European Journal of Ophthalmology最新文献_第4页

Three-years follow-up of combined phacoemulsification, iStent and endocyclophotocoagulation. 超声乳化术、体外吸入术及内环光凝术联合随访3年。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-02 DOI: 10.1177/11206721251338996

Celia Fernandez-Alcalde, Lee Jones, Anca Delia Pantalon, Gokulan Ratnarajan

{"title":"Three-years follow-up of combined phacoemulsification, iStent and endocyclophotocoagulation.","authors":"Celia Fernandez-Alcalde, Lee Jones, Anca Delia Pantalon, Gokulan Ratnarajan","doi":"10.1177/11206721251338996","DOIUrl":"https://doi.org/10.1177/11206721251338996","url":null,"abstract":"ObjectivesTo assess the efficacy and safety of phacoemulsification combined with endocyclophotocoagulation (ECP) and iStent implantation in surgically naïve patients.MethodsRetrospective observational cross-sectional series of 82 surgically naïve eyes treated with combined phacoemulsification, ECP and iStent between January 2018 and July 2019 at a single centre facility.ResultsA total of 82 eyes underwent the procedure. Average age was 80.9 (±6.4) years and 61% were female. Fifteen (18.29%) eyes had preperimetric glaucoma, the remaining were primary open angle glaucoma as follows: mild 32.92% (N = 27), moderate 35.37% (N = 29) and advanced 13.41% (N = 11). Baseline mean IOP was 19.5 (±4.5) mmHg, falling to 14.4 (±3.2) mmHg at 36-months (p ≤ 0.001). 82% of eyes were a qualified success at 3-year post-op with IOP ≤ 18 mmHg. 26% of eyes were a complete success at 3-years with IOP ≤ 18 mmHg and no medications. At baseline, mean number of medications was 2 reducing to 1.3 ± 1.1 at 3-years; Nineteen (23.2%) were patients medication-free. Best corrected visual acuity improved, increasing from 0.28 ± 0.2 LogMAR preoperatively to 0.10 ± 0.1 LogMAR at 36-months follow-up (p ≤ 0.001). Two patients developed cystoid macular oedema that resolved with topical treatment. Average MD remained stable over 3-years (p = 0.94). Due to suboptimal IOP, 3 patients underwent selective laser trabeculoplasty (SLT). No patients required further glaucoma surgical intervention.ConclusionsCombination of cataract surgery with iStent and ECP is a safe and effective procedure to lower IOP and medication burden. The procedure halted glaucoma progression and prevented further surgery over a 3-years follow up.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251338996"},"PeriodicalIF":1.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nontargeted metabolomics analysis in allergic conjunctivitis. 过敏性结膜炎的非靶向代谢组学分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-02 DOI: 10.1177/11206721251338495

Nagihan Demirtas, Onur Senol, Emine Cinici, Büşra Sahin Mazlumoglu, Mehmet Atakay, Bekir Salih, Saziye Sezin Palabiyik-Yucelik

{"title":"Nontargeted metabolomics analysis in allergic conjunctivitis.","authors":"Nagihan Demirtas, Onur Senol, Emine Cinici, Büşra Sahin Mazlumoglu, Mehmet Atakay, Bekir Salih, Saziye Sezin Palabiyik-Yucelik","doi":"10.1177/11206721251338495","DOIUrl":"https://doi.org/10.1177/11206721251338495","url":null,"abstract":"PurposeAllergic conjunctivitis is a disease with a high prevalence in the world. In this study, untargeted metabolomics analyzes were performed to investigate the metabolic profile of the disease in serum samples of allergic conjunctivitis patients.MethodsSerum samples were obtained from 20 allergic conjunctivitis patients and 20 healthy subjects. Untargeted metabolomics analyzes were performed by LC/Q-TOF/MS (liquid chromatography quadrupole time-of-flight mass spectrometry) method. Data collection, classification and identification were performed with the METLIN database and XCMS.ResultsA total of 152 different metabolites were identified and labeled. All annotated metabolites exhibited a 1.5-fold change (increase or decrease) and had a p-value of less than or equal to 0.05 when comparing groups. All statistical data indicated that the model was statistically significant and the p-value is less than or equal to 0.05. All annotated metabolites were evaluated and pathway analysis were performed with significantly altered metabolites.ConclusionIn this study, significant differences in histamine, fatty acid, sphingolipid, purine, vitamin and melatonin metabolism were observed in allergic conjunctivitis patients. It has been determined that disruption of the cell barrier due to changes in fat metabolism, activation of inflammation pathways and irregularity in sphingolipid metabolism play an important role in the underlying mechanisms of allergic conjunctivitis.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251338495"},"PeriodicalIF":1.4,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of Fovea Plana in patients with rhegmatogenous retinal detachment. 流变性视网膜脱落患者的眼窝普拉纳患病率。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-09-23 DOI: 10.1177/11206721241286125

Vasileia Chatzistergiou, Raphaël Lejoyeux, Sophie Bonnin, Ramin Tadayoni

{"title":"Prevalence of Fovea Plana in patients with rhegmatogenous retinal detachment.","authors":"Vasileia Chatzistergiou, Raphaël Lejoyeux, Sophie Bonnin, Ramin Tadayoni","doi":"10.1177/11206721241286125","DOIUrl":"10.1177/11206721241286125","url":null,"abstract":"PurposeTo assess the prevalence of fovea plana in patients with rhegmatogenous retinal detachment and compare characteristics of the detachment between patients with and without fovea plana.MethodsThis retrospective, cross-sectional, case-control study included individuals with rhegmatogenous retinal detachment. We collected demographics and data on the operated eye, spherical equivalent, best-corrected visual acuity, lens status, macula status, number of retinal holes or tears, and presence of intravitreal hemorrhage, macular hole, epiretinal membrane, posterior vitreous detachment and proliferative vitreoretinopathy. The type of surgery, the tamponade, and cataract surgery following retinal surgery were also recorded. Spectral-domain optical coherence tomography macular cubes were used to evaluate the fovea by using the Spectralis HRA-OCT device (Heidelberg Engineering, Germany). Images were graded by two different investigators and a third investigator in case of disagreement.ResultsWe included 204 individuals; 35 (17.2%) had fovea plana, a proportion significantly higher than in the general population (p = 0.041). Individuals with and without fovea plana did not differ in any of the characteristics mentioned above apart from posterior vitreous detachment, which was more frequent in those with than without fovea plana (p = 0.038).ConclusionThe prevalence of fovea plana is higher in patients with rhegmatogenous retinal detachment, which suggests an association between fovea plana and potential vitreoretinal interface changes.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1098-1102"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Late corneal guttae recurrence in bilateral penetrating keratoplasty grafts. 双侧穿透性角膜移植术后角膜瘘管晚期复发。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-01-10 DOI: 10.1177/11206721241313000

Andrea C Santiago-Leon, Charissa H Tan, Sander R Dubovy, Ellen H Koo

{"title":"Late corneal guttae recurrence in bilateral penetrating keratoplasty grafts.","authors":"Andrea C Santiago-Leon, Charissa H Tan, Sander R Dubovy, Ellen H Koo","doi":"10.1177/11206721241313000","DOIUrl":"10.1177/11206721241313000","url":null,"abstract":"BackgroundTo describe a case of guttae recurrence in bilateral corneal grafts in a patient with a known diagnosis of Fuchs endothelial dystrophy, more than three decades following penetrating keratoplasty.MethodsCase Report.ResultsA 79-year-old White woman presented with declining vision, right eye worse than the left. She had previously undergone bilateral penetrating keratoplasty (P.K.) for Fuchs Endothelial Keratoplasty 35- and 34- years ago, of the right and left eye respectively. The slit-lamp biomicroscopy exam revealed corneal edema as well as presence of guttae affecting bilateral grafts. She underwent PK of the right eye. Histopathological analysis of the removed PK graft showed posterior nodular excrescences consistent with guttae.ConclusionGuttae development in corneal grafts is relatively uncommon and the mechanism of this entity remains unclear. The observation of guttae development in transplanted grafts has raised questions surrounding donor cornea screening and evaluation by eye banks, as well as those relating to recipients' genetics and intrinsic factors that lead to guttae recurrence in the transplanted grafts. We herein describe the case of guttae recurrence in bilateral corneal grafts in a patient with a known diagnosis of Fuchs endothelial dystrophy, more than 34 years following penetrating keratoplasty.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP14-NP17"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DMEK Surgical Strategy in Aphakic and Vitrectomized Eyes. 无晶状体和玻璃体切除眼的DMEK手术策略。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-01-03 DOI: 10.1177/11206721241310623

José Luis Güell, Martina Aguilera Zúñiga, Hugo Alonso-Reyes, Nuno Moura-Coelho, Eloyna Lindez-Pérez

引用次数: 0

Myoring implantation with and without cross-linking: Comparative study of pre and postoperative visual outcomes and pentacam indices. 有交联和无交联的 Myoring 植入术：术前和术后视觉效果与 pentacam 指数的比较研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-11 DOI: 10.1177/11206721241298032

Fathy Fawzy Morkos, Nader Fathy Fawzy, Mohamed El Bahrawy, Omnia Talaat, Rania Serag Elkitkat

{"title":"Myoring implantation with and without cross-linking: Comparative study of pre and postoperative visual outcomes and pentacam indices.","authors":"Fathy Fawzy Morkos, Nader Fathy Fawzy, Mohamed El Bahrawy, Omnia Talaat, Rania Serag Elkitkat","doi":"10.1177/11206721241298032","DOIUrl":"10.1177/11206721241298032","url":null,"abstract":"ObjectivesComparing the visual, topographic, and aberrometric changes following Myoring implantation alone or combined with corneal cross-linking (CXL).MethodsThis retrospective, comparative study was conducted on keratoconus (KC) patients with moderate, central KC who sought medical advice at Watany Eye Hospital, Cairo, Egypt. Group 1 patients performed femtolaser-assisted Myoring implantation, while group 2 patients performed Myoring implantation with CXL.ResultsGroup 1 included 44 eyes, and group 2 comprised 40 eyes. The mean follow-up interval was 2.34 years ± 2.25. There was a significant postoperative improvement in subjective refraction for both groups. Patients of group 1 showed statistically significant reductions in postoperative topographic astigmatism, K readings, Index of Surface Variance, horizontal coma, and spherical aberrations. In contrast, patients of group 2 only showed statistically significant improvements in K readings and horizontal coma. Patients of group 1 developed higher improvements in topographic astigmatism and K max compared to group 2.ConclusionAlthough the combined technique was non-inferior to implanting the Myoring alone regarding visual, refractive, and keratometric improvements, Myoring implantation alone showed better results, mainly in topographic astigmatism. Hence, our study leans in favor of Myoring implantation without the need for additional CXL.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"910-916"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proliferative retinopathy in a patient with mutation in the CLCN2 gene. CLCN2基因突变患者的增殖性视网膜病变。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2025-02-21 DOI: 10.1177/11206721251316612

Waseem Nasser, Hadas Pizem, Yonatan Butbul Aviel, Tova Hershkovitz, Galit Tal, Shiri Zayit-Soudry, Efrat Naaman

{"title":"Proliferative retinopathy in a patient with mutation in the CLCN2 gene.","authors":"Waseem Nasser, Hadas Pizem, Yonatan Butbul Aviel, Tova Hershkovitz, Galit Tal, Shiri Zayit-Soudry, Efrat Naaman","doi":"10.1177/11206721251316612","DOIUrl":"10.1177/11206721251316612","url":null,"abstract":"PurposeCLCN2 is a gene that encodes the voltage-gated chloride channel protein 2 in the human brain and eyes. While mutations in this gene have been associated with leukoencephalopathy as well as ocular manifestations including optic neuropathy and choroidopathy, here we report for the first time a case of severe proliferative retinopathy in a patient with CLCN2 mutation.ObservationsA 12-year-old girl with Familial Mediterranean Fever (FMF) was referred due to blurred vision in both eyes. Ophthalmoscopic examination revealed mild vitreous hemorrhage, large neovascularization at the disc (NVD), extensive neovascularization along the arcades (i.e., NVE; neovascularization elsewhere), retinal arteriolar narrowing, silver sheathing of the veins and preretinal hemorrhages. Fluorescein angiography (FA) demonstrated prominent leakage from multiple large NVEs. A thorough and multidisciplinary evaluation ruled out metabolic, thrombotic, infectious, inflammatory, or autoimmune etiologies. Notably, however, brain magnetic resonance imaging (MRI) revealed leukodystrophy yet poorly correlated with her clinical manifestation. Strikingly, whole exome sequencing uncovered a homozygous mutation in the CLCN2 gene. She was treated with intravitreal injections of the anti-vascular endothelial growth factor (VEGF) antibody Bevacizumab and laser pan-retinal photocoagulation (PRP) with partial response.ConclusionsThis case suggests that CLCN2 mutation may possess a key role in an aggressive form of proliferative retinopathy with partial response to anti-VEGF therapy. We hypothesize that the potential underlying mechanism involves astrocyte dysfunction and retinal blood barrier disruption. Noteworthy, a comprehensive approach is unequivocally significant in evaluating such cases of proliferative retinopathy with unclear etiology to establish a diagnosis and management strategy.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP46-NP52"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review: Clinical findings and genetic characterization of children affected with X-linked retinoschisis in the Spanish population. 回顾：西班牙人群中x连锁视网膜裂儿童的临床表现和遗传特征。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-12-08 DOI: 10.1177/11206721241305244

Oriana D'Anna Mardero, Natalia Arruti Vázquez, Javier Francisco Coca Robinot, Jesús Peralta Calvo, Victoria Ef Montaño, Elena Vallespín, Susana Noval Martín

{"title":"Review: Clinical findings and genetic characterization of children affected with X-linked retinoschisis in the Spanish population.","authors":"Oriana D'Anna Mardero, Natalia Arruti Vázquez, Javier Francisco Coca Robinot, Jesús Peralta Calvo, Victoria Ef Montaño, Elena Vallespín, Susana Noval Martín","doi":"10.1177/11206721241305244","DOIUrl":"10.1177/11206721241305244","url":null,"abstract":"X-linked retinoschisis (XLRS) is an inherited retinal disorder due to mutations in retinoschisin 1, characterized by impaired central vision secondary to parafoveal cystic cavities and visual field loss by splitting through the retinal nerve fibre layer in the peripheral retina. It is the leading cause of juvenile macular degeneration in males, and currently there is no approved treatment but carbonic anhydrase inhibitors can be used. A retrospective review of the medical records of 17 children with confirmed XLRS seen in the Paediatric Ophthalmology Department of La Paz University Hospital from the 1st of January 2009 to the 1st of June of 2023 was conducted. Complete ophthalmological studies, genetic testing and full-field electroretinogram were performed. Topical brinzolamide was given to patients with foveoschisis, adding oral acetazolamide in those who did not improve with topical treatment alone or with very extensive foveoschisis at diagnosis. Surgical treatment was performed in retinal detahment (RD) or in no clearing hemovitreous cases. Mean age at diagnosis was 5,86 years and the most common reason for consultation was strabismus, followed by RD. The most frequently affected retinal later on Optic coherence tomography was the inner nuclear layer and throughout the follow-up we observed a decrease in central macular thickness. We found some genotype-phenotype correlation in our series and more severe phenotypes if the first amino acid of the protein is affected or in frameshift mutations. We found that medical treatment (topical and oral) improves foveoschisis, and that surgery shows poor outcomes, especially in younger patients.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"809-820"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of different forms of exercise on intraocular pressure, blood flow, and the risk for primary open angle glaucoma. 不同形式的运动对眼压、血流量和原发性开角型青光眼风险的影响。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-08 DOI: 10.1177/11206721241296027

Michael Sidoti, Alon Harris, Janet Coleman-Belin, Alice Verticchio Vercellin, Gal Antman, Francesco Oddone, Carmela Carnevale, Isaac Tessone, Brent Siesky

{"title":"The impact of different forms of exercise on intraocular pressure, blood flow, and the risk for primary open angle glaucoma.","authors":"Michael Sidoti, Alon Harris, Janet Coleman-Belin, Alice Verticchio Vercellin, Gal Antman, Francesco Oddone, Carmela Carnevale, Isaac Tessone, Brent Siesky","doi":"10.1177/11206721241296027","DOIUrl":"10.1177/11206721241296027","url":null,"abstract":"Primary open angle glaucoma (POAG) is a chronic disease characterized by progressive optic nerve damage and irreversible loss of vision, often diagnosed at late stages. Elevated intraocular pressure (IOP) is the major risk factor for its onset and progression while older age, myopia, genetic factors, blood pressure (BP), and reduced ocular blood flow (OBF) have also been linked to the disease. Different forms of exercise are known to have significant, but variable, effects on IOP, BP, ocular perfusion pressure (OPP), OBF and oxygen metabolism, and ultimately the risk for development and progression of POAG. While population-based studies lack agreement regarding the relationship between exercise and POAG status, data suggests that resistance training causes a short-term increase in IOP, BP, and OPP. Conversely, aerobic exercise has been shown to cause a short-term decrease in IOP and increase in BP and OPP. Research also suggests that following an exercise program over an extended period may lead to a long-term decrease in IOP, however its cessation results in a prompt return to baseline levels. Data suggests normal vascular autoregulation ensures minimal change in OBF following extended exercise unless OPP rises ∼70% above baseline. Although exercise may alter IOP, BP, and OBF, both acutely and chronically, it is currently uncertain if physical activity significantly alters risk for the onset and progression of POAG.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"834-843"},"PeriodicalIF":1.4,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epiretinal large disc of lyophilized amniotic membrane without retinotomy or PFCL for highly myopic macular hole retinal detachment. 不进行视网膜切开术或 PFCL 治疗高度近视黄斑孔视网膜脱离的冻干羊膜视网膜外大圆盘。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-05-01 Epub Date: 2024-11-25 DOI: 10.1177/11206721241297027

Thibaud Garcin

引用次数: 0