Ali Kubilay Kolik, Aslıhan Çetinbaş Genç, Filiz Vardar, Kemal Turgay Özbilen, Özden Boral, Nesimi Büyükbabani
{"title":"Boraginaceae plant fragment as a foreign body in the lacrimal duct: Multidisciplinary diagnosis","authors":"Ali Kubilay Kolik, Aslıhan Çetinbaş Genç, Filiz Vardar, Kemal Turgay Özbilen, Özden Boral, Nesimi Büyükbabani","doi":"10.1177/11206721241282350","DOIUrl":"https://doi.org/10.1177/11206721241282350","url":null,"abstract":"Foreign bodies in the lacrimal drainage system pose a substantial challenge in clinical practice due to their potential morbidity and diverse origins. Many foreign bodies are inorganic; however, organic foreign bodies, although uncommon, present diagnostic challenges. We present the case of a 57-year-old woman who had epiphora in her right eye. Patient's physical examination suggested an obstruction in the nasolacrimal duct. An external dacryocystorhinostomy (DCR) was scheduled. The surgery uncovered a polyp-like intrasaccal structure, which was subsequently identified as an organic foreign body through a comprehensive histopathological examination. This case underscores the significance of precise histopathological evaluation, multidisciplinary collaboration, and meticulous assessment in the identification of uncommon intraorbital organic foreign bodies.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142220141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ecem Önder Tokuç, V Levent Karabaş, Mehmet Orkun Sevik, Fatih Bilgehan Kaplan, Işıl Kutlutürk Karagöz, Hatice Selen Kanar, Uğur Yayla, Ayşe Demirciler Sönmez, Aslan Aykut, Utku Limon, Erdinç Bozkurt, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Nimet Yeşim Erçalık, Esra Kumral Türkseven, Özlem Aydın Öncü, Erkan Çelik, Ece Başaran Emengen, Abdullah Özkaya, Banu Açıkalın Öncel, Nursal Melda Yenerel, Özlem Şahin
{"title":"Efficacy of ranibizumab and aflibercept on reducing maximum diameter of largest cyst in diabetic cystoid macular edema: MARMASIA study group.","authors":"Ecem Önder Tokuç, V Levent Karabaş, Mehmet Orkun Sevik, Fatih Bilgehan Kaplan, Işıl Kutlutürk Karagöz, Hatice Selen Kanar, Uğur Yayla, Ayşe Demirciler Sönmez, Aslan Aykut, Utku Limon, Erdinç Bozkurt, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Nimet Yeşim Erçalık, Esra Kumral Türkseven, Özlem Aydın Öncü, Erkan Çelik, Ece Başaran Emengen, Abdullah Özkaya, Banu Açıkalın Öncel, Nursal Melda Yenerel, Özlem Şahin","doi":"10.1177/11206721241280737","DOIUrl":"https://doi.org/10.1177/11206721241280737","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the effect of intravitreal aflibercept (IVA) and ranibizumab (IVR) on the maximal diameter of the largest intraretinal cyst (mdIRC), indicating chronicity in patients with diabetic cystoid macular edema (CME).</p><p><strong>Methods: </strong>This retrospective, comparative study included a subgroup of patients from the MARMASIA Study with treatment-naïve diabetic CME who had IVA (IVA group) or IVR (IVR group) on a pro re nata regimen after a loading dose of 3-monthly injections and followed-up for 24 months. Best-corrected visual acuity (logMAR), central macular thickness (CMT, µm), and mdIRC (µm) and their changes during the study period in the IVA and IVR groups were compared.</p><p><strong>Results: </strong>A total of 175 eyes (65 [37.1%] in IVA and 110 [62.9%] in IVR group) of 113 patients were included in the study analysis. Both groups had statistically significant improvements in BCVA and CMT during the follow-up (p < 0.05 for all), which were comparable between the groups at each time point. However, the mean reduction in mdIRCs was consistently and significantly higher in the IVA group compared to the IVR group at each follow-up examination (F[1, 3.52] = 6.93, p = 0.009).</p><p><strong>Conclusion: </strong>IVA seems to have a greater impact in reducing cyst sizes than IVR in diabetic CME.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concurrent delayed recurrence of peripheral primitive neuroectodermal tumors in orbital and sellar/suprasellar regions in an older adult.","authors":"Shota Yamashita, Michiko Yokosawa, Sadahide Ono, Takayuki Sugawara, Naoto Kimura, Hidenori Endo","doi":"10.1177/11206721241277251","DOIUrl":"https://doi.org/10.1177/11206721241277251","url":null,"abstract":"<p><strong>Background: </strong>Peripheral primitive neuroectodermal tumors (pPNETs) are rare and aggressive small round cell tumors, tending to occur in the thoracic and paravertebral soft tissues in children and young adults. This report describes an exceptionally rare case of concurrent delayed recurrence of pPNET in the orbital and sellar/suprasellar regions in an older adult, with a discussion supported by a literature review.</p><p><strong>Case presentation: </strong>We report an 82-year-old woman with a history of orbital pPNETs resection at age 62, followed by gamma knife radiosurgery for local recurrence at age 66. She presented left eye pain, left eye protrusion, decreased vision in the right eye, and right homonymous hemianopia. MRI revealed extensive lesions in the left orbital cavity and sellar/suprasellar region, contiguous through the optic canal. The recurrent tumor was treated through a two-stage resection via transcranial and transsphenoidal approaches, which resulted in symptom improvement and a pathologic diagnosis of pPNETs.</p><p><strong>Conclusion: </strong>This case highlights a highly rare instance of late-onset orbital pPNETs recurrence in an elderly patient, with evidence suggesting tumor progression into the sellar/suprasellar regions through the optic canal.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Terence Ang, Jessica Y Tong, Sandy Patel, Dinesh Selva
{"title":"Differentiation of bacterial orbital cellulitis and diffuse non-specific orbital inflammation on magnetic resonance imaging.","authors":"Terence Ang, Jessica Y Tong, Sandy Patel, Dinesh Selva","doi":"10.1177/11206721241272227","DOIUrl":"https://doi.org/10.1177/11206721241272227","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the radiological differences between bacterial orbital cellulitis (OC) and diffuse non-specific orbital inflammation (DNSOI) on magnetic resonance imaging (MRI).</p><p><strong>Methods: </strong>Retrospective study of patients with OC and DNSOI with an MRI orbital scan. Localised orbital inflammation (e.g., idiopathic dacryoadenitis and myositis), quiescent orbital inflammation and pre-septal cellulitis were excluded.</p><p><strong>Results: </strong>Thirty-two patients presenting between 2008 and 2023, including twenty-one OC patients (mean age: 42.5 ± 24.9 years old, male: 6), and eleven DNSOI patients (mean age: 52.3 ± 17.8 years old, male: 16). Both OC and DNSOI demonstrate orbital fat contrast-enhancement. However, whilst OC demonstrated a hyperintense T2 signal (P < 0.001), variable signal was observed in DNSOI, with a hypointense T2 signal more suggestive of DNSOI (P = 0.012). When the lacrimal glands were involved, indistinct margins were more likely in OC (P < 0.001), whilst gross enlargement and contrast-enhancement was observed in DNSOI (P = 0.032 and 0.017, respectively). Peripheral contrast-enhancement of the extraocular muscle (EOM) (P = 0.002) was more common in OC, whilst DNSOI demonstrated variable contrast-enhancement throughout the affected EOM (P < 0.001). The presence of contralateral abnormalities, such as lacrimal gland enlargement and EOM involvement, are more suggestive of DNSOI.</p><p><strong>Conclusion: </strong>Several MRI features, beyond overt sinogenic disease, may help to differentiate OC from DNSOI, including the orbital fat signal intensity, EOM and/or lacrimal gland involvement, and contralateral orbital abnormalities. However, these features may not be specific, and thus highlights the ongoing radiological dilemma clinicians are faced when tasked with differentiating between infectious and non-infectious orbital inflammatory disease.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ramin Salouti, Ali Azizi, Hesam Hashemian, Masoud Khorrami-Nejad, Qassim Alkhafaji, Kia Salouti, Maryam Ghoreyshi, M Hossein Nowroozzadeh
{"title":"A comparison of white-to-white measurements obtained by Anterion AS-OCT versus three optical devices in refractive surgery candidates.","authors":"Ramin Salouti, Ali Azizi, Hesam Hashemian, Masoud Khorrami-Nejad, Qassim Alkhafaji, Kia Salouti, Maryam Ghoreyshi, M Hossein Nowroozzadeh","doi":"10.1177/11206721241281876","DOIUrl":"https://doi.org/10.1177/11206721241281876","url":null,"abstract":"<p><strong>Background and objectives: </strong>To assess the agreement between Anterion AS-OCT and three optical devices in measuring the white-to-white (WTW) diameter in candidates for refractive surgery.</p><p><strong>Methods: </strong>In this cross-sectional prospective study, 129 right eyes of 129 normal individuals underwent consecutive scans with the Anterion, the Pentacam AXL, the IOLMaster 700, and the Orbscan IIz. Mean difference (MD), 95% limits of agreement (LoA), and concordance correlation coefficient (CCC) were calculated to assess agreement and interchangeability.</p><p><strong>Results: </strong>The mean age of participants was 30.4 ± 5.9 (range: 21-47) years. The mean WTW distance measured by the different instruments was as follows: 12.00 ± 0.42 mm (range, 10.57 to 13.05) using the Anterion, 11.87 ± 0.34 (11.10 to 12.80) using the Pentacam, 12.12 ± 0.44 (11.00 to 13.30) using the IOLMaster, and 11.73 ± 0.37 (11.00 to 13.10) using the Orbscan. The MD and 95% LoA for Anterion vs. Pentacam, IOLMaster, or Orbscan were [0.11; -0.31 to 0.54 mm], [-0.13; -0.93 to 0.66], and [0.25; -0.28 to 0.78], respectively. The corresponding CCCs were 0.803, 0.514, and 0.631.</p><p><strong>Conclusions: </strong>This study found weak agreement between Anterion and Pentacam AXL, IOLMaster 700, and Orbscan IIz devices regarding WTW distance measurements in refractive surgery candidates. Therefore, it is not recommended to use Anterion's WTW measurements interchangeably with the other three devices, particularly for phakic intraocular lens sizing.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical coherence tomography angiography analysis in patients with intracranial hypertension.","authors":"Lidia Remolí-Sargues, Clara Monferrer-Adsuara, Belén López-Salvador, Carolina García-Villanueva, Alicia Gracia-García, Verónica Castro-Navarro, Enrique Cervera-Taulet","doi":"10.1177/11206721241228349","DOIUrl":"10.1177/11206721241228349","url":null,"abstract":"<p><strong>Introduction: </strong>Evidence on peripapillary microvasculature in intracranial hypertension (IH) after the regression of papilledema is still scarce. The aim of this preliminary study was to determine the association between structural changes in the optic nerve and the retina and peripapillary microvasculature in patients with IIH.</p><p><strong>Methods: </strong>We conducted a retrospective study. The study included 39 eyes of 21 patients with IIH. Treatment for IIH and history of obesity were registered from each patient. Moreover, OCT analysis including retinal nerve fiber layer (RNFL) thickness and ganglion cell-inner plexiform layer (GCIPL) thickness, and OCTA analysis including perfusion density (PD) and flux index (FI) of the radial peripapillary capillary plexus were performed.</p><p><strong>Results: </strong>Correlation analysis revealed a high correlation between GCIPL thickness and peripapillary PD and FI (<i>p</i> < 0,05, <i>r</i> > 0,7), whereas the degree of correlation between RNFL thickness and peripapillary microvascular parameters was low (<i>p</i> < 0,05, <i>r</i> < 0,7). Patients with regressed papilledema had significantly lower GCIPL thickness and peripapillary PD than control subjects (<i>p </i>< 0,05).</p><p><strong>Conclusion: </strong>Peripapillary microvascular measurements are highly correlated with GCIPL thickness in patients with IIH. Moreover, GCIPL thickness and peripapillary PD are significantly inferior in patients with regressed papilledema compared to control group. Thus, we suggested that peripapillary microvascular parameters may be an early indicator of optic nerve atrophy in patients with IIH.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139520361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Impact of weight reduction on structural and functional parameters of the optic nerve in idiopathic intracranial hypertension.","authors":"Mousumi Banerjee, Swati Phuljhele, Rohit Saxena, Pradeep Sharma, Vasundhra Misra, Deepti Vibha, Awadh Kishor Pandit","doi":"10.1177/11206721241232038","DOIUrl":"10.1177/11206721241232038","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of weight reduction on the structural and functional parameters of the optic nerve in established cases of papilledema in Idiopathic Intracranial Hypertension (IIH).</p><p><strong>Methods: </strong>A prospective observational study in early and established cases of papilledema in IIH presenting from December 2019 to February 2021. Functional parameters (visual acuity, contrast sensitivity, mean deviation, VER), structural parameters (RNFL, GCL-IPL, and optic disc height), and clinical grading of papilledema were measured at baseline and every 6 weeks for 6 months. All patients underwent medical (oral acetazolamide) and diet therapy.</p><p><strong>Results: </strong>Mean body mass index (BMI) at presentation was 26.32 ± 3.52 kg/m² and the mean change in BMI over 6 months was 1.27 ± 0.50 kg/m². 67% of eyes had papilledema of grades 2-3 at the presentation. At the end of 6 months, 75% of eyes had grade 1 papilledema while 13% showed complete resolution. A reduction of 5.32 ± 3.58 in mean deviation (r = 0.316; p-value 0.01) and gain in VER P100 amplitude of 4.2 ± 2.7 µV (r = 0.40; p-value 0.003) were noted over 6 months with reduction in BMI over 6 months. A statistically significant reduction in optic disc height (ODH) was noticed with BMI reduction over 6 months (p = 0.0007; r = 0.45).A reduction of 1.72 ± 0.90 kg/m² (<i>equivalent to 6.53% weight loss</i>) in BMI was associated with a four-grade change in clinical grading of papilledema.</p><p><strong>Conclusion: </strong>Reduction in BMI had a significant impact on both structural and functional parameters of the optic nerve in IIH. The involvement of a well-certified dietician should be an integral part of treatment in IIH.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karl Anders Knutsson, Beatrice Tombolini, Giorgio Paganoni, Paolo Rama, Francesco Bandello
{"title":"Unusual presentation of ocular surface squamous neoplasia in a young healthy patient: A case report.","authors":"Karl Anders Knutsson, Beatrice Tombolini, Giorgio Paganoni, Paolo Rama, Francesco Bandello","doi":"10.1177/11206721241256150","DOIUrl":"10.1177/11206721241256150","url":null,"abstract":"<p><strong>Purpose: </strong>To report an unusual case of ocular surface squamous neoplasia (OSSN) associated with human papilloma virus (HPV)-16 infection with an atypical morphology in a young otherwise healthy patient.</p><p><strong>Case description: </strong>A 17 year-old healthy male was referred to our department for evaluation of a corneal infiltrate with anterior stromal neovascularization in the right eye. One year before, the patient underwent an excision of a corneo-conjunctival lesion that was located inferiorly in the same eye. Histopathological analysis had shown moderate and severe dysplasia of the conjunctival epithelium and resulted positive for HPV-16. We performed a diagnostic incisional biopsy of the limbal conjunctiva and of the corneal epithelium for histological examination and molecular testing for HPV and Chlamydia by using polymerase chain reaction (PCR). Histopathologic evaluation demonstrated low-grade dysplasia of conjunctiva. PCR testing of the corneal epithelium was positive for HPV-16, similarly to the first biopsy performed by another centre. The patient was successfully treated with topical interferon alfa-2b (1,000,000 IU/ml) for a total of six months. After the treatment, the corneal infiltrate improved dramatically with regression of neovascularization and improvement of corneal transparency and vision.</p><p><strong>Discussion: </strong>The present report described an atypical presentation of HPV-related OSSN due to its unusual morphology, young age of onset and absence of associated comorbidity.</p><p><strong>Conclusion: </strong>Conservative treatment with topical interferon-alpha 2b could be used to treat successfully HPV-16 positive OSSN, with no corneal irregularity or potential loss of vision compared to surgical excision.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11402260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Optical coherence tomography angiography reveals macular microvascular changes in myopic adolescents following orthokeratology lens wear.","authors":"Yali Zhou, Wenlei Yang, Yikang Dai","doi":"10.1177/11206721241260456","DOIUrl":"10.1177/11206721241260456","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the 6-month effects of wearing orthokeratology (OK) lenses on the retina vessel density (VD), vessel diameter index (VDI), and foveal avascular zone (FAZ) of myopia children using optical coherence tomography angiography, and to further investigate the underlying mechanisms of Orthokeratology in myopia control.</p><p><strong>Methods: </strong>Sixty-two eyes form 62 subjects were included in the study. Baseline and 6-month measurements of axial length (AL), anterior chamber depth (ACD), FAZ area, FAZ perimeter, FAZ circularity, vessel density (VD) and VDI from both the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were obtained.</p><p><strong>Results: </strong>The mean age of the participants was 11.02 years (range: 8 years to 15 years), with 41.9% males and 58.1% females. Six months after orthokeratology, ACD decreased significantly, and AL remain unchanged. SCP-VD and DCP-VD significantly increased after treatment without obvious change of VDI, and FAZ parameters remained unchanged. During follow-up period, SCP-VD increased in all subgroups especially in mild myopia group, and DCP-VD increased significantly in all subgroups except for the group 8-10 years.</p><p><strong>Conclusion: </strong>After the 6-month treatment of orthokeratology in myopia children, the macular microvasculature changed significantly. We observed a significant increase of vessel densities in both SCP and DCP without obvious effect on vascular morphology. The changes of DCP-VD tended to be more sensitive in the elder subgroup, and the efficacy of orthokeratology might be greater in mild myopia group. OCT-A may provide additional information on myopia progression and the mechanisms of controlling myopia with OK lens treatment.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Romero-Valero, Alicia Cárceles, Jorge L Alió, Carlos E Monera Lucas, Alejandro Moya Martínez, Jose Juan Martínez-Toldos
{"title":"Evaluation of 9 IOL power calculation formulas using a heteroscedastic statistical method and a new method of IOL constant optimization.","authors":"Daniel Romero-Valero, Alicia Cárceles, Jorge L Alió, Carlos E Monera Lucas, Alejandro Moya Martínez, Jose Juan Martínez-Toldos","doi":"10.1177/11206721241230347","DOIUrl":"10.1177/11206721241230347","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the prediction accuracy of 9 IOL power calculation formulas using a heteroscedastic statistical analysis and a novel method for IOL constant optimization.</p><p><strong>Design: </strong>Retrospective case series.</p><p><strong>Methods: </strong>The LenStar LS900 (Haag-Streit, Koeniz, Switzerland) was used for the preoperative biometry. The predicted SE refraction of the implanted IOL were calculated for: Barrett Universal II, EVO-2.0, Hill RBF-3.0, Hill-RBF 2.0, Kane, PEARL-DGS, SRK-T, Hoffer-Q and Holladay-1. IOL constants were optimized prior to the analysis. A heteroscedastic statistical method was used to compare the standard deviation (SD) of prediction errors (PE).</p><p><strong>Results: </strong>Two hundred seventy-eight eyes of 278 patients were included. The SD of the Kane was 0.4214D and was the lowest in this database. The SD of the PE of the Kane and EVO 2.0 were significantly lower than the SRK-T, Holladay 1, and Hoffer-Q. The SD of the PE of the PEARL formula was significantly lower than the SRK-T and Hoffer-Q. The SD of the PE of the Hill-RBF 3.0 was not significantly different to the Hill-RBF 2.0, Kane, EVO 2.0, Barrett Universal II and PEARL. No significant difference was found between the SD of the PE of the new generation formulas analysed.</p><p><strong>Conclusions: </strong>the lowest SD of the prediction error was provided by Kane, followed by EVO 2.0 and PERL-DGS formulas. However, no statistically significant differences were found between the SD of the PE of new generation formulas. Further studies are necessary to evaluate the accuracy of these formulas in extreme eyes.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139697223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}