European Journal of Ophthalmology最新文献

{"title":"The presence of stem cells in the human lacrimal drainage system: A proof of principle study.","authors":"Tejaswini Pingali, Dilip K Mishra, Vivek Singh, Mohammad Javed Ali","doi":"10.1177/11206721251333826","DOIUrl":"10.1177/11206721251333826","url":null,"abstract":"<p><p>PurposeTo investigate the presence of stem cells within the lacrimal drainage system.MethodsA prospective interventional case series where human lacrimal sac tissue biopsies were obtained from patients undergoing endoscopic dacryocystorhinostomy or a dacryocystectomy surgery at a tertiary care Dacryology Services. Histopathology, immunohistochemistry, and gene expression studies were performed to check the expression of several basic stem/progenitor specific genes - <i>Cd90, Cd105, Cd73</i>, <i>Abcb5, Abcg2,</i> and <i>P63α.</i>ResultsThe lacrimal sac showed positive expression of general stem cell markers (ABCB5, ABCG2, and P63<i>α)</i> and mesenchymal stem cell-specific markers <i>(CD73, CD90, CD105)</i> using transcriptional and immunolocalization studies<i>.</i> Interestingly, CD73 and CD105 double-positive cells and CD73 and CD90 double-positive cells (specific markers for mesenchymal stem cells) were noted in the lacrimal sac stroma and were confirmed not to be vascular endothelial cells.ConclusionThe present study is proof of the principle of the presence of a wide range of stem cell markers within the human lacrimal sac. This study could serve as a foundation for investigating the stem cells and characterizing them further to better understand the lacrimal drainage disorders.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1795-1802"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the novel role of ChatGPT-4 in addressing corneal ulcer queries: An AI-powered insight.","authors":"Bharat Gurnani, Kirandeep Kaur, Prasanth Gireesh, Logesh Balakrishnan, Chitaranjan Mishra","doi":"10.1177/11206721251337290","DOIUrl":"10.1177/11206721251337290","url":null,"abstract":"<p><p>PurposeChatGPT-4, a natural language processing-based AI model, is increasingly being applied in healthcare, facilitating education, research, and clinical decision-making support. This study explores ChatGPT-4's capability to deliver accurate and detailed information on corneal ulcers, assessing its application in medical education and clinical decision-making.MethodsThe study engaged ChatGPT-4 with 12 structured questions across different categories related to corneal ulcers. For each inquiry, five unique ChatGPT-4 sessions were initiated, ensuring that the output was not affected by previous queries. A panel of five ophthalmology experts including optometry teaching and research staff assessed the responses using a Likert scale (1-5) (1: very poor; 2: poor; 3: acceptable; 4: good; 5: very good) for quality and accuracy. Median scores were calculated, and inter-rater reliability was assessed to gauge consistency among evaluators.ResultsThe evaluation of ChatGPT-4's responses to corneal ulcer-related questions revealed varied performance across categories. Median scores were consistently high (4.0) for risk factors, etiology, symptoms, treatment, complications, and prognosis, with narrow IQRs (3.0-4.0), reflecting strong agreement. However, classification and investigations scored slightly lower (median 3.0). Signs of corneal ulcers had a median of 2.0, showing significant variability. Of 300 responses, 45% were rated 'good,' 41.7% 'acceptable,' 10% 'poor,' and only 3.3% 'very good,' highlighting areas for improvement. Notably, Evaluator 2 gave 35 'good' ratings, while Evaluators 1 and 3 assigned 10 'poor' ratings each. Inter-evaluator variability, along with gaps in diagnostic precision, underscores the need for refining AI responses. Continuous feedback and targeted adjustments could boost ChatGPT-4's utility in delivering high-quality ophthalmic education.ConclusionChatGPT-4 shows promising utility in providing educational content on corneal ulcers. Despite the variance in evaluator ratings, the numerical analysis suggests that with further refinement, ChatGPT-4 could be a valuable tool in ophthalmological education and clinical support.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1531-1541"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging and functional outcomes of choroidal metastases from non-small cell lung cancer treated with targeted therapy.","authors":"Giuliano Gualandi, Francesco Romano, Francesca Lamanna, Chiara Preziosa, Giovanni Staurenghi, Marco Pellegrini","doi":"10.1177/11206721251337129","DOIUrl":"10.1177/11206721251337129","url":null,"abstract":"<p><p>PurposeTo evaluate the long-term outcomes of next-generation tyrosine kinase inhibitor (TKI) therapy in patients with choroidal metastases (CMs) secondary to non-small cell lung cancer (NSCLC).Major FindingsThis case series includes five eyes from three patients with stage IV NSCLC and CMs. All patients presented with unilateral visual loss, though two exhibited bilateral choroidal lesions on multimodal imaging, including fundus photography, dye-based angiography, optical coherence tomography (OCT), and ultrasonography. Systemic evaluation confirmed ALK-rearranged NSCLC (case 1) and EGFR-mutated NSCLC (cases 2 and 3), leading to first-line treatment with Alectinib and Osimertinib, respectively. Within months of therapy initiation, significant anatomical and visual improvements were noted, with complete lesion resolution and photoreceptor restoration by 6 months. At final follow-up (24-36 months), high-resolution OCT showed residual granularity in the outer retinal layers, while OCT angiography (OCTA) revealed persistent choriocapillaris flow voids. Microperimetry demonstrated distinct functional alterations based on lesion location.ConclusionsThis series highlights favorable long-term outcomes in NSCLC patients with CMs treated with next-generation TKIs. It underscores the value of multimodal imaging and functional assessments in monitoring disease progression and treatment response, emphasizing the importance of early targeted therapy in optimizing visual outcomes.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP41-NP47"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative optical coherence tomography-assisted superficial keratectomy: A novel surgical technique for Salzmann nodular degeneration.","authors":"Alfredo Borgia, Matteo Airaldi, Nardine Menassa, Stephen Kaye, Vito Romano","doi":"10.1177/11206721251346278","DOIUrl":"10.1177/11206721251346278","url":null,"abstract":"<p><p>PurposeTo describe a technique for Salzmann Nodule removal assisted by Microscope-Integrated Intraoperative Optical Coherence Tomography (iOCT).MethodsThe study describes a novel approach utilizing iOCT for enhanced visualization and accurate dissection of difficult-to-see nodules, while clarifying their relation to anterior stromal haze.ResultsThis method leverages iOCT for effective nodule identification and removal, ensuring minimal disruption to surrounding tissue. It provides real-time feedback on dissection depth, facilitating precise excision without extensive keratectomy, and is particularly beneficial for surgeons with limited experience or in cases of reduced visibility.ConclusionsUtilizing iOCT during superficial keratectomy for Salzmann Nodular Degeneration allows for precise detection and removal of degenerated nodules. iOCT- guided keratectomy allows the corneal surgeon to preserve surrounding healthy corneal tissue and improves surgical results in Salzmann Nodular Degeneration.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1938-1941"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of internal limiting membrane peeling on surgical outcomes in diabetic tractional retinal detachment.","authors":"Serhat Ermis, Ece Ozal, Murat Karapapak, Idil Celen Arabaci, Sadık Altan Ozal","doi":"10.1177/11206721251355502","DOIUrl":"10.1177/11206721251355502","url":null,"abstract":"<p><p>PurposeThis study aimed to evaluate the anatomical and functional outcomes of internal limiting membrane (ILM) peeling during pars plana vitrectomy (PPV) in patients with tractional retinal detachment (TRD) secondary to proliferative diabetic retinopathy (PDR).MethodsPatients who underwent PPV without ILM peeling were classified as Group 1, and those with ILM peeling as Group 2. Due to the retrospective design, sixth-month postoperative results were considered final outcomes. Main outcome measures included development of epiretinal membrane (ERM), best corrected visual acuity (BCVA), and reoperation rates.ResultsA total of 108 eyes of 108 patients were analyzed. At the final visit, ERM developed in 20.3% (13/64) of patients in Group 1 compared to 4.6% (2/44) in Group 2 (<i>p</i> = 0.02). Final BCVA was similar between groups (<i>p</i> = 0.603). Reoperation rates were 31.2% (20/64) in Group 1 and 20.4% (9/44) in Group 2 (<i>p</i> = 0.232). Reoperation due to ERM was necessary in 7 patients in Group 1, whereas no patients in Group 2 required surgery for ERM (<i>p</i> = 0.023).ConclusionILM peeling during PPV in patients with TRD secondary to PDR significantly reduces ERM formation and improves anatomical outcomes. However, ILM peeling does not appear to affect the final visual acuity or overall reoperation rate.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1833-1841"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144583450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the quality and diagnostic accuracy of patient self-generated photographs used in oculoplastic virtual clinics.","authors":"Gabriella Guevara, Mumta Kanda, Hardeep Kandola, Laxmi Raja, Swan Kang","doi":"10.1177/11206721251325276","DOIUrl":"10.1177/11206721251325276","url":null,"abstract":"<p><p>BackgroundA barrier to video consultation in oculoplastics is visualising pathology too small for video resolution. Patient self-generated photographs, which is well-documented in teledermatology but not in oculoplastics, may provide a solution.PurposeTo assess the quality and diagnostic accuracy of patient self-generated photographs of presumed benign eyelid pathology.Methods300 patients with suspected benign lid lesions emailed self-captured photographs that were reviewed by two independent reviewers for quality, focussing, and lighting. The photographs were used in a virtual clinic alongside video consultation. Accuracy of virtual clinic diagnosis was measured by comparison to biopsy or in-person diagnosis where available.Results895 photographs were submitted. 84.5% of these were graded as excellent or adequate quality and there was no statistical difference in image quality based on patient age. Concordance between observers for quality of photographs, measured using Cohen's kappa, was k = 0.77 (<i>P</i> = <0.01). Virtual clinic diagnosis was verified in 236 (78.7%) patients by biopsy or in-person review. Correct diagnosis was made in 80.5%. 99.1% of benign lesions were correctly identified as low-risk, 50% of pre-malignant lesions were identified as suspicious, and 100% of malignant lesions were correctly identified as cancerous.ConclusionsPatients of all ages can provide adequate quality photographs that can aid video consultations for benign lid lesions. We still recommend in-person review where suspicious features are present, or photo quality is suboptimal.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1803-1809"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the overlooked risk: Ocular health and alterations in women with polycystic ovary syndrome.","authors":"Harshita Pandey, Neha Sharma, Kritika, Md Aftab Alam","doi":"10.1177/11206721251337584","DOIUrl":"10.1177/11206721251337584","url":null,"abstract":"<p><p>BackgroundPolycystic Ovary Syndrome is well known to cause various metabolic changes in the body; however, changes in the ocular surface are not fully understood or well-described in the existing literature. Hormonal disturbances resulting from PCOS may affect multiple ocular tissues, including the posterior segment, lacrimal and meibomian glands, cornea, and conjunctiva.ObjectiveThis paper aims to summarize the current knowledge and research regarding ocular alterations related to PCOS.MethodA comprehensive review of the existing literature was conducted by searching multiple databases, including Scopus, PubMed, and Google Scholar. Keywords such as \"Polycystic Ovary Syndrome,\" \"PCOS,\" \"ocular surface,\" \"dry eye,\" \"meibomian gland dysfunction,\" and \"ocular changes\" were used. Relevant case reports and clinical studies were included to provide a comprehensive understanding of the ocular implications of PCOS.ResultsAmong the ocular changes associated with PCOS, dry eyes are the most common source of irritation and discomfort in affected individuals. Recognizing this association is crucial for eye care practitioners.ConclusionIdentifying the link between PCOS and dry eyes enables practitioners to develop personalized management plans for individuals with PCOS, potentially improving their eye health and comfort in longer run. When necessary, further evaluation or referral may be required for patients with PCOS-related ocular symptoms.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1875-1882"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprachoroidal injection of a dexamethasone implant in a case of secondary macular oedema.","authors":"Pedro Neves","doi":"10.1177/11206721251337634","DOIUrl":"10.1177/11206721251337634","url":null,"abstract":"<p><p>BackgroundNon-infectious uveitis (NIU) is a common ocular inflammation that frequently leads to Macular oedema (MO). MO can cause irreversible tissue damage and permanent visual impairment. Dexamethasone implant is approved for intravitreal injection (IV) in the treatment of MO. Despite its proven efficacy, IV poses risks of complications. Recently, suprachoroidal injection has emerged as a novel strategy for targeted drug delivery to the posterior segment of the eye, reducing the risk of complications.Case presentationA 70-year-old woman with no history of diabetes underwent left eye cataract surgery complicated by a capsular rupture and vitreous prolapse, which resulted in the patient becoming aphakic. Later, ophthalmic examination revealed a cystoid MO secondary to a posterior postoperative NIU. Since IV injection of triamcinolone had minimal visual benefit and due to the contraindication of IV cortisone implants, a dexamethasone implant was injected via the suprachoroidal injection, with additional intravitreal triamcinolone. Functional and anatomical recovery was observed after the procedure, with improved visual acuity and no ocular hypertension.ConclusionOur study describes a successful case of dexamethasone implant administered via suprachoroidal space, with no complications and a possible increased effectiveness when compared with intravitreal triamcinolone.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP69-NP72"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence-based assessment of imaging biomarkers in epiretinal membrane surgery.","authors":"Cesare Mariotti, Lorenzo Mangoni, Alessio Muzi, Michele Fella, Veronica Mogetta, Giacomo Bongiovanni, Clara Rizzo, Jay Chhablani, Edoardo Midena, Marco Lupidi","doi":"10.1177/11206721251337139","DOIUrl":"10.1177/11206721251337139","url":null,"abstract":"<p><p>PurposeThis study investigated the applicability of a validated AI-algorithm for analyzing different retinal biomarkers in eyes affected by epiretinal membranes (ERMs) before and after surgery.MethodsA retrospective study included 40 patients surgically treated for ERMs removal between November 2022 and January 2024. Pars plana vitrectomy with ERM/ILM peeling was performed by a single experienced surgeon. A validated AI algorithm was used to analyze OCT scans, focusing on intraretinal fluid (IRF) and subretinal fluid (SRF) volumes, external limiting membrane (ELM) and ellipsoid zone (EZ) interruption percentages and hyper-reflective foci (HRF) counts.ResultsPostoperative best corrected visual acuity (BCVA) significantly improved (<i>p</i> < 0.01), and central macular thickness (CMT) decreased from 483.61 ± 96.32 to 386.82 ± 94.86 µm (<i>p</i> = 0.001). IRF volume reduced from 0.283 ± 0.39 mm³ to 0.142 ± 0.27 mm³ (<i>p</i> = 0.036) particularly in the central 1 mm-circle. SRF, HRF and EZ/ELM interruption percentages exhibited no significant differences (<i>p</i> > 0.05). Significant correlations (<i>p</i> < 0.05) were found between preoperative BCVA and postoperative BCVA (<i>r</i> = 0.45); CMT reduction and postoperative BCVA (<i>r</i> = 0.42), preoperative IRF and Visual Recovery (<i>r</i> = -0.48), ELM and EZ interruption and visual recovery (<i>r</i> = -0.43 and <i>r</i> = -0.47 respectively). Multivariate analysis demonstrated that fluid distribution, especially in the central subfield, correlated with BCVA recovery (R2 = 0.38; <i>p</i> < 0.05; Pillai's Trace = 0.79).ConclusionThe study highlights AI's potential in quantifying OCT biomarkers in ERMs surgery. The findings suggest that improved BCVA is associated with reduced CMT, IRF, and redistribution of IRF towards the periphery. EZ and ELM integrities remain crucial prognostic factors, emphasizing the importance of the preoperative analysis.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1542-1553"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular hypertension caused by elevated episcleral venous pressure following arteriovenous fistula embolization.","authors":"Khalatyan Garik, Lemmens Sophie, Loubet Antoine, Otjacques Loic, Bourguignon Gen-Hua, Marinescu Cristina, Pourjavan Sayeh","doi":"10.1177/11206721251338707","DOIUrl":"10.1177/11206721251338707","url":null,"abstract":"<p><p>Increased intraocular pressure due to elevated episcleral venous pressure is a recognized complication associated with arteriovenous fistulas, which typically form between the carotid artery and the cavernous sinus. We report a case of a patient who developed paradoxical worsening syndrome a few days after he underwent a two-staged transarterial embolization procedure of a left sided ethmoidal arteriovenous fistula. The patient presented with signs of elevated episcleral venous pressure leading to intraocular hypertension caused by the iatrogenic partial obstruction of the left superior ophthalmic vein.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP13-NP15"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}