, Ramin Khoramnia, Gerd Uwe Auffarth, Victor Aristide Augustin","doi":"10.1177/11206721241267277","DOIUrl":"10.1177/11206721241267277","url":null,"abstract":"Purpose: In Descemet Membrane Endothelial Keratoplasty (DMEK) a gas bubble is usually used to attach the graft to the host cornea. In this study, we observed the bubble size and bubble-graft coverage at different gaze angles following DMEK.Methods: This observational prospective study analyzed 465 images of patients who underwent an uneventful DMEK. Intraoperatively, the anterior chamber was filled up to 90% of its volume with a 20% Sulfur Hexafluoride (SF6) gas-air mixture. Postoperatively, the bubble was photographed daily in different gaze angles ranging from a supine position (0°) to an upright position (90°) and a slightly inclined position (105°). The primary outcomes were bubble-graft coverage and bubble diameters depending on the gaze angle and time after DMEK.Results: The highest bubble-graft coverage was achieved at a 0° gaze angle at all times of measurement. In the first 48 h after DMEK, the mean bubble-graft coverage was over 85% at a gaze angle between 0° and 45°. Starting 72 h after DMEK, the graft coverage declined at all gaze angles. The graft coverage at a 0° gaze angle was 88.61 ± 10.90% after 96 postoperative hours, while the graft coverage was below 85% at all other gaze angles.Conclusion: Our clinical results provide novel insight into variation in bubble-graft coverage as a function of gaze angle and may be used to aid in patient counselling for appropriate body positioning following DMEK to prevent early graft detachment. Maintaining supine positioning seems to be most advantageous starting 48 h after DMEK.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"504-510"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A stepwise implementation of the Slovenian National Diabetic Retinopathy Screening Program - evaluation of the first 4.5 years. 逐步实施斯洛文尼亚国家糖尿病视网膜病变筛查计划--对前 4.5 年的评估。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-02 DOI: 10.1177/11206721241267029

Marko Šulak, Kristina Jevnikar, Fran Drnovšek, Levin Vrhovec, Mojca Urbančič, Maja Potrč, Angela Thaler, Neža Čokl, Jelka Zaletel, Mojca Globočnik Petrovič

{"title":"A stepwise implementation of the Slovenian National Diabetic Retinopathy Screening Program - evaluation of the first 4.5 years.","authors":"Marko Šulak, Kristina Jevnikar, Fran Drnovšek, Levin Vrhovec, Mojca Urbančič, Maja Potrč, Angela Thaler, Neža Čokl, Jelka Zaletel, Mojca Globočnik Petrovič","doi":"10.1177/11206721241267029","DOIUrl":"10.1177/11206721241267029","url":null,"abstract":"Background: This retrospective cohort study aimed to assess the characteristics of patients enrolled in the national diabetic retinopathy (DR) screening program and evaluate the selected program's quality elements in the first five years after implementation.Methods: Patients who underwent DR screening between February 2018 and June 2022 at the University Medical Centre Ljubljana were included. General patient characteristics (age, sex, type and therapy of diabetes mellitus (DM), duration of DM, blood HbA1c levels), best corrected visual acuity, stage of DR, presence of sight-threatening diabetic retinopathy (STDR), and selected quality indicators (quality of photographs, re-screening interval, time to treatment) were recorded and evaluated.Results: A total of 34 654 screening examinations were performed on 13 513 patients with diabetes. The majority (77.3%) had Type 2 diabetes, with a mean DM duration of 9.74 ± 9.87 years. In 55.9% of patients, DM duration was less than ten years, and the mean HbA1c was 7.33% ± 1.49. DR signs were noted in 29.1% of patients and 0.89% of patients exhibited STDR. After establishing the diagnosis of STDR, treatment was initiated in 3.43 ± 1.98 months.Conclusion: Implementing the DR screening program provides valuable insights into managing diabetic retinopathy nationwide. It allows for the early detection of sight-threatening DR and facilitates timely and effective treatment, which could help prevent severe visual impairment.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"660-668"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and significance of fovea plana in patients with epiretinal membrane. 视网膜外膜患者平面眼窝的患病率和意义。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-07-26 DOI: 10.1177/11206721241265994

R Lejoyeux, J Liberto, S Bonnin, Y Le Mer, S Bruneau, R Tadayoni

{"title":"Prevalence and significance of fovea plana in patients with epiretinal membrane.","authors":"R Lejoyeux, J Liberto, S Bonnin, Y Le Mer, S Bruneau, R Tadayoni","doi":"10.1177/11206721241265994","DOIUrl":"10.1177/11206721241265994","url":null,"abstract":"Introduction: Fovea plana is indicative of an immature inner retina, yet its association with epimacular membrane (ERM) remains unexplored. This study aims to investigate the prevalence of fovea plana in the contralateral eye of patients diagnosed with ERM.Methods: A retrospective analysis was conducted on consecutive patients in a monocentric tertiary ophthalmic department between January and April 2021. The study included all patients referred for ERM, with dense optical coherence tomography (OCT) B-scans utilized to assess the incidence of fovea plana in the contralateral eye. Patients with bilateral ERM were excluded from the analysis.Results: Out of 181 patients, 26 exhibited fovea plana in the contralateral eye, resulting in an incidence rate of 14.3%. Demographic characteristics, OCT patterns, and indications for surgery did not differ significantly between patients with and without fovea plana.Discussion: The prevalence of fovea plana in patients with ERM did not exhibit a statistically significant increase compared to the reported incidence in patients undergoing preoperative cataract surgery.Conclusion: In our cohort, the incidence of fovea plana in patients with ERM was determined to be 14.3%.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"645-649"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparability analysis of the HNT-1P Huvitz non contact tonometer for the measurement of intraocular pressure. 用于测量眼压的 HNT-1P Huvitz 非接触式眼压计的可比性分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-07-26 DOI: 10.1177/11206721241263624

Alicia Cárceles Montoya, Carlos Enrique Monera Lucas, Claudia Patricia Tarazona Jaimes, Daniel Romero Valero, Alejandro Moya Martínez, José Juan Martínez Toldos

{"title":"Comparability analysis of the HNT-1P Huvitz non contact tonometer for the measurement of intraocular pressure.","authors":"Alicia Cárceles Montoya, Carlos Enrique Monera Lucas, Claudia Patricia Tarazona Jaimes, Daniel Romero Valero, Alejandro Moya Martínez, José Juan Martínez Toldos","doi":"10.1177/11206721241263624","DOIUrl":"10.1177/11206721241263624","url":null,"abstract":"Purpose: To evaluate the diagnostic validity of the HNT-1P non-contact tonometer (Huvitz) as a tool for accurately measuring intraocular pressure (IOP) in patients with healthy eyes, compared to the Goldmann applanation tonometer (GAT), which is the Gold Standard method for measurement of IOP.Methods: Observational, descriptive, transversal study using 148 eyes of 74 healthy patients without a diagnosis of glaucoma or other ophthalmological diseases. Three measurements of IOP were taken in each eye, using three tonometers: HNT-1P, ICR100, and GAT. The median IOP (quartiles) and mean IOP (SD) its statistical significance were calculated, and comparisons were made between the mean and median IOP values found in three groups: GAT-HNT, GAT-ICR, and HNT-ICR. The difference in mean and median IOP was analyzed in each of the three study groups, and its statistical significance and concordance correlation coefficient (CCC) were calculated.Results: The median IOP with HNT-1P was statistically significantly lower than the median IOP with GAT, (1.1 mmHg, p < 0.001). The median IOP with HNT-1P was also lower than the median IOP with ICR100. As an additional result, the median IOP with GAT was lower than the median IOP with ICR. The CCC was moderate for HNT-ICR (0.72) and low for GAT-HNT and GAT-ICR (0.43 and 0.38, respectively).Conclusions: HNT-1P (Huvitz) provides statistically significantly lower IOP values than those obtained with GAT. HNT-1P could be used for screening of ocular hypertension in postoperative patients. The IOP measurement obtained with HNT-1P should be confirmed with GAT. HNT-1P yields lower IOP values than those obtained with ICR.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"544-550"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Avacopan in the treatment of refractory scleritis secondary to granulomatosis with polyangiitis: A case report. 阿伐潘治疗继发于肉芽肿伴多血管炎的难治性巩膜炎：病例报告。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-10-30 DOI: 10.1177/11206721241295298

Emilia Bober, Bhavana Sharma, Ioannis Papasavvas, Stephen McAdoo, Harry Petrushkin

{"title":"Avacopan in the treatment of refractory scleritis secondary to granulomatosis with polyangiitis: A case report.","authors":"Emilia Bober, Bhavana Sharma, Ioannis Papasavvas, Stephen McAdoo, Harry Petrushkin","doi":"10.1177/11206721241295298","DOIUrl":"10.1177/11206721241295298","url":null,"abstract":"Purpose: Avacopan is a novel C5a receptor inhibitor which was recently licensed for treatment of severe granulomatosis with polyangiitis (GPA) in the European Union and the United Kingdom. To the best of our knowledge, this is the first described case on initial ophthalmic outcomes in a patient with severe GPA and concurrent refractory scleritis treated with avacopan.Case description: We present a case of de novo scleritis in a 77-year-old male with a background of retinitis pigmentosa with Argus II implant in situ. Severe scleral inflammation occurred following a suture removal from the implant site. Remission was not maintained despite orbital floor injections and high dose oral prednisolone. The diagnostic work-up revealed GPA which quickly progressed to involve vital organs. In view of his systemic deterioration, he was started on avacopan alongside rituximab, cyclophosphamide and high dose oral prednisolone. Sustained remission of scleritis was noted after 7 months of treatment with avacopan and low dose oral prednisolone with no other maintenance immunosuppression.Conclusion: We observed a sustained benefit of avacopan in allowing for successful taper of systemic steroids. We report that avacopan used alongside other immunosuppressants may be a viable option in patients with GPA and concurrent refractory scleritis. Further studies are needed to establish the longer term impact of this agent on the control of scleral inflammation.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP17-NP21"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optic disc pit maculopathy: Covering or filling technique with human amniotic membrane patch to treat the optic disc pit maculopathy? 视盘凹陷性黄斑病变：用人羊膜贴片覆盖还是填充技术治疗视盘凹陷性黄斑病变？

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-11-03 DOI: 10.1177/11206721241296026

Tito Fiore, Davide Tucci, Nicola De Santi, Marco Lupidi, Carlo Cagini, Cesare Mariotti

{"title":"Optic disc pit maculopathy: Covering or filling technique with human amniotic membrane patch to treat the optic disc pit maculopathy?","authors":"Tito Fiore, Davide Tucci, Nicola De Santi, Marco Lupidi, Carlo Cagini, Cesare Mariotti","doi":"10.1177/11206721241296026","DOIUrl":"10.1177/11206721241296026","url":null,"abstract":"Purpose: To describe two patients affected by optic disk pit-maculopathy ODP-M surgically treated with pars-plana vitrectomy (PPV) and the apposition of a human Amniotic Membrane (hAM) patch.Methods: Patients underwent a PPV with the apposition of a hAM patch to cover the ODP. In case 1, a 2nd surgery was necessary to push the hAM patch inside the pit, whereas in case 2 the patch was pulled inside the pit following the pressure gradient when infusion was turned on.Results: After surgery the hAM patch filled the ODP and in both cases, during follow-up, there was a progressive reduction of macular OCT changes and a concomitant BCVA improvement.Conclusion: Our experience seems to support the idea that the dynamic fluctuation of pressure between intra-ocular and intra-cranial spaces can direct the movement of fluid through the anomalous communication created by the ODP. In this perspective, our cases seem to support the idea that the primary goal of any surgery should be to create a permanent barrier to fluid migration through the ODP to the intra-ocular space, and that hAM can be successfully used to fill the OPD and to create that permanent barrier to achieve the resolution of ODP-M.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"760-764"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the impact of caloric restriction, body mass index and exercise on primary open-angle glaucoma: A review. 评估热量限制、体重指数和运动对原发性开角型青光眼的影响：综述。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-22 DOI: 10.1177/11206721241274445

Jonathan Ym Lai, Patrick Mclarnon, Carl Sheridan, Neeru A Vallabh

{"title":"Evaluating the impact of caloric restriction, body mass index and exercise on primary open-angle glaucoma: A review.","authors":"Jonathan Ym Lai, Patrick Mclarnon, Carl Sheridan, Neeru A Vallabh","doi":"10.1177/11206721241274445","DOIUrl":"10.1177/11206721241274445","url":null,"abstract":"This literature review evaluates any possible links between primary open-angle glaucoma (POAG) and caloric restriction (CR), body mass index (BMI), and exercise, aiming to map the extent of the literature. Its primary objective is to recognise the nature and breadth of research evidence, identify possible gaps in these topics and develop future studies. The databases searched were MEDLINE (PudMed), Scopus and ScienceDirect, in April 2023 for articles published in English, with no date restriction. A total of 447 search results were retrieved. Of these, 73 were related to CR, 249 to BMI, and 125 to exercise. Records identified included systematic reviews, meta-analyses, randomised controlled trials, cohort studies and animal studies. CR has been shown to halt the degeneration of retinal ganglion cells and protect against various glaucomatous processes in animal models. Low BMI has been shown to be associated with an increased risk of POAG and a faster rate of visual field deterioration in POAG. However, the association between high BMI and POAG is not consistent. Exercise has been shown to cause mechanical, vascular, and neurobiological changes affecting the pathophysiology of POAG. The present review helps identify key characteristics and factors relating to the impacts of CR, BMI, or exercise on POAG.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"429-440"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mendelian randomization supports causal effects of inflammatory biomarkers on myopic refractive errors. 孟德尔随机分析支持炎症生物标志物对近视屈光不正的因果效应。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-02 DOI: 10.1177/11206721241266871

Yu-Ting Kang, Zhen-Huang Zhuang, Xi He, Ying Huang, Ning-Li Wang, Tao Huang, Shi-Ming Li

{"title":"Mendelian randomization supports causal effects of inflammatory biomarkers on myopic refractive errors.","authors":"Yu-Ting Kang, Zhen-Huang Zhuang, Xi He, Ying Huang, Ning-Li Wang, Tao Huang, Shi-Ming Li","doi":"10.1177/11206721241266871","DOIUrl":"10.1177/11206721241266871","url":null,"abstract":"Aims: To determine whether inflammatory biomarkers are causal risk factors for more myopic refractive errors.Methods: Northern Sweden Population Health Study (NSPHS), providing inflammatory biomarkers data; UK Biobank, providing refractive errors data. 95,619 European men and women aged 40 to 69 years with available information of refractive errors and inflammatory biomakers. Inflammatory biomarkers including ADA, CCL23, CCL25, CD6, CD40, CDCP-1, CST5, CXCL-5, CXCL-6, CXCL-10, IL-10RB, IL-12B, IL-15RA, IL-18R1, MCP-2, MMP-1, TGF-β1, TNF-β, TWEAK and VEGF-A were exposures, and spherical equivalent (SE) using the formula SE = sphere + (cylinder/2) was outcome.Results: Mendelian randomization analyses showed that each unit increase in VEGF-A, CD6, MCP-2 were causally related to a more myopic refractive errors of 0.040 D/pg.mL-1 (95% confidence interval 0.019 to 0.062; P = 2.031 × 10-4), 0.042 D/pg.mL-1 (0.027 to 0.057; P = 7.361 × 10-8) and 0.016 D/pg.mL-1 (0.004 to 0.028; P = 0.009), and each unit increase in TWEAK was causally related to a less myopic refractive errors of 0.104 D/pg.mL-1 (-0.152 to -0.055; P = 2.878 × 10-5). Tested by the MR-Egger, weighted median, MR-PRESSO, Leave-one-out methods, our results were robust to horizontal pleiotropy and heterogeneity in VEGF-A, MCP-2, CD6, but not in TWEAK.Conclusions: Our Mendelian Randomization analysis supported the causal effects of VEGF-A, MCP-2, CD6 and TWEAK on myopic refractive errors. These findings are important for providing new indicators for early intervention of myopia to make myopic eyesight threatening consequences less inevitable.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"400-408"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0