European Journal of Ophthalmology最新文献

{"title":"Insight into large colloid drusen: A decade-long follow-up.","authors":"Hela Sassi, Alexandra Miere, Francesca Amoroso, Julien Tilleul, Safa Halouani, Salomon Yves Cohen, Eric Souied","doi":"10.1177/11206721251351495","DOIUrl":"https://doi.org/10.1177/11206721251351495","url":null,"abstract":"<p><p>PurposeTo describe the follow-up of large colloid drusen (LCD) through multimodal imaging over a 10-year follow-up period.Materials and MethodsMedical records of patients with a history of LCD were retrospectively analyzed. Inclusion criteria were the presence of bilateral LCD diagnosed at least 10 years before inclusion, having undergone baseline multimodal imaging, including color fundus photography (CF), fundus autofluorescence (FAF), spectral domain optical coherence tomography (SD-OCT) and indocyanine green angiography (ICGA). Ten-year follow-up multimodal imaging included CF, FAF, SD-OCT and swept-source OCT angiography (SS-OCTA). The 10-year FAF pattern and the presence of macular neovascularization (MNV) and/or atrophy were assessed.ResultsTwelve eyes of 6 patients were included in this study. The mean age at diagnosis was 47.83 +/- 7.8 SD years. Best-corrected visual acuity (BCVA) was 0 log MAR at baseline and 0.05 +/- 0.083 log MAR at 10-year follow-up. BCVA at follow-up was maintained at 20/20 in 6 eyes. On SD-OCT, LCDs resorbed in 6 out of 12 eyes, with the development of outer retinal atrophy in 2 eyes and with no atrophy in 4 eyes. Hyperreflective foci (HRF) were noted in 4 eyes. An increase in the height and reflectivity of LCD were found in 2 eyes and coalesced LCDs in 2 eyes. FAF revealed either the persistence of the same pattern of autofluorescence or a speckled autofluorescence of the surrounding ring of LCD. SS-OCTA analysis revealed the presence of a unique case of nonexudative MNV in one out of 12 eyes (8,3%). No cases of fibrosis were detected.ConclusionOver a 10-year multimodal imaging follow-up, LCDs were frequently resorbed. While outer retinal atrophy was occasionally noted, no complete atrophy occurred. Neovascular complications were limited to nonexudative MNV, with no active lesions observed. The 10-year prevalence of nonexudative MNV was 7%. Overall, LCDs showed a more favorable prognosis regarding atrophy and neovascularization compared to other early-onset drusen types.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351495"},"PeriodicalIF":1.4,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiwavelength photobiomodulation in atrophic age-related macular degeneration.","authors":"Federico Beretta, Ilaria Zucchiatti, Riccardo Sacconi, Francesco Bandello, Giuseppe Querques","doi":"10.1177/11206721241298316","DOIUrl":"10.1177/11206721241298316","url":null,"abstract":"<p><p>PurposeTo evaluate photobiomodulation (PBM) safety and efficacy in patient with atrophic AMD and to explore tissue effects using Spectrally Resolved Autofluorescence (SrAF) to identify a potential biomarker indicative of mitochondrial activity, the primary PBM target.MethodsThis retrospective, non-comparative case series involved six eyes of five patients with atrophic AMD, conducted at the Medical Retina and Imaging Unit, IRCCS San Raffaele Hospital in Milan, Italy. At baseline and follow-ups (after one and three months) a complete ophthalmological assessment and multimodal imaging, including spectrally resolved autofluorescence (SrAF), were performed. PBM treatment (Valeda Light Delivery System - LumiThera) was administered in nine sessions over three weeks. The SrAF images were analyzed to evaluate the effect of the treatment.ResultsSix eyes of five patients with atrophic AMD received PBM at baseline. Best corrected visual acuity (BCVA), mean central macular thickness (CMT), mean retinal sensitivity on microperimetry and the atrophic area have remained stable. No eyes developed foveal atrophy after the treatment. The image analysis in SrAF showed an increase in the highlighted area of 4.89% after one month and 17.11% after three months. No adverse systemic or local side effects were reported.ConclusionPBM is a safe treatment for the human retina. The evaluation of the retinal area within the green light spectrum (575 nm) in SrAF is a potential indirect biomarker of mitochondrial activity and could be used to assess treatment efficacy in clinical studies.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1336-1341"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing scleral thickness in patients with POAG and myopia by using OCT.","authors":"Asadullah Jatoi","doi":"10.1177/11206721241302115","DOIUrl":"10.1177/11206721241302115","url":null,"abstract":"<p><p>BackgroundThe aim of the study is to utilize swept-source OCT for imaging the rear sclera near the ONH, calculating the thickness of the SL and lamina, and examining how these measurements correspond to various metrics.DesignCross-sectional design with a prospective approach.Materials and methodsThe study included 96 glaucoma patients and 39 control subjects, all with axial lengths greater than 23 mm. Swept-source OCT was used to visualize the subfoveal and ONH regions. Thicknesses of SL and lamina were then calculated from the \"B-scan\" visuals collected. In order to confirm the consistency of the calculation, \"intraclass correlation coefficients\" were computed from specific \"B-scans\". The study compared the thickness of the SL and lamina in subjects with NTG to those with POAG. A \"Pearson correlation\" was conducted to analyze the connections between the thickness of the SL and lamina with various ocular parameters.ResultsSwept-source OCT enabled the measurement of posterior SL thickness in 65.9% and laminar thickness in 89.8% of the subjects. The consistency of measurements taken by different observers and by the same observer varied from moderate to excellent. There was a notable variation among the NTG and POAG sets in terms of subfoveal SL thickness, with measurements of 680.84 ± 170.60 mm and 486.55 ± 125.21 mm, respectively. The connection among subfoveal SL thickness and axial-length was discovered to be negative in subjects with NTG, but this was not observed in subjects with POAG. The variation in connection among the 2 subject groups was statistically important (r [ L0.687, P < 0.002).Conclusions\"Swept-source OCT\" identified variations in posterior SL thickness between NTG and POAG eyes. The subfoveal scleral thickness showed a negative association with axial-length, particularly in eyes with normal-tension glaucoma.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1264-1271"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142727123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of anti-VEGF treatment-free interval during the first year on 5-year outcomes in eyes with branch retinal vein occlusion.","authors":"Katherine Du, Natasha Mayer, Catalina Feistritzer, Elise Barberis, Ilkay Kilic Muftuoglu, Jay Chhablani","doi":"10.1177/11206721241299855","DOIUrl":"10.1177/11206721241299855","url":null,"abstract":"<p><p>ObjectivesThis study aims to analyze the impact of longest treatment-free interval (TFI) between anti-vascular endothelial growth factor (anti-VEGF) injections during the first year of treatment on 5-year best-corrected visual acuity (BCVA) and recurrence of macular edema (ME) in eyes with ME secondary to branch retinal vein occlusion (BRVO).MethodsA retrospective study including eyes with BRVO, minimum of 5-year follow-up, and available optical coherence topography (OCT) scans. Eyes underwent anti-VEGF loading dose therapy and were treated and monitored with an OCT-guided PRN regimen. Those with a history of ocular comorbidities were excluded.ResultsTotal of 60 patient eyes, with 40 females and average age of 71.75 ± 11.07 years. TFI among eyes was 1 month (20%); > 1-2 months (23%); > 2-3 months (18%); > 3-4 months (17%), and >4 months (22%). Forty-three (72%) eyes experienced ME recurrence during the five-year period. Multivariate linear regression shows that TFI (-0.02 [-0.03-0.00], <i>p</i> = 0.021) and baseline BCVA (0.37 [0.08-0.66], <i>p</i> = 0.014) are significant predictors of 5-year BCVA. TFI (Cox Proportional Hazard Ratio 1.34 [1.04-1.72], <i>p</i> = 0.023) and number of injections in the first year (Cox Proportional Hazard Ratio 1.76 [1.01-3.06], <i>p</i> = 0.045) were significant predictors of ME recurrence. Gender, age, type of injection, BCVA, and CMT did not influence recurrence.ConclusionFor eyes receiving anti-VEGF injections to treat ME secondary to BRVO, TFI is a significant predictor of 5-year BCVA and ME recurrence according to regression models. This study suggests more ME recurrence may be due to increased TFI or indicate more injections needed to treat severe BRVO.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1342-1348"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential role and limitations of antiseptic eyedrops in ophthalmic surgery.","authors":"Carla Danese, Francesco Di Bin, Leopoldo Rubinato, Anna Bulfon, Marco Gonfiantini, Francesca Sinopoli, Carlo Moreschi, Ramin Tadayoni, Paolo Lanzetta","doi":"10.1177/11206721241307995","DOIUrl":"10.1177/11206721241307995","url":null,"abstract":"<p><p>Purposethe aim of the present study is to analyse the composition of the currently available topical antiseptic products and the related scientific evidence, and to discuss the implications of their use in the prevention of endophthtalmitis.Methodsproducts available on the market until February 2024 were considered. Information provided on the illustration leaflet of each product were analysed. Literature search was made on the effectiveness of these new products, focusing on those available in Italy. Articles indexed in Pubmed until June 2024 were included in the present study.Resultslabelling of these products represents an issue, since most of them are presented as eye lubricants and a clear labeling of their indication as perioperative prophylaxis is needed. While promising in vitro studies have been performed, in vivo evidence is still lacking.Conclusionsproducts with antiseptic activity may be promising to address the issue of endophthalmitis prevention. However, more evidence on the subject is needed.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1228-1234"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simple reaction time to visual and auditory stimulation in glaucoma.","authors":"Quentin Lenoble, Jean François Rouland, Matthieu Duault, Muriel Boucart","doi":"10.1177/11206721241310265","DOIUrl":"10.1177/11206721241310265","url":null,"abstract":"<p><p>Background/ObjectivesGlaucoma can impact the ability to perform daily life activities such as driving. In such tasks, reaction time is critical to detect hazards. Understanding the modalities that affect response times is thus essential for clinical care.Subjects/MethodSimple reaction time tasks, in which participants respond as fast as possible to a stimulus, constitute a basic measure of processing speed. Simple reaction times to visual and auditory stimuli were compared to assess whether glaucomatous patients exhibit a general slowing in execution speed or a specific slowing in response to visual signals.Twenty participants with primary open angle glaucoma, 16 age-matched normally sighted controls and 16 young controls were instructed to press the space bar of the computer as soon as they detected a visual (a 3° black ring) or an auditory (a 440 Hz sound) signal. The two modalities were tested in independent blocks of 63 trials.ResultsParticipants with glaucoma were significantly slower than young and older controls in the visual modality but not in the auditory modality, in which simple reaction times did not differ significantly between groups.ConclusionThis study suggests that the reduced processing speed in glaucoma cannot be attributed to motor or attentional impairments and probably results from a delay in the transmission of visual information.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1280-1287"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year results of double site versus single site rigid probe viscotrabeculotomy in primary congenital glaucoma.","authors":"Eman M El Hefney, Eman A Atallah, Hanem Kishk, Ahmed S Elwehidy, Dina Abd Elfattah","doi":"10.1177/11206721241310269","DOIUrl":"10.1177/11206721241310269","url":null,"abstract":"<p><p>Study purposeto compare single- site viscotrabeculotomy in one eye and double-site rigid probe viscotrabeculotomy in the other eye of the same patient with Primary congenital glaucoma to evaluate the effect of the extent of angle treatment on success rate in the study's locality.Patients and MethodsThis prospective randomized study included 70 eyes of 35 children diagnosed with bilateral PCG who attended Mansoura Ophthalmic Center from June 2021 to July 2023. For each patient, one eye underwent single-site rigid probe viscotrabeculotomy (Group S: 35 eyes) and the fellow eye underwent double- site rigid probe viscotrabeculotomy (Group D: 35 eyes). At one-year follow up, complete success was defined as IOP >5 mmHg and ≤16 mmHg without any further IOP-lowering medications and qualified success when IOP ≤16 mmHg with using IOP-lowering medications. Failure was defined as IOP more than 16 mmHg despite the use of IOP-lowering medications, the need for other glaucoma surgery to control IOP or hypotony.ResultsSingle-site rigid probe viscotrabeculotomy showed a one-year complete success rate of 88.57% and for double-site viscotrabeculotomy was 91.43% but the difference was not statistically significant (p-value 0.9). There were no major complications in both groups, hyphema was the most common complication and was self-limitedConclusionSingle-site viscotrabeculotomy shows comparable results to double-site viscotrabeculotomy in PCG preserving more than half of the angle in the former for a second possible angle surgery in recurrent cases.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1295-1304"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbital reactive lymphoid hyperplasia: Case series and literature review.","authors":"Ayodeji Ajanaku, Matthew Fenech, Nima Ghadiri, Sarah E Coupland","doi":"10.1177/11206721241310350","DOIUrl":"10.1177/11206721241310350","url":null,"abstract":"<p><p>This study aimed to describe a case series of patients diagnosed with orbital reactive lymphoid hyperplasia (RLH) at a single tertiary care centre. A retrospective review was conducted by searching electronic medical records at Liverpool University NHS Foundation Trust (LUHFT) from 1^st December 2021 - 1^st December 2023, to identify all patients with a histological diagnosis. Ten patients with an orbital histological diagnosis of RLH were identified. Median age at diagnosis was 56.5 years. Proptosis was the most prevalent presenting symptom, while other signs included palpable mass, ptosis, and diplopia. Eight patients were treated with oral prednisolone, with 20% (two) achieving complete remission. Additional treatments utilised in these cases encompassed doxycycline, mycophenolate, ciclosporin, and azathioprine.This case series represents one of the few reports focusing exclusively on orbital RLH. Notably, bone erosion was observed in this study, a finding that has been scarcely linked to RLH in the literature.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1495-1505"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non arteritic ischemic optic neuropathy in a patient taking semaglutide: Is there a relation? A case report and a review of the literature.","authors":"Martina Maceroni, Paola Sasso, Matteo Giarletti, Valentina Bruno, Angelo Maria Minnella","doi":"10.1177/11206721251331655","DOIUrl":"10.1177/11206721251331655","url":null,"abstract":"<p><p>IntroductionThe glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as Semaglutide, have revolutionized the treatment of type 2 diabetes mellitus and obesity.Case desciptionThe aim of the present study was to report a case of Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) occurring in a diabetic patient taking Semaglutide and to review the literature in order to find a possible relation between the ophthalmological event and the drug intake.DiscussionAlthough the clinical trials of Semaglutide did not report any significant increase in the risk of NAION, a recent retrospective cohort study suggested a possible association between NAION and GLP-1 RAs. After this publication, the association between NAION and Semaglutide became an hot topic and several studies were published, presenting conflicting results.Conclusion and ImportanceAlbeit the association between the use of GLP-1 RAs and NAION, to date, remain controversial, clinicians and ophthalmologists should be aware of such possible association to analyze for each patient the risk-benefit ratio.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP10-NP15"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The performance of ChatGPT-4 and Bing Chat in frequently asked questions about glaucoma.","authors":"Levent Doğan, İbrahim Edhem Yılmaz","doi":"10.1177/11206721251321197","DOIUrl":"10.1177/11206721251321197","url":null,"abstract":"<p><p>PurposeTo evaluate the appropriateness and readability of the responses generated by ChatGPT-4 and Bing Chat to frequently asked questions about glaucoma.MethodThirty-four questions were generated for this study. Each question was directed three times to a fresh ChatGPT-4 and Bing Chat interface. The obtained responses were categorised by two glaucoma specialists in terms of their appropriateness. Accuracy of the responses was evaluated using the Structure of the Observed Learning Outcome (SOLO) taxonomy. Readability of the responses was assessed using Flesch Reading Ease (FRE), Flesch Kincaid Grade Level (FKGL), Coleman-Liau Index (CLI), Simple Measure of Gobbledygook (SMOG), and Gunning- Fog Index (GFI).ResultsThe percentage of appropriate responses was 88.2% (30/34) and 79.2% (27/34) in ChatGPT-4 and Bing Chat, respectively. Both the ChatGPT-4 and Bing Chat interfaces provided at least one inappropriate response to 1 of the 34 questions. The SOLO test results for ChatGPT-3.5 and Bing Chat were 3.86 ± 0.41 and 3.70 ± 0.52, respectively. No statistically significant difference in performance was observed between both LLMs (<i>p</i> = 0.101). The mean count of words used when generating responses was 316.5 (± 85.1) and 61.6 (± 25.8) in ChatGPT-4 and Bing Chat, respectively (<i>p</i> < 0.05). According to FRE scores, the generated responses were suitable for only 4.5% and 33% of U.S. adults in ChatGPT-4 and Bing Chat, respectively (<i>p</i> < 0.05).ConclusionsChatGPT-4 and Bing Chat consistently provided appropriate responses to the questions. Both LLMs had low readability scores, but ChatGPT-4 provided more difficult responses in terms of readability.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1323-1328"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}