Frosted branch angiitis post COVID vaccine: A presumptive association with Behçet's disease.

IF 1.4 4区医学 Q3 OPHTHALMOLOGY

European Journal of Ophthalmology Pub Date : 2025-02-19 DOI:10.1177/11206721251321537

Victor Alegre-Ituarte, Bahram Bodaghi, Sara Touhami

{"title":"Frosted branch angiitis post COVID vaccine: A presumptive association with Behçet's disease.","authors":"Victor Alegre-Ituarte, Bahram Bodaghi, Sara Touhami","doi":"10.1177/11206721251321537","DOIUrl":null,"url":null,"abstract":"Purpose: To report a case highlighting the uncommon presentation of Frosted Branch Angiitis (FBA) in Behçet's Disease (BD), notably in a patient who received a COVID vaccine one month prior to the onset of symptoms. We explore the possible role of vaccination in unmasking BD.Methods: A comprehensive evaluation of a 45-year-old patient with FBA post-COVID vaccination was undertaken.Results: The patient exhibited characteristic features of FBA, with classic perivascular sheathing, optic disc edema, and retinal ischemia, which manifested one month after receiving the Pfizer/BioNTech COVID vaccine. Despite a history of recurrent oral aphthosis, systemic workup for autoimmune conditions was unremarkable. Diagnosis of presumptive Behçet's Disease was made based on clinical criteria. Treatment with intravenous methylprednisolone and infliximabn (5 mg/kg) led to complete resolution of ocular symptoms and retinal signs.Conclusion: FBA is an uncommon presentation of BD. This case also serves as a stark reminder of the potential consequences of vaccination on immune-mediated diseases. However, the correlation between FBA onset, COVID vaccination, and Behçet's Disease diagnosis necessitates cautious interpretation. Successful use of methylprednisolone and infliximab in achieving resolution of visual symptoms highlights potential therapeutic considerations in similar cases.","PeriodicalId":12000,"journal":{"name":"European Journal of Ophthalmology","volume":" ","pages":"11206721251321537"},"PeriodicalIF":1.4000,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/11206721251321537","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: To report a case highlighting the uncommon presentation of Frosted Branch Angiitis (FBA) in Behçet's Disease (BD), notably in a patient who received a COVID vaccine one month prior to the onset of symptoms. We explore the possible role of vaccination in unmasking BD.

Methods: A comprehensive evaluation of a 45-year-old patient with FBA post-COVID vaccination was undertaken.

Results: The patient exhibited characteristic features of FBA, with classic perivascular sheathing, optic disc edema, and retinal ischemia, which manifested one month after receiving the Pfizer/BioNTech COVID vaccine. Despite a history of recurrent oral aphthosis, systemic workup for autoimmune conditions was unremarkable. Diagnosis of presumptive Behçet's Disease was made based on clinical criteria. Treatment with intravenous methylprednisolone and infliximabn (5 mg/kg) led to complete resolution of ocular symptoms and retinal signs.

Conclusion: FBA is an uncommon presentation of BD. This case also serves as a stark reminder of the potential consequences of vaccination on immune-mediated diseases. However, the correlation between FBA onset, COVID vaccination, and Behçet's Disease diagnosis necessitates cautious interpretation. Successful use of methylprednisolone and infliximab in achieving resolution of visual symptoms highlights potential therapeutic considerations in similar cases.

查看原文本刊更多论文

冠状病毒疫苗后的霜状支血管炎：与behaperet病的推定关联

目的：报告一例behet病（BD）中罕见的霜状支血管炎（FBA），特别是在症状出现前一个月接种了COVID疫苗的患者。方法：对1例45岁的FBA患者进行综合评价。结果：患者在接受辉瑞/BioNTech COVID疫苗1个月后表现出典型的血管周围鞘、视盘水肿和视网膜缺血的FBA特征。尽管有复发性口腔溃疡的病史，但自身免疫性疾病的系统检查并不显著。推定behaperet病的诊断依据临床标准。静脉注射甲基强的松龙和英夫利昔单抗（5mg /kg）治疗导致眼部症状和视网膜体征完全消退。结论：FBA是一种罕见的双相障碍的表现。该病例也清楚地提醒人们接种疫苗对免疫介导性疾病的潜在后果。然而，FBA发病、COVID疫苗接种和behaperet病诊断之间的相关性需要谨慎解释。成功使用甲基强的松龙和英夫利昔单抗在实现视觉症状的解决突出潜在的治疗考虑在类似的情况下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Ophthalmology 医学-眼科学

CiteScore

3.60

自引率

0.00%

发文量

372

审稿时长

3-8 weeks

期刊介绍： The European Journal of Ophthalmology was founded in 1991 and is issued in print bi-monthly. It publishes only peer-reviewed original research reporting clinical observations and laboratory investigations with clinical relevance focusing on new diagnostic and surgical techniques, instrument and therapy updates, results of clinical trials and research findings.