European Journal of Ophthalmology最新文献

Visual and anatomical outcomes of early versus delayed anti-VEGF switching after bevacizumab loading in diabetic macular oedema. 糖尿病黄斑水肿患者贝伐单抗负荷后早期与延迟抗vegf转换的视觉和解剖学结果

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-19 DOI: 10.1177/11206721261499885

Rukiye Kilic Ucgul, Kemal Tekin, Dogukan Temel, Furkan Karagoz, Busra Turpcuoglu, Merve Inanc Tekin, Kuddusi Teberik

{"title":"Visual and anatomical outcomes of early versus delayed anti-VEGF switching after bevacizumab loading in diabetic macular oedema.","authors":"Rukiye Kilic Ucgul, Kemal Tekin, Dogukan Temel, Furkan Karagoz, Busra Turpcuoglu, Merve Inanc Tekin, Kuddusi Teberik","doi":"10.1177/11206721261499885","DOIUrl":"https://doi.org/10.1177/11206721261499885","url":null,"abstract":"PurposeTo compare 24-month visual and anatomical outcomes associated with early versus delayed switching from bevacizumab in treatment-naive eyes with center-involving diabetic macular edema (DME) and suboptimal early response.MethodsThis retrospective cohort included 87 eyes with inadequate response (<5 ETDRS-letter gain and/or <20% central macular thickness [CMT] reduction) after three monthly bevacizumab injections. In a month-3 landmark analysis, eyes were classified by the month-3 treatment decision as immediate switch (n = 37) or continued bevacizumab with later switching (n = 50). An observed-timing comparison excluded eyes switched at months 4-5 (n = 7) and compared early switch (month 3; n = 37) with delayed switch (month ≥6; n = 43) to aflibercept 2 mg or ranibizumab. Outcomes from the month-3 decision point were evaluated using adjusted mixed-effects models with categorical time.ResultsAt month 3, BCVA (0.42 versus 0.45 logMAR) and CMT (437 versus 408 µm) were similar in the early- and delayed-switch groups. In the landmark analysis, adjusted 24-month differences were -0.07 logMAR (95% CI, -0.17 to 0.03; P = 0.171), equivalent to 3.5 ETDRS letters favoring immediate switching (95% CI, -1.5 to 8.5), and -36 µm (95% CI, -71 to -1; P = 0.044). In the observed-timing comparison, they were -0.08 logMAR (4.0 letters; 95% CI, -1.5 to 9.5; P = 0.154) and -39 µm (95% CI, -77 to -1; P = 0.044). A ≥ 20% CMT reduction at month 24 occurred in 62.2% versus 37.2%. Total injections numbered 11.2 ± 2.4 versus 14.5 ± 2.6.ConclusionsEarlier switching was associated with greater anatomical improvement in both analyses. A 24-month visual advantage was not demonstrated, although a clinically meaningful benefit could not be excluded.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261499885"},"PeriodicalIF":1.3,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on: "Optimizing topical glaucoma treatment outcomes: When less is better. A review on the clinical benefits of reducing treatment burden in glaucoma management". 评论：“优化局部青光眼治疗效果：越少越好。减轻青光眼治疗负担的临床获益综述。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-16 DOI: 10.1177/11206721261473757

Louis Arnould

引用次数: 0

Adult presentation of a congenital zonular cataract. 成人一例先天性带状白内障。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-14 DOI: 10.1177/11206721261499882

Aayush Majumdar, Vibha Dhiman

引用次数: 0

Pretreatment MRI radiomics for predicting recurrence and metastasis after hypofractionated stereotactic radiosurgery in uveal melanoma. 预处理MRI放射组学预测葡萄膜黑色素瘤低分割立体定向放射手术后复发和转移。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-12 DOI: 10.1177/11206721261495745

Yusuf Baytar, Firat Atak, Gozde Yazici, Irem Koc, Hayyam Kiratli, Elif Gunay Bulut

{"title":"Pretreatment MRI radiomics for predicting recurrence and metastasis after hypofractionated stereotactic radiosurgery in uveal melanoma.","authors":"Yusuf Baytar, Firat Atak, Gozde Yazici, Irem Koc, Hayyam Kiratli, Elif Gunay Bulut","doi":"10.1177/11206721261495745","DOIUrl":"https://doi.org/10.1177/11206721261495745","url":null,"abstract":"PurposeTo develop and internally evaluate pretreatment MR-based radiomics models for predicting local recurrence and metastasis after hypofractionated stereotactic radiosurgery (SRS) for uveal melanoma.MethodsThis retrospective study analyzed pretreatment MRI (T1-weighted, T2-weighted, contrast-enhanced T1-weighted) of 88 SRS-treated UM patients. Tumors were segmented on the axial slice with the greatest cross-sectional area, and 854 radiomic features were extracted for each sequence. After inter-observer reproducibility filtering (ICC ≥ 0.80) and elastic-net feature selection, separate Gaussian Naive Bayes models for local recurrence and metastasis were developed using the retained features with a 70:30 train-test split. SMOTE was applied within training folds to address class imbalance. Held-out test set performance was assessed using AUC, F1 score, accuracy, sensitivity, specificity, and predictive values.ResultsThe local-recurrence model achieved an AUC of 0.958, accuracy of 0.889, sensitivity of 1.00 (3/3), and specificity of 0.875 (21/24). The metastasis model showed limited discrimination (AUC, 0.528; accuracy, 0.815; sensitivity, 0.333 [1/3]; specificity, 0.875 [21/24]). Among three-fraction treatments, a total dose >45 Gy was associated with less local recurrence (p = 0.010), whereas no other clinical variable was significantly associated with either outcome.ConclusionMRI radiomics showed promising discrimination for local recurrence but limited discrimination for metastasis. These findings should be interpreted with caution given the small number of events in the test set and warrant external validation in larger cohorts.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261495745"},"PeriodicalIF":1.3,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of ocular surface squamous neoplasia in clinically diagnosed pterygium specimens: A systematic review and meta-analysis. 临床诊断的翼状胬肉标本中眼表鳞状瘤变的患病率：系统回顾和荟萃分析。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-09 DOI: 10.1177/11206721261496343

Elaheh Foroughi, Mahsa Pourmahdi-Boroujeni, Samira Chaibakhsh, Aida Ghasvarian, Amirhossein Zivdari, Sadegh Ghafarian, Alireza Peyman, Mohsen Pourazizi

{"title":"Prevalence of ocular surface squamous neoplasia in clinically diagnosed pterygium specimens: A systematic review and meta-analysis.","authors":"Elaheh Foroughi, Mahsa Pourmahdi-Boroujeni, Samira Chaibakhsh, Aida Ghasvarian, Amirhossein Zivdari, Sadegh Ghafarian, Alireza Peyman, Mohsen Pourazizi","doi":"10.1177/11206721261496343","DOIUrl":"https://doi.org/10.1177/11206721261496343","url":null,"abstract":"The purpose of the article was to determine the pooled prevalence of co-existing ocular surface squamous neoplasia (OSSN) among clinically diagnosed pterygium (PTG) specimens.A systematic review and meta-analysis were conducted using online databases to identify relevant articles up to May 2024. Eligible original studies that reported the prevalence of non-PTG and co-existing OSSN in clinically diagnosed PTG cases that underwent surgical excision and histopathological evaluation were included. Additionally, based on the geographical coordinates (latitude and longitude) of each study and the global skin pigmentation map, skin types were defined and included. A total of 21 cross-sectional studies consisting of 23,165 specimens from 22,921 patients were included. The pooled prevalence of non-PTG and co-existing OSSN diagnoses after excluding outlier results was 3.8% (95% CI: 1.9-5.8) and 3.7% (95% CI: 1.8-5.7), respectively. Studies from countries with predominantly medium skin pigmentation showed a significantly higher prevalence of co-existing OSSN (10.25% [95% CI: 8.1-12.45, P < 0.001]) compared to those from countries with predominantly white (2.45% [95% CI: 0.0-5.2, P = 0.008] or brown (3.1% [95% CI: 0.65-5.5, P = 0.01]) skin types. A positive association was also observed between regional altitude and co-existing OSSN prevalence (regression coefficient = 0.005, P < 0.001). In conclusion, pathological assessment of PTG specimens may be considered to avoid misdiagnosis and ensure appropriate management.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261496343"},"PeriodicalIF":1.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal ophthalmic findings in patients with mucopolysaccharidosis: A prospective observational study. 粘多糖病患者的多模态眼科表现：一项前瞻性观察研究。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-09 DOI: 10.1177/11206721261496330

Esra Biberoğlu Çelik, Emine Genç, Emel Yılmaz Gümüş, Sebile Kılavuz, Burcu Öztürk Hişmi, Semra Akkaya Turhan, Özlem Şahin

{"title":"Multimodal ophthalmic findings in patients with mucopolysaccharidosis: A prospective observational study.","authors":"Esra Biberoğlu Çelik, Emine Genç, Emel Yılmaz Gümüş, Sebile Kılavuz, Burcu Öztürk Hişmi, Semra Akkaya Turhan, Özlem Şahin","doi":"10.1177/11206721261496330","DOIUrl":"https://doi.org/10.1177/11206721261496330","url":null,"abstract":"PurposeTo characterize ocular involvement in pediatric patients with mucopolysaccharidosis (MPS) using multimodal assessment, with emphasis on corneal densitometry and visual electrophysiology.MethodsThis prospective observational study included 22 patients with molecularly confirmed MPS. Ophthalmic assessment comprised best-corrected visual acuity, cycloplegic refraction, intraocular pressure, ultrasound pachymetry, slit-lamp grading of corneal opacity, Scheimpflug densitometry, in vivo corneal confocal microscopy, optical coherence tomography (OCT), and B-scan ultrasonography. Full-field electroretinography (FF-ERG) and flash visual evoked potentials (Flash VEP) were performed in cooperative patients.ResultsMean age was 9.05 ± 3.46 years, and 11 patients (50.0%) had MPS VI. Corneal opacity was present in 20 patients: mild in nine, moderate in eight, and severe in three. Mean corneal densitometry was 30.1 ± 10.9 grayscale units in the right eye and 28.5 ± 9.1 in the left eye. Densitometry values correlated strongly with corneal opacity grade (right: rs = 0.858, p < 0.001; left: rs = 0.696, p = 0.006). Corneal opacity precluded fundus examination in 11 patients; B-scan ultrasonography showed no posterior segment abnormality. OCT was evaluable in 15 patients and showed preserved macular morphology. Elevated intraocular pressure requiring treatment occurred in four patients with MPS VI; one also had bilateral optic atrophy. FF-ERG abnormalities were identified in nine of 14 tested patients, and bilateral flash VEP P2 latency prolongation was reported in four.ConclusionCorneal opacity was the predominant ocular manifestation and frequently limited posterior segment assessment. Multimodal structural and functional testing provided complementary information on corneal, glaucoma-related, optic nerve, and retinal involvement in MPS.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261496330"},"PeriodicalIF":1.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microsurgical two-wall orbital decompression for treatment of visual impairment in patients with thyroid-associated ophthalmopathy. 显微外科双壁眶减压术治疗甲状腺相关性眼病视力损害。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-09 DOI: 10.1177/11206721261496333

Tammam Abboud, Maren Horn, Michael Schittkowski, Veit Rohde

{"title":"Microsurgical two-wall orbital decompression for treatment of visual impairment in patients with thyroid-associated ophthalmopathy.","authors":"Tammam Abboud, Maren Horn, Michael Schittkowski, Veit Rohde","doi":"10.1177/11206721261496333","DOIUrl":"https://doi.org/10.1177/11206721261496333","url":null,"abstract":"BackgroundDysthyroid optic neuropathy (DON) is a vision-threatening complication of thyroid-associated ophthalmopathy that may require urgent surgical intervention. We describe a microsurgical two-wall orbital decompression technique designed to achieve effective orbital and optic nerve decompression in extremely severe cases as an additional option.MethodsA frontotemporal extradural approach is used to remove the lateral orbital wall and orbital roof, with optional decompression of the optic canal. Neuronavigation guides bone removal and helps avoid violation of the frontal sinus. The surgical technique, anatomical landmarks, and perioperative considerations are described in detail, and key steps are demonstrated in an accompanying video.ResultsTwelve orbits in 7 patients (mean age 60 ± 5 years) underwent microsurgical two-wall orbital decompression for treatment of visual impairment due to DON. The technique allows controlled removal of the lateral orbital wall and orbital roof with excellent visualization of the orbit and optic canal. Adequate orbital volume expansion and optic nerve decompression can be achieved while preserving critical anatomical structures. The procedure is associated with low technical morbidity.ConclusionMicrosurgical two-wall orbital decompression appears to be a clinically applicable and feasible technique for the treatment of visual impairment due to DON. It may be considered in selected patients with severe or refractory disease and persistent visual impairment despite prior decompression.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261496333"},"PeriodicalIF":1.3,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term evolution of macular fibrosis in neovascular age-related macular degeneration. 新生血管性年龄相关性黄斑变性中黄斑纤维化的长期演变。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-08 DOI: 10.1177/11206721261495050

Alicia Valverde Megías, Jose Ignacio Fernández-Vigo, Haizea Etxabe-Ávila, Antonio Alarcón García, Julián García-Feijoo

{"title":"Long-term evolution of macular fibrosis in neovascular age-related macular degeneration.","authors":"Alicia Valverde Megías, Jose Ignacio Fernández-Vigo, Haizea Etxabe-Ávila, Antonio Alarcón García, Julián García-Feijoo","doi":"10.1177/11206721261495050","DOIUrl":"https://doi.org/10.1177/11206721261495050","url":null,"abstract":"PurposeTo evaluate long-term tomographic findings in a series of neovascular age-related macular degeneration (nAMD) patients with macular fibrosis.MethodsBest corrected visual acuity (BCVA) and foveal 6-mm optical coherence tomography (OCT) of 30 eyes with stablished fibrosis due to nAMD were collected with a follow-up of five years. A reproducibility study was performed. Subfoveal retinal thickness (SRT), subfoveal fibrosis thickness (SFT), fibrosis extension and sectional area of the fibrosis in a single frame were recorded.ResultsMean age was 79.7 years (53% females). Bilateral fibrosis was present at baseline in 16% of patients rising to 63% at the end of study period. BCVA was 32.2 ETDRS letters in study eyes at baseline, decreased the second year and was stable at 22 letters for the following three years. Unaffected eyes remained with stable vision (70 ETDRS letters) at five years. Intraclass correlation coefficients were above 0.9 for all measurements. SFT was reduced the first three years and stabilized the last two years. SRT experienced progressive decrease without a plateau. Fibrosis longitudinal extension and sectional area remained unchanged during the five years.ConclusionsBCVA stabilizes from the third year on. Macular fibrosis experienced a limited compaction process with progressive neurosensory retinal thinning.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261495050"},"PeriodicalIF":1.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular immune-related adverse events with immune checkpoint inhibitors: A retrospective cohort study. 免疫检查点抑制剂的眼部免疫相关不良事件：一项回顾性队列研究。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-08 DOI: 10.1177/11206721261496326

Blake A Boehm, Haitham Sahawneh, Iris Yeong-Fung Sheng

{"title":"Ocular immune-related adverse events with immune checkpoint inhibitors: A retrospective cohort study.","authors":"Blake A Boehm, Haitham Sahawneh, Iris Yeong-Fung Sheng","doi":"10.1177/11206721261496326","DOIUrl":"https://doi.org/10.1177/11206721261496326","url":null,"abstract":"BackgroundImmune checkpoint inhibitors (ICIs) are widely used to treat a variety of malignancies. Ocular immune-related adverse events (irAEs) have been increasingly recognized as rare side effects of these medications.MethodsWe performed a retrospective study of ocular irAEs at our institution between 2017 and 2025. Ophthalmic and oncologic data were extracted, and visual acuity was compared before, during, and after events.ResultsNineteen ocular irAEs occurred in 17 patients. Melanoma and pembrolizumab were the most common type of malignancy and ICI, respectively. Most events were low grade (78.9%), with uveitis being the most common (36.8%). Ocular irAEs developed after a mean of 3.6 ± 3.2 cycles (155 ± 191 days) of ICI treatment. Best-corrected visual acuity (BCVA) declined significantly during events from 0.06 ± 0.12 logMAR (20/23) to 0.22 ± 0.30 logMAR (20/33) (p = 0.011). There was no significant difference between BCVA at baseline and after irAE treatment. Resolution of the ocular irAE occurred in 78.9% of patients.ConclusionsOcular events tended to occur soon after ICI initiation; however, time to onset varied. Most patients responded well to treatment and experienced resolution of the ocular event. ICI discontinuation may be necessary for severe ocular adverse events. Close collaboration between ophthalmologists and oncologists is essential when managing ocular irAEs.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261496326"},"PeriodicalIF":1.3,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The wandering lens: Clear Lens in the anterior chamber following blunt trauma. 游离晶状体：钝性外伤后前房晶状体清晰。

IF 1.3 4区医学

European Journal of Ophthalmology Pub Date : 2026-10-07 DOI: 10.1177/11206721261488972

Anjalika Parhi, Santosh Kumar Mahapatra, Rohit Chavan, Prachi Saraogi

引用次数: 0