{"title":"Phthiriasis palpebrarum: A systematic review and illustrative case presentation.","authors":"Fuxiang Yuan, Dong Tang, Zhanyu Zhou","doi":"10.1177/11206721251371361","DOIUrl":"https://doi.org/10.1177/11206721251371361","url":null,"abstract":"<p><p>To investigate the clinical features, diagnostic methods, and treatment modalities of Phthiriasis palpebrarum (PP). We conducted a systematic review of case reports and case series of PP by searching MEDLINE, Embase, and ISI Web of Knowledge databases. Demographic and clinical features were extracted and reviewed. Furthermore, a case of <i>Phthirus pubis</i> infestation in the eyelashes of a young boy is also described. A total of 88 records involving 110 cases were included in the final analysis. The median age at admission was 21 years, with an equal proportion of males and females. The common clinical symptoms were itching (81.7%), irritation (26.6%), and redness (17.4%), with 67% of cases exhibiting bilateral involvement. The median duration of symptoms at presentation was 4 weeks. Approximately one-third of patients were misdiagnosed and unsuccessfully treated before presentation. Complications such as conjunctivitis and keratitis occurred in 30 cases (27.5%) and 4 cases (3.7%), respectively. Slit lamp examination or dermoscopy with light microscopy were the main diagnostic modalities. A combination of treatment modalities was employed in 69.7% of the cases. The main nonpharmacological therapies included mechanical removal of lice and nits and trimming of eyelashes. Commonly used pharmacological therapies were topical petrolatum jelly and topical antibiotics/corticosteroids. Over a median follow-up of 2 weeks, symptoms and lice/nits were resolved in most patients. Ophthalmologists should be aware of the possibility of PP in patients presenting with ocular itching.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251371361"},"PeriodicalIF":1.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Talha Soorma, Luciane Dreher Irion, Andrew James Walkden, Amira Stylianides
{"title":"Sarcoid conjunctival granuloma responding to biological therapy.","authors":"Talha Soorma, Luciane Dreher Irion, Andrew James Walkden, Amira Stylianides","doi":"10.1177/11206721251372393","DOIUrl":"https://doi.org/10.1177/11206721251372393","url":null,"abstract":"<p><p>IntroductionConjunctival involvement in sarcoidosis typically presents as non-scarring granulomatous inflammation; however, cicatricial conjunctivitis represents a rare and poorly characterised manifestation. There are currently no published reports of sarcoid-related conjunctival granulomas with cicatrising features responding to anti-TNF therapy. We present the first case of biopsy-confirmed conjunctival sarcoidosis with progressive scarring successfully treated with adalimumab after failure of conventional immunosuppression.Case DescriptionA 47-year-old male with biopsy-proven systemic sarcoidosis presented with recurrent anterior uveitis and progressive conjunctival granulomas, unresponsive to corticosteroids and mycophenolate. He developed forniceal foreshortening, symblepharon formation, and a dense cataract. Conjunctival biopsy confirmed non-necrotizing granulomatous inflammation. Adalimumab was initiated following disease progression on conventional therapy. Within six months, ocular surface inflammation resolved, enabling successful cataract surgery and visual rehabilitation.ConclusionTo our knowledge, this is the first documented case of sarcoid-related cicatricial conjunctivitis with histological confirmation responding favourably to anti-TNF therapy. This report suggests adalimumab may be a valuable option in cases of treatment-resistant ocular surface sarcoidosis and may guide future therapeutic decision-making.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251372393"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sinonasal mucosal melanoma presenting with ocular symptoms: Two case reports and a literature review.","authors":"Kelsey Donovan, Narmien Murdock, Marielle Mahan, Viraj Mehta","doi":"10.1177/11206721251370912","DOIUrl":"https://doi.org/10.1177/11206721251370912","url":null,"abstract":"<p><p>PurposeSinonasal mucosal melanoma (SNMM) accounts for approximately 4-8% of sinonasal malignancies. SNMM frequently originates in the nasal cavity, causing nonspecific nasal symptoms that inevitably delay diagnosis. Left untreated, the tumor may extend into the orbit.Case DescriptionHerein, the authors describe two patients presenting with compressive optic neuropathy and were found to have advanced SNMM involving the orbit. Both patients presented with vision loss, decreased color vision, proptosis, conjunctival chemosis, and restricted extraocular movements. One patient was found to have a relative afferent pupillary defect. Neither patient was a surgical candidate, and both received palliative radiotherapy and immunotherapy.ConclusionsThese cases and literature review demonstrate the potential for the disease to initially manifest with orbital extension and ocular symptoms. Ophthalmologists can play a crucial role in the early detection of SNMM, which may improve outcomes, given the challenges of SNMM treatment.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251370912"},"PeriodicalIF":1.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cataract global burden of adolescents and young adults between 1990 and 2021: Analyses of the Global Burden of Disease Study 2021.","authors":"Lobsang Tshedron, Zijing Li","doi":"10.1177/11206721251370911","DOIUrl":"https://doi.org/10.1177/11206721251370911","url":null,"abstract":"<p><p>PurposeTo investigate the trend of cataract burden in individuals aged 15 to 39 years from 1990 to 2021.MethodsThis cross-sectional study leveraged data from the Global Burden of Disease Study 2021. The analysis included prevalence and disability-adjusted life years (DALYs) rates, along with the associated estimated annual percentage changes (EAPCs), assessed at the global level and categorized by sex, sociodemographic index (SDI), geographic region, and country.ResultsIn 2021, the global age-standardized prevalence rate (ASPR) was 51.095 per 100,000. From 1990 to 2021, the ASPR decreased by 5.615% (95% UI, -12.772 to 1.747%), with an EAPC of -0.379 (95% CI, -0.442 to -0.316). The age-standardized DALYs rate (ASDR) in 2021 was 5.541 per 100,000, decreasing by 20.498% (95% UI, -25.969 to -14.292), with an EAPC of -0.959 (95% CI, -1.041 to -0.877). The reductions in EAPC for ASPR and ASDR were more pronounced in males than in females. The high-SDI region exhibited the greatest increase in the EAPC of ASPR (0.219, 95% UI, 0.096 to 0.342) and generally remained stable in the EAPC of ASDR (0.024, 95% UI, -0.135 to 0.183). However, the low-middle-SDI region showed the greatest decrease in ASPR (EAPC: -1.246, 95% UI, -1.325 to -1.167) and ASDR (EAPC: -1.889, 95% UI, -1.974 to -1.804). Central Europe had the sharpest rise in both ASPR and ASDR among the 21 geographic regions, while South Asia saw the steepest decline. At the country level, the Central African Republic exhibited the largest increase, while Equatorial Guinea showed the greatest decrease in both ASPR and ASDR.ConclusionOver the past 32 years, the global burden of cataracts among adolescents and young adults has decreased; however, it remains a significant public health concern worldwide. Cost-effective and targeted strategies are needed to alleviate this burden.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251370911"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anchal Thakur, Divya Challa, Archana Angrup, Dipankar De, Sonam Yangzes, Chintan Malhotra, Amit Gupta
{"title":"Acute corneal hydrops secondary to acquired syphilis.","authors":"Anchal Thakur, Divya Challa, Archana Angrup, Dipankar De, Sonam Yangzes, Chintan Malhotra, Amit Gupta","doi":"10.1177/11206721251370906","DOIUrl":"https://doi.org/10.1177/11206721251370906","url":null,"abstract":"<p><p>PurposeTo report a rare case of acute corneal hydrops and conjunctival ulceration secondary to acquired syphilis.MethodsA male in his late 30's presented with redness, pain, and watering in both eyes and sudden loss of vision in the left eye. Examination revealed bilateral conjunctival ulcers along with well-circumscribed corneal edema with blunt stunted intrinsic vessel in the left eye. Anterior-Segment Optical Coherence Tomography revealed immense corneal edema with stunted vessels suggestive of acute hydrops.ResultsTopical moxifloxacin with oral doxycycline was administered along with oral acetazolamide. The patient's serology (VDRL) was positive with Treponema Pallidum Hemagglutination Assay positivity. Intramuscular benzathine penicillin injections (weekly; 3 injections) were given and subsequently, there was complete resolution with corneal scarring and restoration of vision to 20/60 in the left eye.ConclusionThis is the first case to illustrate acute hydrops as a presenting sign of ocular syphilis.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251370906"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of cognitive function in the reliability and results of standard automated perimetry.","authors":"Joel Pitkänen, Johanna Liinamaa, Ville Saarela","doi":"10.1177/11206721251369918","DOIUrl":"https://doi.org/10.1177/11206721251369918","url":null,"abstract":"<p><p>PurposeTo investigate the association between cognitive function and the results and reliability of standard automated perimetry (SAP) in a middle-aged birth cohort.MethodsIn this cross-sectional analysis of the prospective birth cohort, the reliability and performance of SAP were evaluated in relation to grade point average (GPA), educational attainment, and scores on the Paired Associates Learning (PAL) test among participants of the Northern Finland Birth Cohort Eye Study.ResultsHigher educational level, higher GPA, and fewer errors on the PAL test were consistently associated with better reliability and performance in SAP. However, the observed correlation coefficients were low, and differences between group comparisons were modest, accounting for only a small proportion of the variance in SAP outcomes.ConclusionWhile greater cognitive ability is positively associated with SAP performance and reliability, its impact is minimal and unlikely to be clinically significant. Further studies are warranted to determine whether higher cognitive function facilitates glaucoma diagnosis and monitoring through more reliable SAP results, or conversely, whether it may obscure glaucomatous damage by enhancing test performance beyond what is typical.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251369918"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alicja Strzalkowska, Piotr Strzalkowski, Leon Daniello, Esther M Hoffmann, Norbert Pfeiffer, Alexander K Schuster
{"title":"Evaluating surgical experience in trabeculectomy: Insights from a single-surgeon learning curve.","authors":"Alicja Strzalkowska, Piotr Strzalkowski, Leon Daniello, Esther M Hoffmann, Norbert Pfeiffer, Alexander K Schuster","doi":"10.1177/11206721251370056","DOIUrl":"https://doi.org/10.1177/11206721251370056","url":null,"abstract":"<p><p>PurposeThe aim of our study was to evaluate the outcome of trabeculectomy with respect to surgeon's experience and to explore additional contributing factors.MethodsThis retrospective study was conducted analyzing consecutive single-surgeon cases from October 2019 to June 2022 receiving TE with mitomycin C. Eyes were categorized into five groups based on surgeon experience: E1 for the first 50 TEs, E2 for 51-100, E3 for 101-150, E4 for 151-200, E5 for 201-300. Complete success at one year was defined as an IOP <18 mmHg and 20%-IOP reduction without glaucoma eye drops and revision surgeries.Results300 eyes were included (mean age 68.8 ± 13.0 years, 58.3% female). 55.7% had primary open-angle glaucoma. The baseline IOP was 23.4 ± 8.7 mmHg with 3.0 ± 0.9 different antiglaucomatous medication. After 12 months, the complete success for E1 to E5, it was 83.0%, 86.7%, 87.4%, 75.3% and 79.1% (<i>p</i> < 0.0001) with IOP 12.8 ± 6.1, 12.8 ± 6.3, 11.5 ± 4.6, 12.9 ± 6.5, 12.9 ± 4.7 mmHg while there was a higher number of NTG cases in E4 and E5 (<i>p</i> = 0.04).ConclusionsEven a novice surgeon can achieve a good surgical outcome within the first 50 trabeculectomy under the guidance of an experienced surgeon. When comparing surgical results over time, it is important to incorporate case entity and severity.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251370056"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohamad Reza Akbari, Masoud Khorrami-Nejad, Aiham Ali Mohammed, Foroozan Narooie-Noori, Reza Yousefi, Saba Javadi
{"title":"Clinical features and refractive profile of surgical patients with dissociated vertical deviation.","authors":"Mohamad Reza Akbari, Masoud Khorrami-Nejad, Aiham Ali Mohammed, Foroozan Narooie-Noori, Reza Yousefi, Saba Javadi","doi":"10.1177/11206721251367570","DOIUrl":"10.1177/11206721251367570","url":null,"abstract":"<p><p>BackgroundTo report the deviation type, visual and refractive characteristics of patients with dissociated vertical deviation (DVD) requiring unilateral or bilateral strabismus surgery.MethodsThis study included 180 patients with DVD who underwent unilateral or bilateral strabismus surgery at Farabi Eye Hospital.Age, refractive error (RE), Corrected distance visual acuity (CDVA), strabismus angle, presence of amblyopia, and postoperative outcome.ResultsThirty-eight patients were in unilateral (78.9% bilateral) group. In the unilateral group, CDVA was significantly worse in surgical eyes versus fellow eyes (<i>P</i> < .001). The mean spherical equivalent in surgical eyes was insignificantly hyperopic than fellow eyes (<i>P</i> <i>=</i> 0.354). The mean angle of DVD was greater at distance than near (P < .05). Furthermore, the most prevalent type was \"DVD plus horizontal deviation\" (47.4%), followed by pure DVD (23.7%), \"combined DVD, hypertropia (HT) and horizontal deviation\" (13.2%), and \"HT plus DVD\" (15.8%). CDVA in cases needing bilateral surgery in the right and left eye were 0.91 ± 0.17 and 0.90 ± 110.17, respectively.In the bilateral group, RE components were similar between eyes but lower than surgical eyes in patients with unilateral surgery (<i>P</i> < .05). Moreover, the mean angle of DVD was higher at a distance compared to near.The most prevalent type was \"DVD plus horizontal deviation\" (64.1%), followed by pure DVD (18.3%), \"combined DVD, HT and horizontal deviation\" (13.4%), and \"HT plus DVD\" (4.2%).ConclusionsThe study highlighted significant differences in VA, RE, and prevalence of amblyopia between the two groups.Furthermore, the varying types of coexisting deviations observed in unilateral and bilateral surgery cases emphasize the importance of personalized treatment approaches for patients with DVD.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251367570"},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Palak R Patel, Rohan A Jalalizadeh, Bradley T Smith
{"title":"Choroidal thickness as a clinical marker in differentiating peripheral retinoschisis and retinal detachments.","authors":"Palak R Patel, Rohan A Jalalizadeh, Bradley T Smith","doi":"10.1177/11206721251364120","DOIUrl":"10.1177/11206721251364120","url":null,"abstract":"<p><p>AimTo determine the value of central choroidal thickness (CCT) as a clinical marker in differentiating peripheral retinoschisis (PRS) and macula-on rhegmatogenous retinal detachments (mac-on RRD).MethodsIn this cross-sectional study, eyes with PRS from January 2012 to May 2021 and mac-on RRD from January 2017 to January 2019 were identified. Macular pathology was exclusionary. CCT was classified as thin, normal, or thick for all eyes. Primary outcomes assessed the proportion of eyes within each diagnostic category with thin, normal, and thick CCT.ResultsOne-hundred and sixty eyes with PRS and 59 eyes with mac-on RRD were identified. Thick (65.6%) or normal (25.0%) CCT was noted in 90.6% of eyes with PRS, while only 9.4% had thin CCT. Thin (52.5%) or normal (30.5%) CCT was noted in 83.0% of eyes with mac-on RRD, whereas only 17.0% had thick CCT's. Thick CCT was significantly observed in PRS (<i>p</i> < 0.0001), while thin CCT was significantly observed in mac-on RRD (<i>p</i> < 0.0001).ConclusionIn the absence of known refractive error or axial length, CCT may serve as a useful and readily available diagnostic tool when attempting to distinguish between two often clinically similar retinal pathologies - PRS and mac-on RRD.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251364120"},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of malnutrition on pupillary responses in pediatric population.","authors":"Dilara Özkoyuncu Kocabas, Fuat Yavrum, Elmas Yüksel Şükün, Begüm Yavrum","doi":"10.1177/11206721251367568","DOIUrl":"https://doi.org/10.1177/11206721251367568","url":null,"abstract":"<p><p>PurposeTo investigate the effect of nutritional status on pupillary responses in children aged 5 to 18 years.MethodsThis cross-sectional study comprised 92 eyes of malnourished children and 80 eyes of age- and gender-matched healthy children based on BMI Z-score. Serum ferritin, hemoglobin, serum 25-hydroxyvitamin D, and vitamin B12 levels were recorded. Pupillary responses were taken using Sirius topography (CSO, Italy) with the automated pupillometry function. Static pupillometry consisted of pupil diameters at scotopic, mesopic, and photopic luminances. In dynamic pupillometry, the mean pupil dilation speed at the 10th second was calculated by dividing the distance by time in each 0.2 s period.ResultsNo significant difference was observed between the groups regarding age, gender, visual acuity, and spherical equivalent (p > 0.05). Mean hemoglobin, serum ferritin, serum 25-hydroxyvitamin D, and vitamin B12 levels were lower in malnourished children than healthy children (p < 0.001). The malnutrition group had lower mean pupil diameters under all luminance and higher speed of pupil dilation compared to the control group (p < 0.05). While malnutrition subgroups were similar in terms of pupil diameters under all luminance (p > 0.05), the speed of pupil dilation was significantly different between the groups (p = 0.024). BMI z-score was positively correlated with mesopic and photopic pupil diameter but also negatively correlated with the speed of pupil dilation (p < 0.05).ConclusionMalnourished children have smaller pupil diameters and higher speed of pupil dilation than healthy controls, indicating an autonomic impairment.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251367568"},"PeriodicalIF":1.4,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}