Rock-Inhibitors eyedrops preventing cataract surgery induced corneal failure in Fuchs corneal dystrophy.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Daniele Gaudenzi, Chiara De Gregorio, Francesco Cutrupi, Francesco Branda, Marco Coassin, Antonio Di Zazzo
{"title":"Rock-Inhibitors eyedrops preventing cataract surgery induced corneal failure in Fuchs corneal dystrophy.","authors":"Daniele Gaudenzi, Chiara De Gregorio, Francesco Cutrupi, Francesco Branda, Marco Coassin, Antonio Di Zazzo","doi":"10.1177/11206721251351154","DOIUrl":null,"url":null,"abstract":"<p><p>PurposeTo evaluate the safety and efficacy of prophylactic Ripasudil in maintaining corneal endothelial function and preventing corneal failure in patients with late-stage Fuchs corneal dystrophy (FCD) undergoing femtolaser-assisted cataract surgery.Major findingsThis prospective, randomized, open-label, controlled interventional study included 41 eyes from 27 patients, 27 eyes treated with Ripasudil and 14 with hyaluronic acid as a control. Treatment was administered from 1 month before cataract surgery through 2 months postoperatively. Primary outcomes included best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell density and morphology, assessed at baseline, 3 months, and 9 months after surgery. Statistical analysis was performed using the unpaired t-test with Welch's correction and the Wilcoxon matched-pairs test, with a significance threshold of <i>p</i> < 0.05. The Ripasudil group showed a significant improvement in BCVA, from0.3 ± 0.3 to 0.2 ± 0.2 LogMAR (<i>p</i> = 0.01), along with stable CCT (556.3 ± 76.4 μm at baseline vs. 563.3 ± 72.2 μm at post-operative month 3, <i>p</i> = 0.39). In contrast, the control group demonstrated no significant improvement in BCVA (<i>p</i> = 0.13) and a significant increase in CCT (from 591.9 ± 59.3 μm to 658.4 ± 74.6 μm, <i>p</i> < 0.01). Endothelial cell density, polymegathism, and pleomorphism remained stable in both groups. At 9 months, Ripasudil-treated eyes continued to show stability in both BCVA and CCT, with no adverse events reported.ConclusionRipasudil demonstrated a protective effect on the corneal endothelium during cataract surgery in late-stage FCD patients, with better visual outcomes and reduced postoperative corneal edema.</p>","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251351154"},"PeriodicalIF":1.4000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/11206721251351154","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

PurposeTo evaluate the safety and efficacy of prophylactic Ripasudil in maintaining corneal endothelial function and preventing corneal failure in patients with late-stage Fuchs corneal dystrophy (FCD) undergoing femtolaser-assisted cataract surgery.Major findingsThis prospective, randomized, open-label, controlled interventional study included 41 eyes from 27 patients, 27 eyes treated with Ripasudil and 14 with hyaluronic acid as a control. Treatment was administered from 1 month before cataract surgery through 2 months postoperatively. Primary outcomes included best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell density and morphology, assessed at baseline, 3 months, and 9 months after surgery. Statistical analysis was performed using the unpaired t-test with Welch's correction and the Wilcoxon matched-pairs test, with a significance threshold of p < 0.05. The Ripasudil group showed a significant improvement in BCVA, from0.3 ± 0.3 to 0.2 ± 0.2 LogMAR (p = 0.01), along with stable CCT (556.3 ± 76.4 μm at baseline vs. 563.3 ± 72.2 μm at post-operative month 3, p = 0.39). In contrast, the control group demonstrated no significant improvement in BCVA (p = 0.13) and a significant increase in CCT (from 591.9 ± 59.3 μm to 658.4 ± 74.6 μm, p < 0.01). Endothelial cell density, polymegathism, and pleomorphism remained stable in both groups. At 9 months, Ripasudil-treated eyes continued to show stability in both BCVA and CCT, with no adverse events reported.ConclusionRipasudil demonstrated a protective effect on the corneal endothelium during cataract surgery in late-stage FCD patients, with better visual outcomes and reduced postoperative corneal edema.

岩石抑制剂滴眼液预防白内障手术引起的角膜衰竭。
目的评价预防性利帕舒地尔在晚期Fuchs角膜营养不良(FCD)患者行飞激光辅助白内障手术中维持角膜内皮功能和预防角膜衰竭的安全性和有效性。主要发现:这项前瞻性、随机、开放标签、对照的干预性研究包括来自27名患者的41只眼睛,其中27只使用利帕舒地尔治疗,14只使用透明质酸作为对照。治疗时间为白内障手术前1个月至术后2个月。主要结果包括最佳矫正视力(BCVA)、角膜中央厚度(CCT)、内皮细胞密度和形态,分别在基线、术后3个月和9个月进行评估。采用Welch校正的非配对t检验和Wilcoxon配对检验进行统计学分析,显著性阈值p p = 0.01),以及稳定的CCT(基线556.3±76.4 μm vs术后第3个月563.3±72.2 μm, p = 0.39)。相比之下,对照组BCVA无显著改善(p = 0.13), CCT显著增加(从591.9±59.3 μm增加到658.4±74.6 μm, p = 0.13)
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信