{"title":"Effect of topical 0.01% atropine on myopia progression in Turkish children according to age and sex.","authors":"Erdi Karadağ, Nesrin Tutaş Günaydın","doi":"10.1177/11206721251377110","DOIUrl":"https://doi.org/10.1177/11206721251377110","url":null,"abstract":"<p><p>PurposeTo assess the effect of 0.01% atropine on myopia progression, considering age and sex differences.MethodsIn this prospective study, 51 participants were enrolled in the atropine group and 48 in the control group. One in the atropine group discontinued due to allergic conjunctivitis, leaving 50 for analysis. Participants were aged 6-16 years, with a mean age of 11.1 ± 2.6 years (atropine) and 10.9 ± 2.3 years (control), and had myopia between -2.00 and -6.00 D. Subjects were categorized by age (6-9, 10-12, 13-16 years) and sex. Spherical equivalent (SE), axial length (AL, via biometry), simulated keratometry (SimK) (via topography), and pupil diameter (via topography) were measured at baseline and at 1, 3, 6, and 12 months.ResultsBaseline characteristics did not differ significantly between groups (<i>p</i> > .05). SE progression at 12 months was significantly lower in the atropine group (-0.16 ± 0.35 D) than in controls (-0.31 ± 0.35 D; <i>p</i> = .041). AL increase was significant at 6 months in the atropine group (0.1 ± 0.23 mm, <i>p</i> = .003) and at 12 months in both groups (atropine: 0.26 ± 0.33 mm, <i>p</i> < .001; control: 0.37 ± 0.7 mm, <i>p</i> = .001). Pupil diameter and SimK changes were more pronounced in the atropine group (<i>p</i> < .05).ConclusionTopical 0.01% atropine slows myopia progression, especially in older children. Higher doses may be more effective for younger children and females.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251377110"},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraocular lens power calculation formulas in 674 cataract eyes after radial keratotomy: Bayesian network meta-analysis.","authors":"Zhao-Xing Guo, Meng Li, Jing-Shang Zhang, Ying-Yan Mao, Zhi-Yong Tian, Xin Zheng, Xiu-Hua Wan","doi":"10.1177/11206721251374370","DOIUrl":"https://doi.org/10.1177/11206721251374370","url":null,"abstract":"<p><p>ObjectiveTo analyze and compare the accuracy of different intraocular lens power calculation formulas in patients with cataract after radial keratotomy.MethodsWeb of Science, Cochrane Library, EMBASE and PubMed were searched for clinical studies published from the establishment of the database to 10th May 2024. Measurements were taken as percentage of eyes of prediction errors within ±0.5 D and ±1.0 D. A network meta-analysis was utilized to compare the different formulas as a way to identify the most advantageous ones.ResultsResults from 11 studies of 674 eyes after radial keratotomy that used 24 formulas were included. A network meta-analysis indicated that <b>for error within the range of ± 0.5 D,</b> Barrett true-K History and Barrett true-K Partial History were better than Double-K Holladay 1. Intraoperative Aberrometry, Double-K SRK/T, Haigis and Barrett true-K No History performed as well or better than Double-K Holladay 1. Shammas No History and Holladay 1 had poor performance. <b>For error within the range of ±1.0 D,</b> Shammas No History and Barrett Universal II had poor performance. No statistically significant difference was observed between the other formulas.ConclusionsFor cataract patients after radial keratotomy, Barrett true-K History and Barrett true-K Partial History were recommended if the prior medical history were available. Otherwise, no single formula is more advantageous without reference to prior medical history.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251374370"},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdelrahman Assaf, Fidan A Aghayeva, Tatiana Sykorova, Ines Lanzl
{"title":"Clinical efficacy of two modalities of selective laser trabeculoplasty in the treatment of primary open-angle glaucoma.","authors":"Abdelrahman Assaf, Fidan A Aghayeva, Tatiana Sykorova, Ines Lanzl","doi":"10.1177/11206721251372801","DOIUrl":"https://doi.org/10.1177/11206721251372801","url":null,"abstract":"<p><p>PurposeTo evaluate clinical outcomes of two selective laser trabeculoplasty (SLT) approaches in the management of primary open-angle glaucoma (POAG): a single-session 180° SLT versus a staggered 360° SLT approach, where a second 180° treatment was added to the superior trabecular meshwork 1-2 months after the initial inferior treatment.MethodsA retrospective chart review was conducted on 134 eyes of 134 patients with POAG treated at a single center. Sixty-seven eyes received only 180° SLT, while 67 underwent staggered 360° SLT. The decision to proceed with the second session was based on clinician judgment and was not standardized. Intraocular pressure (IOP) and the number of topical IOP-lowering medications were assessed at baseline, and at 3, 6, and 12 months post-treatment.ResultsBoth groups showed significant IOP reduction at all follow-up visits (p < 0.001). At 12 months, the mean IOP change was -5.1 ± 3.3 mmHg (180° SLT) and -4.9 ± 3.5 mmHg (360° SLT). Higher baseline IOP was associated with greater IOP reduction (p < 0.001). No statistically significant difference in IOP-lowering efficacy was observed between groups. However, the 360° SLT group showed a greater within-group reduction in medication burden (p < 0.01) compared to the 180° group (p < 0.05).ConclusionsBoth 180° and staggered 360° SLT were effective in lowering IOP in POAG patients. While limited by its retrospective design and selection bias, this study supports staggered SLT as a viable strategy to reduce medication dependency in clinical practice.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251372801"},"PeriodicalIF":1.4,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matteo Menean, Nicolò Nicolini, Luca Cimino, Francesco Bandello, Elisabetta Miserocchi
{"title":"Chronic necrotizing sclerouveitis caused by Alternaria doliconidium.","authors":"Matteo Menean, Nicolò Nicolini, Luca Cimino, Francesco Bandello, Elisabetta Miserocchi","doi":"10.1177/11206721251369539","DOIUrl":"https://doi.org/10.1177/11206721251369539","url":null,"abstract":"<p><p>PurposeTo report a case of fungal sclerouveitis caused by <i>Alternaria doliconidium</i>, misdiagnosed as autoimmune scleritis and incorrectly treated with immunosuppressive therapy.ObservationsA 69-year-old man presented with progressive chronic necrotizing scleritis in his right eye following ocular trauma. Initial treatment with antimicrobial and steroid therapy showed no improvement, and a scleral biopsy yielded inconclusive results. Autoimmune scleritis was suspected, leading to treatment with systemic steroids and immunosuppressants. Upon further examination, nodular necrotizing scleritis with scleral translucency and whitish floccules in the anterior chamber was observed, prompting a suspicion of fungal etiology. Molecular analysis via PCR confirmed the presence of <i>Alternaria doliconidium</i>.Conclusions and ImportanceThis case underscores the importance of considering fungal pathogens in cases unresponsive to conventional treatment and the critical role of advanced molecular diagnostics. This is the first reported case of sclerouveitis caused by <i>Alternaria doliconidium</i>, expanding the spectrum of ocular infections associated with this genus.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251369539"},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Niroj Kumar Sahoo, Rajan Alagar, Selina Chang, Arman Zarnegar, Ashika Patil, Rubble Mangla, Ramesh Venkatesh, Federico Ricardi, Michele Reibaldi, Enrico Borrelli, Lucas Zago Ribeiro, Luiz H Lima, Antonio Marcelo Casella, Dmitrii S Maltsev, Antonio Domingo Alarcon-Garcia, Jose Ignacio Fernandez-Vigo, Giulia Corradetti, Jay Chhablani
{"title":"Clinical and imaging characteristics of central serous chorioretinopathy with subfoveal leak.","authors":"Niroj Kumar Sahoo, Rajan Alagar, Selina Chang, Arman Zarnegar, Ashika Patil, Rubble Mangla, Ramesh Venkatesh, Federico Ricardi, Michele Reibaldi, Enrico Borrelli, Lucas Zago Ribeiro, Luiz H Lima, Antonio Marcelo Casella, Dmitrii S Maltsev, Antonio Domingo Alarcon-Garcia, Jose Ignacio Fernandez-Vigo, Giulia Corradetti, Jay Chhablani","doi":"10.1177/11206721251378338","DOIUrl":"10.1177/11206721251378338","url":null,"abstract":"<p><p>PurposeTo define the clinical characteristics and to analyse the factors predicting visual acuity in eyes with central serous chorioretinopathy (CSCR) with subfoveal leak.MethodsThis was a multicentric, retrospective, observational comparison of CSCR eyes with subfoveal versus extrafoveal leak, with secondary analysis identifying predictors of 12-month best corrected visual acuity (BCVA) within the subfoveal group.ResultsA total of 134 eyes of 134 patients (113 males and 21 females) with a mean age of 49.6 ± 11.1 years, were included. The median duration of symptoms before presentation was two months. The leak was subfoveal in 50 eyes and extrafoveal in 84 eyes. The duration of symptoms was significantly higher in eyes with extrafoveal leak, than subfoveal leak group (p = 0.01). Eyes with subfoveal leak had higher Haller vessel/choroidal thickness ratio at fovea at baseline. BCVA at one year was similar in both cohorts. On linear regression analysis, factors affecting poor visual acuity at 1 year in eyes with subfoveal leak were greater duration of symptoms, complex CSCR at presentation, history of persistence/recurrences, higher number of leaks, focal retinal pigment epithelium (RPE) atrophy areas, and more months waited before treatment initiation.ConclusionsPatients with CSCR and subfoveal leaks presented earlier and showed a higher baseline Haller to choroidal thickness ratio at the fovea than those without. Although 1-year visual outcomes were similar to extrafoveal leaks, worse BCVA in the subfoveal leak group was associated with complex, persistent or recurrent disease, focal RPE atrophy, longer symptom duration, multiple leaks, and delayed treatment initiation.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251378338"},"PeriodicalIF":1.4,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Obeda Kailani, Sameh Mosaed, Fritz H Hengerer, Rachana Patel, Anna W Świder, Federico Ghinelli, Laura Wells, Patricia Buchholz
{"title":"Systematic review and meta-analysis of the clinical effectiveness, safety, humanistic and economic burden of the OMNI<sup>®</sup> surgical system and its predecessors.","authors":"Obeda Kailani, Sameh Mosaed, Fritz H Hengerer, Rachana Patel, Anna W Świder, Federico Ghinelli, Laura Wells, Patricia Buchholz","doi":"10.1177/11206721251376889","DOIUrl":"https://doi.org/10.1177/11206721251376889","url":null,"abstract":"<p><p>ObjectiveThe aim of this systematic review and meta-analysis was to assess the clinical, humanistic, and economic evidence of the OMNI<sup>®</sup> Surgical System (OMNI), Visco360 and Trab360 for open-angle glaucoma (OAG).MethodsSearch strategies were applied across MEDLINE<sup>®</sup>, Web of Science™, Cochrane (January 2016-April 2024) on 16th April 2024. Congress proceedings (2021-2024) were searched in July 2024. Studies containing ≥15 patients that reported clinical, humanistic or economic outcomes associated with the use of OMNI, Visco360 or Trab360 for the treatment of adults with OAG were included. Structured summaries were used to summarize findings and a meta-analysis synthesized the data. Risk of bias was assessed using the Newcastle-Ottawa and CHEERS checklists. The protocol was registered on PROSPERO (CRD42024536680).ResultsAmong 29 included publications, 27 reported clinical and 2 reported economic outcomes. OMNI significantly reduced intraocular pressure (IOP) with mean IOP <18 mmHg (11.5-17.2 mmHg) at 12 months when used standalone or combined with cataract surgery. The meta-analysis confirmed statistically significant, comparable IOP reductions at months 6, 12 and 24. IOP-lowering medication use decreased from 0.9-3.4 at baseline to 0.1-2.2 at month 12 (standalone and combination)<b>;</b> these continued months 24-36. Adverse events were generally mild and transient.ConclusionOMNI consistently reduced IOP and medication use demonstrating sustained effects over 24--36 months with a favorable safety profile, thus supporting its use in patients with OAG. Limitations of this review include the absence of randomized controlled trials. Six studies were assessed as good quality, the remainder showed risk of bias.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251376889"},"PeriodicalIF":1.4,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi
{"title":"The performance of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 in reducing conjunctival bacterial load in patients receiving cataract surgery, a randomized trial.","authors":"Alessio Martucci, Elisa Zanotto, Antonio Curtoni, Alessandro Tiezzi Appolloni, Andrea Corsi","doi":"10.1177/11206721251375236","DOIUrl":"https://doi.org/10.1177/11206721251375236","url":null,"abstract":"<p><p>PurposeTo evaluate the safety and ability of an ophthalmic solution containing Poloxamer 407 and Polyquaternium 133 to reduce conjunctival bacterial load before cataract surgery.MethodsPatients (n = 74) were randomized to 2 groups: treatment (n = 37) or placebo (treatment's vehicle; (n = 37)) BID from V1 to V3. Patients were also given standard postoperative treatment from V2 to V3. Patients underwent ophthalmological examination, eye swabs, Break Up time (BUT), Ocular Surface Disease Index (OSDI), Oxford Scale and conjunctival hyperemia grading at V1 (day -3 from surgery), V2 (day 0, surgery), and V3 (day +7 from surgery). Overall subjective experience using the investigated ophthalmic solution and burning sensation were evaluated using Likert and VAS scales. Wilcoxon test, paired T-test and zero-inflated negative binomial models, were used when appropriate. A p ≤ 0,05 was considered significant. ClinicalTrials.gov identifier: NCT06533995.ResultsIntergroup analysis showed a significantly reduced bacterial load in treated comparing V2 vs V1 (p = 0,002) and V3 vs V1 (p = 0,0007). No differences were found in the controls. Zero-inflated negative binomial models were estimated: V2 Odds Ratio 0,44 (0,20; 0,98) p = 0,044, and V3 Odds Ratio 0,72 (0,12; 4,21) p = 0,71 in the treated. No significant differences between groups were found considering: BUT, OSDI, hyperemia, Oxford Score, subjective experience and burning.ConclusionsThe ophthalmic solution was tolerated and reduced, at all-time points, the bacterial load in the treated group. On the surgery day, the latter had a significantly reduced bacterial load than controls. Thus, suggesting the usefulness of the ophthalmic solution as an add-on therapy to reduce conjunctival bacterial load before cataract surgery.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251375236"},"PeriodicalIF":1.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Caruso, Francesco Cappellani, Margherita Stefania Rodolico, Roberta Amato, Giuseppe Brischetto, Valeria Steccanella, Caterina Gagliano, Giovanni Rubegni, Massimiliano Salfi
{"title":"A 3D-printed portable slit lamp for high-resolution anterior segment images.","authors":"Andrea Caruso, Francesco Cappellani, Margherita Stefania Rodolico, Roberta Amato, Giuseppe Brischetto, Valeria Steccanella, Caterina Gagliano, Giovanni Rubegni, Massimiliano Salfi","doi":"10.1177/11206721251375142","DOIUrl":"https://doi.org/10.1177/11206721251375142","url":null,"abstract":"<p><p>PurposeTo introduce, describe and validate a novel, 3D-printed portable slit lamp system integrated with a macro lens-equipped smartphone, providing clinicians with a quick, easy, and effective method for obtaining high-quality clinical images.Materials and MethodsA 3D-printed portable slit lamp was developed, comprising a warm white LED light pen housed in a custom case with a biconvex lens focusing light through a 0.4 mm slit. A high-end smartphone equipped with a 100 mm macro lens served as the imaging device. Thirteen patients with various ocular conditions were examined using both the portable slit lamp and a conventional slit lamp. Three ophthalmology specialists, each with at least 3 years of experience, evaluated 26 images to assess the image quality and diagnostic efficiency using a Likert scale from 1 to 5. At the end of the evaluation, they rated the ease of use of the device in obtaining clinical images of the anterior segment, using a Likert scale from 1 to 4.ResultsData on quality perception and diagnostic efficiency demonstrated high values comparable to those obtained with the conventional slit lamp. The specialists rated the image quality with mean scores of 4.54, 4.46, and 4.31, and diagnostic efficiency with mean scores of 4.62, 4.69, and 4.38. The device was also found to be very user-friendly, receiving scores of 4, 4, and 3.ConclusionOur 3D-printed portable slit lamp system, coupled with a modern smartphone, effectively captured high-resolution images of the anterior segment in an easy and inexpensive way.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251375142"},"PeriodicalIF":1.4,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to Clinical evaluation of tear substitute utility after anti-VEGF intravitreal injection.","authors":"","doi":"10.1177/11206721251376824","DOIUrl":"https://doi.org/10.1177/11206721251376824","url":null,"abstract":"","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251376824"},"PeriodicalIF":1.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}