European Journal of Ophthalmology最新文献

{"title":"Phaco + iStent implant learning curve in a teaching hospital.","authors":"Diogo Bernardo Matos, Rafael Correia Barão, Nuno Pinto Ferreira, Riccardo Peschiera, Afonso Cabrita, Bruno Dias, André Diogo Barata, Luís Abegão Pinto","doi":"10.1177/11206721251363047","DOIUrl":"https://doi.org/10.1177/11206721251363047","url":null,"abstract":"<p><p>Purpose<i>iStent inject^® W</i> is a minimally invasive surgical device aimed at creating an alternative trabecular drainage of aqueous humour, reducing intraocular pressure (IOP). International reports already support efficacy and safety, but evidence is lacking about the early-stage learning curve for this device.SettingThis research was conducted in a teaching tertiary hospital in Lisbon, Portugal.DesignRetrospective study on the first 6 <i>iStent inject^® W</i> implants performed by 6 certified ophthalmic surgeons.MethodsAll procedures were combined with cataract surgery (phaco + iStent inject^® W). Primary outcome was total surgical time. Secondary outcomes were complications and postoperative IOP. Outcome data were collected preoperatively and at postoperative days 1, 7, 30, and 90.ResultsThirty-six patients were included (58% female). Mean age was 73.28 ± 9.65 years. Mean surgical time of first surgery was 35.16 min (range 20 to 55), with surgical time decreasing by 8.5 min throughout the learning curve. Mean preoperative IOP was 21.81 ± 4.74 mmHg with a mean need of 2 medications. At 1-month, mean IOP was 16.00 ± 3.12 mmHg (-26.64% than baseline) while resorting to less medication (2.00 ± 0.94 to 0.66 ± 0.95; <i>p</i> < 0.01). Trabecular meshwork haemorrhage was the most common intra-operative complication reported, and no surgical complications requiring secondary intervention were recorded.Conclusions<i>iStent inject^® W</i> was perceived as a fast-learning procedure, with a significant safety profile in the first cases. The magnitude of IOP reduction of this combined procedure makes it an interesting approach to the glaucoma patient requiring cataract surgery, performed either by a resident under supervision or a glaucoma consultant.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251363047"},"PeriodicalIF":1.4,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orbit management sans exenteration with retrobulbar injection of amphotericin-B in Rhinoorbitocerebral mucormycosis: Impact on survival.","authors":"Shubashree Karat, Aaron Charles Lobo, Anita Ross, Anna Philip, Thenmozhi Nagarajan, Suneetha Nithyanandam","doi":"10.1177/11206721251361276","DOIUrl":"https://doi.org/10.1177/11206721251361276","url":null,"abstract":"<p><p>PurposeThis study aims to describe the impact on survival of non-exenteration management of orbital disease, supplemented with transcutaneous retrobulbar injection of amphotericin B (TRAMB), in a cohort of patients with COVID-19-associated ROCM, a life-threatening condition for which exenteration is generally the preferred treatment modality.MethodThis retrospective cohort study included 69 COVID-19-associated ROCM patients. All patients were treated with intravenous liposomal amphotericin-B and surgical debridement of paranasal sinuses. All patients with orbital disease were treated with TRAMB (42/69); orbital debridement or extended enucleation was performed when the disease was severe or progressive; debridement of intracranial disease was done when indicated.ResultsOf the 69 patients included, at discharge, 45/69(65.2%) had cured/stable ROCM, 13/69(18.8%) died and 11/69(15.94%) were discharged on request, with progressive disease. The vision was preserved in 45/69(65%), a blind eye with preserved ocular globe in 18/69(26%), and 6/69(9%) underwent extended enucleation. At 18 months follow-up, 6/56 died, 13/56 were lost to follow-up and 37/56 were alive. The cumulative mortality was 27% (19/69). Independent risk factors for mortality were increasing age(<i>p</i> = 0.003), diabetic ketoacidosis(<i>p</i> = 0.006), severe COVID-19 (<i>p</i> = 0.04), and CNS involvement (<i>p</i> = 0.01).ConclusionIn this study, conservative orbit management sans exenteration augmented with retrobulbar injection of amphotericin B was an effective treatment modality for orbital involvement in ROCM. The mortality in our patients was comparable to reports where exenteration was the first line of treatment, with better vision and cosmetic outcomes. Further studies comparing orbit conservation with TRAMB versus exenteration may be needed to delineate further, whether this approach can be an alternative to exenteration.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251361276"},"PeriodicalIF":1.4,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of topical insulin as a therapeutic intervention for corneal wounds: A comprehensive systematic review and meta-analysis.","authors":"Dillan Cunha Amaral, Carolina Carvalho Soares Valentim, Lidia Cheidde, Laura Cheidde, Pedro Paulo Ladeira Júnior, Elizabet Taylor Pimenta Weba, Kenzo Ogasawara Donato, Helvécio Neves Feitosa Filho, Jaime Guedes, Ricardo Noguera Louzada","doi":"10.1177/11206721251361649","DOIUrl":"https://doi.org/10.1177/11206721251361649","url":null,"abstract":"<p><p>BackgroundPersistent epithelial defects (PEDs) are challenging corneal conditions with prolonged non-healing. Commonly associated with dry eye disease and neurotrophic keratopathy, PEDs can lead to severe complications. Topical insulin has emerged as a therapeutic option, promoting epithelial healing.MethodsWe searched Medline, Embase, Web of Science, and Cochrane Library databases following PRISMA guidelines for studies reporting topical insulin for PEDs of any etiology and corneal epithelial defect (CEDs) post-vitrectomy. Healing time, complete wound healing (CWH), epithelization failure (EF), and epithelial healing rate were our analysis outcomes. Statistical analyses employed random-effects models and I² statistic.ResultsThirteen studies involving 390 eyes were included. Mean healing time for all conditions was 20.68 days (95% CI: 11.60, 29.76) with significant heterogeneity. The pooled CWH rate was 94% (95% CI: 0.87, 0.98), with an odds ratio of 5.41 favoring topical insulin over the control group. EF was low at 5% (95% CI: 0, 0.13), and the epithelial healing rate was 0.82 mm²/hour (95% CI: 0.02, 1.62). Subgroup analyses revealed variations.ConclusionsTopical insulin is effective in corneal wound healing, demonstrating high CWH rates and low failure rates. Further well-controlled studies are needed to validate these findings and assess long-term outcomes.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251361649"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144689666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the DIGIROP algorithm in identifying preterm infants at risk for developing retinopathy of prematurity in a Belgian NICU.","authors":"Sophie Vanhaesebrouck, Aleksandra Zecic, Linde Goossens, Annelies Keymeulen, Lara Garabedian, Julie De Meulemeester, Pauline Naessens, Kris De Coen, Koenraad Smets","doi":"10.1177/11206721251362054","DOIUrl":"https://doi.org/10.1177/11206721251362054","url":null,"abstract":"<p><p>PurposeRetinopathy of prematurity (ROP) is a blinding disease, however largely preventable by timely detection of severe ROP and treatment when required. Clinical use of the DIGIROP decision support tool (DIGIROP-screen and DIGIROP-birth) can help detecting neonates at high risk of sight-threatening severe ROP needing treatment and to reduce unnecessary screening exams in low-risk infants. External validation is necessary before the tool can be used in clinical decision-making.MethodsRetrospective cohort analysis of all preterm infants who were screened for ROP at the University Hospitals Ghent Belgium from January 1, 2020, to December 31, 2022. Validation of the DIGIROP decision support tools was the primary outcome variable. In a secondary analysis pre-, peri-, and postnatal characteristics were compared in different cohorts.Results311 infants were eligible for routine ROP-screening. Infants with a (gestational age) GA beyond 30 weeks (N = 80) and those who died (N = 19) were excluded resulting in 212 infants eligible entered in DIGIROP-birth. 112 infants did not need to be screened according to DIGIROP-birth. This resulted in 94 infants entered in DIGIROP-screen. These infants had a median GA of 27 weeks, a median birth weight (BW) of 892.5 g, and 62.5% were boys. DIGIROP birth showed a sensitivity of 100%. Most important risk factors for ROP across all subgroups are GA, BW.ConclusionsThe DIGIROP decision support tool demonstrated very high performance in our setting. However, multicenter prospective validation studies with large cohorts should confirm our findings before the use of the model can be generalized in Western NICU's with similar levels of care.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251362054"},"PeriodicalIF":1.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified four incomplete petals evisceration technique: A 14 year case series.","authors":"Albert Arnaiz-Camacho, Tirso Alonso, Joan Oliveres, Miguel-Ángel Arcediano, Oscar Balaguer, Yann Bertolani, Tatiana Pablos-Jiménez, Sara García-Hidalgo, Armand Pairó-Salvador, Miguel-Ángel Zapata","doi":"10.1177/11206721251361272","DOIUrl":"https://doi.org/10.1177/11206721251361272","url":null,"abstract":"<p><p>PurposeThe aim of this article is to describe the outcomes of a case series using our own variation of the four-petal evisceration technique which may minimize the rate of orbital implant exposure through a simple approach.MethodsOur new technique consists of incompletely dividing the first two scleral flaps, thus creating four incomplete petals that can be sutured over the orbital implant. A case series with a minimum follow-up of 12 months is reported.ResultsOne hundred and twenty-two eyes of 121 patients who underwent evisceration surgery using the described technique are included. No cases of implant exposure or extrusion were observed, and an ocular prosthesis could be adapted in all cases with no complications during a minimum follow-up of 12 months.ConclusionsThe modified \"incomplete\" four-petal evisceration technique is a safe and accessible technique that may help prevent orbital implant exposure and can be considered a valid alternative in various clinical scenarios.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251361272"},"PeriodicalIF":1.4,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144674221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors of late intraocular Lens displacement: A multi-national study.","authors":"Chimwemwe Chipeta, Jufen Zhang, Max Davidson, Ahmed B Sallam, Joseph Toma, Beatrice Gallo, Evgenia Anikina, Amanda Ie, Mayuresh Naik, Kanmin Xue, Omkaar Sivanesan, Sonali Tarafdar, Shane Whitlow, Danny Mitry, Mandeep Singh Bindra, Marta Latasiewicz, Loic Sermeus, Kai Januschowski, Andrew Davies, Ken Kawamoto, Rabia Bourkiza, Amee Patel, Kurt Spiteri-Cornish, Virginija Vilkelyte, Conor Ramsden, Francesco Maria D'Alterio, Maria T Sandinha, Stratos Gotzaridis, Shahina Pardhan, Aman Chandra","doi":"10.1177/11206721251358006","DOIUrl":"https://doi.org/10.1177/11206721251358006","url":null,"abstract":"<p><p>PurposeTo examine potential risk factors of late intraocular lens displacement (LIOLD); a rare complication of cataract surgery believed to be due to progressive zonular insufficiency which is often managed with pars plana vitrectomy (PPV) and intraocular lens (IOL) exchange.Setting16 centers across the UK, Germany and GreeceDesignRetrospective case control studyMethodsCases of LIOLD occurring between June 2018 and January 2023 were identified. Demographics, biometry data, previous medical and ocular history were interrogated and multivariate logistic regression was performed.Results434 eyes experiencing LIOLD were identified. 20,321 eyes not experiencing LIOLD during the same period formed the control group. Following multivariate analysis, YAG capsulotomy (OR 17.17, 95% CI 12.44-23.70, <i>p</i> < 0.001), pseudoexfoliation (OR 15.63, 95% CI 10.78-22.64, <i>p</i> < 0.001), complicated cataract surgery (OR 17.60, 95% CI 12.94-23.95, <i>p</i> < 0.001), previous PPV (OR 4.86, 95% CI 3.50-6.75, <i>p</i> < 0.001), younger age at cataract surgery (OR 0.94, 95% CI 0.93-0.95, <i>p</i> < 0.001) and axial myopia (OR 1.16, 95% CI 1.09-1.24, <i>p</i> < 0.001) were identified as risk factors. Female sex was associated with reduced risk (OR 0.64, 95% CI 0.51-0.80, <i>p</i> < 0.001). Patients having cataract surgery under 60 years had an increased risk (40 years OR 2.90, 30 years OR 4.92).ConclusionRisk factors are known to vary by geographical location and our study being the first multinational study provides a significant contribution. Future studies may look at prevention for at-risk individuals and compare outcomes of different IOL fixation techniques.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251358006"},"PeriodicalIF":1.4,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular lens stability and factors affecting refractive error following modified Yamane technique without trimmed haptics.","authors":"Sawako Koutari, Takahiko Hayashi, Kyohei Fujiwara, Hiroshi Aso, Harumasa Yokota, Kentaro Yuda, Tadashiro Saeki, Satoru Yamagami","doi":"10.1177/11206721251357124","DOIUrl":"https://doi.org/10.1177/11206721251357124","url":null,"abstract":"<p><p>PurposeTo evaluate intraocular lens stability and identify factors affecting postoperative refractive errors following modified Yamane sutureless intrascleral fixation without trimmed haptics.Major FindingsForty-four eyes were included: 22 each from Surgeons A and B cases (mean patient age, 66.8 ± 13.7 years). Postoperative best-corrected visual acuity (BCVA; logarithm of the minimum angle of resolution [logMAR]) was also not significantly different: 0.23 ± 0.40 logMAR and 0.22 ± 0.41 logMAR for Surgeons A and B, respectively. Regarding the position of fixated IOLs, postoperative tilt was 6.33 ± 3.8° for Surgeon A, and 5.51 ± 3.17° for Surgeon B. Postoperative decentration was 0.46 ± 0.22 mm for Surgeon A, and 0.49 ± 0.24 mm for Surgeon B. Postoperative refractive error was 0.43 ± 0.75 D (range: -1.00-1.70 D) for Surgeon A and -0.18 ± 1.35 D (range: -3.50-2.20 D) for Surgeon B, showing a slight hyperopic tendency for Surgeon A. Postoperative refractive errors showed a significant positive correlation with postoperative aqueous depth (<i>P</i> = 0.016).ConclusionsRefractive error stability and centration were not inferior to those reported in previous studies. Differences in postoperative refractive error tendencies were observed between the two surgeons, with postoperative aqueous depth being a significant influencing factor.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251357124"},"PeriodicalIF":1.4,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-year follow-up of eye bank prepared pre-loaded DMEK vs. pre-cut UT-DSAEK grafts.","authors":"Mohit Parekh, Pia Leon, Matteo Airaldi, Alessandro Ruzza, Stefano Ferrari, Antonella Franch, Vito Romano","doi":"10.1177/11206721251357126","DOIUrl":"https://doi.org/10.1177/11206721251357126","url":null,"abstract":"<p><p>PurposeTo compare the difference of long-term clinical outcomes between eye bank prepared pre-loaded (pl)-DMEK (endo-in technique) and pre-cut (pc)-ultra-thin (UT)-DSAEK grafts.MethodIn this retrospective single center interventional case series, patients were treated for Fuchs endothelial corneal dystrophy (FECD) using pl-DMEK (<i>n</i>=47) and pc-UT-DSAEK grafts (<i>n</i>=42). The grafts were prepared, loaded and transported in an IOL cartridge (pl-DMEK) or in the storage media (pc-UT-DSAEK) by a single eye-bank. All the grafts were delivered by a single surgeon using bimanual pull-through technique. Post-operative outcomes were monitored up to 3 years. The main outcome measures were early post-operative complications, best corrected visual acuity (BCVA) and endothelial cell density (ECD) at years 1, 2 and 3.Resultpl-DMEK showed a significantly higher rebubbling rate (21.3%) compared to pc-UT-DSAEK (4.8%; <i>p</i> < 0.001). pl-DMEK group showed a significant improvement in visual acuity (logMAR) at years 1 (0.06 vs 0.13), 2 (0.05 vs 0.12) and 3 (0.05 vs 0.12) (<i>p</i> < 0.05) compared to the pc-UT-DSAEK group. Mean endothelial cell density (cells/mm²) of pl-DMEK grafts did not differ (<i>p</i> > 0.05) compared to pc-UT-DSAEK grafts at year 1 (1745 vs 1789), year 2 (1553 vs 1495) and year 3 (1422 vs 1280).ConclusionDespite higher immediate post-operative complications in pl-DMEK, long-term clinical outcomes remain comparable or better than pc-UT-DSAEK grafts. Eye bank prepared grafts are therefore safe and reliable for challenging EK procedures.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251357126"},"PeriodicalIF":1.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RE: Evaluating the novel role of ChatGPT-4 in addressing corneal ulcer queries: An AI-powered insight.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1177/11206721251357482","DOIUrl":"https://doi.org/10.1177/11206721251357482","url":null,"abstract":"","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251357482"},"PeriodicalIF":1.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to letter regarding \"Evaluating the novel role of ChatGPT-4 in addressing corneal ulcer queries: An AI-powered insight\".","authors":"Bharat Gurnani, Kirandeep Kaur","doi":"10.1177/11206721251357376","DOIUrl":"https://doi.org/10.1177/11206721251357376","url":null,"abstract":"","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251357376"},"PeriodicalIF":1.4,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}