European Journal of Ophthalmology最新文献

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Can machines see cancer? A systematic review and diagnostic meta-analysis of machine learning in retinoblastoma and leukocoria detection. 机器能看到癌症吗?机器学习在视网膜母细胞瘤和白斑检测中的系统回顾和诊断荟萃分析。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-05 DOI: 10.1177/11206721251375239
Paweł Marek Łajczak, Przemysław Nowakowski, Kamil Jóźwik, Krzysztof Żerdziński, Julita Janiec
{"title":"Can machines see cancer? A systematic review and diagnostic meta-analysis of machine learning in retinoblastoma and leukocoria detection.","authors":"Paweł Marek Łajczak, Przemysław Nowakowski, Kamil Jóźwik, Krzysztof Żerdziński, Julita Janiec","doi":"10.1177/11206721251375239","DOIUrl":"https://doi.org/10.1177/11206721251375239","url":null,"abstract":"<p><p>There is a growing interest in the use of machine learning (ML) for the diagnosis of retinoblastoma and leukocoria, and this study aims to systematically evaluate its performance compared with reference standards. A systematic review and meta-analysis were performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We included studies using ML to diagnose retinoblastoma or leukocoria and providing enough data for analysis of diagnostic accuracy. We calculated sensitivity, specificity, and other measures of diagnostic performance. Twelve studies were included. Pooled sensitivity for retinoblastoma and leukocoria detection was 0.972 with ML models, indicating high potential for screening. However, high heterogeneity in the analyses was observed. The review also noted biases in some studies, along with small sample sizes that would limit generalizability. ML models appear to be promising for retinoblastoma diagnosis; however, limitations in specificity and potential methodological bias need further investigation. Incorporating research that used photographs taken with smartphone cameras indicates that ML-based diagnosis may become even more widely available through the use of such technology. Future studies need to have better specificity of the model, less bias in the methodology, must be conducted on large-scale datasets and they should address the cost-effective analysis compared with traditional methods. The incorporation of ML into the practice of retinoblastoma diagnosis has the capacity to transform the mode of detecting this condition and ultimately enhance patient management.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251375239"},"PeriodicalIF":1.4,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145000074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characteristics of tear meniscus, punctum, and cornea epithelium using an anterior segment optical coherence tomography in glaucoma. 青光眼前段光学相干断层扫描观察半月板、泪点和角膜上皮的特征。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-04 DOI: 10.1177/11206721251374170
Neslihan Sevimli, Banu Açıkalın, Cansu Selen Çıplakkılıç, Gülden Çağlar, Abdulkadir Küçük, Cihan Kerekli
{"title":"Characteristics of tear meniscus, punctum, and cornea epithelium using an anterior segment optical coherence tomography in glaucoma.","authors":"Neslihan Sevimli, Banu Açıkalın, Cansu Selen Çıplakkılıç, Gülden Çağlar, Abdulkadir Küçük, Cihan Kerekli","doi":"10.1177/11206721251374170","DOIUrl":"https://doi.org/10.1177/11206721251374170","url":null,"abstract":"<p><p>PurposeTo investigate the differences in punctal dimensions, tear meniscus height (TMH), and cornea epithelium among medically controlled glaucoma patients using anterior segment optical coherence tomography (AS-OCT) and evaluate the parameters that affect the results.MethodsThis cross-sectional, observational study included 80 subjects with primary open-angle glaucoma and 80 normal subjects without glaucoma and ocular symptoms. AS-OCT was used to measure TMH, outer punctal diameter (OPD), punctal depth (PD), and central corneal epithelial thickness (CCET). Correlations for the effect of topical anti-glaucoma medications on OPD, PD, TMH, and CCET were analyzed. The impact of prostaglandin analogs (PGAs) and Beta-blockers on the parameters were evaluated.ResultsNo significant differences were found in age and sex between the groups (<i>p</i> = 0.333 and <i>p</i> = 0.635, respectively). Glaucoma patients exhibited significantly narrower OPD (<i>p</i> < 0.001), TMH (<i>p</i> < 0.001), and CCET (<i>p</i> = 0.006). Subjects on longer-duration therapy showed a statistically significant reduction in TMH and CCET (<i>p</i> < 0.001 and <i>p</i> = 0.022). While the PD value was significantly lower in those using anti-glaucoma medications containing Beta-blockers (<i>p</i> = 0.002), the TMH value was significantly lower in those containing PGAs (<i>p</i> = <i>0.037</i>).ConclusionsTopical anti-glaucoma medications affect the OPD, TMH, and CCET in glaucoma patients compared with normal subjects. Topical anti-glaucoma medications usage duration has negative effects on TMH and CCET. Beta-blockers are more effective on the punctum, while PGAs are more effective on the TMH. These findings highlight the utility of AS-OCT in assessing asymptomatic glaucoma patients and its effects on the ocular surface.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251374170"},"PeriodicalIF":1.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous retinal reattachment and novel vitreoretinal phenotype in muscle eye brain disease determined by fundus multimodal imaging. 眼底多模态成像确定的肌眼脑病自发性视网膜再附着和新的玻璃体视网膜表型。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-04 DOI: 10.1177/11206721251375233
Evita Evangelia Christou, Ravi Purohit, Alice Di Domenico, Peter Charbel Issa, C K Patel
{"title":"Spontaneous retinal reattachment and novel vitreoretinal phenotype in muscle eye brain disease determined by fundus multimodal imaging.","authors":"Evita Evangelia Christou, Ravi Purohit, Alice Di Domenico, Peter Charbel Issa, C K Patel","doi":"10.1177/11206721251375233","DOIUrl":"https://doi.org/10.1177/11206721251375233","url":null,"abstract":"<p><p>IntroductionMuscle eye brain disease (MEB) is a rare, multi-systemic autosomal recessively inherited disorder of relevance to ophthalmologists. The aim of this report is to describe a novel ocular phenotype for a genetically confirmed MEB patient using retinal multi-modal imaging.Case descriptionWe report a case of 18-year-old male patient that was referred to our tertiary unit for management of retinal detachment. Fundoscopic examination indicated optic nerve and macula hypoplasia, retinal hypo-pigmentation, and unilateral retinal detachment. There were no retinal breaks found in association with retinal detachment affecting the left eye. A well demarcated temporal pigmentary retinopathy with a 'ghost' retinal vessel in fundus autofluorescence image suggested spontaneous retinal reattachment of the retina in the right eye. Fundus autofluorescence and optical coherence tomography images revealed the novel features of internal limiting membrane disruption and sub-retinal opacity in association with neurosensory separation of the left retina, which is consistent with histopathology in the human eye and the mouse models of the disease.ConclusionsOur case suggests that retinal detachment in MEB disease should be managed conservatively in the absence of retinal breaks as spontaneous reattachment can occur. Extensive areas of non-perfusion should be treated with laser photo-coagulation to avoid the sequelae of retinal neovascularization. The mechanism for the development of retinal detachment without breaks is unknown.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251375233"},"PeriodicalIF":1.4,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A randomized controlled trial of symmetric versus asymmetric intrastromal corneal ring segments for asymmetric keratoconus. 对称与非对称角膜间环段治疗非对称圆锥角膜的随机对照试验。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-02 DOI: 10.1177/11206721251372378
Belquiz Amaral Nassaralla, Jordana Sandes Barbosa Soares, Mauro Campos
{"title":"A randomized controlled trial of symmetric versus asymmetric intrastromal corneal ring segments for asymmetric keratoconus.","authors":"Belquiz Amaral Nassaralla, Jordana Sandes Barbosa Soares, Mauro Campos","doi":"10.1177/11206721251372378","DOIUrl":"https://doi.org/10.1177/11206721251372378","url":null,"abstract":"<p><p>PurposeThis study evaluated the safety and effectiveness of two models of intrastromal corneal ring segments (ICRS)-symmetric (uniform thickness and base width) and asymmetric (progressive thickness and base width)-for the treatment of oval phenotype keratoconus.MethodsA prospective, randomized, controlled clinical study was conducted on 64 eyes from 47 patients, divided into two groups: Group 1 (33 eyes) received symmetric ICRS, and Group 2 (31 eyes) received asymmetric ICRS. Comprehensive ophthalmic evaluations, including visual acuity, corneal topography, tomography, and aberrometry, were performed preoperatively and at 1, 3, 6, and 12 months postoperatively.ResultsAt 12 months, Group 2 demonstrated significantly greater reductions in K1, Km, Kmax, asphericity, vertical coma and spherical aberration, and most topographic indices compared to Group 1. Best-corrected visual acuity was higher in Group 2, reaching statistical significance at 6 months. No implant-related complications were observed in either group.ConclusionsAsymmetric ICRS provided superior topographic, tomographic, and aberrometric outcomes compared to symmetric ICRS in the treatment of asymmetric keratoconus, leading to greater improvements in corneal regularity, asphericity, and cone inclination.<b>Clinical Trial Registration:</b> This study was registered with the National Research Ethics Commission (CONEP) under registration number 32212020.9.0000.5505.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251372378"},"PeriodicalIF":1.4,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence and risk factors of anxiety and depression in diabetic retinopathy patients: A cross-sectional study using multiple scales. 糖尿病视网膜病变患者焦虑和抑郁的患病率及风险因素:一项使用多种量表的横断面研究。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2024-11-20 DOI: 10.1177/11206721241300213
Hui Qiu
{"title":"Prevalence and risk factors of anxiety and depression in diabetic retinopathy patients: A cross-sectional study using multiple scales.","authors":"Hui Qiu","doi":"10.1177/11206721241300213","DOIUrl":"10.1177/11206721241300213","url":null,"abstract":"<p><p>ObjectiveTo investigate the prevalence of anxiety and depression, and explore their related factors in all types of diabetic retinopathy (DR) patients more precisely and accurately by multiple scales.MethodsBeck anxiety inventory (BAI), self-rating anxiety scale (SAS), beck depression inventory (BDI), and self-rating depression scale (SDS) scores were assessed in 247 DR patients and 250 non-retinopathic diabetes mellitus (NRDM) patients.ResultsIn DR patients, there were 32 patients with proliferative DR and 115 patients with impaired visual acuity. The prevalences (95% confidence interval) of anxiety were 38.5% (32.4%-44.6%) and 32.0% (26.2%-37.8%) by BAI and SAS, while those for depression were 31.6% (25.8%-37.4%) and 25.1% (19.7%-30.5%) by BDI and SDS in DR patients. BAI score (<i>P </i>= 0.003), BAI-defined anxiety rate (<i>P </i>= 0.010), SAS score (<i>P </i>= 0.001), SAS-defined anxiety rate (<i>P </i>= 0.006), BDI score (<i>P </i>= 0.005), BDI-defined depression rate (<i>P </i>= 0.028), and SDS score (<i>P </i>= 0.001) were increased in DR patients versus NRDM patients. In DR patients, proliferative DR independently related to BAI-defined anxiety (<i>P </i>< 0.001) and SAS-defined anxiety (<i>P </i>< 0.001). Female (<i>P </i>= 0.016) and proliferative DR (<i>P </i>< 0.001) independently associated with BDI-defined depression; female (<i>P </i>= 0.007), DM duration (<i>P </i>= 0.025), triglyceride (TG) (<i>P </i>= 0.026), and proliferative DR (<i>P </i>= 0.014) independently associated with SDS-defined depression. The combination of these independent factors showed acceptable abilities in predicting BAI-defined anxiety, SAS-defined anxiety, BDI-defined depression, or SDS-defined depression in DR patients, with area under curves of 0.626, 0.656, 0.696, and 0.741, respectively (all <i>P </i>< 0.001).ConclusionAnxiety and depression are prevalent; meanwhile, proliferative DR, female, DM duration, and TG independently relate to anxiety or depression in DR patients.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1728-1737"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toward comprehending uncommon periocular manifestations: A case of localized AL amyloidosis with a rare spontaneous eyelid ecchymosis. 了解罕见的眼周表现:局限性AL淀粉样变合并罕见的自发性眼睑瘀斑1例。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-22 DOI: 10.1177/11206721251333603
Caio Brenno Abreu, Bárbara Flores Culau Merlo, Márcio Penha Morterá Rodrigues, Fernanda Galante Dourado, Tullia Cuzzi Teichner, Danielle Carvalho Quintella, Denize D'Azambuja Ramos, Juliana de Sá Freire Medrado Dias
{"title":"Toward comprehending uncommon periocular manifestations: A case of localized AL amyloidosis with a rare spontaneous eyelid ecchymosis.","authors":"Caio Brenno Abreu, Bárbara Flores Culau Merlo, Márcio Penha Morterá Rodrigues, Fernanda Galante Dourado, Tullia Cuzzi Teichner, Danielle Carvalho Quintella, Denize D'Azambuja Ramos, Juliana de Sá Freire Medrado Dias","doi":"10.1177/11206721251333603","DOIUrl":"10.1177/11206721251333603","url":null,"abstract":"<p><p>IntroductionAmyloidosis, characterized by extracellular protein misfolding and deposition. Localized immunoglobulin light chain amyloidosis can present with atypical features.Case presentationThis case report elucidates an unconventional manifestation of localized immunoglobulin light chain amyloidosis characterized by recurrent and spontaneous eyelid ecchymosis alternating with episodes of incomplete resolution, a novelty in current literature, along with associated cutaneous changes.DiscussionThis rare presentation underscores the importance of considering amyloidosis in the differential diagnosis of unusual periocular findings and may assist in identifying similar cases of atypical eyelid amyloidosis, especially in cases with limited involvement, promoting early diagnosis and intervention.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP53-NP58"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing potential biomarkers for early detection of retinal changes in Parkinson's disease: Preliminary study on BDNF role. 实现潜在的生物标志物早期检测帕金森病视网膜变化:BDNF作用的初步研究。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-17 DOI: 10.1177/11206721251335060
Mariaelena Malvasi, Esterina Pascale, Nicoletta Locuratolo, Francesco Fattapposta, Caterina Pauletti, Maria Grazia Finoia, Marcelo Enrique Conti, Elena Pacella
{"title":"Implementing potential biomarkers for early detection of retinal changes in Parkinson's disease: Preliminary study on BDNF role.","authors":"Mariaelena Malvasi, Esterina Pascale, Nicoletta Locuratolo, Francesco Fattapposta, Caterina Pauletti, Maria Grazia Finoia, Marcelo Enrique Conti, Elena Pacella","doi":"10.1177/11206721251335060","DOIUrl":"10.1177/11206721251335060","url":null,"abstract":"<p><p>BackgroundVisual dysfunctions in Parkinson's disease (PD) patients suggest a possible degeneration of dopaminergic retinal layers, This study aimed to investigate macular retinal thickness in PD patients versus healthy controls using Optical Coherence Tomography (OCT), a non-invasive technique for in vivo retinal imaging. The role of the Val66Met polymorphism in the BDNF gene in relation to retinal degeneration and clinical features of PD was also explored.MethodsThis case-control study included 26 patients with idiopathic PD and 78 age- and sex-matched healthy controls, for a total of 208 eyes. All subjects underwent a 512 × 496-line OCT volumetric scan centred on the macular region.ResultsMacular thickness was measured in each sector and as an average across 360°. Significant differences were found in the superior sector of the left eye (OS2) (increase of 3 units in PD), the inferior sector of the left eye (OS2) (decrease of 3 units in PD), and the total volume of both eyes (decrease of 0.13 units in PD). An inverse correlation between retinal thickness and age at onset was observed in the temporal and inferior sectors of both eyes. The Val/Met heterozygous polymorphism was identified in 30.7% of PD patients.ConclusionsThe study confirms that thinning of the inner retinal layers is associated with PD. OCT provides a rapid, non-invasive, repeatable, and cost-effective method for in vivo assessment of retinal layers, supporting its potential as an early biomarker for PD. Further longitudinal studies with larger samples are needed to clarify the role of the BDNF polymorphism in retinal degeneration in PD.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1746-1760"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vitro and in vivo antimicrobial activity of medicated wipes containing biosecur on the microbial Flora of the eyelid and conjunctiva. 含生物安全剂药物湿巾对眼睑和结膜微生物菌群的体内外抗菌活性。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-15 DOI: 10.1177/11206721251332758
Giuseppe Giannaccare, Aldo Vagge, Marco Pellegrini, Matilde Buzzi, Rita Mencucci, Massimo Lorusso, Mariacristina Massimino, Costanza Rossi, Francesco Celandroni, Marco Calvigioni, Diletta Mazzantini, Massimo Nicolò, Vincenzo Scorcia, Carlo E Traverso, Emilia Ghelardi
{"title":"<i>In vitro</i> and <i>in vivo</i> antimicrobial activity of medicated wipes containing biosecur on the microbial Flora of the eyelid and conjunctiva.","authors":"Giuseppe Giannaccare, Aldo Vagge, Marco Pellegrini, Matilde Buzzi, Rita Mencucci, Massimo Lorusso, Mariacristina Massimino, Costanza Rossi, Francesco Celandroni, Marco Calvigioni, Diletta Mazzantini, Massimo Nicolò, Vincenzo Scorcia, Carlo E Traverso, Emilia Ghelardi","doi":"10.1177/11206721251332758","DOIUrl":"10.1177/11206721251332758","url":null,"abstract":"<p><p>PurposeTo evaluate the <i>in vitro</i> and <i>in vivo</i> antimicrobial activity on the microbial flora of the eyelids and conjunctiva of the new medicated wipes LENIVA bio, soaked with an antiseptic solution containing natural extracts from citrus fruits (Biosecur<sup>®</sup>), <i>Aloe vera</i>, and <i>Ruscus aculeatus</i>.MethodsThe <i>in vitro</i> antimicrobial activity of the LENIVA bio antiseptic solution against bacteria and fungi commonly found in the periocular area, including antibiotic-resistant strains, was measured by agar diffusion and microdilution assays. The <i>in vivo</i> activity was measured on swabs collected from the eyelid rim and conjunctiva of 20 patients (13 males, 7 females; mean age 70.5 years) before and after a 4-day treatment with the product. Contralateral untreated eyes were used as controls.ResultsThe <i>in vitro</i> analysis of inhibition halos in agar diffusion assays demonstrated that LENIVA bio is active against all tested germs, even when diluted. <i>In vivo</i>, the reduction in the total microbial counts obtained from both eyelid rim and conjunctival swabs following treatment with LENIVA bio wipes was statistically significant (respectively, mean reduction = 4530 CFU/ml, <i>p</i> < 0.0001; mean reduction = 893 CFU/ml, <i>p</i> = 0.0384).ConclusionLENIVA bio wipes showed <i>in vitro</i> and <i>in vivo</i> antimicrobial activity against microorganisms that are potential pathogens of the eye and/or commonly found in the periocular area.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1810-1817"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isotretinoin-related post-surgical interface alterations during sun light exposure: A case report. 异维甲酸相关的术后界面改变在阳光照射下:一个病例报告。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-29 DOI: 10.1177/11206721251337160
Sara Spelta, Antonio Di Zazzo, Mariateresa Laborante, Andrea De Luca, Vincenzo Barone, Marco Coassin
{"title":"Isotretinoin-related post-surgical interface alterations during sun light exposure: A case report.","authors":"Sara Spelta, Antonio Di Zazzo, Mariateresa Laborante, Andrea De Luca, Vincenzo Barone, Marco Coassin","doi":"10.1177/11206721251337160","DOIUrl":"10.1177/11206721251337160","url":null,"abstract":"<p><p>IntroductionRefractive surgery, including procedures like photorefractive keratectomy (PRK) and laser-assisted in situ keratomileusis (LASIK), is increasingly common and generally safe, offering favorable optical outcomes. However, patients' anamnesis often lacks significant clinical information, such as systemic treatments for acne, diabetes, and polycystic ovary syndrome. Isotretinoin, a systemic treatment for severe acne, is rarely associated with corneal abnormalities.Patient and Clinical FindingsThis case report presents a 26-year-old female who underwent PRK for her myopic refractive error in both eyes, without disclosing her systemic isotretinoin therapy.Diagnosis, Intervention, and OutcomesPost-surgery, she developed fine bilateral basal membrane irregularities and subepithelial interface alterations. Despite a change in topical therapy, subepithelial haze persisted but improved over time, achieving an uncorrected distance visual acuity of 20/20 in both eyes at 2.5 months from surgery.ConclusionsIsotretinoin can induce ocular surface changes, including corneal epithelial thickening and stromal thinning, dry eye symptoms, and conjunctival modifications. Concurrent UVB exposure during corneal healing can exacerbate these effects, causing metabolic activation, extracellular matrix production, and corneal thickening. This case report highlights the importance of deepened patient's anamnesis before refractive surgery and suggests further studies on the relative contraindication of perioperative isotretinoin.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP19-NP22"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building a strong European journal of ophthalmology. 建立一个强大的欧洲眼科杂志。
IF 1.4 4区 医学
European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-08-28 DOI: 10.1177/11206721251367117
Alessandro Rabiolo
{"title":"Building a strong European journal of ophthalmology.","authors":"Alessandro Rabiolo","doi":"10.1177/11206721251367117","DOIUrl":"https://doi.org/10.1177/11206721251367117","url":null,"abstract":"<p><p>Since January 2025, the European Journal of Ophthalmology has entered a phase of change aimed at strengthening its role as a platform for European researchers. We have restructured the editorial board into specialized sections, introduced new content areas focused on AI, public health, and evidence-based medicine, and we are replacing case reports with a new section dedicated to clinical images. We have also launched official social media accounts to share content more widely and are working on ways to better recognize the contributions of our reviewers. These changes reflect a long-term commitment to building a journal that represents and supports European ophthalmology on the global stage.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":"35 5","pages":"1525-1526"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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