European Journal of Ophthalmology最新文献_第10页

Pro Re Nata brolucizumab for early onset and treatment-naïve diabetic macular edema: A prospective study. Pro Re Nata brolucizumab 用于治疗早期和治疗无效的糖尿病黄斑水肿：一项前瞻性研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-14 DOI: 10.1177/11206721241276576

Alper Bilgic, Laurent Kodjikian, Aditya Sudhalkar, Jesus Hernan Gonzalez-Cortes, Francesc March de Ribot, Riddhima Deshpande, Martin S Spitzer, Thibaud Mathis

{"title":"Pro Re Nata brolucizumab for early onset and treatment-naïve diabetic macular edema: A prospective study.","authors":"Alper Bilgic, Laurent Kodjikian, Aditya Sudhalkar, Jesus Hernan Gonzalez-Cortes, Francesc March de Ribot, Riddhima Deshpande, Martin S Spitzer, Thibaud Mathis","doi":"10.1177/11206721241276576","DOIUrl":"https://doi.org/10.1177/11206721241276576","url":null,"abstract":"Objectives: To determine the efficacy and safety of brolucizumab therapy administered on a pro re nata (PRN) basis without loading dose in treatment naïve patients with diabetic macular edema (DME) for 1 year follow-up.Methods: Patients with recent DME (<6 months) received a mandatory brolucizumab injection at inclusion and other injections could be given on a PRN basis with an 8-week interval (between injections) at minimum. Rescue therapy with other anti-VEGF was possible in case of incomplete DME resolution after the second brolucizumab with a minimum of 1-month treatment free interval between 2 injections. The primary outcome measure was the change in (BCVA) at 12 months. Secondary outcome measures included the change in central subfield thickness (CST), the change in hard exudate surface area and microaneurysms at 1 year.Results: A total of 53 patients were included. At 12 months, the mean (SD) number of injections was 2.6 (0.8) in addition to the first mandatory injection. The mean (SD) interval between 2 consecutive injections was 3.2 (1.4) months. The mean (SD) BCVA improved from 0.62 (0.1) logMAR to 0.40 (0.16) logMAR (p = 0.012). The mean CST reduced from 397.0 (47.2) µm to 224.5 (28.1) µm (p = 0.013). The hard exudate surface area decreased significantly (p = 0.012) as did microaneurysms (p = 0.02). Seven patients required at least 1 rescue therapy. No patients experienced intra-ocular inflammatory adverse events.Conclusion: Brolucizumab therapy for DME is a safe and effective modality for the treatment of recent DME and has the potential to reduce the number of injections.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Reactive Astrocytic Tumor and Astrocytic hamartomas in patient with Neurofibromatosis type 1: Case Report and Literature review. 神经纤维瘤病 1 型患者视网膜反应性星形胶质细胞瘤和星形胶质细胞瘤：病例报告和文献综述。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-14 DOI: 10.1177/11206721241275143

Theodora Hadjistilianou, Alberto Carnicci, Carlo D'Alessandro, Sonia De Francesco, Mario Fruschelli

引用次数: 0

Diagnostic ability of the corneal anterior and posterior surface area calculated by corneal modelling approach in early stage keratoconus patients. 用角膜建模法计算早期角膜炎患者的角膜前后表面积的诊断能力。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-14 DOI: 10.1177/11206721241272151

Bahadır Özelbaykal, Ozan Kaya, Burcu Kasım, Tolga Birkandan, Yusuf Koçluk

{"title":"Diagnostic ability of the corneal anterior and posterior surface area calculated by corneal modelling approach in early stage keratoconus patients.","authors":"Bahadır Özelbaykal, Ozan Kaya, Burcu Kasım, Tolga Birkandan, Yusuf Koçluk","doi":"10.1177/11206721241272151","DOIUrl":"https://doi.org/10.1177/11206721241272151","url":null,"abstract":"Purpose: To investigate the discrimination ability of the corneal anterior and posterior surface area between patients with keratoconus stage 1 and normal individuals.Methods: In this retrospective study, 116 eyes of 116 normal individuals and 366 eyes of 366 keratoconus patients were included. Keratoconus patients were divided into six groups according to the topographic keratoconus classification of Pentacam. Anterior and posterior surface data of sagittal (SM) and elevation maps (EM) were exported from Pentacam, and human corneal models were created employing the software utilizing the PyVista module of Python programming language. The anterior and posterior corneal surface area (a-CSA and p-CSA) of SM and EM were calculated by the software ranging from central 3 to 8mm diameter.Results: Anterior and posterior CSA values were higher in KC patients compared to normal individuals (p < 0.001). The p-CSA for SM and EM measured at the central 3mm was higher in patients with KC-1 compared to normal eyes (p = 0.002, p = 0.005, respectively), For both maps, a-CSA and p-CSA measured at the central 4 and 5mm were higher in KC-1 compared to normal individuals (p < 0.05). The highest area under the curve (AUC) values in the diagnosis patients with KC-1 were obtained from 3mm p-CSA for SM (AUC: 0.8338), 3mm p-CSA for EM (AUC: 0.7999), 4mm p-CSA for SM (AUC: 0.8531), 4mm p-CSA for EM (AUC:0.7948), 5mm p-CSA for SM (AUC: 0.8455), 5mm p-CSA for EM (AUC:0.7614).Conclusion: The corneal surface area as a parameter, especially for central 3, 4, and 5mm, has a discrimination ability in diagnosing keratoconus disease and distinguishes normal eyes from KC-1 eyes.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A bibliometric and citation network analysis of crosslinking. 交叉链接的文献计量学和引文网络分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-14 DOI: 10.1177/11206721241272177

Miguel Ángel Sánchez-Tena, Clara Martínez Pérez, Cesar Villa-Collar, Cristina Alvarez-Peregrina

{"title":"A bibliometric and citation network analysis of crosslinking.","authors":"Miguel Ángel Sánchez-Tena, Clara Martínez Pérez, Cesar Villa-Collar, Cristina Alvarez-Peregrina","doi":"10.1177/11206721241272177","DOIUrl":"https://doi.org/10.1177/11206721241272177","url":null,"abstract":"Purpose: Research on crosslinking has focused mainly on trying to slow the progression of keratoconus. The objective of this bibliometric analysis is to determine the relationships between the different publications and authors. As well as to identify the different areas of research on crosslinking. Methods: Web of Science (WOS) was the database for the search of publications for the period 1972 to December 2023, using the terms: crosslinking, cross-linking, ocular, vision, visual, cornea, ectasia AND Keratoconus. The analysis of the publication was performed using the CitNetExplorer, VOSviewer and CiteSpace software. Results: 7161 publications and 59415 citation networks were found. The year with the most publications is 2021, a total of 571 (7.97%) publications and 135 citation networks. The most cited publication was \"Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus\" published by Wollensak et al. in 2003, with a citation index of 1780. Using the Clustering function, five groups were found that cover the main research areas in this field: keratoconus, corneal transplantation, cataracts, corneal inflammation and axial growth. Conclusion: The treatment of keratoconus continues to be the topic of interest in this area of research. However, in recent years there has been an increase in research on how crosslinking helps to slow down axial growth.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bubble-graft coverage after Descemet Membrane Endothelial Keratoplasty depending on gaze angle. 视注视角度而定的 Descemet 膜内皮角膜移植术后气泡移植覆盖率。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-09 DOI: 10.1177/11206721241267277

Maximilian Friedrich, Hyeck-Soo Son, Rebecca Charlotte Buhl, Christine Maria Meyer, Timur Mert Yildirim, Ramin Khoramnia, Gerd Uwe Auffarth, Victor Aristide Augustin

{"title":"Bubble-graft coverage after Descemet Membrane Endothelial Keratoplasty depending on gaze angle.","authors":"Maximilian Friedrich, Hyeck-Soo Son, Rebecca Charlotte Buhl, Christine Maria Meyer, Timur Mert Yildirim, Ramin Khoramnia, Gerd Uwe Auffarth, Victor Aristide Augustin","doi":"10.1177/11206721241267277","DOIUrl":"https://doi.org/10.1177/11206721241267277","url":null,"abstract":"Purpose: In Descemet Membrane Endothelial Keratoplasty (DMEK) a gas bubble is usually used to attach the graft to the host cornea. In this study, we observed the bubble size and bubble-graft coverage at different gaze angles following DMEK.Methods: This observational prospective study analyzed 465 images of patients who underwent an uneventful DMEK. Intraoperatively, the anterior chamber was filled up to 90% of its volume with a 20% Sulfur Hexafluoride (SF6) gas-air mixture. Postoperatively, the bubble was photographed daily in different gaze angles ranging from a supine position (0°) to an upright position (90°) and a slightly inclined position (105°). The primary outcomes were bubble-graft coverage and bubble diameters depending on the gaze angle and time after DMEK.Results: The highest bubble-graft coverage was achieved at a 0° gaze angle at all times of measurement. In the first 48 h after DMEK, the mean bubble-graft coverage was over 85% at a gaze angle between 0° and 45°. Starting 72 h after DMEK, the graft coverage declined at all gaze angles. The graft coverage at a 0° gaze angle was 88.61 ± 10.90% after 96 postoperative hours, while the graft coverage was below 85% at all other gaze angles.Conclusion: Our clinical results provide novel insight into variation in bubble-graft coverage as a function of gaze angle and may be used to aid in patient counselling for appropriate body positioning following DMEK to prevent early graft detachment. Maintaining supine positioning seems to be most advantageous starting 48 h after DMEK.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Year comparative analysis between standalone iStent implantation versus combined iStent implantation with phacoemulsification. 独立 iStent 植入术与联合 iStent 植入术和超声乳化术的一年期比较分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-07 DOI: 10.1177/11206721241273678

Phong Yue Khoo, Seng Fai Tang, Chenshen Lam, Teck Chee Cheng, Norshamsiah Md Din

{"title":"One-Year comparative analysis between standalone iStent implantation versus combined iStent implantation with phacoemulsification.","authors":"Phong Yue Khoo, Seng Fai Tang, Chenshen Lam, Teck Chee Cheng, Norshamsiah Md Din","doi":"10.1177/11206721241273678","DOIUrl":"https://doi.org/10.1177/11206721241273678","url":null,"abstract":"Purpose: To evaluate the real-world efficacy and safety of iStent implanted standalone or combined with phacoemulsification in open-angle glaucoma (OAG) patients.Methods: This is a retrospective observational study of OAG patients who underwent standalone or combined iStent procedures were reviewed. Inclusion criteria included age over 18 years and open angle on gonioscopy. Exclusion criteria were prior incisional glaucoma surgeries, missing data, or follow-up shorter than 6 months. The primary outcome was surgical success between the two groups after one year. Secondary outcomes included differences in IOP reduction and medication use.Results: We included 48 eyes with primary (n = 44) and secondary OAG (n = 4). Nineteen eyes had standalone while 29 eyes had combined procedures. Kaplan-Meier analysis revealed overall surgical success in 31.3% of eyes after one year. Qualified success was higher in the combined group than the standalone group [62.5% (10 eyes) vs 27.3% (3 eyes), p = 0.239]. At 24 months, mean IOP reduced by 2.2 ± 2.5 mmHg vs 3.3 ± 2.9 mmHg, p = 0.333), and the number of medications reduced by 1.1 ± 1.2 vs 1.3 ± 0.1, p < 0.001) in the standalone and combined group, respectively. Stent occlusion occurred in two eyes.Conclusions: While both standalone and combined iStent procedures provide safe IOP reduction throughout 12 months, there was no statistically significant difference in surgical success between them.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modified viscotrabeculotomy versus modified trabeculotomy in late-onset primary congenital, juvenile, and secondary open-angle glaucoma. 晚发性原发性先天性、青少年和继发性开角型青光眼中的改良黏液小梁切开术与改良小梁切开术。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-07 DOI: 10.1177/11206721241273977

Ghasem Fakhraie, Shabnam Ansari, Seyed Mehdi Tabatabaei, Nikoo Hamzeh, Zakieh Vahedian, Alireza Beikmarzehei

{"title":"Modified viscotrabeculotomy versus modified trabeculotomy in late-onset primary congenital, juvenile, and secondary open-angle glaucoma.","authors":"Ghasem Fakhraie, Shabnam Ansari, Seyed Mehdi Tabatabaei, Nikoo Hamzeh, Zakieh Vahedian, Alireza Beikmarzehei","doi":"10.1177/11206721241273977","DOIUrl":"https://doi.org/10.1177/11206721241273977","url":null,"abstract":"Purpose: To compare modified viscotrabeculotomy (VCO-Tbo) to modified trabeculotomy (Tbo) in late-onset primary congenital, juvenile open-angle, steroid-induced, and pigmentary glaucoma.Methods: Patients were randomly assigned to VCO-Tbo and Tbo groups in this study. Intraocular pressure (IOP), antiglaucoma medications, and success/failure rates were assessed. A linear mixed model was used to compare the change trend at different follow-up times. Survival time was evaluated using the Kaplan-Meier graph and Log-Rank test.Results: The mean IOP at 1, 3, and 12 months in the VCO-Tbo group was 14.1 ± 3.1, 15.9 ± 3 and 17 ± 3.1 mmHg, respectively. The mean IOP at the same time points in the Tbo group was 15.9 ± 3.3, 17.6 ± 3.5 and 18.4 ± 3.2 mmHg (P = 0.051, 0.058, 0.088, respectively). The VCO-Tbo group had significantly lower IOP after six months (16.5 ± 4.1 mmHg vs. 18.7 ± 3.8 mmHg; p = 0.031) and by the last visit (16.8 ± 2.1 mmHg vs. 18.8 ± 2 mmHg; p = 0.013). The reduction in the number of medications was significant in both groups compared to baseline (P < 0.001), but there was no significant difference between groups (P = 0.450). The complete and qualified success rate was 43.9% and 34.1% in the VCO-Tbo group and 46.8% and 10.6% in the Tbo group at the final follow-up (p = 0.040, and 0.039, respectively).Conclusion: Both procedures are effective in IOP and medication reduction. The survival time and efficacy of modified trabeculotomy can be augmented by injecting cohesive viscoelastic in the Schlemm's canal.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between persistence with topical antiglaucomatous prescription and patient socioeconomic status at a tertiary university hospital in Jerez de la Frontera (Spain). 西班牙赫雷斯德拉弗龙特拉一家三级甲等大学医院的局部抗青光眼处方持续性与患者社会经济地位之间的关系。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-07 DOI: 10.1177/11206721241272239

Ignacio Pereira-Gonzalez, Javier Benitez-Del-Castillo Sanchez, Soledad Jimenez Carmona, Juan Antonio Cordoba Doña

{"title":"Relationship between persistence with topical antiglaucomatous prescription and patient socioeconomic status at a tertiary university hospital in Jerez de la Frontera (Spain).","authors":"Ignacio Pereira-Gonzalez, Javier Benitez-Del-Castillo Sanchez, Soledad Jimenez Carmona, Juan Antonio Cordoba Doña","doi":"10.1177/11206721241272239","DOIUrl":"https://doi.org/10.1177/11206721241272239","url":null,"abstract":"Introduction: To study the relationship between socioeconomic status and persistence with topical antiglaucomatous medication.Methods: A retrospective epidemiological observational cohort study was conducted with a sample of 1563 patients. The main dependent variable was persistence (medication possession ratio), the independent variable was socioeconomic status (deprivation index). Additional independent variables were used for multivariate analysis: individual health card index, sex, age, pharmacological group, number of eye drops, preservatives, diagnosis and concurrent medications. Bivariate statistical analysis was obtained using non-parametric tests. Logistic regression was used for multivariate analysis. The level of statistical significance was set at p < 0.05.Results: We obtained data showing greater persistence in the groups with a higher socioeconomic level (deprivation index 1 and 2), with medication possession ratio values of 79.97 and 75.30, respectively) as opposed to the groups at lower socioeconomic levels (deprivation index 4 and 5, with medication possession ratio values of 73.75 and 69.85, respectively. Logistic regression corroborated this difference, reaching a significant value (no persistence in deprivation index group 5 versus 1) with OR = 1.62; 95%CI: 1.13-2.31. Additionally, lower persistence was detected in males, under 60 years of age, undergoing treatment with alpha-agonists, and in patients with ocular hypertension.Discussion: Low socioeconomic status of the patient was significantly associated with decreased persistence with topical antiglaucomatous therapy.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular and adnexal injuries after two major earthquakes in Turkey on February 6, 2023. 2023 年 2 月 6 日土耳其两次大地震后的眼部和附件损伤。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-07 DOI: 10.1177/11206721241272204

Melike Şensoy, Nurettin Bayram, Eyupcan Sensoy, Kenan Sonmez

{"title":"Ocular and adnexal injuries after two major earthquakes in Turkey on February 6, 2023.","authors":"Melike Şensoy, Nurettin Bayram, Eyupcan Sensoy, Kenan Sonmez","doi":"10.1177/11206721241272204","DOIUrl":"https://doi.org/10.1177/11206721241272204","url":null,"abstract":"Purpose: This study aimed to determine the forms of ocular and adnexal injuries and to examine the treatment modalities applied after two major earthquakes in Turkey on February 6, 2023.Methods: Following the earthquakes, the medical records of 34 patients admitted with emergency ophthalmic complaints to Hatay Training and Research Field Hospital and Etlik City Hospital were retrospectively reviewed. Of these patients, 35 eyes of 34 individuals diagnosed with earthquake-related ocular and adnexal injuries were included in the study. Demographic characteristics were recorded, including ocular and adnexal findings, treatment modalities, and postoperative complications.Results: Of the patients, 16 (47.1%) were female, and 18 (52.9%) were male. The mean age was 37.38 ± 17.3 years. The mean time from the earthquake to the first admission to the hospital was 3.82 ± 1.78 days. Initial and final best-corrected visual acuities (BCVA) were 0.54 ± 0.66 logMAR and 0.22 ± 0.41 logMAR, respectively (p = 0.0003). The initial and final BCVA of 2 eyes was no light perception. The most common forms of ocular/periocular injury associated with earthquakes were eyelid laceration (n:25, 71.4%) and orbital fracture (n:17, 48.6%). The most common accompanied systemic trauma was extremity/rib fractures (38.2). The most frequently performed surgery was the primary repair of the eyelid/canalicular (n:17, 48.6%).Conclusion: While earthquake-related ocular and adnexal traumas are relatively uncommon, understanding the specific injury types, promptly identifying cases requiring urgent intervention, and mastering effective treatment modalities are essential for minimizing the risk of severe permanent visual impairment in these patients.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diabetic retinopathy screening with confocal fundus camera and artificial intelligence - assisted grading. 利用共焦眼底照相机和人工智能辅助分级筛查糖尿病视网膜病变。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2024-08-07 DOI: 10.1177/11206721241272229

A Piatti, C Rui, S Gazzina, B Tartaglino, F Romeo, R Manti, M Doglio, E Nada, C B Giorda

{"title":"Diabetic retinopathy screening with confocal fundus camera and artificial intelligence - assisted grading.","authors":"A Piatti, C Rui, S Gazzina, B Tartaglino, F Romeo, R Manti, M Doglio, E Nada, C B Giorda","doi":"10.1177/11206721241272229","DOIUrl":"https://doi.org/10.1177/11206721241272229","url":null,"abstract":"Purpose: Screening for diabetic retinopathy (DR) by ophthalmologists is costly and labour-intensive. Artificial Intelligence (AI) for automated DR detection could be a clinically and economically alternative. We assessed the performance of a confocal fundus imaging system (DRSplus, Centervue SpA), coupled with an AI algorithm (RetCAD, Thirona B.V.) in a real-world setting.Methods: 45° non-mydriatic retinal images from 506 patients with diabetes were graded both by an ophthalmologist and by the AI algorithm, according to the International Clinical Diabetic Retinopathy severity scale. Less than moderate retinopathy (DR scores 0, 1) was defined as non-referable, while more severe stages were defined as referable retinopathy. The gradings were then compared both at eye-level and patient-level. Key metrics included sensitivity, specificity all measured with a 95% Confidence Interval.Results: The percentage of ungradable eyes according to the AI was 2.58%. The performances of the AI algorithm for detecting referable DR were 97.18% sensitivity, 93.73% specificity at eye-level and 98.70% sensitivity and 91.06% specificity at patient-level.Conclusions: DRSplus paired with RetCAD represents a reliable DR screening solution in a real-world setting. The high sensitivity of the system ensures that almost all patients requiring medical attention for DR are referred to an ophthalmologist for further evaluation.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0