European Journal of Ophthalmology最新文献_第6页

Clinical characteristics and outcomes of primary orbital lymphoma. 原发性眼眶淋巴瘤的临床特点及预后。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-29 DOI: 10.1177/11206721251338705

Kenny Y Wang, B Michelle Kim, Caroline Y Yu, Grant M Welk, Robert A Churchill, Launia J White, David O Hodge, Lauren A Dalvin, Andrea A Tooley

{"title":"Clinical characteristics and outcomes of primary orbital lymphoma.","authors":"Kenny Y Wang, B Michelle Kim, Caroline Y Yu, Grant M Welk, Robert A Churchill, Launia J White, David O Hodge, Lauren A Dalvin, Andrea A Tooley","doi":"10.1177/11206721251338705","DOIUrl":"10.1177/11206721251338705","url":null,"abstract":"PurposeTo describe the clinical characteristics, histopathologic subtype distribution, treatment, and outcomes of patients with primary orbital lymphoma.Major FindingsThere were 126 biopsy-confirmed cases of primary orbital lymphoma, with 81 (64.3%) female and 110 (87.3%) white. The average age at diagnosis was 62.7 ± 13.9 years. There were 26 (20.6%) cases with bilateral involvement. The most frequent lymphoma subtype was MALT lymphoma (N = 76, 60.3%), followed by diffuse large B-cell lymphoma (N = 18, 14.3%) and follicular lymphoma (N = 12, 9.5%). Prognosis was generally favorable, as local recurrence occurred in only 14 (11.1%) patients and final best corrected visual acuity (BCVA) loss of >1 line was seen in 30 (28.0%) patients. Bilateral lymphoma and advanced stage (Ann Arbor Stage III or IV) at presentation were associated with increased risk of local recurrence (p = 0.0025, p = 0.049). Improved disease-specific survival was associated with diagnosis at Stage I or II (p = 0.013), MALT subtype (p = 0.034), or lack of chemotherapy requirement as primary treatment (p = 0.0073).ConclusionsIn this single center academic cohort, MALT lymphoma subtype was most common. Overall orbital recurrence frequency was low, and bilateral lymphoma and advanced stage were associated with increased risk of local recurrence. MALT lymphoma subtype was associated with improved disease-specific survival. Long-term follow-up showed that most patients retained good visual acuity in the affected eye(s).","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1776-1785"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143963427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the retinal segmentation analysis in patients with clinically unilateral pseudoexfoliation syndrome. 临床单侧假性脱落综合征患者视网膜分割分析的比较。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-17 DOI: 10.1177/11206721251334163

Serkan Akkaya, Umay Güvenç, Ayşe Balıkçı, Gülizar Demirok, Güner Özkan, Selma Uzman, Naci Ertürk, Ayşe Burcu

{"title":"Comparison of the retinal segmentation analysis in patients with clinically unilateral pseudoexfoliation syndrome.","authors":"Serkan Akkaya, Umay Güvenç, Ayşe Balıkçı, Gülizar Demirok, Güner Özkan, Selma Uzman, Naci Ertürk, Ayşe Burcu","doi":"10.1177/11206721251334163","DOIUrl":"10.1177/11206721251334163","url":null,"abstract":"PurposeTo compare the thicknesses of each retinal layer in patients with clinically unilateral pseudoexfoliation syndrome (XFS) versus unaffected fellow eyes and healthy age-matched controls.MethodsIn this cross-sectional study, a complete ophthalmologic evaluation, including intraocular pressure (IOP) measurement, was performed in 40 patients with unilateral XFS-affected and 43 healthy controls. After confirming that fellow eyes were clinically unaffected, all eyes underwent the retinal layer segmentation analysis using enhanced depth imaging spectral-domain optical coherence tomography (EDI SD-OCT). The thickness maps were divided into nine subfields (i.e., 1-mm, 3-mm, and 6-mm grids) using the Early Treatment Diabetic Retinopathy Study (ETDRS) and were extracted from the software to compare the groups.ResultsIn the 1-mm central subfield, thicknesses of the ganglion cell layer (GCL), inner plexiform layer (IPL), and inner retinal layer (IRL) were significantly reduced both in XFS-affected and fellow eyes than in controls. Additionally, the thicknesses of the inner nuclear layer (INL) and outer plexiform layer (OPL) were significantly reduced in fellow eyes compared to controls. Comparison of XFS-affected versus fellow eyes in the 1-mm central subfield showed no significant differences in GCL, IPL, IRL, INL, and OPL thicknesses (p > 0.05, for all; Tukey HSD test). In ETDRS subfields, 3-mm temporal and 3-mm inferior IPL thicknesses of fellow eyes and 6-mm temporal INL thickness in XFS-affected eyes were reduced compared to controls (p < 0.05, for all).ConclusionIn clinically unilateral XFS, the consequential thinning of retinal layers in the fellow eye accompanies the significant thinning of retinal layers in the affected eye.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1637-1646"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Are blood platelet parameters associated with retinal nerve fiber layer thickness Among healthy young adults? a university-based study. 健康年轻人血小板参数与视网膜神经纤维层厚度有关吗？以大学为基础的研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-21 DOI: 10.1177/11206721251335375

Dan-Lin Li, Min-Xin Liu, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Ya-Jie Zheng, Yu Qin, Gang Liang, Chen-Wei Pan

{"title":"Are blood platelet parameters associated with retinal nerve fiber layer thickness Among healthy young adults? a university-based study.","authors":"Dan-Lin Li, Min-Xin Liu, Zhi-Jian Yin, Yue-Zu Li, Rong Ma, Ya-Jie Zheng, Yu Qin, Gang Liang, Chen-Wei Pan","doi":"10.1177/11206721251335375","DOIUrl":"10.1177/11206721251335375","url":null,"abstract":"BackgroundPlatelet parameters have been linked with glaucomatous optic neuropathy but whether they were associated with retinal nerve fiber layer (RNFL) thickness among healthy individuals remains unclear. We aim to determine the relationship between different platelet parameters and RNFL thickness in healthy university students.MethodsThe Dali University Students Eye Health Study is a university-based, cross-sectional study in southwestern China in 2021. RNFL thickness was measured automatically using an optical coherence tomography scanner. An automated hematology analyzer was used to analyze the platelet parameters including platelet (PLT) count, platelet distribution width (PDW), mean platelet volume (MPV) and plateletcrit (PCT). Linear regression models and generalized additive models were established to examine the associations of platelet parameters with RNFL thickness.ResultsA total of 1905 participants with valid RNFL thickness and platelet parameters data were included in the current analysis. Per unit increase in the levels of MPV and PDW was associated with a decrease of 0.74 μm (P = 0.04) and 0.35 μm (P = 0.04) in RNFL thickness in multivariable-adjusted model. Subgroup analyses indicated that the association between MPV and RNFL thickness was present in male students. A non-linear trend in the association of MPV with RNFL thickness were observed (P = 0.04).ConclusionIncreased levels of MPV and PDW were associated with thinner RNFLs among university students, suggesting that the platelet parameters, a simple, global, and economical markers, have the potentials to be an additional valuable biomarker for predicting the change of RNFL thickness and onset of RNFL-related nerve diseases in late adulthood.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1767-1775"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing accuracy, readability & reliability of AI-generated patient leaflets on Descemet membrane endothelial keratoplasty. 评估人工智能生成的网膜内皮角膜移植术患者小叶的准确性、可读性和可靠性。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-28 DOI: 10.1177/11206721251367562

Bnar Massraf, Ka Kiu Cheris Chan, Nikhil Jain, Jesse Panthagani

{"title":"Assessing accuracy, readability & reliability of AI-generated patient leaflets on Descemet membrane endothelial keratoplasty.","authors":"Bnar Massraf, Ka Kiu Cheris Chan, Nikhil Jain, Jesse Panthagani","doi":"10.1177/11206721251367562","DOIUrl":"https://doi.org/10.1177/11206721251367562","url":null,"abstract":"PurposeThis study assessed the readability, reliability and accuracy of patient information leaflets on Descemet Membrane Endothelial Keratoplasty (DMEK), generated by seven large language models (LLMs). The aim was to determine which LLM produced the most patient-friendly, comprehensible and evidence-based leaflet, measured against a leaflet written by clinicians from a tertiary centre.MethodsEach LLM was given the prompt, \"Make a patient information leaflet on Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.\" Readability metrics (FKG, FRE, ARI, Gunning Fog), reliability metrics (DISCERN, PEMAT), misinformation detection and reference analysis were recorded for each response. A weighted scoring system normalised results on a 0-100% scale.ResultsThe clinician-generated leaflet scored the highest (92%). Claude 3.7 Sonnet had the top LLM score (77.8%), with strong readability and referencing. ChatGPT-4o followed closely (70.9%) but lacked references. Moderate scores for DeepSeek-V3, Perplexity AI and Google Gemini 2.0 Flash. ChatGPT-4 and Microsoft CoPilot scored the lowest due to limited reliability and misinformation.ConclusionsLLMs show promise in generating patient education material but vary in reliability and accuracy. Claude 3.7 Sonnet was the best performing LLM, though none matched in quality to the clinician-generated leaflet. LLM-generated leaflets therefore require clinician oversight before safe clinical use.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251367562"},"PeriodicalIF":1.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cataract global burden of adolescents and young adults between 1990 and 2021: Analyses of the Global Burden of Disease Study 2021. 1990年至2021年间青少年和青壮年白内障全球负担：2021年全球疾病负担研究分析

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-21 DOI: 10.1177/11206721251370911

Lobsang Tshedron, Zijing Li

{"title":"Cataract global burden of adolescents and young adults between 1990 and 2021: Analyses of the Global Burden of Disease Study 2021.","authors":"Lobsang Tshedron, Zijing Li","doi":"10.1177/11206721251370911","DOIUrl":"https://doi.org/10.1177/11206721251370911","url":null,"abstract":"PurposeTo investigate the trend of cataract burden in individuals aged 15 to 39 years from 1990 to 2021.MethodsThis cross-sectional study leveraged data from the Global Burden of Disease Study 2021. The analysis included prevalence and disability-adjusted life years (DALYs) rates, along with the associated estimated annual percentage changes (EAPCs), assessed at the global level and categorized by sex, sociodemographic index (SDI), geographic region, and country.ResultsIn 2021, the global age-standardized prevalence rate (ASPR) was 51.095 per 100,000. From 1990 to 2021, the ASPR decreased by 5.615% (95% UI, -12.772 to 1.747%), with an EAPC of -0.379 (95% CI, -0.442 to -0.316). The age-standardized DALYs rate (ASDR) in 2021 was 5.541 per 100,000, decreasing by 20.498% (95% UI, -25.969 to -14.292), with an EAPC of -0.959 (95% CI, -1.041 to -0.877). The reductions in EAPC for ASPR and ASDR were more pronounced in males than in females. The high-SDI region exhibited the greatest increase in the EAPC of ASPR (0.219, 95% UI, 0.096 to 0.342) and generally remained stable in the EAPC of ASDR (0.024, 95% UI, -0.135 to 0.183). However, the low-middle-SDI region showed the greatest decrease in ASPR (EAPC: -1.246, 95% UI, -1.325 to -1.167) and ASDR (EAPC: -1.889, 95% UI, -1.974 to -1.804). Central Europe had the sharpest rise in both ASPR and ASDR among the 21 geographic regions, while South Asia saw the steepest decline. At the country level, the Central African Republic exhibited the largest increase, while Equatorial Guinea showed the greatest decrease in both ASPR and ASDR.ConclusionOver the past 32 years, the global burden of cataracts among adolescents and young adults has decreased; however, it remains a significant public health concern worldwide. Cost-effective and targeted strategies are needed to alleviate this burden.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251370911"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute corneal hydrops secondary to acquired syphilis. 继发于获得性梅毒的急性角膜积水。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-21 DOI: 10.1177/11206721251370906

Anchal Thakur, Divya Challa, Archana Angrup, Dipankar De, Sonam Yangzes, Chintan Malhotra, Amit Gupta

引用次数: 0

Role of cognitive function in the reliability and results of standard automated perimetry. 认知功能在标准自动验光的可靠性和结果中的作用。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-21 DOI: 10.1177/11206721251369918

Joel Pitkänen, Johanna Liinamaa, Ville Saarela

{"title":"Role of cognitive function in the reliability and results of standard automated perimetry.","authors":"Joel Pitkänen, Johanna Liinamaa, Ville Saarela","doi":"10.1177/11206721251369918","DOIUrl":"https://doi.org/10.1177/11206721251369918","url":null,"abstract":"PurposeTo investigate the association between cognitive function and the results and reliability of standard automated perimetry (SAP) in a middle-aged birth cohort.MethodsIn this cross-sectional analysis of the prospective birth cohort, the reliability and performance of SAP were evaluated in relation to grade point average (GPA), educational attainment, and scores on the Paired Associates Learning (PAL) test among participants of the Northern Finland Birth Cohort Eye Study.ResultsHigher educational level, higher GPA, and fewer errors on the PAL test were consistently associated with better reliability and performance in SAP. However, the observed correlation coefficients were low, and differences between group comparisons were modest, accounting for only a small proportion of the variance in SAP outcomes.ConclusionWhile greater cognitive ability is positively associated with SAP performance and reliability, its impact is minimal and unlikely to be clinically significant. Further studies are warranted to determine whether higher cognitive function facilitates glaucoma diagnosis and monitoring through more reliable SAP results, or conversely, whether it may obscure glaucomatous damage by enhancing test performance beyond what is typical.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251369918"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating surgical experience in trabeculectomy: Insights from a single-surgeon learning curve. 评估小梁切除术的手术经验：来自单个外科医生学习曲线的见解。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-21 DOI: 10.1177/11206721251370056

Alicja Strzalkowska, Piotr Strzalkowski, Leon Daniello, Esther M Hoffmann, Norbert Pfeiffer, Alexander K Schuster

{"title":"Evaluating surgical experience in trabeculectomy: Insights from a single-surgeon learning curve.","authors":"Alicja Strzalkowska, Piotr Strzalkowski, Leon Daniello, Esther M Hoffmann, Norbert Pfeiffer, Alexander K Schuster","doi":"10.1177/11206721251370056","DOIUrl":"https://doi.org/10.1177/11206721251370056","url":null,"abstract":"PurposeThe aim of our study was to evaluate the outcome of trabeculectomy with respect to surgeon's experience and to explore additional contributing factors.MethodsThis retrospective study was conducted analyzing consecutive single-surgeon cases from October 2019 to June 2022 receiving TE with mitomycin C. Eyes were categorized into five groups based on surgeon experience: E1 for the first 50 TEs, E2 for 51-100, E3 for 101-150, E4 for 151-200, E5 for 201-300. Complete success at one year was defined as an IOP <18 mmHg and 20%-IOP reduction without glaucoma eye drops and revision surgeries.Results300 eyes were included (mean age 68.8 ± 13.0 years, 58.3% female). 55.7% had primary open-angle glaucoma. The baseline IOP was 23.4 ± 8.7 mmHg with 3.0 ± 0.9 different antiglaucomatous medication. After 12 months, the complete success for E1 to E5, it was 83.0%, 86.7%, 87.4%, 75.3% and 79.1% (p < 0.0001) with IOP 12.8 ± 6.1, 12.8 ± 6.3, 11.5 ± 4.6, 12.9 ± 6.5, 12.9 ± 4.7 mmHg while there was a higher number of NTG cases in E4 and E5 (p = 0.04).ConclusionsEven a novice surgeon can achieve a good surgical outcome within the first 50 trabeculectomy under the guidance of an experienced surgeon. When comparing surgical results over time, it is important to incorporate case entity and severity.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251370056"},"PeriodicalIF":1.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical features and refractive profile of surgical patients with dissociated vertical deviation. 游离性垂直偏差手术患者的临床特征及屈光表现。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-19 DOI: 10.1177/11206721251367570

Mohamad Reza Akbari, Masoud Khorrami-Nejad, Aiham Ali Mohammed, Foroozan Narooie-Noori, Reza Yousefi, Saba Javadi

{"title":"Clinical features and refractive profile of surgical patients with dissociated vertical deviation.","authors":"Mohamad Reza Akbari, Masoud Khorrami-Nejad, Aiham Ali Mohammed, Foroozan Narooie-Noori, Reza Yousefi, Saba Javadi","doi":"10.1177/11206721251367570","DOIUrl":"10.1177/11206721251367570","url":null,"abstract":"BackgroundTo report the deviation type, visual and refractive characteristics of patients with dissociated vertical deviation (DVD) requiring unilateral or bilateral strabismus surgery.MethodsThis study included 180 patients with DVD who underwent unilateral or bilateral strabismus surgery at Farabi Eye Hospital.Age, refractive error (RE), Corrected distance visual acuity (CDVA), strabismus angle, presence of amblyopia, and postoperative outcome.ResultsThirty-eight patients were in unilateral (78.9% bilateral) group. In the unilateral group, CDVA was significantly worse in surgical eyes versus fellow eyes (P < .001). The mean spherical equivalent in surgical eyes was insignificantly hyperopic than fellow eyes (P = 0.354). The mean angle of DVD was greater at distance than near (P < .05). Furthermore, the most prevalent type was \"DVD plus horizontal deviation\" (47.4%), followed by pure DVD (23.7%), \"combined DVD, hypertropia (HT) and horizontal deviation\" (13.2%), and \"HT plus DVD\" (15.8%). CDVA in cases needing bilateral surgery in the right and left eye were 0.91 ± 0.17 and 0.90 ± 110.17, respectively.In the bilateral group, RE components were similar between eyes but lower than surgical eyes in patients with unilateral surgery (P < .05). Moreover, the mean angle of DVD was higher at a distance compared to near.The most prevalent type was \"DVD plus horizontal deviation\" (64.1%), followed by pure DVD (18.3%), \"combined DVD, HT and horizontal deviation\" (13.4%), and \"HT plus DVD\" (4.2%).ConclusionsThe study highlighted significant differences in VA, RE, and prevalence of amblyopia between the two groups.Furthermore, the varying types of coexisting deviations observed in unilateral and bilateral surgery cases emphasize the importance of personalized treatment approaches for patients with DVD.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251367570"},"PeriodicalIF":1.4,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of malnutrition on pupillary responses in pediatric population. 营养不良对儿童瞳孔反应的影响。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-08-17 DOI: 10.1177/11206721251367568

Dilara Özkoyuncu Kocabas, Fuat Yavrum, Elmas Yüksel Şükün, Begüm Yavrum

{"title":"Impact of malnutrition on pupillary responses in pediatric population.","authors":"Dilara Özkoyuncu Kocabas, Fuat Yavrum, Elmas Yüksel Şükün, Begüm Yavrum","doi":"10.1177/11206721251367568","DOIUrl":"https://doi.org/10.1177/11206721251367568","url":null,"abstract":"PurposeTo investigate the effect of nutritional status on pupillary responses in children aged 5 to 18 years.MethodsThis cross-sectional study comprised 92 eyes of malnourished children and 80 eyes of age- and gender-matched healthy children based on BMI Z-score. Serum ferritin, hemoglobin, serum 25-hydroxyvitamin D, and vitamin B12 levels were recorded. Pupillary responses were taken using Sirius topography (CSO, Italy) with the automated pupillometry function. Static pupillometry consisted of pupil diameters at scotopic, mesopic, and photopic luminances. In dynamic pupillometry, the mean pupil dilation speed at the 10th second was calculated by dividing the distance by time in each 0.2 s period.ResultsNo significant difference was observed between the groups regarding age, gender, visual acuity, and spherical equivalent (p > 0.05). Mean hemoglobin, serum ferritin, serum 25-hydroxyvitamin D, and vitamin B12 levels were lower in malnourished children than healthy children (p < 0.001). The malnutrition group had lower mean pupil diameters under all luminance and higher speed of pupil dilation compared to the control group (p < 0.05). While malnutrition subgroups were similar in terms of pupil diameters under all luminance (p > 0.05), the speed of pupil dilation was significantly different between the groups (p = 0.024). BMI z-score was positively correlated with mesopic and photopic pupil diameter but also negatively correlated with the speed of pupil dilation (p < 0.05).ConclusionMalnourished children have smaller pupil diameters and higher speed of pupil dilation than healthy controls, indicating an autonomic impairment.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251367568"},"PeriodicalIF":1.4,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0