European Journal of Ophthalmology最新文献_第2页

Multimodal imaging and functional outcomes of choroidal metastases from non-small cell lung cancer treated with targeted therapy. 靶向治疗非小细胞肺癌脉络膜转移的多模式成像和功能结果。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-06 DOI: 10.1177/11206721251337129

Giuliano Gualandi, Francesco Romano, Francesca Lamanna, Chiara Preziosa, Giovanni Staurenghi, Marco Pellegrini

{"title":"Multimodal imaging and functional outcomes of choroidal metastases from non-small cell lung cancer treated with targeted therapy.","authors":"Giuliano Gualandi, Francesco Romano, Francesca Lamanna, Chiara Preziosa, Giovanni Staurenghi, Marco Pellegrini","doi":"10.1177/11206721251337129","DOIUrl":"https://doi.org/10.1177/11206721251337129","url":null,"abstract":"PurposeTo evaluate the long-term outcomes of next-generation tyrosine kinase inhibitor (TKI) therapy in patients with choroidal metastases (CMs) secondary to non-small cell lung cancer (NSCLC).Major FindingsThis case series includes five eyes from three patients with stage IV NSCLC and CMs. All patients presented with unilateral visual loss, though two exhibited bilateral choroidal lesions on multimodal imaging, including fundus photography, dye-based angiography, optical coherence tomography (OCT), and ultrasonography. Systemic evaluation confirmed ALK-rearranged NSCLC (case 1) and EGFR-mutated NSCLC (cases 2 and 3), leading to first-line treatment with Alectinib and Osimertinib, respectively. Within months of therapy initiation, significant anatomical and visual improvements were noted, with complete lesion resolution and photoreceptor restoration by 6 months. At final follow-up (24-36 months), high-resolution OCT showed residual granularity in the outer retinal layers, while OCT angiography (OCTA) revealed persistent choriocapillaris flow voids. Microperimetry demonstrated distinct functional alterations based on lesion location.ConclusionsThis series highlights favorable long-term outcomes in NSCLC patients with CMs treated with next-generation TKIs. It underscores the value of multimodal imaging and functional assessments in monitoring disease progression and treatment response, emphasizing the importance of early targeted therapy in optimizing visual outcomes.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251337129"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Play, pressure, and pachychoroid: A case series on e-sports players. 游戏，压力和厚脉络膜：电子竞技选手的案例系列。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-06 DOI: 10.1177/11206721251340092

Mehmet Cem Sabaner, Irem Gunes, Fatih Gurdal, Elon H C van Dijk, Prithvi Ramtohul, Yousif Subhi

{"title":"Play, pressure, and pachychoroid: A case series on e-sports players.","authors":"Mehmet Cem Sabaner, Irem Gunes, Fatih Gurdal, Elon H C van Dijk, Prithvi Ramtohul, Yousif Subhi","doi":"10.1177/11206721251340092","DOIUrl":"https://doi.org/10.1177/11206721251340092","url":null,"abstract":"PurposeThe pachychoroid disease spectrum is characterized by choroidal thickening, vascular hyperpermeability, and structural alterations in the choroidal circulation. This can lead to central serous chorioretinopathy (CSC), which is clinically seen as retinal pigment epithelium detachments and subretinal fluid accumulation. Despite the fact that corticosteroid exposure is a main risk factor for CSC, its pathogenesis is unknown. This paper describes a case series in which individuals engaged in competitive video gaming presented with pachychoroid disease, and sheds light on the impact of prolonged screen exposure and e-sports-related stress on pachychoroid disease.Case presentationWe report 8 male e-sports players diagnosed with pachychoroid disease, including 6 with CSC and 2 with uncomplicated pachychoroid. All reported average daily screen exposure of 5-10 h and heightened stress during tournaments. Some cases resolved with lifestyle changes, while others required medical intervention. Reduction in video gaming and stress was correlated with symptomatic improvement.ConclusionsHigh-intensity e-sports may contribute to pachychoroid disease through prolonged screen exposure and sustained stress. Live streaming and competitive pressure may amplify these effects. Stress management and regulated screen time could mitigate risks. This case series highlights a possible association between prolonged gaming stress and pachychoroid disease. Awareness and the implementation of preventive measures are essential for maintaining ocular health in e-sports players. Further research with larger cohorts is needed.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340092"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the macula pigment optical density by a psychophysical test in dry age-related macular degeneration. 干性老年性黄斑变性的心理物理测试评价黄斑色素光密度。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-06 DOI: 10.1177/11206721251339507

Feyza Çalış Karanfil, Emin Özmert

{"title":"Evaluation of the macula pigment optical density by a psychophysical test in dry age-related macular degeneration.","authors":"Feyza Çalış Karanfil, Emin Özmert","doi":"10.1177/11206721251339507","DOIUrl":"https://doi.org/10.1177/11206721251339507","url":null,"abstract":"PurposeTo evaluate the macular pigment optical density (MPOD) in dry age-related macular degeneration (AMD).MethodsThis prospective study included 68 dry AMD patients and, as the control group, 91 healthy volunteers. Age, gender, family history, smoking, alcohol, hypertension, hyperlipidemia, height, weight, dietary lutein intake, and use of lutein-zeaxanthin (L-Z) were questioned. Full ophthalmic examination was performed. Color fundus photography and fundus autofluorescence (FAF) images were recorded. MPOD was measured by color perimetry (CP) every 3 months for 9 months in the dry AMD group, and 1 time at the beginning of the study in the control group. 6 mg/day lutein or 10 mg/day L and 2 mg/day Z were started in non-users.ResultsSmoking, obesity, family history, light iris color, and hyperlipidemia were seen more frequently in the AMD group. Average MPOD values in the AMD group were; 3.69 ± 1.82 (baseline), 4.74 ± 1.29 (3rd month), 4.99 ± 1.27 (6th month), and 5.02 ± 1.35 (9th month) dB, respectively. In the control group, the average MPOD was 4.97 ± 1.27 dB. At the baseline, the MPOD of the AMD group was significantly lower than the control group. Smoking, obesity, poor dietary lutein intake, light iris color, and hyperlipidemia were associated with low MPOD.DiscussionThe relationship between MPOD and AMD is controversial in the literature. Low MPOD and AMD may be related depending on our results. Quit smoking, and having a rich dietary L-Z intake are important for preventing AMD progression. The results of the CP are consistent with the other psychophysical tests.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251339507"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autologous corneal patch for simultaneous bilateral perforation in Sjögren's syndrome. A case report. 自体角膜贴片治疗Sjögren综合征双侧同时穿孔。一份病例报告。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-06 DOI: 10.1177/11206721251340231

Giacomo Scotti, Nicola Cardascia, Maria Gabriella La Tegola, Giacomo Boscia, Linda Pomes, Francesco Boscia, Giovanni Alessio

{"title":"Autologous corneal patch for simultaneous bilateral perforation in Sjögren's syndrome. A case report.","authors":"Giacomo Scotti, Nicola Cardascia, Maria Gabriella La Tegola, Giacomo Boscia, Linda Pomes, Francesco Boscia, Giovanni Alessio","doi":"10.1177/11206721251340231","DOIUrl":"https://doi.org/10.1177/11206721251340231","url":null,"abstract":"PurposeTo present a case of simultaneous bilateral corneal perforation in a patient affected by Sjögren syndrome (SjS) successfully managed with corneal transplantation on the left eye and placing an autologous corneal patch on the right eye.ObservationsA 71-year-old woman with SjS presented at our attention complaining of pain, redness, and blurred vision in both eyes persisting for 4 days. Clinical and instrumental investigations led to the diagnosis of bilateral corneal perforation in the context of Sjögren syndrome. Therapeutic contact lenses were initially placed, followed by surgical intervention using an autologous corneal patch for the right eye and a corneal transplant for the left eye. Postoperative recovery was successful, with stable corneal condition and normal intraocular pressure observed at 3 and 6-months follow-ups.Conclusions and importanceThis case underscores the complexity of managing SjS-related ocular complications and propose the use of autologous corneal patches to minimize immune rejection risks in cases where corneal transplantation cannot be performed.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340231"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of perimetric progression in ocular hypertension and open angle glaucoma based on corneal biomechanics. 基于角膜生物力学预测高眼压和开角型青光眼的周距进展。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-06 DOI: 10.1177/11206721251340439

Marta I Martínez-Sánchez, Gema Bolívar, Anna Dastiridou, Alberto Castaño, Carolina Bertoncini, Carlos Alonso, Purificación Escámez, Miguel A Teus

{"title":"Prediction of perimetric progression in ocular hypertension and open angle glaucoma based on corneal biomechanics.","authors":"Marta I Martínez-Sánchez, Gema Bolívar, Anna Dastiridou, Alberto Castaño, Carolina Bertoncini, Carlos Alonso, Purificación Escámez, Miguel A Teus","doi":"10.1177/11206721251340439","DOIUrl":"https://doi.org/10.1177/11206721251340439","url":null,"abstract":"PurposeTo identify parameters that are significant risk predictors of visual field (VF) progression in patients with ocular hypertension (OHT) or early primary open-angle glaucoma (POAG), using Goldmann applanation tonometry intraocular pressure (IOP-GAT), ultrasound pachymetry and biomechanical indices measured with the Corvis ST and the Ocular Response Analyser (ORA) and create a prediction model.MethodsA dataset of 65 eyes was analyzed. VF progression was determined using event analysis, the AGIS progression criteria, and experts' opinion. Progression was defined when 2 of the 3 criteria agreed on VF progression. The artificial intelligence training pipeline to predict the consolidated target consisted of an initial outlier removal process, feature selection, and training using the leave-one-out (LOO) cross-validation. Techniques based on decision trees with the XGBoost (Xtreme Gradient Boosting) algorithm were employed.ResultsThe results reveal that the most accurate predictors were those registered at 1-month follow-up, predicting glaucomatous VF progression with an accuracy of 86.2%. The main variables involved in the prediction were HC dArc length, HC Deflection Time, and the HC Deflection Length 1 month after PG therapy.ConclusionUsing AI models, glaucomatous VF progression can be predicted with relatively high accuracy using Corvis ST parameters registered one month after initiating PG treatment. Highest concavity parameters after 1 month of treatment are associated with an increased risk of perimetric progression.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340439"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol delamination and topical mitomycin-C 0.02% for the treatment of corneal intraepithelial neoplasia. 酒精分层和外用0.02%丝裂霉素c治疗角膜上皮内瘤变。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-06 DOI: 10.1177/11206721251340235

Marco Messina, Davide Tucci, Maria Poddi, Luca Pagano, Carlo Cagini

{"title":"Alcohol delamination and topical mitomycin-C 0.02% for the treatment of corneal intraepithelial neoplasia.","authors":"Marco Messina, Davide Tucci, Maria Poddi, Luca Pagano, Carlo Cagini","doi":"10.1177/11206721251340235","DOIUrl":"https://doi.org/10.1177/11206721251340235","url":null,"abstract":"PurposeTo report a case of a patient diagnosed with corneal intraepithelial neoplasia (CIN) with ocular discomfort and blurred vision, successfully treated with alcohol delamination (ALD) and topical mitomycin-C.MethodsA 69 year-old man underwent a full slit lamp examination which revealed the presence of a superficial corneal lesion appearing as an opaque intraepithelial plaque extending from the limbus to the visual axis. A manifest refraction with a best corrected visual acuity (BCVA), an anterior segment OCT (AS-OCT) and a corneal topography were performed. In order to remove the lesion an ALD was carried out and the obtained tissue sample was sent for histopathological evaluation confirming the diagnosis of CIN. At the end of the procedure, a bandage contact lens was applied, and the eye was started on a topical treatment with Netilmicin 3% and Dexamethasone 1% 4 times daily for 15 days and mitomycin-C 0.02% drops four times a day, on alternate weeks for 4 weeks.ResultsPatient's symptoms improved and BCVA was restored to 20/20 over 1-month period. The ocular surface showed a significant regularization, clinically and both at the AS-OCT and corneal topography. Three years after the procedure patient's BCVA and refraction were stable without any sign of recurrence.ConclusionsALD is a safe and inexpensive procedure when dealing with CIN allowing both clinical improvements and a definitive histopathological diagnosis.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251340235"},"PeriodicalIF":1.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term results of direct laser trabeculoplasty (DSLT) in clinical practice. 直接激光小梁成形术（DSLT）的近期临床效果。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-04 DOI: 10.1177/11206721251339511

Beatriz Puerto, Carmen Sánchez-Sánchez, Cristina López-Caballero, Aurora Pérez-Crespo, Jorge Casco, Inés Contreras

{"title":"Short-term results of direct laser trabeculoplasty (DSLT) in clinical practice.","authors":"Beatriz Puerto, Carmen Sánchez-Sánchez, Cristina López-Caballero, Aurora Pérez-Crespo, Jorge Casco, Inés Contreras","doi":"10.1177/11206721251339511","DOIUrl":"https://doi.org/10.1177/11206721251339511","url":null,"abstract":"PurposeTo report the short-term results of direct selective-laser trabeculoplasty (DSLT) in clinical practice.MethodsRetrospective review of patients treated with DSLT between December 2023 and May 2024 with ≥ 6 months follow-up. Eyes were divided according to the indication for DSLT: first-line treatment (group 1); treatment-burden reduction (group 2) and additional intraocular pressure (IOP) lowering effect (group 3). Success was defined as a decrease of ≥ 20% from baseline-IOP with no additional treatment, or as a reduction in hypotensive drugs with stable IOP.ResultsSeventy-six eyes from 44 patients were included. In group 1 (20 eyes) mean IOP dropped from 26.50 ± 2.70 mmHg at baseline to 20.35 ± 3.37 mmHg six months after DSLT (p < 0.001). No eye required topical treatment. In group 2 (28 eyes), mean baseline IOP was 15.36 ± 4.34 mmHg and remained stable at 14.75 ± 4.15 mmHg (p = 0.214). Mean number of hypotensive drugs dropped from 2.00 ± 0.72 to 1.07 ± 1.24 (p < 0.001). In group 3 (28 eyes), mean IOP dropped from 20.21 ± 5.42 mmHg to 16.54 ± 4.37 mmHg (p < 0.001), with mean number of drugs remaining stable: 1.71 ± 0.76 at baseline and 1.57 ± 0.88 six months after DSLT (p > 0.05). There were no serious adverse events. Success rates were 55% in group 1, 57.1% in group 2 and 39.3% in group 3.ConclusionsDSLT produced an IOP reduction of almost 25% in naive eyes and 17% in already-treated eyes. It can also reduce treatment burden with a stable IOP. These results support DSLT as an option at all stages of glaucoma, although the duration of its effect remains to be proven.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251339511"},"PeriodicalIF":1.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling restrictive strabismus in a Complex presentation With residual esotropia - A case report. 限制性斜视的复杂表现及残余内斜视1例报告。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-04 DOI: 10.1177/11206721251338702

Stevie Kresentia, Luki Indriaswati

{"title":"Unveiling restrictive strabismus in a Complex presentation With residual esotropia - A case report.","authors":"Stevie Kresentia, Luki Indriaswati","doi":"10.1177/11206721251338702","DOIUrl":"https://doi.org/10.1177/11206721251338702","url":null,"abstract":"IntroductionThe onset of ocular misalignment can be either congenital or acquired, with each type of strabismus exhibiting distinct clinical features that help differentiate it from others. In this case, we aim to discuss conditions that mimic restrictive strabismus and their management.Case descriptionA 14-year-old girl presented with a complaint of her left eye turning inward, which had been present since infancy. Clinical examination revealed bilateral medial rectus overaction. She had underwent surgery for a meningocele five years ago. The left eye examination: visual acuity was 2/60, anterior segment was normal, esotropia, and a -3 limitation of abduction and the force duction test was positive. She was diagnosed with congenital esotropia, with restrictive esotropia considered as a differential diagnosis. She underwent surgery to released cicatricial tissue and recession rectus medial. After the surgery, the left eye esotropia still remained. Neuroimaging was conducted to identify the underlying cause. The result described left fronto-orbital meningoencephalocele caused fibrosis around the left medial rectus tendon. A second surgery involving lateral rectus resection was performed, and orthophoria was achieved at both eyes.ConclusionsThis case report illustrates that any abnormalities involving the orbital structures can be a potential cause of restrictive strabismus, especially when certain clinical features are incongruent with the initial diagnosis. Meticulous history taking and thorough clinical examination are essential to achieve an accurate diagnosis and management.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251338702"},"PeriodicalIF":1.4,"publicationDate":"2025-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Three-years follow-up of combined phacoemulsification, iStent and endocyclophotocoagulation. 超声乳化术、体外吸入术及内环光凝术联合随访3年。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-02 DOI: 10.1177/11206721251338996

Celia Fernandez-Alcalde, Lee Jones, Anca Delia Pantalon, Gokulan Ratnarajan

{"title":"Three-years follow-up of combined phacoemulsification, iStent and endocyclophotocoagulation.","authors":"Celia Fernandez-Alcalde, Lee Jones, Anca Delia Pantalon, Gokulan Ratnarajan","doi":"10.1177/11206721251338996","DOIUrl":"https://doi.org/10.1177/11206721251338996","url":null,"abstract":"ObjectivesTo assess the efficacy and safety of phacoemulsification combined with endocyclophotocoagulation (ECP) and iStent implantation in surgically naïve patients.MethodsRetrospective observational cross-sectional series of 82 surgically naïve eyes treated with combined phacoemulsification, ECP and iStent between January 2018 and July 2019 at a single centre facility.ResultsA total of 82 eyes underwent the procedure. Average age was 80.9 (±6.4) years and 61% were female. Fifteen (18.29%) eyes had preperimetric glaucoma, the remaining were primary open angle glaucoma as follows: mild 32.92% (N = 27), moderate 35.37% (N = 29) and advanced 13.41% (N = 11). Baseline mean IOP was 19.5 (±4.5) mmHg, falling to 14.4 (±3.2) mmHg at 36-months (p ≤ 0.001). 82% of eyes were a qualified success at 3-year post-op with IOP ≤ 18 mmHg. 26% of eyes were a complete success at 3-years with IOP ≤ 18 mmHg and no medications. At baseline, mean number of medications was 2 reducing to 1.3 ± 1.1 at 3-years; Nineteen (23.2%) were patients medication-free. Best corrected visual acuity improved, increasing from 0.28 ± 0.2 LogMAR preoperatively to 0.10 ± 0.1 LogMAR at 36-months follow-up (p ≤ 0.001). Two patients developed cystoid macular oedema that resolved with topical treatment. Average MD remained stable over 3-years (p = 0.94). Due to suboptimal IOP, 3 patients underwent selective laser trabeculoplasty (SLT). No patients required further glaucoma surgical intervention.ConclusionsCombination of cataract surgery with iStent and ECP is a safe and effective procedure to lower IOP and medication burden. The procedure halted glaucoma progression and prevented further surgery over a 3-years follow up.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251338996"},"PeriodicalIF":1.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nontargeted metabolomics analysis in allergic conjunctivitis. 过敏性结膜炎的非靶向代谢组学分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-02 DOI: 10.1177/11206721251338495

Nagihan Demirtas, Onur Senol, Emine Cinici, Büşra Sahin Mazlumoglu, Mehmet Atakay, Bekir Salih, Saziye Sezin Palabiyik-Yucelik

{"title":"Nontargeted metabolomics analysis in allergic conjunctivitis.","authors":"Nagihan Demirtas, Onur Senol, Emine Cinici, Büşra Sahin Mazlumoglu, Mehmet Atakay, Bekir Salih, Saziye Sezin Palabiyik-Yucelik","doi":"10.1177/11206721251338495","DOIUrl":"https://doi.org/10.1177/11206721251338495","url":null,"abstract":"PurposeAllergic conjunctivitis is a disease with a high prevalence in the world. In this study, untargeted metabolomics analyzes were performed to investigate the metabolic profile of the disease in serum samples of allergic conjunctivitis patients.MethodsSerum samples were obtained from 20 allergic conjunctivitis patients and 20 healthy subjects. Untargeted metabolomics analyzes were performed by LC/Q-TOF/MS (liquid chromatography quadrupole time-of-flight mass spectrometry) method. Data collection, classification and identification were performed with the METLIN database and XCMS.ResultsA total of 152 different metabolites were identified and labeled. All annotated metabolites exhibited a 1.5-fold change (increase or decrease) and had a p-value of less than or equal to 0.05 when comparing groups. All statistical data indicated that the model was statistically significant and the p-value is less than or equal to 0.05. All annotated metabolites were evaluated and pathway analysis were performed with significantly altered metabolites.ConclusionIn this study, significant differences in histamine, fatty acid, sphingolipid, purine, vitamin and melatonin metabolism were observed in allergic conjunctivitis patients. It has been determined that disruption of the cell barrier due to changes in fat metabolism, activation of inflammation pathways and irregularity in sphingolipid metabolism play an important role in the underlying mechanisms of allergic conjunctivitis.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251338495"},"PeriodicalIF":1.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0