European Journal of Ophthalmology最新文献_第8页

Effectiveness of dynamic phototherapy in the management of telangiectatic capillaries: A case series. 动态光疗在管理毛细血管扩张的有效性：一个病例系列。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-18 DOI: 10.1177/11206721251351490

Amandine Moulin, Lucas Sejournet, Thibaud Mathis, Laurent Kodjikian

{"title":"Effectiveness of dynamic phototherapy in the management of telangiectatic capillaries: A case series.","authors":"Amandine Moulin, Lucas Sejournet, Thibaud Mathis, Laurent Kodjikian","doi":"10.1177/11206721251351490","DOIUrl":"https://doi.org/10.1177/11206721251351490","url":null,"abstract":"PurposeTelangiectatic capillaries (TelCaps) are large capillary microaneurysms that can be found in diabetic patients. Focal laser photocoagulation is the standard treatment for these lesions. In case of a lesion too close to the fovea, there is a risk of central scotoma and conventional laser should not be used. In this case, dynamic phototherapy (PDT) can be discussed.Case reportTwo patients with perifoveal TelCaps associated with diabetic macular edema were treated with PDT. There was persistent central macular edema in spite of a well-executed treatment with intravitreal injections (IVT). Both visual acuity and central macular thickness improved after PDT. This therapy seems to be a possible option in the absence of another therapeutic solution for the treatment of perifoveal TelCaps with promising results should be noted despite the difficulty accessibility to Verteporfin.ConclusionThe management of perifoveal TelCaps is complex due to their impact on visual acuity, the therapeutic burden for patients, as well as the potential complications associated with focal laser. In the absence of other therapeutic options, the use of PDT may prove relevant in this indication.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351490"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Changes in various ocular parameters of patients undergoing hemodialysis. 血液透析患者各项眼参数的变化。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-18 DOI: 10.1177/11206721251349681

Aseem Kumar, Vijaya Sahu, Somen Misra, Vinay Rathore, Bharat Gurnani, Kirandeep Kaur

{"title":"Changes in various ocular parameters of patients undergoing hemodialysis.","authors":"Aseem Kumar, Vijaya Sahu, Somen Misra, Vinay Rathore, Bharat Gurnani, Kirandeep Kaur","doi":"10.1177/11206721251349681","DOIUrl":"https://doi.org/10.1177/11206721251349681","url":null,"abstract":"PurposeTo assess the alterations in various ocular parameters in patients undergoing hemodialysis.DesignProspective, observational study.MethodsThe study included 113 eyes from 113 patients who underwent hemodialysis due to chronic kidney disease and acute kidney injury between January 2021 and August 2022. All participants underwent complete ophthalmic exam which included best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP) measurement and dilated examination using slit lamp biomicroscope and indirect ophthalmoscope. Optical coherence tomography (OCT) was done for all patients before they underwent hemodialysis and central subfield thickness (CST), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness were assessed. The ophthalmic exam and OCT scan were repeated within 1-2 h of hemodialysis.ResultsThe mean age (+/- SD) of the study population was 42.14 ± 13.25 years, with 65.5% males. Most participants were aged 41-60 years. BCVA and IOP did not change significantly after hemodialysis (p = 0.74 and p = 0.37, respectively). Retinal parameters showed significant changes, with decreased CST (p < 0.001) and GCC thickness (p = 0.04). There was no significant change in RNFL thickness (p = 0.44). CST positively correlated with dialysate flow rate and negatively with blood flow rate. A weak correlation was found between GCC thickness and ultrafiltration and dialysate flow rate.ConclusionHemodialysis causes alterations in retinal parameters with a decrease in the CST and GCC thickness.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251349681"},"PeriodicalIF":1.4,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rock-Inhibitors eyedrops preventing cataract surgery induced corneal failure in Fuchs corneal dystrophy. 岩石抑制剂滴眼液预防白内障手术引起的角膜衰竭。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-17 DOI: 10.1177/11206721251351154

Daniele Gaudenzi, Chiara De Gregorio, Francesco Cutrupi, Francesco Branda, Marco Coassin, Antonio Di Zazzo

{"title":"Rock-Inhibitors eyedrops preventing cataract surgery induced corneal failure in Fuchs corneal dystrophy.","authors":"Daniele Gaudenzi, Chiara De Gregorio, Francesco Cutrupi, Francesco Branda, Marco Coassin, Antonio Di Zazzo","doi":"10.1177/11206721251351154","DOIUrl":"https://doi.org/10.1177/11206721251351154","url":null,"abstract":"PurposeTo evaluate the safety and efficacy of prophylactic Ripasudil in maintaining corneal endothelial function and preventing corneal failure in patients with late-stage Fuchs corneal dystrophy (FCD) undergoing femtolaser-assisted cataract surgery.Major findingsThis prospective, randomized, open-label, controlled interventional study included 41 eyes from 27 patients, 27 eyes treated with Ripasudil and 14 with hyaluronic acid as a control. Treatment was administered from 1 month before cataract surgery through 2 months postoperatively. Primary outcomes included best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell density and morphology, assessed at baseline, 3 months, and 9 months after surgery. Statistical analysis was performed using the unpaired t-test with Welch's correction and the Wilcoxon matched-pairs test, with a significance threshold of p < 0.05. The Ripasudil group showed a significant improvement in BCVA, from0.3 ± 0.3 to 0.2 ± 0.2 LogMAR (p = 0.01), along with stable CCT (556.3 ± 76.4 μm at baseline vs. 563.3 ± 72.2 μm at post-operative month 3, p = 0.39). In contrast, the control group demonstrated no significant improvement in BCVA (p = 0.13) and a significant increase in CCT (from 591.9 ± 59.3 μm to 658.4 ± 74.6 μm, p < 0.01). Endothelial cell density, polymegathism, and pleomorphism remained stable in both groups. At 9 months, Ripasudil-treated eyes continued to show stability in both BCVA and CCT, with no adverse events reported.ConclusionRipasudil demonstrated a protective effect on the corneal endothelium during cataract surgery in late-stage FCD patients, with better visual outcomes and reduced postoperative corneal edema.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351154"},"PeriodicalIF":1.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial genes in lipid metabolism pathway and susceptibility to primary open and angle closure glaucoma. 线粒体基因与脂质代谢途径及原发性开闭角型青光眼的易感性。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-17 DOI: 10.1177/11206721251349867

Suganya Kandeeban, Rashima Asokan, Shantha Balekudaru, Vijaya Lingam, Ronnie George, Sarangapani Sripriya

{"title":"Mitochondrial genes in lipid metabolism pathway and susceptibility to primary open and angle closure glaucoma.","authors":"Suganya Kandeeban, Rashima Asokan, Shantha Balekudaru, Vijaya Lingam, Ronnie George, Sarangapani Sripriya","doi":"10.1177/11206721251349867","DOIUrl":"https://doi.org/10.1177/11206721251349867","url":null,"abstract":"BackgroundMitochondrial genes regulate lipid metabolism and both are associated with the pathology of glaucoma. Here, we studied the genetic association of mitochondrial genes involved in lipid metabolic pathways with glaucoma and its ocular quantitative traits (QTs).MethodsPolymerase chain reaction based direct sequencing followed by MITOMAP analysis was performed for NADH (MT-ND1, MT-ND2, MT-ND5 and MT-ND6); Adenosine triphosphate (ATP) synthase (MT-ATPase6) and Cytochrome B subunit (MT-CYB) genes in Primary Open angle glaucoma (POAG), closed angle glaucoma (PACG) patients (N = 50 in each group) and unrelated healthy controls (N = 150). The effect of variations on protein stability was analyzed in Dynamut2 and I-Mutant2.0 server. Linear regression analysis was performed for the association of mtDNA variations with QTs.ResultsWe observed 57% of unique segregating sites in patients, that were comparatively higher in MT-ND6 gene. Six common mtSNPs were statistically significant and further associated with VCDR [(m.13469T > A (MT-ND5), m.8860A > G (MT-ATPase6), m.15326A > G (MT-CYB)]. Insilico analysis showed that the disease associated variations in MT-ND5 and MT-ND6 genes decreased protein stability and loss of hydrophobic interaction. Gene expression analysis showed a higher connectivity for MT-ND5 gene with SORT1 and TMBIM6 gene.ConclusionOur results showed a significantly higher mutation rate in MT-ND6, MT-CYB and NT-ND5 genes in patients and also suggested a possible association between the mtSNPs and QTs. Lack of functional studies and insufficient lipid profile data to validate the study results limits the study findings and are to be addressed further in an increased sample size.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251349867"},"PeriodicalIF":1.4,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the Letter to the Editor: On evaluating AI Chatbots in glaucoma patient educationRegarding the article: "The performance of ChatGPT-4 and Bing Chat in frequently asked questions about glaucoma" [Eur J Ophthalmol. 2025 Feb 19; doi: 10.1177/11206721251321197]. 关于《chatggt -4和Bing Chat在青光眼常见问题中的表现》一文[Eur J Ophthalmol. 2025 Feb 19；doi: 10.1177 / 11206721251321197)。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-16 DOI: 10.1177/11206721251350862

İbrahim Edhem Yılmaz, Levent Doğan

引用次数: 0

Weight management in idiopathic intracranial hypertension: A role for precision medicine in obesity therapeutics. 特发性颅内高压的体重管理：精准医学在肥胖治疗中的作用。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-16 DOI: 10.1177/11206721251350822

Maria Susan Varughese, Ananth Ullal Nayak

引用次数: 0

Artificial intelligence versus ophthalmology experts: Comparative analysis of responses to blepharitis patient queries. 人工智能与眼科专家：对睑炎患者查询的反应的比较分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-16 DOI: 10.1177/11206721251350809

Daniel Bahir, Audrey Rostov, Yumna Busool Abu Eta, Shirin Hamed Azzam, David Lockington, Joshua C Teichman, Artemis Matsou, Clara C Chan, Elad Shvartz, Michael Mimouni

{"title":"Artificial intelligence versus ophthalmology experts: Comparative analysis of responses to blepharitis patient queries.","authors":"Daniel Bahir, Audrey Rostov, Yumna Busool Abu Eta, Shirin Hamed Azzam, David Lockington, Joshua C Teichman, Artemis Matsou, Clara C Chan, Elad Shvartz, Michael Mimouni","doi":"10.1177/11206721251350809","DOIUrl":"https://doi.org/10.1177/11206721251350809","url":null,"abstract":"ObjectiveTo assess the accuracy and clinical education value of responses from AI models (GPT-3.5, GPT-4o, Gemini, Gemini Advanced) compared to expert ophthalmologists' answers to common patient questions about blepharitis, and evaluate their potential for patient education and clinical use.MethodsThirteen frequently asked questions about blepharitis were selected. Responses were generated by AI models and compared to expert answers. A panel of ophthalmologists rated each response for correctness and clinical education value using a 7-point Likert scale. The Friedman test with post hoc comparisons was used to identify performance differences.ResultsExpert responses had the highest correctness (6.3) and clinical education value (6.4) scores, especially in complex, context-driven questions. Significant differences were found between expert and AI responses (P < 0.05). Among AI models, GPT-3.5 performed best in simple definitions (correctness: 6.4) but dropped to 5.5 in nuanced cases. GPT-4o followed (5.4), while Gemini and Gemini Advanced scored lower (5.0 and 4.9), especially in diagnostic and treatment contexts.ConclusionsAI models can support patient education by effectively answering basic factual questions about blepharitis. However, their limitations in complex clinical scenarios highlight the continued need for expert input. While promising as educational tools, AI should complement-not replace-clinician guidance in patient care.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251350809"},"PeriodicalIF":1.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unilateral congenital upper eyelid eversion: A rare presentation in a neonate. 单侧先天性上眼睑外翻：罕见的新生儿表现。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-16 DOI: 10.1177/11206721251350821

Sofien Atitallah, Marwa Ben Ayed, Olfa Bouyahia, Sonia Mazigh, Salem Yahyaoui, Samir Boukthir

引用次数: 0

ChatGPT-4 and Bing Chat in frequently asked questions about glaucoma. ChatGPT-4和必应聊天中关于青光眼的常见问题。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-16 DOI: 10.1177/11206721251350858

Amnuay Kleebayoon, Viroj Wiwanitkit

引用次数: 0

Lessons from the vitreoretinal theater using the Beyeonics One™ surgical visualization system. Beyeonics One™手术可视化系统在玻璃体视网膜手术中的应用。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-16 DOI: 10.1177/11206721251349248

Lorenzo Iuliano, Eleonora Corbelli, Francesco Bandello, Marco Codenotti

引用次数: 0