European Journal of Ophthalmology最新文献

{"title":"Medical and surgical treatment management in open angle glaucoma patients of Asian descent: A narrative review.","authors":"Aditya V Belamkar, Alon Harris, Barbara Wirotsko, Lucas Rowe, Francesco Oddone, Carmela Carnevale, Alice Verticchio Vercellin, Kunal Kanwar, Keren Wood, Anna Fabczak-Kubicka, Brent Siesky","doi":"10.1177/11206721251340435","DOIUrl":"10.1177/11206721251340435","url":null,"abstract":"<p><p>Glaucoma represents a progressive optic neuropathy characterized by optic nerve head damage, retinal nerve fiber layer thinning and visual field loss. There are significant disparities in the diagnosis, disease progression and treatment outcomes of glaucoma patients. Primary open angle glaucoma (OAG) patients of African descent have been found to have earlier and more severe disease than those of European descent. In 2020, half of the worldwide glaucoma patient population resided in Asia, where normal-tension and angle-closure glaucoma are more prevalent. The significant prevalence and diversity of OAG in Asia necessitates a better understanding of medical, laser, and surgical management in this growing population. PubMed and Embase database searches were conducted for all pertinent articles and abstracts published between January 1990 through January 2024 and review of the literature yielded 1,237 potential articles, from which 104 met the inclusion/exclusion criteria. The current literature suggests that prostaglandin analogues are efficacious and safe in OAG Asian patients, however little is known on other classes of hypotensive drugs. Published data on the laser and surgical management of glaucoma in Asian populations describe differences in outcomes between Asian and Caucasian populations including from minimally invasive glaucoma surgery. Longitudinal studies specifically designed to investigate treatment impact while accounting for access to care in the increasing global aging Asian population are warranted.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1883-1895"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12352580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitreous level of tumor necrosis factor alpha in patients with macular edema secondary to retinal vein occlusion.","authors":"Mohamed Attya, Amira Taha, Sherif Ali Gamal Eldin, Riham Assem Elessawy, Ahmed Abdallah Mohalhal","doi":"10.1177/11206721251332791","DOIUrl":"10.1177/11206721251332791","url":null,"abstract":"<p><p>PurposeRetinal vein occlusion (RVO) induces ischemia that triggers the release of inflammatory cytokines, including tumor necrosis factor alpha (TNF- α). We aimed at measuring TNF- α level in vitreous samples of treatment naïve RVO patients.Material and Methodsthis is a case control study. The study was conducted on 45 eyes (20 eyes with treatment naïve RVO associated with macular edema & 25 eyes of patients undergoing cataract surgery as control). Vitreous samples were collected using 25 gauge needle connected to 1 milliliters (ml) syringe and the level of TNF- α was assessed using Enzyme-linked Immunosorbent Assay (ELISA) Kits<b>.</b>ResultsThe mean age of RVO cases was 51.50 ± 12.86 years while controls was 55.76 ± 6.88 years (P value =0.192). Vitreous level of TNF-α was statistically significant higher in RVO patients [4.92 ± 0.74 picograms (pg)/ ml] than control [3.54 ± 0.60 pg/ml]; p value < 0.001. Vitreous TNF-α level in ischemic and non-ischemic RVO subgroups was 4.94 ± 0.69 pg/ml and 4.89 ± 0.89 pg/ml respectively that wasn't statistically significant (p value = 0.885) and its level in branch and central RVO subgroups was 5.02 ± 0.79 pg/ml and 4.84 ± 0.73pg/ml respectively not statistically significant (p value = 0.592).ConclusionsTNF-α level is increased in vitreous of RVO associated macular edema patients, thus, it may be involved in its pathogenesis and Anti-TNF-α might be used as treatment targets in the future.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1710-1716"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Intravitreal injection pain reduction using topical NSAIDS: A comparative study.","authors":"Chen Shtayer, A Lily Okrent Smolar, Mohamad Elmalak, Lena Abayev, Andrzej Grzybowski, Elad Moisseiev","doi":"10.1177/11206721231201176","DOIUrl":"10.1177/11206721231201176","url":null,"abstract":"<p><p>PurposeTo compare the efficacy of two different topical non-steroidal anti-inflammatory drugs (NSAIDs) drops with versus without conservatives after intravitreal injections (IVIs).DesignProspective, randomized, placebo-controlled, single-blinded comparative study.Participants and methodA total of 308 eyes of 252 patients receiving an IVI of anti-vascular endothelial growth factor (anti-VEGF) were randomly assigned to receive either a single drop of nepafenac 0.1%, preservative-free diclofenac 0.1%, or artificial tears (control group) immediately after IVI. Primary outcome measure was pain scores immediately, six hours and twenty-four hours post- injection.Results166 patients received one topical drop of NSAIDS, of which 90 in the diclofenac group and 76 in the nepafenac group. Additional 86 patients were included in the control group. Mean reported pain score was significantly lower at six hours after IVI in the preservative-free diclofenac group (17.1 ± 23.0) than in the nepafenac group (26.2 ± 31.9) and the control group (27.5 ± 29.2) (p = 0.03). At twenty-four hours post-injection there was no statistically significant difference between the groups. Patients reported less pain compared to previous IVIs and none referred to urgent health care, but these findings were not statistically significant.ConclusionsThe use of topical preservative-free NSAIDs may be superior to preservative- containing NSAIDs in pain relief after IVIs and may be considered as part of the treatment protocol of this population.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1703-1709"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10257120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IOP changes and correlation with alterations in corneal biomechanics and time of useful consciousness following controlled hypobaric hypoxic exposure.","authors":"Efthymios Karmiris, Styliani Totou, Anastasia Tsiogka, Evangelia Chalkiadaki, Konstantinos Tsiripidis, Vassilios Kozobolis, Panagiotis Stavrakas","doi":"10.1177/11206721251332756","DOIUrl":"10.1177/11206721251332756","url":null,"abstract":"<p><p>PurposeTo evaluate changes in intraocular pressure (IOP), central corneal thickness (CCT) and corneal biomechanics before and after exposure to hypobaric hypoxia, accounting also for Time of Useful Consciousness (TUC) as a parameter of short time exposure to systemic hypoxia.MethodsThis prospective, observational study recruited 45 healthy individuals training in Hypobaric Chamber. IOP, CCT and corneal biomechanics were evaluated before and immediately after the end using the Corvis ST. Comparisons of score values before and after hypoxia were performed with paired t-test for normally distributed differences. Difference between the IOP measurements was correlated with differences in CCT, corneal biomechanics and TUC with multivariate mixed effect linear regression models.ResultsBiomechanically corrected IOP (bIOP-Corvis) and pneumotonometry IOP as produced by Corvis ST (NCT) showed statistically significant higher values before hypoxia (<i>p</i> = 0.048 and <i>p</i> = 0.047 respectively). We observed a strong negative correlation of the difference between bIOP-Corvis before and after hypoxia with the difference in Deformation amplitude ratio (DARatio) (<i>p</i> < 0.001) and a significant positive correlation with the difference in Integrated Inverse Radius(IntegrRadius) (<i>p</i> = 0.01), Stiffness parameter at the first applanation (SPA1) (<i>p</i> < 0.001) and TUC (<i>p</i> = 0.023). We observed a strong negative correlation of the difference between NCT before and after hypoxia with the difference in DARatio (<i>p</i> < 0.001) and a significant positive correlation with the difference in IntegrRadius (<i>p</i> = 0.023), SPA1 (<i>p</i> < 0.001) and TUC (<i>p</i> = 0.025). <b>The R-squared values of the regression models were 0.6420 and 0.6626 for the bIOP and NCT respectively.</b>ConclusionWe demonstrated reduction in IOP after hypoxia exposure. A combination of alterations in corneal biomechanics explain a degree of this IOP reduction, whereas CCT did not have a significant role in IOP changes.TUC was found to significantly <b>correlate with</b> IOP changes.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1604-1613"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical evaluation of a new sinusoidal-patterned trifocal intraocular lens: 6-month outcomes.","authors":"Serkan Kılınç, Erdem Ergen, David P Piñero","doi":"10.1177/11206721251338516","DOIUrl":"10.1177/11206721251338516","url":null,"abstract":"<p><p>PurposeTo analyze the 6-month clinical outcomes of cataract surgery with implantation of a new trifocal intraocular lens (IOL).MethodsProspective multicenter study enrolling a total of 202 eyes of 101 patients that underwent uncomplicated phacoemulsification cataract surgery with bilateral implantation of the Trinova Pro C IOL (VSY Biotechnology GmbH, Leinfelden-Echterdingen, Germany). Changes in refraction, uncorrected (UDVA) and corrected distance (CDVA), uncorrected (UIVA) and distance-corrected intermediate (DCIVA) and uncorrected (UNVA) and distance-corrected near visual acuity (DCNVA) during a 6-month follow-up were evaluated. The binocular defocus curve was measured at 6 months postoperatively and photopic and mesopic contrast sensitivity (CS) with and without glare.ResultsPostoperative spherical equivalent was within ±1.00 D in 91% of eyes, respectively. Significant improvements were found in all visual acuities at 1 month postoperatively (p < 0.001). Mean 6-month postoperative monocular logMAR UDVA, UIVA and UNVA were 0.02 ± 0.06, 0.15 ± 0.14, and 0.14 ± 0.12, respectively. Mean 6-month postoperative monocular logMAR CDVA, DCIVA, and DCNVA were 0.01 ± 0.03, 0.14 ± 0.14, and 0.14 ± 0.12, respectively. Mean visual acuities values of 0.10 logMAR or better were found for defocus levels between +0.50 and -2.50 D. Minimal changes were observed in CS in both photopic and mesopic conditions when using the glare source (p > 0.05).ConclusionsThe trifocal IOL evaluated provides an efficient distance, intermediate and near visual function in subjects undergoing uneventful cataract surgery, with stable results during a 6-month follow-up and good levels of visual quality.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1554-1561"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of a cross-platform digital visual acuity measurement system.","authors":"Juan C Costa, Daniel M Amorim, Paulo R Lins","doi":"10.1177/11206721251336001","DOIUrl":"10.1177/11206721251336001","url":null,"abstract":"<p><p>PurposeThis study aimed to validate visual acuity measurements using a cross-platform system in an ophthalmological setting.MethodsVisual acuity was assessed at a distance of 5 m using two different modalities: printed and digital optotypes. The devices included Android, LG WebOS and Samsung Tizen smart TVs. Optotypes were presented in the logMAR scale. Two modalities, a single row and a block of symbols, presented SLOAN letters and Tumbling-E symbols.ResultsVisual acuity measurements of 190 participants aged 12 to 60 years demonstrated good-to-strong test-retest correlation (ICC > 0.75) and minimal bias (-0.03 to 0.02 logMAR). Limits of agreement were comparable to other studies (0.13-0.26 logMAR), with the smallest values for Tumbling-E row presentation in all devices and the highest value for Sloan chart in LG device. ANOVA revealed no statistical differences in visual acuity across devices. Sloan letters showed superior visual acuity compared to Tumbling-E (<i>p</i> < 0.001), however, this difference corresponded to only 2 letters of visual acuity.ConclusionThe digital cross-platform evaluated serves as a versatile substitute for traditional visual acuity assessments in individuals aged 12 years and older. Further research is necessary for patients with visual acuity worse than 0.5 logMAR and for conducting vision screenings in young children.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1824-1832"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in the global disease burden of age-related macular degeneration from 1990 to 2021.","authors":"Zongyi Zhan, Zijing Li","doi":"10.1177/11206721251339231","DOIUrl":"10.1177/11206721251339231","url":null,"abstract":"<p><p>AimTo investigate the global disease burden of age-related macular degeneration (AMD) from 1990 to 2021 using data from the Global Burden of Diseases 2021 database.MethodsWe recorded disability-adjusted life years (DALYs) and rates and estimated annual percentage changes (EAPCs) in AMD stratified by sex, age, sociodemographic index (SDI), geographic region, country, and risk factor.ResultsGlobally, the number of AMD-associated DALYs increased from 302,902 in 1990 to 578,020 in 2021, while the age-standardized rate (ASR) of DALYs decreased by 19.089% from 1990 to 2021, with an EAPC of -0.942 (95% CI, -1.010-0.873). During this period, males had fewer DALYs and lower ASRs than did females, and the ASR decreased with decreasing age. In 2021, the low-SDI region had the highest ASR (10.082 per 100,000 individuals) and the slowest ASR decrease (EAPC: -0.652, 95% CI, -0.708--0.595). East Asia had the most DALYs (154,300.168), and Western Sub-Saharan Africa had the highest ASR (14.735 per 100,000 individuals). From 1990 to 2021, all 21 regions experienced increased DALYs, while most regions, except for Central Sub-Saharan Africa and Southern Sub-Saharan Africa, experienced decreases in the ASR. China had the most DALYs (153,219.726) in 2021. The proportion of DALYs attributable to smoking in patients with AMD decreased globally and across all SDI regions from 1990 to 2021.ConclusionOver the past 32 years, AMD has remained a significant health concern, particularly affecting females, older individuals, and individuals living in lower-SDI regions, with a global decline in smoking-related AMD DALYs.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1627-1636"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of complications in enucleated patients with porous polyethylene implants for uveal melanoma.","authors":"Ignacio López Miñarro, Ciro García Álvarez, María Fe Muñoz Moreno, Laura Prieto Domínguez, María Antonia Saornil Álvarez","doi":"10.1177/11206721251334701","DOIUrl":"10.1177/11206721251334701","url":null,"abstract":"<p><p>PurposeThis study aimed to assess the complication rate of porous polyethylene (PP) implants in patients who underwent enucleation for uveal melanoma and to explore the link between complications and surgical factors.MethodsA retrospective cohort study was conducted on consecutive cases treated at the Ocular Oncology Unit, University Clinical Hospital of Valladolid, from 1995 to 2023. Complications were classified as mild (managed conservatively) or severe (requiring implant removal or replacement). Kaplan-Meier curves analyzed complication timing.ResultsThe study included 193 patients, with an average age of 63.6 years and a mean follow-up of 65.9 months. Results showed that 54 complications (28%) were recorded, with 13 (6.7%) classified as severe, and 55.6% of complications occurred within the first three years. Implant wrapping varied: 50.3% with sclera, 11.9% with bovine pericardium, and 33.2% not wrapped. The study found no significant difference in implant survival between wrapped and unwrapped implants or between different sizes (<i>p</i> > .05).ConclusionThe findings suggest that PP implants have a low rate of severe complications in uveal melanoma patients and that complication risk is not significantly impacted by wrapping or implant size.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1786-1794"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optogenetic therapy for retinal degenerative diseases: A review.","authors":"Ehab Kasem, Masa Watfa, Ali Afif, Raghad Hasan, Majd Mansour, Haya Almhmoud, Basem Zaino","doi":"10.1177/11206721251335560","DOIUrl":"10.1177/11206721251335560","url":null,"abstract":"<p><p>Optogenetics, a cutting-edge tool in novel gene manipulation and drug discovery, holds significant therapeutic potential for a variety of neurological disorders, including retinal diseases. Retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP), significantly impair quality of life and cause severe visual impairment due to limited treatment options and a general lack of awareness. The increasing incidence of these degenerative conditions underscores the need for innovative solutions, such as optogenetics. Optogenetic therapy introduces genes coding for light-sensitive proteins, which are controlled by light signals to make neurons photosensitive. This precise targeting approach does not require specific gene intervention and can bypass dysfunctional photoreceptors, offering a treatment option for various degenerative and dystrophic eye diseases. Successful outcomes in patients with late-stage genetic retinal diseases and numerous clinical trials suggest that optogenetics could be an effective treatment for humans. This review provides an overview of the current landscape of optogenetic therapy, discusses its challenges, and summarizes the findings of ongoing clinical trials for neural and visual restoration.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1901-1920"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical outcomes and vault between two types of posterior phakic intraocular lenses in correction of myopia and myopic astigmatism.","authors":"Alexandre Chingan, Adil El Maftouhi, M Gobeaut, Pauline El Kaim, Christophe Baudouin, Liem Trinh","doi":"10.1177/11206721251323642","DOIUrl":"10.1177/11206721251323642","url":null,"abstract":"<p><p>PurposeTo compare refractive and clinical outcomes of two posterior chamber phakic intraocular lenses (pIOLs) for correction of myopia and myopic astigmatism. To evaluate the vault and its variance for the phakic lenses by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM).SettingQuinze-Vingts National Ophthalmology Hospital, Paris, France.Designretrospective case seriesMethodsPatients received an Implantable Collamer Lens (V5 EVO + ICL, Staar surgical AG, Switzerland) or Intraocular Phakic Contact Lens (V2.0 IPCL Caregroup Sight Solution, India). AS-OCT, optical biometry and corneal topography were performed to measure biometric parameters and evaluate post-operative vault.Results12 eyes received an ICL and 14 eyes an IPCL. At 12 months postoperatively, the mean UDVAs were 0.06 ± 0.18 logMAR and 0.16 ± 0.23 logMAR in the ICL and IPCL groups, respectively (p = 0.30). No eye lost CDVA in either group. By AS-OCT, the mean vault was 335.33 ± 165.83 μm and 532.64 ± 167.25 μm in the ICL and IPCL groups, respectively (p = 0.006). By UBM, the mean vault was 355.6 ± 136.6 μm and 509.3 ± 180.79 μm in the ICL and IPCL groups, respectively (p = 0.041).ConclusionsICL and IPCL offer similar refractive and clinical outcomes. IPCL tends to display a more consistent vault with less variation from one patient to another.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1585-1592"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}