European Journal of Ophthalmology最新文献

{"title":"Subacute onset rhino-orbital mucormycosis caused by Cunninghamella in a Chinese leukemia patient: A case report and literature review.","authors":"Jianqin Shen, Yanhong Chen, Ying Chen, Hongguang Cui","doi":"10.1177/11206721241300202","DOIUrl":"10.1177/11206721241300202","url":null,"abstract":"<p><strong>Purpose: </strong>We herein report a case of subacute-onset rhino-orbital mucormycosis (ROM) in an acute leukemia patent caused by the rare but most lethal pathogenic fungus - Cunninghamella. To the best of our knowledge, this is the first case of ROM caused by Cunninghamella reported in China.</p><p><strong>Case description: </strong>A 50-year-old Chinese female with acute leukemia (M2 type) who, following the completion of two cycles of chemotherapy, began to exhibit naso-ocular symptoms. The patient was initially diagnosed with extramedullary leukemia. As the disease progressed, the patient began to develop specific black crust-like necrosis of the right eyelids. Following multidisciplinary treatment (MDT) consultation and tissue biopsy, the patient was finally diagnosed with a rare type of ROM caused by Cunninghamella infection. Although the mortality associated with Cunninghamella infection was significantly greater than that associated with infections caused by other Mucorales, the infection was eventually controlled through the adjustment of the antifungal drug regimen and timely surgical intervention.</p><p><strong>Conclusions: </strong>ROM infection with Cunninghamella is an extremely rare and fatal fungal infection, and early recognition and diagnosis of the disease is critical to the prognosis. The subacute nature of this case may have been a positive factor in the patient's preservation of life.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP44-NP48"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"Response to 'EBEI: A new index of eye bank efficiency'\".","authors":"Francesco Aiello, Gabriele Gallo Afflitto, Francesca Ceccarelli, Massimo Cesareo, Carlo Griffoni, Diego Ponzin, Carlo Nucci","doi":"10.1177/11206721241296751","DOIUrl":"10.1177/11206721241296751","url":null,"abstract":"","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP67"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to 'EBEI: A new index of eye bank efficiency'.","authors":"Aine O'Connor, Con Petsoglou, Pierre Georges, Chris Hodge","doi":"10.1177/11206721241296749","DOIUrl":"10.1177/11206721241296749","url":null,"abstract":"","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP63-NP64"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular thickness and visual acuity are characterized by a quadratic nonlinear relation in previously treated neovascular AMD eyes.","authors":"Enrico Borrelli, Giacomo Boscia, Francesco Gelormini, Federico Ricardi, Andrea Ghilardi, Paola Marolo, Guglielmo Parisi, Matteo Fallico, Marco Lupidi, Cesare Mariotti, Francesco Bandello, SriniVas Sadda, Michele Reibaldi","doi":"10.1177/11206721241265998","DOIUrl":"10.1177/11206721241265998","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the associations between visual acuity (VA) and retinal thickness in age-related macular degeneration (AMD) eyes treated with anti-vascular endothelial growth factor (VEGF) therapy.</p><p><strong>Methods: </strong>Sixty-eight patients with neovascular AMD (68 eyes) undergoing anti-VEGF therapy with two years of follow-up imaging data after the initiation of treatment were retrospectively included. Linear and nonlinear regression analyses with curve fitting estimation were performed to explore the relationship between visual acuity and OCT-based parameters at the 3-month and 24-month follow-up visits. Regression analyses were also performed between visual acuity and the retinal thickness deviation which was calculated as the absolute value of the difference between measured and normative retinal thickness values.</p><p><strong>Results: </strong>The VA was not associated with either foveal (R²= 0.011 and <i>p</i> = .401 at 3 months; R²= 0.032 and <i>p</i> = .142 at 24 months) or parafoveal (R²= 0.045 and <i>p</i> = .081 at 3 months; R²= 0.050 and <i>p</i> = .055 at 24 months) retinal thicknesses. Compared with the linear models, a quadratic function yielded a relative increase in the R² coefficients. Conversely, the VA was linearly associated with foveal retinal thickness deviation (R²= 0.041 and <i>p</i> = .037 at 24 months) and parafoveal retinal thickness deviation (R²= 0.062 and <i>p</i> = .040 at 3 months; R²= 0.088 and <i>p</i> = .014 at 24 months) values.</p><p><strong>Conclusions: </strong>Although there was no linear relationship between retinal thickness and VA, a weak but statistically significant linear relationship could be observed when a retinal thickness deviation was considered. This suggests that deviation-based parameters may be beneficial for structure-function correlations in the context of anti-VEGF therapy for neovascular AMD.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"650-659"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple medications and quality of life of Nigerians with primary open angle glaucoma.","authors":"Chinasa Anderline Nnubia, Sebastian Ndulue Ntuko Nwosu, Nonso Ejikeme Okpala, Akunne Ijeoma Apakama, Ifeanyi James Orji, Chizoba Udoka Uba-Obiano, Adaora Amaoge Onyiaorah","doi":"10.1177/11206721241272179","DOIUrl":"10.1177/11206721241272179","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the impact of multiple medications on the quality of life of primary open angle glaucoma (POAG) patients on medical treatment at Guinness Eye Centre Onitsha, Nigeria.</p><p><strong>Materials and methods: </strong>Adult patients diagnosed with POAG who were undergoing medical therapy were selected through systematic sampling. They were asked to provide information on socio-demographic background, the number and types of glaucoma medications they were using and any adverse effects encountered while using these medications. The patients' quality of life was assessed by utilizing the National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) and all patients completed ocular examination. Data analysis was with Statistical Package for Social Sciences (SPSS) version 23.</p><p><strong>Results: </strong>One hundred and seventy-one patients, aged 40-83 years, mean 59.1 ± 11.1 were studied; there were 79(46.2%) males and 92(53.8%) females. One hundred and nine (63.7%) patients were on multiple medications. Side effects of treatment increased with increasing number of medications. The mean quality of life score in monotherapy group and double therapy group were 89.3 ± 15.8 and 80.2 ± 21.1 respectively; while that in ≥ triple therapy group was 78.9 ± 18.8. This decrease in mean quality of life score with increasing number of medications was statistically significant in bivariate analysis (<i>P</i> < 0.01), however, multiple regression analysis showed that the number of medications did not significantly affect the quality of life scores after adjusting for confounding variables(<i>p</i> = 0.881).</p><p><strong>Conclusion: </strong>Among the patients studied, use of multiple medications, unlike visual acuity (VA) and severity of glaucoma, was not an independent predictor of quality of life.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"576-581"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular and adnexal injuries after two major earthquakes in Turkey on February 6, 2023.","authors":"Melike Şensoy, Nurettin Bayram, Eyupcan Sensoy, Kenan Sonmez","doi":"10.1177/11206721241272204","DOIUrl":"10.1177/11206721241272204","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to determine the forms of ocular and adnexal injuries and to examine the treatment modalities applied after two major earthquakes in Turkey on February 6, 2023.</p><p><strong>Methods: </strong>Following the earthquakes, the medical records of 34 patients admitted with emergency ophthalmic complaints to Hatay Training and Research Field Hospital and Etlik City Hospital were retrospectively reviewed. Of these patients, 35 eyes of 34 individuals diagnosed with earthquake-related ocular and adnexal injuries were included in the study. Demographic characteristics were recorded, including ocular and adnexal findings, treatment modalities, and postoperative complications.</p><p><strong>Results: </strong>Of the patients, 16 (47.1%) were female, and 18 (52.9%) were male. The mean age was 37.38 ± 17.3 years. The mean time from the earthquake to the first admission to the hospital was 3.82 ± 1.78 days. Initial and final best-corrected visual acuities (BCVA) were 0.54 ± 0.66 logMAR and 0.22 ± 0.41 logMAR, respectively (<i>p </i>= 0.0003). The initial and final BCVA of 2 eyes was no light perception. The most common forms of ocular/periocular injury associated with earthquakes were eyelid laceration (n:25, 71.4%) and orbital fracture (n:17, 48.6%). The most common accompanied systemic trauma was extremity/rib fractures (38.2). The most frequently performed surgery was the primary repair of the eyelid/canalicular (n:17, 48.6%).</p><p><strong>Conclusion: </strong>While earthquake-related ocular and adnexal traumas are relatively uncommon, understanding the specific injury types, promptly identifying cases requiring urgent intervention, and mastering effective treatment modalities are essential for minimizing the risk of severe permanent visual impairment in these patients.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"734-740"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular manifestations and outcomes of OPMD- a report from the national IsrOPMD registry.","authors":"Ori Mekiten, Alex Zvulunov, Guy Ben Simon, Hagit Charas, Merav Ben-David, Shahar Shelly, Lior Greenbaum, Amir Dori, Limor Benyamini, Dinah Zur, Niv Levi, Daphna Landau Prat, Ofira Zloto","doi":"10.1177/11206721241259145","DOIUrl":"10.1177/11206721241259145","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to describe the ocular manifestations, treatment, and prognosis of OPMD patients registered in the national Israel OPMD(IsrOPMD) registry.</p><p><strong>Methods: </strong>Data was prospectively collected from patients referred to the IsrOPMD registry from January 2022 to March 2023. This included patient demographics, medical and ocular history, eye exams, eyelid evaluations, visual field exams, and orthoptic evaluations.</p><p><strong>Results: </strong>30 patients (15 males, mean age 53 years) were treated in the ocular OPMD clinic, predominantly of Bukhari descent (86.6%). The mean visual acuity was 0.06 logMAR. Twenty-one patients (70%) had eye movement problem, mostly in horizontal gaze. 6(20%) patients' complaint about diplopia. Ptosis surgery was performed in 21(70%) patients, with 17(56.7%) patients underwent frontalis sling surgery and 4(13.3%) patients undergoing levator advancement. The mean Margin reflex distance (MRD1) improved post-surgery (2.28 mm vs. 1.58 mm), but 11(36.6%) patients required more than one ptosis surgery.</p><p><strong>Conclusions: </strong>The study contributes valuable insights into the ocular aspects of OPMD. It reveals that OPMD patients often experience a range of ocular symptoms, such as ptosis, abnormalities in eye movements, strabismus, and potentially diplopia, which can significantly impact their quality of life. The findings underscore the importance of regular ophthalmological follow-up for these patients to address these symptoms effectively. The study is significant in contributing to the limited but growing knowledge about the ocular manifestations of OPMD and the management of these symptoms to improve the quality of life for patients suffering from this condition.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"451-455"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avoid delaying vitrectomy by foregoing diagnostic testing if the intraocular foreign body is visible and endophthalmitis is incipient.","authors":"Robert E Morris, Vikram T Saini, Nicholas Tosi, Ferenc Kuhn, Mathew R Sapp, Matthew H Oltmanns","doi":"10.1177/11206721241297186","DOIUrl":"10.1177/11206721241297186","url":null,"abstract":"<p><strong>Introduction: </strong>Intraocular foreign bodies (IOFBs) are known to cause endophthalmitis at a high rate. Media opacity (corneal edema, cataract, vitreous hemorrhage) and the need for diagnostic testing often prevent timely recognition of an infection; the resulting treatment delay worsens the prognosis. We present a case in which direct visualization of a posterior-segment IOFB and the incipient endophthalmitis allowed foregoing further testing (computed tomography), shortening the time to sight-saving vitrectomy.</p><p><strong>Case description: </strong>A 16-year-old male presented 19 h after a hammering-related injury. The media remained clear, permitting recognition of a large area of purulent retinal infiltrate adjacent to the intravitreal IOFB. Within one hour the patient underwent comprehensive surgery (wound closure, vitrectomy, IOFB removal, and intravitreal antibiotic injection). The development of full-blown endophthalmitis was prevented, even though the vitreous culture yielded <i>Staphylococcus epidermidis</i>. Final visual acuity at one year was 20/30, with the retinal injury approaching to within 1 mm of the fovea.</p><p><strong>Conclusions: </strong>In opaque-media eyes with a suspected IOFB treatment delay is common, due to waiting for computed tomography (CT) - instead of ultrasonography, which can safely identify the IOFB in over 90% of cases. Expediting surgery is the best prophylaxis against post-presentation endophthalmitis. Our case highlights the benefits of early vitrectomy based on direct inspection of the IOFB alone; instant ultrasonography instead of a CT-caused delay may save eyes with infection developing behind media opacity.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP49-NP54"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomised study comparing performance and safety of Eyestil Plus^® vs Vismed Multi^® in moderate-to-severe dry eye syndrome patients.","authors":"P J Pisella, P Gain, B Cochener, S Baillif, L Kodjikian, C Creuzot-Garcher, D Touboul, M Gonzalvez, P Gabisson, S El Amali, D Galarreta, J Merayo Lloves, A Cano-Ortiz, R Ruiz Mesa, C Civiale, M G Mazzone, J Montero","doi":"10.1177/11206721241266874","DOIUrl":"10.1177/11206721241266874","url":null,"abstract":"<p><strong>Purpose: </strong>This clinical investigation compared the performance and safety of Eyestil Plus® (SIFI) and Vismed Multi® (TRB Chemedica) for reducing keratitis lesions in moderate-to-severe dry eye disease (DED) patients.</p><p><strong>Materials and methods: </strong>This was a randomised, double-blind, multicentre investigation. 96 adults (>18 years of age) with moderate-to-severe DED received Eyestil Plus® (<i>N</i> = 48) or Vismed Multi® (<i>n</i> = 48) 6 times daily for 3 months. The primary objective clinical performance after 1 month as global corneal and conjunctival staining scores. The secondary objectives were clinical performance after 3 months, tear film stability (tear break up time (TBUT), tear production (Schirmer test), patient-reported outcomes (PROs), investigator satisfaction, and safety.</p><p><strong>Results: </strong>96 participants were randomised to receive the clinical investigations' treatments, 82.3% of them were female and their mean age was 65.8 years. The non-inferiority of Eyestil Plus® for moderate-to-severe DED was demonstrated at 1 month. No statistical difference was found for any of the study's objectives: change at 1 and 3 months of the global corneal and conjunctival staining score (<i>p</i>-value = 0.506 and 0.661, respectively), change at 1 and 3 months (<i>p</i>-value = 0.538 and 0.302) for TBUT test; change at 3 months for Schirmer test (<i>p</i>-value = 0.540). There were no changes for PROs either. Investigator satisfaction was high for both products. 16.6% of the participants experienced adverse events.</p><p><strong>Conclusion: </strong>This clinical investigation showed the non-inferiority of Eyestil Plus® compared to Vismed Multi® regarding performance and safety in a moderate-to-severe DED population.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"482-491"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic retinopathy screening with confocal fundus camera and artificial intelligence - assisted grading.","authors":"A Piatti, C Rui, S Gazzina, B Tartaglino, F Romeo, R Manti, M Doglio, E Nada, C B Giorda","doi":"10.1177/11206721241272229","DOIUrl":"10.1177/11206721241272229","url":null,"abstract":"<p><strong>Purpose: </strong>Screening for diabetic retinopathy (DR) by ophthalmologists is costly and labour-intensive. Artificial Intelligence (AI) for automated DR detection could be a clinically and economically alternative. We assessed the performance of a confocal fundus imaging system (DRSplus, Centervue SpA), coupled with an AI algorithm (RetCAD, Thirona B.V.) in a real-world setting.</p><p><strong>Methods: </strong>45° non-mydriatic retinal images from 506 patients with diabetes were graded both by an ophthalmologist and by the AI algorithm, according to the International Clinical Diabetic Retinopathy severity scale. Less than moderate retinopathy (DR scores 0, 1) was defined as non-referable, while more severe stages were defined as referable retinopathy. The gradings were then compared both at eye-level and patient-level. Key metrics included sensitivity, specificity all measured with a 95% Confidence Interval.</p><p><strong>Results: </strong>The percentage of ungradable eyes according to the AI was 2.58%. The performances of the AI algorithm for detecting referable DR were 97.18% sensitivity, 93.73% specificity at eye-level and 98.70% sensitivity and 91.06% specificity at patient-level.</p><p><strong>Conclusions: </strong>DRSplus paired with RetCAD represents a reliable DR screening solution in a real-world setting. The high sensitivity of the system ensures that almost all patients requiring medical attention for DR are referred to an ophthalmologist for further evaluation.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"679-688"},"PeriodicalIF":1.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}