European Journal of Ophthalmology最新文献_第6页

Intraoperative optical coherence tomography for Ab externo PreserFlo MicroShunt in glaucoma surgery. 术中光学相干断层扫描在青光眼手术中的应用。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI: 10.1177/11206721251347813

Sharon Braudo, Joseph Sofaer, Rand Zaitar, David Zadok, Mordechai Goldberg

{"title":"Intraoperative optical coherence tomography for Ab externo PreserFlo MicroShunt in glaucoma surgery.","authors":"Sharon Braudo, Joseph Sofaer, Rand Zaitar, David Zadok, Mordechai Goldberg","doi":"10.1177/11206721251347813","DOIUrl":"10.1177/11206721251347813","url":null,"abstract":"PurposeThis study aims to introduce an innovative surgical technique for facilitating the insertion and precise positioning of the PreserFlo MicroShunt (PMS) using intraoperative optical coherence tomography (iOCT).MethodsiOCT was employed to determine the transscleral route, entry point into the anterior chamber (AC), trajectory of the PMS within the AC, and final intracameral and scleral positioning of the PMS. Intra- and postoperative outcomes and complications were evaluated.ResultsThis retrospective study included nine eyes of nine consecutive glaucoma patients who underwent PMS implantation using the new technique. All patients showed a significant reduction in intraocular pressure, without notable complications. In some cases, iOCT identified initial misplacements, enabling immediate intraoperative adjustments and successful repositioning, ensuring precise and safe implantation in all cases.ConclusionThis innovative application of iOCT offers a means to refine the PMS implantation technique by enhancing intraoperative visualization and positioning accuracy. The integration of iOCT has the potential to enhance the surgical techniques of experienced surgeons as well as to improve the training of junior practitioners.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1932-1937"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term efficacy of faricimab switch on retinal exudative signs in patients requiring frequent anti-VEGF injections : A real-life study. 法利昔单抗开关对需要频繁注射抗vegf的患者视网膜渗出性征象的短期疗效：一项现实研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 DOI: 10.1177/11206721251374263

Maïlys Charmasson, Kevin Mairot, Pierre Gascon, Florian Dalmas, Thierry David, Alban Comet

{"title":"Short-term efficacy of faricimab switch on retinal exudative signs in patients requiring frequent anti-VEGF injections : A real-life study.","authors":"Maïlys Charmasson, Kevin Mairot, Pierre Gascon, Florian Dalmas, Thierry David, Alban Comet","doi":"10.1177/11206721251374263","DOIUrl":"https://doi.org/10.1177/11206721251374263","url":null,"abstract":"ObjectiveTo evaluate the efficacy of switching from anti-vascular endothelial growth factor (VEGF) to faricimab in reducing exudative signs in age-related macular degeneration (AMD) patients receiving regular injections (every 8 weeks or less) without restarting a standard induction regimen.MethodsThis retrospective, observational, multicenter study included patients with exudative AMD previously treated with aflibercept 2 mg or ranibizumab every ≤8 weeks and switched to faricimab while maintaining their previous injection interval. The first follow-up visit occured after switching to faricimab, with a single injection, and corresponded to the pre-existing injection interval. Primary outcomes included changes in subretinal (SRF) and intraretinal fluid (IRF).ResultsAmong 39 patients (47 eyes), the proportion of eyes with SRF decreased from 43.1% to 23.5% (p < 0.01) and IRF from 43.8% to 19.6% (p < 0.01). SRF height significantly reduced from 75.3 μm to 60 μm (p = 0.04). Pigment epithelial detachment (PED) height decreased from 223 μm to 164μm (p < 0.01), and central retinal thickness (CRT) declined from 273.7 μm to 268 μm (p < 0.01). Injection intervals extended by an average of 7 days (40 to 47 days, p < 0.01). No significant changes in BCVA (p = 0.14) were observed. No adverse events were reported.ConclusionsSwitching to faricimab without restarting an induction phase effectively reduces SRF and IRF while modestly extending injection intervals in patients requiring frequent anti-VEGF injections. These findings suggest a potential benefit in treatment burden reduction. Further studies are needed to assess long-term visual outcomes and safety.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251374263"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling advanced glycation end products as emerging therapeutic targets in diabetic retinopathy management. 揭示晚期糖基化终产物作为糖尿病视网膜病变管理的新兴治疗靶点。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-03-23 DOI: 10.1177/11206721251328562

Sandeep Saxena, Nibha Mishra, Gemmy Cheung, Srinivas R Sadda

{"title":"Unravelling advanced glycation end products as emerging therapeutic targets in diabetic retinopathy management.","authors":"Sandeep Saxena, Nibha Mishra, Gemmy Cheung, Srinivas R Sadda","doi":"10.1177/11206721251328562","DOIUrl":"10.1177/11206721251328562","url":null,"abstract":"Diabetes mellitus, characterized by chronic hyperglycemia, is a rapidly growing global health concern with an anticipated prevalence of 700 million by 2045. Diabetic retinopathy (DR), a major complication, is the leading cause of vision loss in working-age adults worldwide. Neurovascular units (NVUs), comprising neurons, glial cells, and vessels, maintain retinal homeostasis, and their impairment is considered a primary pathological change in early DR. While glycemic control is conventionally assessed by hemoglobin A1c (HbA1c), studies suggest additional factors influencing DR risk beyond equivalent HbA1c levels. Chronic hyperglycemia triggers neurovascular impairment through advanced glycation end-products (AGEs), inflammation, and oxidative stress. AGEs, accumulating irreversibly, play a crucial role in DR and other diabetic complications. Therapeutic interventions targeting AGEs, both endogenous and exogenous, are gaining traction, offering potential avenues to preserve NVU function. Existing drugs such as pioglitazone, angiotensin II receptor blockers, ACE inhibitors, calcium channel blockers, and statins, along with natural compounds like benfotiamine and cinnamon bark extract, show promise as anti-AGE strategies. This multifaceted approach presents a paradigm shift in early diabetic retinopathy treatment, with ongoing research focusing on refining these strategies for improved management.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1527-1530"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of corneal structural changes by in vivo confocal microscopy in thyroid-associated ophthalmopathy patients. 甲状腺相关性眼病患者角膜结构改变的体内共聚焦显微镜观察。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-27 DOI: 10.1177/11206721251332675

Umit Yasar Guleser, Ayse Yildiz, Havva Sezer, Secil Ozisik, Cem Kesim, Murat Hasanreisoglu, Oguzhan Deyneli, Dilek Yazici, Afsun Sahin

{"title":"Investigation of corneal structural changes by in vivo confocal microscopy in thyroid-associated ophthalmopathy patients.","authors":"Umit Yasar Guleser, Ayse Yildiz, Havva Sezer, Secil Ozisik, Cem Kesim, Murat Hasanreisoglu, Oguzhan Deyneli, Dilek Yazici, Afsun Sahin","doi":"10.1177/11206721251332675","DOIUrl":"10.1177/11206721251332675","url":null,"abstract":"PurposeTo investigate the corneal subbasal nerve plexus (SBP) and dendritic cell (DC) density changes in patients with thyroid-related ophthalmopathy (TAO) using in vivo confocal microscopy (IVCM).MethodsThirty-three patients with inactive TAO and 36 healthy controls were included. All participants underwent comprehensive ophthalmologic examinations and IVCM. Corneal nerve fiber length (CNFL), density (CNFD), branch density (CNBD), total branch density (CTBD), fiber area (CNFA), fiber width (CNFW), fractal dimension (CNFrD) and DC density were analyzed using semi-automated and automated methods. Clinical features, ocular surface parameters, and correlations with IVCM findings were assessed.ResultsTAO patients exhibited significant reductions in CNFL, CNFD, CNBD, CTBD, CNFA, CNFrD and increased DC density compared to controls (p < 0.05). CNBD and CNFrD demonstrated the highest diagnostic sensitivity and specificity. Corneal nerve damage and increased DC density correlated with worsened ocular surface parameters, including reduced non-invasive average tear break-up time, The Schirmer test values and increased ocular surface disease index score. No significant association was found between IVCM parameters and systemic markers such as Clinical Activity Score, thyroid-stimulating hormone (TSH) and disease duration.ConclusionTAO patients show corneal nerve degeneration and inflammation detectable by IVCM. These findings highlight immune-mediated mechanisms underlying corneal SBP damage and their association with ocular surface dysfunction, underscoring the potential of IVCM in clinical assessments and targeted therapeutic strategies.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1593-1603"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ocular surface squamous neoplasia: Growth, diagnosis, and treatment. 眼表鳞状瘤变：生长、诊断和治疗。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-24 DOI: 10.1177/11206721251337166

Xi Lan, Zhiwen Xie, Xie Fang, Shunrong Luo, Xianwen Xiao, Yuan Lin, Zhirong Lin, Huping Wu

{"title":"Ocular surface squamous neoplasia: Growth, diagnosis, and treatment.","authors":"Xi Lan, Zhiwen Xie, Xie Fang, Shunrong Luo, Xianwen Xiao, Yuan Lin, Zhirong Lin, Huping Wu","doi":"10.1177/11206721251337166","DOIUrl":"10.1177/11206721251337166","url":null,"abstract":"BackgroundOcular surface squamous neoplasia (OSSN) is the most common malignancy of the ocular surface, often presenting as a non-pigmented lesion with atypical squamous epithelialization. It is usually asymptomatic and can be confused with benign conditions such as pterygium or conjunctival cysts. If untreated, OSSN may progress to invasive squamous cell carcinoma, causing vision loss or metastasis. The gold standard for diagnosing OSSN is histopathological examination after tumor resection. However, there are still unresolved issues in the clinical management of treatment.Main textIn this review, we have discussed the clinical characteristics, diagnostic techniques, and treatment options for OSSN. OSSN occurs due to changes in the living environment and ocular surface state. It starts as a benign squamous epithelial tumor, which can progress to atypical intraepithelial neoplasia and eventually turn into invasive squamous cell carcinoma. The postoperative pathological histology also shows a corresponding degree of differentiation. Various diagnostic techniques, such as diagnostic imaging, cell biology, and molecular biology, are emerging as valuable tools for distinguishing OSSN. Although surgical resection is the primary treatment for OSSN, drug therapy can also be applied for better management of OSSN treatment.ConclusionAccurately diagnosing OSSN requires advanced examination techniques before and after operation. This is crucial for healthcare professionals to evaluate and treat the condition effectively. Based on our clinical expertise, administering drug treatment before or after surgical resection may serve as a comprehensive and effective management approach for OSSN. This research holds immense potential for the future of personalized and precise medical care.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1921-1931"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nontargeted metabolomics analysis in allergic conjunctivitis. 过敏性结膜炎的非靶向代谢组学分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-02 DOI: 10.1177/11206721251338495

Nagihan Demirtas, Onur Senol, Emine Cinici, Büşra Sahin Mazlumoglu, Mehmet Atakay, Bekir Salih, Saziye Sezin Palabiyik-Yucelik

{"title":"Nontargeted metabolomics analysis in allergic conjunctivitis.","authors":"Nagihan Demirtas, Onur Senol, Emine Cinici, Büşra Sahin Mazlumoglu, Mehmet Atakay, Bekir Salih, Saziye Sezin Palabiyik-Yucelik","doi":"10.1177/11206721251338495","DOIUrl":"10.1177/11206721251338495","url":null,"abstract":"PurposeAllergic conjunctivitis is a disease with a high prevalence in the world. In this study, untargeted metabolomics analyzes were performed to investigate the metabolic profile of the disease in serum samples of allergic conjunctivitis patients.MethodsSerum samples were obtained from 20 allergic conjunctivitis patients and 20 healthy subjects. Untargeted metabolomics analyzes were performed by LC/Q-TOF/MS (liquid chromatography quadrupole time-of-flight mass spectrometry) method. Data collection, classification and identification were performed with the METLIN database and XCMS.ResultsA total of 152 different metabolites were identified and labeled. All annotated metabolites exhibited a 1.5-fold change (increase or decrease) and had a p-value of less than or equal to 0.05 when comparing groups. All statistical data indicated that the model was statistically significant and the p-value is less than or equal to 0.05. All annotated metabolites were evaluated and pathway analysis were performed with significantly altered metabolites.ConclusionIn this study, significant differences in histamine, fatty acid, sphingolipid, purine, vitamin and melatonin metabolism were observed in allergic conjunctivitis patients. It has been determined that disruption of the cell barrier due to changes in fat metabolism, activation of inflammation pathways and irregularity in sphingolipid metabolism play an important role in the underlying mechanisms of allergic conjunctivitis.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1569-1584"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Play, pressure, and pachychoroid: A case series on e-sports players. 游戏，压力和厚脉络膜：电子竞技选手的案例系列。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-06 DOI: 10.1177/11206721251340092

Mehmet Cem Sabaner, Irem Gunes, Fatih Gurdal, Elon H C van Dijk, Prithvi Ramtohul, Yousif Subhi

{"title":"Play, pressure, and pachychoroid: A case series on e-sports players.","authors":"Mehmet Cem Sabaner, Irem Gunes, Fatih Gurdal, Elon H C van Dijk, Prithvi Ramtohul, Yousif Subhi","doi":"10.1177/11206721251340092","DOIUrl":"10.1177/11206721251340092","url":null,"abstract":"PurposeThe pachychoroid disease spectrum is characterized by choroidal thickening, vascular hyperpermeability, and structural alterations in the choroidal circulation. This can lead to central serous chorioretinopathy (CSC), which is clinically seen as retinal pigment epithelium detachments and subretinal fluid accumulation. Despite the fact that corticosteroid exposure is a main risk factor for CSC, its pathogenesis is unknown. This paper describes a case series in which individuals engaged in competitive video gaming presented with pachychoroid disease, and sheds light on the impact of prolonged screen exposure and e-sports-related stress on pachychoroid disease.Case presentationWe report 8 male e-sports players diagnosed with pachychoroid disease, including 6 with CSC and 2 with uncomplicated pachychoroid. All reported average daily screen exposure of 5-10 h and heightened stress during tournaments. Some cases resolved with lifestyle changes, while others required medical intervention. Reduction in video gaming and stress was correlated with symptomatic improvement.ConclusionsHigh-intensity e-sports may contribute to pachychoroid disease through prolonged screen exposure and sustained stress. Live streaming and competitive pressure may amplify these effects. Stress management and regulated screen time could mitigate risks. This case series highlights a possible association between prolonged gaming stress and pachychoroid disease. Awareness and the implementation of preventive measures are essential for maintaining ocular health in e-sports players. Further research with larger cohorts is needed.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP23-NP31"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of outcomes of continuous-wave and micropulse trans-scleral cyclophotocoagulation: A retrospective cohort study. 连续波和微脉冲经巩膜光凝治疗效果的比较：一项回顾性队列研究。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-04-15 DOI: 10.1177/11206721251332674

Shahin Hallaj, Bahram Pashaee, Christian J Nieves, Sagar J Shah, Sopuruchukwu Ezeonu, Tina Xia, Ananya Garg, Young Sheng, Elizabeth A Dale, Courtland Schmidt, Aakriti G Shukla, Michael J Pro, Natasha N Kolomeyer, Daniel Lee, Marlene R Moster, Jonathan S Myers, Reza Razeghinejad

{"title":"Comparison of outcomes of continuous-wave and micropulse trans-scleral cyclophotocoagulation: A retrospective cohort study.","authors":"Shahin Hallaj, Bahram Pashaee, Christian J Nieves, Sagar J Shah, Sopuruchukwu Ezeonu, Tina Xia, Ananya Garg, Young Sheng, Elizabeth A Dale, Courtland Schmidt, Aakriti G Shukla, Michael J Pro, Natasha N Kolomeyer, Daniel Lee, Marlene R Moster, Jonathan S Myers, Reza Razeghinejad","doi":"10.1177/11206721251332674","DOIUrl":"10.1177/11206721251332674","url":null,"abstract":"PurposeThis study aimed to compare and provide data on the outcomes of continuous wave (CWCPC) and micropulse transscleral cyclophotocoagulation (MPCPC).MethodsThis was a retrospective cohort study of 130 glaucomatous eyes that underwent CWCPC with a minimum 6-month follow-up matched 1:1 with 130 eyes that underwent MPCPC. The main outcome measure was CPC failure, defined as intraocular pressure (IOP) reduction of <20%, therapy advancement, or progression to no light perception. The secondary outcome measure was safety profile and complications.ResultsThe mean age of patients in the CWCPC and MPCPC groups was 64.4 ± 16.4 and 64.0 ± 17.2 years, respectively. Most patients were male (56.5%), and 48.5% were White. Primary open-angle glaucoma was the most common glaucoma diagnosis (40.4%), 58.5% of the patients had severe glaucoma. Mean preoperative IOP and number of medications were 29.8 ± 10.6 mmHg and 3.7 ± 1.3, respectively. The failure rates at 6 months (46.9% vs. 18.5%) and 1 year (61.5% vs. 40.8%) were higher in MPCPC group (p = 0.001). Mean IOP reduction was slightly greater in the CWCPC group (15.1 ± 13.9 mmHg vs. 14.2 ± 10.4, p = 0.5). Lower laser energy (HR:0.995) and MPCPC (HR:1.698) were associated with higher risk of failure (p = 0.002). The complication rate was higher in the CWCPC group (13.8% vs. 4.6%, p < 0.001); vision loss occurred more in the CWCPC group (4.6% vs. 2.3%), and the only phthisis bulbi occurred in one of the eyes of CWCPC group.ConclusionCWCPC was more effective in lowering the IOP despite delivering less total energy than MPCPC but had a higher rate of complications.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1647-1653"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12276928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling restrictive strabismus in a Complex presentation With residual esotropia - A case report. 限制性斜视的复杂表现及残余内斜视1例报告。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-04 DOI: 10.1177/11206721251338702

Stevie Kresentia, Luki Indriaswati

{"title":"Unveiling restrictive strabismus in a Complex presentation With residual esotropia - A case report.","authors":"Stevie Kresentia, Luki Indriaswati","doi":"10.1177/11206721251338702","DOIUrl":"10.1177/11206721251338702","url":null,"abstract":"IntroductionThe onset of ocular misalignment can be either congenital or acquired, with each type of strabismus exhibiting distinct clinical features that help differentiate it from others. In this case, we aim to discuss conditions that mimic restrictive strabismus and their management.Case descriptionA 14-year-old girl presented with a complaint of her left eye turning inward, which had been present since infancy. Clinical examination revealed bilateral medial rectus overaction. She had underwent surgery for a meningocele five years ago. The left eye examination: visual acuity was 2/60, anterior segment was normal, esotropia, and a -3 limitation of abduction and the force duction test was positive. She was diagnosed with congenital esotropia, with restrictive esotropia considered as a differential diagnosis. She underwent surgery to released cicatricial tissue and recession rectus medial. After the surgery, the left eye esotropia still remained. Neuroimaging was conducted to identify the underlying cause. The result described left fronto-orbital meningoencephalocele caused fibrosis around the left medial rectus tendon. A second surgery involving lateral rectus resection was performed, and orthophoria was achieved at both eyes.ConclusionsThis case report illustrates that any abnormalities involving the orbital structures can be a potential cause of restrictive strabismus, especially when certain clinical features are incongruent with the initial diagnosis. Meticulous history taking and thorough clinical examination are essential to achieve an accurate diagnosis and management.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP64-NP68"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Cilioretinal artery occlusion: Current scenario". “纤毛视网膜动脉闭塞：当前情况”。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-09-01 Epub Date: 2025-05-27 DOI: 10.1177/11206721251345616

Ginu Pm, Aiswarya R, Sanjay Dhar, Neeraj Sharma

{"title":"\"Cilioretinal artery occlusion: Current scenario\".","authors":"Ginu Pm, Aiswarya R, Sanjay Dhar, Neeraj Sharma","doi":"10.1177/11206721251345616","DOIUrl":"10.1177/11206721251345616","url":null,"abstract":"IntroductionAbout 5% of retinal artery occlusions are cilioretinal artery occlusions (CLRAO). It was found to be mostly unilateral (70.30% to 93.65%) and temporal in location (80.77% to 100%).EtiopathogenesisRisk factors for CLRAO include emboli from various atheromas, vasculitis, collagen vascular disorders, hypertensive vascular changes, hemoglobinopathies, hypercholesterolemia, hypercoagulable conditions, arrhythmias, migraine etc.Clinical presentationCilioretinal artery occlusion may present in three different scenarios: i) Isolated ii) with central retinal vein occlusion (CRVO) iii) in combination with Ischemic optic neuropathy.Imaging featuresFFA shows slow filling of cilioretinal artery. SD OCT may reveal hyperreflectivity of inner retinal layers. OCTA will show non perfusion of CLRA along with compromised perfusion of superficial and deep retinal capillary plexus and hyper reflective inner retinal layers. Perimetry shows paracentral scotoma which may be persistent in many cases. Association of paracentral acute middle maculopathy (PAMM) with isolated CLRAO causing paracentral scotomas, has been reported. Type 1 PAMM lesions affect layers above outer plexiform layer (OPL) and Type 2 PAMM involve layers below OPL.ManagementTime period for active intervention is between 4.5 to 12 h. Meta-analysis reports suggest administration of thrombolytic agents before 4.5 h for better outcome. Hyperbaric oxygen (HBO) therapy is another modality. Reduction of intraocular pressure need to be achieved. Methyl prednisolone is advisable in CLRAO associated with Giant cell arteritis and other vasculitis. American Heart Association suggests administration of intravenous or intraarterial tissue Plasminogen Activator (tPA) as a viable option.ConclusionCLRAO and its management still has the potential for further research and trials.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1896-1900"},"PeriodicalIF":1.4,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0