European Journal of Ophthalmology最新文献

{"title":"Neurotrophins of the retina and their involvement in early-stage diabetic retinopathy in an animal model of type 1 diabetes mellitus.","authors":"Ewa Sikorska, Kaja Kasarełło, Jacek Dziedziak, Dominika Wołosz, Łukasz Koperski, Agnieszka Cudnoch-Jędrzejewska","doi":"10.1177/11206721251341596","DOIUrl":"https://doi.org/10.1177/11206721251341596","url":null,"abstract":"<p><p>IntroductionDiabetic retinopathy (DR) is a blindness-causing disease which belongs to the group of neurodegenerative diseases. Neurodegeneration of the retina is a process, in which retinal neurons suffer irreversible damage. This study aimed to assess the involvement of neurotrophins (brain-derived neurotrophic factor [BDNF] and nerve growth factor [NGF]) in the pathogenesis of DR.MethodsThe study was performed using male Lewis rats with type 1 diabetes mellitus induced by streptozotocin, and the control group included rats without drug administration. <i>In vivo</i> examinations performed over four weeks included eye fundus imaging, measurement of intraocular pressure, and glycemia. After sacrifice, serum and eyeballs were harvested. <i>Post-mortem</i> analyses included a histopathological analysis of the retina and the measurement of BDNF and NGF levels in the serum and eyeball homogenate.ResultsIn the experimental group, early-stage DR was confirmed, and changes in the retina were observed: diabetic rats had relatively thicker outer nuclear layers and relatively thinner inner plexiform layers. A lower level of BDNF was observed in the serum of rats with DR, while the level of NGF in the eyeball homogenate positively correlated with vascular changes.ConclusionsThe observed changes in the levels of neurotrophins in early-stage DR may indicate their involvement in the disease pathogenesis.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251341596"},"PeriodicalIF":1.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stromal lenticule addition keratoplasty as part of a three-stage procedure for advanced keratoconus: A case report.","authors":"Edna Emilia Gomes da Motta Almodin, Flávia Almodin Camin, Mateus Lins Dos Santos, Paulo Ferrara de Almeida Cunha","doi":"10.1177/11206721251337939","DOIUrl":"https://doi.org/10.1177/11206721251337939","url":null,"abstract":"<p><p>PurposePurpose: To report a case of success of a multimodal therapeutic approach in treating advanced keratoconus using Stromal Lenticule Addition Keratoplasty (SLAK), intrastromal corneal ring segments (ICRS), and phakic posterior chamber intraocular lens (pIOL) implantation.Case ReportA 31-year-old female with advanced keratoconus presented with a history of penetrating keratoplasty (PK) rejection in the right eye and severe visual impairment in the left. The left eye exhibited only hand motion of corrected visual acuity and 220 µm of corneal thickness in the thinnest point, suggesting a complex case for surgical intervention. The initial treatment involved SLAK, utilizing a donor corneal lenticule crafted and implanted using femtosecond laser technology. Subsequent interventions included sequential ICRS for correcting high corneal astigmatism and pIOL implantation to correct high myopia. Only 4 days after the last surgery, the patient had already attained a corrected distance visual acuity of 20/60, improving to 20/30 at day 15 postoperatively.DiscussionThis case highlights the integration of SLAK with other surgical modalities to address multiple aspects of advanced keratoconus. The SLAK procedure provided necessary corneal stabilization and thickness, which facilitated further corrective surgeries. While the literature has discussed SLAK and triple procedures for advanced keratoconus separately, this case uniquely combines these approaches, offering insights into their sequential application and potential synergistic effects.ConclusionsThe combined use of SLAK, ICRS, and pIOL is a promising strategy for managing advanced keratoconus, and provided significant improvements in corneal structure and visual acuity in this case. Further studies are recommended to assess the safety and efficacy of this strategy.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251337939"},"PeriodicalIF":1.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term outcome of Ahmed valve implantation in post -vitrectomy glaucoma patients.","authors":"Arezoo Miraftabi, Zahra Naveed Mehrang, Naveed Nilforushan, Vahid Zarehhosseinabadi, Sadaf Parvin, Makan Ziafati","doi":"10.1177/11206721251338709","DOIUrl":"https://doi.org/10.1177/11206721251338709","url":null,"abstract":"<p><p>PurposeAssessment of the long-term surgical outcomes of AGV implantation in patients with post-vitrectomy glaucoma over a ten-year period at Rassoul Akram Hospital.MethodsAll glaucoma patients who underwent post-vitrectomy AGV implantation at Rassoul Akram Hospital between 2010 and 2020 were evaluated in this retrospective study. The major outcome measures were IOP, medication use, and overall surgical success. A complete success was defined as an IOP of 6-21 mmHg, without any loss of light perception or need for glaucoma medications, or at least a 20% decrease in IOP without the use of medications. Qualifying success was defined similarly, with the use of medications. The cumulative success rates included both qualified and complete success rates.ResultsBetween 2010 and 2020, a total of 76 patients underwent AGV implantation at Rassoul Akram Hospital, met the inclusion criteria. The average duration of follow-up was 30.41 ± 27.16 months. Among the participants, 64.5% were male, and 35.5% were female. The initial IOP readings averaged 28.39 ± 9.75 mmHg; however, the final follow-up showed a decrease to 15.21 ± 5.6 mmHg (P value < 0.01). The Kaplan-Meier survival analysis demonstrated a cumulative success rate of 92.2% at 12 months, which progressively declined to 90.0% at 24 months, 84.2% at 36 months, 69.9% at 48 months, and ultimately reached 64.5% at 60 months.ConclusionThe implantation of an Ahmed valve has proven beneficial in lowering intraocular pressure in post-vitrectomy glaucoma patients, but its efficacy is predicted to decrease with time.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251338709"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PDVR stage A management: Insights from combined PRP and anti-VEGF treatment outcomes.","authors":"Manpreet Brar, Satinderpal Singh Grewal, Gagandeep Singh, Mangat Dogra","doi":"10.1177/11206721251340438","DOIUrl":"https://doi.org/10.1177/11206721251340438","url":null,"abstract":"<p><p>PurposeTo evaluate the outcomes of a combination treatment involving Panretinal photocoagulation (PRP) and Anti-vascular endothelial growth factor (Anti-VEGF) injections in patients with proliferative diabetic vitreoretinopathy (PDVR) at stage A.MethodsRetrospective, non-randomized case series of patients diagnosed with stage A PDVR who received combination treatment with PRP laser and Anti-VEGF injections were enrolled and analyzed in this study. The principal objective of the study was to qualitatively evaluate the worsening of existing fibrovascular proliferation or recurrence of vitreous hemorrhage (VH), retinal neovascularization (NV), and development of new tractional retinal detachment (TRD). Secondary outcomes were changes in visual acuity before or after treatment.ResultsThe study involved 24 eyes from 20 patients with PDVR at stage A and were examined at 4-week and 6-month intervals. The study parameters have shown that the majority of patients (88.72%) either had resolution or stabilization of their retinal diseases. At the 6-month follow-up, worsening of vitreous proliferation traction (VPT) was discovered in 5 eyes (20.8%), while 2 eyes underwent pars plana vitrectomy (PPV). At 4 weeks followup, no new NV emerged in any study eye, however, regrowth of NV was observed in 3 eyes (12.5%) at 6 month followup. Notably, no cases of preretinal hemorrhage (PRH) worsened during the study period. VH was either resolved or stabilized in all study eyes at 4 weeks, but worsening of VH was noted in 2 eyes at the 6-month follow-up. Our treatment showed improvement in logMAR Best corrected visual acuity of patients eyes from baseline to 4 weeks, 6 months, was 0.5 ± 0.41, 0.39 ± 0.34, and 0.32 ± 0.31, respectively.ConclusionThe combined treatment of PRP laser and Anti-VEGF injections can effectively control the disease progression, stabilize vision, and avoid the need for vitrectomy in early-stage PDVR. Long-term studies are essential to validate the sustained efficacy and safety of this treatment strategy.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340438"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic correlations and multimodal imaging of vitreoretinal metastasis from breast carcinoma.","authors":"Andrea Montesel, Basil Suresh, Caroline Thaung, Siegfried K Wagner, Ben Kirkpatrick, Hung-Da Chou, Amit Arora, William R Tucker, Angela Rees","doi":"10.1177/11206721251340582","DOIUrl":"https://doi.org/10.1177/11206721251340582","url":null,"abstract":"<p><p>PurposeTo present a case of non-uveal intraocular metastatic disease originating from relapsed breast carcinoma.MethodsWe report a 67-year-old female with a history of HER2-positive breast carcinoma in remission and recent squamous cell carcinoma of the esophagus presenting with ocular symptoms. Comprehensive ophthalmic examinations and multimodal imaging were performed. Diagnostic procedures included diagnostic vitrectomy and cytology analysis.ResultsThe patient was found to have metastatic carcinoma to the vitreous and retina with an immunophenotype compatible with breast carcinoma. Neurological symptoms led to the discovery of metastatic brain lesions. The patient underwent palliative systemic treatment and stereotactic brain irradiation. Follow-up showed the progression of the ocular lesions.ConclusionThis case informs on the clinical and pathological findings of a rare non-uveal intraocular metastatic disease originating from relapsed breast carcinoma. Vitreous biopsy and multimodal imaging were required for a proper diagnosis and management and would serve as a reference for further cases.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340582"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of myopic maculopathy and related factors of its subtypes and visual outcomes in a Colombian population.","authors":"María Alejandra Gómez-Rocha, Carlos Mario Rangel, Juan David Arias, Alejandro Tello, Virgilio Galvis, Sylvia J Villamizar, Sergio Mancero, Germán Mejía-Salgado","doi":"10.1177/11206721251340431","DOIUrl":"https://doi.org/10.1177/11206721251340431","url":null,"abstract":"<p><p>PurposeTo evaluate the diagnostic and prognostic utility of the atrophy-traction-neovascularization (ATN) classification in characterizing myopic maculopathy (MM) and identifying factors influencing its subtypes and visual outcomes.Methods228 eyes (136 patients) with high myopia [spherical equivalent (SE) ≤ -6.00 diopters (D) or axial length (AL) ≥ 26.5 mm] were assessed. Ocular evaluations included optical coherence tomography and ocular biometry. MM was classified into three subtypes: myopic atrophy-maculopathy (MAM), myopic tractional-maculopathy (MTM), and myopic neovascular-maculopathy (MNM). Final corrected-distance-visual-acuity (CDVA), AL, and SE were compared between eyes with and without MM and its subtypes. Univariate and multivariate models were used to identify related factors in each subtype: moderate-severe vision impairment (final CDVA between 20/70-20/400) and blindness (final CDVA < 20/400).ResultsMM was present in 58.8% of cases, 52.2% had MAM, 27.2% MNM and 14% MNM. Notably, fifteen eyes (11.2%) exhibited traction or neovascularization without atrophy. Eyes with MM exhibited worse BCVA, more negative SE, and longer AL than those without MM (p < 0.001). AL ≥ 30 mm was related to MAM (OR = 1.51; 95% CI 1.30-3.00; p = 0.004) and MNM (OR = 9.36; 95% CI 1.56-13.08; p = 0.021). Blindness was related to aged ≥ 50 years (OR = 2.80; 95% CI 1.30-6.05; p = 0.010), MTM (OR = 1.90; 95% CI 1.80-4.80; p = 0.029), and MNM (OR = 5.60; 95% CI 2.78-15.55; p = 0.005).ConclusionThe ATN classification is valuable for diagnosing and prognosing MM, as it identifies subtypes and key factors influencing visual outcomes. Notably, tractional and neovascular changes, detected in ATN but often undetectable on fundus photography, were linked to worse visual prognosis, reinforcing its clinical relevance.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340431"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of MicroPulse transscleral laser therapy with the revised P3 delivery device: A randomized controlled trial.","authors":"P Connor Lentz, Isabella V Wagner, Devesh Kumar, Nithya Boopathiraj, Bryan C H Ang, Abhimanyu Ahuja, Leticia Checo, Darby D Miller, Syril Dorairaj","doi":"10.1177/11206721251340102","DOIUrl":"https://doi.org/10.1177/11206721251340102","url":null,"abstract":"<p><p>ObjectiveTo evaluate the safety and efficacy of MicroPulse Transscleral Laser Therapy (MicroPulse TLT) with the Revised P3^® Delivery Device.DesignProspective, single-surgeon, interventional study in a tertiary hospital setting.ParticipantsSixty-two eyes of 40 patients with refractory glaucoma.MethodsAll subjects received 360-degree MicroPulse TLT treatment (2500 mW, 31.33% duty cycle) over a total of 240 s (8 sweeps; <i>n</i> = 20), 300 s (10 sweeps; <i>n</i> = 22), or 200 s (10 sweeps; <i>n</i> = 20). Participants were followed up for 6 months to assess changes in intraocular pressure (IOP), glaucoma medication burden, and best-corrected visual acuity (BCVA). Surgical success was defined as a reduction of IOP ≥ 30% from baseline and between 6-18 mmHg at last follow-up with no additional anti-glaucoma medications or secondary reinterventions.ResultsSurgical success was achieved in 72.7% (300 s group), 75.0% (240 s group), and 80.0% (200 s group) of eyes. Mean IOP was significantly reduced (<i>p</i> < 0.001) by 49.0% (300 s group), 45.66% (240 s group), and 39.8% (200 s group) at 6 months. With all groups combined, the mean number of glaucoma medications was significantly reduced by 17.8% (<i>p</i> = 0.005), and no significant changes in BCVA were observed at 6 months. Complications were minimal, including four eyes with IOP spikes, one eye with hyphema, and one eye with cystoid macular edema (CME), all of which resolved. Two eyes of the total sample (3.2%) required secondary glaucoma surgery before 6 months.ConclusionsSecond-generation MicroPulse TLT at fluence values of 154-229 J/cm² appears to be a safe and effective option for IOP reduction in refractory glaucoma.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340102"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Butterfly-shaped pattern dystrophy complicated by retinal pigment epithelium tear - case report.","authors":"Zuzana Anwarzai Sulavikova","doi":"10.1177/11206721251341121","DOIUrl":"https://doi.org/10.1177/11206721251341121","url":null,"abstract":"<p><p>IntroductionTo report a rare case of a 71-year-old male with bilateral butterfly-shaped pattern dystrophy (BPD) who developed a retinal pigment epithelium (RPE) tear in the left eye. Pattern dystrophies are a group of autosomal dominant macular diseases characterized by various patterns of pigment deposition within the RPE. While pattern dystrophies typically carry a favorable visual prognosis, complications such as RPE tears are exceedingly rare.Case presentationInitial examination revealed bilateral butterfly-shaped lesions consistent with pattern dystrophy, with a central oval RPE tear detected in the left eye. Despite three injections of bevacizumab, no functional changes were observed and persistent visual impairment was noted during follow-up.ConclusionThis case highlights the rare occurrence of an RPE tear as a complication of butterfly-shaped pattern dystrophy.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251341121"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Next generation sequencing in children with isolated congenital cataract.","authors":"Gunay Amanova, Esra Er, Esra Isik, Ebru Canda, Turkan Turkut Tan, Asude Durmaz, Sema Kalkan Ucar, Ayca Aykut, Tahir Atik, Mahmut Coker, Onder Uretmen, Ozgur Cogulu","doi":"10.1177/11206721251340844","DOIUrl":"https://doi.org/10.1177/11206721251340844","url":null,"abstract":"<p><p>PurposeCongenital cataracts (CC) are a preventable cause of childhood blindness, accounting for approximately 10% of cases. A significant portion of CC cases remains idiopathic. Genetic diagnosis can eliminate unnecessary tests and ensure appropriate follow-up and treatment. This study aimed to evaluate the etiology of CC without known etiological reasons in 10 families using whole exome sequencing (WES).MethodsTen families participated in this study, with all patients undergoing comprehensive ophthalmological, metabolic, and genetic assessments. DNA samples from the probands were analyzed using WES, and variants were verified and validated through Sanger sequencing.ResultsOf the 10 patients diagnosed with isolated CC, 9 (90%) had bilateral cataracts, and 1 (10%) had unilateral cataract. Nuclear type cataracts were detected in 8 (80%) patients, while polar type cataracts were found in 2 (20%) patients. Parental consanguinity was present in 7 out of the 10 families. An unidentified variant in the <i>RAB3GAP1</i> gene (c.491C > G) associated with Martsolf syndrome was found in one patient. Two novel and one previously identified gene variants associated with CC were detected in 3 of the remaining 9 patients: a novel c.463C > T in <i>CRYGD</i>, a previously identified c.965dup in <i>HSF4</i>, and a novel c.3330C > A in <i>FYCO1</i>.ConclusionThe high rate of consanguineous marriages in Turkey (23.3%) increases the incidence of autosomal recessive (AR) diseases, explaining the higher prevalence of AR CC despite its usual autosomal dominant inheritance. In conclusion, WES is a valuable tool in determining the etiology of isolated CC.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340844"},"PeriodicalIF":1.4,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis on the clinical correlation of lens parameters and choroidal thickness with the severity of primary angle closure disease.","authors":"Vijayalakshmi A Senthilkumar, Sayali Borikar, Niyati Pankaj Gandhi, Iswarya Mani, Sharmila Rajendrababu","doi":"10.1177/11206721251340230","DOIUrl":"https://doi.org/10.1177/11206721251340230","url":null,"abstract":"<p><p><b>Purpose:</b> The purpose of this study is to investigate the correlation of lens parameters and choroidal thickness (RCS) with the severity of PACD and to compare those parameters with the normal population. <b>Methods:</b> Prospective, cross-sectional hospital-based study. A total of 286 subjects (572 eyes) including 236 study patients (472 eyes) and 50 age-matched controls (100 eyes) were included in the study. The parameters studied were anterior chamber depth (ACD), lens thickness (LT), anterior vault (AV), lens axial factor (LAF), lens position (LP), relative lens position (RLP), lens vault (LV) and RCS thickness. <b>Results:</b> The mean ACD was significantly shallow in all subtypes of Primary Angle Closure Glaucoma (PACG) (mean ± <i>SD</i> = 2.53 ± 0.34 mm) compared to controls (4.05 ± 0.16; <i>p</i> = 0.0001). Likewise, the mean lens thickness was more in all subtypes of PACD (mean ± <i>SD</i> = 4.67 ± 0.26 mm) than in normal controls (4.17 ± 0.17 mm; <i>p</i> = 0.0001). Moreover, PACD patients had higher LV (mean ± <i>SD</i> = 1174.29 ± 247.87) than in controls (778.23 ± 37.95; <i>p</i> = 0.0001), particularly in eyes with <b>AAC</b> (1328.86 ± 77.13). Other biometric parameters like AV, LAF, LP, RLP and RCS thickness revealed a statistically significant difference in PACD compared to the control population (<i>p</i> < 0.00001). Pairwise comparison also revealed significant difference in all ocular biometric parameters in <b>AAC</b> compared to other subtypes. <b>Conclusion:</b> Lens parameters and choroidal thickness correlated significantly with the severity of PACD. Our study highlights the interplay of multiple ocular biometric parameters with the disease severity, suggesting the individualised surgical options in patients with PACD.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340230"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}