European Journal of Ophthalmology最新文献_第9页

A case of progressive and irreversible visual loss as a consequence of delayed diagnosis in cerebrospinal fluid venous fistula. 脑脊液静脉瘘延迟诊断导致进行性和不可逆视力丧失1例。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-03-13 DOI: 10.1177/11206721251321880

Lucio Zeppa, Maria Laura Passaro, Amedeo Guida, Fabio Tortora, Carlo Petruzziello, Michele Rinaldi, Ciro Costagliola

{"title":"A case of progressive and irreversible visual loss as a consequence of delayed diagnosis in cerebrospinal fluid venous fistula.","authors":"Lucio Zeppa, Maria Laura Passaro, Amedeo Guida, Fabio Tortora, Carlo Petruzziello, Michele Rinaldi, Ciro Costagliola","doi":"10.1177/11206721251321880","DOIUrl":"10.1177/11206721251321880","url":null,"abstract":"PurposeCerebrospinal fluid venous fistulas (CVFs) are a frequently underrecognized cause of cerebrospinal fluid (CSF) leaks, leading to intracranial hypotension and a wide range of symptoms, including visual disturbances. This case highlights the critical role of ophthalmologists in identifying CVFs as a cause of unexplained progressive vision loss.MethodsWe present the case of a 45-year-old woman who developed progressive visual field loss over 15 years, ultimately resulting in blindness in one eye. Early neuroimaging and testing were normal despite symptoms of orthostatic headaches, photophobia, and hearing loss. Advanced imaging eventually identified a CVF at the T8 level. Surgical correction was performed, and the patient's clinical response was assessed.ResultsSurgical repair of the CVF led to clinical improvement, halting further progression of symptoms.ConclusionsCVFs should be considered in patients with unexplained visual disturbances, particularly when accompanied by symptoms of intracranial hypotension. Early suspicion and collaboration with neurologists and neuroradiologists are essential for timely diagnosis and intervention. Ophthalmologists play a pivotal role in guiding appropriate referrals, ensuring multidisciplinary care to prevent irreversible visual and systemic complications.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP32-NP37"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-supine versus supine position after endothelial keratoplasty: A systematic review and meta-analysis. 内皮角膜移植术后非仰卧位与仰卧位：一项系统回顾和荟萃分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 DOI: 10.1177/11206721251372379

Lily Silva Ardiani, Aknes Sintiya Dewi, Johan Arif Hutauruk, Sharita Rosalyne Siregar

{"title":"Non-supine versus supine position after endothelial keratoplasty: A systematic review and meta-analysis.","authors":"Lily Silva Ardiani, Aknes Sintiya Dewi, Johan Arif Hutauruk, Sharita Rosalyne Siregar","doi":"10.1177/11206721251372379","DOIUrl":"https://doi.org/10.1177/11206721251372379","url":null,"abstract":"There are some disputes regarding the necessity of maintaining a supine position after endothelial keratoplasty (EK) to ensure graft attachment. We aimed to evaluate the efficacy of a supine position after EK in reducing the risk of postoperative graft detachment. This systematic review with meta-analysis was registered in PROSPERO under protocol CRD42024541226. PubMed, Scopus, Embase, and Cochrane Central Register of Controlled Trials databases were systematically searched for studies comparing non-supine versus supine positions after EK. We pooled risk ratios (RR) and 95% confidence intervals (CI) for dichotomous outcomes and mean differences (MD) with 95% CI for continuous outcomes using a random-effects model. We included two randomized controlled trials and two observational studies comprising 456 eyes, of which 173 (37.9%) were assigned to non-supine positions. There were no significant differences in the incidence of graft detachment (RR 1.09; 95% CI 0.52-2.26; p = 0.82), rebubbling rate (RR 1.05; 95% CI 0.46-2.41; p = 0.90) and need for repeat keratoplasty (RR 2.37; 95% CI 0.13-41.99; p = 0.56) between non-supine and supine groups. There was also no difference in visual acuity (MD -0.02 LogMAR; 95% CI -0.11-0.08; p = 0.75) and intraocular pressure (MD -1.44 mmHg; 95% CI -8.49-5.61; p = 0.69) between groups. Subgroup analysis of DMEK (RR 0.73; 95% CI 0.38-1.42; p = 0.35) and DSAEK (RR 1.96; 95% CI 0.95-4.04; p = 0.07) also showed no difference in graft detachment between groups. Maintaining a supine position after EK surgery did not significantly affect graft detachment, rebubbling rate, need for repeat keratoplasty, visual acuity, or intraocular pressure.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251372379"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customized treatment for myopic traction maculopathy based on the MTM staging system: Long-term results in naïve eyes. 基于MTM分期系统的近视牵引性黄斑病变的定制治疗：naïve眼睛的长期结果。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-21 DOI: 10.1177/11206721251335390

Barbara Parolini, Veronika Matello, Michele Palmieri, Radina Kirkova, Matteo Ripa

{"title":"Customized treatment for myopic traction maculopathy based on the MTM staging system: Long-term results in naïve eyes.","authors":"Barbara Parolini, Veronika Matello, Michele Palmieri, Radina Kirkova, Matteo Ripa","doi":"10.1177/11206721251335390","DOIUrl":"10.1177/11206721251335390","url":null,"abstract":"PurposeTo explore the long-term anatomical and functional outcomes in naïve patients with Myopic Traction Maculopathy (MTM) treated with either macular buckle (MB) plus pars plana vitrectomy (PPV) or primary MB as unique treatment according to MTM Staging System (MSS).MethodsRetrospective study involving 206 consecutive naïve patients with MTM who underwent either MB plus PPV or primary MB. Postoperative anatomical and functional outcomes, including the MTM stage and its progression, axial length (AL), and best-corrected visual acuity (BCVA) changes, were evaluated at one month (i.e., \"early follow-up\"), six months (i.e., intermediate follow-up\"), 12 months postoperatively (i.e., \"late follow-up\") and at last follow-up ranging between 12 and 156 months postoperatively (i.e., \"final follow-up\").ResultsRetinal and foveal anatomical results significantly improved in patients who underwent either primary MB plus PPV or MB (p < 0.001), with 100% and 92.1% of patients who underwent complete resolution, respectively. For every MTM stage, the BCVA significantly improved over the follow-up visits. (p < 0.001). At the last visit, 84 (41%) eyes improved to 0.5 decimal or more. In patients treated before 2020, when applying more combined PPV treatments, there was a high rate of early iatrogenic full-thickness macular holes (p = 0.005). The results obtained since 2020, when the customized treatment was employed, led to better results without sight-threatening complications.ConclusionsThe MTM Staging System should be the foundation for treating MTM. It should precisely assess the optimal surgical technique and the ideal time to perform it concerning the various stages to maximize anatomical and functional success.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1842-1853"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol delamination and topical mitomycin-C 0.02% for the treatment of corneal intraepithelial neoplasia. 酒精分层和外用0.02%丝裂霉素c治疗角膜上皮内瘤变。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-06 DOI: 10.1177/11206721251340235

Marco Messina, Davide Tucci, Maria Poddi, Luca Pagano, Carlo Cagini

{"title":"Alcohol delamination and topical mitomycin-C 0.02% for the treatment of corneal intraepithelial neoplasia.","authors":"Marco Messina, Davide Tucci, Maria Poddi, Luca Pagano, Carlo Cagini","doi":"10.1177/11206721251340235","DOIUrl":"10.1177/11206721251340235","url":null,"abstract":"PurposeTo report a case of a patient diagnosed with corneal intraepithelial neoplasia (CIN) with ocular discomfort and blurred vision, successfully treated with alcohol delamination (ALD) and topical mitomycin-C.MethodsA 69 year-old man underwent a full slit lamp examination which revealed the presence of a superficial corneal lesion appearing as an opaque intraepithelial plaque extending from the limbus to the visual axis. A manifest refraction with a best corrected visual acuity (BCVA), an anterior segment OCT (AS-OCT) and a corneal topography were performed. In order to remove the lesion an ALD was carried out and the obtained tissue sample was sent for histopathological evaluation confirming the diagnosis of CIN. At the end of the procedure, a bandage contact lens was applied, and the eye was started on a topical treatment with Netilmicin 3% and Dexamethasone 1% 4 times daily for 15 days and mitomycin-C 0.02% drops four times a day, on alternate weeks for 4 weeks.ResultsPatient's symptoms improved and BCVA was restored to 20/20 over 1-month period. The ocular surface showed a significant regularization, clinically and both at the AS-OCT and corneal topography. Three years after the procedure patient's BCVA and refraction were stable without any sign of recurrence.ConclusionsALD is a safe and inexpensive procedure when dealing with CIN allowing both clinical improvements and a definitive histopathological diagnosis.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP5-NP7"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of treatment with faricimab for patients with refractory nAMD. 法利西单抗治疗难治性nAMD的疗效观察。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-03-26 DOI: 10.1177/11206721251328097

Nabila Jones, Christa Gore, Habiba Saedon, Clare O'Donnell, Sajjad Mahmood

{"title":"Efficacy of treatment with faricimab for patients with refractory nAMD.","authors":"Nabila Jones, Christa Gore, Habiba Saedon, Clare O'Donnell, Sajjad Mahmood","doi":"10.1177/11206721251328097","DOIUrl":"10.1177/11206721251328097","url":null,"abstract":"ObjectiveTo investigate the efficacy of treatment with faricimab in patients with refractory neovascular age-related macular degeneration (nAMD).MethodsA Single-centre, retrospective cohort study was conducted on patients treated with faricimab for refractory nAMD. Outcome measures comprised best measured visual acuity (BMVA), central foveal thickness (CFT) on optical coherence tomography (OCT) and mean treatment interval for patients receiving six or more faricimab injections.ResultsCFT was shown to significantly decrease for all eyes (N = 52) treated with six faricimab injections (χ 52.88 df 5 p < 0.001) from baseline (274 ± 73 µm) and subsequent injections (244 ± 59 µm). BMVA remained stable (χ 6.45 df 5 p = 0.26) from baseline treatment (baseline, 67 letters ± 13) and subsequent injections with faricimab (67 letters ± 14, injection 6). Mean treatment interval with faricimab increased from 4.2 weeks to 5.8 weeks indicating sustained results. Zero cases of post-operative complications were reported.ConclusionThis study adds to the growing body of real-world evidence supporting the efficacy of faricimab in treating refractory nAMD. With improvements in anatomical outcomes and an extended treatment interval, whilst maintaining stable vision, faricimab emerges as a promising therapeutic option for patients with refractory nAMD.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1695-1702"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment of AMD-related macular neovascularization in a patient with silicone oil tamponade. 硅油填塞患者amd相关性黄斑新生血管的治疗。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-18 DOI: 10.1177/11206721251333273

Guglielmo Parisi, Francesco Gelormini, Veronica Vallino, Federico Ricardi, Paola Marolo, Enrico Borrelli, Ugo De Sanctis, Michele Reibaldi

{"title":"Treatment of AMD-related macular neovascularization in a patient with silicone oil tamponade.","authors":"Guglielmo Parisi, Francesco Gelormini, Veronica Vallino, Federico Ricardi, Paola Marolo, Enrico Borrelli, Ugo De Sanctis, Michele Reibaldi","doi":"10.1177/11206721251333273","DOIUrl":"10.1177/11206721251333273","url":null,"abstract":"Purpose: to present a case of active neovascular AMD treated with anti-VEGF drug in the presence of silicone oil. Study design: case report. Results: A 69-year-old male was referred to the surgical retina service due to a sudden loss of peripheral vision in the left eye (LE). Biomicroscopic examination revealed the presence of geographic atrophy in the right eye (RE) and a macula-on retinal detachment in the far periphery with drusen at the posterior pole in LE. Combined OCT-OCTA examination demonstrated the presence of non-active type 1 MNV in the LE. The patient underwent a 25-gauge pars plana vitrectomy (PPV) with silicone oil tamponade in the LE. Post-operative follow-up involved clinical and instrumental monitoring every 7 days for the first 3 months and every 15 days in the fourth month, until the removal of the silicone oil. During the follow-up, we detected the reactivation of type 1 MNV in the LE, and as a result, the patient received three monthly Ranibizumab injections in the LE, in conjunction with the removal of silicone oil from the vitreous cavity at the at the fourth month postoperatively. Conclusions: our case report highlights the clinical response to three injections of intravitreal Ranibizumab therapy in managing active neovascular AMD with SO tamponade. The duration of intravitreal Ranibizumab therapy in SO may not differ significantly compared to an eye with intact vitreous humor.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP59-NP63"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical characteristics and outcomes of primary orbital lymphoma. 原发性眼眶淋巴瘤的临床特点及预后。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-29 DOI: 10.1177/11206721251338705

Kenny Y Wang, B Michelle Kim, Caroline Y Yu, Grant M Welk, Robert A Churchill, Launia J White, David O Hodge, Lauren A Dalvin, Andrea A Tooley

{"title":"Clinical characteristics and outcomes of primary orbital lymphoma.","authors":"Kenny Y Wang, B Michelle Kim, Caroline Y Yu, Grant M Welk, Robert A Churchill, Launia J White, David O Hodge, Lauren A Dalvin, Andrea A Tooley","doi":"10.1177/11206721251338705","DOIUrl":"10.1177/11206721251338705","url":null,"abstract":"PurposeTo describe the clinical characteristics, histopathologic subtype distribution, treatment, and outcomes of patients with primary orbital lymphoma.Major FindingsThere were 126 biopsy-confirmed cases of primary orbital lymphoma, with 81 (64.3%) female and 110 (87.3%) white. The average age at diagnosis was 62.7 ± 13.9 years. There were 26 (20.6%) cases with bilateral involvement. The most frequent lymphoma subtype was MALT lymphoma (N = 76, 60.3%), followed by diffuse large B-cell lymphoma (N = 18, 14.3%) and follicular lymphoma (N = 12, 9.5%). Prognosis was generally favorable, as local recurrence occurred in only 14 (11.1%) patients and final best corrected visual acuity (BCVA) loss of >1 line was seen in 30 (28.0%) patients. Bilateral lymphoma and advanced stage (Ann Arbor Stage III or IV) at presentation were associated with increased risk of local recurrence (p = 0.0025, p = 0.049). Improved disease-specific survival was associated with diagnosis at Stage I or II (p = 0.013), MALT subtype (p = 0.034), or lack of chemotherapy requirement as primary treatment (p = 0.0073).ConclusionsIn this single center academic cohort, MALT lymphoma subtype was most common. Overall orbital recurrence frequency was low, and bilateral lymphoma and advanced stage were associated with increased risk of local recurrence. MALT lymphoma subtype was associated with improved disease-specific survival. Long-term follow-up showed that most patients retained good visual acuity in the affected eye(s).","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1776-1785"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the retinal segmentation analysis in patients with clinically unilateral pseudoexfoliation syndrome. 临床单侧假性脱落综合征患者视网膜分割分析的比较。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-17 DOI: 10.1177/11206721251334163

Serkan Akkaya, Umay Güvenç, Ayşe Balıkçı, Gülizar Demirok, Güner Özkan, Selma Uzman, Naci Ertürk, Ayşe Burcu

{"title":"Comparison of the retinal segmentation analysis in patients with clinically unilateral pseudoexfoliation syndrome.","authors":"Serkan Akkaya, Umay Güvenç, Ayşe Balıkçı, Gülizar Demirok, Güner Özkan, Selma Uzman, Naci Ertürk, Ayşe Burcu","doi":"10.1177/11206721251334163","DOIUrl":"10.1177/11206721251334163","url":null,"abstract":"PurposeTo compare the thicknesses of each retinal layer in patients with clinically unilateral pseudoexfoliation syndrome (XFS) versus unaffected fellow eyes and healthy age-matched controls.MethodsIn this cross-sectional study, a complete ophthalmologic evaluation, including intraocular pressure (IOP) measurement, was performed in 40 patients with unilateral XFS-affected and 43 healthy controls. After confirming that fellow eyes were clinically unaffected, all eyes underwent the retinal layer segmentation analysis using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). The thickness maps were divided into nine subfields (i.e., 1-mm, 3-mm, and 6-mm grids) using the Early Treatment Diabetic Retinopathy Study (ETDRS) and were extracted from the software to compare the groups.ResultsIn the 1-mm central subfield, thicknesses of the ganglion cell layer (GCL), inner plexiform layer (IPL), and inner retinal layer (IRL) were significantly reduced both in XFS-affected and fellow eyes than in controls. Additionally, the thicknesses of the inner nuclear layer (INL) and outer plexiform layer (OPL) were significantly reduced in fellow eyes compared to controls. Comparison of XFS-affected versus fellow eyes in the 1-mm central subfield showed no significant differences in GCL, IPL, IRL, INL, and OPL thicknesses (p > 0.05, for all; Tukey HSD test). In ETDRS subfields, 3-mm temporal and 3-mm inferior IPL thicknesses of fellow eyes and 6-mm temporal INL thickness in XFS-affected eyes were reduced compared to controls (p < 0.05, for all).ConclusionIn clinically unilateral XFS, the consequential thinning of retinal layers in the fellow eye accompanies the significant thinning of retinal layers in the affected eye.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1637-1646"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are blood platelet parameters associated with retinal nerve fiber layer thickness Among healthy young adults? a university-based study. 健康年轻人血小板参数与视网膜神经纤维层厚度有关吗？以大学为基础的研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-21 DOI: 10.1177/11206721251335375

Dan-Lin Li, Min-Xin Liu, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Ya-Jie Zheng, Yu Qin, Gang Liang, Chen-Wei Pan

{"title":"Are blood platelet parameters associated with retinal nerve fiber layer thickness Among healthy young adults? a university-based study.","authors":"Dan-Lin Li, Min-Xin Liu, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Ya-Jie Zheng, Yu Qin, Gang Liang, Chen-Wei Pan","doi":"10.1177/11206721251335375","DOIUrl":"10.1177/11206721251335375","url":null,"abstract":"BackgroundPlatelet parameters have been linked with glaucomatous optic neuropathy but whether they were associated with retinal nerve fiber layer (RNFL) thickness among healthy individuals remains unclear. We aim to determine the relationship between different platelet parameters and RNFL thickness in healthy university students.MethodsThe Dali University Students Eye Health Study is a university-based, cross-sectional study in southwestern China in 2021. RNFL thickness was measured automatically using an optical coherence tomography scanner. An automated hematology analyzer was used to analyze the platelet parameters including platelet (PLT) count, platelet distribution width (PDW), mean platelet volume (MPV) and plateletcrit (PCT). Linear regression models and generalized additive models were established to examine the associations of platelet parameters with RNFL thickness.ResultsA total of 1905 participants with valid RNFL thickness and platelet parameters data were included in the current analysis. Per unit increase in the levels of MPV and PDW was associated with a decrease of 0.74 μm (P = 0.04) and 0.35 μm (P = 0.04) in RNFL thickness in multivariable-adjusted model. Subgroup analyses indicated that the association between MPV and RNFL thickness was present in male students. A non-linear trend in the association of MPV with RNFL thickness were observed (P = 0.04).ConclusionIncreased levels of MPV and PDW were associated with thinner RNFLs among university students, suggesting that the platelet parameters, a simple, global, and economical markers, have the potentials to be an additional valuable biomarker for predicting the change of RNFL thickness and onset of RNFL-related nerve diseases in late adulthood.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1767-1775"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing accuracy, readability & reliability of AI-generated patient leaflets on Descemet membrane endothelial keratoplasty. 评估人工智能生成的网膜内皮角膜移植术患者小叶的准确性、可读性和可靠性。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-28 DOI: 10.1177/11206721251367562

Bnar Massraf, Ka Kiu Cheris Chan, Nikhil Jain, Jesse Panthagani

{"title":"Assessing accuracy, readability & reliability of AI-generated patient leaflets on Descemet membrane endothelial keratoplasty.","authors":"Bnar Massraf, Ka Kiu Cheris Chan, Nikhil Jain, Jesse Panthagani","doi":"10.1177/11206721251367562","DOIUrl":"https://doi.org/10.1177/11206721251367562","url":null,"abstract":"PurposeThis study assessed the readability, reliability and accuracy of patient information leaflets on Descemet Membrane Endothelial Keratoplasty (DMEK), generated by seven large language models (LLMs). The aim was to determine which LLM produced the most patient-friendly, comprehensible and evidence-based leaflet, measured against a leaflet written by clinicians from a tertiary centre.MethodsEach LLM was given the prompt, \"Make a patient information leaflet on Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.\" Readability metrics (FKG, FRE, ARI, Gunning Fog), reliability metrics (DISCERN, PEMAT), misinformation detection and reference analysis were recorded for each response. A weighted scoring system normalised results on a 0-100% scale.ResultsThe clinician-generated leaflet scored the highest (92%). Claude 3.7 Sonnet had the top LLM score (77.8%), with strong readability and referencing. ChatGPT-4o followed closely (70.9%) but lacked references. Moderate scores for DeepSeek-V3, Perplexity AI and Google Gemini 2.0 Flash. ChatGPT-4 and Microsoft CoPilot scored the lowest due to limited reliability and misinformation.ConclusionsLLMs show promise in generating patient education material but vary in reliability and accuracy. Claude 3.7 Sonnet was the best performing LLM, though none matched in quality to the clinician-generated leaflet. LLM-generated leaflets therefore require clinician oversight before safe clinical use.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251367562"},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0