European Journal of Ophthalmology最新文献_第6页

The variation in axial length in office hours causes a diopter change in the intraocular lens power calculation. 办公时间眼轴长度的变化导致人工晶状体度数计算屈光度的变化。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2024-12-04 DOI: 10.1177/11206721241304154

Gabor Nemeth, Agnes Revak, Peter Vamosi, Agnes Elekes, Laszlo Modis, Zoltan Sohajda

{"title":"The variation in axial length in office hours causes a diopter change in the intraocular lens power calculation.","authors":"Gabor Nemeth, Agnes Revak, Peter Vamosi, Agnes Elekes, Laszlo Modis, Zoltan Sohajda","doi":"10.1177/11206721241304154","DOIUrl":"10.1177/11206721241304154","url":null,"abstract":"PurposeTo investigate whether diurnal changes in biometric parameters at different times of the day are visible and to analyze whether the variations could have clinical significance in the process of intraocular lens (IOL) power calculation.MethodsPhakic eyes measured by IOLMaster 700 above the age of 16 were included, with the exclusion of previous surgery. Measurements were taken between 7:00 and 15:00 and data were treated in hourly groups within this range. Data such as age, sex and biometric parameters (axial length (AL), anterior chamber depth, central corneal thickness, white-to-white distance, keratometry readings, lens thickness) were used besides the hour:minute time of the examination.ResultsBiometric data from 32,596 eyes were used (38.89% males). There were no statistically significant differences in age and biometric parameters between the office-hour groups (p > 0.05), excluding the AL. The AL at the end of the day was 0.198 mm longer for male and 0.197 mm longer for female compared to the beginning of the office day. Accordingly, the results of IOL power calculation varied between 21.0 and 20.0 D for male, and 21.5 D and 20.5 D for the female population.ConclusionThe results suggest that the assessment of AL may be affected by the intraday time of the biometry. This variation is clinically significant and may have implications for the evaluation of AL.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1162-1168"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Idiopathic epiretinal membrane surgery with internal limiting membrane peeling: An optical coherence tomography angiography analysis of macular capillary plexus changes. 特发性视网膜前膜手术合并内限制膜剥离：黄斑毛细血管丛改变的光学相干断层血管造影分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2024-12-19 DOI: 10.1177/11206721241304139

Luigi Caretti, Giulia Pillon, Giacomo Verzola, Edoardo Angelini, Cristina Monterosso, Vincenza Bonfiglio, Antonio Longo, Martina Formisano

{"title":"Idiopathic epiretinal membrane surgery with internal limiting membrane peeling: An optical coherence tomography angiography analysis of macular capillary plexus changes.","authors":"Luigi Caretti, Giulia Pillon, Giacomo Verzola, Edoardo Angelini, Cristina Monterosso, Vincenza Bonfiglio, Antonio Longo, Martina Formisano","doi":"10.1177/11206721241304139","DOIUrl":"10.1177/11206721241304139","url":null,"abstract":"PurposeThis study aims to assess retinal vascular changes following internal limiting membrane (ILM) peeling for idiopathic epiretinal membrane (ERM) treatment using optical coherence tomography angiography (OCT-A).DesignA retrospective study was conducted.MethodsA cohort of thirty-nine patients was enlisted for this study. Each participant underwent comprehensive ophthalmological evaluation and OCT-A imaging at baseline, as well as at 1-month and 6-month intervals post-pars plana vitrectomy with ERM and ILM peeling.ResultsPost-surgery, remarkable improvements were observed in best-corrected visual acuity (BCVA) (from 0.335 ± 0.173 to 0.096 ± 0.126 at 6 months), coupled with a notable reduction in central retinal thickness (CRT) (from 460 ± 87 µm to 395 ± 53 µm at 6 months). Additionally, there was a noticeable expansion in the foveal avascular zone (FAZ) perimeter (from 0.099 ± 0.060 mm² to 0.125 ± 0.056 mm² at 6 months). However, there was a decline in vessel density (VD) in the superficial capillary plexus (SCP) (from 46.7 ± 4.4 to 43.8 ± 3.5% at 6 months), contrasted by an elevation in the deep capillary plexus (DCP) (from 45.2 ± 5.5% to 43.6 ± 5.3% at 6 months. Noteworthy correlations were detected between CRT and BCVA, as well as CRT and vascular parameters.ConclusionERM instigates a milieu of changes including SCP crowding and elevation, potentially leading to a falsely augmented density at OCT-A in affected patients. Subsequent surgery results in a release of ERM-induced forces, elucidating the observed decrease in SCP density. Conversely, the DCP appears to be less distorted by the ERM, facilitating gradual vessel reopening after its removal. OCTA provides valuable insights into optimal surgical timing.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1394-1401"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142853233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Brazilian case of extensive macular atrophy with pseudodrusen and non-exudative quiescent macular neovascularization. 巴西一例广泛黄斑萎缩伴假性囊肿和非渗出性静止性黄斑新生血管。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-04-01 DOI: 10.1177/11206721251333274

Dotnara de Faria Corrêa Roncato, Beatrice Tombolini, Luize de Faria Corrêa Roncato, Ricardo Japiassú, Nolvar Spessato, Riccardo Sacconi, Giuseppe Querques, Francesco Bandello

{"title":"A Brazilian case of extensive macular atrophy with pseudodrusen and non-exudative quiescent macular neovascularization.","authors":"Dotnara de Faria Corrêa Roncato, Beatrice Tombolini, Luize de Faria Corrêa Roncato, Ricardo Japiassú, Nolvar Spessato, Riccardo Sacconi, Giuseppe Querques, Francesco Bandello","doi":"10.1177/11206721251333274","DOIUrl":"10.1177/11206721251333274","url":null,"abstract":"PurposeTo report a case of extensive macular atrophy with pseudodrusen (EMAP) complicated by a non-exudative quiescent type 1 macular neovascularization (MNV).Case descriptionA 65-years-old male patient complained of bilateral progressive visual loss and nyctalopia over the last ten years. Fundus examination showed in both eyes central foveal sparing geographic atrophy partially extending outside vascular arcades, reticular pseudodrusen (RPD), and mid-periphery pavingstone degenerations. On optical coherence tomography (OCT), RPD, basal laminar deposits, retinal pigmented epithelium and outer retinal atrophy were detected bilaterally. In left eye (LE), a perifoveal mid-reflective pigment epithelium detachment (PED) with no neovascular activity signs (e.g., macular hemorrhage, intraretinal/subretinal fluid, subretinal hyperreflective material) was found. Fluorescein angiography revealed in LE a hyperfluorescence coincident with PED without leakage on late phase. OCT-angiography displayed a pathological neovascular network consistent with a non-exudative type 1 neovascularization. No treatment was performed and the patient was closely followed. On last consultation six months later, MNV was stable with no identifiable activation signs. Based on these findings, a diagnosis of EMAP complicated by non-exudative quiescent type 1 neovascularization was hypothesized.DiscussionSimilarly to age-related macular degeneration, EMAP could be associated to non-exudative neovascularization. Choriocapillaris loss could be the trigger for the development of vascular sprouts, representing the precursor of non-exudative type 1 MNV.ConclusionThis case-report supported the importance of at least six-months follow-up for NE-MNV in EMAP. Further studies are needed to confirm our result and to consolidate therapeutic management of MNV in this rare macular disorder.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP44-NP48"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Murphy's Law in cataract surgeries: A retrospective analysis. 白内障手术中的墨菲定律：回顾性分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-01-06 DOI: 10.1177/11206721241310470

Jaskaran Singh Bhangu, Christopher Stewart, Tamsin Bakhiet, Derek Kwun-Hong Ho, Tina Parmar, Suzanne Tolley, Gwyn Samuel Williams

{"title":"Murphy's Law in cataract surgeries: A retrospective analysis.","authors":"Jaskaran Singh Bhangu, Christopher Stewart, Tamsin Bakhiet, Derek Kwun-Hong Ho, Tina Parmar, Suzanne Tolley, Gwyn Samuel Williams","doi":"10.1177/11206721241310470","DOIUrl":"10.1177/11206721241310470","url":null,"abstract":"ObjectiveAround 400,000 cataract operations are performed annually in the UK, with a complication rate of 1.95% and the associated financial costs at over £13 million. Cataract operations are occasionally cancelled when patients cannot attend. To fully utilize theatre time, agreeable patients may be directly sent for surgery from assessment clinics. This study investigates the validity of \"Murphy's Law\" in ophthalmology, namely, whether there is an increase in complication rates amongst these 'add-on' cases.Design & ParticipantsRetrospective study to compare data of add-on phacoemulsification operations against the departmental baseline.MethodsChi-square test was used to determine whether the complication rates differed significantly. 1-sided p-value of <0.05 was considered to be significant.Results227 'add-on' cases were identified, of which 3 complications occurred. Departmental baseline of 4289 operations resulted in 44 complications. These represented complication rates of 1.32% and 1.03%, respectively. The level of surgical difficulty between the two groups were comparable. Statistical comparison of these complication rates demonstrated a p-value of 0.67, indicating that Murphy's Law is not significant.ConclusionsThis is the first study of its kind to examine the rates of adverse outcomes in unscheduled 'add-on' cataract surgeries, a commonly deployed method to maximize eye theatre time usage. Our data suggested no significant difference in complication rates between the add-on operations and local baseline. Thus, we demonstrated that the practice of same day proceeding from pre-operative assessment clinic to the operating table is a safe option to optimize theatre time use, should a surgery cancellation arise.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":"35 4","pages":"1203-1206"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

"Intrableb pigmentation following XEN implantation: A case series". XEN植入术后皮下色素沉着：一个病例系列。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-01-08 DOI: 10.1177/11206721241310267

Filippo Tatti, Giuseppe Demarinis, Stefano Dore, Matteo Sacchi, Maurizio Fossarello, Enrico Peiretti, Giuseppe Giannaccare

{"title":"\"Intrableb pigmentation following XEN implantation: A case series\".","authors":"Filippo Tatti, Giuseppe Demarinis, Stefano Dore, Matteo Sacchi, Maurizio Fossarello, Enrico Peiretti, Giuseppe Giannaccare","doi":"10.1177/11206721241310267","DOIUrl":"10.1177/11206721241310267","url":null,"abstract":"PurposeTo evaluate the incidence and to describe the characteristics of the intrableb pigmentation (IBP) following XEN63 implantation.MethodsRetrospective case series of three eyes presenting a pigment dispersion in the filtering bleb after a XEN63 implantation for uncontrolled IOP. Demographic, clinical and imaging data were obtained from medical records.ResultsThree out of 40 patients who underwent XEN implantation (average age 70.67 years) showed an IBP during the 12 months postoperative period. The mean time of IBP onset was 50 days (range, 15-90). The slit lamp examination showed two IBP patterns: a \"diffuse\" pattern (2 patients) with multiple spots of pigmentation inside the bleb; a \"punctiform\" pattern (1 patient), with a single spot at the distal end of the device. The AS-OCT imaging confirmed the presence of IBP appearing as a hyperreflective spot/s in the context of the filtering bleb. The patient with the punctiform IBP experienced a distal XEN ostium obstruction with a decrease in bleb function. In one case the diffuse IBP occurred after a successful needling procedure. All the patients' IOP reported at the end of the follow-up was below 21 mmHg.ConclusionThe development of IBP might occur after XEN implantation in various times and with different patterns. The IBP pattern can provide meaningful clues on the bleb filtering function. A proper follow-up based on slit lamp biomicroscopy, IOP measurement, and AS-OCT imaging is recommended to manage potential complications related to IBP.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1288-1294"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frosted branch angiitis post COVID vaccine: A presumptive association with Behçet's disease. 冠状病毒疫苗后的霜状支血管炎：与behaperet病的推定关联

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-02-19 DOI: 10.1177/11206721251321537

Victor Alegre-Ituarte, Bahram Bodaghi, Sara Touhami

{"title":"Frosted branch angiitis post COVID vaccine: A presumptive association with Behçet's disease.","authors":"Victor Alegre-Ituarte, Bahram Bodaghi, Sara Touhami","doi":"10.1177/11206721251321537","DOIUrl":"10.1177/11206721251321537","url":null,"abstract":"PurposeTo report a case highlighting the uncommon presentation of Frosted Branch Angiitis (FBA) in Behçet's Disease (BD), notably in a patient who received a COVID vaccine one month prior to the onset of symptoms. We explore the possible role of vaccination in unmasking BD.MethodsA comprehensive evaluation of a 45-year-old patient with FBA post-COVID vaccination was undertaken.ResultsThe patient exhibited characteristic features of FBA, with classic perivascular sheathing, optic disc edema, and retinal ischemia, which manifested one month after receiving the Pfizer/BioNTech COVID vaccine. Despite a history of recurrent oral aphthosis, systemic workup for autoimmune conditions was unremarkable. Diagnosis of presumptive Behçet's Disease was made based on clinical criteria. Treatment with intravenous methylprednisolone and infliximabn (5 mg/kg) led to complete resolution of ocular symptoms and retinal signs.ConclusionFBA is an uncommon presentation of BD. This case also serves as a stark reminder of the potential consequences of vaccination on immune-mediated diseases. However, the correlation between FBA onset, COVID vaccination, and Behçet's Disease diagnosis necessitates cautious interpretation. Successful use of methylprednisolone and infliximab in achieving resolution of visual symptoms highlights potential therapeutic considerations in similar cases.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"NP54-NP57"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term effect of repeated low-level red light therapy on myopia control: A systematic review and meta-analysis. 反复低强度红光治疗对近视控制的长期影响：系统回顾和荟萃分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-07-01 Epub Date: 2025-02-21 DOI: 10.1177/11206721251314541

Saif Ullah, Muhammad Farooq Umer, Suriyakala Perumal Chandran

{"title":"Long-term effect of repeated low-level red light therapy on myopia control: A systematic review and meta-analysis.","authors":"Saif Ullah, Muhammad Farooq Umer, Suriyakala Perumal Chandran","doi":"10.1177/11206721251314541","DOIUrl":"10.1177/11206721251314541","url":null,"abstract":"IntroductionMyopia is a refractive error where distant objects are not clearly seen and appear blurred. Goal of this study was to evaluate long-term effectiveness of Repeated Low-Level Red Light (RLRL) therapy for children with myopia, which primarily focused on Axial length (AL) and Spherical Equivalent Refraction (SER) as primary endpoints.MethodsThe research compared outcomes between RLRL treatment with Single Vision Spectacles (SVS) for childhood myopia management. We performed a systematic literature search in the PubMed, Embase and Cochrane databases using \"Myopia\" and \" Repeated Low-Level Red Light \". Mean differences (MD) were estimated and the effects of therapies measured. Publication bias and heterogeneity analysis were carried out by Inverted Precision Effect Test-Precision Effect Estimate Standard Error (PET-PEESE) (and subsequent Search Sequential Analysis) and Tau test. Bayesian meta-analysis was performed using Jaffrey Amazing Statistical Package (JASP).ResultsThis meta-analysis comprised 1,714 participants: 824 in RLRL and 890 in SVS group. Pooled effect size for AL reduction was 0.953 ± 0.294, (95% credible interval (CI) 0.775 to 0.980). Pooled effect size for SER reduction was 1.521 ± 0.662 (95% CI 0.102 to 2.736). PET-PEESE analysis revealed no significant publication bias (p-value 0.407). Random effects models were employed for presence of significant heterogeneity (3.9 and 5.7 for AL; 5.7 for SER), alongside degree of variation (0.828 & 1.665) for Tau (τ), which estimates the between-study variance.ConclusionLong-term observations indicate that RLRL treatment significantly influences myopia management, leading to considerable reductions in both AL and SER. Additional research is essential to investigate potential long-term rebound effects.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"1432-1444"},"PeriodicalIF":1.4,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accuracy of ultra-wide field fundus photography for identifying diabetic retinal neovascularization compared to fluorescein angiography. 超广角眼底摄影鉴别糖尿病视网膜新生血管的准确性与荧光素血管造影的比较。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-30 DOI: 10.1177/11206721251349042

Rabab A Mahmoud, Weam M Ebeid, Rania G Estawro

{"title":"Accuracy of ultra-wide field fundus photography for identifying diabetic retinal neovascularization compared to fluorescein angiography.","authors":"Rabab A Mahmoud, Weam M Ebeid, Rania G Estawro","doi":"10.1177/11206721251349042","DOIUrl":"https://doi.org/10.1177/11206721251349042","url":null,"abstract":"PurposeTo evaluate the efficacy of ultrawide field fundus photography (UWFFP) in detecting diabetic neovascularization, with a comparative analysis against ultrawide field fluorescein angiography (UWFFA).MethodsA retrospective cross-sectional study was conducted using images from 100 eyes of 62 treatment-naïve patients with proliferative diabetic retinopathy (PDR), all of whom underwent both UWFFP and UWFFA on the same day. Two masked graders independently evaluated the UWFFP images to identify neovascular lesions, which were categorized into three predefined anatomical zones: neovascularization of the disc (NVD), neovascularization of the mid-periphery (NV-MP; within 10 mm of the fovea), and neovascularization of the far periphery (NV-FP; beyond 10 mm from the fovea). The findings were subsequently compared with those obtained from UWFFA. Sensitivity and specificity analyses were conducted to evaluate differences in detection rates between the two methods.ResultsUWFFP detected NVD and NV-MP effectively, with the highest specificity for NVD (98.2%) and a high sensitivity for NV-MP (90.2%). Strong agreement with UWFFA was observed for NVD (κ = 0.83) and moderate agreement for NV-MP (κ = 0.65). However, UWFFP had lower sensitivity for NV-FP (56.5%) and only moderate agreement (κ = 0.52). McNemar's test showed UWFFA had significantly higher detection rates for NV-FP (46% vs. 29%, p < 0.001).ConclusionUWFFP is a valuable tool for identifying neovascularization associated with diabetic retinopathy in the optic disc and mid-peripheral retina. However, UWFFA remains the superior modality for reliable assessment, particularly in detecting peripheral neovascularization.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251349042"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypermucoviscous Klebsiella corneal abscess: Infection from inside out. 高粘性克雷伯氏菌角膜脓肿：由内而外感染。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-30 DOI: 10.1177/11206721251353631

Ae Ra Kee, Panos G Christakis, Georges Nassrallah, David S Rootman, Sumana Naidu, Clara C Chan

{"title":"Hypermucoviscous Klebsiella corneal abscess: Infection from inside out.","authors":"Ae Ra Kee, Panos G Christakis, Georges Nassrallah, David S Rootman, Sumana Naidu, Clara C Chan","doi":"10.1177/11206721251353631","DOIUrl":"https://doi.org/10.1177/11206721251353631","url":null,"abstract":"BackgroundCorneal ulcers are typically caused by external (\"exogenous\") factors such as trauma, contact lens use, or preexisting ocular surface diseases. Internal systemic (\"endogenous\") sources have not been reported as direct causes of corneal ulcers. Here, we report, to our knowledge, the first documented case of a corneoscleral abscess that resulted from an underlying bacteremia.MethodThis is a single case report.ResultA previously healthy 35-year-old male presented to the Emergency Department with left eye redness, pain, and blurred vision. Initial examination showed reduced visual acuity (20/150), elevated intraocular pressure (44mmHg), diffuse microcystic corneal edema with mutton-fat keratic precipitates, and anterior chamber cells. No corneal infiltrate, epithelial defect, hypopyon, or vitritis was noted. Within days, his condition rapidly progressed to a corneoscleral abscess with auto-evisceration. Blood and corneal cultures identified hypermucoviscous Klebsiella pneumoniae. Further workup revealed an underlying prostatic abscess with secondary iliac vein thrombus, leading to seeding of other sites, including the lungs and the eye. Despite intensive antibiotic therapy, the ocular condition worsened, requiring urgent left eye evisceration.ConclusionThis case highlights the rapid progression of hypermucoviscous Klebsiella pneumoniae infection, which first presented with endophthalmitis, followed by corneoscleral perforation.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251353631"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative efficacy and safety of anti-VEGF agents with and without Laser therapy for diabetic macular edema: A network meta-analysis. 激光治疗与不治疗糖尿病黄斑水肿的抗vegf药物的疗效和安全性比较：一项网络荟萃分析。

IF 1.4 4区医学

European Journal of Ophthalmology Pub Date : 2025-06-30 DOI: 10.1177/11206721251350017

Lin Chen, Mengting Chen, Wenrui Huang

{"title":"Comparative efficacy and safety of anti-VEGF agents with and without Laser therapy for diabetic macular edema: A network meta-analysis.","authors":"Lin Chen, Mengting Chen, Wenrui Huang","doi":"10.1177/11206721251350017","DOIUrl":"https://doi.org/10.1177/11206721251350017","url":null,"abstract":"ObjectiveTo compare the efficacy and safety of Conbercept, Ranibizumab, and Aflibercept, alone or combined with laser, for the treatment of diabetic macular edema (DME).MethodsWe searched PubMed, Cochrane Library, Embase, Web of Science, CNKI, WanFang, and SinoMed until October 2024 for studies on Conbercept, Ranibizumab, and Aflibercept in DME treatment. Bayesian network meta-analysis was conducted in RStudio. Study quality was assessed with the Cochrane ROB.2 and the Confidence in Network Meta-Analysis framework. This study was registered with PROSPERO (CRD42024608409).ResultsA total of 64 randomized controlled trials, including 7,185 patients, were analyzed in this study. Results indicated that Ranibizumab + laser yielded the most significant improvement in central retinal thickness (CRT) at 3 months (MD -80.98, 95% CI -106.53, -55.64; SUCRA 81.92%), 6 months (-90.19, [-126.05, -54.77]; 81.62%), and 12 months (-134.99, [-194.2, -75.98; 87.56%). Conbercept + laser (3 months: -52.47, [-80.7, -24.14]; 6 months: -52.98, [-94.72, -11.02]) and Ranibizumab monotherapy (3 months: -64.45,[-101.28, -26.77]) also showed statistically significant CRT reductions compared to laser alone, though to a lesser degree than Ranibizumab + laser. For Best-Corrected Visual Acuity (BCVA), both Ranibizumab and Ranibizumab + laser achieved statistically significant gains at 6 and 12 months compared to laser alone, with Ranibizumab + laser consistently ranking highest in efficacy. Safety analysis revealed no significant differences in total adverse event rates across treatments.ConclusionRanibizumab + laser therapy demonstrated the greatest improvement in CRT and BCVA at 3, 6, and 12 months, with no significant differences in adverse events compared to other anti-VEGF options.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251350017"},"PeriodicalIF":1.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0