European Journal of Ophthalmology最新文献

{"title":"A face-to-face survey on the practice of ophthalmic clinicians in the management of dry eye disease in patients undergoing cataract surgery.","authors":"Khayam Naderi, Laura Maubon, Chun Fung Jeffrey Lam, Harry Roberts, Vishal Shah, Darshak S Patel, David O'Brart","doi":"10.1177/11206721241312249","DOIUrl":"10.1177/11206721241312249","url":null,"abstract":"<p><p>IntroductionDry eye disease (DED) can impact the accuracy of biometry measurements prior to cataract surgery (CS), influence visual performance post-CS, and can be exacerbated by CS. We performed a survey to evaluate the DED practice of clinicians directly caring for CS patients.DesignProspective face-to-face survey.MethodFace-to-face survey consisting of 12 questions relating to CS clinicians' estimations of DED pre- and post-CS, dry eye tests performed, and the management of DED.ResultThere were one hundred and twenty-seven responders (39% consultants, 37% trainees/fellows, 8% associate specialists, 6% specialty doctors, 8% optometrists, 2% nurse specialists), with a 100% response rate. Sixty-seven percent routinely assessed for DED pre-CS, with 81% anticipating mild to moderative negative effects of CS on DED. Approximately 75% estimated that over 10% of pre-operative patients had asymptomatic DED, with another 10% or more suffering symptomatic DED. Almost 80% estimated that 10% or more of patients suffered DED post-CS. More DED tests were performed pre- compared to post-operatively (p = 0.02). More consultants performed dry eye tests post-operatively compared to non-consultants (p = 0.02). Most common treatment options included lubricating drops (95%), lid hygiene (75%) and night ointment/gels (54%). Seventy-six percent of surgeons performing CS stated they coated the ocular surface with an ophthalmic visco-surgical device and 34% limited intra-operative light exposure peri-operatively to limit DED.DiscussionDespite the anticipated negative effects of CS on DED, 1 in 3 clinicians in our survey were not assessing routinely for DED prior to CS, and fewer dry eye tests were performed post-operatively compared to pre-surgery.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1195-1202"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Face-up vs face-down positioning after rhegmatogenous macula-off retinal detachment surgery: Hypothesis of better recovery.","authors":"Alfonso Savastano, Valerio Calabresi, Emanuele Crincoli, Maria Cristina Savastano, Umberto De Vico Umberto, Nicola Claudio D'Onofrio, Stanislao Rizzo, Andrea Govetto","doi":"10.1177/11206721251318764","DOIUrl":"10.1177/11206721251318764","url":null,"abstract":"<p><p>PurposeTo evaluate the differences between two distinct patient postoperative positions following rhegmatogenous macula-off retinal detachment surgery.MethodsIn this consecutive clinical study, 26 patients were placed in either the face-up or face-down postoperative position group. Postoperative follow-ups were conducted at 1, 3, and 6 months using type 1 M-CHARTS, best-corrected visual acuity (BCVA), intraocular pressure, and optical coherence tomography imaging to evaluate the functional and anatomical outcomes after surgery.ResultsThe average vision recovery at 6 months was 0.35159 +/- 0.30945 logarithm of the minimum angle of resolution (logMAR) for the face-up group and 0.81521+/- 0.46662 logMAR for the face-down group. At 6 months, the average horizontal type 1 M-CHARTS for the face-up group was 0.1615 +/- 0.1710 and 0.2846 +/- 0.2828 for the face-down group; and the average vertical type 1 M-CHARTS was 0.1615 +/- 0.1557 for the face-up group and 0.2846 +/- 0.1725 for the face-down group.ConclusionThe face-up position demonstrated significant improvement in both metamorphopsia and BCVA, suggesting that slow reattachment of photoreceptors on the retinal pigment epithelium layer can result in better quality of sight recovery.Further studies with larger sample sizes are warranted to confirm these results.The study adhered to the guidelines of the Declaration of Helsinki.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1413-1420"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unrecognized chronic myeloid leukemia manifesting as hemorrhagic complications in proliferative diabetic retinopathy: A case report.","authors":"Shreeya Hinge, Shivraj Tagare, Manavi D Sindal","doi":"10.1177/11206721251334497","DOIUrl":"10.1177/11206721251334497","url":null,"abstract":"<p><p>PurposeTo report a case of proliferative diabetic retinopathy (DR) complicated by concomitant undiagnosed chronic myeloid leukemia (CML).MethodsA known diabetic presented with minimal vitreous hemorrhage in left eye, along with Roth's spots and retinal hemorrhages in both eyes. Fundus fluorescein angiography revealed Proliferative DR with mid peripheral capillary non perfusion and neovascularization. Panretinal photocoagulation was performed, but the patient subsequently developed a vitreous hemorrhage in both eyes, necessitating bilateral vitrectomy. Post operatively both eyes had unexpected massive sub-conjunctival and recurrent vitreous hemorrhage.ResultsRepeat surgery with vitreous lavage and silicon oil injection stabilized the ocular condition. Initial hematological evaluation at baseline had elevated blood sugar levels with normal cell counts. However, six months later, repeat testing revealed leukocytosis, prompting further investigation and a subsequent diagnosis of CML. After treatment for CML silicone oil was removed with a final visual acuity of 20/40 in both eyes.ConclusionThis case reveals the intricate interplay between CML and DR. Subtle ocular findings, including Roth spots, mid-peripheral capillary non-perfusion areas with mid peripheral neovascularization can indicate coexistent CML. Diagnosis of CML may be obscured by normal blood counts, and an interdisciplinary collaboration is required in managing complex cases.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP68-NP72"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uveitis in child treated for acute myeloblastic leukemia: Do not overlook poststreptococcal inflammation.","authors":"Philippe Gardeton, Inés Chabbi, Margaux Camuset, Chloé Couret, Baptiste Le Calvez, Audrey Grain","doi":"10.1177/11206721251334164","DOIUrl":"10.1177/11206721251334164","url":null,"abstract":"<p><p>IntroductionPoststreptococcal uveitis is among the immune complications following strep infections.Case descriptionA patient treated for acute myeloblastic leukemia presented with febrile neutropenia 22 days after consolidation chemotherapy including cytarabine. Diagnosed with <i>Streptococcus mitis</i> bacteremia, she subsequently presented with uveitis in her right eye, linked to the previous infection through positive anti-streptolysin O and negative microbiological test results. Topical treatment resulted in complete recovery.ConclusionThis unprecedented presentation of post-<i>S. mitis</i> uveitis reveals the potential for misdiagnosis of ocular manifestations after cytarabine treatment. Furthermore, neutropenia and profound lymphopenia should not prevent both the ophthalmologist and the hematologist from considering poststreptococcal immune complications.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP58-NP61"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual and refractive outcomes of trocar-assisted intrascleral three-piece intraocular lens fixation.","authors":"Marco Pellegrini, Ginevra Adamo, Michele Nardella, Laura Sarti, Pietro Maria Talli, Francesco Nasini, Marco Mura","doi":"10.1177/11206721241304156","DOIUrl":"10.1177/11206721241304156","url":null,"abstract":"<p><p>PurposeTo report the visual and refractive outcomes of trocar-assisted sutureless intrascleral three-piece intraocular lens (IOL) fixation, and to compare the accuracy of different IOL power formulas in this setting.MethodsTwenty eyes of 20 patients who underwent trocar-assisted sutureless three-piece IOL scleral fixation were included. Two trocar-cannula systems were placed at 3 and 9 o'clock position creating 2.5 mm scleral tunnels. The haptics of a three-piece IOL were grasped with serrated retinal forceps, externalized through the scleral tunnels and fixed by making a flange. Prediction error (PE) was calculated as the actual postoperative spherical equivalent (SE) refraction minus the SE predicted refraction. The predicted SE was calculated using the Barret Universal II, Emmetropia Verifying Optical (EVO), Hoffer Q, Holladay 1, Holladay II, and SRK/T.ResultsAt 6 months after surgery, corrected distance visual acuity improved from 0.66 ± 0.36 to 0.17 ± 0.13 logMAR (<i>p </i>< .001). The lowest median absolute PE was obtained by the Barrett formula (0.73D), followed by the EVO (0.81D), Holladay 1 (0.94D), SRK/T (0.98D), Hoffer Q (1.05D) and Haigis (1.64D) formulas. The highest percentage of eyes within ±1.00 D were obtained with the Barrett (60.0%), and EVO (55.0%) formulas.ConclusionAlthough trocar-assisted intrascleral three-piece IOL fixation yields good visual results, the predictability of refractive outcomes is lower than in standard cataract surgery. All formulas showed a slight tendency towards a hyperopic refractive surprise.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1207-1212"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nepafenac role in macular swelling prevention and in visual outcome after cataract surgery - a systematic review and meta-analysis.","authors":"Malaz Almasri, Amjad Ghareeb, Abdulrahman Ismaiel, Daniel-Corneliu Leucuta, Simona Delia Nicoara","doi":"10.1177/11206721251317652","DOIUrl":"10.1177/11206721251317652","url":null,"abstract":"<p><p>PurposeTo compare Nepafenac effect on foveal thickness (FT), total macular volume (TMV), and BCVA after cataract surgery when added to the common regimen of topical steroids perioperatively.MethodsPubMed, Scopus, EMBASE, the Cochrane Library, and ClinicalTrials.gov were searched systematically on April 28, 2022, for RCTs. Our primary outcome was the change in FT at final follow-up visits. We also considered FT at different follow-up durations, TMV, and visual outcome. We summarized our analyses by calculating the mean differences (MD) with associated 95% confidence intervals (CI) using restricted maximum likelihood in random effects models for continuous outcomes. The individual trials were evaluated for quality utilizing the Cochrane Collaboration's risk of bias assessment tool.ResultsTwenty-four RCTs totaling 4716 eyes were eligible. A significant difference was found between Nepafenac group and control group in the change in FT at final follow-up visit (MD, -11.622; 95% Cl [-17.475, -5.769]), at one week follow-up visit (MD, -6.409; 95% Cl [-13.148, 0.330]), at one month follow-up visit (MD, -9.090; 95% Cl [-13.260, -4.919]), at two months (MD, -5.769; 95% Cl (-22.477, -10.939]), and at three-month follow-up visit (MD, -12.913; 95% Cl [-22.254, -3.572]). However, there was no significant difference between the two groups regarding change in TMV at final follow-up visit. Nevertheless, a significant difference was found between the two groups regarding post-operative BCVA only at three-month follow-up visit.ConclusionTopical Nepafenac in addition to topical steroid is superior to the common regimen of topical steroid alone perioperatively in the prevention of macular swelling.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1421-1431"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brainstem anesthesia after retrobulbar block under brief analgosedation: Evidence for the underlying patho-mechanism.","authors":"M A Thomasius, M Menghini, J Breckwoldt","doi":"10.1177/11206721251333266","DOIUrl":"10.1177/11206721251333266","url":null,"abstract":"<p><p><b>Background:</b> Retrobulbar block is a popular regional anesthetic technique in modern eye surgery due to its excellent anesthetic properties and the provision of globe akinesia. Severe complications including inadvertent subarachnoidal injection, expulsive retrobulbar hemorrhage, and intoxication with local anesthetic, are very rare. However, most reports date back several decades, mechanisms of action are not fully understood, and in recent years the procedure has changed towards facilitating the retrobulbar injection by a brief analgosedation. We therefore describe a case with inadvertent brainstem anesthesia after retrobulbar block concealed behind an analgosedation and provide cCT (cranial computed tomography) images with characteristic pathological findings. <b>Therapy and outcome:</b> A man in his mid-60´s presenting with retinal detachment was scheduled for surgery. After uneventful retrobulbar injection under brief analgosedation, a severe increase of blood pressure and tachycardia occurred while unconsciousness (originally induced by analgosedation) persisted. Hemodynamic alterations were treated with betablockers and antihypertensive agents, and the patient was intubated and mechanically ventilated. The diagnostic workup revealed a dural fissure with intracranial air in the cCT-scan compatible with a perforation of the dura and accidental injection of local anesthetics into the subarachnoidal space. The patient was kept intubated on ICU throughout the respiratory depression and fully recovered without neurological deficits. The vitreoretinal procedure was performed under general anesthesia 36 h after the event. <b>Conclusion:</b> Albeit rare, inadvertent brainstem anesthesia remains a serious adverse event of retrobulbar block. As an important aspect, analgosedation may mask the typical clinical signs making the diagnostic work-up challenging. Furthermore, for the first time we present radiographic imaging findings providing insightful evidence for a possible mechanism of action. Serious complications, such as prolonged hypoxia with potential neurological damage, can successfully prevented by ensuring the presence of a fully equipped and skilled anesthetic team throughout the regional anesthetic procedure.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP62-NP67"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12166138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of smoking on ocular health: A systematic review and meta-meta-analysis.","authors":"Randy Asiamah, Enyonam Ampo, Emmanuel Ekow Ampiah, Mark Ofori Nketia, Samuel Kyei","doi":"10.1177/11206721251334705","DOIUrl":"10.1177/11206721251334705","url":null,"abstract":"<p><p>PurposeTo provide a comprehensive synthesis of the available evidence on the effects of smoking on ocular health.MethodsDatabases (PubMed, SCOPUS, Web of Science) were searched through December 2024 for systematic reviews and meta-analyses on smoking and ocular disease risk. Meta-analysis quality was assessed using the 16-item <i>A MeaSurement Tool to Assess systematic Reviews (AMSTAR) 2</i>.ResultsSixteen studies were included, with 12 qualifying for meta-meta-analysis. Current smokers are 7 to 12 times more likely to develop AMD than non-smokers (Odds Ratio [OR]: 11.93 [95% CI 4.40 to 32.33]; Risk Ratio [RR]: 7.45 [95% CI 4.09 to 13.57]). Past smokers have a seven-fold increased risk (OR: 7.09 [95% CI 4.79 to10.51]). For POAG, current smokers have three times the risk (OR: 3.07 [95% CI 2.07 to 4.54]), and past smokers have three times the risk (OR: 2.64 [95% CI 2.33 to 3.00]). Current smokers are four times more likely to develop cataracts (OR: 4.15 [95% CI 3.35 to 5.15]), while \"ever\" smokers face a six-fold risk (OR: 5.96 [95% CI 3.21 to 11.04]).ConclusionSmoking is a modifiable risk factor for numerous ocular diseases. Public health efforts and clinical guidelines should emphasize smoking cessation to reduce smoking-related ocular disease incidence and promote ocular health.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1506-1518"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of submacular hemorrhage with bacillary layer detachment and intrabacillary hemorrhage.","authors":"Ayushi Choudhary, Saloni Kapoor, Gaurang Sehgal, Priyanka Gandhi, Rupal Kathare, Vishma Prabhu, Prathiba Hande, Naresh Kumar Yadav, Jay Chhablani, Ramesh Venkatesh","doi":"10.1177/11206721241300204","DOIUrl":"10.1177/11206721241300204","url":null,"abstract":"<p><p>PurposeTo study the outcomes of patients presenting with submacular hemorrhage (SMH) and bacillary layer detachment (BALAD) following intervention.MethodsThis retrospective study examined fundus photographs and optical coherence tomography (OCT) scans to identify treatment-naive SMH and BALAD cases. Two groups were formed: SMH cases with and without BALAD. The treatment outcomes of these cases were assessed.ResultsThirteen (65%) of the 20 eyes with SMH had BALAD. Blunt trauma was the most common cause of SMH (n = 10, 50%). Median age was 46 years (IQR range: 28-70). Demographic, clinical, or OCT imaging findings between the groups (<i>p</i> > 0.05) were comparable. Nine (45%) patients each underwent intravitreal gas injection alone or along with PPV and TpA injection. At 1-month post-treatment, VA improved (logMAR VA - 0.89; <i>p</i> = 0.017). BALADs and intrabacillary hemorrhage had resolved in eight (61%) cases. Intraretinal, subretinal, and sub-RPE fluids resolved in 100%, 70%, and 43% of cases, respectively. Eyes with resolved BALAD showed greater improvement in VA (logMAR VA - 0.98) than eyes with persisting BALAD (logMAR VA - 1.1) and resulted in significant decrease in central macular (<i>p</i> = 0.016) and retinal thicknesses (<i>p</i> = 0.031). SMH eyes without pre-treatment BALAD also observed statistically significant improvement in visual acuity following intervention (<i>p</i> = 0.031).ConclusionBALAD and intrabacillary hemorrhage in SMH are relatively common. A significant proportion of cases had their BALAD and intrabacillary haemorrhage resolved following treatment. Persistence of BALAD had no effect on VA.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1349-1357"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental burden of ocular surface discomfort.","authors":"Antonio Di Zazzo, Chiara De Gregorio, Sara Spelta, Senol Demircan","doi":"10.1177/11206721241305661","DOIUrl":"10.1177/11206721241305661","url":null,"abstract":"<p><p>ObjectiveThis research investigates the associations between Dry Eye Disease (DED), pain perception, and mental health, focusing on how neuropathic pain influences treatment efficacy and patients' quality of life.Methods and ResultsThe study delves into the complexity of DED by assessing the correlation between ocular pain, depression, PTSD, and systemic pain conditions. It highlights the role of chronic neuropathic pain in DED and the nociceptive hypothesis, which suggests that psychological stress can exacerbate DED symptoms. Additionally, it explores diagnostic and management strategies for DED, emphasizing the importance of considering psychological aspects to improve patient care.ConclusionsThe intricate nature of DED, closely linked to mental health issues, requires a comprehensive diagnostic and therapeutic approach. Addressing neuropathic pain and psychological factors is crucial for effective DED management. Future efforts should focus on developing specific interventions targeting DED's physical and emotional impacts to enhance overall patient well-being.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1445-1455"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}