European Journal of Ophthalmology最新文献_第9页

Refining delivery and positioning: A modified approach to FIL SSF intraocular lens implantation using the "full reverse" technique. 改进输送和定位：使用 "完全反向 "技术进行 FIL SSF 眼内透镜植入的改良方法。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-10-15 DOI: 10.1177/11206721241291106

Enea Chisci, Giulia Torregrossa, Salvatore Torregrossa, Alberto La Mantia

{"title":"Refining delivery and positioning: A modified approach to FIL SSF intraocular lens implantation using the \"full reverse\" technique.","authors":"Enea Chisci, Giulia Torregrossa, Salvatore Torregrossa, Alberto La Mantia","doi":"10.1177/11206721241291106","DOIUrl":"10.1177/11206721241291106","url":null,"abstract":"Purpose: To present a modified surgical technique for implantation of the sutureless scleral-fixated hydrophilic intraocular lens (FIL SSF).Methods: Single surgeon retrospective case series and review of surgical videos with step-by-step technique analysis. Uncorrected and best corrected visual acuity (UCVA and BCVA), refractive error (spherical equivalent), full clinical examination with intraocular pressure (IOP) measurement, endothelial cell density on corneal specular microscopy and macular optical coherence tomography (OCT) were recorded at baseline, 1, 4 and 8 weeks postoperatively.Results: The FIL SSF IOLs were successfully implanted using the so-called \"full reverse\" technique, having the lens loaded in the injector in an upside-down fashion, as opposed to IOL technical specifications. In all cases, the FIL SSF IOL was properly placed in the ciliary sulcus, well-centered and without signs of tilt. Follow up figures at 2 months are consistent with published data, confirming the potential benefits of the new implantation technique.Conclusion: In our preliminary experience, the \"full reverse\" technique of the FIL SSF IOL has proven effective in preventing incorrect IOL orientation in 100% of cases. However, larger prospective controlled studies and longer follow up are required to either support or disprove our results.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"753-759"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142461152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual deprivation and axial myopia: Considerations on long-term ocular development. 视力剥夺与轴型近视：对长期眼发育的思考。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2025-01-02 DOI: 10.1177/11206721241310624

Michele Rinaldi, Paolo Esposito Veneruso, Fausto Tranfa, Gaetano Fioretto, Salvatore Troisi, Maria Laura Passaro, Francesco Matarazzo, Ciro Costagliola

{"title":"Visual deprivation and axial myopia: Considerations on long-term ocular development.","authors":"Michele Rinaldi, Paolo Esposito Veneruso, Fausto Tranfa, Gaetano Fioretto, Salvatore Troisi, Maria Laura Passaro, Francesco Matarazzo, Ciro Costagliola","doi":"10.1177/11206721241310624","DOIUrl":"10.1177/11206721241310624","url":null,"abstract":"Introduction: Severe visual deprivation during infancy can lead to long-term changes in ocular development, including significant differences in axial length (AL) between eyes. This case report presents three adult patients with monocular infantile visual deprivation who developed substantial AL interocular differences. The aim is to explore the impact of early visual deprivation on AL and its potential implications for myopia progression.Case report: Three male patients, aged 19, 42, and 50, were evaluated at the Ophthalmology Department of the University Hospital of Naples \"Federico II.\" Each patient had a history of severe visual deprivation in one eye during infancy. The first patient experienced a dense corneal fibrovascular membrane from a chemical burn at age 1. The second suffered total corneal stromal scarring from a chemical burn at age 2. The third developed dense leukoma following infective keratitis at 0.3 years. Ophthalmological evaluations included refractive assessment, biomicroscopy, fundus examination (where feasible), electroretinogram (ERG), and A-Scan ultrasound. Affected eyes exhibited severe visual impairment (light perception in two patients, and 1.6 logMAR in the third), while the fundus could not be fully explored, and echographic assessment was used to exclude major chorioretinal changes. ERG findings were within normal limits, despite presumed early developmental impact on the retina due to lack of form vision. However, AL measurements revealed a 5.8-6.3 mm increase in the affected eyes compared to the healthy ones.Conclusion: Infantile severe visual deprivation can lead to significant interocular AL differences in adulthood. These findings underscore the importance of investigating the underlying mechanisms to better understand and manage myopia progression in similar cases.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP12-NP16"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Management of late postoperative capsular bag distension syndrome - two year case series. 术后晚期囊袋膨胀综合征的处理--两年病例系列。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/11206721241302440

Marianna Otrošinová, Jan Novák, Vladimír Krásnik

{"title":"Management of late postoperative capsular bag distension syndrome - two year case series.","authors":"Marianna Otrošinová, Jan Novák, Vladimír Krásnik","doi":"10.1177/11206721241302440","DOIUrl":"10.1177/11206721241302440","url":null,"abstract":"Introduction: Late capsular bag distension syndrome (CBS) is a rare complication of the ^lcataract surgery.Aim: The aim is to present 9 cases with delayed presentation and describe their successful management with surgical approach.Method: A two-year retrospective review of 9 cases was undertaken. Anterior segment optical coherence tomography (AS-OCT) was used to confirm this diagnosis. Aspiration of the milky fluid with 26 gauge needle followed by capsular bag lavage was performed and aspirated fluid was examined.Results: Patients showed signs of late CBS 6,56 ± 1,94 years after uncomplicated phacoemulsification with intraocular lens (IOL) implantation into the capsular bag. All 9 patients presented with a turbid fluid collection within the distended capsular bag. AS-OCT showed a hyper-reflective material in the space between the IOL and distended posterior capsule.Conclusion: Awareness of the manifestations of CBS and choice of the correct imaging modality may lead to regular diagnosis and successful treatment. Management with aspiration of the milky fluid and lavage of the capsular bag is technically safe and effective procedure. It has the advantage of microbial testing of the fluid. AS-OCT is useful tool to differentiate this condition clearly from IOL opacification and posterior capsule opacification.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP8-NP11"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Minimally Invasive Glaucoma Surgery (MIGS) recommendations in Clinical Practice Guidelines for open angle glaucoma and MIGS procedures: A scoping review. 微创青光眼手术（MIGS）在开角型青光眼临床实践指南和微创青光眼手术中的建议：范围审查。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-22 DOI: 10.1177/11206721241276223

Jose Galvez-Olortegui, Carmen Burgueño-Montañes, Isabel Silva-Ocas, Susan Bernales-Urbina, Tomas Galvez-Olortegui

{"title":"Minimally Invasive Glaucoma Surgery (MIGS) recommendations in Clinical Practice Guidelines for open angle glaucoma and MIGS procedures: A scoping review.","authors":"Jose Galvez-Olortegui, Carmen Burgueño-Montañes, Isabel Silva-Ocas, Susan Bernales-Urbina, Tomas Galvez-Olortegui","doi":"10.1177/11206721241276223","DOIUrl":"10.1177/11206721241276223","url":null,"abstract":"Introduction: To assess the recommendations of open angle glaucoma Clinical Practice Guidelines (CPG) addressing Minimally Invasive Glaucoma Surgery (MIGS) or MIGS procedures CPG. Methods: A scoping review of CPG was conducted, based on an ongoing systematic review (CRD42024510656). A systematic literature search of CPG was carried out in November 2023, with an update in January 2024. CPG published in the last 8 years, full text available and addressing MIGS were selected. CPG details and recommendations concerning MIGS were extracted. Results: 13 CPG addressing MIGS were selected (8 recovered from databases and 5 from registers). Four health Technology Assessments were assessed but recommendations were not considered. Finnish and Swedish guidelines, published in 2024, and Japanese guidelines, published in 2023, are English versions of their native language guidelines, but none of them make specific recommendations about MIGS. The Spanish Glaucoma Society - Advanced Glaucoma guideline (2023) describes the available techniques but does not make recommendations about MIGS. The European Glaucoma Society (2023) guideline only makes recommendations for 4 devices and the National Institute for Health and Care Excellence Interventional procedures guidance makes recommendations both for specific procedures and devices. Conclusion: MIGS is a relevant topic that has not been adequately addressed in terms of updated evidence, available procedures, and recommendations in open angle glaucoma CPG or MIGS procedures CPG.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"602-610"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142035557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproducibility of SIMPLE classification for diabetic retinopathy screening and its comparison to current Italian guidelines. 用于糖尿病视网膜病变筛查的 SIMPLE 分类的可重复性及其与意大利现行指南的比较。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-08-07 DOI: 10.1177/11206721241272230

Maria Carla Donati, Lorenzo Cifarelli, Alberto Morelli, Ludovica Alonzo, Ruggero Tartaro, Paola Sasso, Martina Maceroni, Angelo Maria Minnella, Stanislao Rizzo, Edoardo Mannucci, Valentina Vitale, Katie Curran, Tunde Peto, Fabrizio Giansanti, Gianni Virgili

{"title":"Reproducibility of SIMPLE classification for diabetic retinopathy screening and its comparison to current Italian guidelines.","authors":"Maria Carla Donati, Lorenzo Cifarelli, Alberto Morelli, Ludovica Alonzo, Ruggero Tartaro, Paola Sasso, Martina Maceroni, Angelo Maria Minnella, Stanislao Rizzo, Edoardo Mannucci, Valentina Vitale, Katie Curran, Tunde Peto, Fabrizio Giansanti, Gianni Virgili","doi":"10.1177/11206721241272230","DOIUrl":"10.1177/11206721241272230","url":null,"abstract":"Purpose: To evaluate the reproducibility of SIMPLE (Single field Image Multi Parameters defined Lesions Extent), a new Diabetic Retinopathy (DR) classification for screening of 45° single field fundus pictures of patients with diabetes (PwDM), assessing DR, Diabetic Maculopathy (DMac) and referral rate agreement and comparing it to current Italian Guidelines (IG).Materials and methods: We conducted a retrospective, observational, multicentre study, collecting 1000 retinal 45° single field images of PwDM obtained during routine visits in two diabetes clinics. Three ophthalmologists evaluated each image, determining the presence and number of specific DR lesions and then assigning a stage according to the current IG for screening. SIMPLE staging was performed automatically via Excel software, based on the pre-specified DR characteristics observed by the graders. We analysed intra-centre, inter-centre and total inter-grader agreement for DR and DMac stage and referral rate of the two classifications.Results: Agreement amongst the three graders was consistently higher when using SIMPLE classification than when using current IG classification. For DR, kappa (k) was 0.86 with IG and 0.95 with SIMPLE classification; for DMac, k-IG was 0.78, while k-SIMPLE was 0.96; concordance on the referral rate was 0.91 with IG and 0.99 with SIMPLE. Similar results were obtained in sub-analyses for the evaluation of intra-centre and inter-centre concordance.Conclusions: Our results suggest that the new SIMPLE classification has an excellent reproducibility amongst graders, comparable or superior to the current IG for DR screening proposed in 2015, improving the standardisation of the decision on referability.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"627-636"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful use of PRGF-endoret® and ILM peeling for full thickness macular hole in MacTel type 2: A case report and review of literature. 成功使用 PRGF-endoret® 和 ILM 剥离术治疗 MacTel 2 型全厚黄斑孔：病例报告和文献综述。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/11206721241301933

Yann Bertolani, Albert Arnaiz-Camacho, Jorge Fernández-Engroba, Jose García-Arumí, Miguel-Ángel Zapata

{"title":"Successful use of PRGF-endoret® and ILM peeling for full thickness macular hole in MacTel type 2: A case report and review of literature.","authors":"Yann Bertolani, Albert Arnaiz-Camacho, Jorge Fernández-Engroba, Jose García-Arumí, Miguel-Ángel Zapata","doi":"10.1177/11206721241301933","DOIUrl":"10.1177/11206721241301933","url":null,"abstract":"Purpose: To describe the successful use of plasma rich in growth factors (PRGF-Endoret®) and internal limiting membrane peeling for full thickness macular hole in Macular Telangiectasia type 2.Case presentation: A case report of a full thickness macular hole (FTMH) associated with Macular Telangiectasia (MacTel) type 2 is described. 25-G vitrectomy with internal limiting membrane (ILM) peeling and use of (PRGF-Endoret®) was performed. Several ophthalmological visits were conducted and multiple diagnostic tests were carried out including optical coherence tomography (OCT) and fluorescein angiography. A 72-year-old man under follow-up for MacTel type 2 presented with worsening vision in his left eye, with a best visual corrected acuity (BVCA) of 20/80. OCT demonstrated a FTMH in the left eye measuring 264 µm. A 25-gauge pars plana vitrectomy surgery was performed with ILM peeling, use of PRGF-Endoret® and tamponade with 20% sulfur hexafluoride (SF6). Three weeks after surgery, complete anatomical closure was observed with a BVCA of 20/40, which improved to 20/25 one year after the surgery.Conclusions: The use of PRGF associated with ILM peeling may be a useful tool in the treatment of macular holes associated with MacTel Type 2 with excellent anatomical and functional outcomes.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP33-NP38"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prechoroidal cleft changes after intravitreal injections of Faricimab in treatment-naïve and nonresponders-to-aflibercept patients: A case series. 在treatment-naïve和对aflibercept无反应的患者中，玻璃体内注射Faricimab后脉络膜前裂的变化：一个病例系列。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-02-26 DOI: 10.1177/11206721251322541

Elisa Stradiotto, Alessandro Feo, Giovanni Ottonelli, Vanessa Ferraro, Claudia Del Turco, Claudio Panico, Mario R Romano, Carlo La Spina

{"title":"Prechoroidal cleft changes after intravitreal injections of Faricimab in treatment-naïve and nonresponders-to-aflibercept patients: A case series.","authors":"Elisa Stradiotto, Alessandro Feo, Giovanni Ottonelli, Vanessa Ferraro, Claudia Del Turco, Claudio Panico, Mario R Romano, Carlo La Spina","doi":"10.1177/11206721251322541","DOIUrl":"https://doi.org/10.1177/11206721251322541","url":null,"abstract":"Purpose: To describe the clinical and optical coherence tomography (OCT) changes of prechoroidal cleft in treatment-naïve and non-naïve neovascular age-related macular degeneration (nAMD) treated with Faricimab intravitreal injections.Methods: A case series (4 eyes from 4 patients).Results: Cases 1 and 2 were diagnosed with treatment-naïve nAMD. Case 1 showed minimal prechoroidal cleft persistence after treatment with visual acuity stabilization. Case 2 showed prechoroidal cleft resolution, followed by its recurrence with neovascular reactivation. Cases 3 and 4 had a history of nAMD unresponsive to Aflibercept therapy. In Case 3, prechoroidal cleft reappearance occurred simultaneously to neovascular reactivation. In Case 4 prechoroidal cleft resolved rapidly after switching to Faricimab, but this was complicated by the development of a retinal pigment epithelium (RPE) tear.Conclusion: In this report, we highlight the importance of prechoroidal cleft as a negative prognostic OCT biomarker despite the increasingly proved efficacy of Faricimab. Pigment epithelium detachment height may correlate with the size of prechoroidal cleft and macular neovascularization (MNV) activity. Further studies are needed to better elucidate the prognostic significance of prechoroidal cleft after Faricimab therapy.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251322541"},"PeriodicalIF":1.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted shortwave diathermy combined with perceptual training for patients with severe traumatic optic neuropathy. 针对性短波热疗联合知觉训练治疗严重外伤性视神经病变。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-02-24 DOI: 10.1177/11206721251319574

Qingping Tang, Hua Zhang, Huayang Deng, Quan Zhou, Wei Zhang, Mingqin Tian, Zilong Huang, Hui Jiang, Weihong Jiang, Zhihai Xie

{"title":"Targeted shortwave diathermy combined with perceptual training for patients with severe traumatic optic neuropathy.","authors":"Qingping Tang, Hua Zhang, Huayang Deng, Quan Zhou, Wei Zhang, Mingqin Tian, Zilong Huang, Hui Jiang, Weihong Jiang, Zhihai Xie","doi":"10.1177/11206721251319574","DOIUrl":"https://doi.org/10.1177/11206721251319574","url":null,"abstract":"Background: Patients with severe traumatic optic neuropathy (TON) often show limited improvement in visual function despite therapy.Objective: This study aims to investigate whether targeted shortwave diathermy (SWD) combined with perceptual training enhances visual function in patients with severe TON following endoscopic optic nerve decompression (EOND) surgery.Methods: Forty patients with severe TON after EOND surgery were randomly assigned to either the rehabilitation (Reh) group (n = 24) or the non-rehabilitation (Nreh) group (n = 16). Subjects in the Reh group received targeted SWD therapy and perceptual training. Visual function, visual evoked potentials, and diffusion tensor imaging were evaluated.Results: After 16 weeks of rehabilitation, the best-corrected visual acuity (p = 0.006) and color vision scores (p = 0.026) in the Reh group improved significantly more than those in the Nreh group. Two children who had completely lost their visual acuity 62 and 73 days after experiencing TON regained visual acuity scores of 1.0 logMAR or lower after rehabilitation. After 10 weeks of rehabilitation, the mean P100 amplitude (p = 0.012) and fractional anisotropy (anterior segment, p = 0.032; middle segment, p = 0.014) of the affected nerves in the Reh group were significantly higher than those in the Nreh group.Conclusions: Targeted SWD combined with perceptual training demonstrated beneficial effects in patients with severe TON after EOND surgery. Notably, this study provides the first evidence of visual function recovery occurring 73 days after complete vision loss in child with TON when combined rehabilitation was implemented.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251319574"},"PeriodicalIF":1.4,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proliferative retinopathy in a patient with mutation in the CLCN2 gene. CLCN2基因突变患者的增殖性视网膜病变。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-02-21 DOI: 10.1177/11206721251316612

Waseem Nasser, Hadas Pizem, Yonatan Butbul Aviel, Tova Hershkovitz, Galit Tal, Shiri Zayit-Soudry, Efrat Naaman

{"title":"Proliferative retinopathy in a patient with mutation in the CLCN2 gene.","authors":"Waseem Nasser, Hadas Pizem, Yonatan Butbul Aviel, Tova Hershkovitz, Galit Tal, Shiri Zayit-Soudry, Efrat Naaman","doi":"10.1177/11206721251316612","DOIUrl":"https://doi.org/10.1177/11206721251316612","url":null,"abstract":"Purpose: CLCN2 is a gene that encodes the voltage-gated chloride channel protein 2 in the human brain and eyes. While mutations in this gene have been associated with leukoencephalopathy as well as ocular manifestations including optic neuropathy and choroidopathy, here we report for the first time a case of severe proliferative retinopathy in a patient with CLCN2 mutation.Observations: A 12-year-old girl with Familial Mediterranean Fever (FMF) was referred due to blurred vision in both eyes. Ophthalmoscopic examination revealed mild vitreous hemorrhage, large neovascularization at the disc (NVD), extensive neovascularization along the arcades (i.e., NVE; neovascularization elsewhere), retinal arteriolar narrowing, silver sheathing of the veins and preretinal hemorrhages. Fluorescein angiography (FA) demonstrated prominent leakage from multiple large NVEs. A thorough and multidisciplinary evaluation ruled out metabolic, thrombotic, infectious, inflammatory, or autoimmune etiologies. Notably, however, brain magnetic resonance imaging (MRI) revealed leukodystrophy yet poorly correlated with her clinical manifestation. Strikingly, whole exome sequencing uncovered a homozygous mutation in the CLCN2 gene. She was treated with intravitreal injections of the anti-vascular endothelial growth factor (VEGF) antibody Bevacizumab and laser pan-retinal photocoagulation (PRP) with partial response.Conclusions: This case suggests that CLCN2 mutation may possess a key role in an aggressive form of proliferative retinopathy with partial response to anti-VEGF therapy. We hypothesize that the potential underlying mechanism involves astrocyte dysfunction and retinal blood barrier disruption. Noteworthy, a comprehensive approach is unequivocally significant in evaluating such cases of proliferative retinopathy with unclear etiology to establish a diagnosis and management strategy.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251316612"},"PeriodicalIF":1.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term effect of repeated low-level red light therapy on myopia control: A systematic review and meta-analysis. 反复低强度红光治疗对近视控制的长期影响：系统回顾和荟萃分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-02-21 DOI: 10.1177/11206721251314541

Saif Ullah, Muhammad Farooq Umer, Suriyakala Perumal Chandran

{"title":"Long-term effect of repeated low-level red light therapy on myopia control: A systematic review and meta-analysis.","authors":"Saif Ullah, Muhammad Farooq Umer, Suriyakala Perumal Chandran","doi":"10.1177/11206721251314541","DOIUrl":"https://doi.org/10.1177/11206721251314541","url":null,"abstract":"Introduction: Myopia is a refractive error where distant objects are not clearly seen and appear blurred. Goal of this study was to evaluate long-term effectiveness of Repeated Low-Level Red Light (RLRL) therapy for children with myopia, which primarily focused on Axial length (AL) and Spherical Equivalent Refraction (SER) as primary endpoints.Methods: The research compared outcomes between RLRL treatment with Single Vision Spectacles (SVS) for childhood myopia management. We performed a systematic literature search in the PubMed, Embase and Cochrane databases using \"Myopia\" and \" Repeated Low-Level Red Light \". Mean differences (MD) were estimated and the effects of therapies measured. Publication bias and heterogeneity analysis were carried out by Inverted Precision Effect Test-Precision Effect Estimate Standard Error (PET-PEESE) (and subsequent Search Sequential Analysis) and Tau test. Bayesian meta-analysis was performed using Jaffrey Amazing Statistical Package (JASP).Results: This meta-analysis comprised 1,714 participants: 824 in RLRL and 890 in SVS group. Pooled effect size for AL reduction was 0.953 ± 0.294, (95% credible interval (CI) 0.775 to 0.980). Pooled effect size for SER reduction was 1.521 ± 0.662 (95% CI 0.102 to 2.736). PET-PEESE analysis revealed no significant publication bias (p-value 0.407). Random effects models were employed for presence of significant heterogeneity (3.9 and 5.7 for AL; 5.7 for SER), alongside degree of variation (0.828 & 1.665) for Tau (τ), which estimates the between-study variance.Conclusion: Long-term observations indicate that RLRL treatment significantly influences myopia management, leading to considerable reductions in both AL and SER. Additional research is essential to investigate potential long-term rebound effects.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251314541"},"PeriodicalIF":1.4,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0