Changes in various ocular parameters of patients undergoing hemodialysis.

IF 1.4 4区 医学 Q3 OPHTHALMOLOGY
Aseem Kumar, Vijaya Sahu, Somen Misra, Vinay Rathore, Bharat Gurnani, Kirandeep Kaur
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Abstract

PurposeTo assess the alterations in various ocular parameters in patients undergoing hemodialysis.DesignProspective, observational study.MethodsThe study included 113 eyes from 113 patients who underwent hemodialysis due to chronic kidney disease and acute kidney injury between January 2021 and August 2022. All participants underwent complete ophthalmic exam which included best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure (IOP) measurement and dilated examination using slit lamp biomicroscope and indirect ophthalmoscope. Optical coherence tomography (OCT) was done for all patients before they underwent hemodialysis and central subfield thickness (CST), retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thickness were assessed. The ophthalmic exam and OCT scan were repeated within 1-2 h of hemodialysis.ResultsThe mean age (+/- SD) of the study population was 42.14 ± 13.25 years, with 65.5% males. Most participants were aged 41-60 years. BCVA and IOP did not change significantly after hemodialysis (p = 0.74 and p = 0.37, respectively). Retinal parameters showed significant changes, with decreased CST (p < 0.001) and GCC thickness (p = 0.04). There was no significant change in RNFL thickness (p = 0.44). CST positively correlated with dialysate flow rate and negatively with blood flow rate. A weak correlation was found between GCC thickness and ultrafiltration and dialysate flow rate.ConclusionHemodialysis causes alterations in retinal parameters with a decrease in the CST and GCC thickness.

血液透析患者各项眼参数的变化。
目的探讨血液透析患者眼部各项参数的变化。前瞻性观察性研究。该研究纳入了来自113例慢性肾脏疾病和急性肾损伤患者的113只眼睛,这些患者在2021年1月至2022年8月期间接受了血液透析。所有参与者均进行了完整的眼科检查,包括最佳矫正视力(BCVA)、裂隙灯检查、眼内压(IOP)测量以及裂隙灯生物显微镜和间接检眼镜的扩张检查。所有患者在接受血液透析前进行光学相干断层扫描(OCT),并评估中央亚场厚度(CST)、视网膜神经纤维层(RNFL)和神经节细胞复体(GCC)厚度。血液透析后1 ~ 2小时内复查眼科检查和OCT扫描。结果研究人群平均年龄(±SD)为42.14±13.25岁,男性占65.5%。大多数参与者的年龄在41-60岁之间。血液透析后BCVA和IOP无明显变化(p = 0.74和p = 0.37)。视网膜参数有明显改变,CST降低(p p = 0.04)。RNFL厚度无显著变化(p = 0.44)。CST与透析液流速正相关,与血流量负相关。超滤膜厚度与透析液流速之间存在微弱的相关性。结论血液透析导致视网膜参数改变,CST和GCC厚度降低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
372
审稿时长
3-8 weeks
期刊介绍: The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.
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