European Journal of Ophthalmology最新文献

AI chatbots in strabismus care: A multidomain expert evaluation of caregiver-facing information. 人工智能聊天机器人在斜视护理中的应用：护理人员面向信息的多领域专家评估。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-06 DOI: 10.1177/11206721261445529

Dhiman Shweta, Dutta Paromita, Thacker Prolima, Kaur Savleen, Maniar Ashini, Kenia Raj, Balakrishnan Logesh, Mishra Chitaranjan

{"title":"AI chatbots in strabismus care: A multidomain expert evaluation of caregiver-facing information.","authors":"Dhiman Shweta, Dutta Paromita, Thacker Prolima, Kaur Savleen, Maniar Ashini, Kenia Raj, Balakrishnan Logesh, Mishra Chitaranjan","doi":"10.1177/11206721261445529","DOIUrl":"https://doi.org/10.1177/11206721261445529","url":null,"abstract":"AimTo evaluate and compare the performance of five artificial intelligence (AI) chatbots-ChatGPT (OpenAI 4), Google Gemini, Grok (xAI), DeepSeek, and Meta Llama -in delivering accurate, clear, educational, and safe responses to caregiver-facing queries related to strabismus.MethodsSixteen standardized caregiver questions on strabismus were presented to each chatbot in independent sessions. Five fellowship-trained pediatric ophthalmologists rated each response across four domains-Accuracy, Clarity, Educational Value, and Safety-using a 5-point Likert scale (1 = Poor, 5 = Excellent). Between-chatbot differences were analyzed using cumulative link mixed models (CLMMs) with odds ratios (OR) and 95% confidence intervals (CI). Holm-adjusted pairwise contrasts corrected for multiple comparisons. Inter-rater reliability was assessed using quadratic-weighted Fleiss' κ and Gwet's AC1 to address prevalence and bias effects.ResultsChatGPT achieved the highest proportion of top ratings (≥4) for Accuracy (65%) and Clarity (59%), followed by Llama (41% and 47.5%, respectively). For Educational Value, Llama (43.8%) and Gemini (42.5%) performed slightly better, while Safety ratings were highest for Gemini (40%) and Llama (37.5%). CLMM analysis showed significant between-chatbot differences for Accuracy, Clarity, and Educational Value (p < 0.05) but not for Safety. Compared with ChatGPT, lower odds of higher ratings were seen for Grok (OR 0.48) and DeepSeek (OR 0.61). Inter-rater reliability indicated moderate agreement (Fleiss' κ = 0.59) and strong consensus (Gwet's AC1 = 0.87).ConclusionChatGPT showed superior accuracy and clarity, while Gemini and Llama excelled in educational value and safety. High expert agreement supports AI chatbots as adjuncts in pediatric ophthalmology education requiring continued validation.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261445529"},"PeriodicalIF":1.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five year of post-marketing safety of teprotumumab: A disproportionality analysis of the FDA adverse event reporting system. teprotumumab上市后5年的安全性：FDA不良事件报告系统的不成比例分析

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-06 DOI: 10.1177/11206721261446011

Jiantong Du, Chen Xing, Zhiyue Zhang, Zonghui Ma

{"title":"Five year of post-marketing safety of teprotumumab: A disproportionality analysis of the FDA adverse event reporting system.","authors":"Jiantong Du, Chen Xing, Zhiyue Zhang, Zonghui Ma","doi":"10.1177/11206721261446011","DOIUrl":"https://doi.org/10.1177/11206721261446011","url":null,"abstract":"PurposeTo evaluate adverse events (AEs) associated with teprotumumab in the reatment of thyroid eye disease (TED).MethodsReports involving teprotumumab were extracted from the U.S.FDA Adverse Event Reporting System (FAERS) from the first quarter of 2020 to the first quarter of 2025. After data standardization, disproportionality analyses were performed using multiple signal detection algorithms, including the Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM).ResultsA total of 1,357 reports were identified. Detected signals at the system organ class (SOC) level included ear and labyrinth disorders, eye disorders, social circumstances and reproductive system and breast disorders. A total of 143 Preferred Terms (PTs) met the criteria of four algorithms. Among these, signals within the \"Ear and labyrinth disorders\" SOC were predominant (n = 598). Tinnitus was the most frequently reported PT (n = 146). The highest disproportionality signals, based on ROR values, were observed for permanent deafness (ROR 10,021.8; 95% CI 5,544.31-18,115.24), autophony (ROR 3,282.12; 95% CI 1,333.19-8,080.12), and patulous eustachian tube (ROR 1,401.68;95% CI 499.54-3,932.99).ConclusionThese findings provide important real-world safety evidence and may support safer clinical use of teprotumumab.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721261446011"},"PeriodicalIF":1.4,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147835095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Macular microcirculation after extraocular muscle surgery: A comparative OCTA study of inferior oblique versus horizontal rectus procedures. 眼外肌手术后黄斑微循环：下斜肌与水平直肌手术的OCTA对比研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2026-02-03 DOI: 10.1177/11206721261419623

Zahid Huseyinhan, Abdullah Ağın, Merve Ozbek, Aynur Diracoglu, Ozgur Artunay

{"title":"Macular microcirculation after extraocular muscle surgery: A comparative OCTA study of inferior oblique versus horizontal rectus procedures.","authors":"Zahid Huseyinhan, Abdullah Ağın, Merve Ozbek, Aynur Diracoglu, Ozgur Artunay","doi":"10.1177/11206721261419623","DOIUrl":"10.1177/11206721261419623","url":null,"abstract":"PurposeTo compare macular microvascular changes after horizontal rectus and inferior oblique (IO) muscle surgeries using swept-source optical coherence tomography angiography (OCTA) and to assess the distinct vascular effects of each surgical approach.MethodsEighty-two pediatric and adolescent patients with concomitant strabismus underwent unilateral extraocular muscle surgery. Group 1 (n = 43) received horizontal rectus muscle surgery; Group 2 (n = 39) underwent IO weakening surgery. The fellow unoperated eye served as a control. Macular microvasculature was evaluated before surgery, at 1 week, and 1 month postoperatively using a swept-source OCTA system. Vessel density (VD) of the superficial capillary plexus (SCP), deep capillary plexus (DCP), and choriocapillaris (CC), as well as the foveal avascular zone area (FAZ), was quantitatively analyzed.ResultsIn the horizontal rectus group, SCP VD significantly increased in the 1st week compared to baseline (49.97% ± 2.41% vs. 51.16% ± 3.23%, p = 0.037) and returned to baseline values in the 1st month. A transient increase in CC VD was also observed at the 1st week (p = 0.006). No significant changes occurred in the DCP and FAZ. In the IO group, no significant changes were found in the SCP, DCP, or FAZ. However, a mild, transient increase in CC VD was observed at the 1st week (p = 0.001), which returned to baseline by the 1st month.ConclusionHorizontal rectus muscle surgery induces significant but transient changes in macular retinal and choroidal perfusion. In contrast, IO muscle surgery induces only localized and temporary choroidal alterations. OCTA may therefore serve as a valuable noninvasive tool for postoperative monitoring of vascular alterations in strabismus surgery.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"737-744"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146111983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of histatin-1, histatin-3, and histatin-5 peptide levels in corneal epithelial cells obtained from patients with keratoconus. 圆锥角膜患者角膜上皮细胞中组他素1、组他素3和组他素5肽水平的研究

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-12-12 DOI: 10.1177/11206721251406428

Cahit Demirkiran, Abdullah Tuncay Demiryürek, Alper Mete, Ahmet Saracaloglu, Mustafa Şahin, Şeniz Demiryürek

{"title":"Investigation of histatin-1, histatin-3, and histatin-5 peptide levels in corneal epithelial cells obtained from patients with keratoconus.","authors":"Cahit Demirkiran, Abdullah Tuncay Demiryürek, Alper Mete, Ahmet Saracaloglu, Mustafa Şahin, Şeniz Demiryürek","doi":"10.1177/11206721251406428","DOIUrl":"10.1177/11206721251406428","url":null,"abstract":"PurposeThe aim of this research was to investigate the contribution of histatin peptides in the pathophysiology of keratoconus.MethodsThis prospective study investigated the presence of histatin peptides in corneal epithelial samples taken from 66 adult patients with keratoconus (stage 1, n = 22; stage 2, n = 21; and stage 3, n = 23) and 20 postmortem controls. The histatin-1, -3, and -5 levels were measured using the ELISA method.ResultsHistatin-3 significantly increased in stage 1 (control, 274.05 ± 15.72 ng/mg total protein, vs. patients, 528.17 ± 47.45 ng/mg total protein, p < 0.001) and stage 2 (374.33 ± 15.05 ng/mg total protein, p < 0.05), but no changes for histatin-1 and -5 levels were observed. Histopathological analysis showed that corneal epithelial cell thickness increased in keratoconus, and this increase augmented proportionally with the stages. The histopathological scores were significantly elevated in stages 2 and 3. Interestingly, positive correlations were observed between histatin-1 and histatin-3 levels in all stages.ConclusionThese preliminary data suggest that histatin-3 may be involved in the early stages of keratoconus. These findings are preliminary and should be confirmed in larger, prospective cohorts.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"631-641"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A paired comparison study on refractive changes after Inferior oblique weakening surgery. 下斜肌减弱手术后屈光变化的配对比较研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-10-17 DOI: 10.1177/11206721251389523

Emine Kaya-Guner, Tuba Colak, Emrah Utku Kabatas, Tuncay Kusbeci, Duygu Inci-Bozbiyik

{"title":"A paired comparison study on refractive changes after Inferior oblique weakening surgery.","authors":"Emine Kaya-Guner, Tuba Colak, Emrah Utku Kabatas, Tuncay Kusbeci, Duygu Inci-Bozbiyik","doi":"10.1177/11206721251389523","DOIUrl":"10.1177/11206721251389523","url":null,"abstract":"BackgroundWe aimed to evaluate the effect of unilateral inferior oblique weakening surgery on refractive parameters by comparing the operated eye with the fellow eye of the same patient.MethodsData of patients who underwent unilateral inferior oblique muscle weakening surgery at our strabismus unit were retrospectively analyzed. Demographic data and refractive values of the patients before and at 6 months postoperatively were recorded. The non-operated eyes were designed as the control group. Cylindrical axes were converted into J0 and J45 vector components. Changes in astigmatism axis were evaluated to assess torsional effects. Clinically significant refractive change was defined as a change ≥ ± 0.75 D in spherical, cylindrical, or spherical equivalent (SE) values.ResultsA total of 44 patients were included. A significant postoperative myopic shift was observed in both spherical and SE values in the operated eyes. Similar changes were noted in the control eyes. The rates of clinically significant refractive change were comparable between operated and control eyes. No statistically significant differences were found between the two groups in terms of changes in spherical, cylindrical, SE, J0, or J45 values. However, vector analysis revealed a clinically insignificant trend toward with-the-rule astigmatic change in operated eyes. There was no significant relationship between eye laterality, gender, or age and changes in SE, J0, or J45.ConclusionInferior oblique weakening surgery does not lead to significant changes in refractive values but may result in minimal shifts in astigmatic axis.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"732-736"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145312615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating anxiety and depression levels in patients undergoing intravitreal injections and investigation of contributing factors. 评估玻璃体内注射患者的焦虑和抑郁水平及影响因素的调查。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-11-03 DOI: 10.1177/11206721251392036

Güzide Akçay, Işıl Kutlutürk Karagöz, Gizem Doğan Gökçe

{"title":"Evaluating anxiety and depression levels in patients undergoing intravitreal injections and investigation of contributing factors.","authors":"Güzide Akçay, Işıl Kutlutürk Karagöz, Gizem Doğan Gökçe","doi":"10.1177/11206721251392036","DOIUrl":"10.1177/11206721251392036","url":null,"abstract":"PurposeTo evaluate anxiety and depression levels in patients receiving intravitreal injections for diabetic macular edema (DME), age-related macular degeneration (AMD), and retinal vein occlusion (RVO), and their associations with visual acuity, disease type, and demographic factors.MethodsThe study included 90 patients (43 males and 47 females) mean age 73.9 ± 12.4 years; (range: 22-92 years). Anxiety levels were assessed using the state anxiety form of the State-Trait Anxiety Inventory (STAI-S), and depression symptoms were assessed using the Hospital Anxiety and Depression Scale (HADS). Best-corrected visual acuity (BCVA) was recorded, and patients were evaluated according to disease type, severity of visual impairment, and number of injections.ResultsThe mean STAI-S score was 36.2 ± 8.9, and that of HADS was 13.9 ± 12.6. There were no significant differences in STAI-S scores between the disease groups (p = 0.17). However, HADS scores were significantly lower in the RVO group than in the DME and AMD groups (p = 0.02, p = 0.04). A significant association was observed between severity of visual impairment and STAI-S scores (p = 0.016), with moderate visual impairment showing higher anxiety levels than mild and severe impairment (p = 0.07, p = 0.02). However, HADS scores were not significantly associated with visual acuity (p = 0.058). Women exhibited higher HADS scores (p = 0.036). Neither injection frequency nor waiting time significantly affected STAI-S or HADS scores (p > 0.05).ConclusionPatients receiving intravitreal injections have varying levels of anxiety and depression, considering disease type, sex, and severity of visual impairment affecting these psychological parameters. These findings provide invaluable insights into the importance of psychological support in ophthalmic care.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"698-704"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

De novo blood within Haab's Striae in congenital glaucoma. 先天性青光眼Haab氏纹内新生血。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2026-01-13 DOI: 10.1177/11206721251412095

Anand Kumar Pathak, Toshit Varshney, Shikha Gupta

{"title":"De novo blood within Haab's Striae in congenital glaucoma.","authors":"Anand Kumar Pathak, Toshit Varshney, Shikha Gupta","doi":"10.1177/11206721251412095","DOIUrl":"10.1177/11206721251412095","url":null,"abstract":"A 7-year-old boy, diagnosed with bilateral congenital glaucoma presented with elevated intraocular pressure (IOP). Anterior segment optical coherence tomography (AS-OCT) of the right eye revealed an artificial plane within the Haab's striae (HS), corresponding to separation of the Descemet membrane-pre-Descemet layer (DM-PDL) complex. Following medical reduction of IOP, slit-lamp examination demonstrated linear reddish discoloration within the HS, which was confirmed on AS-OCT as a hyperreflective intra-lamellar collection of blood between the posterior stroma and endothelium. The eye had not undergone any previous intraocular surgery or trauma. This observation represents a unique instance of de novo intra-lamellar hemorrhage within Haab's striae in an unoperated eye. The presumed mechanism involves reflux of blood into Schlemm's canal, with secondary ingress into the artificial plane created by partial DM-PDL separation, possibly triggered by a Valsalva maneuvre combined with low IOP. This finding underscores the potential anatomical continuity between the PDL and the trabecular meshwork, as previously demonstrated histologically. Recognition of this phenomenon is important to distinguish it from postoperative endothelial hemorrhage or corneal blood staining and to expand our understanding of corneal structural responses in congenital glaucoma. To our knowledge, this is the first reported case demonstrating intra-lamellar bleeding within a pre-existing Haab's striae, documented non-invasively using high-resolution AS-OCT.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"774-775"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145965747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rare case of conjunctival hibernoma in a von Hippel-Lindau (VHL) patient: Possible association? 一例罕见的von Hippel-Lindau （VHL）患者结膜冬眠瘤：可能的关联？

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-12-11 DOI: 10.1177/11206721251406437

Mehmet Omer Kiristioglu, Mehmet Baykara, Saduman Balaban-Adim

{"title":"A rare case of conjunctival hibernoma in a von Hippel-Lindau (VHL) patient: Possible association?","authors":"Mehmet Omer Kiristioglu, Mehmet Baykara, Saduman Balaban-Adim","doi":"10.1177/11206721251406437","DOIUrl":"10.1177/11206721251406437","url":null,"abstract":"PurposeOcular involvement is exceedingly uncommon, and to date, no conjunctival hibernoma has been reported in humans. We present the first such case in a patient with von Hippel-Lindau (VHL) syndrome.Case reportA 32-year-old woman with genetically confirmed type 1 VHL disease presented with a long-standing, progressively enlarging, painless subconjunctival mass in her only functional eye. Systemic history included multiple cerebellar hemangioblastomas, bilateral nephrectomy for renal cell carcinoma, and an endolymphatic sac tumor. Ophthalmic examination revealed a firm, elevated, subepithelial nodular lesion on the bulbar conjunctiva of the left eye, partially prolapsing beyond the palpebral fissure. The lesion was non-tender, non-ulcerated, and showed no surface inflammation. The eye had phthisis bulbi and residual retinal hemangioblastoma. Orbital magnetic resonance imaging demonstrated a 1.2 × 0.9 × 0.7 cm homogeneous, well-circumscribed lesion, hyperintense on T2-weighted fat-suppressed images, confined to the conjunctiva without scleral, orbital, or bony involvement. Surgical excision revealed a cream-gray, lobulated mass composed of multivacuolated eosinophilic cells with granular cytoplasm. Immunohistochemistry showed strong S-100 positivity and low Ki-67, consistent with hibernoma. Despite a positive deep margin, the patient declined further surgery; no recurrence was observed at three months.ConclusionThis is the first documented case of conjunctival hibernoma in humans and the second reported association with VHL. Conjunctival hibernoma should be considered in the differential diagnosis of vascular conjunctival lesions, particularly in patients with VHL.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"719-722"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large asymptomatic intraocular silicone oil droplet following intravitreal injection. 玻璃体内注射后无症状大滴眼内硅油。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-12-26 DOI: 10.1177/11206721251397694

Tu-An Ma, Luke K Chehade, Shane Durkin, Weng O Chan

引用次数: 0

Ocular hypertension and glaucoma after penetrating keratoplasty. 穿透性角膜移植术后的高眼压和青光眼。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2026-05-01 Epub Date: 2025-10-28 DOI: 10.1177/11206721251389055

Batuhan Aygoren, Bora Yuksel, Kusbeci Tuncay, Ipek Cikmazkara, Erel Icel

{"title":"Ocular hypertension and glaucoma after penetrating keratoplasty.","authors":"Batuhan Aygoren, Bora Yuksel, Kusbeci Tuncay, Ipek Cikmazkara, Erel Icel","doi":"10.1177/11206721251389055","DOIUrl":"10.1177/11206721251389055","url":null,"abstract":"PurposeTo report the incidence of glaucoma or ocular hypertension after PK and to determine the risk factors and treatment outcomes.MethodsThe medical records of 381 eyes of 365 patients who underwent penetrating keratoplasty were retrospectively reviewed. The recorded IOP values of the patients during the follow-up period were analyzed. Trabeculectomy was performed in cases of elevated IOP despite maximum medical treatment, and AGV implantation was performed in refractory cases.Results381 eyes of 365 patients, 223 (58.5%) male and 158 (41.5%) female, aged between 18-86 (mean 56.0 ± 18.0) were included in the study. The mean follow-up period was 12-126 months (mean 46.3 ± 28.6). During the follow-up period, post-PK OHT/glaucoma developed after PK in 179 eyes (47.0%). The mean development of OHT/glaucoma after PK was 6.3 ± 11.0 months. Postoperative follow-up IOP > 21 mmHg eye count was 177. The mean postoperative IOP values of these eyes were 27.0 ± 5.9 mmHg. Older recipient age (>50years), elevated preoperative IOP, history of glaucoma in the fellow eye,previous cataract surgery, donor-recipient trephine diameter mismatch otherthan 0.25 mm, larger donor trephine diameter, and additional intraoperative procedures-such as scleral fixation, intraocular lens implantation, anterior vitrectomy,and goniosynechiolysis-were identified as risk factors associated with glaucoma after penetrating keratoplasty.ConclusionsDetermining the risk factors that play a role in the development of OHT/glaucoma after PK, close follow-up of postoperative IOP elevations, and treatment if necessary can preserve visual function and graft transparency for a longer period of time.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"609-617"},"PeriodicalIF":1.4,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0