Microvascular changes after proton beam radiotherapy for iris melanoma: An optical coherence tomography angiography study.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Matteo Fallico, Antonio Longo, Teresio Avitabile, Pietro Alosi, Edoardo Dammino, Michele Reibaldi, Paola Marolo, Guglielmo Parisi, Niccolò Castellino, Vincenza Bonfiglio, Rosario Caltabiano, Giuseppe Broggi, Pietro Foti, Corrado Spatola, Marco Ragusa, Cristina Barbagallo, Enrico Borrelli, Andrea Russo
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引用次数: 0

Abstract

PurposeTo evaluate macular and peripapillary microvascular changes after proton beam radiotherapy for iris melanoma using optical coherence tomography angiography (OCT-A).MethodsPatients treated with proton beam radiotherapy for iris melanoma were included in the iris melanoma group. Fellow eyes were used as controls. Vessel density (VD) of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) of the macula, radial peripapillary capillary plexus (RPCP) and foveal avascular zone (FAZ) were evaluated using OCT-A. Central macular thickness (CMT) and nerve fiber layer thickness (RNFL) were also investigated.ResultsA total of 11 patients were included. Vessel density in the whole SCP was comparable between treated eyes and untreated fellow eyes (p = 0.32). Vessel density in the whole DCP was lower in the iris melanoma group compared with untreated fellow eyes: 39% [standard deviation (SD) 1.9] versus 49% (SD 4.1), respectively (p < 0.001). Vessel density of the whole RPCP was lower in the iris melanoma group compared with untreated fellow eyes: 44% (SD 3.5) versus 48% (SD 2.2), respectively (p = 0.02). No differences between treated eyes and untreated fellow eyes were noted when evaluating FAZ, CMT and RNFL thickness.ConclusionIrradiation of the iris may determine vascular damage in the uveal tract, which, consequently, can affect the retinal vascular network. Changes in OCT-A parameters detected in DCP and RPCP may be early signs of microvascular impairment in these patients.

虹膜黑色素瘤质子束放疗后微血管变化:光学相干断层扫描血管造影研究。
目的应用光学相干断层扫描血管造影(OCT-A)评价虹膜黑色素瘤质子束放疗后黄斑及乳头周围微血管的变化。方法采用质子束放疗治疗虹膜黑色素瘤患者为虹膜黑色素瘤组。同伴的眼睛作为对照。ct - a检查黄斑浅毛细血管丛(SCP)和深毛细血管丛(DCP)血管密度(VD)、径向乳头周围毛细血管丛(RPCP)和中央凹无血管区(FAZ)。观察黄斑中央厚度(CMT)和神经纤维层厚度(RNFL)。结果共纳入11例患者。整个SCP的血管密度在治疗眼和未治疗眼之间具有可比性(p = 0.32)。虹膜黑色素瘤组的整个DCP血管密度低于未治疗组:分别为39%[标准差(SD) 1.9]和49% (SD 4.1) (p p = 0.02)。在评估FAZ、CMT和RNFL厚度时,治疗组和未治疗组的眼睛之间没有差异。结论虹膜照射可导致膜束血管损伤,进而影响视网膜血管网。在DCP和RPCP中检测到OCT-A参数的变化可能是这些患者微血管损伤的早期迹象。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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